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)&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE 99-45-6 ACEFURTIAMINE 10072-48-7 AFALANINE 2901-75-9 ACEFYLLINE CLOFIBROL 70788-27-1 AFELIMOMAB 156227-98-4 ACEFYLLINE PIPERAZINE 18428-63-2 AFLOQUALONE 56287-74-2 ACEGLATONE 642-83-1 AFOVIRSEN 151356-08-0 ACEGLUTAMIDE 2490-97-3 AFUROLOL 65776-67-2 ACEMANNAN 110042-95-0 AGANODINE 86696-87-9 ACEMETACIN 53164-05-9 AGLEPRISTONE 124478-60-0 ACENEURAMIC ACID 131-48-6 AKLOMIDE 3011-89-0 ACENOCOUMAROL 152-72-7 ALACEPRIL 74258-86-9 ACEPERONE 807-31-8 ALAFOSFALIN 60668-24-8 ACEPROMAZINE 61-00-7 ALANINE 56-41-7 ACEPROMETAZINE 13461-01-3 ALANOSINE 5854-93-3 ACEQUINOLINE 42465-20-3 ALAPROCLATE 60719-82-6 ACESULFAME 33665-90-6 ALAZANINE TRICLOFENATE 5779-59-9 ACETAMINOSALOL 118-57-0 ALBENDAZOLE 54965-21-8 ACETARSOL 97-44-9 ALBENDAZOLE OXIDE 54029-12-8 ACETAZOLAMIDE 59-66-5 ALBIFYLLINE 107767-55-5 ACETERGAMINE 3031-48-9 ALBUTOIN 830-89-7 ACETIAMINE 299-89-8 ALCLOFENAC 22131-79-9 ACETIROMATE 2260-08-4 ALCLOMETASONE 67452-97-5 ACETOHEXAMIDE 968-81-0 ALCLOXA 1317-25-5 ACETOHYDROXAMIC ACID 546-88-3 ALCURONIUM CHLORIDE 15180-03-7 ACETOPHENAZINE 2751-68-0 ALDESULFONE SODIUM 144-75-2 ACETORPHINE 25333-77-1 ALDIOXA 5579-81-7 ACETRYPTINE 3551-18-6 ALDOSTERONE 52-39-1 ACETYLCHOLINE CHLORIDE 60-31-1 ALENDRONIC ACID 66376-36-1 ACETYLCYSTEINE 616-91-1 ALENTEMOL 112891-97-1 ACETYLDIGITOXIN 1111-39-3 ALEPRIDE 66564-15-6 ACETYLLEUCINE 99-15-0 ALESTRAMUSTINE 139402-18-9 ACETYLMETHADOL 509-74-0 ALEXIDINE 22573-93-9 ACEVALTRATE 25161-41-5 ALEXITOL SODIUM 66813-51-2 ACEXAMIC ACID 57-08-9 ALFACALCIDOL 41294-56-8 ACICLOVIR 59277-89-3 ALFADEX 10016-20-3 ACIFRAN 72420-38-3 ALFADOLONE 14107-37-0 ACIPIMOX 51037-30-0 ALFAPROSTOL 74176-31-1 ACITAZANOLAST 114607-46-4 ALFAXALONE 23930-19-0 ACITEMATE 101197-99-3 ALFENTANIL 71195-58-9 ACITRETIN 55079-83-9 ALFETAMINE 4255-23-6 ACIVICIN 42228-92-2 ALFUZOSIN 81403-80-7 ACLANTATE 39633-62-0 ALGELDRATE 1330-44-5 ACLARUBICIN 57576-44-0 ALGESTONE 595-77-7 ACLATONIUM NAPADISILATE 55077-30-0 ALGLUCERASE 143003-46-7 ACODAZOLE 79152-85-5 ALIBENDOL 26750-81-2 ACONIAZIDE 13410-86-1 ALICONAZOLE 63824-12-4 ACOXATRINE 748-44-7 ALIFEDRINE 78756-61-3 ACRIDOREX 47487-22-9 ALIFLURANE 56689-41-9 ACRIFLAVINIUM CHLORIDE 8063-24-9 ALIMADOL 52742-40-2 ACRIHELLIN 67696-82-6 ALIMEMAZINE 84-96-8 ACRISORCIN 7527-91-5 ALINIDINE 33178-86-8 ACRIVASTINE 87848-99-5 ALIPAMIDE 3184-59-6 ACROCINONIDE 28971-58-6 ALIZAPRIDE 59338-93-1 ACRONINE 7008-42-6 ALLETORPHINE 23758-80-7 ACTAGARDIN ALLOBARBITAL 52-43-7 ACTAPLANIN 37305-75-2 ALLOCLAMIDE 5486-77-1 ACTARIT 18699-02-0 ALLOCUPREIDE SODIUM 5965-40-2 ACTINOQUINOL 15301-40-3 ALLOMETHADIONE 526-35-2 ACTISOMIDE 96914-39-5 ALLOPURINOL 315-30-0 )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 