Amerithrax Investigative Summary
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Developing Drugs for Prophylaxis of Inhalational Anthrax Guidance for Industry
Anthrax: Developing Drugs for Prophylaxis of Inhalational Anthrax Guidance for Industry U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) May 2018 Clinical/Antimicrobial Anthrax: Developing Drugs for Prophylaxis of Inhalational Anthrax Guidance for Industry Additional copies are available from: Office of Communications, Division of Drug Information Center for Drug Evaluation and Research Food and Drug Administration 10001 New Hampshire Ave., Hillandale Bldg., 4th Floor Silver Spring, MD 20993-0002 Phone: 855-543-3784 or 301-796-3400; Fax: 301-431-6353; Email: [email protected] https://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) May 2018 Clinical/Antimicrobial TABLE OF CONTENTS I. INTRODUCTION............................................................................................................. 1 II. BACKGROUND ............................................................................................................... 2 A. Historical Background................................................................................................................... 2 B. Indication for Prophylaxis of Inhalational Anthrax ................................................................... 2 III. DEVELOPMENT PROGRAM ....................................................................................... 3 A. General -
Amerithrax Investigative Summary
The United States Department of Justice AMERITHRAX INVESTIGATIVE SUMMARY Released Pursuant to the Freedom of Information Act Friday, February 19, 2010 TABLE OF CONTENTS I. THE ANTHRAX LETTER ATTACKS . .1 II. EXECUTIVE SUMMARY . 4 A. Overview of the Amerithrax Investigation . .4 B. The Elimination of Dr. Steven J. Hatfill as a Suspect . .6 C. Summary of the Investigation of Dr. Bruce E. Ivins . 6 D. Summary of Evidence from the Investigation Implicating Dr. Ivins . .8 III. THE AMERITHRAX INVESTIGATION . 11 A. Introduction . .11 B. The Investigation Prior to the Scientific Conclusions in 2007 . 12 1. Early investigation of the letters and envelopes . .12 2. Preliminary scientific testing of the Bacillus anthracis spore powder . .13 3. Early scientific findings and conclusions . .14 4. Continuing investigative efforts . 16 5. Assessing individual suspects . .17 6. Dr. Steven J. Hatfill . .19 7. Simultaneous investigative initiatives . .21 C. The Genetic Analysis . .23 IV. THE EVIDENCE AGAINST DR. BRUCE E. IVINS . 25 A. Introduction . .25 B. Background of Dr. Ivins . .25 C. Opportunity, Access and Ability . 26 1. The creation of RMR-1029 – Dr. Ivins’s flask . .26 2. RMR-1029 is the source of the murder weapon . 28 3. Dr. Ivins’s suspicious lab hours just before each mailing . .29 4. Others with access to RMR-1029 have been ruled out . .33 5. Dr. Ivins’s considerable skill and familiarity with the necessary equipment . 36 D. Motive . .38 1. Dr. Ivins’s life’s work appeared destined for failure, absent an unexpected event . .39 2. Dr. Ivins was being subjected to increasing public criticism for his work . -
Molecular Subtyping of Bacillus Anthracis and the 2001 Bioterrorism-Associated Anthrax Outbreak, United States Alex R
BIOTERRORISM-RELATED ANTHRAX Molecular Subtyping of Bacillus anthracis and the 2001 Bioterrorism-Associated Anthrax Outbreak, United States Alex R. Hoffmaster,* Collette C. Fitzgerald,* Efrain Ribot,* Leonard W. Mayer,* and Tanja Popovic* Molecular subtyping of Bacillus anthracis played an important role in differentiating and identifying strains during the 2001 bioterrorism-associated outbreak. Because B. anthracis has a low level of genetic variabil- ity, only a few subtyping methods, with varying reliability, exist. We initially used multiple-locus variable- number tandem repeat analysis (MLVA) to subtype 135 B. anthracis isolates associated with the outbreak. All isolates were determined to be of genotype 62, the same as the Ames strain used in laboratories. We sequenced the protective antigen gene (pagA) from 42 representative outbreak isolates and determined they all had a pagA sequence indistinguishable from the Ames strain (PA genotype I). MLVA and pagA