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Supplementary Information

Effects of - System Inhibitors on Mortality and Cardiovascular Outcomes in

Peritoneal Dialysis Patients: A Systematic Review and Meta-Analysis

Authors: Surapon Nochaiwong*, Chidchanok Ruengorn, Pajaree Mongkhon, Kednapa Thavorn,

Ratanaporn Awiphan, Kajohnsak Noppakun, Surachet Vongsanim, Wilaiwan Chongruksut, Brian

Hutton, Manish M. Sood, Greg A. Knoll; for the Thai Renal Outcomes Research (THOR)

Investigators

*Correspondence and requests for materials:

Surapon Nochaiwong, PharmD, Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang

Mai University, Chiang Mai 50200, Thailand, Phone: 66899973365, Fax: 6653222741, Email: [email protected]

Supplementary Online Content

Appendix 1 Systematic review search strategy S3

Appendix 2 Grey literature from ongoing clinical trial register S14

S2 Appendix 1. Systematic review search strategy: Ovid MEDLINE(R) and Epub Ahead of Print, In- Process & Other Non-Indexed Citations, Daily and Versions(R) 1946 to May 31, 2019 Search Query Items Found #1 exp Peritoneal Dialysis/ 25536 #2 *dialysis, peritoneal/ 13095 #3 exp Continuous Ambulatory Peritoneal Dialysis/ 9861 #4 (Peritoneal Dialysis or Continuous Ambulatory Peritoneal Dialysis).tw,kw,rn. 24380 #5 (PD or CAPD or CCPD or APD or IPD or NIPD or TPD).tw,kw,rn. 139515 #6 or/1-5 158122 #7 exp Renin-Angiotensin System/ 16650 #8 ((Renin-Angiotensin System or RAS) adj (inhibitor* or blockade* or antagonist*)).tw. 2108 #9 Angiotensi*.tw. 103240 #10 or/7-9 107070 #11 6 and 10 1327 #12 exp Angiotensin-converting enzyme inhibitors/ 42532 #13 ((Angiotensin-Converting Enzyme or Angiotensin I-Converting Enzyme or ACE or 32966 Kininase II) adj (inhibitor* or antagonist*)).tw. #14 (ACEI or ACEIs).tw,kw,rn 4064 #15 ( or Benezepril hydrochloride or Benazepril HCl, or Briem or Cibace or Cibacen 795 or Cibacen CHF or Cibacene or Labopol or Lotensin or Lotrel or Tensanil or Zinadril or 86541-75-5).tw,kw,rn #16 exp / 9934 #17 (Captopril or Acediur or Aceplus or Acepress or Acepril or Alopresin or Asisten or 13171 Captoten or Captolane or Captoprilum or Captopryl or Captoril or Cesplon or Dilabar or Farcopril or Garranil or Hypertil or Hypopress or Isopresol or L-Captopril or Lopirin or Lopril or Novocaptopril or Tenosbon or Tensoprel or Zapto or 62571-86-2).tw,kw,rn #18 exp / 535 #19 (Cilazapril or Dynorm or Inhibace or Vascace or 88768-40-5).tw,kw,rn 637 #20 ( or alindapril or Delaket or Adecut or Beniod or 83435-66-9).tw,kw,rn 155 #21 exp / 6612 #22 (Enalapril or Bonuten or Enalaprila or Enalaprilum or Gadopril or Kinfil or 75847-73- 8456 3).tw,kw,rn #23 exp / 418 #24 (Fosinopril or Dynacil or Fosenopril or Fosinil or Fosinorm or Fositens or Fozitec or 590 Hiperlex or Monopril or Newace or Staril or Tenso Stop or Tensocardil or 98048-97- 6).tw,kw,rn #25 ( or Tanatril or 89371-37-9).tw,kw,rn 287 #26 exp / 2014 #27 (Lisinopril or Lisinopril dehydrate or Prinivil or Renacor or Zestril or 83915-83-7).tw,kw,rn 2883 #28 ( or Univasc or 103775-10-6).tw,kw,rn 109 #29 exp / 1675 #30 (Perindopril or Aceon or Covapril or Coversyl or Pirindopril or Prestarium or 82834-16- 2164 0).tw,kw,rn #31 exp / 631 #32 (Quinapril or Quinapril hydrochloride or Quinapril HCl or Accupril or Accuprin or 974 Accupron or Acequin or Acuitel or Acuprel or Asig or Conan or Continucor or Ectren or Hemokvin or Korec or Koretic or Lidaltrin or Quinazil or 85441-61-8).tw,kw,rn #33 exp / 1998

