Canagliflozin and Renal Outcomes in Type 2 Diabetes: Data From the CANVAS Randomised Clinical Trial Program Vlado Perkovic, MBBS, PhD1,2; Dick de Zeeuw, MD, PhD3; Kenneth W. Mahaffey, MD4; Greg Fulcher, MD2; Ngozi Erondu, MD, PhD5; Wayne Shaw, DSL5; Terrance D. Barrett, PhD5; Michele Weidner-Wells, PhD5; Hsiaowei Deng, ScM5; David R. Matthews, BM, BCh, DPhil6; Bruce Neal, MB ChB, PhD1,7-9 1The George Institute for Global Health, UNSW Sydney, Sydney, Australia; 2The Royal North Shore Hospital and University of Sydney, Sydney, Australia; 3University of Groningen, University Medical Center Groningen, The Netherlands; 4Stanford Center for Clinical Research (SCCR), Stanford University, Department of Medicine, Stanford, CA, USA; 5Janssen Research & Development, LLC, Raritan, NJ, USA; 6University of Oxford, Oxford, UK; 7The Charles Perkins Centre, University of Sydney, Australia; 8Royal Prince Alfred Hospital, Sydney, Australia; 9Imperial College London, London, UK. Corresponding author: Vlado Perkovic, MBBS, PhD The George Institute for Global Health Level 5, 1 King St Newtown, NSW 2042 Australia Tel: +61 2 8052 4418 Fax: +61 2 9012 0747 Email:
[email protected] Perkovic CANVAS Program renal manuscript resubmission JGL-62615 resubmission.docx; 3/16/18 Word count: 4233/4500 words Figures/tables: 4 figures and 1 table 2 Perkovic CANVAS Program renal manuscript resubmission JGL-62615 resubmission.docx; 3/16/18 Research in Context Evidence before this study Sodium glucose co-transporter 2 (SGLT2) inhibitors such as canagliflozin reduce