STEM CELL THERAPY Eva Feldman Russell N. Dejong Professor of Neurology, University of Michigan, USA

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STEM CELL THERAPY Eva Feldman Russell N. Dejong Professor of Neurology, University of Michigan, USA

BEST FUTURE STRATEGIES FOR NEUROREHABILITATION - STEM CELL THERAPY Eva Feldman Russell N. DeJong Professor of Neurology, University of Michigan, USA Neurodegenerative diseases are increasing at an alarming rate as the worldwide population ages. There are few effective treatments for these disorders that include Alzheimer’s disease (AD), Parkinson’s and Huntington’s disease, and amyotrophic lateral sclerosis (ALS). Cellular therapies offer a unique opportunity to delay or even improve the clinical course of these disorders. Treatment objectives typically center on cellular replacement or providing environmental enrichment. The two most common approaches involve the transplantation of fetal tissue grafts or of stem cells, the focus of today’s debate. Stem cells have the capacity to proliferate and differentiate into multiple cellular lineages. There are different classifications of stem cells that reflect the range of possible cell types they can produce, and include embryonic stem (ES) cells, progenitor cells, mesenchymal stem cells (MSCs), and induced pluripotent stem (iPS) cells. Stem cells may provide cellular replacement, or more commonly provide environmental enrichment to support host neurons by producing neurotrophic factors, scavenging toxic factors or creating auxiliary neural networks around affected areas and improving neural circuitry. Many strategies for environmental enrichment utilize stem cells to provide de novo synthesis and delivery of neuroprotective growth factors at the site of disease. Neural progenitor stem cells are currently being transplanted into the spinal cords of patients with ALS and multiple transplants alter the normal relentless progression of the disease. While more research is required, including highly controlled clinical trials, recent success with cellular therapy in ALS provides the beginning of a new therapeutic era in neurodegenerative disorders. .

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A 2020 Centenary Perspective on Neuromuscular Disorders Stephen a Goutman ‍ ‍ , Brian Christopher Callaghan ‍ ‍ , Eva Feldman ‍ ‍
2020 Vision J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp-2020-324327 on 14 July 2020. Downloaded from A MODERN 2020 CENTENARY PERSPECTIVE ON TRAIL BLAZING PAPERS FROM THE JNNP ARCHIVE A 2020 centenary perspective on neuromuscular disorders Stephen A Goutman , Brian Christopher Callaghan , Eva Feldman last 100 years is remarkable. When JNNP able to create the groupings of patients first began publishing articles the struc- needed to begin deciphering the under- ture of DNA was unknown, and today we lying genetic causes of disease. These have effective gene-targeted therapies that groupings were in place as technology alter the course of multiple neuromuscular moved from linkage analysis to Sanger diseases. One year ago, we were chal- sequencing to next generation sequencing, lenged to consider the ‘most important or creating the clinical framework to detect transformative development in neurology’ the underlying defects in the genetic code. in the past 100 years and how JNNP contributed to this achievement given its GENE-BASED THERAPEUTIC TARGETS 3 broad scope. To our surprise, no nomi- At this writing, the GeneTable of nation for neuromuscular disorders made Neuromuscular Disorders (http://www. 4 the final list. Therefore, we wish to put musclegenetable.fr/ index. html) lists 587 forth a nomination for neuromuscular genes associated with 1042 disorders. disorders. All articles cited for this nomi- These include 97 entries for heredi- nation are published in JNNP. We contend Genetic diagnoses and gene-based tary motor
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Practiceupdateadc2018
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Feldman, Eva (2009)
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