APPENDIX Trial Steering Committee Data Safety Monitoring Board

Total Page：16

File Type：pdf, Size：1020Kb

APPENDIX Trial Steering Committee Data Safety Monitoring Board

APPENDIX Trial Steering Committee Nigel D Toussaint (Chair), Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia; Eugenia Pedagogos, Epworth Healthcare, Melbourne, Australia; Carmel M Hawley, Princess Alexandra Hospital, Brisbane, Australia; Grahame J Elder, Westmead Hospital, Westmead, Australia; Elaine M Pascoe, Australasian Kidney Trials Network, Brisbane, Australia; Sunil V Badve, St. George Hospital, Sydney, Australia; Geoffrey A Block, Colorado Kidney Care, Denver, United States; Neil C Boudville, Sir Charles Gairdner Hospital, Perth, Australia; Katrina Campbell, Princess Alexandra Hospital, Brisbane, Australia; James D Cameron, Monash Heart, Monash University, Clayton, Australia; Sylvia Chen, Epworth Healthcare, Melbourne, Australia; Randall J Faull, Royal Adelaide Hospital, Adelaide, Australia; Stephen G Holt, The Royal Melbourne Hospital, Parkville, Australia; Lai S Hooi, Sultanah Aminah Hospital, Johor Bahru, Malaysia; Meg J Jardine, The George Institute for Global Health, Sydney, Australia; Peter G Kerr, Monash Medical Centre, Clayton, Australia; Kenneth K Lau, Monash Medical Centre, Clayton, Australia; Vlado Perkovic, The George Institute for Global Health, Sydney, Australia; Kevan R Polkinghorne, Monash Medical Centre, Clayton, Australia; Carol A Pollock, Royal North Shore Hospital, Sydney, Australia; Donna Reidlinger, Australasian Kidney Trials Network, Brisbane, Australia; Edward R Smith, The Royal Melbourne Hospital, Parkville, Australia; Robert J Walker, Dunedin Hospital, Dunedin, New Zealand; Angela Yee Moon Wang, Queen Mary Hospital, University of Hong Kong, Hong Kong. Data Safety Monitoring Board Bruce C Neal (Chair), Deputy Executive Director, The George Institute for Global Health, and Professor of Medicine, University of New South Wales, Sydney, Australia; Andrew B Forbes, Department of Epidemiology and Preventive Medicine, Monash University, Clayton, Australia; Christoph Wanner, Division of Nephrology and Hypertension, University Hospital of Würzburg, Germany; and David C Wheeler, Centre for Nephrology, Royal Free and University College Medical School, London, the United Kingdom. Australasian Kidney Trials Network Australasian Kidney Trials Network (AKTN), Brisbane, Queensland, Australia Operational Team Carmel M Hawley (Chair, AKTN Operations Secretariat), David W Johnson (Deputy Chair, AKTN Operations Secretariat), Sunil V Badve, Yeong Jee Cho, Darsy Darssan, Magid Fahim, Rathika Krishnasamy, Alicia Morrish, Elaine M Pascoe, Peta-Anne Paul-Brent, Donna Reidlinger, Laura Robison, Anish Scaria, Andrea Valks, Liza Vergara. Executive Committee Carmel M Hawley (Chair), David W Johnson (Deputy Chair), Sunil V Badve, Neil C Boudville, Alan Cass, Meg J Jardine, Alicia Morrish, Elaine M Pascoe, Vlado Perkovic, Donna Reidlinger. .

