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The Use of Nitrous Oxide Gas for Lower Gastrointestinal Endoscopy Sophie Welchman, Sean Cochrane, Gary Minto, Stephen Lewis
Systematic review: The use of nitrous oxide gas for lower gastrointestinal endoscopy Sophie Welchman, Sean Cochrane, Gary Minto, Stephen Lewis To cite this version: Sophie Welchman, Sean Cochrane, Gary Minto, Stephen Lewis. Systematic review: The use of nitrous oxide gas for lower gastrointestinal endoscopy. Alimentary Pharmacology and Therapeutics, Wiley, 2010, 32 (3), pp.324. 10.1111/j.1365-2036.2010.04359.x. hal-00552574 HAL Id: hal-00552574 https://hal.archives-ouvertes.fr/hal-00552574 Submitted on 6 Jan 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Alimentary Pharmacology & Therapeutic Systematic review: The use of nitrous oxide gas for lower gastrointestinal endoscopy ForJournal: Alimentary Peer Pharmacology Review & Therapeutics Manuscript ID: APT-0287-2010.R1 Manuscript Type: Systematic Review Date Submitted by the 13-May-2010 Author: Complete List of Authors: Welchman, Sophie; Derriford Hospital, Surgery Cochrane, Sean; Derriford Hospital, Gastroenterology Minto, Gary; Derriford Hospital, Anaesthesia Lewis, stephen; Derriford Hospital, -
Alkaloid Diversification in the Genus Palicourea (Rubiaceae
Phytochem Rev https://doi.org/10.1007/s11101-021-09768-y (0123456789().,-volV)( 0123456789().,-volV) Alkaloid diversification in the genus Palicourea (Rubiaceae: Palicoureeae) viewed from a (retro-)biogenetic perspective Andreas Berger . Karin Valant-Vetschera . Johann Schinnerl . Lothar Brecker Received: 26 December 2020 / Accepted: 17 July 2021 Ó The Author(s) 2021 Abstract The species-rich genus Palicourea (Rubi- Keywords Palicoureeae Á Alkaloid classification Á aceae: Palicoureeae) is source of an intriguing diver- Biosynthesis Á Chemosystematics Á Chemodiversity sity of alkaloids derived from tryptamine and its precursor tryptophan. So far simple tryptamine ana- Abbreviations logues, polypyrroloindoline, b-carboline, and, most CrSTR Catharanthus roseus strictosidine synthase importantly, monoterpene-indole, i.e., tryptamine-iri- IA Indole alkaloid doid alkaloids of various structural types including INMT Indolethylamine N-methyltransferase javaniside, alstrostine and strictosidine derivatives MIA Monoterpene-indole alkaloid have been identified. Here the diverse alkaloids that OpSTR Ophiorrhiza pumila strictosidine synthase numerous studies have found in the genus are exam- PSR Pictet-Spengler reaction ined and organized according to their structures and RsSTR Rauvolfia serpentina strictosidine synthase biosynthetic groups. Using a parsimony-based SLS Secologanin synthase approach that follows the concept of retro-biogenesis SmGD Strychnos mellodora glucosidase usually applied in synthetic chemistry, possible STR Strictosidine synthase biosynthetic pathways are proposed and important T5H Tryptamine 5-hydroxylase steps and relationships between these alkaloids are TDC Tryptophan decarboxylase highlighted. Understanding alkaloid diversification is SGD Strictosidine ß-glucosidase of importance in studying the ecological significance and evolution of biosynthetic capabilities of the genus Palicourea, and should stimulate future investigations on the biochemical and genetic background. Introduction A. -
Ketamine for Chronic Non- Cancer Pain: a Review of Clinical Effectiveness, Cost- Effectiveness, And
CADTH RAPID RESPONSE REPORT: SUMMARY WITH CRITICAL APPRAISAL Ketamine for Chronic Non- Cancer Pain: A Review of Clinical Effectiveness, Cost- Effectiveness, and Guidelines Service Line: Rapid Response Service Version: 1.0 Publication Date: May 28, 2020 Report Length: 28 Pages Authors: Khai Tran, Suzanne McCormack Cite As: Ketamine for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines. Ottawa: CADTH; 2020 May. (CADTH rapid response report: summary with critical appraisal) ISSN: 1922-8147 (online) Disclaimer: The information in this document is intended to help Canadian health care decision-makers, health care professionals, health systems leaders, and policy-makers make