4 Table 1 (con.) Product CAS Number Product CAS Number ALLYLESTRENOL 432-60-0 AMFONELIC ACID 15180-02-6 ALLYLPRODINE 25384-17-2 AMICARBALIDE 3459-96-9 ALLYLTHIOUREA 109-57-9 AMICIBONE 23271-63-8 ALMADRATE SULFATE 60239-66-9 AMICYCLINE 5874-95-3 ALMAGATE 66827-12-1 AMIDANTEL 49745-00-8 ALMAGODRATE AMIDAPSONE 3569-77-5 ALMASILATE 71205-22-6 AMIDEFRINE MESILATE 1421-68-7 ALMECILLIN 87-09-2 AMIFLAMINE 77518-07-1 ALMESTRONE 10448-96-1 AMIFLOVERINE 54063-24-0 ALMINOPROFEN 39718-89-3 AMIFLOXACIN 86393-37-5 ALMITRINE 27469-53-0 AMIFOSTINE 20537-88-6 ALMOKALANT 123955-10-2 AMIKACIN 37517-28-5 ALMOXATONE 84145-89-1 AMIKHELLINE 4439-67-2 ALNESPIRONE 138298-79-0 AMILORIDE 2609-46-3 ALNIDITAN 152317-89-0 AMINDOCATE 31386-24-0 ALONACIC 105292-70-4 AMINEPTINE 57574-09-1 ALONIMID 2897-83-8 AMINITROZOLE 140-40-9 ALORACETAM 119610-26-3 AMINOACRIDINE 90-45-9 ALOSETRON 122852-42-0 AMINOCAPROIC ACID 60-32-2 ALOVUDINE 25526-93-6 AMINOETHYL NITRATE 646-02-6 ALOXIPRIN 9014-67-9 AMINOGLUTETHIMIDE 125-84-8 ALOXISTATIN 88321-09-9 AMINOMETRADINE 642-44-4 ALOZAFONE 65899-72-1 AMINOPHENAZONE 58-15-1 ALPERTINE 27076-46-6 AMINOPHENAZONE CYCLAMATE 747-30-8 ALPHACETYLMETHADOL 17199-58-5 AMINOPHYLLINE 317-34-0 ALPHAMEPRODINE 468-51-9 AMINOPROMAZINE 58-37-7 ALPHAMETHADOL 17199-54-1 AMINOPTERIN SODIUM 58602-66-7 ALPHAPRODINE 77-20-3 AMINOQUINOL 10023-54-8 ALPIDEM 82626-01-5 AMINOQUINURIDE 3811-56-1 ALPIROPRIDE 81982-32-3 AMINOREX 2207-50-3 ALPRAFENONE 124316-02-5 AMINOTHIAZOLE 96-50-4 ALPRAZOLAM 28981-97-7 AMINOXYTRIPHENE 5585-64-8 ALPRENOLOL 13655-52-2 AMIODARONE 1951-25-3 ALPROSTADIL 745-65-3 AMIPERONE 1580-71-8 ALRESTATIN 51411-04-2 AMIPHENAZOLE 490-55-1 ALSACTIDE 34765-96-3 AMIPIZONE 69635-63-8 ALTANSERIN 76330-71-7 AMIPRILOSE 56824-20-5 ALTAPIZONE 93277-96-4 AMIQUINSIN 13425-92-8 ALTECONAZOLE 93479-96-0 AMISOMETRADINE 550-28-7 ALTEPLASE 105857-23-6 AMISULPRIDE 71675-85-9 ALTIZIDE 5588-16-9 AMITEROL 54063-25-1 ALTOQUALINE 121029-11-6 AMITIVIR 111393-84-1 ALTRENOGEST 850-52-2 AMITRAZ 33089-61-1 ALTRETAMINE 645-05-6 AMITRIPTYLINE 50-48-6 ALTUMOMAB 156586-92-4 AMITRIPTYLINOXIDE 4317-14-0 ALUMINIUM CLOFIBRATE 24818-79-9 AMIXETRINE 24622-72-8 ALUSULF 61115-28-4 AMLEXANOX 68302-57-8 ALVERINE 150-59-4 AMLODIPINE 88150-42-9 ALVIRCEPT SUDOTOX 137487-62-8 AMOBARBITAL 57-43-2 AMADINONE 30781-27-2 AMOCARZINE 36590-19-9 AMAFOLONE 50588-47-1 AMODIAQUINE 86-42-0 AMANOZINE 537-17-7 AMOGASTRIN 16870-37-4 AMANTADINE 768-94-5 AMOLANONE 76-65-3 AMANTANIUM BROMIDE 58158-77-3 AMONAFIDE 69408-81-7 AMANTOCILLIN 10004-67-8 AMOPROXAN 22661-76-3 AMBAMUSTINE 85754-59-2 AMOPYROQUINE 550-81-2 AMBASILIDE 83991-25-7 AMOROLFINE 78613-35-1 AMBAZONE 539-21-9 AMOSCANATE 26328-53-0 AMBENONIUM CHLORIDE 115-79-7 AMOSULALOL 85320-68-9 AMBENOXAN 2455-84-7 AMOXAPINE 