Nucleic Acids Research

Executive editors

R.T.Walker, Birmingham, UK M.J.Gait, Cambridge, UK R.B.Hallick, Tucson, AZ, USA R.J.Roberts, Beverly, MA, USA H.J.Gross, Wulrzburg, Germany S.Linn, Berkeley, CA, USA K.Calame, New York, NY, USA R.I.Gumport, Urbana, IL, USA R.T.Simpson, University Park, PA, USA I.C.Eperon, Leicester, UK Editorial board

A.Bairoch, Geneva, Switzerland J.E.Hearst, Berkeley, CA, USA M.G.Parker, London, UK M.Beato, Marburg, Germany C.Helene, Paris, France R.K.Patient, London, UK M.Belfort, Albany, NY, USA A.J.Jeffreys, Leicester, UK M.Paule, Fort Collins, CO, USA M.Busslinger, Vienna, Austria S.-H.Kim, Berkeley, CA, USA A.M.Pyle, New York, NY, USA H.Cedar, Jerusalem, Israel A.R.Krainer, CSHL, NY, USA J.M.Rosen, Houston, TX, USA R.Dalgleish, Leicester, UK R.Krumlauf, London, UK H.Ruterjans, Frankfurt, Germany M.L.DePamphilis, Nutley, NJ, USA A.Lamond, Dundee, UK C.W.Schmid, Davis, CA, USA W.Dynan, Boulder, CO, USA D.S.Latchman, London, UK P.M.Sharp, Nottingham, UK F.Eckstein, Gdttingen, Germany C.J.Leaver, Oxford, UK L.Simpson, Los Angeles, CA, USA J.D.Engel, Evanston, IL, USA D.M.J.Lilley, Dundee, UK S.T.Smale, Los Angeles, CA, USA P.T.Englund, Baltimore, MD, USA J.T.Lis, Ithaca, NY, USA G.Stormo, Boulder, CO, USA D.J.Finnegan, Edinburgh, UK R.Luhrman, Marburg, Germany R.H.Symons, Adelaide, Australia M.Gellert, Bethesda, MD, USA N.C.Martin, Louisville, KY, USA K.Taira, Tsukuba, Japan R.Giege, Strasbourg, France M.McClelland, La Jolla, CA, USA I.Tinoco, Jr, Berkeley, CA, USA L.A.Grivell, Amsterdam, The Netherlands W.R.McClure, Pittsburgh, PA, USA B.Van Ness, Minneapolis, MN, USA W.Gruissem, Berkeley, CA, USA M.Muramatsu, Saitama, Japan A.M.Weiner, New Haven, CT, USA W.Guschlbauer, Gif-sur-Yvette, France E.Ohtsuka, Sapporo, Japan S.C.West, South Mimms, Herts, UK S.E.Halford, Bristol, UK H.Okayama, Tok;yo, Japan J.A.Wise, Cleveland, OH, USA D.Hawley, Eugene, OR, USA M.V.Olson, Seattle, WA, USA G.Zon, Foster City, CA, USA Editorial and Production

Joy Walker, UK Editorial Office Sarah Brennan, Production Editor Carol Cook, US Editorial Office Jaqueline Grainger, Production Assistant Robert Blundell, Production Assistant

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Nucleic Acids Research is published semi-monthly (24 issues) with an Annual K Oxford University Press 1995. All rights reserved; no part of this publication Author and Subject Index. Subscriptions are entered on a calendar year basis may be reproduced, stored in a retrieval system, or transmitted in any form only and are available as a printed version only or as a printed version plus or by any means, electronic, mechanical, photocopying, recording, or otherwise CD-ROM. Prices include postage by surface mail or, for subscribers in the without either the prior written permission of the Publishers, or a licence USA and Canada by air freight or in India, Japan, Australia and New Zealand, permitting restricted copying issued in the UK by the Copyright Licensing by Air Speeded Post. Airmail rates are available on request. Agency Ltd, 90 Tottenham Court Road, London WIP 9HE, or in the USA by the Copyright Clearance Center, 27 Congress Street, Salem, MA 01970. Annual subscription rate (Volume 23, 1995): For those in the US//Canada not registered with CCC, articles can be obtained Journal only: UK and Europe £725, Rest of World $1225. by fax in 48 hours by calling: WISE for MedicineTM 1-800-667-WISE. Journal and CD-ROM: UK and Europe £795, Rest of World $1350. Back volume prices and subscription rates for individuals are also available Back volumes of this journal are available in 16 mm microfilm, 35 mm on request. microfilm and 105 microfiche from University Microfilms International, 300 North Zeeb Road, Ann Arbor, MI 48106-1346, USA. Copies of articles Orders. Orders and payments from, or on behalf of, subscribers in the various published are also available from UMI. geographical areas shown below should be sent to the Press office indicated. Nucleic Acids Research (ISSN 0305-1048) is published semi-monthly by The Americas: Oxford University Press Inc., 2001 Evans Road, Cary, NC Oxford University Press, Oxford, UK. Annual subscription price is US$1225. 27513, USA. Nucleic Acids Research is distributed by Virgin Mailing & Distribution, 10 Camptown Road, Irvington, NJ 07111-1105, USA. Second Class postage Japan: available from the following agents: paid at Newark, NJ, USA and additional entry points. Kinokuniya Company Ltd, Journal Department, PO Box 55, Chitose, Tokyo, 156 Japan. US POSTMASTER: send address changes to Nucleic Acids Research, c/o Maruzen Company Ltd, Journal Division, PO Box 5050, Tokyo International, Virgin Mailing & Distribution, 10 Camptown Road, Irvington, NJ 07111- 100-31 Japan. 1105, USA. Usaco Corporation, 13-12, Shimbashi 1-chome, Minato-ku, Tokyo, 105 Japan. Rest of the World: Journals Subscriptions Department, Oxford University Press, Walton Street, Oxford OX2 6DP, UK. Tel: (+441865 or 01865) 267907; telex: OXPRESS 837330; Fax: (+441865) 267773. Advertising. To advertise in Nucleic Acids Research contact Oxford University Press (US office) in the Americas or Oxford University Press (UK office) in the Rest of the World (see addresses above). Printed by Information Press Ltd, Oxford, UK on permanent Paper.

Cover: The dynamic equilibrium in the control element of the S15 messenger RNA between two hairpins (top left) and a pseudoknot (bottom right). The helix in yellow is present in both structures. The pseudoknot invofves base pairing between the loop in green and the strand in red of the other hairpin. See paper by C. Philippe et al., Nucleic Acids Res. 23, 18-28. Drawing made on a Silicon Graphics EXTREME2 with the program DRAWNA [C. Massive et al., J. Mol. Graph. 12, 201 (1994)]. Authors submitting an article containing a photograph which may be suitable for use on the cover of Nucleic Acids Research are encouraged to contact an executive editor. Packed into the December issue of HMG .

ARTICLES Mutation analysis ofthe TSC2 gene in an African-American Identification ofcentromeric antigens in dicentric Robertsonian family. A Kumar, R S Kandt, C Wolpert, A D Roses, M A Pericak- translocations: CENP-C AND CENP-E are necessary components Vance and J R Gilbert P.2295 of functional centromeres B A Sullivan and S Schwartz P 2189 T->A transversion 11 bp from a splice acceptor site in the human Population survey ofthe human FMR1 CGG repeat substructure gene for steroidogenic acute regulatory protein causes congenital suggests biased polarity for the loss ofAGG lipoid adrenal hyperplasia. M-K Tee, D Lin, T Sugawara, J A Holt, interruptions. E E Eichler, H A Hammond, j N Macpherson, Y Guiguen, B Buckingham, J F Strauss III andW L Miller P.2299 P AWard and D L Nelson P 2199 RBM3, a novel human gene in Xpl 1.23 with a putative RNA- Highly conserved 3' UTR and expression pattern of FXR1 points binding domain. J M j Derry, J A Kerns and U Francke P.2307 to a divergent gene regulation of FXR1 and FMR1. J F Coy, Z Sedlacek, D Bachner, H Hameister, S joos, P Lichter, H Delius Breakpoint characterization ofthe ret/PTC oncogene in human and A Poustka P2209 papillary thyroid carcinoma. P A Smanik, T L Furminger, E L Mazzaferri and S M Jhiang P.2313 Oncogenic conversion of a novel orphan nudear receptor by chromosome translocation. Y Labelle,j Zucman, G Stenman, Analysis ofthe OA1 gene reveals mutations in only one-third of L-G Kindblom, J Knight, C Turc-Carel, B Dockhorn- patients with X-linked ocular albinism. M V Schiaffino, M T Bassi, Dworniczak, N Mandahl, C Desmuze, M Peter, A Aurias, 0 L Galli, A Renieri, M Bruttini, F De Nigris, A A B Bergen, S J Delattre and G Thomas P2219 Charles, J RWYates, A Meindl, R A Lewis, R A King and A Ballabio P.2319 REPORTS Analysis ofthe CMTIA-REP repeat: mapping crossover breakpoints Non-disjunction in human sperm: evidence for an effect of in CMTIA and HNPP. H Kiyosawa, M W Lensch and P F Chance increasing paternal age. D K Griffin, M A Abruzzo, E A Millie, P2327 L A Sheean, E Feingold, S L Sherman and T J Hassold P.2227 Characterization ofthe large deletion in the GALC gene found Stability ofthe Huntington disease (CAG)n repeat in a late- in patients with Krabbe disease. P Luzi, M A Rafi and D A Wenger onset form occurring on the Island ofCrete. M Tzagoumissakis, P.2335 C 0 Fesdjian, P Shashidharan and A Plaitakis P2239 A gene (SRPX) encoding a sushi-repeat-containing protein is Lowe Syndrome, a deficiency of a phosphatidyl-inositol 4,5- deleted in patients with X-linked retinitis pigmentosa. A Meindl, bisphophate 5-phosphatase in the Golgi apparatus. S F Suchy, M R S Carvalho, K Herrmann, B Lorenz, H Achatz, B Lorenz, I M Olivos-Glander and R L Nussbaum P2245 E Apfelstedt-Sylla, B Wittwer, M Ross and T Meitinger P2339

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation ofallelic variants ofthe human Find out more - On the Internet ! cytochrome P450 CYP2D6 gene. V M Steen, A Molven, N K Aarskog and A-K Gulbrandsen P.225 1 The above is just a partial list of the December issue contents. Ifyou have access to the internet, then you can Distinct transcription start sites generate two forms of BRCA1 join for FREE, the Human Molecular Genetics internet mRNA. C-F Xu, M A Brown, J A Chambers, B Griffiths, H mailing list and receive regular information on the entire I Nicolai and E Solomon P2259 contents ofeach issue, delivered direct to your mailbox | Mouse Brcal: sequence and identification of localization, analysis some 2 to 3 weeks before publication. I evolutionarily conserved domains. KJ Abel, Junzhe X, G-YYin, R H Lyons, M H Meisler and B L Weber P2265 Just send the message: subscribe HUM-MOLGENyour name (nar) Murine Brcal: sequence and significance for human missense to mutations. S K Sharan, M Wims and A Bradley P.2275 [email protected] and you will quickly receive confirmation ofyour Liposome-mediated gene transfer and expression via the skin. membership to the list. M Y Alexander and R J Akdurst P2279 Ifyou would like further details about HMG, including Allele-specific replication timing in imprinted domains: absence of instructions to authors or details about subscription rates, I asynchrony at several loci. H Kawame, S M Gartler and R S please contact Oxford University Press, 2001 Evans Road, Hansen P.2287 Cary, NC 27513. 1-800-852-7323; 919-677-1714 (fax) Author index

Alonso,A. 5034 Cotton,R.G.H. 5082 Koj,A. 5041 Romanienko,P.J. 5012 Ansari,P. 5027 Daniels,G.A. 5006 Kok,M. 5085 Rouet,P. 5012 Babon,J.J. 5082 Darracq,N. 5055 Kordula,T. 5041 Schaffner,W. 4978 Baron,U. 5080 Davis,D.R. 5020 Koziolkiewicz,M. 5000 Schwenk,F. 5080 Bauer-Hofmann,R. 5034 Demple,B. 5027 Krakowiak,A. 5000 Sergeant,A. 4939 Beck,J. 4954 Diaz-Orejas,R. 5048 Kwinkowski,M. 5000 Serrano-Lopez,A. 5048 Bennett,R.A.O. 5027 Doly,J. 5055 Lacoste,J. 5073 Singer,R.H. 4946 Best-Belpomme,M. 5073 Douville,P. 4978 Lahmy,S. 4963 Smih,F. 5012 Boczkowska,M. 5000 Echeverria,M. 4963 Li,Y.-P. 5064 Smith,K.F. 4992 Bonfield,J.K. 4992 Garcia de Viedma,D. 5048 Lieber,M.R. 5006 Staden,R. 4992 Bourillot,P.Y. 4939 Gary,S.L. 4986 Manet,E. 4939 Stashenko,P. 5064 Braganqa,J. 5055 Gatsios,P. 5041 Marquis,J.C. 5027 Stec,W.J. 5000 Buchwald,M. 5087 Genin,P. 5055 Nassal,M. 4954 Taneja,K.L. 4946 Bugno,M. 5041 Georgiev,O. 4978 Ohki,R. 4971 Travis,J. 5041 Burgers,P.M.J. 4986 Graeve,L. 5041 Oishi,M. 4971 Waltzer,L. 4939 Chen,M. 5087 Hagmann,M. 4978 Peronnet,F. 5073 Wilson,D.M.III 5027 Chen,W. 5064 Heinrich,P.C. 5041 Phillips,R.A. 5087 Wu,Q. 5087 Civas,A. 5055 Jasin,M. 5012 Politz,J.C. 4946 Youil,R. 5082 Codani-Simonart,S. 5073 Kiyama,R. 4971 Rajewsky,K. 5080 FORTHCOMING EVENTS