S3 #34 (Ramipril or Acovil or Altace or Carasel or Cardace or Delix or Hytren or Lostapres or 5346 Naprix or Pramace or Quark or Ramace or Ramiprilum or Ramipro or Triatec or Tritace or Vesdil or Zabien or 87333-19-5).tw,kw,rn #35 ( or Renormax or 83647-97-6).tw,kw,rn 144 #36 ( or Temocaprilum or Acecol or 111902-57-9).tw,kw,rn 184 #37 ( or Gopten or Mavik or Odrik or Udrik or 87679-37-6).tw,kw,rn 704 #38 ( or Zocardis or 81872-10-8).tw,kw,rn 187 #39 or/12-38 62507 #40 6 and 39 423 #41 exp Angiotensin Receptor Antagonists/ 22632 #42 exp Angiotensin II Type 1 Receptor Blockers/ 17269 #43 ((angiotensin or AT 2 receptor) adj3 (antagonist* or block*)).tw 19190 #44 (Sartan or Sartans).tw,kw,rn. 292 #45 (ARB or ARBs).tw,kw,rn. 6277 #46 ( or Azilsartan medoxomil or Edarbi or 147403-03-0).tw,kw,rn. 192 #47 ( or Candesartan cilexetil or Amias or Atacand or Blopress or Ratacand or 3172 139481-59-7).tw,kw,rn. #48 ( or Teveten or 133040-01-4).tw,kw,rn. 390 #49 ( or Fimanta or Fimagen or Kanarb or 247257-48-3).tw,kw,rn. 83 #50 exp / 1198 #51 (Irbesartan or Aprovel or Avapro or Karvea or 138402-11-6).tw,kw,rn. 1785 #52 exp / 6548 #53 (Losartan or Cozaar or Losartan Monopotassium Salt or Lorsartan Potassium or 114798-26- 9501 4).tw,kw,rn. #54 ( or Olmesartan medoxomil or Benicar or Omesartan or Olmetec or Votum or 1555 144689-63-4).tw,kw,rn. #55 ( or 145733-36-4).tw,kw,rn. 16 #56 exp / 1598 #57 (Telmisartan or Kinzalmono or Micardis or Pritor or 144701-48-4).tw,kw,rn. 2282 #58 exp / 2185 #59 (Valsaetan or Diovan or Kalpress or Miten or Nisis or Provas or Tareg or Vals or Valtan or 2171 Valzaar or 137862-53-4).tw,kw,rn. #60 or/41-59 37772 #61 6 and 60 936 #62 11 or 40 or 61 1488 #63 exp Adolescent/ not (exp Adult/ and Adolescent/) 578726 #64 exp Child/ not (exp Adult/ and exp Child/) 1160496 #65 exp Infant/ not (exp Adult/ and exp Infant/) 805603 #66 or/63-65 1804229 #67 62 not 66 1461 #68 exp Animals/ not (Humans/ and exp Animals/) 4585086 #69 67 not 68 589 #70 (comment or editorial or interview or letter or news or newspaper article).pt. 1955104 #71 69 not 70 571 #72 randomized controlled trial/ or controlled clinical trial/ 571256 #73 (randomi#ed or randomly or RCT$1 or placebo*).tw,kw. 905371 #74 ((singl* or doubl* or trebl* or tripl*) adj (mask* or blind* or dumm*)).tw,kw. 164134 #75 trial.ti. 199418 #76 controlled clinical trial/ 93091

S4 #77 (control* adj2 trial*).tw,kw. 244591 #78 or/72-77 1164272 #79 71 and 78 61 #80 (nRCT or nRCTs or non-RCT?).tw,kw. 763 #81 (control* adj3 ("before and after" or "before after")).tw,kw. 4009 #82 (time series adj3 interrupt*).tw,kw. 2527 #83 (pre- adj3 post-).tw,kw. 73888 #84 (pretest adj3 posttest).tw,kw. 4986 #85 (control* adj2 stud$3).tw,kw. 216965 #86 control group/ 1620 #87 (control* adj2 group$1).tw,kw. 465988 #88 or/80-87 725660 #89 71 and 88 34 #90 exp comparative study/ 1831067 #91 ((comparative or comparison) adj (study or studies)).tw,kw. 103950 #92 exp cohort study/ 1862035 #93 (cohort* adj2 stud$3).tw,kw. 197141 #94 exp case control study/ 995765 #95 ((case-control* or case-based or case-comparison) adj (study or studies)).tw,kw. 98609 #96 or/90-95 3693772 #97 71 and 96 120 #98 79 or 89 or 97 173