14028-44-5 AMBICROMIL 58805-38-2 AMOXECAINE 553-65-1 AMBOMYCIN 1402-81-9 AMOXICILLIN 26787-78-0 AMBROXOL 18683-91-5 AMOXYDRAMINE CAMSILATE 15350-99-9 AMBRUTICIN 58857-02-6 AMPEROZIDE 75558-90-6 AMBUCAINE 119-29-9 AMPHENIDONE 134-37-2 AMBUCETAMIDE 519-88-0 AMPHOTALIDE 1673-06-9 AMBUSIDE 3754-19-6 AMPHOTERICIN B 1397-89-3 AMCINAFAL 3924-70-7 AMPICILLIN 69-53-4 AMCINAFIDE 7332-27-6 AMPIROXICAM 99464-64-9 AMCINONIDE 51022-69-6 AMPROLIUM 121-25-5 AMEBUCORT 83625-35-8 AMPYRIMINE 5587-93-9 AMEDALIN 22136-26-1 AMPYZINE 5214-29-9 AMELTOLIDE 787-93-9 AMQUINATE 17230-85-2 AMESERGIDE 121588-75-8 AMRINONE 60719-84-8 AMETANTRONE 64862-96-0 AMRUBICIN 110267-81-7 AMEZEPINE 60575-32-8 AMSACRINE 51264-14-3 AMEZINIUM METILSULFATE 30578-37-1 AMTOLMETIN GUACIL 87344-06-7 AMFEBUTAMONE 34911-55-2 AMYLMETACRESOL 1300-94-3 AMFECLORAL 5581-35-1 ANAGESTONE 2740-52-5 AMFENAC 51579-82-9 ANAGRELIDE 68475-42-3 AMFEPENTOREX 15686-27-8 ANAKINRA 143090-92-0 AMFEPRAMONE 90-84-6 ANARITIDE 95896-08-5 AMFETAMINE 300-62-9 ANASTROZOLE 120511-73-1 AMFETAMINIL 17590-01-1 ANAXIRONE 77658-97-0 AMFLUTIZOLE 82114-19-0 ANAZOCINE 15378-99-1 AMFOMYCIN 1402-82-0 ANAZOLENE SODIUM 3861-73-2 )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 5 Table 1 (con.) ProductCAS Number Product CAS Number ANCAROLOL 75748-50-4 ATAPROST 83997-19-7 ANCITABINE 31698-14-3 ATENOLOL 29122-68-7 ANCROD 9046-56-4 ATEVIRDINE 136816-75-6 ANDOLAST 132640-22-3 ATEXAKIN ALFA 143631-61-2 ANDROSTANOLONE 521-18-6 ATIBEPRONE 153420-96-3 ANGIOTENSIN II 4474-91-3 ATIPAMEZOLE 104054-27-5 ANGIOTENSINAMIDE 53-73-6 ATIPROSIN 89303-63-9 ANIDOXIME 34297-34-2 ATOLIDE 16231-75-7 ANILAMATE 5591-49-1 ATORVASTATIN 134523-00-5 ANILERIDINE 144-14-9 ATOSIBAN 90779-69-4 ANILOPAM 53716-46-4 ATOVAQUONE 95233-18-4 ANIPAMIL 83200-10-6 ATRACURIUM BESILATE 64228-81-5 ANIRACETAM 72432-10-1 ATRIMUSTINE 75219-46-4 ANIROLAC 66635-85-6 ATRINOSITOL 28841-62-5 ANISACRIL 5129-14-6 ATROMEPINE 428-07-9 ANISINDIONE 117-37-3 ATROPINE METHONITRATE 52-88-0 ANISOPIROL 442-03-5 ATROPINE OXIDE 4438-22-6 ANISTREPLASE 81669-57-0 AURANOFIN 34031-32-8 ANITRAZAFEN 63119-27-7 AUROTHIOGLYCANIDE 16925-51-2 ANPIRTOLINE 98330-05-3 AVICATONIN 103451-84-9 ANSOXETINE 79130-64-6 AVILAMYCIN 11051-71-1 ANTAFENITE 15301-45-8 AVIZAFONE 65617-86-9 ANTAZOLINE 91-75-8 AVOBENZONE 70356-09-1 ANTAZONITE 25422-75-7 AVOPARCIN 37332-99-3 ANTELMYCIN 1402-84-2 AVRIDINE 35607-20-6 ANTHIOLIMINE 305-97-5 AXAMOZIDE 85076-06-8 ANTIENITE 5029-05-0 AZABON 1150-20-5 ANTITHROMBIN III, HUMAN 9000-94-6 AZABUPERONE 2856-81-7 ANTRAFENINE 55300-29-3 AZACITIDINE 320-67-2 ANTRAMYCIN 4803-27-4 AZACLORZINE 49864-70-2 APAFANT 105219-56-5 AZACONAZOLE