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January 5-11, 1996 January 29-February 4,1996 Keystone Symposia: Molecular and Developmental Biology ofthe Keystone Symposia: The Molecular Biology ofthe Cardiovascular Extracellular Matrix. System. Keystone, Colorado. Keystone, Colorado. January 7-12, 1996 January 29-February 4, 1996 Gordon Research Conferences: Origin ofLife. Keystone Symposia: Breast and Prostate Cancer: Basic Ventura, California. Contact: Gordon Research Center, University Mechanisms. of Rhode Island, PO Box 984, West Kingston, RI 02892-0984, Taos, New Mexico. USA. February 1-2, 1996 Fax: +1 401 783 7644 Solid Phase Synthesis. Email: [email protected] San Diego, California. Contact: Cambridge Healthtech Institute, 1037 Chestnut Street, Newton Upper Falls, MA 02164, USA. January 8-10, 1996 Fax: +1 617 630 1325 4th International Workshop ofthe Santiago Southern Symposia: Email: [email protected] Genes and Genomes: Structure, Mapping and Diversity. Santiago, Chile. Contact: Jorge E. 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Neuenheimer Feld 280, 69120 Heidelberg, Germany. Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Fax: + 49 6221 422 333 Parklawn Drive, Rockville, MD 20852, USA. Email: [email protected] Fax: +1 301 816 4364 January 23-29, 1996 Internet: http://www.atcc.org/workshops/workshop.html Keystone Symposia: Hepatitis C and Beyond. February 15-16, 1996 Burlington, Vermont. IBC Third International Conference: Oligonucleotide- and Gene Therapy-Based Antisense Therapeutics. January 28-February 2,1996 Coronado, California. Contact: IBC USA Conferences, 225 Gordon Research Conferences: Magnesium in Biochemical Turnpike Road, Southborough, MA 01772-1749, USA. Processes. Fax: +1 508 481 4473 Ventura, California. Contact: Gordon Research Center, University February 25-26, 1996 of Rhode Island, PO Box 984, West Kingston, RI 02892-0984, Gene Quantitve: Diagnostics, Monitoring and Drug Development. USA. San Diego, Califomia. 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Contact: BIODIGM Mechanisms ofExpression and Function ofMHC Class II Fax: +44 1494 446 672 Molecules. Email: [email protected] Madrid, Spain. Contact: Instituto Juan March, Castello 77, 28006 Madrid, Spain. March 4-6, 1996 Fax: +34 1 576 3420 3rd Annual Human Genome Project: Commercial Implications. San Francisco, California. Contact: Cambridge Healthtech Institute, April 1-5, 1996 1037 Chestnut Street, Newton Upper Falls, MA 02164, USA. Recombinant DNA: Techniques and Applications. Fax: +1 617 630 1325 Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Email: [email protected] Parklawn Drive, Rockville, MD 20852, USA. Fax: +1 301 816 4364 March 7-8, 1996 Internet: http://www.atcc.org/workshops/workshop.html Second Annual Genetic Screening and Diagnosis ofHuman April 9-12, 1996 Diseases. Polymerase Chain Reaction Application/Cycle DNA Sequencing. San Francisco, California. Contact: Cambridge Healthtech Institute, Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 1037 Chestnut Street, Newton Upper Falls, MA 02164, USA. Parklawn Drive, Rockville, MD 20852, USA. Fax: +1 617 630 1325 Fax: +1 301 816 4364 Email: [email protected] Internet: http://www.atcc.org/workshops/workshop.html March 10-16, 1996 April 10, 1996 Keystone Symposia: Post-transcriptional RNA Processing. International Workshop on Chromosome 2. Hilton Head Island, South Carolina. London, UK. Contact: Nigel Spurr 0 March 11-13, 19% Fax: + 44 171 269 3802 Instituto Juan March de Estudios e Investigaciones: From Email: [email protected] Transcript to Protein: mRNA Processing, Transport and April 10-23,1996 Translation. Course: Cloning and Analysis ofLarge DNA Molecules. Madrid, Spain. Contact: Instituto Juan March, Castello 77, 28006 Cold Spring Harbor, New York. Contact: Meetings and Courses Madrid, Spain. Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Fax: +34 1 576 3420 100, Cold Spring Harbor, NY 11724-2213, USA. 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Contact: Gordon Research Center, Cryopreservaton Techniques. University of Rhode Island, PO Box 984, West Kingston, RI Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 02892-0984, USA. Parklawn Drive, Rockville, MD 20852, USA. Fax: +1 401 783 7644 Fax: +1 301 8164364 Email: [email protected] Internet: http://www.atcc.org/workshops/workshop.html May 1-5, 1996 June 10-19, 1996 Meeting: Molecular Chaperones and the Heat Shock Response. FEBS Advanced Courses: Basic and Specialized Techniques in Cell Cold Spring Harbor, New York. Contact: Meetings and Courses Biology. Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Aarhus, Denmark. Contact: Prof. Dr Julio E. Celis, Institute of 100, Cold Spring Harbor, NY 11724-2213, USA. Medical Biochemistry and Danish Centre for Human Genome Fax: +1 516 367 8845 Research, University of Aarhus, Ole Worms A116 Building 170, Email: [email protected] DK-8000 Aarhus C, Denmark. 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Fax: +1 516 367 8845 Fax: +353 1 704 54 84 Email: [email protected] June 27-28, 1996 May 21-26, 1996 Institut Pasteur Euro Conferences: Emerging Viruses. Meeting: Retroviruses. Paris, France. Contact: L. Drye, Institut Pasteur Euro Conferences, Cold Spring Harbor, New York. Contact: Meetings and Courses 28 rue du Docteur Roux, 75015 Paris, France. Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Fax: +33 1 40 61 34 05 100, Cold Spring Harbor, NY 11724-2213, USA. Fax: +1 516 367 8845 June 30-July 5, 1996 Email: [email protected] Gordon Research Conferences: DNA Alteration in Transformed Cells. June 4-7, 1996 Tlhton, New Hampshire. Contact: Gordon Research Center, In Bitro Toxicology: Techniques and Applications. University of Rhode Island, PO Box 984, West Kingston, RI Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 02892-0984, USA. Parklawn Drive, Rockville, MD 20852, USA. Fax: +1 401 783 7644 Fax: +1 301 816 4364 Internet: http://www.atcc.org/workshops/workshop.html Email: [email protected] June 7-27, 1996 * July 1-3, 1996 Course: Advanced Bacterial Genetics. Programmed Cell Death in the Developing Nervous System. Cold Spring Harbor, New York. Contact: Meetings and Courses Madrid, Spain. Contact: Instituto Juan March, Castell6 77, 28006 Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Madrid, Spain. 100, Cold Spring Harbor, NY 11724-2213, USA. Fax: +34 1 576 3420 Fax: +1 516 367 8845 July 1-21, 1996 Email: [email protected] Course: Arabidopsis Molecular Genetics. June 7-27, 1996 Cold Spring Harbor, New York. Contact: Meetings and Courses Course: Molecular Approaches to Ion Channel Structure, Office, Cold Spring Harbor Laboratory, I Bungtown Road, PO Box Expression and Function. 100, Cold Spring Harbor, NY 11724-2213, USA. Cold Spring Harbor, New York. Contact: Meetings and Courses Fax: +1 516 367 8845 Office, Cold Spring Harbor Laboratory, I Bungtown Road, P0 Box Email: [email protected] July 1-21, 1996 July 30-August 12,19% Course: Molecular Cloning ofNeural Genes. Course: Advanced Drosophila Genetics. Cold Spring Harbor, New York. Contact: Meetings and Courses Cold Spring Harbor, New York. Contact: Meetings and Courses Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724-2213, USA. 100, Cold Spring Harbor, NY 11724-2213, USA. Fax: +1 516 367 8845 Fax: +1 516 367 8845 Email: [email protected] Email: [email protected] * July 8-10, 1996 August 14-18, 1996 NFicB/IIcB Proteins. Their Role in Cell Growth, Differentiation and Meeting: Cancer Genetics and Tumor Suppressor Genes. Development. Cold Spring Harbor, New York. Contact: Meetings and Courses Madrid, Spain. Contact: Instituto Juan March, Castello 77, 28006 Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Madrid, Spain. 100, Cold Spring Harbor, NY 11724-2213, USA. Fax: +34 1 576 3420 Fax: +1 516 367 8845 Email: [email protected] July 14-17, 1996 4th IUBMB Conference: The Life and Death ofthe Cell. August 18-23, 1996 Edinburgh, UK. Contact: The Conference Assistant IUBMB 1996, 9th International Congress ofHuman Genetics. The Biochemical Society, 59 Portland Place, London WIN 3AJ, Rio de Janeiro, Brazil. Contact: Congress Secretariat, HOST UK. Eventos e Turismo, Rua Sao Clemente, 407 22260-001 Rio de Fax: +44 171 637 7626 Janeiro, RJ, Brazil July 14-19, 1996 August 18-30, 1996 Gordon Research Conferences: Nuclear Proteins, Chromatin FEBS Advanced Courses: Molecular Mechanisms ofSignalling and Structure and Gene Expression. Targeting. Tilton, New Hampshire. Contact: Gordon Research Center, Spetsai, Greece. Contact: Prof. Dr Karel W. A. 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Contact: Meetings and Courses FEBS Advanced Courses: Basic Methods in Yeast Genetics and Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Molecular Biology. 100, Cold Spring Harbor, NY 11724-2213, USA. Strasbourg, France. Contact: Prof. Dr Jean-Luc Souciet, Fax: +1 516 367 8845 URA-GEM (CNRS and Universite Louis Pasteur), Institut de Email: [email protected] Botanique, 28 rue Goethe, F-67083 Strasbourg, France. August 29-September 3, 1996 Fax: +33 883 58 484 European Research Conferences: Supramolecular Chemistry: July 21-26, 1996 Molecular Recognition and Drug-Receptor Interactions. Gordon Research Conferences: Plant Molecular Biology. Salamanca, Spain. New Hampton, New Hampshire. Contact: Gordon Research Center, Email: [email protected] University of Rhode Island, PO Box 984, West Kingston, RI September 1-6,1996 02892-0984, USA. 12th International Congress on Photobiology. Fax: +1 401 783 7644 Vienna, Austrai. Contact: Vienna Academy of Postgraduate Medical Email: [email protected] Education and Research, Alser Strasse 4, A-1090 Vienna, Austria. July 24-August 13, 1996 Fax: +43 1 405 13 83 23 Course: Advanced Molecular Cloning and Expression of September 1-7, 19% Eukaryotic Genes. Xth Symposium on Chemistry ofNucleic Acid Chemistry Cold Spring Harbor, New York. Contact: Meetings and Courses Components. Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Trest Castle, Czech Republic. Contact: A. Holy, Chairman, 100, Cold Spring Harbor, NY 11724-2213, USA. Organizing Committee, Institute of Organic Chemistry and Fax: +1 516 367 8845 Biochemistry, Flemingovo nam.2, 166 10 Praha 6, Czech Republic. Email: [email protected] Fax:+422 311 1733 July 24-August 13, 1996 September 2-12, 1996 Course: Yeast Genetics. FEBS Advanced Courses: Mechanisms in Eukaryotic Gene Cold Spring Harbor, New York. Contact: Meetings and Courses Regulation. Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Spetses, Greece. Contact: Prof. Dr Horst Feldmann, Institute of 100, Cold Spring Harbor, NY 11724-2213, USA. Physiological Chemistry, University of Munich, SchillerstraBe 44, Fax: +1 516 367 8845 D-80336 Munchen, Germany. Email: [email protected] Fax: t49 89 5996 316 September 4-8, 1996 October 24, 1996 Meeting: Translational Control. Microscopy/Photomicrography. Cold Spring Harbor, New York. Contact: Meetings and Courses Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Parklawn Drive, Rockville, MD 20852, USA. 100, Cold Spring Harbor, NY 11724-2213, USA. Fax: +1 301 816 4364 Fax: +1 516 367 8845 Internet: http://www.atcc.org/workshops/workshop.html Email: [email protected] * October 7-9, 1996 September 10-19,1996 RNA Viral Quasispecies. FEBS Advanced Courses: Structure and Function ofInteracting Madrid, Spain. Contact: Instituto Juan March, Castell6 77, 28006 Protein Domains in Signal and Energy Transduction. Madrid, Spain. Maratea-Acquafredda, Italy. Contact: Prof. Dr Ludwig M. G. Fax: +34 1 576 3420 Heilmeyer Jr, Ruhr Universitiat Bochum, Institut fiir Physiologische Chemie, Abt. fir Biochemie Supramolekularer Systeme, D-44780 October 9-11, 1996 Bochum, Germany. Anticancer Targets and Strategiesfor the 21st Century Fax: +49 234 7094 193 Castres, France. Contact: Marian Cabailh, Conference Secretariat, September 11-13,1996 CRPF, 17 avenue Jean Moulin, 81106 Castres C6dex, France. Cell Culture and Hybridomas: Quality Control and Fax: +33 63 71 42 99 Cryopreservaton Techniques. Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 October 9-11, 1996 Parklawn Drive, Rockville, MD 20852, USA. Growth and Preservation ofAnimal Viruses. Fax: +1 301 816 4364 Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Internet: http://www.atcc.org/workshops/workshop.html Parklawn Drive, Rockville, MD 20852, USA. Fax: +1 301 816 4364 September 15-19, 1996 Internet: http://www.atcc.org/workshops/workshop.html XII International Roundtable: Nucleosides, Nucleotides and their Biological Applications. October 15-18, 1996 La Jolla, California. Contact: P. Dan Cook, ISIS Pharmaceuticals, Freezing and Freeze-Drying ofMicroorganisms. 2292 Faraday Avenue, Carlsbad, CA 92008, USA. Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Fax: +1 619 929 0036 Parklawn Drive, Rockville, MD 20852, USA. Email: [email protected] Fax: +1 301 816 4364 Internet: http://www.atcc.org/workshops/workshop.html September 18-20,1996 Downstream Processing, Recovery and Purification ofProteins November 11-15, 1996 Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Advanced Recombinant DNA Techniques and Applications. Parklawn Drive, Rockville, MD 20852, USA. Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Fax: +1 301 816 4364 Parklawn Drive, Rockville, MD 20852, USA. Internet: http://www.atcc.org/workshops/workshop.html Fax: +1 301 816 4364 Internet: http://www.atcc.org/workshops/workshop.html September 18-22, 1996 Meeting: Molecular Biology ofHepatitis B Viruses. * November 12-14,1996 Cold Spring Harbor, New York. Contact: Meetings and Courses 23rd Symposium on Nucleic Acids Chemistry. Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box Gifu, Japan. Contact: Professor Kosaku Hirota, Laboratory of 100, Cold Spring Harbor, NY 11724-2213, USA. Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Fax: +1 516 367 8845 Mitahora-higashi, Gifu 502, Japan. Email: [email protected] Fax: +81 58 237 5979 0 September 23-25, 1996 November 19-22, 1996 Chromosome Behaviour: the Structure and Function ofTelomeres and Centromeres. Polymerase Chain Reaction Application/Cycle DNA Sequencing. Madrid, Spain. Contact: Instituto Juan March, Castell6 77, 28006 Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 Madrid, Spain. Parklawn Drive, Rockville, MD 20852, USA. Fax: +34 1 576 3420 Fax: +1 301 816 4364 Internet: http://www.atcc.org/workshops/workshop.html September 24-27, 1996 Fermentation Microbiology. April 14-19, 1997 Rockville, MD. Contact: ATCC, Workshop Coordinator, 12301 9th International Congress on Isozymes, Genes and Gene Families. Parklawn Drive, Rockville, MD 20852, USA. San Antonio, Texas. Contact: Ms Daphne Wright, Congress Liaison Fax: +1 301 816 4364 Southwest Foundation for Biomedical Research, PO Box 28147, Internet: http://www.atcc.org/workshops/workshop.htmnl San Antonio, TX 78228-0147, USA Fax: +1 210 670 3337 September 25-29, 1996 Email: [email protected] Meeting: Gene Therapy. Cold Spring Harbor, New York. Contact: Meetings and Courses August 31-September 3, 1997 Office, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 4th Cambridge Symposium Oligonucleotide Chemistry and Biology. 100, Cold Spring Harbor, NY 11724-2213, USA. Cambridge, UK. Contact: Rick Cosstick, The Department of Fax: +1 516 367 8845 Chemistry, University of Liverpool, Liverpool L69 3BX, UK. Email: [email protected] Fax: +44 151 794 3589 Nucleic ACidS Research Volume 23, 1995

OXFORD UNIVERSITY PRESS Subject index

A tracts Antisense DNA molecules containing, sharp reduction in DNA curvature, dehydrating point mutation-selective, design, Ha-ras mRNA, targeting 3419 agents 1816 Antisense effects A:I wobble pair ribonuclease H dependent, single base discrimination, leukaemia cells inefficient decoding 683 954 Abasic DNA cleavage Antisense oligonucleotides novel reagents 1664 cooperative, design, properties 3578 ABF1 Antisense phosphorothioate oligomer Saccharomyces cerevisiae, DNA binding domain, structure-function RelA/NF-cB, sequence context, specificity 1146 analysis 2980 AP2 transcription factor Actinophage 4C31 binding inhibition, sulphur mustards 4378 early region, rho-independent terminators 370 Apurinic endonuclease Actinophage RP3 trans-complementation, DNA damage, spontaneous mutator phenotype site-specific integration into tRNAArg (AGG) gene, Streptomyces rimosus 5027 58 Archae Active amber tRNAASn promoter recognition, transcription factors 3837 genetic selection, glutamine inserting suppressors 779 Archaean genomes Acyclic 5-nitroindazole nucleoside analogue novel protein families 565 ambiguous nucleoside 4363 Arrayed cosmid libraries Adenovirus ElA screening, mega insert YACs 1085 YY1, functional interactions 925 Artificial mini-chromosomes Adriamycin trypanosome, construction 4893 interstrand crosslinks, site defining 2450 ASF/SF2 Affinity purification Ul snRNP, interaction, 5' splice site recognition, required elements, DNA-binding proteins, bromoacetyl agarose, methods 2344 characterization 3260 Albumin mRNA Asymmetric PCR mouse, specific endonucleolytic cleavages, liver development 641 efficient amplification, use of 'megaprimer', method 4530 Alphoid Sau3A repeat family AT-rich element extrachromosomal copies, recombination site preference 4971 identification, link protein gene, regulation 2305 Altered gene expression ATF-1 cataloging, enhanced differential display 3244 and CREB-1, transcription factors, binding, hypoxia-inducible factor- Alternative splicing 1(HIF- 1) 4542 MADS box genes, ZEMa 2168 ATF-1/CREB heterodimer Alu expression involvement in constitutive expression, Na,K-ATPase al subunit gene affected by RNA polymerase III promoter and terminator elements 2848 1750 att DNA binding domain Alu sequences phage Mu transposase, mutational analysis 3937 short well-conserved region, in gene rearrangement, homology with Avian TdT prokaryotic chi 256 T-cell specific, recombinant enzyme, cDNA, characterization 2041 2'-Amido-nucleosides Azole-substituted oligonucleotides in oligodeoxy-and oligoribonucleotides, model for 2'-linked conjugates antiparallel triplex formation, duplex targets 647 51 B23 Aminoacyl-tRNA synthetase nucleolar protein, ribonuclease activity 3974 activity measurement, continuous spectrophotometric assay, broad BAC library applicability 2886 chromosome-specific clones, identification, colony hybridization-based Aminoacyl-tRNA synthetases approach, method 1838 high motif, transition state stabilization 4793 Bacterial expression screen synthesis, cysteine containing dipeptides 4608 interaction with c-myc, identification of cDNA, method 269 Aminoacyl-tRNAs Bacterial methyltransferase(M.EcoHK311) at sense codons, selection, context effect 4104 two proteins for methylation 103 2-Aminopurine Bacteriophage P1 in DNA duplexes, interactions, restricted endonucleases 2192 lytic replicon, control by antisense RNA 1468 AMLI gene Basal in vitro transcription alternative splicing, genomic structure 2762 inhibition, distamycin A, tallimustine 1657 Amplicons Base-amino acid interactions circular and linear, co-existence, Leishmania, methotrexate-resistant in DNA, consistencies, structures, sequences 4707 2856 Base dynamics Amyloid n-protein precursor gene effects of sequence context, TpA steps, NMR 3962 APBa sequence, USF binding 2734 Base pair opening Androgen receptor energetics, DNA dodecamer, A3T3 tract 1984 allele amplification, PCR bias, clonality studies 1411 Bending a Anomers stereochemistry-dependent, oligonucleotide duplexes 2314 triplex formation, oligodeoxynucleotides, purine-and pyrimidine-rich Benzo[a]pyrene-7,8-dihydrodiol-9 10-epoxide 4042 adducts, site-and stereo-opecific, in vitro replication, polymerases 1398 Anti-HIV oligodeoxynucleotide Binding kinetics monoclonal antibody, half-life extension, targeted to CD4+ cells 4603 antisense RNA, plasmid primer RNA, metastable structure influence Antibody fragment expression 3718 in mutant Ecoli, method 4010 Biomolecular interaction analysis Antirestriction functions oligodeoxynucleotides triplex formation, detection, kinetic studies, plasmid encoded, possible mechanism of action 785 method 3627 Antisense 2'-O-alkyl oligoribonucleotides Bis-PNAs reverse transcription, efficient inhibition 64 pH-independent, sequence-specific DNA binding 217 Subject index

DNA heteroduplex analysis DNA synthesis short insertions, partner strands, greater discriminatory power, methods barrier, CGG repeats, intrastrand tetraplexes 4202 2078 high-throughput, multichannel format 982 DNA homoduplex RNA-primed, initiation in vitro, DNA polymerase a-primase 1003 parallel-stranded, formation, d(GGA) repeats 3771 DNA topoisomerases DNA hypomethylation mutant and site-specific recombinases, novel suicide substrate 2973 Arabidopsis thaliana, characterization 130 DNA transfection DNA intrastrand cross linking calcium phosphate suspension, method 3609 8,5'-cyclodeoxyadenosine formation, theoretical analysis 515 DNA transformation DNA ligase I DNA gyrase, large recombinant plasmids, method 3353 late induction after UV-C irradiation 962 DNA triple helices DNA marker order formation of, DNA unwinding inhibition, SV40 large T-antigen helicase fine-scale, conservation, rice, Triticeae 2724 1292 DNA melting DNA unwinding intramolecular, stable helical segments, melting theory, metastable states SV40 large T-antigen helicase, inhibition, formation of DNA triple 2775 helices 1292 DNA methyltransferases DNA(cystosine-5)methyltransferase HhaI and HpaII, DNA mismatch binding, uracil methylation, blockage slipped duplexes, snapbacks, cruciforms 1584 of DNA repair 1380 DNA-adducts M.HhaI, tight substrate binding, mismatches at target base 1388 adriamycin-induced, stability 42 DNA minor groove DNA-binding domain width variability, ligand binding, crystal structure 3678 novel, zinc finger motif 3411 DNA nanostructure DNA-binding proteins G-wire, imaged by scanning probe microscopy 696 affinity purification, bromoacetyl agarose, methods 2344 DNA nicks histone fold motif 2685 heat-generated, repair, Xenopus egg lysates 1396 isolation, micro-scale method, transfected cells 3607 DNA photocleaving agents DNA-targets high sequence specificity, related to bleomycin A2 1524 catalytic site-specific cleavage, oligonucleotide carrying bleomycin A5 DNA polymerase a 4400 calf thymus, interactions, primer/templates 4109 DnaA box R4 cell cycle stages, studies, Schizosaccharomyces pombe 4337 oriC, chromosome replication, Escherichia coli 3119 DNA polymerase 0 DNase I digestion specific inhibition, 14 kDa domain, DNA binding, 5'-phosphate random recombination, method 3067 recognition 1597 DNase I sensitivity analysis strategic down-regulation, antisense RNA, sensitivity to damaging agents rat growth hormone gene, chromatin, enhancer activity 2236 3810 DNase isolation DNA polymerase e trypanosomatid Crithidia fasciculata, monomeric and multimeric forms and polymerase £, structural relationship, occurrence in eukaryotic cells 4426 244 Double-strand breaks expression, cell proliferation, characteristics 2178 SI, mung bean and P1 nucleases, abasic sites and nicks 3805 DNA polymerase I Drosophila immunity Thennus aquaticus, DNA synthesis, template switching 2049 diptericin promoter, enhanced activity, region homologous to NF-kcB and DNA polymerase III holoenzyme NF-1L6 response elements 1140 Xr subunit, Escherichia coli, annealing activity 1374 Drosophila melanogaster DNA polymerases North American populations, microsatellite variation 3882 prokaryotic and eukaryotic, sliding clamps, similarities 3613 Duplex DNA DNA quadruplexes major groove polarity, minor groove interactions, fluorescent probes manganese binding sites, determination in solution, EPR, NMR 844 159 DNA quantitation recognition, RNA polynucleotides 500 internally standardized, low stringency PCR, method 192 Duplex DNA and RNA DNA repair stabilities, effect of site-specific substitution, 5-fluoruridine 3916 RAD54 and UNGI genes, cell cycle regulation, MCB promoter elements Duplex targets 2147 azole-substituted oligonucleotides, antiparallel triplex formation 647 yeast transcription factor TFIIH, Tfbl and Ssll subunits, interaction E.coli methionine repressor-operator complex 767 effect of co-repressor, molecular mechanism, surface plasmon resonance DNA replication 211 site-specific initiation, Physarum rDNA, non-transcribed spacer 1447 Eo&8 RNA polymerase promoter determinants, E.coli 827 DNA sequence assembly selectivity for overlapping promoters, supports CRP activation, Ecoli new program 4992 819 DNA sequence protection Eco KI methyltransferase triplex-bridge formation 452 DNA contacts, altered by S-adenosyl methionine 967 DNA sequencing projects Electroporation base calling accuracy, application of numerical estimates 1406 in situ, mammalian cells, grown on microporous membranes, method frameshift error detection algorithm 2900 2803 DNA site-specific recombinases transformation frequency, low temperature growth, Escherichia coli, and topoisomerases, novel suicide substrate 2973 method 1641 DNA strand breaks transformation of E.coli, large DNA molecules 1990 bleomycin-induced, characteristics, shuttle vector system 3224 Embryonic stem cells oxidative stress, 3'-phosphoglycolate termini 2995 culturing, hygromycin-resistant feeder layers, method 1273 DNA strand transfer marking, lacZ-hygromycin fusion gene, gene trap vector, method 4004 catalysis, DNA polymerase I, Escherichia coli 4620 vector insertion, gene conversion 2058 DNA supercoiling EMSA effects of par locus in vivo, plasmid replication origin 701 biotinylated probes, RNA-protein interactions 3792 Subject index