S5 Appendix 1. Systematic review search strategy: OVID Embase Classic + Embase 1947 to 2019 May 31 (continued) Search Query Items Found #1 exp Peritoneal Dialysis/ 41740 #2 *dialysis, peritoneal/ 17899 #3 exp Continuous Ambulatory Peritoneal Dialysis/ 12442 #4 (Peritoneal Dialysis or Continuous Ambulatory Peritoneal Dialysis).tw,kw,rn. 32634 #5 (PD or CAPD or CCPD or APD or IPD or NIPD or TPD).tw,kw,rn. 217976 #6 or/1-5 246059 #7 exp Renin-Angiotensin System/ 38979 #8 ((Renin-Angiotensin System or RAS) adj (inhibitor* or blockade* or antagonist*)).tw. 3078 #9 Angiotensi*.tw. 136714 #10 or/7-9 148208 #11 6 and 10 2983 #12 exp Angiotensin-Converting Enzyme Inhibitors/ 167567 #13 ((Angiotensin-Converting Enzyme or Angiotensin I-Converting Enzyme or ACE or 46687 Kininase II) adj (inhibitor* or antagonist*)).tw. #14 (ACEI or ACEIs).tw,kw,rn 8374 #15 exp Benazepril/ 3485 #16 (Benazepril or Benezepril hydrochloride or Benazepril HCl, or Briem or Cibace or Cibacen 3360 or Cibacen CHF or Cibacene or Labopol or Lotensin or Lotrel or Tensanil or Zinadril or 86541-75-5).tw,kw,rn #17 exp Captopril/ 33873 #18 (Captopril or Acediur or Aceplus or Acepress or Acepril or Alopresin or Asisten or 35071 Captoten or Captolane or Captoprilum or Captopryl or Captoril or Cesplon or Dilabar or Farcopril or Garranil or Hypertil or Hypopress or Isopresol or L-Captopril or Lopirin or Lopril or Novocaptopril or Tenosbon or Tensoprel or Zapto or 62571-86-2).tw,kw,rn #19 exp Cilazapril/ 1938 #20 (Cilazapril or Dynorm or Inhibace or Vascace or 88768-40-5).tw,kw,rn 1972 #21 exp Delapril/ 425 #22 (Delapril or alindapril or Delaket or Adecut or Beniod or 83435-66-9).tw,kw,rn 435 #23 exp Enalapril/ 25551 #24 (Enalapril or Bonuten or Enalaprila or Enalaprilum or Gadopril or Kinfil or 75847-73- 28104 3).tw,kw,rn #25 exp Fosinopril/ 3029 #26 (Fosinopril or Dynacil or Fosenopril or Fosinil or Fosinorm or Fositens or Fozitec or 3091 Hiperlex or Monopril or Newace or Staril or Tenso Stop or Tensocardil or 98048-97- 6).tw,kw,rn #27 exp Imidapril/ 837 #28 (Imidapril or Tanatril or 89371-37-9).tw,kw,rn 848 #29 exp Lisinopril/ 15041 #30 (Lisinopril or Lisinopril dehydrate or Prinivil or Renacor or Zestril or 83915-83-7).tw,kw,rn 15340 #31 exp Moexipril/ 469 #32 (Moexipril or Univasc or 103775-10-6).tw,kw,rn 465 #33 exp Perindopril/ 8215 #34 (Perindopril or Aceon or Covapril or Coversyl or Pirindopril or Prestarium or 82834-16- 8600 0).tw,kw,rn #35 exp Quinapril/ 3418

