ASTELLAS US HEADQUARTERS

CORPORATE OVERVIEW HEADQUARTERS FOR THE AMERICAS Astellas Pharma US, Inc ate of -based Astellas Pharma Inc., a top 1 Astellas Way 20 global pharmaceutical research company. Astellas is committed to turning Northbrook, IL 60062-6111 innovative science into medical solutions that bring value and hope to patients EMPLOYEES and their families. Keeping our focus on addressing unmet medical needs and US: 1,150 conducting our business with ethics and integrity enables us to improve the health Americas: 2,800 of people throughout the Americas and around the world. Global:

FY2018 FINANCIAL HIGHLIGHTS (USD) GLOBAL SALES ASTELLAS US SALES R&D INVESTMENT Ticker Symbol $11.7 BILLION $3.8 BILLION $ BILLION 4503

ASTELLAS MILESTONES ASTELLAS US MARKETED PHARMACEUTICAL PRODUCTS IN 2005, FOLLOWING THE MERGER of Yamanouchi & Fujisawa, two of ’s largest and most- respected pharmaceutical companies, Astellas established its U.S. headquarters near Chicago and its Canadian headquarters near Toronto. OH H 2008 N O S

Clinical development N N NH 2009 HQ function moved to the U.S. H 2

Astellas establishes its first

Sao Paulo, Brazil 2010 ® Astellas acquires New York- LEXISCAN 2012 based OSI to support new focus (regadenoson – injection) on Astellas opens new Headquarters for the Americas in INFECTIOUS DISEASE Northbrook, Illinois AMBISOME® ( – lipsome for injection) 2016 2016 CRESEMBA® (isavuconazonium sulfate – capsules and injection) Astellas acquires Ocata Therapeutics, Marlborough, Mass., in Bogota, Colombia, Latin MYCAMINE® and establishes the Astellas Institute America’s third largest country for Regenerative Medicine (micafungin sodium – injection)

2017 2017 ONCOLOGY TARCEVA® Astellas acquires Ogeda SA, Astellas acquires Ganymed Gosselies, Belgium, to expand Pharmaceuticals, Mainz, Germany, ( – tablets) its late stage pipeline to expand its oncology pipeline XTANDI® 2017 2017 (enzalutamide – capsules) XOSPATA® Astellas opens new drug Astellas acquires Mitobridge, discovery and development hub in Cambridge, Mass., to advance San Diego, Calif, Astellas Research and expand developments Institute of America (ARIA) targeting mitochondrial functions TRANSPLANT ASTAGRAF XL® 2018 ( extended-release capsules) PROGRAF® Astellas aquires Quethera, 2018 Cambridge, UK, to further support (tacrolimus – capsules, granules and injection) Astellas' research into new ophthalmic targets, including glaucoma Astellas acquires Universal Cells, Seattle, Wash., to expand innovative cell therapy treatments 2018 MYRBETRIQ® (mirabegron – extended- release tablets) Astellas acquires Potenza Therapeutics, Cambridge, MA, to build a portfolio of ® novel immuno-oncology (IO) therapies VESICARE (solifenacin succinate – tablets)

MEDIA CONTACT | 1-800-888-7704 | [email protected] ASTELLAS OPERATIONS IN THE AMERICAS

Astellas Pharma US, Inc. Headquarters for Astellas US Northbrook, Illinois

Astellas Pharma Global Development, Inc. Northbrook, Illinois Astellas Research Institute of America LLC Policy and Government Affairs San Diego, California Washington, D. C. Astellas Institute for Regenerative Astellas Venture Management LLC Medicine; Universal Cells Menlo Park, California Marlborough, Massachusetts Seattle, Washington Astellas Innovation Management; Mitobridge Astellas Pharma Canada, Inc. Cambridge, Massachusetts Toronto, Ontario Menlo Park, California Astellas Farma Brasil Therapeutics Importacao e Distribuicao de Medicamentos Ltda. Sao Paulo, Brazil

Astellas Farma Colombia Bogotá, Colombia

ASTELLAS US LEADERSHIP

Percival Barretto-Ko Catherine Levitt President, Astellas US Vice President, Regional Legal Astellas US has been recognized as an employer of Head and Secretary choice by Forbes and Working Mother magazines, Joseph Devaney as well as a Great Place to Work in the Pharma Vice President, Policy Chieko Mori and Government Affairs Vice President, Industry and on the Human Rights Campaign’s Corporate Development Corporate Equality Index.

