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The Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) Study

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The Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) Study The Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) Study A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid Protocol (UK version) Final V4.0 20 July 2011 EudraCT number: 2007-006658-24 ISRCTN: ISRCTN13704604 CTA reference: 03057/0028/001-0001 REC reference: 08/H1008/174 UKCRN reference: 4611 UKDCTN ID number: UKDCTN0505 Trial Sponsor: University of Nottingham Sponsor’s Reference:RIS 8024 Funding Source: NIHR Health Technology Assessment Programme, Department of Health, United Kingdom (06/403/51) BLISTER Protocol (UK) Page 1 of 49 EudraCT 2007-006658-24 Final v4.0; 20.07.11 This protocol is confidential and the property of the University of Nottingham. No part of it may be transmitted, reproduced, published, or used by others persons without prior written authorisation from the University of Nottingham CONTENTS 1. STUDY PERSONNEL AND CONTACT DETAILS ................................................................................ 4 2. ABBREVIATIONS ...................................................................................................................................... 5 3. SYNOPSIS .................................................................................................................................................... 6 4. STUDY BACKGROUND AND RATIONALE ......................................................................................... 9 4.1. BACKGROUND ....................................................................................................................................... 9 4.2. DETAILS OF INVESTIGATIONAL MEDICINAL PRODUCTS ...................................................................... 10 4.2.1. Description .................................................................................................................................... 10 4.2.2. Packaging and Labelling ............................................................................................................... 10 4.2.3. Storage, dispensing and Return ..................................................................................................... 11 4.2.4. Known Side Effects ........................................................................................................................ 11 5. STUDY PURPOSE AND OBJECTIVES ................................................................................................. 12 5.1. PURPOSE ............................................................................................................................................. 12 5.2. HYPOTHESIS ........................................................................................................................................ 13 5.3. PRIMARY OBJECTIVES ......................................................................................................................... 13 5.4. SECONDARY OBJECTIVES .................................................................................................................... 13 6. STUDY DESIGN ........................................................................................................................................ 13 6.1. OVERVIEW .......................................................................................................................................... 13 6.2. OUTCOME MEASURES ......................................................................................................................... 15 6.2.1. Primary Outcome Measures .......................................................................................................... 15 6.2.2. Secondary Outcome Measures ...................................................................................................... 15 6.2.3. Tertiary Outcome Measures .......................................................................................................... 16 6.3. STOPPING RULES AND DISCONTINUATION .......................................................................................... 16 6.4. RANDOMISATION AND BLINDING ........................................................................................................ 17 6.4.1. Randomisation ............................................................................................................................... 17 6.4.2. Blinding ......................................................................................................................................... 17 6.4.3. Procedures for breaking randomisation code ............................................................................... 18 6.5. TRIAL MANAGEMENT ......................................................................................................................... 18 6.5.1. Trial Co-ordination ....................................................................................................................... 18 6.5.2. Trial Oversight Committees ........................................................................................................... 19 6.6. DURATION OF STUDY AND PARTICIPANT INVOLVEMENT .................................................................... 19 6.6.1. Duration of Participant Involvement in the Study ......................................................................... 19 6.6.2. Duration of the Study ..................................................................................................................... 19 6.6.3. End of the Study ............................................................................................................................. 19 6.7. SELECTION, RECRUITMENT AND WITHDRAWAL OF PARTICIPANTS ..................................................... 19 6.7.1. Participants ................................................................................................................................... 19 6.7.2. Setting ............................................................................................................................................ 20 6.7.3. Recruitment .................................................................................................................................... 20 6.7.4. Inclusion criteria ........................................................................................................................... 20 6.7.5. Exclusion criteria .......................................................................................................................... 21 6.7.6. Retention of participants ............................................................................................................... 21 6.7.7. Withdrawal of participants from treatment and the study ............................................................. 22 6.7.8. Informed consent ........................................................................................................................... 22 6.8. STUDY TREATMENT AND REGIMEN ..................................................................................................... 23 6.8.1. Study Treatment ............................................................................................................................. 23 6.8.2. Rescue Medication ......................................................................................................................... 23 6.8.3. Prohibited Concomitant Medications ............................................................................................ 24 6.8.4. Use of other antibiotics .................................................................................................................. 24 6.8.5. Caution with other concomitant medications ................................................................................ 24 6.8.6. Adherence ...................................................................................................................................... 25 6.8.7. Accountability ................................................................................................................................ 25 6.8.8. Management of study drug overdose ............................................................................................. 25 6.9. STUDY VISIT SCHEDULE AND PROCEDURES ........................................................................................ 25 BLISTER Protocol (UK) Page 2 of 49 EudraCT 2007-006658-24 Final v4.0; 20.07.11 This protocol is confidential and the property of the University of Nottingham. No part of it may be transmitted, reproduced, published, or used by others persons without prior written authorisation from the University of Nottingham 6.9.1. Visit Schedule ................................................................................................................................ 25 6.9.2. Week 0: Baseline visit .................................................................................................................... 28 6.9.3. Week 3 visit .................................................................................................................................... 30 6.9.4. Week 6 visit .................................................................................................................................... 30 6.9.5. Follow up visits at weeks 13, 26, 39 and 52 (open-label phase) ................................................... 31 6.9.6. Extra visits ....................................................................................................................................
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