S6 #36 (Quinapril or Quinapril hydrochloride or Quinapril HCl or Accupril or Accuprin or 3791 Accupron or Acequin or Acuitel or Acuprel or Asig or Conan or Continucor or Ectren or Hemokvin or Korec or Koretic or Lidaltrin or Quinazil or 85441-61-8).tw,kw,rn #37 exp Ramipril/ 13945 #38 (Ramipril or Acovil or Altace or Carasel or Cardace or Delix or Hytren or Lostapres or 14726 Naprix or Pramace or Quark or Ramace or Ramiprilum or Ramipro or Triatec or Tritace or Vesdil or Zabien or 87333-19-5).tw,kw,rn #39 exp Spirapril/ 375 #40 (Spirapril or Renormax or 83647-97-6).tw,kw,rn 378 #41 exp Temocapril/ 484 #42 (Temocapril or Temocaprilum or Acecol or 111902-57-9).tw,kw,rn 494 #43 exp Trandolapril/ 3201 #44 (Trandolapril or Gopten or Mavik or Odrik or Udrik or 87679-37-6).tw,kw,rn 3315 #45 exp Zofenopril/ 716 #46 (Zofenopril or Zocardis or 81872-10-8).tw,kw,rn 733 #47 or/12-46 176539 #48 6 and 47 2134 #49 exp Angiotensin Receptor Antagonists/ 85894 #50 exp Angiotensin II Type 1 Receptor Blockers/ 5457 #51 ((angiotensin or AT 2 receptor) adj3 (antagonist* or block*)).tw 27212 #52 (Sartan or Sartans).tw,kw,rn. 662 #53 (ARB or ARBs).tw,kw,rn. 13140 #54 exp Azilsartan/ 313 #55 (Azilsartan or Azilsartan medoxomil or Edarbi or 147403-03-0).tw,kw,rn. 497 #56 exp Candesartan/ 8571 #57 (Candesartan or Candesartan cilexetil or Amias or Atacand or Blopress or Ratacand or 9742 139481-59-7).tw,kw,rn. #58 exp Eprosartan/ 1621 #59 (Eprosartan or Teveten or 133040-01-4).tw,kw,rn. 1665 #60 exp Fimasartan/ 162 #61 (Fimasartan or Fimanta or Fimagen or Kanarb or 247257-48-3).tw,kw,rn. 146 #62 exp Irbesartan/ 7257 #63 (Irbesartan or Aprovel or Avapro or Karvea or 138402-11-6).tw,kw,rn. 7451 #64 exp Losartan/ 22257 #65 (Losartan or Cozaar or Losartan Monopotassium Salt or Lorsartan Potassium or 114798-26- 23975 4).tw,kw,rn. #66 exp Olmesartan/ 4399 #67 (Olmesartan or Olmesartan medoxomil or Benicar or Omesartan or Olmetec or Votum or 4633 144689-63-4).tw,kw,rn. #68 exp Tasosartan/ 103 #69 (Tasosartan or 145733-36-4).tw,kw,rn. 104 #70 exp Telmisartan/ 7397 #71 (Telmisartan or Kinzalmono or Micardis or Pritor or 144701-48-4).tw,kw,rn. 7632 #72 exp Valsartan/ 11322 #73 (Valsaetan or Diovan or Kalpress or Miten or Nisis or Provas or Tareg or Vals or Valtan or 10637 Valzaar or 137862-53-4).tw,kw,rn. #74 or/49-73 98676 #75 6 and 74 3014 #76 11 or 48 or 75 4498

S7 #77 exp Adolescent/ not (exp Adult/ and Adolescent/) 577082 #78 exp Child/ not (exp Adult/ and exp Child/) 2114974 #79 exp Infant/ not (exp Adult/ and exp Infant/) 882568 #80 or/77-79 2346557 #81 76 not 80 4186 #82 exp Animals/ not (Humans/ and exp Animals/) 13690117 #83 81 not 82 1768 #84 (comment or editorial or interview or letter or news or newspaper article).pt. 1671029 #85 83 not 84 1695 #86 randomized controlled trial/ or controlled clinical trial/ 738707 #87 exp "clinical trial (topic)"/ 294832 #88 (randomi#ed or randomly or RCT$1 or placebo*).tw,kw. 1274735 #89 ((singl* or doubl* or trebl* or tripl*) adj (mask* or blind* or dumm*)).tw,kw. 230600 #90 trial.ti. 279153 #91 controlled clinical trial/ 463093 #92 "controlled clinical trial (topic)" 10097 #93 (control* adj2 trial*).tw,kw. 331505 #94 or/86-93 1840966 #95 85 and 94 161 #96 (nRCT or nRCTs or non-RCT?).tw,kw. 1080 #97 (control* adj3 ("before and after" or "before after")).tw,kw. 5318 #98 time series analysis/ 23255 #99 (time series adj3 interrupt*).tw,kw. 3120 #100 pretest posttest control group design/ 388 #101 (pre- adj3 post-).tw,kw. 134025 #102 (pretest adj3 posttest).tw,kw. 5780 #103 controlled study/ 6692083 #104 (control* adj2 stud$3).tw,kw. 294277 #105 control group/ 123432 #106 (control* adj2 group$1).tw,kw. 681804 #107 or/96-106 7179243 #108 85 and 107 601 #109 exp comparative study/ 1361281 #110 ((comparative or comparison) adj (study or studies)).tw,kw. 141158 #111 exp cohort study/ 469974 #112 (cohort* adj2 stud$3).tw,kw. 296119 #113 exp case control study/ 158728 #114 ((case-control* or case-based or case-comparison) adj (study or studies)).tw,kw. 128213 #115 or/109-114 2107238 #116 85 and 115 93 #117 95 or 108 or 116 703

