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WHO Guidelines for the Treatment of Neisseria Gonorrhoeae* Web Annex E Systematic Reviews

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WHO Guidelines for the Treatment of Neisseria Gonorrhoeae* Web Annex E Systematic Reviews WHO guidelines for the treatment of Neisseria gonorrhoeae* Web annex E Systematic reviews WHO Library Cataloguing-in-Publication Data WHO guidelines for the treatment of Neisseria gonorrhoeae. Contents: Web annex D: Evidence profiles and evidence-to-decision framework -- Web annex E: Systematic reviews -- Web annex F: Summary of conflicts of interest 1.Neisseria gonorrhoeae - drug therapy. 2.Gonorrhea - drug therapy. 3.Drug Resistance, Microbial. 4.Guideline. I.World Health Organization. ISBN 978 92 4 154969 1 (NLM classification: WC 150) © World Health Organization 2016 All rights reserved. Publications of the World Health Organization are available on the WHO website (http://www.who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; email: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for non-commercial distribution– should be addressed to WHO Press through the WHO website (http://www.who.int/about/licensing/copyright_form/index.html). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. Printed by the WHO Document Production Services, Geneva, Switzerland *The full guidelines and annexes are available at: www.who.int/reproductivehealth/publications/rtis/gonorrhoea-treatment-guidelines/en/ For more information, please contact: Department of Reproductive Health and Research E-mail: [email protected] www.who.int/reproductivehealth 1 Contents Recommendation 1 ................................................................................................................................................... 1 1.1 In adults and adolescents, HIV-positive patients and men who have sex with men (MSM) with uncomplicated genital (cervix, urethra) and anorectal gonococcal infections, should other treatments or ceftriaxone be used to treat gonorrhoea (genital or cervix)? ............ 1 Criteria............................................................................................................................................................................... 1 Search ................................................................................................................................................................................ 1 For systematic reviews .................................................................................................................................................. 1 For randomized and non-randomized studies .............................................................................................................. 1 Screening of studies and data extraction ......................................................................................................................... 2 Methods of analysis .......................................................................................................................................................... 4 Results ............................................................................................................................................................................... 4 PRISMA .............................................................................................................................................................................. 5 Characteristics of included studies ................................................................................................................................... 6 Effects of interventions ................................................................................................................................................... 25 Risk of bias ...................................................................................................................................................................... 58 References ...................................................................................................................................................................... 73 1.2 In pregnant women with uncomplicated genital (cervix, urethra) and anorectal gonococcal infections, what are the effects of ceftriaxone compared to other treatments? ........ 78 Criteria............................................................................................................................................................................. 78 Search .............................................................................................................................................................................. 78 For systematic reviews ................................................................................................................................................ 78 For randomized and non-randomized studies ............................................................................................................ 78 Screening of studies and data extraction ....................................................................................................................... 79 Methods of analyses ....................................................................................................................................................... 79 Results ............................................................................................................................................................................. 80 PRISMA ............................................................................................................................................................................ 80 Characteristics of included studies ................................................................................................................................. 82 Effects of intervention .................................................................................................................................................... 82 Risk of bias ...................................................................................................................................................................... 88 References ...................................................................................................................................................................... 88 Patient values, preferences and acceptability ................................................................................................................ 89 Gonococcal infections ..................................................................................................................................................... 89 Search .............................................................................................................................................................................. 89 Result .............................................................................................................................................................................. 89 Characteristics of included studies ................................................................................................................................. 89 Findings: acceptability ..................................................................................................................................................... 89 Other conditions: syphilis ............................................................................................................................................... 90 Search .............................................................................................................................................................................. 90 Result .............................................................................................................................................................................. 90 Characteristics of included studies ................................................................................................................................. 90 Findings ........................................................................................................................................................................... 91 References .....................................................................................................................................................................
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