Nano-Solutions for the 21St Century
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Bottom-Up Synthesis and Sensor Applications of Biomimetic Nanostructures
materials Review Bottom-Up Synthesis and Sensor Applications of Biomimetic Nanostructures Li Wang 1,*, Yujing Sun 2, Zhuang Li 2, Aiguo Wu 3 and Gang Wei 4,* Received: 25 November 2015; Accepted: 7 January 2016; Published: 18 January 2016 Academic Editor: Erik Reimhult 1 College of Chemistry, Jilin Normal University, Haifeng Street 1301, Siping 136000, China 2 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, China; [email protected] (Y.S.); [email protected] (Z.L.) 3 Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Material Technology and Engineering, Chinese Academy Sciences, Ningbo 315201, China; [email protected] 4 Faculty of Production Engineering, University of Bremen, Am Fallturm 1, D-28359 Bremen, Germany * Correspondence: [email protected] (L.W.); [email protected] (G.W.); Tel.: +86-139-4441-1011 (L.W.); +49-421-2186-4581 (G.W.) Abstract: The combination of nanotechnology, biology, and bioengineering greatly improved the developments of nanomaterials with unique functions and properties. Biomolecules as the nanoscale building blocks play very important roles for the final formation of functional nanostructures. Many kinds of novel nanostructures have been created by using the bioinspired self-assembly and subsequent binding with various nanoparticles. In this review, we summarized the studies on the fabrications and sensor applications of biomimetic nanostructures. The strategies for creating different bottom-up nanostructures by using biomolecules like DNA, protein, peptide, and virus, as well as microorganisms like bacteria and plant leaf are introduced. -
A Framework for Web Science
Foundations and TrendsR in Web Science Vol. 1, No 1 (2006) 1–130 c 2006 T. Berners-Lee, W. Hall, J.A. Hendler, K. O’Hara, N. Shadbolt and D.J. Weitzner DOI: 10.1561/1800000001 A Framework for Web Science Tim Berners-Lee1, Wendy Hall2, James A. Hendler3, Kieron O’Hara4, Nigel Shadbolt4 and Daniel J. Weitzner5 1 Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology 2 School of Electronics and Computer Science, University of Southampton 3 Department of Computer Science, Rensselaer Polytechnic Institute 4 School of Electronics and Computer Science, University of Southampton 5 Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology Abstract This text sets out a series of approaches to the analysis and synthesis of the World Wide Web, and other web-like information structures. A comprehensive set of research questions is outlined, together with a sub-disciplinary breakdown, emphasising the multi-faceted nature of the Web, and the multi-disciplinary nature of its study and develop- ment. These questions and approaches together set out an agenda for Web Science, the science of decentralised information systems. Web Science is required both as a way to understand the Web, and as a way to focus its development on key communicational and representational requirements. The text surveys central engineering issues, such as the development of the Semantic Web, Web services and P2P. Analytic approaches to discover the Web’s topology, or its graph-like structures, are examined. Finally, the Web as a technology is essentially socially embedded; therefore various issues and requirements for Web use and governance are also reviewed. -
Enantioselective Total Synthesis of (-)-Deoxoapodine
Enantioselective total synthesis of (-)-deoxoapodine The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Kang, Taek, et al., "Enantioselective total synthesis of (-)- deoxoapodine." Angewandte Chemie International Edition 56, 44 (Sept. 2017): p. 13857-60 doi 10.1002/anie.201708088 ©2017 Author(s) As Published 10.1002/anie.201708088 Publisher Wiley Version Author's final manuscript Citable link https://hdl.handle.net/1721.1/125957 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Angew Manuscript Author Chem Int Ed Engl Manuscript Author . Author manuscript; available in PMC 2018 October 23. Published in final edited form as: Angew Chem Int Ed Engl. 2017 October 23; 56(44): 13857–13860. doi:10.1002/anie.201708088. Enantioselective Total Synthesis of (−)-Deoxoapodine Dr. Taek Kang§,a, Dr. Kolby L. White§,a, Tyler J. Mannb, Prof. Dr. Amir H. Hoveydab, and Prof. Dr. Mohammad Movassaghia aDepartment of Chemistry, Massachusetts Institute of Technology Cambridge, MA 02139 (USA) bDepartment of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA) Abstract The first enantioselective total synthesis of (−)-deoxoapodine is described. Our synthesis of this hexacyclic aspidosperma alkaloid includes an efficient molybdenum-catalyzed enantioselective ring-closing metathesis reaction for desymmetrization of an advanced intermediate that introduces the C5-quaternary stereocenter. After C21-oxygenation, the pentacyclic core was accessed via an electrophilic C19-amide activation and transannular spirocyclization. A biogenetically inspired dehydrative C6-etherification reaction proved highly effective to secure the F-ring and the fourth contiguous stereocenter of (−)-deoxoapodine with complete stereochemical control. -
Breakthrough Technologies
