FBXO5 Antibody Cat. No.: 58-707
FBXO5 Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human
This FBXO5 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 192-221 amino acids from the Central region of human FBXO5.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR 50 kDa WEIGHT:
Properties
This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
PHYSICAL STATE: Liquid
September 27, 2021 1 https://www.prosci-inc.com/fbxo5-antibody-58-707.html BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: FBXO5
ALTERNATE NAMES: F-box only protein 5, Early mitotic inhibitor 1, FBXO5, EMI1, FBX5
ACCESSION NO.: Q9UKT4
PROTEIN GI NO.: 24636847
GENE ID: 26271
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich BACKGROUND: repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.
REFERENCES: 1) Lei, S.F., et al. J. Bone Miner. Res. (2010) In press :
2) Ma, H.T., et al. Mol. Cell. Biol. 29(24):6500-6514(2009)
3) Lee, J., et al. Mol. Biol. Cell 20(7):1891-1902(2009)
4) Gutgemann, I., et al. Mod. Pathol. 21(4):445-454(2008)
ANTIBODIES FOR RESEARCH USE ONLY.
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