Copy Link

Recommended publications

Our Mission Is to Improve the Health of Millions of People Worldwide
Our mission is to improve the health of millions of people worldwide The George Institute for Global Health 2014–15 Annual Report “I am The George because I’m passionate about healthcare research.” Mohammed Alim, Research Fellow, The George Institute, India The George Institute for Global Health ABN 90 085 953 331. We are a registered charity in Australia and the United Kingdom. George Clinical Pty Ltd ABN 33 098 184 528. All amounts are in Australian dollars unless otherwise indicated. Annual Report Production Team: E. Richard Mills, Director, Global Communications and Advocacy. Maya Kay, Communications Manager Australia. Chelsea Hunnisett, Communications & Events Coordinator, Australia Communications. Alexander Baldock, Design Manager, Global Communications and Advocacy. The George Institute for Global Health 2 2014-15 Annual Report Who we are Established in 1999, The George Institute for Global Health is a global, not-for-profi t medical research organisation, affi liated with leading academic partners, with major centres in Australia, China, India and the United Kingdom. We have been ranked among the top 10 research institutions in the world for scientifi c impact by the SCImago Institutions Rankings (SIR) World Reports in 2011, 2012, 2013 & 2014. Our mission Our Mission is to improve the health of millions of people worldwide. Our VALUES Our humanitarian commitment Our focus on excellence will Our integrity will underpin all our will spur us to tackle the health produce scientifi c evidence work and interactions, including issues affecting high-risk and that is ethical and of the our collaborations with partner disadvantaged people worldwide. highest quality. organisations worldwide.
[Show full text]
Chronic Kidney Disease, Cardiovascular Events, and the Effects of Perindopril-Based Blood Pressure Lowering: Data from the PROGRESS Study
CLINICAL RESEARCH www.jasn.org Chronic Kidney Disease, Cardiovascular Events, and the Effects of Perindopril-Based Blood Pressure Lowering: Data from the PROGRESS Study Vlado Perkovic,*† Toshiharu Ninomiya,* Hisatomi Arima,* Martin Gallagher,* Meg Jardine,* Alan Cass,*‡ Bruce Neal,* Stephen MacMahon,*‡ and John Chalmers*‡ *George Institute for International Health, University of Sydney, †Royal North Shore Hospital, and ‡Royal Prince Alfred Hospital, Sydney, Australia ABSTRACT Chronic kidney disease (CKD) is associated with a high risk of cardiovascular disease, but evidence regarding the effectiveness of interventions to reduce that risk is lacking. The Perindopril Protection against Recurrent Stroke Study (PROGRESS) study enrolled 6105 participants with cerebrovascular disease and randomly allocated them to perindopril-based blood pressure–lowering therapy or placebo. Individuals with CKD were at approximately 1.5-fold greater risk of major vascular events, stroke, and coronary heart disease, and were more than twice as likely to die (all PՅ0.002). Perindopril-based treatment reduced the risk of major vascular events by 30% and stroke by 35% among subjects with CKD, and the absolute effects of treatment were 1.7-fold greater for those with CKD than for those without. Considering patients with CKD and a history of cerebrovascular disease, perindopril prevented one stroke or other cardiovascular event among every 11 patients treated over five years. In conclusion, kidney function should be considered when determining the need for blood pressure lowering therapy in patients with cerebrovascular disease. J Am Soc Nephrol 18: 2766–2772, 2007. doi: 10.1681/ASN.2007020256 Chronic kidney disease (CKD) is being increasingly monly elevated in people with CKD, raising the recognized as a leading public health problem.
[Show full text]
Effects of Fibrates in Kidney Disease a Systematic Review and Meta-Analysis
Journal of the American College of Cardiology Vol. 60, No. 20, 2012 © 2012 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. http://dx.doi.org/10.1016/j.jacc.2012.07.049 Effects of Fibrates in Kidney Disease A Systematic Review and Meta-Analysis Min Jun, BSC(HONS), MSC(CLINEPI),* Bin Zhu, MD, PHD,† Marcello Tonelli, MD, PHD,‡ Meg J. Jardine, MBBS, PHD,* Anushka Patel, MBBS, PHD,* Bruce Neal, MB, CHB, PHD,* Thaminda Liyanage, MBBS,§ Anthony Keech, MBBS, MSC (EPID),ʈ Alan Cass, MBBS, PHD,* Vlado Perkovic, MBBS, PHD* Sydney, Australia; Hangzhou, China; and Edmonton, Alberta, Canada Objectives The purpose of this systematic review and meta-analysis was to determine the efficacy and safety of fibrate therapy in the chronic kidney disease (CKD) population. Background Fibrate therapy produces modest cardiovascular benefits in people at elevated cardiovascular risk. There is lim- ited evidence about the clinical benefits and safety of fibrate therapy in the CKD population. Methods MEDLINE, EMBASE, and the Cochrane Library were systematically searched (1950 to January 2012) for prospec- tive randomized controlled trials assessing the effects of fibrate therapy compared with placebo in people with CKD or on kidney-related outcomes were included. Results Ten studies including 16,869 participants were identified. In patients with mild-to-moderate CKD (estimated glo- merular filtration rate [eGFR] Յ60 ml/min/1.73 m2), fibrates improved lipid profiles (lowered total cholesterol [Ϫ0.32 mmol/l, p ϭ 0.05] and triglyceride levels [Ϫ0.56 mmol/l, p ϭ 0.03] but not low-density lipoprotein cho- lesterol [Ϫ0.01 mmol/l, p ϭ 0.83]; increased high-density lipoprotein cholesterol [0.06 mmol/l, p ϭ 0.001]).