well-informed decisions and thereby improve the quality of health care services. While patients and others may access this document, the document is made available for informational purposes only and no representations or warranties are made with respect to its fitness for any particular purpose. The information in this document should not be used as a substitute for professional medical advice or as a substitute for the application of clinical judgment in respect of the care of a particular patient or other professional judgment in any decision-making process. The Canadian Agency for Drugs and Technologies in Health (CADTH) does not endorse any information, drugs, therapies, treatments, products, processes, or services. While care has been taken to ensure that the information prepared by CADTH in this document is accurate, complete, and up-to-date as at the applicable date the material was first published by CADTH, CADTH does not make any guarantees to that effect. CADTH does not guarantee and is not responsible for the quality, currency, propriety, accuracy, or reasonableness of any statements, information, or conclusions contained in any third-party materials used in preparing this document. -
High Rates of Tramadol Use Among Treatment-Seeking Adolescents in Malmö, Sweden: a Study of Hair Analysis of Nonmedical Prescription Opioid Use
Hindawi Journal of Addiction Volume 2017, Article ID 6716929, 9 pages https://doi.org/10.1155/2017/6716929 Research Article High Rates of Tramadol Use among Treatment-Seeking Adolescents in Malmö, Sweden: A Study of Hair Analysis of Nonmedical Prescription Opioid Use Martin O. Olsson,1 Agneta Öjehagen,1 Louise Brådvik,1 Robert Kronstrand,2,3 and Anders Håkansson1 1 Psychiatry, Department of Clinical Sciences, Lund, Faculty of Medicine, Lund University, 221 00 Lund, Sweden 2Department of Forensic Genetics and Forensic Toxicology, Swedish National Board of Forensic Medicine, Linkoping,¨ Sweden 3Division of Drug Research, Linkoping¨ University, 581 85 Linkoping,¨ Sweden Correspondence should be addressed to Martin O. Olsson; martin [email protected] Received 21 September 2017; Accepted 6 December 2017; Published 24 December 2017 Academic Editor: Leandro F. Vendruscolo Copyright © 2017 Martin O. Olsson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Nonmedical prescription opioid use (NMPOU) is a growing problem and tramadol has been suggested as an emerging problem in young treatment-seeking individuals. The aim of the present study was to investigate, through hair analysis, NMPOU in this group and, specifically, tramadol use. Methods. In a study including 73 treatment-seeking adolescents and young adults at an outpatient facility for young substance users, hair specimens could be obtained from 59 subjects. Data were extracted on sociodemographic background variables and psychiatric diagnoses through MINI interviews. Results. In hair analysis, tramadol was by far the most prevalent opioid detected. -
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Maternal Use of Opioids During Pregnancy and Congenital Malformations: a Systematic Review
Maternal Use of Opioids During Jennifer N. Lind, PharmD, MPH, a, b Julia D. Interrante, MPH, a, c Elizabeth C. Ailes, PhD, MPH, a Suzanne M. Gilboa, PhD, a PregnancySara Khan, MSPH, a, d, e Meghan T. Frey, and MA, MPH, a CongenitalApril L. Dawson, MPH, a Margaret A. Honein, PhD, MPH, a a a, b f, g a Malformations:Nicole F. Dowling, PhD, Hilda Razzaghi, PhD, MSPH, A Andreea Systematic A. Creanga, MD, PhD, Cheryl Review S. Broussard, PhD CONTEXT: abstract Opioid use and abuse have increased dramatically in recent years, particularly OBJECTIVES: among women. We conducted a systematic review to evaluate the association between prenatal DATA SOURCES: opioid use and congenital malformations. We searched Medline and Embase for studies published from 1946 to 2016 and STUDY SELECTION: reviewed reference lists to identify additional relevant studies. We included studies that were full-text journal articles and reported the results of original epidemiologic research on prenatal opioid exposure