Encephalomyocarditis (EMC) virus RNA Gal4 transcription factor binding site localization for polymerase 377 binding domains, interaction with c-Jun transcription factor, zinc-finger 3-end processing and bZip motifs 588 G-rich sequence downstream region, sequence and position requirements a-Galactosidase RNA 1625 human, editing, pyrimidine-*purine 2636 Endonuclease G GC content from mammalian nuclei, identical to Mg2+-dependent mitochondrial Escherichia coli genes, replication timing, repair mechanisms, endonuclease 88 correlation 1350 Enhancer elements GCN4 identification, downstream of c-myc gene 72 comparison with C/EBP, DNA binding specificity 4162 Epstein-Barr virus GCN4 mRNA BZLF1 transactivator, interactions with RARa and RXRa 1729 translational reinitiation, sequence requirements 3981 Equine infectious anemia virus 2-D gel analysis TAR RNA element, NMR analysis 4058 replication intermediates, rapid DNA preparation, method 3998 Erythropoietin receptor gene Gel electrophoresis transcription, regulation, GATA-1 and SpI motifs 3041 double bands, bis-intercalating dyes 2413 Escherichia coli genotyping, temporal thermal gradient, oligonucleotide dissociation genome VI, analysis, 92.8-100 minutes region 2105 2404 low temperature growth, transformation frequency, electroporation, Northern blotting, RNA, simple procedure 3357 method 1641 Gene activation Escherichia coli genes recombinant adenovirus, site-specific Cre recombinase 3816 weak expression, replication timing, repair mechanisms, correlation of Gene conversion GC content 1350 vector insertion, embryonic stem cells 2058 1,N6-ethenoadenine repair Gene detection 3-methyladenine DNA glycosylases 3750 bacterial genome, Markov models 3554 Eukaryotic mRNAs Gene expression 5'-untranslated leader sequences, heat shock proteins 541 dexamethasone inducible, glucocorticoid antagonists, methods 2342 Expression vector cassette Gene expression fingerprinting large scale isolation, magnetic triple helix affinity capture, method 3996 restriction endonuclease-based, differentially expressed genes, Feature mapping identification 2954 construction from nested deletions 117 Gene fusion junctions Fecal DNA preparation isolation, sequencing, kplacMu specialized transducing phage, method for PCR, method 3800 3076 FGF-1 gene Gene targeting expression, vascular smooth muscle cells, response to serum and phorbol loxP-flanked genes, deletion, cre-transgenic mouse strain, method 5080 ester 434 stimulation, double strand breaks, target locus, embryonic stem cells Fibronectin 5012 regulation of expression, rat regenerating liver 238 target site transcription, effects, in vitro 2784 Fibronectin gene Gene therapy rat, enhancer, identification, tissue-specific regulation 3335 strategy for mitochondrial DNA diseases, mitochondria transfection 10 FISH analysis Gene transcription YAC DNA preparation and labelling, method 720 activation, UBF nucleolar factor, phosphorylation 2593 Fission yeast gene pmtl + composite regulatory elements, a compilation 4097 encodes DNA methyltransferase homologue 203 Gene transduction Flp recombinase retrovirus-mediated, enhanced efficiency, transient overexpression, analysis, chemical probe, missing nucleoside 3009 GLVR-2 2080 Fluorescence correlation spectroscopy Genome amplification ultrasensitive hybridization analysis 1795 genotypic analysis, somatic cells, loci 3496 Fluorescent 2'-deoxyisoinosine Genome analysis in oligonucleotides, solid-phase synthesis, duplex stability 2499 base cutter, Sse83871 2367 Fluorescent guanosine analog Genomic DNA oligonucleotide incorporation, real time assay, HIV-1 integrase 3'- extraction, one-tube, PCR and RAPD analyses, method 2569 processing reaction, method 2872 high quality, isolation, method 5087 Foamy virus potential cruciform and H-DNA forming sequences 1977 human, reverse transcriptase, ribonuclease H, mutational analysis 2624 sequencing, efficient strategy, shotgun template-libraries, fine-mapping -1 frameshifting 3842 simultaneous slippage mechanism, post-rather than pre-translocational, Genomic footprinting HIV-1 gag-pol overlap 1487 Drosophila embryos, hsp7O and his3 promoters, DNA-protein Fusion phage-substrate complexes interactions 3327 dissociation constants, measurement via phage titre 1531 G+A sequencing ladders Genotypic analysis generation, express protocol 310 somatic cells, loci, genome amplification 3496 G-rich sequence P-Globin gene downstream region, 3'-end processing, sequence and position human, mutation, splicing efficiency, hnRNP C interaction 3427 requirements 1625 human, transcription initiation rate, TBP binding 3481 G-wire nonsense mutations, nuclear degradation, 1-thalassemia, implications for DNA heterozygotes 413 nanostructure, imaged by scanning probe microscopy 696 Glucocorticoid responsive element GABA utilization characterization, link protein gene, regulation 2305 gene induction, cis-and trans-acting elements, Saccharomyces cerevisiae Glycine tRNA synthetase gene 550 human, cloning, sequencing, bacterial expression 1307 gal operon fragment Group I introns base pair opening, spermine binding, protein-DNA recognition, defines upstream cleavage site, conserved wobble pair, divalent metal implications 2065 ion binding 341 Subject index

ribozyme activity, bidirectional effectors 1284 Histone-U7 RNA splice site, CG instead of UG basepair, post-translation selection? 4466 chimeric, synthetic, cis-cleavage, Xenopus oocytes 3152 Group I ribozymes Histone fold motif 3' splice site reactions, novel analysis system 849 DNA-binding proteins, multimeric proteins 2685 Group II intron Histone genes splicing, chimeric reporter gene, tobacco plastids 2544 H2A and H3, mouse, conserved element, coding region 3083 Guanine Histone Hi 2-amino group, transfer to adenine, antibiotic binding 885 DNA and chromatin, in vitro replication 773 Guide RNAs reconstituted nucleosome arrays, effect on transcription, T7 RNA secondary structure, Trypanosoma brucei 3093 polymerase 1075 Guthrie card DNA Histone H10 gene enhanced amplification, PCR inhibitors, selective elution, method 3788 transcription modulation, thyroid hormone receptors 5034 H-ras proto-oncogene Histone mRNA mammalian assay, site-specific DNA damage processing 2269 3' end, stem and flanking sequences, critical determinants, stem-loop H3abp complex binding protein 654 protein identification, specific DNA-binding component, histone Histone promoter site promoter site, Gl/S regulation 475 GI/S regulation, H3abp complex, protein identification, specific DNA- H5S gene binding component 475 nucleosomal repression, prevention by hTFl11 A 109 HIV reverse transcriptase Hairpin opening orientation of binding, nucleic acid hybrids 3901 single-strand specific nucleases 3872 HIV-1 Hairpin properties nucleocapsid protein, annealing activities, analysis 2434 single-stranded DNA containing (CTG)15 1050 reverse transcriptase, mutational sensitivity, critical residues 803 Hairpin structures reverse transcription, inhibition, triple-helix formation 1204 topoisomerase II, IH-and 31P-NMR 3850 HIV-1 gag-pol overlap Hairpins -1 frameshifting, simultaneous slippage mechanism, post-rather than and disulfide cross-linked analogue, solution structure 2153 pre-translocational 1487 formation, d(CAG)15, d(GAC)15 4055 HIV-1 integrase stability, palindromic oligonucleotides, comparisons 4576 deoxyuridine mismatches, abasic site, processing 2865 stabilized by GA/CG helix unit, occurrence, solution structure, stability 3'-processing reaction, real time assay, fluorescent guanosine analog, 4717 oligonucleotide incorporation, method 2872 UNCG tetraloop, ultra stable, RNA folding, applications 3056 HIV-1 replication Hammerhead ribozyme domain inhibition, target sequence-specific, ribozymes, tat RNA 2609 catalytic activity, DNA-oligomer 4092 HIV-1 retrovirus Hammerhead ribozymes replication, misaligned tRNA-primer, efficient extension 1319 all-RNA, DNA-armed, in vitro activity, a comparison 3928 HIV-1 reverse transcriptase conformational characteristics, determination, mutagenesis, lattice large subunit, interaction with j-actin 736 calculation 3531 HLA-DRA gene mediated cleavage, hepatitis B virus encapsidation signal 4954 upstream region, sequencing, X' and Y' boxes 1671 incorporation of 2'-modified nucleotides 4434 HLH gene family minimised (minizymes), in vitro activity 3922 MEl gene, regulation of expression, novel initiator 1696 substrate recognition helices, base mismatches, effect on binding and HMG-1 box catalysis 2092 structural domain, homology model building 1019 target motif, cleavage rates, comparative analysis 1192 HMG-1 box protein family HAP1 classification, functional relationships 1604 site directed mutagenesis, AP endonuclease and RNase H activity, HMGI-C human protein important residues 1544 gene, five exons, distinct functional elements 4262 Heat shock factors HNF-1 binding, activation, Drosophila 4799 -3 and -4, a-l-microglobulin/bikunin precursor, hierarchy, positive/ murine, complex expression 467 negative interplays 394 Heat shock proteins Homeodomain protein eukaryotic mRNAs, 5'-untranslated leader sequences 541 AKR, chicken, isolation, characterization 3252 Hepatitis B virus Homologous recombination bulge in encapsidation signal, distinct sequence requirements 3909 improved technique, site-directed mutagenesis, method 1642 encapsidation signal, hammerhead ribozyme-mediated cleavage 4954 Hoxll protein Hepatitis delta agent optimal binding sequence, predicted recognition core motif 1928 antigenomic ribozyme, 3-D models 4180 HpaII methyltransferase ribozyme control element, tertiary structure, Tm studies 4391 mutator enzyme, mutant 4275 RNA tertiary structure, UV-sensitivity, bimolecular complex 491 hrpA gene Hepatocyte nuclear factor 3 Escherichia coli terC region, cloning, characterization 595 P protein domains, analysis 1184 HhaI methyltransferase HSC82 Gln-237 mutants, functional analysis 620 heat shock gene promoter protein-DNA interactions 1822 High resolution SSCP Hsp26 promoter temperature optimization, transverse TGGE, method 4524 Drosophila, dual regulation 2479 High stability triple helices HSV a gene promoters short purine oligonucleotides, SIV/HIV-2 vpx genes, targeted DNA transcription factors, interactions, sensory neurons 4978 structure 3831 hTFlllA Histidine tRNA prevention of nucleosomal repression in hSS gene 109 Saccharomyces cerevisiae, identity elements 389 Human nerve growth factor Histidine-tagged fusion proteins RNA ligands, high affinity 3198 detection, monoclonal anti-histidine tag antibody, method 3347 Human p53 Histone-DNA interactions expression in Leishmania cells, biologically active, recombinant proteins triple helix DNA, nucleosome barrier 2184 4073 Subject index

Human papillomaviruses LSIRF, molecular cloning 2127 DNA replication, control, transcription factors 4777 Interferon-induced transcript Human ribosomal protein L7 splice donor sites, novel minisatellite, characterization 1854 inhibition of cell-free translation, effect on expression of nuclear Internal eliminated sequences proteins 195 Paramecium, consensus inverted terminal repeat sequence 2006 Hybridization Interstrand crosslinks between synthetic oligonucleotides and RNA, characterization 4946 adriamycin-induced, stability 42 2-Hydroperoxytetrahydrofuran Intra-chromosomal rearrangements as a reagent, sequencing cytosine, non-Watson-Crick DNA probing, Cre-lox site-specific recombination 485 method 713 Intramolecular triple helices 2-Hydroxyadenine chimeric DNA-RNA, 29mer RNA, spectroscopic studies 1722 misincorporation of dAMP 761 Intron evolution 8-Hydroxyadenine oligodeoxyribonucleotide evidence, chloroplast genes, Euglena 4745 DNA synthesis, misincorporation, NIH 3T3 cells, mutagenesis 2893 Intron splicing 2'-Hydroxyl protecting group enhancement, chicken 3-tropomyosin pre-mRNA 3501 new, automated synthesis, oligoribonucleotides 4872 Iododoxorubicin Hypotrichs anti-cancer drug, complexed with d(TGTACA) and d(CGATCG), macronuclear gene-sized molecules, survey and summary 1279 molecular structure 4488 Hypoxia-inducible factor-l(HIF-1) Ion-exchange displacement chromatography binding, transcription factors, ATF-1 and CREB-1 4542 phosphorothioate oligonucleotides, gram-scale purification 2292 HYS2 gene Iron-responsive element DNA replication, Saccharomyces cerevisiae 3403 in ferritin mRNA, hairpin loop structure, an NMR study 146 Hz-I virus RNA secondary structure, translational regulation, ferritin synthesis insect, very early promoter, identification, dual-expression shuttle vector 4190 4683 Isopropanol precipitation IrcB homologue removes PCR inhibitors, ancient bone extracts, method 881 Drosophila, biosynthesis, stability, dorsal protein 3111 Isotopic enrichment ICRE-dependent gene activation selective, RNA, synthesis, NMR 4913 FAS binding factor 1, Ino2p and Ino4p 230 Junction loops ID repeat family multi-helix, relative stabilities 2212 rodent, transcription, processing, germline and somatic cells 2245 Keratin gene Idarubicin:d(CGATCG) complex Xenopus, protein-DNA interactions, tissue-specific 4502 trigonal form, crystal and molecular structure, 2A resolution 1710 lac promoter IFN-A genes transcription activation, role of CRP, Escherichia coli 599 virus-induced transcription, PRDI and TG-binding activity 5055 lac repressor-operator complexes Ig heavy chain stability, agarose-based gel matrix, methods 2346 novel enhancer element identified, regulated at B cell differentiation stability, central base pairs, modified nucleotides 1502 975 lacZ-hygromycin fusion gene Ig/EBP gene trap vector, marking embryonic stem cells, method 4004 transdominant negative inhibitor, C/EBP family transcriptional activators Leishmania 4371 and Leishmania RNA virus, phylogenetic analysis, virus-parasite IL-4 responsive element association 2300 novel, Ea MHC class II promoter, inducuble factor, binding 2919 Library plasmids Immediate-early protein IE62 identification, yeast transformants pool, method 4222 varicella-zoster virus, mutational analysis 1341 Ligase chain reaction Immunodepletion EMSA modification, point mutation detection, method 675 protein identification, protein-DNA complexes, method 3345 LINE-like element Immunoglobulin novel, Drosophila melanogaster 1354 switch regions, transcription, RNA-DNA complexes, formation 5006 Link protein gene Immunoglobulin e mRNAs regulation, characterization of glucocorticoid responsive element, characterization, polyadenylation sites 4805 identification of characterization 2305 Immunoglobulin X light chain gene Linkage isomerization reaction chicken, transcriptional control 1997 intrastrand crosslinks, single-stranded oligonucleotides, trans- 'n-i' impurity diamminedichloroplatinum(II)-modified 949 f-cyanoethyl phosphoramidite, ,B-cyanoethyl phosphoramidite solid- 15-lipoxygenase gene phase synthesis method, stepwise sulfurization 2754 rabbit, regulation, transcriptional silencer 3664 in vitro transcription Looped oligodeoxynucleotides close to melting point of DNA, analysis using chemical probes 988 selective binding, in vitro replication 4255 Initiation factor of eIF-4'y Looped oligonucleotides proteolytic cleavage, translation inhibition of capped mRNAs 334 single-stranded DNA, stable hybrid complexes 1170 Initiators Low X5 and TdT, repression by c-myc protein 1 stringency PCR INOI gene internally standardized DNA quantitation 192 transcription, negative and positive, regulation, Saccharomyces LSIRF cerevisiae, study with INOI-JOO allele 1426 interferon regulatory factor family, molecular cloning 2127 INOI gene expression M-lysozyme gene regulation, SIN3, two promoter elements 1964 mouse, downstream enhancer, methylation, GABP binding 4785 Integration host factor M13 libraries Escherichia coli, in vivo interaction, specific binding sites 2959 construction, analysis, YAC DNA 670 Interference footprinting Macronuclear development simultaneous analysis, protein-phosphate and protein-guanine contacts, studied in Stylonchia lemnae 1704 method 1443 MADS-box genes Interferon regulatory factor family Zea mays, chromosomal mapping 1901 cIRF-3, induction by dsRNA 2137 ZEMa, alternative splicing 2168 Subject index

Magnetic triple helix affinity capture Mitochondrial endonuclease large scale isolation of expression vector cassette, method 3996 Mg2+-dependent, identical to endonuclease G(from mammalian nuclei) MALDI spectra 88 matrix for oligonucleotides, 6-aza-2-thiothymine, method 1276 Mitochondrial genome Mammalian interspersed repetitive element Caenorhabditis elegans, frequency of deletions, increase with age 1419 mammalian genes, coding, sequence processing 2837 Mitochondrial RNAse P RNA Mammalian SINE transcripts structure, function, biosynthesis, RPM] gene, yeast mitochondria abundance, affected by cell stress and translational inhibitors 1758 transformation 856 Mammalian-wide interspersed repeats (MIRs) Mitochondrial tRNAASP molecular fossils from mesozoic era 170 maturation, in marsupials 3380 tRNA-derived SINEs 98 Modified curved DNA Markov models local DNA underwinding, nucleosomal pseudodyad, nucleosome gene detection, bacterial genome 3554 positioning 4170 Mass spectrometry 2'-Modified nucleotides matrix-assisted laser, desorption/ionization, duplex DNA probes 3126 enzymatic synthesis, methods 1845 matK protein synthesis, incorporation, hammerhead ribozymes 4434 RNA-binding activity, chloroplast trnK intron 917 Modular primer effect Matrix-assisted laser desorption mass spectrometry mechanism 2881 rapid DNA sequencing, 7-deaza analogues, guanosine, adenosine, Mouse silver mutation method 1570 Pmel 17 gene, single base insertion, putative cytoplasmic domain 154 mdm2 gene mRNA human, p53-responsive intronic promoter 2584 deregulated expression, T cell apoptosis 4857 ME1 gene mRNA decay HLH gene family, regulation of expression, novel initiator 1696 endonucleolytic cleavages, coding region 4885 MEF2 proteins mRNA polynucleotide vector expression, muscle and non-muscle cells 4267 Sindbid virus, heterologous gene expression, prolonged, high level 1495 Megabase DNA mRNA population protection from shearing, method 4000 description, 3' end cDNA fragment generated by class II restriction Melatonin enzymes 3685 nuclear receptors, synthetic ligand identification 327 mRNA quantitation MelR transcription activator PDAI mRNA superior to ACT] mRNA, S.cerevisiae, method 883 Escherichia coli, stable fragment, DNA binding domain 1518 mRNAs Melting theory 3' untranslated regions, discordant expression, variable triplet repeat intramolecular DNA melting, stable helical segments, metastable states numbers, PIGR gene 1098 2775 MSN3(STD1) Metalloporphyrin-linker oligonucleotides interaction, TATA-binding protein, SUC2 gene, transcription 3174 double-stranded DNA cleavage, linker influence 3894 MTF-1 Metastable states transcription regulator, heavy-metal responsive, functional domains intramolecular DNA melting, stable helical segments, melting theory 2277 2775 Multi-gene families 8-Methoxypsoralen sequencing, novel method 3074 photoinduced plasmid-chromosome recombination, centromeric vector, Multianalyte immunoasay Saccharomyces cerevisiae 1614 high sensitivity, covalent DNA-labelled antibodies, PCR, method 522 Methylation Multimeric proteins N-6-adenosine, spliceosomal U6 small nuclear RNA, HeLa cell extract histone fold motif 2685 2421 Mutagenesis slipped duplexes, snapbacks, cruciforms, DNA(cystosine- site-directed, homologous recombination, improved technique, method 5)methyltransferase 1584 1642 Methylation specificity Mutation detection determination of, DsaV methyltransferase 29 enzyme mismatch cleavage modification, method 5082 5-Methylcytosine immobilized mismatch binding protein (MutS), method 3944 difference detection, restriction enzyme isoschizomers, method 4740 MyD88 enzymic removal, poly(dG-5-methyl-dC), Hela nuclear extracts, nuclease primary response gene, 5' upstream sequences, functional IRF-1, Stat 1621 factors binding sites 3539 in DNA, oxidative damage 3239 myoD gene 5'-Methylenephosphonate analogues expression, effect of COUP-TF II(orphan steroid receptor), myogenesis synthesis, new approach 893 1311 MGSA/GROa gene Myogenesis regulation, HMGI(Y), Spl, NF-cB 4210 effect of COUP-TF II(orphti steroid receptor), myoD gene expression a-l-Microglobulin/bikunin precursor 1311 HNF-1, -3 and -4, hierarchy, positive/negative interplays 394 j Myosin heavy chain gene Microsatellites 5' upstream region, position independent expression, developmental hybridization to RAPD, source of polymorphic markers, method 3798 regulation, transgenic mice 3301 Mimosine N-6-Adenosine binding to a 50 kDa protein, Chinese hamster cells 261 methylation, spliceosomal U6 small nuclear RNA, HeLa cell extract Miniexon arrays 2421 Crithidia fasciculata, site-specific elements, novel non-LTR Na,K-ATPase al subunit gene retrotranspon 2929 constitutive expression, ATF-1/CREB heterodimer involvement 2848 Minor groove binding ligands Nascent peptide chain AT-selective, sequence preferences 3385 path mapping, 23S RNA, 50S ribosomal subunit 2371 Mitochondria NCB protein transfection, strategy for gene therapy(mitochondrial DNA diseases) 10 interacting factors, identification 3638 Mitochondrial DNA NDP-kinase B rearrangements, number, variety, aging human skeletal muscle 4122 specific binding, single-stranded polypyrimidine sequences 3858 Subject index