[Show full text]
HREC Web.Pdf
Hospital Name Principal Project No. Approving HREC Contact Phone Email Investigator HREC Person (for complaints or concerns) Alfred Hospital Dr Stephen Duffy 47/12 Alfred Hospital Ethics Ms Emily Bingle 03 9076 3619 [email protected] Committee Austin Hospital Dr David Clark H2012/04647 Austin Hospital HREC Ms Sianna 03 9496 5088 [email protected] Panagiotopoulos Ballarat Hospital Dr Ernesto Oqueli HREC/12/BHSSJOG/ Ballarat Health Dr Susan Joy Shea 03 5320 4787 [email protected] 63 Services HREC Bairnsdale Regional Dr Ka Chun Tse 2013-06 Latrobe Regional Patient Liaison Manager 03 5173 8003 [email protected] Health Services Hospital HREC Bendigo Health Dr Voltaire HREC/12/BHCG/23 Bendigo Healthcare HREC Chairperson 03 5454 6412 [email protected] Nadurata Group HREC (Sally McCarthy) Box Hill Hospital A/Prof Gishel New E09/1213 Eastern Health HREC HREC Chairperson 03 9895 3398 [email protected] Cabrini Dr Jeffrey 05-10-09-12 Cabrini HREC Anne Spence 03 9508 1376 [email protected] Lefkovits Epworth Healthcare Dr Ron Dick 55912 Epworth Healthcare HREC Coordinator 03 9426 8806 [email protected] Richmond HREC Epworth Healthcare Dr Ron Dick 55912 Epworth Healthcare HREC Coordinator 03 9426 8806 [email protected] Eastern HREC Frankston Hospital Dr Geoff Toogood HREC/12/PH/42 Peninsula Health HREC The Convenor 03 9788 1473 [email protected] Geelong Private Hospital A/Prof John CF12/1018- Monash HREC Executive Officer [email protected] Amerina 2012000481 03 9905 2052 Gippsland Base Hospital
[Show full text]
Annual Report 2019 Connected Care 15
Every patient matters and we are committed to providing high-quality patient care, delivered by a skilled, dedicated, compassionate workforce. We continue to innovate and find new ways of caring, in line with community need. Continually improving our patients’ experience, on each and every touchpoint of their journey with us, is always our goal. Epworth HealthCare is Victoria’s largest not-for-profit private hospital group, renowned for excellence in diagnosis, treatment, care and rehabilitation. Epworth is an innovator in Australia’s health system, embracing the latest in evidence-based medicine to pioneer treatments and services for our patients. Our vision: Caring for people. Innovating for a healthy community. Our purpose: Every patient matters. We strive to improve health outcomes and experience through compassion, collaboration, learning and innovation. Our values: Respect, excellence, community, compassion, integrity, accountability. Epworth was founded in 1920 as a 25-bed community intermediate hospital in Richmond by a Methodist minister for those on moderate incomes. We will celebrate our centenary next year. Today, our care is world-class, our technology is state- of-the-art and our ethos remains focused on our patients. This Annual Report details achievements and highlights of the 2018–19 financial year. It follows the pillars of our Strategic Plan: Connected Care, Empowered People, Innovative Practice and Sustainability. This report is available online at epworth.org.au We also highlight some of our patient stories - as patients are at the heart of all we do. Acknowledgement of Country Epworth HealthCare acknowledges the people of the Kulin Nations, on whose land we work and care for our patients.