S8 Appendix 1. Systematic review search strategy: PubMed (From Inception to June 02, 2019) (continued) Search Query Items Found #1 ((((((Peritoneal Dialysis) OR Continuous Ambulatory Peritoneal Dialysis) OR Automated 31874 Peritoneal Dialysis) OR Continuous Cycling Peritoneal Dialysis) OR Intermittent Peritoneal Dialysis) OR Nocturnal Intermittent Peritoneal Dialysis) OR Tidal Peritoneal Dialysis #2 (((((((((((((((((Renin-Angiotensin System Inhibitors) OR Renin-Angiotensin System 755959 Blockade) OR Renin-Angiotensin System Antagonists) OR RAS inhibitor) OR RAS Blockade) OR RAS Antagonist) OR Angiotensin-Converting Enzyme Inhibitors) OR Angiotensin-Converting Enzyme Antagonists) OR ACE Inhibitor) OR ACE Antagonist) OR ACEI) OR ACEIs) OR Angiotensin Receptor Antagonists) OR Angiotensin II Type 1 Receptor Blockers) OR Angiotensin) OR AT 2 Receptor) OR ARB) OR ARBs #3 (((((((((((((((Benazepril) OR Captopril) OR Cilazapril) OR Delapril) OR Enalapril) OR 29703 Fosinopril) OR Imidapril) OR Lisinopril) OR Moexipril) OR Perindopril) OR Quinapril) OR Ramipril) OR Spirapril) OR Temocapril) OR Trandolapril) OR Zofenopril #4 (((((((((Azilsartan) OR Candesartan) OR Eprosartan) OR Fimasartan) OR Irbesartan) OR 19933 Losartan) OR Olmesartan) OR Tasosartan) OR Telmisartan) OR Valsartan #5 #2 OR #3 OR #4 760069 #6 #1 AND #5 613 #7 (((((((Case Reports[Publication Type]) OR Comment[Publication Type]) OR 6136775 Editorial[Publication Type]) OR Guideline[Publication Type]) OR Letter[Publication Type]) OR News[Publication Type]) OR Newspaper Article[Publication Type]) OR Review[Publication Type] #8 #6 NOT #7 471 #9 Filters: Humans 357

S9 Appendix 1. Systematic review search strategy: The Cochrane Library (From Inception to June 02, 2019) (continued) Search Query Items Found #1 ((((((Peritoneal Dialysis) OR Continuous Ambulatory Peritoneal Dialysis) OR Automated 2244 Peritoneal Dialysis) OR Continuous Cycling Peritoneal Dialysis) OR Intermittent Peritoneal Dialysis) OR Nocturnal Intermittent Peritoneal Dialysis) OR Tidal Peritoneal Dialysis #2 (((((((((((((((((Renin-Angiotensin System Inhibitors) OR Renin-Angiotensin System 54074 Blockade) OR Renin-Angiotensin System Antagonists) OR RAS inhibitor) OR RAS Blockade) OR RAS Antagonist) OR Angiotensin-Converting Enzyme Inhibitors) OR Angiotensin-Converting Enzyme Antagonists) OR ACE Inhibitor) OR ACE Antagonist) OR ACEI) OR ACEIs) OR Angiotensin Receptor Antagonists) OR Angiotensin II Type 1 Receptor Blockers) OR Angiotensin) OR AT 2 Receptor) OR ARB) OR ARBs #3 (((((((((((((((Benazepril) OR Captopril) OR Cilazapril) OR Delapril) OR Enalapril) OR 9854 Fosinopril) OR Imidapril) OR Lisinopril) OR Moexipril) OR Perindopril) OR Quinapril) OR Ramipril) OR Spirapril) OR Temocapril) OR Trandolapril) OR Zofenopril #4 (((((((((Azilsartan) OR Candesartan) OR Eprosartan) OR Fimasartan) OR Irbesartan) OR 7755 Losartan) OR Olmesartan) OR Tasosartan) OR Telmisartan) OR Valsartan #5 #2 OR #3 OR #4 61397 #6 #1 AND #5 134