Neural network models Oligohistidine ribosome binding sites, Escherichia coli 1632 fusion proteins, quantitation, 63Ni2+ chelation, method 3069 New gene family Oligonucleotide circularization translational regulation, cellular and viral RNA 2120 disulfide bridge formation 2025 NF-iB Oligonucleotide generation DNA binding, conformation changes 3393 with site-specific UV photoproducts, immunoprecipitation 4934 NFKB2 gene Oligonucleotide hybridization promoter regions, characterization, structural and functional 2328 hetero-and homoduplex, 2'-modified, characterization, nuclease NF-cB-Rel A sensitivity 2019 inhibition, suppressed uPA synthesis, no effect on PAI-i 3887 Oligonucleotide probes NF-Y detection, dioxetanes, photochemical amplification 4657 and SpI glutamine-rich activators, cdc25c transcription cell-cycle Oligopurine tracts regulation 3822 long, overabundance in genome, eukaryotes 689 Nicotinamide mononucleotide Oligoribonucleotides in polymers, enzymatic synthesis 3742 automated synthesis, 2'-hydroxyl protecting group 4872 Nitrogen mustard 5'-diphosphorylated, solid-phase synthesis, conversion, capped inhibition, transcription, translation, cell free system 3508 (m7Gppp)-oligoribonucleotides, primers 2641 5-Nitroindole synthesis, mouse DNA primase-catalyzed, stimulation, DNA helicase B and 3-nitropyrrole, universal bases, primers, DNA sequencing, PCR 2014 2361 Open promoter complexes 3-Nitropyrrole structure, DNase I footprinting, compilation analysis, survey and and 5-nitroindole, universal bases, primers, DNA sequencing, PCR summary 4533 2361 oriC 1H-and 31P-NMR DnaA box R4, chromosome replication, Escherichia coli 3119 hairpin structures, topoisomerase II 3850 Orphan nuclear receptors NMR characterization ARP-1, transcriptional activation 1536 triple stranded complex, homopurine and homopyrimidine DNA 4116 Orphan steroid receptor Nomenclature COUP-TF II, regulatory function, myoD gene expression, myogenesis junctions, branchpoints, survey and summary 3363 1311 Non-LTR retrotransposon Orphon spliced leader sequences R4, specificity, large subunit, rRNA genes, nematodes 4628 repetitive element, Angiostrongylus cantonensis 1030 Novel enzymatic pathway Osteocalcin gene 1-methylinosine modification, tRNA, Haloferax volcanii 4312 silencer element, characterization 5064 Nuclear ASF-1 activity Oxidative base damage TGA factors, differential representation, binding site requirements 3778 RNA, detection, reverse transcriptase 3275 Nuclear factors 6-Oxocytidine Trypanosoma brucei, binding, tRNA genes, DNA bending 3103 protonated C-base analogue, stable triple helix formation 3473 Nuclear localization signals 32P-postlabelling method nucleic acid-binding proteins, DNA-or RNA-binding domains 1647 platinum-DNA adducts detection 1300 Nucleases p255 single-strand specific, hairpin opening 3872 nuclear matrix phosphoprotein, splicing complexes, association 3206 Nucleolar protein p50 homodimer B23, ribonuclease activity 3974 introduces virtually no bend in DNA 427 gar2, 18S rRNA, 40S ribosomal subunit, accumulation, p53 binding Schizosaccharomyces pombe 1912 middle and C-terminal domains, internal DNA segments and ssDNA Nucleolar RNA ends 362 intron-encoded, U24, 28S RNA complementarity 2669 p53 promoter Nucleoside-methyl[CT3]phosphonamidite mouse, upstream region, critical for transcriptional expression 663 synthesis, biodistribution and biostability studies, method 3600 p53 tumor suppressor Nucleosomal DNA alternatively spliced, expression, species-and tissue-opecific 4023 association, TBF/TFIIA, TATA box position, core histones, N-terminal p53 tumour suppressor tails 4557 plasminogen activator and inhibitor gene transcription, differential Oct-i POU-specific recognition helix regulation 3710 altered DNA binding, adenovirus DNA replication enhancement 3189 Parathyroid hormone/parathyroid hormone related peptide receptor Octameric palindrome(HIP1) gene over-representation, cyanobacteria 729 tissue-sepcific and ubiquitous promotors 1948 Oestrogen receptor PARP promoter ligand-binding domain(modified), heterologous proteins, regulation activation of VSG expression site promoter, trypanosomes 1010 1686 PCR Oligo(deoxynucleoside phosphorothioate)s and PCR sequencing, postassium-free buffers, eliminates premature analysis, diastereomeric composition 530 chain termination, method 539 2',5'-Oligoadenylate differential display, novel findings, novel applications, method 1832 phosphorodithioate analog, synthesis, biological activity 3990 improved method, uncloned genomic DNA 1087 Oligodeoxynucleoside phosphorodithioates product, unequal length strands, method 4220 and phosphorothioates, stability, aqueous ammonia, method 3349 product size increase, methods 2337 Oligodeoxynucleotides single tube two-round, product carry-over, prevention, method 4736 triplex formation, detection, kinetic studies, biomolecular interaction with detachable primers, method 1083 analysis 3627 yield and specificity, tetramethylammonium chloride, concentrations, Oligodeoxyribonucleotide 14mer duplexes method 3343 boron-containing, enzymatic synthesis, melting studies 4495 PCR amplification Oligodeoxyribonucleotide N3'-*P5' phosphoramidates enhanced, DlS80 locus, PNA 3050 synthesis 2661 single-step, solid tissues, method 1640 Oligodeoxyribonucleotide phosphorothioate analogues PCR bias preparation, new sulfurizing reagents 4029 androgen receptor allele amplification, clonality studies 1411 Subject index

PCR in situ PLS20 plasmid minor base deletion mutant, differentiation from normal, method 3790 Bacillus subtilis, replication region, characterization 3214 PCR inhibition Plum pox potyvirus attenuation, plant compounds, BLOTTO, method 2567 CI protein, RNA helicase activity, RNA binding domain mapping 1327 by uv-damaged mineral oil, overcome by hydroxyquinoline, method Pmel 17 gene 4002 single base insertion, putative cytoplasmic domain, mouse silver PCR products mutation 154 isolation, reversible immobilization, solid phae, method 4742 PNA rapid detection, fluorescent intercalator, pyrylium dye, method 1445 enhanced PCR amplification, DIS80 locus 3050 unpurified, dye-labelled primer cycle sequencing, methods 2348 PNA strand invasion PCR targeting NF-icB specific transcriptional activation, inhibition 3003 micro-homology mediated, Saccharomyces cerevisiae, method 2799 Point mutations PCR walking detection, ligase chain reaction, modification, method 675 greater efficiency, improved vectorettes-splinkerettes, method 1644 detection, PCR using Tli DNA polymerase 311 PDGF B-like protein Poly(A)-binding protein coding, novel c-sis mRNA 2815 synthesis, autoregulation 2198 Peach latent mosaic viroid Polyadenylation signal hammerhead self-cleavage 745 mammalian, cleavage site determinants 2614 PEP Polyamines and tagged PCR, mathematical analysis, whole genome amplification sequence specific DNA-protein interactions 1800 3034 Polyoma virus late RNAs PERT nuclear stability, governed by 5' splice site 4812 improved technique, thermal cycling 2339 Polypyrimidine sequences Phage display single-stranded, specific binding, NDP-kinase B 3858 immunoglobulin libraries, screening, ant-MI3 ELISA, whole phage PCR, Pre-mRNA maturation method 2563 line insertions, white gene, Drosophila melanogaster 4015 Phage Mu transposase Pre-rRNA att DNA binding domain, mutational analysis 3937 primary processing site, specific binding protein, identification 4963 Phage shock protein operon Primer cycle sequencing stress-induced, proteins, cis-acting elements, analysis 2030 dye-labelled, unpurified PCR products, templates, methods 2348 Phage titre Proliferating cel nuclear antigen measurement, fusion phage-substrate complexes dissociation constants, adenovirus ElA-responsive element, association, transcription factors, method 1531 RFXI/EF-C and ATF-I 3732 Phenylalanyl-tRNA synthetase Promoter DNA tRNAPhe transcripts, footprinting, novel interaction 4598 close contacts with ON protein, closed promoter complexes 351 Phosphodiester linkage Promoter recognition cleavage susceptibility 4753 transcription factors, archae 3837 Phosphorothioate oligodeoxynucleotides Promoter sequences binding, P-chirality independence 4239 aA-dependent, Bacillus subtilis, compilation, analysis 2351 Phosphorothioate oligonucleotides eukaryotic, analysis, CT-signal 1223 gram-scale purification, ion-exchange displacement chromatography aN protein 2292 close contacts with promoter DNA, closed promoter complexes 351 Phosphoryl migration Protein-DNA interactions chemical synthesis of RNA 3949 HSC82 heat shock gene promoter 1822 Photoactivated DNA nuclease low specificity, identification, multi-alphabet consensus algorithm 1434 binding modes, NMR 1576 soluble telosomes, Saccharomyces cerevisiae 1454 Photoadduct formation Protein-DNA recognition triplex-directed, psoralen-linked oligodeoxynucleotides, characteristics implications, base pair opening, spermine binding, gal operon fragment 4283 2065 Photooxidation Protein-peptide interactions d(TpG), riboflavin and methylene blue, isolation and characterization of analysis, yeast two-hybrid system, method 1152 products 3954 Protein-RNA interactions PHRI gene analysis, probe-modified RNA, 5-mercapto-UTP 1231 promoter elements, DNA damage response 4320 Protein binding interactions Picornavirus yeast 2,u m plasmid STB locus 995 internal ribosome entry segments, translation efficiency, and initiation Protein conjugates 3656 maleimide-mediated, nucleoside triphosphate gamma-S, intemucleotide PIGR gene phosphorothioate diester 2037 3' untranslated regions, mRNAs, discordant expression, variable triplet Protein kinase C repeat numbers 1098 queuine, tRNA modification, HeLa cells 2488 Plasma protein gene transfer RNA-guanine ribosyltransferase activation 2492 fat cell-free 2648 Proximal activation sequence Bombyx mori, transcription, body system AGGGTAGGGT, fission yeast, basal transcription activation 4296 Plasmid-chromosome recombination PRP8 protein 8-methoxypsoralen photoinduced, centromeric vector, Saccharomyces interaction with substrate RNA, yeast splicing 320 cerevisiae 1614 Pseudouridine residues Plasmid DNA retrieval SSU ribosomal RNA, Saccharomyces cerevisiae, mapping 3290 tissue culture cells, method 3073 PSM19035 plasmic Plasmid pPS10 a recombinase, binding, two sites 3181 replication protein, specific binding, HTH motif mediated 5048 Psoralen Plasmid templates derivative linked to oligonucleotides, solution structure 788 rapid preparation, no RNase treatment, method 3351 pUBIIO Platinum-DNA adducts replication initiator protein, autoregulation, plasmid copy number control detection, 32P-postlabelling 1300 1894 Subject index

Pulsed field gel electrophoresis Rho-independent terminators bacterial DNA, patients' sputa, method 722 actinophage XC31 early region 370 Purine-rich oligodeoxynucleotides Ribonuclease H competing self-structure triplex formation 1956 loss of active forms, Crithidia fasciculata RNHI gene, disruption 2526 Pyrimidine single strands Ribonucleotide reductase R2 mRNA targeting, triplex formation, binding, structural optimization 2937 3'-UTR, novel cis element, transforming growth factor-PI, mRNA R-loop formation stabilization, correlation 1461 sequence-specific, DNA scission 3524 Ribonucleotides R-loop stability 13C labelling, using acetate, preparation 3361 RNA structure and size 3516 Ribophorin I gene RAD16 cis-regulatory elements, functional characterization 313 DNA repair gene, regulation, Saccharomyces cerevisiae 1679 Ribosomal GTPase centre rad32 gene proteins, cooperative assembly 2396 Schizosaccharomyces pombe, cloning, characterization 383 Ribosomal protein genes rad78 yeast mutant Saccharomyces cerevisiae, transcription activation, T-rich sequence DNA repair, plasmid, genomic 3465 required 1475 Random amplified hybridization microsatellites Ribosomal protein Lii microsatellite-containing DNA clones, new class, method 3802 recognition, rRNA tertiary structure 3434 Rapid DNA preparation Ribosomal protein L16 2-D gel analysis, replication intermediates, method 3998 mitochondrial homologue, yeast nuclear gene, identification 3673 Rapid DNA sequencing Ribosomal protein S15 matrix-assisted laser desorption mass spectrometry, 7-deaza analogues, Escherichia coli, translational regulation, pseudoknot, molecular guanosine, adenosine, method 1570 dissection 18 Rat growth hormone gene Ribosomal protein S5 DNase I sensitivity analysis, chromatin, enhancer activity 2236 gene, cloning, characterization, Saccharomyces cerevisiae 4616 RBP-JK repression activity Ribosomal RNA mediated by co-repressor, antagonist EBNA2 transcription factor 4939 E.coli, nut region, interaction with mature 16S RNA 932 RD protein family enhancer binding protein, TIF-IB binding and transcription stimulation, spliceosomal complexes, detection by Ul 70K monoclonal antibody Acanthamoeba castellanii 4345 4081 small subunit, structural analysis, 'well-determined' regions 2791 rDNA Ribosome binding sites replication origin region, Tetrahymena thermophila, modular structural neural network models, Escherichia coli 1632 elements 1766 Ribozyme activity Tetrahymena thermophila, tandem repeats, high copy number group I introns, bidirectional effectors 1284 autonomous replicons, no effect on rRNA gene dosage 1561 Ribozymes Recoding accumulation, activity, RNA polymerase III promoter, tRNA-based use of versatile vectors, conservation of rules(yeast and mammalian) 2259 1557 synthesis, deprotection, analysis, purification 2677 RelB Rice-barley synteny Xenopus homolog, cDNA, molecular cloning 4664 saturation mapping, barley Rpgl region 2719 Rep proteins RNA geminivirus, origin cleavage and joining domain 910 cellular and viral, translational regulation, new gene family 2120 RepC initiator synthesis, deprotection, analysis, purification 2677 and iterons, interaction, RSFIOIO plasmid replication 3295 RNA-DNA complexes Repetitive element formation, immunoglobulin switch regions, transcription 5006 orphon spliced leader sequences, Angiostrongylus cantonensis 1030 RNA aptamers Replication factor C citrulline-and arginine-specific, base positions for binding 4769 Saccharomyces cerevisiae, fifth subunit, identification 4986 RNA binding Restriction endonucleases multiple domains, survey and summary 725 BsoFI, sensitivity, deoxycytidines 5'-methylation 4227 RNA binding selectivity SimI, non-palindromic sequence recognition 2571 alkylsulfide intemucleoside linkages, 2'-substituted 3'- Taq 521, novel, thermostable, GI1C(A or T)GC 4573 deoxyribonucleotides, structural basis 3967 type II, Sse 8647I, Streptomyces 742 RNA degradation Restriction enzyme EcoKI ribozyme-mediated, nuclei suspension 2223 UV crosslinking, bromodeoxyuridine-substituted DNA target sequence RNA editing 1177 substrates, products, potential intermediates, quantitation, developmental Reticulocyte lysate regulation 708 translation systems, endogenous DNA-binding proteins, depletion, rapid RNA elongation method 2076 differentiation stimulation, major stage-specific antigens, Trypanosoma Retinoic acid receptors brucei 1862 RARa and RXRa, interactions with Epstein-Barr virus BZLFI 7SL RNA gene transactivator 1729 Arabidopsis thaliana, transcription, U-snRNA gene-like promoter 1970 Retrotransposon 5S RNA gene Drosophila, complex transcription patterns, RNA polymerases II and III Xenopus TFIIIC, interaction 1551 4480 RNA genomes novel non-LTR, site-specific elements, miniexon arrays, Crithidia model for rearrangements 1870 fasciculata 2929 RNA helices Retroviral vectors purine-purine mismatches, protonated G.A pairs, nearest neighbour production, three plasmid expression system 628 effects 302 Reverse transcriptase RNA hypermutagenesis reaction readthrough, 2-5' linkage, 2'-thiophosphate 2811 substrate dependence, reverse transcriptase 2573 Reverse transcription RNA ligands efficient inhibition by antisense 2'-O-alkyl oligoribonucleotides 64 human nerve growth factor, high affinity 3198 Subject index

RNA ligase ribozyme RT-PCR method secondary structure, sequence optimization 3231 intact RNA detection, formalin-fixed paraffin-embedded tissue 3071 RNA molecules RuvAB-Holliday junction complexes circular, synthesis, method 3064 characterization, glycerol gradient segmentation 3621 RNA polymerase I S-adenosylmethionine elongation complex, pause signal, T3 box, Xenopus 2252 alters DNA contacts, Eco KI methyltransferase 967 RNA polymerase II biosynthesis, mutations, DNA methylation reduction 4818 basal transcription activity, regulation, cell cycle dependent 4050 Scanning mutagenesis pause positions, proximity to c-myc promoter 3373 proteins, nucleic acid binding sites, novel method 2579 RNA polymerase III Scanning probe microscopy dependence of LI promoter, transcription system 3704 G-wire(DNA nanostructure) 696 promoter and terminator elements, effect on AIu expression 1750 Selection marker system RNA polymerase III mediator complex arg3+, Schizosaccharomyces pombe, ura4+ application, method 1836 subunits, glucose repression 4421 Sequence data RNA polymerase III promoter consensus matches, detection, new tools 4878 tRNA-based, ribozymes, accumulation, activity 2259 Sequence variation RNA polynucleotides detection, PCR amplified fragments, electrophoresis method 4928 duplex DNA recognition 500 Sequencing RNA recognition automated, high-throughput, rapid purification, method 4930 probing, sequence-specific, bacteriophage MS2 coat protein 2512 Sequencing gels RNA secondary structure nucleotide inversions, dideoxy-mediated sequencing, terminal and substrate activity, potato nuclear extract 4246 deoxynucleotidyl transferase, methods 2341 RNA stacking Sex-lethal gene stabilization, pseudouridine 5020 transcription regulation, helix-loop-helix proteins 3449 RNA stemloop structures Short purine oligonucleotides molecular modeling technique, genetic algorithm 419 and SIV/HIV-2 vpx genes, high stability triple helices, targeted DNA RNA-binding proteins structure 3831 chloroplast, phosphorylation, affinity change 2506 Shotgun template-libraries gene family, cold-regulated, Anabaena variabilis M3 2161 fine-mapping, genomic DNA sequencing, efficient strategy 3842 RNAII Shuttle vectors IPTG-induced T7 RNA polymerase, Escherichia coli, non-functional, plasmid fragment insertion, method 5085 plasmid DNA replication 1691 Silencer element RNase 4 characterization, osteocalcin gene 5064 coding sequence, chromosomal localization, transcript identification, Silkworm TFIIIA somatic tissues 4290 requirements for transcription complex assembly, 5S RNA gene 1244 RNase H SIN3 2'-O-alkyl chimeric oligonucleotides, non-specific inhibition, antisense two promoter elements, INOI gene expression regulation 1964 oligomer design 3442 Sindbid virus RNase H-competent oligomers mRNA polynucleotide vector, heterologous gene expression, prolonged, antisense properties 1197 high level 1495 RNase P substrates Single-stranded DNA phosphate moieties, ribose moieties, identification 1845 containing (CTG)15, hairpin properties 1050 RNase protection assay dimeric intercalating dyes, interactions 1215 high throughput, method 3359 looped oligonucleotides, stable hybrid complexes 1170 RNP complex SIV/HIV-2 vpx genes novel, identification 2742 and short purine oligonucleotides, high stability triple helices, targeted Rpgl region DNA structure 3831 barley, saturation mapping, rice-barley synteny 2719 Ski proto-oncogene RPM) gene muscle-specific enhancer, activation 2988 yeast mitochondria transformation, mitochondrial RNAse P RNA 856 SNF2 protein family rpoH genes evolution, subfamilies 2715 isolation, sequence analysis, heat shock regulation 4383 SNF5 protein rpsl promoter S.cerevisiae, human homolog, interaction with potential helicase 1127 tissue-specific negative element, DNA binding protein, molecular snoRNA cloning 1165 U17, production, exonucleolytic processing 4670 16S rRNA snRNAs Escherichia coli, decoding region, mutagenesis 4234 three new, Saccharomyces cerevisiae, characterization 2548 Escherichia coli, impaired translational fidelity, structural changes 3563 Solid-phase synthesis Escherichia coli, mutation, spectinomycin resistance 464 nucleopeptide, adenovirus-2 nucleoprotein, convergent strategy 4151 23S rRNA Sonic hedgehog role of domain IV, subunit-subunit interactions, peptidyl transferase Xenopus laevis, potential morphogen, embryogenesis, metamorphosis centre 1512 2555 rRNA encoding chromosome Southern and Northern blot fixing frequently rearranged, structure, Giardia lamblia 3310 microwave oven, method 879 5S rRNA gene Sox-18 transcription factor internal control region, in vivo analysis, Saccharomyces cerevisiae 634 DNA-binding properties, trans-activation 2626 Sox6 gene rRNA tertiary structure Sry-related, expression, mouse 3365 recognition, ribosomal protein Ll 1, thiostrepton 3434 Spl RSF1010 plasmid and NF-Y glutamine-rich activators, cdc25c transcription cell-cycle replication, RepC initiator and iterons, interaction 3295 regulation 3822 RSV leader RNA and USF, transcription factors, DNA binding, regulatory effects 2229 uORFs, efficient translation, translational regulation, viral RNA Specific DNA excision packaging 861 via site-specific recombination, integrated retroviral vectors 4451 Subject index