[Show full text]
Lancet Commission
Lancet Commission Global Kidney Health 2017 and beyond: A roadmap for closing gaps in care, research, and policy Adeera Levin MD,* Marcello Tonelli MD,* (co first authorship shared) University of British Columbia, University of Calgary *co-chairs of the ISN Global Kidney Health Summit on behalf of the International Society of Nephrology Joseph Bonventre MD, Brigham and Women’s Hospital, Harvard Medical School, Massachusetts Institute of Technology Josef Coresh MD, George W. Comstock Center for Public Health Research and Prevention, Welch Center for Prevention, Epidemiology and Clinical Research Jo-Ann Donner, International Society of Nephrology Agnes B. Fogo MD, Vanderbilt University Medical Center Caroline Fox MD, Merck Research Labs, Brigham and Women’s Hospital Ron Gansevoort MD, University Medical Center Groningen Meg Jardine MD, The George Institute for Global Health, The University of Sydney Bert Kasiske MD, Hennepin County Medical Center, University of Minnesota Anna Köttgen MD, Medical Center - University of Freiburg, Johns Hopkins Bloomberg School of Public Health Matthias Kretzler MD, University of Michigan Hiddo JL Heerspink PhD, University Medical Center Groningen Andrew S. Levey MD, Tufts Medical Center, Tufts University School of Medicine Valerie Luyckx MD, University of Zurich, Brigham and Women’s Hospital Ravindra Mehta MD, University of California San Diego Orson Moe MD, University of Texas Southwestern Medical Center Gregorio Obrador MD, Universidad Panamericana School of Medicine Neesh Pannu MD, University of Alberta Chirag Parikh MD, Yale University, Veteran’s Administration Connecticut Healthcare System Vlado Perkovic MD, George Institute for Global Health, University of Sydney, Royal North Shore Hospital Carol Pollock MD, University of Sydney, Royal North Shore Hospital Peter Stenvinkel MD, Karolinska Institutet Katherine Tuttle MD, Providence Health Care, University of Washington David C.
[Show full text]
Effects of Linagliptin on Cardiovascular and Kidney
EMERGING THERAPIES: DRUGS AND REGIMENS Diabetes Care 1 Vlado Perkovic,1 Robert Toto,2 Mark E. Cooper,3 Effects of Linagliptin on Johannes F.E. Mann,4,5 Julio Rosenstock,6 Darren K. McGuire,2 Steven E. Kahn,7 Cardiovascular and Kidney Nikolaus Marx,8 John H. Alexander,9 Bernard Zinman,10,11 Egon Pfarr,12 Outcomes in People With Normal Sven Schnaidt,13 Thomas Meinicke,13 Maximillian von Eynatten,12 Jyothis T. George,12 and Reduced Kidney Function: Odd Erik Johansen,14 and Christoph Wanner,15 Secondary Analysis of the on behalf of the CARMELINA investigators CARMELINA Randomized Trial https://doi.org/10.2337/dc20-0279 1Faculty of Medicine, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia 2University of Texas Southwestern Medical Cen- ter, Dallas, TX 3Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia 4Kuratorium fur¨ Dialyse Kidney Centre, Munich, Germany 5 OBJECTIVE Department of Nephrology, Friedrich-Alexander University of Erlangen-Nurnberg,¨ Erlangen, Germany Type 2 diabetes is a leading cause of kidney failure, but few outcome trials 6Dallas Diabetes Research Center, Dallas, TX proactively enrolled individuals with chronic kidney disease (CKD). We performed 7Division of Metabolism, Endocrinology and Nu- secondary analyses of cardiovascular (CV) and kidney outcomes across baseline trition, Department of Medicine, VA Puget Sound ﬁ ‡ < < Health Care System and University of Washing- estimated glomerular ltration rate (eGFR) categories ( 60, 45 to 60, 30 to 45, ton, Seattle, WA 2 and <30 mL/min/1.73 m ) in Cardiovascular and Renal Microvascular Outcome 8Department of Internal Medicine I, University Study With Linagliptin (CARMELINA), a cardiorenal placebo-controlled outcome Hospital Aachen, RWTH Aachen University, Aa- trial of the dipeptidyl peptidase 4 inhibitor linagliptin (NCT01897532).