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    NARMS – EB 2000 Veterinary Isolates Fig. 18. Resistance Among Salmonella Serotypes for Isolates from Cattle* S. typhimurium (n=332)** S. montevideo (n=330) Amikacin 0.00% Amikacin 0.00% Amox-Clav 14.46% Amox-Clav 0.61% Ampicillin 66.87% Ampicillin 0.61% Apramycin 1.20% Apramycin 0.00% Cefoxitin 10.54% Cefoxitin 0.61% Ceftiofur 12.65% Ceftiofur 0.61% Ceftriaxone 0.00% Ceftriaxone 0.00% Cephalothin 13.25% Cephalothin 0.61% Chloramphenicol 39.46% Chloramphenicol 0.91% Ciprofloxacin 0.00% Ciprofloxacin 0.00% Gentamicin 3.31% Gentamicin 0.30% Kanamycin 38.86% Kanamycin 0.00% Nalidixic Acid 0.00% Nalidixic Acid 0.00% Streptomycin 66.57% Streptomycin 1.52% Sulfamethoxazole 66.87% Sulfamethoxazole 1.21% Tetracycline 66.57% Tetracycline 2.12% Trimeth-Sulfa 5.42% Trimeth-Sulfa 0.30% 0% 10% 20% 30% 40% 50% 60% 70% 80% 0% 1% 1% 2% 2% 3% **including copenhagen S. anatum (n=292) S. newport (n=185) Amikacin 0.00% Amikacin 0.00% Amox-Clav 1.71% Amox-Clav 80.00% Ampicillin 2.40% Ampicillin 80.54% Apramycin 0.00% Apramycin 0.00% Cefoxitin 1.37% Cefoxitin 77.84% Ceftiofur 1.37% Ceftiofur 80.00% Ceftriaxone 0.00% Ceftriaxone 2.16% Cephalothin 2.05% Cephalothin 77.84% Chloramphenicol 1.71% Chloramphenicol 81.62% Ciprofloxacin 0.00% Ciprofloxacin 0.00% Gentamicin 0.68% Gentamicin 7.57% Kanamycin 1.71% Kanamycin 7.57% Nalidixic Acid 0.34% Nalidixic Acid 0.00% Streptomycin 2.05% Streptomycin 82.70% Sulfamethoxazole 2.05% Sulfamethoxazole 74.05% Tetracycline 35.96% Tetracycline 83.24% Trimeth-Sulfa 0.34% Trimeth-Sulfa 25.41% 0% 5% 10% 15% 20% 25% 30% 35% 40% 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% *all sources NARMS – EB 2000 Veterinary Isolates Fig.
  • The In¯Uence of Medication on Erectile Function

    The In¯Uence of Medication on Erectile Function

    International Journal of Impotence Research (1997) 9, 17±26 ß 1997 Stockton Press All rights reserved 0955-9930/97 $12.00 The in¯uence of medication on erectile function W Meinhardt1, RF Kropman2, P Vermeij3, AAB Lycklama aÁ Nijeholt4 and J Zwartendijk4 1Department of Urology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands; 2Department of Urology, Leyenburg Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands; 3Pharmacy; and 4Department of Urology, Leiden University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands Keywords: impotence; side-effect; antipsychotic; antihypertensive; physiology; erectile function Introduction stopped their antihypertensive treatment over a ®ve year period, because of side-effects on sexual function.5 In the drug registration procedures sexual Several physiological mechanisms are involved in function is not a major issue. This means that erectile function. A negative in¯uence of prescrip- knowledge of the problem is mainly dependent on tion-drugs on these mechanisms will not