Shontelle Dodson Mark Niemaszek Senior Vice President, Health Vice President, Systems Commercial Operations Walt Johnston Senior Vice President, Mark Reisenauer Sales and Marketing, Urology Senior Vice President, Oncology Astellas has seven dynamic employee resource and Hospital Markets Business Unit groups (ERGs) focused on empowering employees to establish diverse and inclusive Moyra Knight support communities within the organization. Vice President, Corporate Communications and These ERGs include: African American; Asian; President of the Astellas Hispanic; LGBTQ; Military; People Living with Global Health Foundation Disabilities (LEAD); and Stellar Women. BENEFITS STELLAR REWARDS GIVING BACK Astellas’ commitment to changing tomorrow includes operating in a socially responsible way every day, and making Astellas an elite place to work throughout the Americas. We are constantly reviewing our total EMPLOYEES HAVE VOLUNTEERED MORE THAN rewards package to ensure our employees receive valuable and highly competitive benefits and reward opportunities. 110,000 HOURS IN THE AMERICAS

EMPLOYEES AND ASTELLAS HAVE PAY FOR PERFORMANCE Financial Benefits Competitive Pay Retirement DONATED MORE THAN Performance-Driven Merit and 401(k) Savings with Company 1 MILLION Promotional Increases Match and Annual Contribution $ Performance Bonuses Retiree Medical Coverage THROUGH THE COMPANY’S MATCHING GIFTS PROGRAM Long-Term Incentives Financial Wellness Programs Tuition Reimbursement Our commitment to changing tomorrow is WORK /LIFE BALANCE Adoption Assistance measured not only by our focus on bringing Paid Time O Company Paid Life Insurance innovative and e ective new medicines Vacation, Holidays & Sick Time Voluntary Life and Dependent Life to patients and physicians, but also by the Annual Year-end Closure Insurance importance we place on the impact we make within the communities where we work and Volunteer Time O Health Benefits live. Parental School Time O Medical/Prescription Our employees participate and have access to Paid Leaves Dental the following programs as part of our e orts: Maternity/Paternity Leave Vision Changing Tomorrow Day: Throughout Telemedicine Services Bridge Back to Work Program After the year and around the world, our annual Maternity/Paternity Health Advocate Astellas Changing Tomorrow Day events Disability Leave Flexible Spending Account mobilize employees to commit to an entire Family Care Leave Short-Term/Long-Term Disability day of service to local nonprofit organizations Military Leave Wellness Program focused on key areas of need. Onsite Corporate Fitness Center Volunteer Time O Program: Astellas Flexible Work Options in Northbrook provides up to five days paid time o to full- Flexible Work Schedule And more time employees to volunteer for charitable Telecommuting organizations. The Volunteer Time O leave is Voluntary Legal Services Family Care Solutions in addition to holiday or vacation time. Recognition Programs Adult & Parental Care Matching Gifts Program: Astellas will match, Employee Referral Bonus Program Child & Kid Care dollar for dollar, employee contributions Relocation Programs Military Support made to four organizations: American Cancer Matching Gifts Program People Living with Disabilities Society, American Red Cross, Habitat for Humanity and Starlight Children’s Foundation. Employee Assistance Program Executive Benefit Programs (for eligible positions)

MEDIA CONTACT | 1-800-888-7704 | [email protected]