21ST INTERNATIONAL CONFERENCE ON ENGINEERING DESIGN, ICED17 21-25 AUGUST 2017, THE UNIVERSITY OF BRITISH COLUMBIA, VANCOUVER, CANADA BREAKTHROUGH TECHNOLOGIES: PRINCIPLE FEASIBILITY DEBATES Hein, Andreas Makoto (1); Jankovic, Marija (1); Condat, Hélène (2) 1: CentraleSupélec, Université Paris Saclay, France; 2: Initiative for Interstellar Studies, United Kingdom Abstract Designing new technologies involves creating something that did not exist before. In particular, designing technologies with a low degree of maturity usually involves an assessment of its feasibility or infeasibility. Assessing the feasibility of a technology is of vital importance in many domains such as technology management and policy. Despite its importance, few publications actually deal with the fundamentals of technological feasibility such as feasibility proofs or proposing different feasibility categories. This paper addresses this gap by reviewing the existing literature on the feasibility of low- maturity technologies, proposes a framework for assessing feasibility issues, and reconstructs past and ongoing feasibility debates of four exemplary technologies. For the four technologies analysed, we conclude that sufficient expected performance is a key feasibility criteria to all cases, whereas physical effects and working principles were issues for more speculative technologies. For future work, we propose the further development of feasibility categories for different technologies of different degrees of maturity. Keywords: Systems Engineering (SE), Technology, Conceptual design, Early design phases, Uncertainty Contact: Andreas Makoto Hein CentraleSupélec, Université Paris-Saclay Laboratoire Génie Industriel France [email protected] Please cite this paper as: Surnames, Initials: Title of paper. In: Proceedings of the 21st International Conference on Engineering Design (ICED17), Vol. 2: Design Processes | Design Organisation and Management, Vancouver, Canada, 21.-25.08.2017. -
Biomimetic Total Synthesis of Natural Products
Biomimetic Total Synthesis of Natural Products Thesis submitted for the degree of Doctor of Philosophy Hiu Chun Lam Bsc (Hons.) Chemistry Department of Chemistry University of Adelaide Aug, 2017 To my family II Declaration I certify that this work contains no material which has been accepted for the award of any other degree or diploma in my name, in any university or other tertiary institution and, to the best of my knowledge and belief, contains no material previously published or written by another person, except where due reference has been made in the text. In addition, I certify that no part of this work will, in the future, be used in a submission in my name, for any other degree or diploma in any university or other tertiary institution without the prior approval of the University of Adelaide and where applicable, any partner institution responsible for the joint-award of this degree. I give consent to this copy of my thesis, when deposited in the University Library, being made available for loan and photocopying, subject to the provisions of the Copyright Act 1968. I also give permission for the digital version of my thesis to be made available on the web, via the University’s digital research repository, the Library Search and also through web search engines, unless permission has been granted by the University to restrict access for a period of time. I acknowledge the support I have received for my research through the provision of an Australian Government Research Training Program Scholarship Hiu Chun Lam Date III Acknowledgements First, I would like to thank my supervisor Dr. -
Posttranslational Chemical Installation of Azoles Into Translated Peptides ✉ ✉ Haruka Tsutsumi1,2, Tomohiro Kuroda1,2, Hiroyuki Kimura 1, Yuki Goto 1 & Hiroaki Suga 1
ARTICLE https://doi.org/10.1038/s41467-021-20992-0 OPEN Posttranslational chemical installation of azoles into translated peptides ✉ ✉ Haruka Tsutsumi1,2, Tomohiro Kuroda1,2, Hiroyuki Kimura 1, Yuki Goto 1 & Hiroaki Suga 1 Azoles are five-membered heterocycles often found in the backbones of peptidic natural products and synthetic peptidomimetics. Here, we report a method of ribosomal synthesis of azole-containing peptides involving specific ribosomal incorporation of a bromovinylglycine 1234567890():,; derivative into the nascent peptide chain and its chemoselective conversion to a unique azole structure. The chemoselective conversion was achieved by posttranslational dehydro- bromination of the bromovinyl group and isomerization in aqueous media under fairly mild conditions. This method enables us to install exotic azole groups, oxazole and thiazole, at designated positions in the peptide chain with both linear and macrocyclic scaffolds and thereby expand the repertoire of building blocks in the mRNA-templated synthesis of designer peptides. 1 Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, Japan. 2These authors contributed equally: Haruka Tsutsumi, ✉ Tomohiro Kuroda. email: [email protected]; [email protected] NATURE COMMUNICATIONS | (2021) 12:696 | https://doi.org/10.1038/s41467-021-20992-0 | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-021-20992-0 zoles, such as oxazoles and thiazoles, are five-membered heterocycles often found in the backbone of peptidic UCAG DNA template U A 1,2 Phe Tyr Cys C natural products . Such azole-containing natural pep- U Ser O Leu A tides exhibit a variety of bioactivities, including antitumor, anti- Trp G – His U H2N 3 9 C Leu Pro Arg C OH fungal, antibiotic, and antiviral activities . -
