Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Diclofensine hydrochloride Catalog Number : T7745 CAS Number : 34041-84-4 Molecular Formula : C17H18Cl3NO Molecular Weight : 358.69

Description: Diclofensine hydrochloride is a Novel , on Peripheral Adrenergic Function

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

H2O 52 mg/mL (144.97 mM) Solubility ( < 1 mg/ml refers to the product slightly soluble or insoluble ) In vitro Activity The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, , and (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake. PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI). In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron[1].

Reference 1. S Gasić, Korn A , Eichler H G . Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function[J]. Clinical Pharmacology & Therapeutics, 1986, 39. 2. Renzo G D , Amoroso S , Taglialatela M , et al. Pure uptake blockers of can reduce prolactin secretion: Studies with diclofensine[J]. Life Sciences, 1988, 42(21):2161-2169.

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