sequencing were also used on DNA from clinical specimens, making subtyping B. anthracis possible with- out an isolate. Use of high-resolution molecular subtyping determined that all outbreak isolates were indis- tinguishable by the methods used and probably originated from a single source. In addition, subtyping rapidly identified laboratory contaminants and nonoutbreak–related isolates. he recent bioterrorism-associated anthrax outbreak dem- subtype 26 diverse B. anthracis isolates into six PA genotypes T onstrated the need for rapid molecular subtyping of Bacil- (8). Although sequencing of pagA results in limited numbers lus anthracis isolates. Numerous methods, including multiple- of subtypes, it does have the added benefit of determining if locus enzyme electrophoresis (MEE) and multiple-locus the pagA gene has been altered or engineered. -
Newsletter 3-1-2016
The Newsletter of the American Pilots’ Association March 1, 2016 Page 1 (NAVTECH) will meet on Wednesday afternoon. In addition to discussing the latest issues in electronic navigation practice and equipment, plans are under way to have NAVTECH members hear from various While many pilots government officials with responsibilities for naviga- around the country are tion programs. dealing with the chills The Suppliers’ Exhibition, an excellent oppor- of winter, a warm is- tunity to meet with maritime and pilotage related land breeze is on the vendors to discuss their products, will be held on way. Plans are well Wednesday and Thursday. underway for the 2016 As always, several social events will be held Biennial Convention, which is being held from Octo- during the week, including a Welcome Reception on ber 24-28 at the beautiful Fairmont Kea Lani Hotel Monday, a traditional luau on Wednesday, and a and Resort in Maui. The Convention is an un- closing Gala on Friday. matched opportunity for the Nation’s pilots to gather, To make attendance arrangements, go to share ideas and strengthen the pilotage system in the www.americanpilots.org and click “2016 APA U.S. This year’s Convention is hosted by the nine Convention.” There, pilots and other attendees can pilot associations in the Pacific Coast States: Alaska book flights, make hotel reservations, and register Marine Pilots, Columbia River Pilots, Columbia Riv- for the Convention. Pilots can also view the Exhibi- er Bar Pilots, Coos Bay Pilots, Hawaii Pilots, Puget tor Directory by clicking on “Exhibitor Registration” Sound Pilots, San Francisco Bar Pilots, Southeast and dragging the mouse over the booth diagrams. -
UNITED STATES DISTRICT COURT for the DISTRICT of COLUMBIA FILED OCT 3 1 2007 in the Matter of the Search of NANCY MAYER WHITTINGTON CLERK U.S
AO106 (Rev.5/85) Affidavit for Search Warrant UNITED STATES DISTRICT COURT FOR THE DISTRICT OF COLUMBIA FILED OCT 3 1 2007 In the Matter of the Search of NANCY MAYER WHITTINGTON CLERK U.S. DISTRICT COURT Residence at APPLICATION AND AFFIDAVIT Frederick, Maryland, FOR SEARCH WARRANT owned by Bruce Edwards Ivins, DOB SSN CASE NUMBER: 07-524-M-01 I Thomas F. Dellafera being duly sworn depose and say: I am a(n) Postal Inspector with the U.S. Postal Inspection Service and have reason to believe (Official Title) that • on the person of or [ ] on the property or premises known as (name, description, and or location) Single Family Residence at Frederick, Maryland, and large white shed on rear of property owned by Bruce Edwards Ivins, DOB SSN in the District of Maryland, there is now concealed a certain person or property, namely trace quantities of Bacillus anthracis or simulants thereof, hairs, textile fibers, lab equipment or materials used in preparation of select agents, papers, tape, pens, notes, books, manuals, receipts, financial records of any type, correspondence, address books, maps, handwriting samples, photocopy samples, photographs, computer files, cellular phones, phone bills, electronic pager devices, other digital devices, or other documentary evidence. which is (state one or more bases for search and seizure set forth under Rule 41(b) of the Federal Rules of Criminal Procedure) evidence relevant to the commission of an act of terrorism, to include the use of a weapon of mass destruction (anthrax) and the murder and attempt to murder officers and employees of the United States in violation of Title 18 United States Code, Section(s) 2332a and 1114 , The facts to support a finding of Probable Cause are as fellows: SEE ATTACHED AFFIDAVIT HEREIN INCORPORATED BY REFERENCE AS IF FULLY RESTATED HEREIN Continued on the attached sheet and made a part hereof. -
