Role of Acid Sphingomyelinase and IL-6 As Mediators Of
Thorax Online First, published on July 27, 2016 as 10.1136/thoraxjnl-2015-208067 Respiratory research ORIGINAL ARTICLE Thorax: first published as 10.1136/thoraxjnl-2015-208067 on 27 July 2016. Downloaded from Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction Rachele Pandolfi,1,2,3 Bianca Barreira,1,2,3 Enrique Moreno,1,2,3 Victor Lara-Acedo,2 Daniel Morales-Cano,1,2,3 Andrea Martínez-Ramas,1,2,3 Beatriz de Olaiz Navarro,4 Raquel Herrero,1,5 José Ángel Lorente,1,5,6 Ángel Cogolludo,1,2,3 Francisco Pérez-Vizcaíno,1,2,3 Laura Moreno1,2,3 ▸ Additional material is ABSTRACT published online only. To view Background Pulmonary hypertension (PH) is frequently Key messages please visit the journal online (http://dx.doi.org/10.1136/ observed in patients with acute respiratory distress thoraxjnl-2015-208067). syndrome (ARDS) and it is associated with an increased risk of mortality. Both acid sphingomyelinase (aSMase) 1Ciber Enfermedades What is the key question? Respiratorias (CIBERES), activity and interleukin 6 (IL-6) levels are increased in ▸ Pulmonary hypertension and right ventricular Madrid, Spain patients with sepsis and correlate with worst outcomes, dysfunction are prominent prognostic features 2 Department of Pharmacology, but their role in pulmonary vascular dysfunction of acute respiratory distress syndrome (ARDS) School of Medicine, pathogenesis has not yet been elucidated. Therefore, the which, given the unclear pathophysiology and Universidad Complutense de Madrid, Madrid, Spain aim of this study was to determine the potential the lack of approved pharmacological therapies, 3Gregorio Marañón Biomedical contribution of aSMase and IL-6 in the pulmonary demand the identification of new therapeutic Research Institution (IiSGM), vascular dysfunction induced by lipopolysaccharide (LPS).
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