[Show full text]
Research Priorities in Chronic Kidney Disease for Australia: Report of a Conference
Title: Research priorities in chronic kidney disease for Australia: Report of a conference Authors first and last names and highest degree: Allison Tong, PhD1,2 Sally Crowe, PG Dip3 Shingisai Chando, MPH1,2 Alan Cass, PhD4 Steve J Chadban, PhD5 Jeremy R Chapman, FRCP6 Martin Gallagher, PhD1,7,8 Carmel M Hawley, MBBS9,10,11 Sophie Hill, PhD12 Kirsten Howard, PhD1 David W Johnson, PhD9,10,11 Peter G Kerr, PhD13 Anne McKenzie14 David Parker13 Vlado Perkovic, PhD8 Kevan R Polkinghorne, PhD12 Carol Pollock, PhD1,15 Giovanni FM Strippoli, PhD1,16,17,18 Peter Tugwell, FRCP19 Rowan G Walker, PhD20 Angela C Webster, PhD1,2,6 Germaine Wong, PhD1,2,6 Jonathan C Craig PhD1,2 for the CEPORT COLLABORATION Institution of each author: 1Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia 2Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia 3Crowe Associates Ltd, Oxon, United Kingdom 4Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia 5Royal Prince Alfred Hospital, Sydney, New South Wales, Australia 6Centre for Transplant and Renal Research, Westmead Hospital, Sydney, New South Wales, Australia 7Department of Nephrology, Concord Hospital, Sydney, New South Wales, Australia 8Renal and Metabolic Division, The George Institute, Sydney, New South Wales, Australia 9Queesland School of Medicine, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia 10Translational Research Institute, Brisbane, Australia
[Show full text]
Postgraduate Medical Council of Victoria Inc. Health
POSTGRADUATE MEDICAL COUNCIL OF VICTORIA INC. CONTENTS Albury Wodonga Health .......................................................................................................................... 5 Alexandra District Health / Eastern Health Collaborative ...................................................................... 5 Alfred Health ........................................................................................................................................... 6 Austin Health........................................................................................................................................... 6 Austin Health – COMBINED NURSING / MENTAL HEALTH .................................................................... 7 Bairnsdale Regional Health Service......................................................................................................... 7 Ballarat Health Services .......................................................................................................................... 8 Ballarat Health Services – Care of the Older Person (COOPS) ................................................................ 8 Barwon Health ........................................................................................................................................ 9 Barwon Health & Great Ocean Road Health Collaborative .................................................................... 9 Bass Coast Health .................................................................................................................................
[Show full text]
Canagliflozin and Renal Outcomes in Type 2 Diabetes: Data from the CANVAS Randomised Clinical Trial Program Vlado Perkovic, MBBS
Canagliflozin and Renal Outcomes in Type 2 Diabetes: Data From the CANVAS Randomised Clinical Trial Program Vlado Perkovic, MBBS, PhD1,2; Dick de Zeeuw, MD, PhD3; Kenneth W. Mahaffey, MD4; Greg Fulcher, MD2; Ngozi Erondu, MD, PhD5; Wayne Shaw, DSL5; Terrance D. Barrett, PhD5; Michele Weidner-Wells, PhD5; Hsiaowei Deng, ScM5; David R. Matthews, BM, BCh, DPhil6; Bruce Neal, MB ChB, PhD1,7-9 1The George Institute for Global Health, UNSW Sydney, Sydney, Australia; 2The Royal North Shore Hospital and University of Sydney, Sydney, Australia; 3University of Groningen, University Medical Center Groningen, The Netherlands; 4Stanford Center for Clinical Research (SCCR), Stanford University, Department of Medicine, Stanford, CA, USA; 5Janssen Research & Development, LLC, Raritan, NJ, USA; 