Funk Is Its Own Reward": an Analysis of Selected Lyrics In
ABSTRACT AFRICAN-AMERICAN STUDIES LACY, TRAVIS K. B.A. CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS, 2000 "FUNK IS ITS OWN REWARD": AN ANALYSIS OF SELECTED LYRICS IN POPULAR FUNK MUSIC OF THE 1970s Advisor: Professor Daniel 0. Black Thesis dated July 2008 This research examined popular funk music as the social and political voice of African Americans during the era of the seventies. The objective of this research was to reveal the messages found in the lyrics as they commented on the climate of the times for African Americans of that era. A content analysis method was used to study the lyrics of popular funk music. This method allowed the researcher to scrutinize the lyrics in the context of their creation. When theories on the black vernacular and its historical roles found in African-American literature and music respectively were used in tandem with content analysis, it brought to light the voice of popular funk music of the seventies. This research will be useful in terms of using popular funk music as a tool to research the history of African Americans from the seventies to the present. The research herein concludes that popular funk music lyrics espoused the sentiments of the African-American community as it utilized a culturally familiar vernacular and prose to express the evolving sociopolitical themes amid the changing conditions of the seventies era. "FUNK IS ITS OWN REWARD": AN ANALYSIS OF SELECTED LYRICS IN POPULAR FUNK MUSIC OF THE 1970s A THESIS SUBMITTED TO THE FACULTY OF CLARK ATLANTA UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THEDEGREEOFMASTEROFARTS BY TRAVIS K. -
Bioterrorism & Biodefense
Hugh-Jones et al. J Bioterr Biodef 2011, S3 Bioterrorism & Biodefense http://dx.doi.org/10.4172/2157-2526.S3-001 Review Article Open Access The 2001 Attack Anthrax: Key Observations Martin E Hugh-Jones1*, Barbara Hatch Rosenberg2 and Stuart Jacobsen3 1Professor Emeritus, Louisiana State University; Anthrax Moderator, ProMED-mail, USA 2Sloan-Kettering Institute for Cancer Research and State Univ. of NY-Purchase (retired); Scientists Working Group on CBW, Center for Arms Control and Non-Proliferation, USA 3Technical Consultant Silicon Materials, Dallas, TX,USA Abstract Unresolved scientificquestions, remaining ten years after the anthrax attacks, three years after the FBI accused a dead man of perpetrating the 2001 anthrax attacks singlehandedly, and more than a year since they closed the case without further investigation, indictment or trial, are perpetuating serious concerns that the FBI may have accused the wrong person of carrying out the anthrax attacks. The FBI has not produced concrete evidence on key questions: • Where and how were the anthrax spores in the attack letters prepared? There is no material evidence of where the attack anthrax was made, and no direct evidence that any specific individual made the anthrax, or mailed it. On the basis of a number` of assumptions, the FBI has not scrutinized the most likely laboratories. • How and why did the spore powders acquire the high levels of silicon and tin found in them? The FBI has repeatedly insisted that the powders in the letters contained no additives, but they also claim that they have not been able to reproduce the high silicon content in the powders, and there has been little public mention of the extraordinary presence of tin. -
Twixt Ocean and Pines : the Seaside Resort at Virginia Beach, 1880-1930 Jonathan Mark Souther