always case reports and the lists from side effect registries.6±8 come to the attention of the clinician, whereas a Another way of looking at the problem is drug causing priapism will rarely escape the atten- combining available data on mechanisms of action tion. of drugs with the knowledge of the physiological When erectile function is in¯uenced in a negative mechanisms involved in erectile function. The way compensation may occur. For example, age- advantage of this approach is that remedies may related penile sensory disorders may be compen- evolve from it. sated for by extra stimulation.1 Diminished in¯ux of In this paper we will discuss the subject in the blood will lead to a slower onset of the erection, but following order: may be accepted.
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE

    )&F1y3x PHARMACEUTICAL APPENDIX to THE

    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
  • Genl:VE 1970 © World Health Organization 1970

    Genl:VE 1970 © World Health Organization 1970

    Nathan B. Eddy, Hans Friebel, Klaus-Jiirgen Hahn & Hans Halbach WORLD HEALTH ORGANIZATION ORGANISATION .MONDIALE DE LA SANT~ GENl:VE 1970 © World Health Organization 1970 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. Nevertheless governmental agencies or learned and professional societies may reproduce data or excerpts or illustrations from them without requesting an authorization from the World Health Organization. For rights of reproduction or translation of WHO publications in toto, application should be made to the Division of Editorial and Reference Services, World Health Organization, Geneva, Switzerland. The World Health Organization welcomes such applications. Authors alone are responsible for views expressed in signed articles. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Director-General of the World Health Organization concerning the legal status of any country or territory or of its authorities, or concerning the delimitation of its frontiers. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. © Organisation mondiale de la Sante 1970 Les publications de l'Organisation mondiale de la Sante beneficient de la protection prevue par les dispositions du Protocole n° 2 de la Convention universelle pour la Protection du Droit d'Auteur. Les institutions gouvernementales et les societes savantes ou professionnelles peuvent, toutefois, reproduire des donnees, des extraits ou des illustrations provenant de ces publications, sans en demander l'autorisation a l'Organisation mondiale de la Sante. Pour toute reproduction ou traduction integrate, une autorisation doit etre demandee a la Division des Services d'Edition et de Documentation, Organisation mondiale de la Sante, Geneve, Suisse.