Hanover Middle School
Hanover Middle School Program of Studies Revised Spring 2018 Hanover Middle School Principal Daniel Birolini Assistant Principal Joel Barrett Assistant Principal Anna Hughes Special Education Administrator Bernard McNamara Superintendent Matthew A. Ferron Assistant Superintendent Debbie St. Ives Director of Student Services Keith Guyette Business Manager Dr. Thomas R. Raab School Committee Leah Miller, Chairperson Kim Mills-Booker, Vice Chairperson Elizabeth Corbo John Geary Ruth Lynch 1 Working Draft 2 Working Draft Mission Statement The mission of Hanover Middle School is to establish a safe learning environment that fosters respect, responsibility, perseverance, and support for all learners. General Expectations The Hanover Middle School Student: 1. Reads actively and critically 2. Writes effectively to construct and convey meaning 3. Listens attentively and speaks effectively 4. Applies concepts to interpret information, to solve problems, and to justify solutions 5. Respects and honors school policies Message From The Administration On behalf of the Administration, Faculty, and Staff of the Hanover Middle School, I am excited to share the Program of Studies for the 2018-2019 school year. The Middle School faculty is pleased to present a comprehensive program of studies that highlights the many different educational experiences offered to our students. We are confident that when our students leave Hanover Middle School, each one has been able to take advantage of a variety of opportunities that have allowed them to not only grow, but excel, in their academics. In addition, we offer a number of unique experiences that extend and enrich students beyond the classroom environment. After their years at Hanover Middle School, they are well prepared for high school and beyond. -
Exploratory Engineering in AI
MIRI MACHINE INTELLIGENCE RESEARCH INSTITUTE Exploratory Engineering in AI Luke Muehlhauser Machine Intelligence Research Institute Bill Hibbard University of Wisconsin Madison Space Science and Engineering Center Muehlhauser, Luke and Bill Hibbard. 2013. “Exploratory Engineering in AI” Communications of the ACM, Vol. 57 No. 9, Pages 32–34. doi:10.1145/2644257 This version contains minor changes. Luke Muehlhauser, Bill Hibbard We regularly see examples of new artificial intelligence (AI) capabilities. Google’s self- driving car has safely traversed thousands of miles. Watson beat the Jeopardy! cham- pions, and Deep Blue beat the chess champion. Boston Dynamics’ Big Dog can walk over uneven terrain and right itself when it falls over. From many angles, software can recognize faces as well as people can. As their capabilities improve, AI systems will become increasingly independent of humans. We will be no more able to monitor their decisions than we are now able to check all the math done by today’s computers. No doubt such automation will produce tremendous economic value, but will we be able to trust these advanced autonomous systems with so much capability? For example, consider the autonomous trading programs which lost Knight Capital $440 million (pre-tax) on August 1st, 2012, requiring the firm to quickly raise $400 mil- lion to avoid bankruptcy (Valetkevitch and Mikolajczak 2012). This event undermines a common view that AI systems cannot cause much harm because they will only ever be tools of human masters. Autonomous trading programs make millions of trading decisions per day, and they were given sufficient capability to nearly bankrupt one of the largest traders in U.S. -
2018-2019 Valley STEM + ME2 Academy-Coursework
2018-2019 Valley STEM + ME2 Academy-Coursework Mission: To prepare students with skills necessary to compete in the global economy while nurturing the characteristics of discovery, invention, application, and entrepreneurship. The curriculum in Valley STEM + ME2 Academy was chosen to guide students in the mission of the program. Data from the current job market, student interests, and college/career readiness guides curriculum choices. Valley STEM + ME2 incorporates STEM Principles as the foundation for the curriculum. Advanced Career/Clean Energy Technology will be taught throughout the program. Specific course sequencing is below. Freshmen Coursework 2018-2019 (descriptions below) ● FANUC/Motoman (RAMTEC Lab ) ○ Students may have opportunity to earn 12-points in Industry Credentials ● Clean Energy Technology 1 & 2 ○ Clean Energy Technology 1 & 2 Course Description ● Robotics 1 with Computer Programming ○ Utilizing Start Up Tech Curriculum that incorporates Entrepreneurship and App Development ● Exploratory Engineering ● 21st Century Communications ● English Language Arts 9, or English Language Arts 9 Honors ● Math ○ Course depends on 8th grade math credit; per Ohio Department of Education Graduation Requirements) ● World History or Honors World History ● Biology or Honors Biology ● PE and Health: Taken online semester 2, unless transcripted credit given at the middle school level per ODE Graduation Requirements (½ unit Health, ½ unit PE). Students have the option to take summer school prior to attending, or take the online coursework -