University of Richmond UR Scholarship Repository Master's Theses Student Research 5-1996 Twixt ocean and pines : the seaside resort at Virginia Beach, 1880-1930 Jonathan Mark Souther Follow this and additional works at: http://scholarship.richmond.edu/masters-theses Part of the History Commons Recommended Citation Souther, Jonathan Mark, "Twixt ocean and pines : the seaside resort at Virginia Beach, 1880-1930" (1996). Master's Theses. Paper 1037. This Thesis is brought to you for free and open access by the Student Research at UR Scholarship Repository. It has been accepted for inclusion in Master's Theses by an authorized administrator of UR Scholarship Repository. For more information, please contact [email protected]. TWIXT OCEAN AND PINES: THE SEASIDE RESORT AT VIRGINIA BEACH, 1880-1930 Jonathan Mark Souther Master of Arts University of Richmond, 1996 Robert C. Kenzer, Thesis Director This thesis descnbes the first fifty years of the creation of Virginia Beach as a seaside resort. It demonstrates the importance of railroads in promoting the resort and suggests that Virginia Beach followed a similar developmental pattern to that of other ocean resorts, particularly those ofthe famous New Jersey shore. Virginia Beach, plagued by infrastructure deficiencies and overshadowed by nearby Ocean View, did not stabilize until its promoters shifted their attention from wealthy northerners to Tidewater area residents. After experiencing difficulties exacerbated by the Panic of 1893, the burning of its premier hotel in 1907, and the hesitation bred by the Spanish American War and World War I, Virginia Beach enjoyed robust growth during the 1920s. While Virginia Beach is often perceived as a post- World War II community, this thesis argues that its prewar foundation was critical to its subsequent rise to become the largest city in Virginia. -
AFFIDAVIT in SUPPORT of SEARCH WARRANT I, Charles B. Wickersham, Being Duly Sworn, Depose and Say: I Have Been a Postal Inspecto
AFFIDAVIT IN SUPPORT OF SEARCH WARRANT I, Charles B. Wickersham, being duly sworn, depose and say: I have been a Postal Inspector of the United States Postal Inspection Service (USPIS) for approximately twenty months. I am authorized to investigate crimes involving violations of Title 18 U.S.C. Sections 2332(a), 1 1 14, and 15 12(a)(2). This affidavit is respectfilly submitted in support of an application for warrants to search the following premises and vehicles, pursuant to the domestic terrorism search warrant provision found at Rule 41 (b)(3) of the Federal Rules of Criminal Procedure, in that it involves threats to witnesses in, and obstruction of, a domestic terrorism investigation, pending in the District of Columbia. (1) Frederick, Maryland, a single family residence: The residence has white painted wood siding, with a white front door that is located bn the right side of th; front of the home.- he front door has an exterior storm door. Left of the -front door are two windows cased with re A black railing leads up several stairs to the front door where the numbers re indicated in black above the door. The search will include a large white shed with peeling paint, that is located on the backyard. Bruce Edwards Ivins purchased the house has disclosed the property has been his principle #I: a vehicle with Maryland and Vehicle Identification Number The vehicle , Frederick, MD. Bruce Edwards Ivins purchased the vehicle owner, and is the primary user. mobile #2: search a vehicle with Marylan (3) b and Vehicle Identification Number is described as ,' blue, 4 door sedan, and is registered to Bruce Edwards Ivins, Frederick, MD. -
Behind the Deadly Secrets at Fort Detrick
CHINA DAILY | HONG KONG EDITION Monday, July 12, 2021 | 11 WORLD Behind the deadly secrets at Fort Detrick One of the US’ biological laboratories raises serious questions about safety By ZHAO RUINAN seasons, starting from October 2019 [email protected] to March 2020, which the CDC said had led to 39 million illnesses and Despite numerous accidents more than 24,000 deaths. relating to viruses in biological Speculation about the laboratory research laboratories in the Unit- being the origin of the COVID-19 ed States over the years, most seem pandemic have also emerged to gain scant media or public online. attention. Robert Redfield, then director of More than 1,100 laboratory inci- the CDC, admitted in March last dents involving bacteria, viruses year that some COVID-19 deaths in and toxins that pose significant or the US had been diagnosed as flu-re- bioterrorism risks to people and lated. Redfield served as the director agriculture were reported to US fed- of the CDC from March 2018 to