Virtually Anywhere NE 20 7 JU 21 5-2 2 / E N U J 3 1 - 2 1

PROGRAM AT A GLANCE

** All times listed in EDT (US & Canada) Start time: 6.00 PDT | 8.00 CDT | 9.00 EDT | 14.00 BST | 15.00 CEST | 21.00 CST | 23.00 AEST SATURDAY 12 JUNE 2021 CHARCOT-MARIE-TOOTH & 9.00-15.30 Education Course RELATED NEUROPATHIES CONSORTIUM (CMTR) Welcome 9.00 Welcome Address 10.00  Pieter van Doorn, MD, PhD, PNS President Michael Shy, MD, CMTR Chair Molecular Targets and Biomarkers in 9.10 Peripheral Pain Processing 10.05 Inherited Peripheral Neuropathies Stephen McMahon, PhD Rita Horvath, MD, PhD 9.50  in Complex Genetic Regulation of Axon Stability by Diseases: Approach to Diagnosis 10.35 Metabolic Coupling to Schwann Cells Alex Rossor, PhD, MBBS, MRCP Bogdan Biercowski, MD, PhD 10.30 The Node of Ranvier: The Identification and Clinical Spectrum of Latest and Breaking News 11.05 RFC1 and Other Expansions Associated with Jérôme Devaux, PhD Inherited Neuropathies 11.10 Established and Emerging Outcome Henry Houlden, MD, PhD Measures for Hereditary Neuropathy Familial Amyloid Polyneuropathy Michael Shy, MD 11.35  Márcia Waddington-Cruz, MD, PhD 12.00-13.00 Career Development Lunch 12.05 Closing Remarks PRE-REGISTRATION REQUIRED Michael Shy, MD, CMTR Chair 12.00-13.00 Break 13.10 Mechanisms in : INTERNATIONAL An Update NEUROPATHY CONSORTIUM (IDNC) Eva Feldman, MD 10.00 Welcome 13.50 Infections and the Peripheral James Russell, MD, IDNC Chair 10.05 Using RNA Sequencing on Human Peripheral James Sejvar, MD to Understand Mechanisms Driving 14.30 Clinical Case Presentations Painful Neuropathies Theodore Price, PhD SUNDAY 13 JUNE 2021 10.50 Sodium Channelopathies in Painful 9.00-9.30 Coffee Chat NETWORKING EVENT Small Fiber and in Painful Diabetic Peripheral Neuropathy 9.30-10.00 PNS Kick-Off Event Catharina Faber, MD, PhD 10.00-15.00 Special Interest Group (SIG) 11.35 Oral Poster Presentations Concurrent Sessions 12.05 Closing Remarks James Russell, MD, IDNC Chair (continued) 10 Virtually Anywhere NE 20 PROGRAM AT A GLANCE7 JU 21 5-2 2 SUNDAY 13 JUNE / 2021 (cont.) FRIDAY 25 JUNE 2021 TOXIC NEUROPATHIES CONSORTIUME (TNC) 9.00-9.30 Coffee Chat NETWORKING EVENT N 10.00 WelcomeU 9.30-10.00 Peter J Dyck Lecture Guido Cavaletti,J MD, TNC Chair Mechanisms of Cutaneous Pain Sensation Michael Caterina, MD, PhD 10.05 Metabolomics:3 A Tool for Neurological1 Research 10.00 -11.30 Platform Session I Debra- J. Skene, PhD 2 11.30 -12.00 Break 10.35 Chemotherapy-Induced1 Peripheral 12.00-12.30 Richard Bunge Lecture Neuropathy (CIPN): Characteristics, Signals to Schwann Cells During Myelination Patterns and Outcomes Across the Lifespan and Peripheral Neuropathies Ellen Lavoie Smith, PhD, MSN, RN, Laura Feltri, MD AOCN(R), FAAN 12.30-13.00 Oral Poster Session I 11.05 Debate – Different Perceptions of CIPN Ahmet Hoke, MD, PhD 13.00-14.00 Guided Poster Hall Tours Karin Jordan, MD SATURDAY 26 JUNE 2021 12.05 Closing Remarks Guido Cavaletti, MD, TNC Chair 9.00-9.30 Coffee Chat NETWORKING EVENT 12.15-12.45 Break 9.30-10.00 Arthur K Asbury Lecture Antisense Therapies for INFLAMMATORY NEUROPATHY CONSORTIUM (INC) Neurological Diseases Frank Bennett, PhD 12.45 Welcome Peter Van den Bergh, MD, PhD, FEAN, FAAN, 10.00 -11.30 Platform Session II INC Chair 11.30 -12.00 PNS Annual General Meeting 12.50 Update on Neuralgic Amyotrophy (all are welcome) Nens van Alfen, MD, PhD 12.00-12.30 Jack Griffin Lecture 13.20 The Role of Fc Receptors in Inflammatory The Molecular Mechanism of Axon Neuropathy: Emerging Targets for Degeneration: SARM1 as a Druggable Novel Therapies Target for the Prevention of Kazim Sheikh, MD Peripheral Neuropathy Aaron Diantonio, MD, PhD 13.50 Pathology of Early Guillain-Barré Syndrome Jose Berciano, PhD 12.30-13.00 Oral Poster Session II 14.20 Beyond Immunoglobulin and Steroids 13.00-14.00 Guided Poster Hall Tours in CIDP: What Can We Learn from Other Diseases? SUNDAY 27 JUNE 2021 Stephen W. Reddel, PhD 9.00-9.30 Coffee Chat NETWORKING EVENT 14.50 Closing Remarks 9.30-10.00 PK Thomas Lecture Peter Van den Bergh, MD, PhD, FEAN, FAAN, Genetics of Hereditary Spastic Paraplegia — INC Chair Overlap Between Central and Peripheral Axonopathies NEUROPATHIC PAIN CONSORTIUM (NPC) Rebecca Schüle, MD 12.45 Welcome 10.00 -11.30 Platform Session III Daniela Menichella, MD, PhD, NPC Chair 11.30 -12.00 Break 12.50 Human iPSC-derived Sensory Neurons to 12.00-12.30 Pembroke Lecture Study Painful Peripheral Neuropathy Primary Mitochondrial Neuropathies Angelika Lampert, MD Michio Hirano, MD 13.35 Neuropathic Pain Development in the Aged 12.30-14.00 Richard A.C. Hughes Session Michael Burton, PhD Clinical Science Highlights 14.20 Oral Poster Presentations 14.30-15.00 Awards Ceremony 14.50 Closing Remarks Daniela Menichella, MD, PhD, NPC Chair

2021 PNS Annual Meeting 12-13 June / 25-27 June 11