6University of Oxford, Oxford, UK; 7The Charles Perkins Centre, University of Sydney, Australia; 8Royal Prince Alfred Hospital, Sydney, Australia; 9Imperial College London, London, UK. Corresponding author: Vlado Perkovic, MBBS, PhD The George Institute for Global Health Level 5, 1 King St Newtown, NSW 2042 Australia Tel: +61 2 8052 4418 Fax: +61 2 9012 0747 Email: [email protected] Perkovic CANVAS Program renal manuscript resubmission JGL-62615 resubmission.docx; 3/16/18 Word count: 4233/4500 words Figures/tables: 4 figures and 1 table 2 Perkovic CANVAS Program renal manuscript resubmission JGL-62615 resubmission.docx; 3/16/18 Research in Context Evidence before this study Sodium glucose co-transporter 2 (SGLT2) inhibitors such as canagliflozin reduce
[Show full text]
Diabetes Drug Has Kidney-Protective Effects in Patients with Advanced Kidney Disease
ASN Contacts: Christine Feheley (202) 640-4638 | [email protected] Tracy Hampton [email protected] DIABETES DRUG HAS KIDNEY-PROTECTIVE EFFECTS IN PATIENTS WITH ADVANCED KIDNEY DISEASE Patients receive similar benefits from canagliflozin as those with earlier stages of kidney disease. Highlights • The diabetes drug canagliflozin slowed kidney function decline in patients with diabetes and advanced chronic kidney disease. • The drug also reduced the risk of developing kidney failure and cardiovascular problems in these patients. Washington, DC (November 19, 2020) — A recent analysis indicates that a drug shown previously to slow kidney disease progression is effective even in patients with advanced disease. The results appear in an upcoming issue of CJASN. The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial demonstrated that canagliflozin, a diabetes medication within a class called sodium glucose co-transporter 2 (SGLT2) inhibitors, reduced the risk of kidney failure and cardiovascular events in adults with type 2 diabetes and chronic kidney disease (CKD). Little is known about the use of SGLT2 inhibitors in patients with advanced CKD, however. To investigate, George Bakris, MD (University of Chicago Medicine) and his colleagues conducted a post hoc analysis of CREDENCE data pertaining to the 174 patients who had advanced CKD, or an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m2 at the start of the trial. The researchers found that canagliflozin slowed CKD progression compared with placebo, with a 66% difference (average eGFR declines of –1.30 vs. –3.83 mL/min/1.73 m2 per year). Also, canagliflozin’s effects on kidney, cardiovascular, and mortality outcomes were consistent with those seen for individuals with less advanced CKD.
[Show full text]
The TESTING Randomized Clinical Trial
Research JAMA | Original Investigation Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy The TESTING Randomized Clinical Trial Jicheng Lv, MD; Hong Zhang, PhD; Muh Geot Wong, PhD; Meg J. Jardine, PhD; Michelle Hladunewich, MD; Vivek Jha, MD; Helen Monaghan, PhD; Minghui Zhao, MD; Sean Barbour, MD; Heather Reich, MD; Daniel Cattran, MD; Richard Glassock, MD; Adeera Levin, FRCPC; David Wheeler, FRCP; Mark Woodward, PhD; Laurent Billot, MSc; Tak Mao Chan, MD; Zhi-Hong Liu, MD; David W. Johnson, MD; Alan Cass, FRACP; John Feehally, MD; Jürgen Floege, MD; Giuseppe Remuzzi, MD; Yangfeng Wu, MD; Rajiv Agarwal, MD; Hai-Yan Wang, MD; Vlado Perkovic, PhD; for the TESTING Study Group Editorial page 429 IMPORTANCE Guidelines recommend corticosteroids in patients with IgA nephropathy and Supplemental content persistent proteinuria, but the effects remain uncertain. CME Quiz at jamanetwork.com/learning OBJECTIVE To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression. DESIGN, SETTING, AND PARTICIPANTS The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1.73 m2 after at least 3 months of blood pressure control with renin-angiotensin system blockade] and to provide follow-up until 335 primary outcomes occurred. INTERVENTIONS Patients were randomized 1:1 to oral methylprednisolone (0.6-0.8 mg/kg/d; maximum, 48 mg/d) (n = 136) or matching placebo (n = 126) for 2 months, with subsequent weaning over 4 to 6 months.
[Show full text]