Jan- eral regulators between 2008 and uary this year. 2012, USA Today reported, citing US In March last year a petition in government reports it said it had which the signatories sought more obtained. information on Fort Detrick was An article last August by ProPub- posted on the White House website. lica, an independent newsroom that US politicians have dismissed the does investigative journalism, said concerns about the center as disin- that between January 2015 and June formation and conspiracy theories, 2020 the University of North Caroli- and at the same time pushed their na at Chapel Hill reported to safety own claims about the supposed ori- officials at the National Institutes of gins of COVID-19. -
Vaccination of Rhesus Macaques with the Anthrax Vaccine Adsorbed
CLINICAL AND VACCINE IMMUNOLOGY, Nov. 2010, p. 1753–1762 Vol. 17, No. 11 1556-6811/10/$12.00 doi:10.1128/CVI.00174-10 Copyright © 2010, American Society for Microbiology. All Rights Reserved. Vaccination of Rhesus Macaques with the Anthrax Vaccine Adsorbed Vaccine Produces a Serum Antibody Response That Effectively Neutralizes Receptor-Bound Protective Antigen In Vitroᰔ Kristin H. Clement,1* Thomas L. Rudge, Jr.,1 Heather J. Mayfield,1 Lena A. Carlton,1 Arelis Hester,1 Nancy A. Niemuth,1 Carol L. Sabourin,1 April M. Brys,1 and Conrad P. Quinn2 Battelle Memorial Institute, 505 King Avenue, Columbus, Ohio 43201,1 and Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303332 Received 29 April 2010/Returned for modification 17 June 2010/Accepted 19 August 2010 Anthrax toxin (ATx) is composed of the binary exotoxins lethal toxin (LTx) and edema toxin (ETx). They have separate effector proteins (edema factor and lethal factor) but have the same binding protein, protective antigen (PA). PA is the primary immunogen in the current licensed vaccine anthrax vaccine adsorbed (AVA [BioThrax]). AVA confers protective immunity by stimulating production of ATx-neutralizing antibodies, which could block the intoxication process at several steps (binding of PA to the target cell surface, furin cleavage, toxin complex formation, and binding/translocation of ATx into the cell). To evaluate ATx neutral- ization by anti-AVA antibodies, we developed two low-temperature LTx neutralization activity (TNA) assays that distinguish antibody blocking before and after binding of PA to target cells (noncomplexed [NC] and receptor-bound [RB] TNA assays). -
44 Records of the Index of American Design
Finding Aid for the Records of the Index of American Design, 1929-2018 (bulk 1936-1942) Summary Information Repository National Gallery of Art, Gallery Archives Sixth Street and Constitution Avenue, NW Washington, DC 20565 [email protected] Title Records of the Index of American Design Identifier 44 Creator United States. Works Progress Administration. Index of American Design. Date 1929-2018 (bulk 1936-1942) Extent 290 cubic feet (734 boxes); approximately 29,000 digital files Abstract This collection documents the activities of the Index of American Design, a Federal Art Project to preserve and document the development of American folk and decorative arts from the colonial period through 1900 while providing relief work to unemployed artists, researchers, and photographers during the Great Depression. Materials consist of correspondence, memoranda, reports, lists, data sheets, publications, photograph prints and negatives, color notes. Historical Note Created in 1935, the Index of American Design (Index) was a program in the Fine Arts Divisions of the Federal Art Project (FAP) under the Works Progress Administration (WPA). The Index project had three objectives: to employ and maintain the skills of artists who found themselves unemployed during the depression years; to preserve America’s artistic and cultural heritage by documenting the development of arts and crafts in different parts of the country; and to create a series of portfolios from the Index watercolor renderings that would serve as a permanent guide for artists, scholars, and the public. The initial idea for the Index project began with discussions between Romana Javitz, head of the New York Public Library’s Picture Collection, and artists who were conducting research in the collection for WPA projects.