Spectinomycin Taq DNA polymerase resistance, 16S rRNA mutation, Escherichia coli 464 rapid purification, freezing, high temperature thawing, method 4518 Spectroscopic studies Target motif intramolecular triple helices, chimeric DNA-RNA, 29mer RNA 1722 hammerhead ribozymes, cleavage rates, comparative analysis 1192 Splinkerettes TATA binding protein improved vectorettes, greater efficiency PCR walking, method 1644 STDI(MSN3), interaction 3174 SSCP primer design Sulfolobus shibatae, cloning and functional analysis 1775 single-strand DNA structure, DNA folding program 2287 TBP binding ssDNA inhibition, distamycin A, tallimustine 1657 from phagemids, production, helper phage-infected competent cells, Telomerase RNA method 535 ciliate, structural features 1091 Sse83871 Telomere protein activity, methylation, base cutter, genome analysis 2367 Oxytricha, phosphorylation, cell cycle regulation 1887 STAT genes Telomeres genomic structure, multiple exons in coincident sites 459 Theileria parva, 3 Mb chromosome, characterization 1942 STAT protein complexes Termination codons differential activation, sequence preferences, transcriptional induction 5' context, Escherichia coli, human, similarities 4712 properties 3283 Tetracycline STD1(MSN3) gene activities, co-regulation, bidirectional promoter, method 3605 interaction, TATA-binding protein, SUC2 gene, transcription 3174 TFE3 (bHLHZIP) protein Stem-loop binding protein activation domains, transcription activation 3865 histone mRNA 3' end, stem and flanking sequences, critical TFIIIA binding site determinants 654 5S RNA gene, Xenopus, zinc(II) ions, selective interaction 2464 Stereodifferentiation TFIIIC P-chirality, effect on bacterial RNase H activity 5000 Xenopus, 5S RNA gene, interaction 1551 Steric-blocking oligomers TGA factors antisense properties 1197 in nuclear ASF-1 activity, differential representation, binding site Streptomycete promoters requirements 3778 identification, classification, computer assisted 3696 TGF-1 regulated gene Stringently regulated genes identification, zinc finger protein, osteoblasts 4907 expression, autocatalytic conditional mammalian system, method 307 P-Thalassemia Substrate RNA ,B-globin gene nonsense mutations, nuclear degradation, implications for interaction with PRP8 protein, yeast splicing 320 heterozygotes 413 Subtracted cDNA libraries TheUeria parva generation, phage lambda vectors, improved method 3355 3 Mb chromosome, telomeres, characterization 1942 generation of, method 2565 Thiostrepton Subtractive hybridization recognition, rRNA tertiary structure 3434 a kinetic model 176 thra terminator Sulfurizing reagents Escherichia coli, transcription termination, spinach chloroplast RNA new, oligodeoxyribonucleotide phosphorothioate analogues, preparation polymerase 4690 4029 D- and L-thymidine 5'-triphosphate Sulphur mustards substrate, stereospecific recognition, DNA polymerases, HIV-reverse binding inhibition, AP2 transcription factor 4378 transcriptase, calf thymus terminal transferase 2840 Supercoiled templates Thymidine C5-hydrate in vitro transcripts, detecting, mapping, rapid method 4734 ring fragmentation product, effects, phosphodiesterases, Klenow Surface plasmon resonance fragment 4642 E.coli methionine repressor-operator complex, effect of co-repressor Thymidylate synthase 211 and thymidylate synthase RNA, specific interaction, Ecoli 869 Surface protein mRNA Thymidylate synthase gene Tetrahymena, temperature regulated stability 942 expression regulation, growth-stimulated cells, mouse 4649 Suvar(3)7 locus Thyroid hormone receptor DNA bending, half site spacing, RXR 811 Drosophila, position-effect variegation, deduced protein 796 TIMP-1 gene Synthetic mini-genes interleukin 6/oncostatin M duplex DNA, phosphorothioate modified, stability, functional response element, identification 5041 effectiveness 4134 Topoisomerase II DNA cleavage Synthetic oligonucleotides amonafide stimulation, sequence-specificity 223 n-I product, sequence identity 1841 TOTO binding method homodimeric thiazole orange dye, bis-intercalation, site-selective, DNA pool preparation, 3603 oligonucleotides 753 sequencing, homopolymeric tailing, method 1271 Transcription factor IIB T cell human autoantibodies, identification 2770 apoptosis, mRNA deregulated expression 4857 Transcription factors T3 box HSV a gene promoters, interactions, sensory neurons 4978 pause signal, RNA polymerase I elongation complex, Xenopus 2252 promoter recognition, archae 3837 T4 endonuclease V SPI and USF, DNA binding, regulatory effects, APP promoter (rat) W128S mutant, decreased activity 3764 2229 Tagged PCR Transcription initiation factor and PEP, mathematical analysis, whole genome amplification 3034 TFIIF, cDNA, molecular cloning 1882 Tall minigene Transcriptional activators cassette exons, splicing, relative affinities 3585 two binding sites, c-sis/PDGF B gene promoter 1119 Tallimustine Transcriptional repressor antitumor drug(distamycin derivative), sequence-specific adenine produced by alternative translation, trinucleotide repeat 138 alkylation 81 Transferrin gene TBP binding and basal in vitro transcription inhibition 1657 human, neuronal cells, transcription 2206 Subject index

Transformation of E.coli Ul snRNP large DNA molecules, electroporation 1990 ASF/SF2, interaction, 5' splice site recognition, required elements, Transient expression characterization 3260 in insect cells, recombinant baculovirus, method 188 Ul snRNP-specific protein C Translational reinitiation homodimerization 4864 GCN4 mRNA, sequence requirements 3981 U2afl-rsl (SP2) gene Transplatin allele-specific methylation, expression 36 reaction with native DNA, clinical inefficiency 2381 U7 snRNPs Transposon Tn3 assembly, nuclear import, function 3141 insertion site specificity 507 U14 small nucleolar RNAs Transrepressor P11 location, processed during early oogenesis 4844 (of retrotransposon 1731), cloning, characterization 5073 UBF Transverse temperature gradient-SSCP RNA polymerase I transcription factor, HMG box 4, species specificity cold-SSCP mutation detection, temperature optimization, method 4224 4583 TRAP modifications UGA4 gene reliability, linearity, sensitivity 3794 inhibition by UASGATA, regulatory systems, Saccharomyces cerevisiae Trinucleotide repeats 558 alternative translation produces a transcriptional repressor 138 Ultrasensitive hybridization analysis d(GTC)15, hairpin conformation 2706 fluorescence correlation spectroscopy 1795 recognition, DNA binding proteins, single-stranded, mouse brain 2654 Uni chromosome Triple helices Chlamydomonas, histone genes, nucleosome structure 3756 varied backbone structure, relative stabilities, chimeric circular Universal bases oligonucleotide probes 1157 3-nitropyrrole and 5-nitroindole, primers, DNA sequencing, PCR 2361 Triple helix DNA Urokinase-type plasminogen activator(uPA) histone-DNA interactions, nucleosome barrier 2184 suppressed synthesis, NF-KB-Rel A inhibition, no effect on PAI-I 3887 Triple stranded complex USF NMR characterization, homopurine and homopyrimidine DNA 4116 and SPI, transcription factors, DNA binding, regulatory effects 2229 Triplex formation UV photoproducts competing self-structure, purine-rich, oligodeoxynucleotides 1956 in DNA, cleavage, novel reagents 1664 phosphodiester, phosphorothioate oligodeoxyribonucleotides, polyamine T-T pyrimidine(6-4)pyrimidinone, mutagenic, lower in yeast 1919 effects 2320 V(D)J recombination single strand targeted, guanine quadruplexes, destabilization 1060 efficiency, altered by coding sequence composition flanking signal targeted single strand, abasic linkers 4510 elements 1060 Triplex inhibition Vaccinia virus early transcription factor potassium mediated, overcome 1936 DNA binding domain, extended helicase-like motif 1590 Triplex-bridge formation Varicella-zoster virus DNA sequence protection 452 immediate-early protein IE62, mutational analysis 1341 tRNA Vector insertion central fold, ribosomal neighbourhood, cross-links 4635 embryonic stem cells, gene conversion 2058 cleavage, imidazole, spermine imidazole constructs 3161 virD2 3' truncated forms, conversion to RNA cutters, four-base-recognition Agrobacterium tumefaciens, conserved motif, mutational analysis 4087 3642 Virus-parasite association tRNA-tufB operon Leishmania and Leishmania RNA virus, phylogenetic analysis 2300 genetic and molecular analysis, myxobacterium-Stigmatella aurantiaca Vitamin D receptor 1737 multiple dimerization interfaces 606 tRNA genes Vitamin D3 transcribed from plastid-like DNA, Plasmodium falciparum 4329 signal transduction, inhibition, calreticulin 3268 tRNA modification white gene queuine, HeLa cells, protein kinase C 2488 Drosophila melanogaster, line insertions, pre-mRNA maturation 4015 tRNAArg (AGG) gene Whole genome amplification site-specific integration of actinophage RP3, Streptomyces rimosus 58 mathematical analysis, PEP and tagged PCR 3034 tRNAL' Wilms' tumour suppressor protein (WT1) identity elements, tRNASer conversion, leucine acceptor 3633 high affinity binding sites 277 tRNALeU3 gene structure yeast, transcription start site, mutational analysis 2914 X-ray crystal tRNALYs3 dimethylene sulfone-bridged ribonucleotide dimer, single-stranded 2427 XDH/XO basal promoter cleavage, in cells expressing bacterial anticodon nuclease 1744 tRNAPhe transcripts transcription, C/EBP binding sites, multiple initiators 3132 footprinting, phenylalanyl-tRNA synthetase, novel interaction 4598 Xenopus oocytes tRNAPr° promoter control of translation 405 molecular recognition, Ecoli proline tRNA synthetase 165 XmaI endonuclease tRNAThr sequence-specific recognition, DNA determinants 3571 identity elements, threonyl-tRNA synthetase, Saccharomyces cerevisiae XRCC-1-DNA ligase Ill complex 2831 in vitro, characterization 4836 TIberous sclerosis gene (Tsc2) YAC arms exon-intron organization, alternative splicing, cDNA structure 2608 insertion of unique sites, rapid physical analysis, method 4012 Tlwo-hybrid assay YAC clones new version, protein-protein interactions, methods 876 integrative modification, 96-well microplate, method 1830 Two-hybrid plasmids YAC DNA identification, yeast transformants pool, method 4222 arrayed preparation, PFGE analysis, method 4526 Tyrosine minigene co-injection M13 libraries, construction, analysis 670 marker, genetic manipulations, transgenic mice 4551 preparation, labelling, FISH analysis, method 720 Ul 70K monoclonal antibody YAC insert sequences RD protein family, spliceosomal complexes 4081 isolation, representational difference analysis, method 4127 Subject index

YACs compositional analysis, rapid procedure, methods 4014 construction of specific cosmids, homologous recombination, method 4006 large DNA fragments, recombination-based cloning, new vector 4850 mega insert, screening arrayed cosmid libraries 1085 unequal homologous recombination, human DNA 3691 Yeast 2pmm plasmid STB locus, protein binding interactions 995 Yeast chromosome VIII centromere DNA, functional selection 922 Yeast clone screening PCR, DNA preparation, method 4924 Yeast genome precise alterations, recyclable selectable marker, method 3079 Yeast transcription factor TFIIH Tfbl and Ssll subunits, interaction, DNA repair activity 767 YY1 adenovirus EIA, functional interactions 925 YY1 binding sites high affinity, core type identification, potential binding site distribution, ,-globin cluster 4353 YY1 transcriptional activator/repressor DNA binding sites 4457 ZEMa MADS box genes, alternative splicing 2168 ZNF80 locus characterization, genomic mapping 2823

Author index

Aasland,R. 3168 Aoki,T. 1098 Balakin,A.G. 2548 Belogurov,A.A. 785 AB,G. 2389 Aoyagi,M. 2080 Balciunas,D. 4421 Belyavsky,A.V. 2954 Abdul-Manan,N. 725 Arai,Y. 36 Balis,F.M. 2872 Benachenhou,N. 4312 Abdurashitov,M.A. 2571 Arakali,A.V. 1810 Ballard,M.J. 4900 Benard,L. 18 Abendroth,F.D. 2770 Arbuthnot,P. 4518 Balsari,A. 4603 Benard,M. 1447 Aboud,M. 2621 Arcangeli,L. 2269 Bambeck,G.S. 4224 Benbow,R.M. 1766 Abrams,E.S. 2775 Arents,G. 2685 Bang,D.D. 1679 Bender,L.B. 1244 Abravaya,K. 675 Arkhipova,I.R. 4480 Bannon,G.A. 942 Bendich,A.J. 3999 Abu-Daya,A. 3385 Arkov,A.L. 4712 Bannwarth,W. 4827 Bendiscioli,A. 2840 Achsel,T. 3633 Amaud,D. 4011 Barak,Y. 2584 Benimetskaya,L. 4239 Adams,C.C. 1822 Arnheim,N. 3034 Baralle,F.E. 238 Benner,S.A. 2427 Adams,C.J. 2512 Arrebola,R. 2856 Barawkar,D.A. 159 Bennett,D. 154 Adams,M.J. 4520 Arst,H.N.Jr 3069 Barilla,K.C. 277 Bennett,R.A.O. 5027 Adamski,F.M. 1487 Artandi,S. 1800,4371 Baron,U. 3605,5080 Benore-Parsons,M. 4926 Agol,V.I. 1870 Artandi,S.E. 3865 Barrett,M.T. 3488 Berberof,M. 1862 Agrawal,S. 1068,1271,1841, Asahara,H. 389 Barrett,N.L. 4812 Berg,C.M. 117 3578,4510 Asai,T. 3119 Barry,C. 1729 Berg,D.E. 117 Aiba,H. 599 Asakura,H. 3771 Barry,J.D. 3103 Bergemann,J. 4451 Aidinis,V. 2742 Ash,J. 4649 Bartel,D.P. 2811,3231,4220 Berger,I. 4488 Aizawa,A. 2236 Ashford,S.R. 2074 Bartilson,M. 1551 Bergmann,S. 4023 Akerman,B. 2413 Ashworth,A. 3365,4005 Bartlett,R. 203 Bergot,B.J. 2292,2754 Akiyama,Y. 419 Asiedu,C.K. 3026 Barzilay,G. 1544 Bergson,C. 3481 Akusjarvi,G. 588 Aslanzadeh,J. 3788 Baskin,D. 4930 Berkhout,B. 1319 Alderfer,J.L. 1810 Assar,H. 1948 Bates,D.B. 3119 Bernardi,G. 4013 Allain,F.H.-T. 341 Auer,H. 3449 Bates,P.J. 3627,4283 Bemier,V. 2856 Allegra,C.J. 869 Auffray,C. 1642 Batista,F.D. 4805 Berressem,R. 3465 Allen,P. 3198 Aussourd,C. 2381 Battiloro,E. 879 Bertioli,D.J. 4520 Alonso,A. 5034 Austin,S. 351 Baudoux,L. 1341 Bertoncini,C.R.A. 2995 Alonso,D. 620 Avitahl,N. 3865,4371 Bauer-Hofmann,R. 5034 Berzal-Herranz,A. 849 Alonso,J.C. 1894,3181 Avizonis,D.Z. 1260 Baum,N. 1901 Beskin,A.D. 2881 Althaus,F.R. 1396 Avner,P. 4011 Baumann,P. 1775 Best-Belpomme,M. 5073 Altmann,S. 4827 Axelrod,N. 4893 Baumstark,T. 4246,4524 Besterman,J.M. 1597 Amagasa,T. 2080 Ayers,D.F. 2259 Baxevanis,A.D. 1019,1604, Bettany,A.J.E. 4190 Amaldi,F. 4670 Azhayev,A. 1170,4255 2685 Bhagwat,A.S. 29 Amara,F.M. 1461 Azhayeva,E. 1170,4255 Beard,W.A. 1597 Bhaumik,S.R. 4116 Ambulos,N.P.Jr 442 Azorin,F. 2464 Beaudry,D. 745,3064 Biamonti,G. 962 Amir-Aslani,A. 3850 Azum,M.-C. 2669 Beck,J. 4954 Bianchi,N. 1671 Amitsur,M. 1744 Baas,P.D. 248 Beck,S. 1367 Bidou,L. 1557 Anderson,L. 4926 Babb,B. 3696 Becker,P.B. 2479 Bigey,P. 3894 Anderson,R.C. 1279 Babiss,L.E. 1197 Beggs,J.D. 320,4616 Billeter,M. 4827 Andre,B. 550,558 Babon,J.J. 5082 Behe,M.J. 689 Binkley,J. 3198 Andreadis,A. 3585 Bachellerie,J.-P. 2669 Behr,J.-P. 3161 Bird,A.P. 203 Andrews,M.T. 4844 Bachhawat,A.K. 4932 Beier,H. 4591 Birke,S. 2314 Andrews,W.H. 3244 Baeuerle,P.A. 1443 Beigelman,L. 3989,4434 Birren,B. 1990 Angeletti,B. 879 Bagdasarian,M. 3295 Beinhauer,J.D. 922 Birschtein,B.K. 975 Angiolillo,A. 1359 Bagga,P.S. 1625 Beldjord,C. 3419 Bisant,D. 1632 ann,J.A. 1140 Bailly,C. 885 Belichenko,O.A. 2571 Bisanz-Seyer,C. 1165 Ansari,P. 5027 Bailly,J.-L. 3656 Belikov,S. 310 Bisceglia,L. 4134 Antoniou,M. 3473 Bakalkin,G. 362 Bell,S.D. 3103 Bishop,R.P. 1942 Antoniw,J.F. 4520 Bakin,A. 3290 Bellorini,M. 1657,4565 Bisi,J.E. 1197 Author index

Christensen,L.M. 2754 Cutts,S.M. 42,2450 Debbie,P. 3944 Dreyling,M.H. 1085 Christodoulou,C. 2348 Cvekl,A. 442 Deeley,R.G. 2137,3252 Dryden,D.T.F. 1177 Chu,E. 869 Czamy,A. 3678 Defechereux,P. 1341 Du,C. 1766 Chu,W.-M. 1758 D'Amato,M. 2078 Degtyarev,S.Kh. 2571 Dubaova,M. 3252 Chu,W.M. 1750 D'Ambrosio,E. 879,1333 Deininger,P.L. 2245 DuBois,M.L. 1279 Chuang,S.-E. 1641 D'Incalci,M. 81,1657 Deissler,H. 4227 DuBois,S. 3648 Church,G.M. 4922 Dafni,N. 307 Delius,H. 3842 Dueholm,K.L. 217 Ciafre S.A. 4134 Dahl,O. 3349 Delver,E.P. 785 Dujon,B. 4011 Ciana,P. 2328 Dahlberg,A.E. 3563,4234 Demeret,C. 4777 Dunbar,J.C. 3571 Ciarrocchi,G. 962 Dalbies,R. 949,2381 Demers,D.B. 3050 Dunford,R.P. 2724 Cifarelli,R.A. 3802 Dale,E. 485 Demple,B. 5027 Dunn,T.L. 2626 Civas,A. 5055 Dalgleish,G. 1354 Denny,P. 3365 Durland,R.H. 647 Clark,A.G. 3882 Dalluge,J.J. 2641 DePaulo,J. 767 Durosay,P. 3501 Clark,M.P. 3132 Damay,P. 861 Deppert,W. 4023 Duroux,I. 3411 Clarke,J.C. 1948 Damha,M.J. 3967 Desai,A.B. 1239 Dyer,K.D. 4290 Cleard,F. 796 Danchin,A. 3554 Deschavanne,P. 1350 Dyer,R.B. 3345 Clegg,R.M. 3363 Dangel,A.W. 2120 DeStefano,J.J. 3901 Dykes,C.W. 2348 Codani-Simonart,S. 5073 Danielian,P.S. 1686 Deuter,R. 3800 Dynan,W.S. 2770 Cohen,S.N. 701 Daniels,D.L. 2105 Devignes,M.-D. 1642 Dyson,M.R. 1531 Coleman,M.S. 2041 Daniels,G.A. 5006 Devon,R.S. 1644 E,Y. 3310,4893 Coley,H.M. 81 Danna,K.J. 4738 Devreese,B. 51 Ebbert,R. 230 Colnaghi,M.I. 4603 Dar,M.E. 3224 Di Cristofano,A. 2823 Ebel,T.T. 2076 Colonna,F. 2840 Darlington,G.J. 4726 Di Lacio,L.C. 1273 Eberhardt,N.L. 3607 Comai,L. 3999 Darlix,J.-L. 2434 Diaz-Orejas,R. 5048 Ebersole,R.C. 522 Conley,D.L. 701 Darnell,J.E.Jr 459 Diekmann,S. 3363 Echeverria,M. 4963 Connor,F. 3365 Darracq,N. 5055 Dill,J. 1050,2706,4055 Eckstein,F. 2223 Conrad,F. 1845 Das,A. 4087 Dimaculangan,D.D. 811 Eder,C. 1704 Conry,R.M. 1495 Das,A.T. 1319 DiRenzo,A. 2677 Efimov,V.A. 4029 Constantinesco,F. 4312 Das,G. 313 Dirheimer,G. 779 Efremov,D.G. 4805 Cook,A.F. 285,2025 Datsugue,B. 4015 Diriong,S. 4415 Eggert,M. 4785 Cook,P.D. 2019 Datta,A.K. 4530 Dirks,R.P.H. 1119,2815 Egholm,M. 217,3050 Cooper,C. 4371 Dautant,A. 1710 Dissing,M. 467 Egli,M. 2427 Cooper,M. 4616 Davidson,L.A. 3071 Divoky,V. 4736 Ehlert,F. 3822 Coornaert,D. 558 Davies,A. 720 Dobbs,D.L. 1766 Ehresmann,B. 18 Copertino,D.W. 4745 Davies,C.J. 507 Dodou,E. 4267 Ehresmann,C. 18 Costa,R.H. 1184 Davis,D.R. 5020 Doerfler,W. 4227 Ehrlich,M. 3026 Cote,V. 2519 Davis,E.L. 3788 Doherty,A.J. 2074 Eick,D. 72,3373 Cotter,R.J. 3126 Davis,J.P. 4471 Doly,J. 5055 Eickbush,T.H. 4628 Cotterill,S. 4443 Davis,R. 4337 Domdey,H. 1133 Eisen,J.A. 2715 Cotton,R.G.H. 5082 Day,I.N.M. 2404 Dominy,P.J. 176 Eisenstein,R.S. 4190 Coull,J. 217 de Boer,A.J. 3214 Dong,B. 3989 Ekland,E.H. 3231 Couture,L. 2259 de Boer,E. 3473 Donze,O. 861 Elliott,L.F. 2569 Cox,M. 3189 De Boer,S.H. 2567 Dooley,S. 2300 Elliott,M.S. 2492 Crane-Robinson,C. 4262 De Bruyn,A. 51 Doring,T. 4635 Ellis,P.D. 3962 Creanor,J. 4761 de Costa,L.T. 4127 Dorner,M. 3380 Elroy-Stein,O. 1744 Crystal,R.G. 293 De Isabella,P. 223 Dosanjh,H.S. 3627 Engeland,K. 3822 Cui,T. 377 de Jong,A. 2815 Dotan,I. 307 Engelbrecht,J. 1223 Cuin,K.A. 1854 de Jong,P.J. 4127 Douthwaite,S. 2396 Engelhom,M. 2959 Cullinane,C. 42 de Melo Neto,O.P. 2198 Douville,P. 4978 Engels,J.W. 3465 Cummins,L.L. 2019 De Paolis,A. 2914 Dowhan,D.H. 2626 Engert,J.C. 2988 Curiel,D.T. 1495 De Sario,A. 4013 Downes,M. 1311 Englund,P.T. 4426 Curran,J.F. 683,4104 DeAngelis,M.M. 4742 Drake,M.E. 4015 Enlow,B.E. 3244 Curry,E.T. 3050 Deaven,L. 1838 Draper,D.E. 302,3426 Ennis,H.L. 3018 Author index