  • Appendix 13C: Clinical Evidence Study Characteristics Tables

    Appendix 13C: Clinical Evidence Study Characteristics Tables

    APPENDIX 13C: CLINICAL EVIDENCE STUDY CHARACTERISTICS TABLES: PHARMACOLOGICAL INTERVENTIONS Abbreviations ............................................................................................................ 3 APPENDIX 13C (I): INCLUDED STUDIES FOR INITIAL TREATMENT WITH ANTIPSYCHOTIC MEDICATION .................................. 4 ARANGO2009 .................................................................................................................................. 4 BERGER2008 .................................................................................................................................... 6 LIEBERMAN2003 ............................................................................................................................ 8 MCEVOY2007 ................................................................................................................................ 10 ROBINSON2006 ............................................................................................................................. 12 SCHOOLER2005 ............................................................................................................................ 14 SIKICH2008 .................................................................................................................................... 16 SWADI2010..................................................................................................................................... 19 VANBRUGGEN2003 ....................................................................................................................
  • A Sensitive Method for Direct Analysis of Impurities in Apramycin and Other Aminoglycoside Antibiotics Using Charged Aerosol

    A Sensitive Method for Direct Analysis of Impurities in Apramycin and Other Aminoglycoside Antibiotics Using Charged Aerosol

    - SO4 A Sensitive Method for Direct Analysis of Impurities in Apramycin and Other Aminoglycoside Antibiotics Using Charged Aerosol Detection Zhen Long1, Qi Zhang2, Yan Jin1, Lina Liang1, Bruce Bailey2, Ian Acworth2, Deepali Mohindra3 1 2 3 Thermo Fisher Scientific, Shanghai, China, Thermo Fisher Scientific, Chelmsford, MA, USA and Thermo Fisher Scientific, Sunnyvale, CA, USA Comparison of CAD and ELSD Detection Analysis of Other Aminoglycoside Antibiotics Overview Results Purpose: To develop a sensitive non-derivatization method for impurity assessment of Sample pre-treatment with SPE This method has also been applied to impurity analysis of an additional eleven apramycin sulfate and other aminoglycoside antibiotics. Sample pre-treatment with SPE SPE Column: Dionex OnGuard II A CAD and ELSD are both nebulization-based universal detection technologies. aminoglycoside antibiotics, including neomycin, gentamicin, kanamycin, streptomycin, Comparison between CAD and ELSD under the same chromatographic conditions tobramycin, amikacin, etimicin, netilmicin, sisomicin, ribostamycin and paromomycin. Methods: A 30min gradient method using hydrophilic interaction liquid chromatography Sample solvent: 80% 5mM ammonium formate, 20% acetonitrile Sulfate is a major interference for apramycin impurity assessment with a HILIC method. demonstrated that CAD is much more sensitive than ELSD. As shown in the Figure 5 shows impurity analysis of kenamycin, etimicin, ribostamycin and paromomycin with charged aerosol detection (HILIC-CAD) was developed for direct analysis of Sample: 220.6 mg/mL in 2 mL sample solvent Without sample cleanup, some early eluting impurities were found to be masked under chromatograms in Figure 4 and data summarized in Table 1, 16 impurities (S/N >3) were using the HILIC-CAD method.