and congenital malformations. We assessed study eligibility in multiple phases using a standardized, DATA EXTRACTION: duplicate review process. Data on study characteristics, opioid exposure, timing of exposure during pregnancy, congenital malformations (collectively or as individual subtypes), length of RESULTS: follow-up, and main findings were extracted from eligible studies. Of the 68 studies that met our inclusion criteria, 46 had an unexposed comparison group; of those, 30 performed statistical tests to measure associations between maternal opioid use during pregnancy and congenital malformations. Seventeen of these (10 of 12 case-control and 7 of 18 cohort studies) documented statistically significant positive associations. Among the case-control studies, associations with oral clefts and ventricular septal defects/atrial septal defects were the most frequently reported specific malformations. -
The Use of Central Nervous System Active Drugs During Pregnancy
Pharmaceuticals 2013, 6, 1221-1286; doi:10.3390/ph6101221 OPEN ACCESS pharmaceuticals ISSN 1424-8247 www.mdpi.com/journal/pharmaceuticals Review The Use of Central Nervous System Active Drugs During Pregnancy Bengt Källén 1,*, Natalia Borg 2 and Margareta Reis 3 1 Tornblad Institute, Lund University, Biskopsgatan 7, Lund SE-223 62, Sweden 2 Department of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Stockholm SE-106 30, Sweden; E-Mail: [email protected] 3 Department of Medical and Health Sciences, Clinical Pharmacology, Linköping University, Linköping SE-581 85, Sweden; E-Mail: [email protected] * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +46-46-222-7536, Fax: +46-46-222-4226. Received: 1 July 2013; in revised form: 10 September 2013 / Accepted: 25 September 2013 / Published: 10 October 2013 Abstract: CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson’s disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996–2011) are presented. The exposure data are either based on midwife interviews towards the end of the first trimester or on linkage with a prescribed drug register. -
WO 2017/066488 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2017/066488 A l 2 0 April 2017 (20.04.2017) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/485 (2006.01) A61P 25/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/5415 (2006.01) A61P 1/08 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 16/0569 10 HN, HR, HU, ID, IL, EST, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 13 October 2016 (13.10.201 6) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/240,965 13 October 2015 (13. 10.2015) US (84) Designated States (unless otherwise indicated, for every 62/300,014 25 February 2016 (25.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CHARLESTON LABORATORIES, INC. -
Anaesthetic Technique Does Not Influence Postoperative Bowel Function: a Comparison of Propofol, Nitrous Anders G
938 Anaesthetic technique does not influence postoperative bowel function: a comparison of propofol, nitrous Anders G. Jensen MO DEAA,* Sigga H. Kalman MD,* oxide and isoflurane Per-Olof Nystr6m MD PhD,i" Christina Eintrei MD Phl)* The aim of this study was to evaluate the influence of propofol, of enteral intake median day 5 (1-10), was found in all groups. nitrous oxide and isoflurane on recovery, postoperative bowel The incidence of complications and the length of postoperative function and postoperative complications after major gastro- hospital stay, median 11 (6--45) days, did not differ among the intestinal surgery. Sixty patients undergoing elective colonic groups. It is concluded that overall recovery, bowel function, operations were included in the study. They were randomly postoperative hospital stay, and complications were not in- allocated to anaesthesia with isoflurane-nitrous oxide, propofol- fluenced by the anaesthetic technique. air, or propofol-nitrous oxide, with fentanyl and vecuronium being used in all three groups. The same anaesthetic and L'objectif de cette ~tude est d'~valuer l'influence du propofol, surgical teams performed all the operations. The postoperative du