UNIVERSITY of CALIFORNIA Los Angeles Biomimetic Synthesis Of
UNIVERSITY OF CALIFORNIA Los Angeles Biomimetic Synthesis of Noble Metal Nanoparticles and Their Applications as Electro-catalysts in Fuel Cells A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Materials Science and Engineering by Yujing Li 2012. © Copyright by Yujing Li 2012 ABSTRACT OF THE DISSERTATION Biomimetic Synthesis of Noble Metal Nanoparticles and Their Applications as Electro-catalysts in Fuel Cells by Yujing Li Doctor of Philosophy in Materials Science and Engineering University of California, Los Angeles, 2012 Professor Yu Huang, Chair Today, proton electrolyte membrane fuel cell (PEMFC) and direct methanol fuel cell (DMFC) are attractive power conversion devices that generate fairly low or even no pollution, and considered to be potential to replace conventional fossil fuel based power sources on automobiles. The operation and performance of PEMFC and DMFC depend largely on electro-catalysts positioned between the electrode and the membranes. The most commonly used electro-catalysts for PEMFC and DMFC are Pt-based noble metal nanoparticles, so catalysts share close to 50% of the total cost of the fuel cell. The synthesis of such nanoscale electro-catalysts are commonly limited to harsh conditions (high temperature, high pressure), organic solvent, high amount of stabilizing agent, to achieve the size and morphological control. There is no rational guideline for the ii selection of stabilizing agent for specific materials, leading to the current "trial and error" -
Utility Value of an Introductory Engineering Design Course: an Evaluation Among Course Participants
Paper ID #30527 Utility value of an introductory engineering design course: an evaluation among course participants. Dr. Lilianny Virguez, University of Florida Lilianny Virguez is a Lecturer at the Engineering Education Department at University of Florida. She holds a Masters’ degree in Management Systems Engineering and a Ph.D. in Engineering Education from Virginia Tech. She has work experience in telecommunications engineering and has taught undergraduate engineering courses such as engineering design at the first-year level and elements of electrical engi- neering. Her research interests include motivation to succeed in engineering with a focus on first-year students. Dr. Pamela L Dickrell, University of Florida Dr. Pamela Dickrell is the Associate Chair of Academics of the Department of Engineering Education, in the UF Herbert Wertheim College of Engineering. Her research focuses on effective teaching methods and hands-on learning opportunities for undergraduate student engagement and retention. Dr. Dickrell received her B.S., M.S., and Ph.D. in Mechanical Engineering from the University of Florida, specializing in Tribology. Andrea Goncher, University of Florida Andrea Goncher is a Lecturer in Engineering Education at the University of Florida. She earned her PhD in Engineering Education from Virginia Tech and focuses on teaching and learning projects in human cen- tred design. Her research interests include text analytics, international higher education, and engineering design education. c American Society for Engineering Education, 2020 Utility value of an introductory engineering design course: an evaluation among course participants. Abstract This paper describes an assessment of the implementation of an engineering design class by exploring how valuable students perceive the course in subsequent years in their college experience. -
A Mineralogical View of Apatitic Biomaterials
1 1 2 Revision 1 3 MS #5732R 4 5 6 7 8 9 10 11 A Mineralogical View of Apatitic Biomaterials 12 13 14 Jill Dill Pasteris 15 Department of Earth and Planetary Sciences and 16 Institute for Materials Science and Engineering 17 Washington University in St. Louis 18 St. Louis, MO 63130-4899 19 20 [email protected] 21 22 23 24 25 26 27 28 29 30 Revised version submitted to American Mineralogist 31 July 6, 2016 32 33 34 35 36 37 38 39 40 41 2 42 Abstract 43 44 Biomaterials are synthetic compounds and composites that replace or assist missing or 45 damaged tissue or organs. This review paper addresses calcium phosphate biomaterials that are 46 used as aids to or substitutes for bones and teeth. The viewpoint taken is that of mineralogists 47 and geochemists interested in (carbonated) hydroxylapatite, its range of compositions, the 48 conditions under which it can be synthesized, and how it is used as a biomaterial either alone or 49 in a composite. Somewhat counterintuitively, the goal of most medical or materials science 50 researchers in this field is to emulate the properties of bone and tooth, rather than the 51 hierarchically complex materials themselves. The absence of a directive to mimic biological 52 reality has permitted the development of a remarkable range of approaches to apatite synthesis 53 and post-synthesis processing. Multiple means of synthesis are described from low-temperature 54 aqueous precipitation, sol gel processes, and mechanosynthesis to high-temperature solid-state 55 reactions and sintering up to 1000 °C.