Enomoto,T. 2014 Fox,G.E. 4303 Geigl,E.M. 4013 Goringer,H.U. 3093 Enssle,J. 413 Fox,K.R. 3385 Geiselmann,J. 2959 Gossen,M. 3605 Erbe,J.L. 2472 Franqois,J.-C. 1956,4042 Geiss,G.K. 4345 Gothelf,Y. 3539 Eriani,G. 779 Frauendorf,A. 1204 Genq,B. 4227 Gottlieb,P.A. 1502 Eriotou,P. 2492 Frech,K. 4878 Genin,P. 5055 Gould,K.G. 2641 Eritja,R. 3648 Freier,S.M. 2019,3003 Georgel,P. 1140 Gouyette,C. 1722 Erkine,A.M. 634,1822 Fremaux,C. 1737 Georgiev,O. 736,2277,4978 Govil,G. 4116 Essigmann,J.M. 4066 Fresco,J.R. 2692 Gerena,L. 844 Grace,M.B. 4224 Evan,G.I. 1686 Freundlieb,S. 3605 Gerlach,W.L. 2909 Graeff,H. 3887 Evans,D.H. 4620 Frey,M. 3347 Germaschewski,V. 1531 Graeve,L. 5041 Faaland,C.A. 3594 Fried,M. 901 Gerschenson,M. 88 Gramatikoff,K. 736 Fagan,P.A. 1567 Fried,M.G. 2346 Gerstner,J.A. 2292 Grandas,A. 4151 Fairhead,C. 4011 Frijters,A. 4407 Ghosh,R. 4934 Grant,C.E. 2137 Falaschi,A. 2457 Froehler,B.C. 1197 Giacomini,P. 1671 Grant,C.M. 3980 Famulok,M. 4769 Frommer,W.B. 3355 Giannini,S.L. 975 Graves,D.E. 1252 Fantes,P.A. 4761 Fruscoloni,P. 2914 Gibbs,P.E.M. 1919 Gray,P.J. 3508,4378 Farace,M.G. 4134 Fu,D. 3126 Giege,R. 3161,4598 Green,J.A. 954 Farkas,T. 467 Fuciarelli,A.F. 515 Gilbert,D.M. 3997 Green,L. 3198 Farmer,A.A. 4210 Fujita,N. 827 Giles,R.V. 954 Greenberg,M.M. 4642 Favreau,M.R. 4745 Funk,W.D. 3244 Gilgen,M. 4001 Gregersen,N. 256 Fazio,R.C. 3600 Futscher,B.W. 4740 Gilmour,D.S. 3327 Gregory,S.T. 4234 Fazio,V.M. 4134 Gabriel,A. 2929 Giorgi,D. 4415 Grenson,M. 550 Fearon,K.L. 2754 Gabriel,K. 58 Girard,J.-P. 1912 Griffioen,G. 1475 Fehse,B. 4451 Gallitelli,M. 3802 Girard,M. 3656 Griffith,M.C. 3003 Felden,B. 3161 Gallo,M.A. 3594 Glazer,A.N. 1215 Griffiths,J.C. 628 Feng,J. 3244 Gallois,B. 1710 Gleiberman,A.S. 1098 Griffor,M.C. 3995 Ferbeyre,G. 4092 Galman,M. 2770 Glick,G.D. 2153 Grimm,E. 4518 Feren,A. 1098 Galvin,K.M. 925 Gmeiner,W.H. 3916 Grimm,S. 2677 Feriotto,G. 1671 Gambari,R. 1671 Gmyl,A.P. 1870 Gromova,E.S. 2192 Fermandjian,S. 3831,3850 Ganesh,K.N. 159 Gobright,E.I. 1942 Grondahl,B. 3837 Fernandes,M. 4799 Gangloff,J. 779 Goda,S.K. 3357 Gronenborn,B. 535,910 Femadndez,A. 1327 Ganguly,K. 3018 Godard,G. 3411 Groom,K.R. 856 Ferris,R. 4320 Gannett,P. 713 Godde,J.S. 4557 Grosjean,H. 4312 Fichant,G.A. 2900 Ganousis,L. 2259 Godovikova,T.S. 4400 Gross,B.L. 4104 Fields,S. 1152 Ganster,R.W. 3174 Gohl,H.P. 3837 Gross,C. 3822 Filipowicz,W. 1970 Gao,H. 285,2025 Gold,B. 713 Gross,D.S. 1822 Filipski,J. 1350 Gao,M. 1822 Gold,L. 3198 Gross,H.J. 3633 Finnegan,D.J. 1354 Gao,X. 4303 Goldgaber,D. 2734 Gross,I. 1140 Fiorenza,M.T. 467 Garbesi,A. 2840 Goldman,D. 2287 GroB,T. 4296 Fischer,A. 1901 Garcia,J.A. 1327 Goldspink,G. 2636 Grossman,A. 2127 Fischer,D.R. 1419 Garcia de Viedma,D. 5048 Goldstein,D.B. 3882 Grosveld,F. 3473 Fjellstrom,R.G. 2569 Garcia-Blanco,M.A. 3260 Gonqalves,P.M. 1475 Grummt,I. 2593 Fleig,U. 922 Garestier,T. 1956,4042 Gong,D.-W. 1882 Gruss,C. 773 Flugel,R.M. 2621 Garrett,R.A. 1512 Gonzalez,C. 2677 Gryaznov,S. 2344 Flusberg,D. 2584 Gary,S.L. 4986 Gonzalez-Pacanowska,D. Gryaznov,S.M. 2661 Focher,F. 962,2840 Gasparini,P. 4134 2856 Gu,X. 4734 Fodor,E. 2641 Gassmann,M. 4542 Goodman,M. 4353 Gualberto,J.M. 1970 Fodor,E.J. 1098 Gaston,K. 901 Goodman,S.T.S. 2512 Guan,X. 4127 Foiret,D. 4312 Gathy,K.N. 2041 Gopal,J. 29 Guerrini,L. 2328,3887 Folta-Stogniew,E. 1984 Gatsios,P. 5041 Gopal-Srivastava,R. 442 Guga,P. 4239 Forbes,S. 1354 Gaur,R.K. 1845 Goping,I.S. 1717 Guialis,A. 2742 Ford,L.P. 1625 Gay,N.J. 3111 Gordon,D. 4900 Guieysse-Peugeot,A.-L. 4044 Foumier,M.J. 2548 Geacintov,N.E. 2314 Gorecki,D.C. 2636 Guimaraes,M.J. 1832 Author index

Guinosso,C.J. 2019 Hata,K. 3704 Hickson,I.D. 1544 Hurt,M.M. 3083 Guittet,E. 1722 Hatada,I. 36 Hildebrandt,M. 3858 Husain,I. 1597 Gulli,M.-P. 1912 Hatahet,Z. 1089 Hill,F. 2361 Hutchison,C.A.,III 803 Gultyaev,A.P. 3718 Hatfield Truby,T.M. 522 Hillier,L. 670 Hutchison,C.A.III 507 Gumport,R.I. 4690 Hattori,M. 3704 Himeno,H. 389 Huynh-Dinh,T. 1722 Gumucio,D.L. 4353 Haupt,Y. 2584 Hines,J.C. 2526 Hwa,K. 4426 Gunkel,N. 405 Hawkins,M.E. 2872 Hinnebusch,A.G. 3980 Hyde,E.I. 1518 Gupta,A. 729 Hawkins,T.L. 4742 Hino,O. 2608 Hyde-DeRuyscher,R.P. 4457 Guschlbauer,W. 3648 Haworth,I.S 2706 Hiom,K. 3621 Hyrup,B. 2427 Gut,I.G. 1367 Haworth,I.S. 1050 Hirai,H. 2762 Ibba,M. 2886 Guzaev,A. 4255,11790 Haxton,K.J. 4642 Hirakawa,K. 2080 Ide,H. 123 Haberhausen,G. 1441 Hay,J.G. 293 Hirayama,Y. 2608 Ignatovich,O. 4616 Hackl,W. 3141 Hay,R.T. 3393 Hjalt,T.A.H. 571,580 Ikeda,H. 357 Hadfield,C. 995 Haynes,S.R. 835 Ho,P.S. 1977 Ilagan,J.G. 442 Haeberli,P. 3989,4434 He,B. 1231 Hofelein,C. 4001 Imagawa,M. 606 Hagerman,P.J. 3363 He,M. 4009 Hofferer,L. 1396 Imai,T. 2762 Hagmann,M. 4978 Heard,D.J. 1970 Hoffman,D.C. 1279 Imam,A. 3473 Halaban,R. 154 Heard,E. 4011 Hoffman,D.W. 3361,4058 Ingham,C.J. 370 Hald,M. 4576 Hecht,S.M. 3949 Hoffman,P.W. 2229 Inoue,H. 2893 Hale,T.K. 663 Hegemann,J.H. 922 Hogers,R. 4407 Inoue,J. 4664 Hall,J.L. 3756 Heidenreich,O. 2223,2344 Hoheisel,J.D. 3842 Inoue,K. 3441 Hall,L.M. 2472 Hein,C. 558 Holberton,D.V. 2945 Inze,D. 3359 Halleen,J. 244 Heinrich,J. 1468 Holland,J.A. 3361 Ishihama,A. 819,827 Hallick,R.B. 4745 Heinrich,P.C. 5041 Honda,K. 123 Ishikawa,H. 2893 Halmer,L. 773 Heiser,W.C. 2803 Honda,Y. 3295 Ishino,Y. 742 Hamada,H. 2080 Helene,C. 1956,3411,4042 Hopfer,S.M. 3788 Isono,K. 595 Hamaguchi,J.R. 1887 Helmann,J.D. 2351 Horikoshi,M. 1882,3351 Itoh,T. 4196 Hamilton,T.B. 277 Hemmerich,P. 195 Homes,M. 4407 Ivanova,N.B. 2954 Hamlin,J.L. 261 Henderson,A. 4371 Horsfield,J.A. 1487 Izumi,S. 2648 Hamon,M. 4009 Henderson,E. 696 Horsford,J. 1948,3268 Jackson,S.P. 1775 Hanaoka,F. 2893 Henderson,G.B. 3726 Horton,J.K. 3810 Jacobs,E. 3079 Hanawalt,P.C. 1782,2715 Hendricks-Taylor,L.R. Hoshijima,K. 3441 Jacobsen,J.P. 753,4576 Hancock,D.C. 1686 4726 Hosking,B.M. 2626 Jacobson,A.B. 2791 Hanna,M.M. 1231 Hendrickson,E.R. 522 Hottiger,M. 736 Jaffray,E. 3393 Hanne,A. 1845 Hendrix,C. 51 Hou,G. 3310 Jaklevic,J.M. 982 Hanni,C. 881 Hendry,P. 3922,3928 Hou,Z. 1766 Jakubowski,H. 4608 Hansen,L.F. 753 Hendy,G.N. 3268 Houmiel,K.L. 88 Jamison,S.F. 3260 Hanvey,J.C. 1197 Henriques,J.A.P. 1614 Hovinen,J. 1170 Jamry,I. 117 Hardin,J.A. 2770 Henry,S.A. 1964 Hoyhtya,M. 244 Jane,S. 4738 Harrington,C. 1003 Henry,Y. 2669 Hsu,E.-L. 4683 Janjic,N. 4471 Harris,S.A. 4907 Hentunen,T. 244 Huang,F. 4495 Jansen,H.J. 1119,2815 Harrison,P.R. 3664 Hentze,M.W. 413 Huang,G. 2706 Jasin,M. 5012 Harroch,S. 3539 Herdewijn,P. 51,4363 Hubner,P. 4001 Jayaram,M. 3009 Harshey,R.M. 3937 Herrera,J.E. 3974 Huibscher,U. 736 Jayaraman,K. 647,4029 Hart,K.L. 2492 Herrick,G. 2006 Hug,M. 138 Jeang,K.-T. 3531 Hartlein,M. 11 13 Hertel,S. 3800 Hughes,B.J. 3792 Jeddeloh,J.A. 130 Hartley,J.A. 81 Herzing,L.B.K. 4005 Hughes,D. 464 Jendis,J. 1204 Harvey,S.C. 1816,4092 Herzog,N.K. 3345 Hughes,S.H. 2988 Jeng,S.-T. 4690 Hashido,K. 36 Hesse,H. 3355 Huizenga,B.N. 2973 Jenkins,J.R. 1836 Haslam,J. 3283 Heumann,H. 988 Humphries,S.E. 2404 Jenkins,T.C. 3627,4283 Hassman,F. 1197 Heurgue-Hamard,V. 2801 Hunter,I.S. 370 Jennings,E. 4457 Hasty,P. 2058 Heyraud-Nitschke,F. 910 Hunter,W.N. 1710 Jennings,P.A. 3922 Hata,A. 2049 Hicke,B. 1887 Hur,M. 4466 Jenny,A. 2629,4034 Author index

Jeno,P. 4034 Kanehisa,M. 419 Kersey,P.J. 4761 Kohwi,Y. 2654 Jernigan,R.L. 3531,4707 Kang,A. 4009 Kessler,J. 165 Kohyama,A. 3441 Jiang,R. 3174 Kang,C. 4488 Kessler,L.V. 3283 Koj,A. 5041 Jiang,S.-W. 3607 Kang,S.-H. 2223,2344 Khamnei,S. 3989 Kok,M. 5085 Jiang,Y-H. 3071 Kantorow,M. 442 Khong,T.F. 1307 Kolb,A. 819 Jie,J. 4303 Kaplan,A.H. 803 Khoo,B. 1775 Kolchanov,N.A. 4097 Jimenez-Garcia,E. 2464 Kaplan,J.-C. 3419 Kiefer,F. 2127 Koldin,B. 4162 Joerger,R.D. 522 Kappler,C. 1140 Kielland-Brandt,M.C. 256 Kolding,D. 467 Johanning,F.W. 1495 Kaptein,R. 3189 Kikinis,Z. 4190 Kolluri,R. 4528 Johanson,U. 464 Karas,H. 4878 Kilian,A. 2729 Komano,T. 3295 Johansson,C.S. 2037 Karathanasis,S. 1536 Kim,J. 2245,2531,2980 Kominami,R. 3771 Johnson,A.D. 1239 Karger,A.E. 3842 Kim,J.-K. 1810 Kool,E.T. 1157,2937,3547 Johnson,A.L. 2147 Karim,A.S. 2037 Kim,K. 154,3937 Koonin,E.V. 3554,4229 Johnson,B.L. 2784 Karpeisky,A. 4434 Kim,S. 1374 Koopman,P. 3365 Johnson,K.A. 1273 Karwowski,B. 4239 Kim,U.-J. 1838 Koopman,P.A. 2626 Johnson,L.F. 4649 Karyagina,A.S. 2192 Kimball,A.S. 3009 Kopatz,I. 307 Johnson,T.E. 1419 Kasai,H. 595,761 Kimball,M.L. 3009 Kopel,V. 1292 Johnston,D.A. 4934 Kashuba,E. 362 Kimura,H. 2097 Kordula,T. 5041 Johnston,L.H. 2147 Kass,D.H. 2245 Kingsbury,G.A. 2563 Korenberg,J.R. 1838 Johnston,S.L. 3074 Katada,T. 2014 Kingsman,A.J. 405,628 Korolev,S.V. 4712 Jones,A.L. 1098 Kataoka,N. 3638 Kingsman,S.M. 405,628 Kosik,K.S. 3585 Jones,P.A. 1380,4275 Katinka,M.D. 3343 Kingston,R.E. 269 Koster,H. 3126 Jonsson,M. 2413 Kato,I. 742,2367 Kinjo,M. 1795 Kotlarz,D. 819 Joos,S. 72 Kato,K. 3685 Kirpekar,F. 4576 Kotter,S. 3126 Jorgensen,T.J. 3224 Katz,D. 811 Kiseleva,E. 362 Kovacic,R.T. 3999 Joshi,C.P. 541 Kauer,M. 109 Kisselev,L.L. 4712 Koziolkiewicz,M. 4239,5000 Joshua,G.W.P. 1030 Kaufer,N.F. 4296 Kitagawa,K. 36 Kraakman,L.S. 1475 Joslyn,G. 3488 Kaufman,A. 4122 Kitajima,S. 4050 Krakowiak,A. 5000 Joswig,G. 1359 Kaufmann,G. 1744 Kitaura,M. 606 Krakowski,K. 4930 Jung,G. 2980 Kaur,R. 4932 Kiyama,R. 452,4971 Krause,S. 4034 Junghans,R.P. 2563 Kausch,A.P. 3995 Klaff,P. 4885 Krauter,K. 3691 Jdnke,N. 2371 Kavanaugh,T. 4717 Kleibl,K. 3750 Krawinkel,U. 195 Juodka,B. 1359 Kawakami,K. 2848 Klein,F. 3449 Kreibich,G. 313 Jupin,I. 535 Kawakami,T. 2127 Klein,G. 362 Kretsovali,A. 2919 Juranka,P. 803 Kazahari,K. 2236 Klein Gunnewiek,J.M.T. Kreutzer,R. 4598 Jurka,J. 170 Kazakov,S.A. 3949 4864 Krishnan,B.R. 117 Just,G. 3967 Ke,Y. 4649 Kleinhofs,A. 2729 Krupp,G. 1845 Kabotyanski,E.B. 3872 Kean,K.M. 3656 Klimasauskas,S. 1388 Kruszewski,A. 2636 Kadrmas,J.L. 2212 Keams,D.R. 1260 Klinck,R. 1722 Kubaska,W. 4345 Kahl,G. 3798 Kehler,J. 3349 Klobutcher,L.A. 2006 Kubert,M. 1271,1841 Kahlen,J.-P. 327 Kel,A.E. 4097 Klopstock,T. 10 Kubota,K. 3111 Kai,M. 2600 Kel,O.V. 4097 Knaf,A. 4657 Kucherlapati,R. 3691 Kakutani,T. 130 Keller,W. 2629 Knotts,S. 3301 Kuchta,R.D. 4109 Kalinkina,A.L. 4029 Kellogg,D.E. 1087 Knowland,J. 1664 Kudrna,D.A. 2729 Kalionis,B. 3073 Kelly,D.F. 2492 Kobayashi,E. 2608 Kugler,W. 413 Kallick,D.A. 3872 Kelly,S.M. 3393 Kobayashi,M. 2848 Kuhlcke,K. 4451 Kam,K.-M. 103 Kelman,Z. 3613 Kobayashi,T. 2608 Kuhn,A. 2593 Kamiya,H. 761,2893 Kennedy,M.A. 3962 Kober,I. 109 Kuhn,L.C. 2579 Kamp,T.J. 1050 Kent,N.A. 3786 Koch,K.S. 1098 Kuimelis,R.G. 4753 Kan,M.-C. 1691 Kerkhoff,E. 4857 Kochoyan,M. 4769 Kuiper,M. 4407 Kandimalla,E.R. 1068,3578, Kem,D. 4598 Kodra,J.T. 3349 Kulesza,H.M. 4616 4510 Kem,S.E. 4127 Kogel,D. 2621 Kulozik,A.E. 413 Kanegae,Y 2080,3816 Kers,A. 893 Kogoma,T. 3119 Kumar,R. 4932 Author index

