FBXO5 Antibody Cat. No.: 58-707

FBXO5 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This FBXO5 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 192-221 amino acids from the Central region of human FBXO5.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 50 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

September 27, 2021 1 https://www.prosci-inc.com/fbxo5-antibody-58-707.html BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: FBXO5

ALTERNATE NAMES: F-box only protein 5, Early mitotic inhibitor 1, FBXO5, EMI1, FBX5

ACCESSION NO.: Q9UKT4

PROTEIN GI NO.: 24636847

GENE ID: 26271

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

This encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box constitute one of the four subunits of the protein ligase complex called SCFs (SKP1--F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich BACKGROUND: repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.

REFERENCES: 1) Lei, S.F., et al. J. Bone Miner. Res. (2010) In press :

2) Ma, H.T., et al. Mol. Cell. Biol. 29(24):6500-6514(2009)

3) Lee, J., et al. Mol. Biol. Cell 20(7):1891-1902(2009)

4) Gutgemann, I., et al. Mod. Pathol. 21(4):445-454(2008)

ANTIBODIES FOR RESEARCH USE ONLY.

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