protoxyde d'azote et de l'isoflurane sur la r6tablissement, course was judged once each day by the Acute Physiology Score l'activit# intestinale et les complications aprks une chirurgie (APS) based on the Apache H classification, passage of gas, gastro-intestinale majeure. L'~tude inclut soixante patients tolerance of enteral feeding, hospital stay and complications up subissant une intervention non urgente sur le colon, lls sont to 30 days after surgery. The demographic data, magnitude of distribu~s de fafon aldatoire en trois groupes : isoflurane- operation, duration of operation, intraoperative blood loss, and protoxyde, propofol-air, propofol-protoxyde. -
Narcotic Drugs Stupefiants Estupefacientes
E/INCB/1993/21Supp.6 INTERNATIONAL NARCOTICS CONTROL BOARD - VIENNA SUPPLEMENT No. 6 TO NARCOTIC DRUGS ESTIMATED WORLD REQUIREMENTS FOR 1994 STATISTICS FOR 1992 ESTIMATES UPDATED AS OF 30 JUNE 1994 ORGANE INTERNATIONAL DE CONTROLE DES STUPEFIANTS - VIENNE SUPPLEMENT N° 6 A r STUPEFIANTS EVALUATIONS DES BESOINS DU MONDE POUR 1994 STATISTIQUES POUR 1992 EVALUATIONS A JOUR AU 30 JUlN 1994 JUNTA INTERNACIONAL DE FISCALlZACION DE ESTUPEFACIENTES - VIENA SUPLEMENTO N.o 6 A ESTUPEFACIENTES PREVISIONES DE LAS NECESIDADES MUNDIALES PARA 1994 ESTADfsTICAS PARA 1992 PREVISIONES ACTUALlZADAS AL 30 DE JUNIO DE 1994 ~If..~~ ~ ~-tR UNITED NATIONS - NATIONS UNIES - NACIONES UNIDAS 1994 The updating of Table A is carried out by means of 12 monthly supplements. In order to facilitate the task of the exporting countries, the 12 supplements now report all the totals of the estimates and not only the amended data. In this way, each supplement cancels and replaces the published table in its entirety. In order to accelerate the transmission of the supplements to the competent national authorities, the 12 supplements will appear in English. Reading of these 12 supplements in French and Spanish may be facilitated by consulting the indexes of countries and territories and of narcotic drugs appearing in the annual publication. La mise El jour du tableau A s'effectue au moyen de douze supplements mensuels. Afin de faciliter la tache des pays exportateurs, les douze supplements contiennent tous les totaux des evaluations et non pas seulement les chiffres qui ont ete modifies. De celte maniere, chaque supplement annule et remplace entierement le tableau publie. -
(12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley Et Al
US 2014O144429A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley et al. (43) Pub. Date: May 29, 2014 (54) METHODS AND DEVICES FOR COMPOUND (60) Provisional application No. 61/887,045, filed on Oct. DELIVERY 4, 2013, provisional application No. 61/831,992, filed on Jun. 6, 2013, provisional application No. 61/794, (71) Applicant: E-NICOTINE TECHNOLOGY, INC., 601, filed on Mar. 15, 2013, provisional application Draper, UT (US) No. 61/730,738, filed on Nov. 28, 2012. (72) Inventors: Martin Wensley, Los Gatos, CA (US); Publication Classification Michael Hufford, Chapel Hill, NC (US); Jeffrey Williams, Draper, UT (51) Int. Cl. (US); Peter Lloyd, Walnut Creek, CA A6M II/04 (2006.01) (US) (52) U.S. Cl. CPC ................................... A6M II/04 (2013.O1 (73) Assignee: E-NICOTINE TECHNOLOGY, INC., ( ) Draper, UT (US) USPC ..................................................... 128/200.14 (21) Appl. No.: 14/168,338 (57) ABSTRACT 1-1. Provided herein are methods, devices, systems, and computer (22) Filed: Jan. 30, 2014 readable medium for delivering one or more compounds to a O O Subject. Also described herein are methods, devices, systems, Related U.S. Application Data and computer readable medium for transitioning a Smoker to (63) Continuation of application No. PCT/US 13/72426, an electronic nicotine delivery device and for Smoking or filed on Nov. 27, 2013. nicotine cessation. Patent Application Publication May 29, 2014 Sheet 1 of 26 US 2014/O144429 A1 FIG. 2A 204 -1 2O6 Patent Application Publication May 29, 2014 Sheet 2 of 26 US 2014/O144429 A1 Area liquid is vaporized Electrical Connection Agent O s 2. -
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