Kumar,S. 3627 Laufs,J. 910 Li,H. 4495 Lu,M. 3426 Kunz,C. 3710 Laughton,C.A. 3627,4283 Li,J. 1590 Lucchesi,J.C. 4229 Kuprash,D.V. 427 Laurie,D.A. 2724 Li,X. 2567,4812 Lucibello,F.C. 3822 Kurata,N. 2724,2729 Lauster,R. 1997 Li,Y. 2654 Ludwig,L.B. 3792 Kurochkin,A.V. 4717 Laval,J. 3750 Li,Y.-P. 5064 Luhrmann,R. 3141,3260 Kuroda,R. 1524 Lavelle,L. 2692 Liang,G. 713 Lukyanov,K.A. 1087 Kurose,K. 3704 Lawrence,C.W. 1919 Liang,Y.-J. 4690 Lukyanov,S.A. 1087 Kusano,S. 819,827 Lazar,M.A. 811 Liao,W.-C. 4649 Lupton,J.R. 3071 Kvietikova,I. 4542 Le,H.M.T. 1276 Lieber,M.R. 5006 Lurz,R. 1468 Kwart,M. 4296 Le Blancq,S.M. 3310 Liere,K. 917 Lustig,A. 4034 Kwinkowski,M. 5000 Le Douarin,B. 876 Liljas,L. 2512 Lustig,B. 3531,4707 Kwon,B.S. 154 Le Moal,M. 4777 Lilley,D.M.J. 3363 Luthy,J. 311,4001 Kyrpides,N. 565 Le Ray,D. 1862 Lin,C.-H. 4690 Lyubomir,S. 1146 La Mantia,G. 2823 Leberman,R. 1113 Lin,H.-B. 261 Macaulay,V.M. 4283 Laalami,S. 1737 Lecchi,P. 1276 Lin,N.H. 3531 MacDermot,K.D. 2636 Laayoun,A. 1584 Lee,A.S. 475 Lin-Chao,S. 1691 MacDonald,C.C. 2614 Labhardt,A.M. 4827 Lee,B.H. 3732 Linde,S. 2361 Mache,R. 1165 Labhart,P. 2252 Lee,E. 1790,1923 Linder,S. 588 Maga,G. 2840 Labrie,C. 3732 Lee,F. 1832 Ling,M. 4924 Magaiia-Schwencke,N. Labuda,D. 170 Lee,G. 3816 Link,G. 917 1614 LaCasse,E.C. 1647 Lee,H.-M. 4922 Linskens,M.H.K. 3244 Mager,W.H. 1475 Lacombe,M.L. 3858 Lee,H.H. 675 Lion,T. 4736 Magnusson,K.P. 362 Lacoste,J. 4042,5073 Lee,H.S. 1948 Lippard,S.J. 4066 Maher,L.J.III 500,1936 Lagnel,C. 1447 Lee,J.-S. 925 Lipps,H.J. 1704 Mai,S. 1 Lahiri,D.K. 3609 Lee,K.-F. 103 Liquier,J. 1722 Maier,J.A.M. 4603 Lahmy,S. 4963 Lee,K.-L.D. 4262 Lis,J.T. 4799 Maiolo,A.T. 2328 Lain,S. 1327 Lee,M.G.-S. 3310,4893 Lisitsky,I. 2506 Maizel,J. 1632 Laird,P.W. 1273 Lee,S.-T. 4683 Lithgow,G.J. 1419 Majarian,W.R. 522 Lajoinie,O. 4015 Lee,V.H. 2706 Little,R.D. 1576 Mak,T.W. 2127 Lakey,N.D. 4922 Lee,Y. 634 Littlewood,T.D. 1686 Makino,K. 123 Lam,E. 3778 Lefebvre,Y.A. 1647 Liu,H. 165,4009 Makowski,G.S. 3788 Lam,H.-Y.P. 4262 Leffert,H.L. 1098 Liu,J. 4844 Maley,F. 869 Lam,Y.K.-P. 3778 Legrain,P. 4864 Liu,K. 4116 Maley,G.F. 869 Lamb,P. 3283 Lehmann,C. 4827 Liu,R. 3742 Maliga,P. 2544 Lamontagne,S. 1717 Lehrach,H. 3842 Liu,W.-M. 1758 Malik,S. 1536 Lancelot,G. 788 Leibowitz,M.J. 1284 Liu,W.M. 1750 Maller,J. 1887 Landgraf,R. 3516,3524 Lemaltre,G. 3343 Liu,Y. 1284 Malmstrom,T.A. 2259 Landsman,D. 1019,1604, Lemieux,C. 2519 Liu,Y.S. 1640 Maltese,J.-Y. 1146 2685 Leng,M. 949,2381 Ljungman,M. 1782 Malvy,C. 3831 Langgut,W. 2488 Lennon,G.G. 4415 Lloyd,A.J. 2886 Mancino,V. 1990 Langle-Rouault,F. 3079 Leontis,N.B. 2212 Lloyd,D.H. 2661 Mandecki,W. 4717 Langley,E. 1140 Lerman,L.S. 2775 Lloyd,R.S. 1398 Manet,E. 4939 Langlois,I. 2341 Lemer,C.P. 1273 Loakes,D. 2361,4363 Manivasakam,P. 2799 Langlois d'Estaintot,B. 1710 Lescot,E. 3850 LoBuglio,A.F. 1495 Manley,J.L. 3260 Lanz,R.B. 138 Lesnik,E.A. 2019 Lombardi,L. 2328 Mannering,S.A. 1487 Lapadat-Tapolsky,M. 2434 Lessard,C. 745 Longo,L. 2823 Manning,A. 3578 Lapeyre,B. 1912 Leupin,W. 4827 Lonnberg,H. 1170,4255 Manning,A.N. 4510 Lareau,F. 745 Leviev,I. 1512 Lorimer,I.A.J. 3067 Manor,H. 1292 Larrouy,B. 64,3434 Levieva,S. 1512 Lorsch,J.R. 2811 Mantovani,R. 1657,4565 Larsen,N.I. 1223 Levine,B.J. 491 Losson,R. 876 Mao,B. 2314 Latham,S.E. 3073 Lewis,H. 4913 Lother,H. 4451 Mao,J. 4922 Lathan,C. 3578 Li,B. 2314 Lou,L. 3481 Mao,W. 4007 Laudet,V. 881 Li,C. 4426 Low,R.L. 88 Marians,K.J. 1374 Author index

Marie,J. 3419,3501 1091 Migliazza,A. 2328 Morin,B. 3954 Mariottini,P. 4670 McCuaig,K.A. 1948 Mikulits,W. 2342 Moriya,H. 595 Markie,D. 720,1830,4526 McDonald,C.D. 500 Miles,H.T. 4116 Morl,M. 3380 Marondel,I. 3691 McElver,J. 2799 Miller,J.H. 515 Morley,S.J. 334 Marques,J.P. 1970 McGee,D. 2019 Miller,L. 4502 Morris,J. 2292 Marquis,J.C. 5027 McGinnis,W. 3481 Miller,P.F. 3980 Morris,R.C. 2492 Marsch,G.A. 1252 McGraw,P. 1426 Miller,R.D. 2339 Morse,S.E. 302 Marsh,T.C. 696 McHugh,P.J. 1664 Milligan,J.F. 2184 Mortin,M.A. 1882 Marshall,J. 2945 Mclnemy,C.J. 4761 Millinoff,D. 4353 Morton,B.S. 1597 Martensson,I.-L. 1 Mclninch,J.D. 3554 Milner,J.J. 176 Morzaria,S.P. 1942 Marti,H.H. 4542 McKenzie,R.A. 146 Milocco,L. 3283 Mosca,P.J. 261 Martin,A. 1642 McKenzie,T.L. 2259 Mine,E. 2648 Moskaluk,C.A. 4127 Martin,F. 779 McKeown,B.J. 2337 Minnee,R. 1475 Moudrianakis,E.N. 2685 Martin,N. 856 McLaughlin,L.W. 4753 Minobe,Y. 2724 Mount,R.C. 995 Martinez,M.A. 2573 McLean,M.J. 4283 Minton,N.P. 3357 Muchardt,C. 1127 Martinez-Balbals,M.A. McMillan,P.J. 942 Mironov,V.N. 3359 Muckenthaler,M. 405 2464 McStay,B. 4583 Mischiati,C. 1671 Mueller,J.P. 3457 Martins de Sa,C. 2198 Mechulam,Y. 4793 Mishima,Y. 3771 Mukai,T. 36 Marton,R.F. 4443 Medberry,S.L. 485 Missbach,M. 327 Mukhopadhyay,S. 3076 Maruyama,H.I. 3796 Medigue,C. 3554 Mitani,K. 2762 Muldoon,S. 675 Maruyama,I.N. 3796 Meersseman,G. 1075 Mitas,M. 1050,2706,4055 Muller,A.K. 1894 Marvin,W.B. 3600 Meier,T. 988 Mitchell,D.L. 4934 Muller,F. 4628 Marzabal,S. 3648 Meier-Ewert,S. 3842 Mitchell,J.E. 1876 Muller,H.-P. 2277 Marzluff,W.F. 654,4734 Meijer,W.J.J. 612,3214 Mitchelmore,C. 2479 Muller,O. 3800 Mason,T.L. 3673 Meira,L.B. 1614 Mittrucker,H.-W. 2127 Muller,R. 3822 Masta,A. 3508 Mekhalfia,A. 211 Miura,H. 2893 Muller,U. 1441 Masuda,J. 36 Melese,T. 1912 Miyashita,A. 293 Muller-Hill,B. 4162 Masutani,C. 2893 Mellor,J. 3786 Miyoshi,H. 2762 Mullner,E.W. 2342 Mathews,M.B. 3732 Melo,C.A. 238 Moda,I. 3638 Munro,H.N. 4190 Matlashewski,G. 4073 Melov,S. 1419,4122 Model,P. 2030 Munz,P.L. 1036 Matray,T.J. 4642 Meltzer,P.S. 4127 Moe,J.G. 1984 Murata-Kamiya,N. 2893 Matsarskaia,M. 796 Menard,S. 4603 Moelling,K. 1204 Murayama,H. 123 Matsuda,A. 4677 Mendoza,A.R. 2120 Moen,T.C. 248 Murdaugh,S.E. 2775 Matsui,P. 767 Meneghini,R. 2995 Mohun,T. 4267 Murnane,J.P. 2837 Matsukage,A. 761 Meng,B. 3967 Molinaro,M. 3056 Murray,J.B. 2512 Matsumoto,K. 3493 Menotti,E. 2579 Moller,U. 4657 Murray,K. 1531 Matsuyama,T. 2127 Merante,F. 4924 Molnar,G. 3318 Murray,N.E. 967,1177 Matteucci,M.D. 1197 Mercier,J.-P. 2519 Moncollin,V. 1657 Murtin,C. 2959 Matthews,J.R. 3393 Merle,A. 3831 Money,T.A. 2724 Muscat,G.E.O. 1311,2626 Matulic-Adamic,J. Merrell,K. 3865 Mongelli,N. 81,1657,4565 Musier-Forsyth,K. 165 3989,4434 Merville,M.-P. 1341 Monnot,M. 3831,3850 Musso,M. 2320 Matvienko,N.I. 1213 Mesnildrey,S. 3858 Montag,K. 2168 Mutter,G.L. 1411 Matvienko,N.N. 1213 Methot,D. 4551 Montecucco,A. 962 Muyzer,G. 4928 Mauffret,O. 3850 Meunier,B. 3894 Montfort,W.R. 869 Myler,P.J. 708 Mautner,J. 72 Meyer,G. 4928 Montgomery,K. 3691 Naeve,G.S. 475 Maxwell,E.S. 4844 Mfou'ou,V. 395 Moore,G. 2724 Nahon,J.-L. 3353 May,D.L. 3252 Mi,S. 620,1380 Moore,M. 351 Naiman,T. 307 Mazumder,A. 2865,2872 Miao,D.-M. 3295 Mora,L. 2801 Nakahigashi,K. 4383 McAteer,K. 3962 Miaskiewicz,K. 515 Morad,I. 1744 Nakai,M. 3816 McCall,M.J. 3922,3928 Michaelson,J.S. 975 Morales,J.F. 2837 Nakamuta,H. 123 McClanahan,T. 1832 Michalak,M. 3268 Morby,A.P. 729 Nakatani,Y. 1882,4557 McClellan,J.A. 1876 Michain,C.M. 1518 Morelli,D. 4603 Nameki,N. 389,2831 McCormick-Graham,M. Michot,B. 2669 Morgan,M.A. 3949 Narayanswami,S. 3995 Author index

Nash,H.A. 2973 Ogata,H. 419 Pardee,A.B. 3318 Planta,R.J. 1475 Nashimoto,M. 3642 Ogata,J. 36 Pardon,B. 932 Pleij,C.W.A. 3718 Nasim,A. 383 Ogawa,K. 3790 Park,H. 4337 Plunkett,G. 2105 Nassal,M. 3909,4954 Ohgi,T. 761 Parker,M.G. 1686,4143 Poklemba,C.J. 2569 Natarajan,D. 4003 Ohira,M. 2762 Parsons,I.D. 211 Polack,A. 72 Nazar,R.N. 634 Ohishi,S. 36 Pascale,E. 879 Polaskova,J.A. 491,4180,4391 Nedospasov,S.A. 427 Ohki,M. 2762 Pasman,Z. 3260 Politz,J.C. 4946 Neidle,S. 3627,3678,4283 Ohki,R. 4971 Pastan,I. 3067 Polkinghorne,I. 188 Nelissen,R.L.H. 4864 Ohlmann,T. 334 Patel,R. 2025 Pommier,Y. 2865 Nemeth,A. 4034 Ohno,M. 3638 Patel,U.A. 4262 Pommier,Y.G. 2872 Nerenberg,M. 2223,2344 Ohshima,A. 2367 Patterson,T.E. 4222 Pon,R.T. 3916 Neri,A. 2328 Ohtsuka,E. 2893 Patterton,H.-G. 4170 Ponnazhagan,S. 154 Neuman,T. 1696 Oishi,M. 452,4971 Paule,M.R. 4345 Poole,E.S. 4104 Neumann,F. 195 Okada,N. 389 Pays,E. 1862 Porteous,D.J. 1644 Neupert,B. 2579 Okamoto,S. 3295 Payson,R.A. 434 Porter,A.C.G. 1854 Newbury,S.F. 1876 Okamoto,T. 1445 Pearse,M. 1307 Porter,A.G. 377 Nguyen,H.T. 541 Okuda,M. 3295 Pebler,S. 3710 Porter,K. 4495 Nguyen,M. 1717 Olivas,W.M. 1936 Peck,L.J. 1551 Portier,C. 18 Ni,Y.-S. 3026 Olmo,A. 2856 Pedersen,J.B. 753,4576 Pot,J. 4407 Nicholson,J. 3393 Olopade,O.I. 1085 Pedroso,E. 4151 Powell,L.M. 967,1177 Nickel,J. 4785 Olson,M.O.J. 3974 Pedroso,P. 2292 Power,D. 1307 Nicolas,A.L. 1036 Onnekink,C. 1119,2815 Peleg,M. 1292 Pozzi,B. 4603 Nicolas,E. 1140 Ono,A. 4677 Peleman,J. 4407 Prakash,K. 313 Nicoloso,M. 2669 Ono,M. 2236 Pennings,S. 1075 Prasad,R. 1597 Nielsen,D.A. 2287 Onufryk,C. 1127 Perelman,B. 307 Praseuth,D. 4042 Nielsen,P.E. 217 Oren,M. 2584 Perler,F.B. 1030 Pratviel,G. 3894 Niemer,I. 2966 Orgel,L.E. 1083,3742 Pernelle,C. 2434 Preiser,P. 4329 Nikolskaya,I.I. 2192 Orozco,E.M. 4690 Peronnet,F. 5073 Prentki,P. 2959 Nishiguchi,T. 3887 Osswald,M. 4635 Perreault,J.-P. 745,3064 Prescott,D.M. 1279,1887 Nishihara,T. 606 Ostertag,W. 4451 Perrino,F.W. 1003 Prevost,F. 788 Nishikawa,J. 606 Osvath,S. 1307 Persson,B. 211 Pribnow,D. 4471 Nishikawa,Y. 3790 Otis,C. 2519 Pesenti,E. 81 Price,N.C. 3393 Nishimura,S. 2893 Otsuka,M. 1524 Peter,H.-H. 195 Primig,M. 3449 Nishizawa,M. 2608 Otte,J. 3710 Peterson,R. 165 Prinz,S. 3449 Noble,S.A. 1197 Oursler,M.J. 4907 Peterson,S.R. 2770' Pritlove,D.C. 2641 Noguchi,C.T. 3041 Ouzounis,C. 565 Petrauskene,O.V. 2192 Pullner,A. 3373 Nomura,Y. 742 Ow,D.W. 485,1923 Pfleiderer,W. 2872 Purvis,I.J. 2348 Noonberg,S.B. 1956,4042 Owens,S.R. 2019 Philippe,C. 18 Qian,X. 1184 Novo,F.J. 2636 Ozoline,O.N. 4533 Phillips,D.R. 42,2450,3508 Qin,M. 485,1923 Novoradovsky,A. 2287 Paabo,S. 3380 Phillips,R.A. 5087 Qu,L.-H. 2669 Novotny,M. 2538 Paci,M. 1333 Phillips,W.A. 1640 Quandt,K. 4878 Nozaki,N. 2097 Pagano,J. 1729 Piatigorsky,J. 442 Quentin,Y. 2900 Nunn,C.M. 3678 Paietta,J.V. 1044 Piatyszek,M.A. 3794 Quitschke,W.W. 2734 Nurse,P. 203 Pain,V.M. 334 Pickard,R.T. 154 Qureshi,S. 459 O'Dell,S.D. 2404 Palme,K. 1970 Piercy,R. 2337 Qureshi,S.A. 1775 O'Donnell,M. 3613 Pan,C. 3673 Pierrat,B. 876 Radebaugh,C.A. 4345 O'Leary,N. 3318 Pan,W.-J. 1561 Pierron,G. 1447 Radman,M. 3944 O'Neill,T.E. 1075 Panagiotidis,C.A. 1800 Pietsch,S. 3800 Radtke,F. 2277 O'Prey,J. 3664 Panetta,G. 2914 Piette,J. 1341 Ragoussis,J. 1830 Ochem,A. 2457 Pannell,L.K. 1276 Pike,M.J. 1495 Raguenez,G. 395 Oda,N. 3041 Panvert,M. 4793 Pilipenko,E.V. 1870 Raible,A.M. 2754 Odelberg,S.J. 2049 Papa,S. 10 Pillet,N. 4363 Rajasekaran,A.K. 313 Ofengand,J. 3290 Papamatheakis,J. 2919 Pipe,A. 1197 Rajewsky,K. 5080 Author index

Rakow,T.L. 3796 Riesner,D. 4246,4524 Rudiger,N.S. 256 Sasisekharan,V. 4510 Ramalingam,R. 3018 Riggs,A.D. 98 Rudinger,J. 4598 Sato,N. 2161 Ramani,N. 2030 Riggs,B.L. 4907 Ruggeberg,H. 4928 Sato,Y. 3816 Ramasamy,K. 3003 Riggs,D.L. 1231 Ruiz-Perez,L.M. 2856 Satoh,H. 1524 Ramaswamy,V. 1146 Rigler,R. 1795 Rumney,S.,IV 3547 Savini,E. 962 Ramsdale,E.E. 628 Riley,G.R. 708,3093 Rusconi,S. 138 Savkur,R. 3974 Ramser,J. 3798 Rill,R.L. 1252 Russchen,B. 2389 Sawaya,B.E. 2206 Rao,T.S. 647 Rinaldi,M. 4134 Russu,I.M. 1984 Sax,C.M. 442 Rasmussen,K. 4907 Rinaldo,J.E. 3132 Rutigliano,C. 1671 Sazer,S. 4222 Rastogi,H. 4872 Rindt,H. 3301 Ryan,A.K. 3232 Scaringe,S. 2677 Ratz,I. 4451 Risen,L.M. 2019,3003 RYe,H.S. 1215 Schaefer,S. 910 Rau,M. 334 Rivera-P6rez,J. 2058 Saati,S.M. 3244 Schaeffer,E. 2206 Rausch,H. 58 Rivolta,M.N. 2565 Saedler,H. 1901 Schaffner,W. 736,2277,4978 RautenstrauB,K. 230 Robbins,J. 3301 Sagar,S. 2492 Schell,J. 910 Ravagnan,G. 1333 Roberts,C.J. 4818 Sagawa,H. 2367 Schellhorn,H.E. 3076 Ravagnani,A. 3069 Roberts,R.J. 620,1388 Sage,C. 4844 Schepers,G. 4363 Ravin,A.J. 2212 Robinson,B.H. 4924 Sahasrabudhe,P.V. 3916 Schickor,P. 988 Ray,D.S. 2526 Robinson,N.J. 729 Saifudeen,Z. 3026 Schiestl,R.H. 2799 Rea,S. 1311 Robinson,P.J. 729 Saison-Behmoaras,T. 3411 Schindewolf,C.A. 1133 Reardon,B.J. 4900 Robles,J. 4151 Saito,I. 2080,3816 Schlichter,U.H.A. 4520 Reddy,R. 2421 Robson,C.N. 1544 Saitoh,A. 2014 Schmaltz Hill,T. 4029 Reed,R. 4081 Rojo,F. 1894,3181 Sakaguchi,K. 2600 Schmelzer,C. 2966 ReichhartJ.-M.,1140 Hoffm Romanienko,P.J. 5012 Sakaguchi,T. 2893 Schmid,B. 3093 Reichmann,H. 10 Romaniuk,P.J. 277 Sakai,H. 3295 Schmid,C.W. 1750,1758 Reid,B.J. 3488 Romano,G. 628 Sakaki,T. 3816 Schmid,H. 58 Reijans,M. 4407 Romaschenko,A.G. 4097 Sakaki,Y. 3704 Schmidt,M.C. 3174 Reinbolt,J. 779 Romero,D.P. 1091 Sakamoto,H. 3441 Schmidt,S. 2192 Reiners-Schramm,L. 1997 Romling,U. 722 Sakamoto,S. 123 Schmidt,U. 58 Reisser,T. 2488 Ronchi,A. 4565 Sakamoto,Y. 3493 Schmitt,E. 4793 Reitman,M. 1790 Ronne,H. 4421 Sakurai,H. 2648 Schmitt,M. 3887 Rempel,R. 1887 Roopra,A. 670 Sala,M. 2573 Schmitz,A. 4785 Renalier,M.-H. 2669 Rosen,J. 3283 Salamini,F. 2168 Schmutte,C. 4275 Renkawitz,R. 4785 Rosenberg,H.F. 4290 Salier,J.-P. 395 Schneider,K. 1570 Rentier,B. 1341 Rosendahl,G. 2396 Samarsky,D.A. 2548 Scholler,P. 3842 Reszka,A.P. 4283 Rosenthal,N. 2988 Sampson,K. 1729 Schoonbroodt,S. 1341 Reudelhuber,T.L. 4551 Rosier,M.-F. 1642 Samstag,Y. 3347 Schrader,M. 327 Reuning,U. 3887 Rossi,J.J. 2223 Sancar,G.B. 4320 Schreiber,D.R. 4391 Revankar,G.R. 647 Roth,D.B. 3872 Sandaltzopoulos,R. 2479 Schroth,G.P. 1977 Revel,M. 3539 Rothbarth,K. 1359 Sander,C. 565 Schubert,F. 4657 Rhee,Y. 3275 Rottman,F. 2421 Sander,E.E. 2593 Schuller,H.-J. 230 Rho,H.M. 2980 Rouet,P. 395,5012 Sandusky,P. 4717 Schulte-HerbriUggen,T. Rhodes,C. 2305 Rouquier,S. 4415 Sano,T. 3995 2427 Riblet,R. 2339 Rousset,J.-P. 1557 SantaLucia,J.Jr 4913 Schultz,R.G. 2661 Rice,N.R. 427 Rowlands,T. 1775 Santi,D.V. 4677 Schumacher,S. 910 Rich,A. 4488 Roy,P. 188 Santiago,F.S. 3922 Schumperli,D. 3141,3152 Richards,E.J. 130 Roy,R.N. 3076 Santos,M.A.S. 1481 Schuster,G. 2506 Richardson,C.D. 2127 Rozenblum,E. 4127 Sanzgiri,R.P. 1766 Schuster,H. 1468 Richardson,T. 3798 Rozenski,J. 51,4363 Saparbaev,M. 3750 Schutte,M. 4127 Richert,C. 2427 Rubin,E. 3547 Sardet,C. 1127 Schwab,G. 3411 Richmond,A. 4210 Ruckert,B. 1468 Saris,C.P. 1300 Schwank,S. 230 Richterich,P. 4922 Rudd,K.E. 3554 Sarkar,G. 1269,3074 Schwartz,S.A. 3792 Riedel,H.-D. 1468 Ruddell,C.J. 954 Sasaki,M. 123 Schwarzbauer,J.E. 3335 Rieger,A. 3909 Ruddle,F.H. 4850 Sasaki,T. 2729,2893 Schwarzman,A.L. 2734 Author index

Schweizer,D. 3449 Shobuike,T. 357 Soneoka,Y. 628 Stonehouse,N.J. 2512 Schweizer,E. 230 Shoffner,J.M. 4122 Song,W. 3609 Stormo,G.D. 1434 Schwenk,F. 5080 Shore,G.C. 1717 Soni,S.-D. 1810 Strating,M.J. 3189 Schwienhorst,A. 1834 Shore,P. 2442,4698 Sonti,S.V. 3995 Strausbauch,M. 3074 Schwinn,S. 3347 Short,M.L. 4785 Sorrentino,R. 2078 Strazzullo,M. 2823 Sebillon,P. 3419 Shterman,N. 1744 Sourgen,F. 3850 Strobl,L.J. 3373 Secco,A.S. 2065 Shulemovich,K. 811 Sozer,A.C. 3050 Struhl,K. 2531 Sedivy,J.M. 2803 Siderovski,D.P. 2127 Spadari,S. 2840 Stuart,K. 708,3093 see,R.H. 925 Siebert,P.D. 1087 Spahr,P.-F. 861 Stults,J.T. 2754 Seela,F. 2499 Sierzputowska-Gracz,H. Spanopoulou,E. 3473 Stunkel,W. 109 Seeman,N.C. 3363 146 Sparrow,D.B. 4267 Sturges,M.R. 1551 Seibel,P. 10 Sigman,D.S. 3516,3524 Spelsberg,T.C. 4907 Su,L. 4488 Seidel,H.M. 3283 Silveira,M.H. 1083 Spielmann,H.P. 1576 Subramaniam,M. 4907 Seifart,K.H. 109 Silverman,R.H. 3989 Spierer,P. 796 Suckow,M. 4162 Sekeris,C.E. 2742 Silversides,D.W. 4551 Spiess,E. 1359 Suda,T. 3771 Selivanova,G. 362 Silverstein,S.J. 1800 Spiller,D.G. 954 Sudor,J. 2538 Selker,E.U. 4818 Simard,C. 2341 Spitzner,J.R. 4488 Sugano,S. 357,3816 Sergeant,A. 4939 Simon,M.I. 1838 Spom,S.A. 3335 Sugimoto,K. 2097,3493 Sergeyev,D.S. 4400 Simpson,A.J.G. 192 Sprague,K.U. 1244 Sugimoto,N. 123 Seripa,D. 4134 Simpson,E.M. 1273 Sproat,B. 3434 Sulo,P. 856 Serrano-Lopez,A. 5048 Simpson,R.T. 4170 Sproat,B.S. 64 Sulston,J. 670 Servaes,S. 2988 Sindelar,L.E. 982 Sprous,D. 1816 Sumerel,L.A. 1495 Seth,D.M. 647 Singer,R.H. 4946 Srivastava,D.K. 3810 Sun,F. 3034 Seto,D. 4930 Singhal,R.K. 1597 Stade,K. 2371 Sun,L.Q. 2909 Seto,J. 4930 Sippel,A.E. 2076 Staden,R. 1406,4992 Supakar,P.C. 3026 Seydel,A. 4162 Sirand-Pugnet,P. 3501 Stahl,G. 1557 Sutrave,P. 2988 Shaffer,C. 2677 Sirdeshmukh,R. 641 Staknis,D. 4081 Suwa,A. 2770 Shain,D.H. 1696 Sista,N.D. 1729 Standart,N. 2198 Suzuki,K. 4664 Shaiu,W.-L. 1766 Skopac,D. 2457 Stanker,L.H. 4836 Suzuki,M. 2083 Shamoo,Y. 725 Slekar,K.H. 1964 Stanley,J.S. 942 Svensson,C. 588 Sharma,H.W. 1146 Slightom,J.L. 4353 Stark,G.R. 4222 Svinarchuk,F. 3831 Sharpe,A.H. 1273 Smerdon,M.J. 3457 Stashenko,P. 5064 Swaminathan,S. 844 Sharrocks,A.D. 2442,4698 Smidt,M.P. 2389 Stawinski,J. 893 Swank,R.A. 1887 Shaw,B.R. 4495 Smih,F. 5012 Stec,W. 4239 Swanstrom,R. 803 Shaw,P.-C. 103 Smit,A.F.A. 98 Stec,W.J. 530,5000 Sweder,K.S. 2715 Shay,J.W. 3794 Smith,D. 4922 Steensma,H.Y. 883 Sweedler,D. 2677,4434 Shayeghi,M. 383 Smith,D.L. 1239 Stefanini,M. 962 Swenberg,C.E. 2314 Sheaff,R.J. 4109 Smith,F.W. 4320 Stefanovic,B. 3141,3152 Swiderski,P. 2223 Shen,J.-C. 1380,4275 Smith,G.K. 4303 Steffen,M. 856 Swift,S. 1426 Shen,K. 3041 Smith,H.D. 1830 Steffenson,B. 2729 Symonds,G. 2909 Shen,L. 2120 Smith,K.F. 4992 Steger,G. 4524 Syvaoja,J.E. 244,2178 Shen,L.X. 4913 Smith,M.C.M. 370 Stehelin,D. 881 Szab6,T. 893 Sheng,Y. 1990 Smith,S.M. 3531 Stein,C.A. 3726,4239 Szekely,L. 362 Shenk,T. 4457 Smith,S.S. 1584 Stein,P.C. 4576 Szostak,J.W. 2811 Shevchenko,A.V. 2571 Smith,T.P.L. 1244 Stein,R.B. 3283 Tabler,M. 1192 Shi,Y. 925 Snippe,L. 2389 Steinberg,R.A. 1621 Tada,S. 2014 Shi,Y.-B. 2555 Sobolev,I.A. 2881 SteinbiB,H.-H. 4520 Tagami,H. 599 Shimba,S. 2421 Soeda,E. 2762 Steiner,J.J. 2569 Taillandier,E. 1722 Shimizu,K. 2762 Sofia,H.J. 2105 Stewart,A.F. 3168 Taimor,G. 109 Shimizu,M. 389 Sohanpal,B.K. 1942 Stinchcomb,D.T. 2259 Takahashi,H. 827 Shimura,Y. 3441,3638 Soll,D. 2886 Stockley,P.G. 211,2512 Takahashi,O. 3493 Shinomiya,M. 1524 Sollerbrant,K. 588 Stolow,D.T. 835 Takahashi,T. 2600 Shizuya,H. 1838 Sompayrac,L. 4738 Stolow,M.A. 2555 Takechi,S. 4196 Author index

Takechi,T. 869 Timmermans,V. 1679 Valerie,K. 3764 Vostrov,A.A. 2734 Takizawa,N. 2097 Tinoco,I.Jr 3056,4913 van Aarssen,Y 4864 Vovelle,F. 788 Talbot,S.J. 2512 Tkach,T. 4805 Van Aerschot,A. 51,4363 Waddell,S. 1836 Talibi,D. 550,558 TocchiniValentini,G.P. 2914 van Batenburg,F.H.D. 3718 Wagner,E.G.H. 571,580 Tanaka,K. 827,3295 Todo,T. 2600 Van Beeumen,J. 51 Wagner,R. 932,3944 Tanaka,M. 3816 Tokusashi,Y. 3790 van de Lee,T. 4407 Wagner,R.W. 1197 Taneja,K.L. 4946 Tomino,S. 2648 van de Putte,P. 1679 Wahle,E. 4034 Taneja,P. 2457 Tonkin,L.A. 3244 van den Engh,G. 4415 Wain-Hobson,S. 2573 Tang,K. 3126 Tonkinson,J.L. 4239 Van der Ploeg,L.H.T. 1010 Wakimoto,H. 2080 Tang,S. 1928 Torrence,P.F. 3989 van der Vliet,P.C. 3189 Walker,L.J. 1544 Taniguchi,T. 2127 Toselli,E. 1642 Van Dyke,M.W. 2320 Wall,G. 2479 Tari,L.W. 2065 Toulme,J.-J. 64,3434 van Gerven,B. 1119 Wallace,D.C. 4122 Tate,W.P. 1487,4104 Tracz,D. 2677 van Leeuwen,H.C. 3189 Wallace,J.C. 1810 Taussig,M.J. 4009 Trappe,J. 10 Van Montagu,M. 3359 Walther,Z. 3756 Tavassoli,M. 383 Trask,B.J. 4415 van Rosmalen,A. 42 Waltzer,L. 4939 Tavernarakis,N. 537 Travis,J. 5041 Van Ryk,D.I. 634,3563 Wang,C.C. 1030 Taviaux,S. 4415 Trecca,D. 2328 van Tongeren,S. 3214 Wang,D. 3967 Taylor,K.B. 2472 Treiber,D.K. 3603 van Venrooij,W.J. 4864 Wang,D.G. 4742 Tedesco,P.M. 1419 Treisman,R. 4267 Vandeberg,B. 4320 Wang,H. 2654 Teebor,G.W. 3239 Trent,J.M. 4127 Vanhamme,L. 1862 Wang,J. 925,3260 Teigelkamp,S. 320 Trexler,E.B. 4844 Varani,G. 341 Wang,K.Y. 844 Tejada,M.L. 3252 Trka,J. 4736 Vartanian,J.-P. 2573 Wang,L. 2909 Temsamani,J. 1271,1841 Tronche,F. 395 Vasa,M.Z. 2137 Wang,S. 1157,2937,3547 Tenen,D.G. 4738 Trotta,E. 1333 Vaudin,M. 670 Wang,S.X. 2929 Teng,S.-C. 2929 Trower,M.K. 2348 Vaury,C. 4015 Wang,T.S.-F. 4337 Terenius,L. 362 Truss,M. 3822 Velhagen,I. 3347 Wang,X. 36 Termini,J. 3275 Tsyganov,M.A. 4533 Venema,G. 612,3214 Ward,L.J. 2567 Tessmer,C. 3347 Tucker,J.D. 4836 Venkataraman,G. 4510 Waring,M.J. 885 Teunissen,A.W.R.H. 883 Tuerk,C. 3198 Verhage,R. 1679 Waring,R.B. 4466 Tharun,S. 641 Tuite,M.F. 1481 Wron,M. 3858 Wamecke,G. 4023 Theil,E.C. 146 Tullius,T.D. 3009 Vesenka,J. 696 Warshawsky,D. 4502 TheiBen,G. 1901 Tummler,B. 722 Vickers,T.A. 3003 Wassenaar,R. 4864 Thielking,V. 3648 Turmel,M. 2519 Vidal,F. 2734 Watakabe,I. 3441 Thierry,F. 4777 Tumer,R.E. 869 Villa,L.L. 192 Watanabe,T. 1524 Thireos,G. 537 Turri,M.-G. 1854 Villani,G. 10 Waterman,M.S. 3034 Thomann,H.-U. 2886 Tuteja,N. 2457 Villeponteau,B. 3244 Waterston,R.H. 670 Thomas,R.J.S. 1640 Tuteja,R. 2457 Vincent,C. 1113 Watts,F.Z. 383 Thomas,T. 3594 Tuusa,J. 2178 Vincent,M. 3206 Watts,G.S. 4740 Thomas,T.J. 3594 Udomkit,A. 1354 Vissers,S. 558 Wawer,C. 4928 Thomm,M. 3837 Ueda,T. 761 Vlassov,V.V. 3161 Weaver,D.T. 1060 Thommes,P. 4443 Uhlenbeck,O.C. 2092 Vo,T. 2937 Weavind,G.P. 2404 Thompson,E. 4745 Uitto,L. 244,2178 Voeller,D.M. 869 Weber,J.A. 3327 Thompson,H.C. 4109 Ulanovsky,L.E. 2881 Vogel,A.M. 4087 Weber,S.C. 2799 Thompson,J.D. 2259 Ulyanov,A.V. 1434 Voit,R. 2593 Wedel,A. 988 Thompson,L.H. 4836 Urban,C. 4591 Volkmann,S. 1204 Wegmuller,B. 311 Thompson,M.D. 4745 Urmenyi,T.P. 1010 vom Baur,E. 876 Wei,H. 4528 Thompson,R.D. 2168 Usdin,K. 539,4202 von der Ahe,D. 3710 Wei,L.I.C. 3076 Thompson,S.A. 1197 Usher,D.A. 4872 von Kitzing,E. 3363 Weiner,L. 2030 Thorbum,A.M. 405 Usman,N. 2677,3989,4092, von Mikecz,A. 195 Weinfeld,M. 3805,3954 Thoung,N.T. 788 4434 von Wilcken-Bergmann,B. Weintraub,B.D. 4224 Thyagarajan,B. 2784 Vaghefi,M.M. 3600 4162 Weising,K. 3798 Tidd,D.M. 954 Valegard,K. 2512 Vos,P. 4407 Weiss,R.B. 2049 Tillman,T.S. 3174 Valentine,M.R. 3275 Vossen,K.M. 2346 Weissman,S.M. 4528 Author index

Weitzmann,M.N. 539 Wiman,K.G. 362 Yang,M.-T. 4690 Zhu,H. 3310 Welch,S.G. 4573 Wincott,F. 2677 Yang,Q. 4345 Zhu,W. 4353 Weltman,J.K. 2037 Wingender,E. 4097,4878 Yang,T.-A. 2803 Zichi,D.A. 4471 Wemmer,D.E. 753,1576 Winkles,J.A. 434 Yaniv,M. 1127,4777 Zietkiewicz,E. 170 Wen,J.-P. 1704 Winter,E. 4900 Yannopoulos,C.G. 3967 Ziff,E.B. 4857 Wen,Z. 459 Winterhalter,K.H. 1396 Yano,M. 2729 Zimarino,V. 467 Wenger,R.H. 4542 Wirth,S.S. 2706 Yano-Yanagisawa,H. 2654 Zingg,J.-M. 1380,4275 Wenzel,T.J. 883 Wise,C. 856 Yant,S.R. 4353 Zlotnik,A. 1832 Wemer,D. 1359 Withers,B.E. 3571 Yarema,K.J. 4066 Zmudzka,B.Z. 3810 Werner,M. 2092 Witt,I. 4296 Yasukochi,Y. 4050 Zorbas,H. 1443 Werner,T. 72,4878 Wittop Koning,T.H. 3152 Yeatman,T.J. 4007 Zoumadakis,M. 1192 West,S.C. 3621 Wolf,D.A. 3373 Yokoyama,K. 2762 Zuber,G. 3161 Westhof,E. 18 Wolffe,A.P. 4557 Yonaha,M. 4050 Zuber,M.X. 1696 Westin,L. 2184 Wong,K.K. 3865 Yoneyama,T. 2236 Zuiderweg,E.R.P. 2153,4717 Westphal,H. 1790 Wood,A.A. 3678 Yoon,J. 4087 Zuker,M. 2791 Wettstein,P.J. 3074 Wood,L.D. 4210 Yoshida,Y. 2080 Zunino,F. 223 Wheeler,D.G. 3268 Wood,Z.A. 1816 Yoshinaga,S.K. 2127 Zuo,S. 3239 White,J.H. 1948,3268 Woodford,K. 539 Youil,R. 5082 Zwicker,J. 3822 White,R. 2049 Woodford,K.J. 4202 Young,C.S.H. 1036 White,S.W. 4058 Wooten,E.W. 4717 Young,K.M. 3600 Whittaker,E. 320 Workman,C. 2677 Young,L.S. 1244 Whitton,B.A. 729 Wrange,O. 2184 Yu,A. 1050,2706,4055 Widmer,G. 2300 Wright,E. 3365 Yu,S.-M. 4683 Wieland,S. 138 Wright,J.A. 1461 Yung Yu,C. 2120 Wienecke,A. 1834 Wright,J.H. 1454 Yura,T. 4383 Wiesenberg,I. 327 Wright,M. 1495 Zabeau,M. 4407 Wieslander,L. 310 Wright,W.E. 3794 Zabetakis,D. 1912 Wigley,D.B. 2074 Wu,J.R. 3997 Zacharias,W. 1816 Wijnholds,J. 2389 Wu,L. 2120 Zakian,V.A. 1454 Wilcox,E.R. 2565 Wu,Q. 5087 Zamboni,M. 2914 Wilhelm,O. 3887 Wu,Z. 1152 Zandberg,H. 248 Wilk,A. 530 Wuthrich,K. 4827 Zankel,T. 1923 Wilkinson,C.R.M. 203 Wyatt,M.D. 81 Zarytova,V.F. 4400 Will,C. 3260 Xia,L. 4844 Zauberman,A. 2584 Will,K. 4023 Xiao,H. 4799 Zeeman,A.M. 1679 Willemann,B. 3347 Xu,H. 4528 Zelante,L. 4134 Williams,A.S. 654 Xu,J. 2314 Zeltser,R. 4239 Williams,J. 1307 Xu,R. 2314 Zentgraf,H. 3347 Williams,K.L. 2269 Xu,X. 2223,2344 ZevinSonkin,D. 2881 Williams,K.P. 4220 Yagi,N. 2083 Zhang,W. 4620 Williams,K.R. 725 Yakovleva,T. 362 Zhang,W.W. 4073 Williams,R.A.D. 4573 Yamada,Y. 2305 Zhang,X. 1502 Williamson,D.H. 4329 Yamaguchi,S. 20280 Zhang,X.-Y. 3026 Williamson,J.R. 3603 Yamamoto,N. 1445 Zhao,J. 4677 Willison,J.C. 1113 Yamamoto,T. 3351,4664 Zheleznaya,L.A. 1213 Willmitzer,L. 3355 Yamaoka,T. 36 Zhixing,Y. 3353 Wills,Z.P. 1060 Yamashita,T. 357 Zhong,Z. 459 Wilson,D.M.III 5027 Yan,R. 459 Zhou,D.-X. 1165 Wilson,D.N. 1487 Yanagi,H. 4383 Zhou,M. 1089 Wilson,R.J.M. 4329 Yanagisawa,S. 3403 Zhou,S. 4229 Wilson,R.K. 670 Yang,A.S. 1380,4275 Zhou,Y. 475 Wilson,S.H. 1597,3810 Yang,B. 2041 Zhou,Z. 313 Wilusz,J. 1625,2614 Yang,M. 285,1152,2025 Zhu,C. 3872

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