S10 Appendix 1. Systematic review search strategy: Web of Science (From Inception to June 02, 2019) (continued) Search Query Items Found #1 TS=((((((Peritoneal Dialysis) OR Continuous Ambulatory Peritoneal Dialysis) OR 18299 Automated Peritoneal Dialysis) OR Continuous Cycling Peritoneal Dialysis) OR Intermittent Peritoneal Dialysis) OR Nocturnal Intermittent Peritoneal Dialysis) OR Tidal Peritoneal Dialysis #2 TS=((((((((((((((((((Renin-Angiotensin System Inhibitors) OR Renin-Angiotensin System 268088 Blockade) OR Renin-Angiotensin System Antagonists) OR RAS inhibitor) OR RAS Blockade) OR RAS Antagonist) OR Angiotensin-Converting Enzyme Inhibitors) OR Angiotensin-Converting Enzyme Antagonists) OR ACE Inhibitor) OR ACE Antagonist) OR ACEI) OR ACEIs) OR Angiotensin Receptor Antagonists) OR Angiotensin II Type 1 Receptor Blockers) OR Angiotensin) OR AT 2 Receptor) OR ARB) OR ARBs) #3 TS=((((((((((((((((Benazepril) OR Captopril) OR Cilazapril) OR Delapril) OR Enalapril) OR 16014 Fosinopril) OR Imidapril) OR Lisinopril) OR Moexipril) OR Perindopril) OR Quinapril) OR Ramipril) OR Spirapril) OR Temocapril) OR Trandolapril) OR Zofenopril) #4 TS=((((((((((Azilsartan) OR Candesartan) OR Eprosartan) OR Fimasartan) OR Irbesartan) 20778 OR Losartan) OR Olmesartan) OR Tasosartan) OR Telmisartan) OR Valsartan) #5 #2 OR #3 OR #4 283084 #6 #1 AND #5 415 #7 TS=((((((((((case reports) OR case series) OR comment) OR editorial) OR guideline) OR 86961 letter) meta-analysis) OR news) OR newspaper article) OR practical guideline) #8 #6 NOT #7 414

S11 Appendix 1. Systematic review search strategy: Scopus (From Inception to June 02, 2019) (continued) Search Query Items Found #1 ( TITLE-ABS-KEY ( peritoneal AND dialysis ) OR TITLE-ABS-KEY ( continuous 82103 AND ambulatory AND peritoneal AND dialysis ) OR TITLE-ABS-KEY ( automated AND peritoneal AND dialysis ) OR TITLE-ABS-KEY ( apd ) OR TITLE-ABS-KEY ( continuous AND cycling AND peritoneal AND dialysis ) OR TITLE-ABS-KEY ( ccpd ) OR TITLE-ABS-KEY ( intermittent AND peritoneal AND dialysis ) OR TITLE-ABS- KEY ( ipd ) OR TITLE-ABS-KEY ( nocturnal AND intermittent AND peritoneal AND dialysis ) OR TITLE-ABS-KEY ( nipd ) OR TITLE-ABS-KEY ( tidal AND peritoneal AND dialysis ) OR TITLE-ABS-KEY ( tpd ) ) #2 ( TITLE-ABS-KEY ( renin-angiotensin AND system AND inhibitors ) OR TITLE-ABS- 534787 KEY ( renin-angiotensin AND system AND blockade ) OR TITLE-ABS-KEY ( renin- angiotensin AND system AND antagonists ) OR TITLE-ABS-KEY ( ras AND inhibitor ) OR TITLE-ABS-KEY ( ras AND blockade ) OR TITLE-ABS-KEY ( ras AND antagonist ) OR TITLE-ABS-KEY ( angiotensin-converting AND enzyme AND inhibitors ) OR TITLE-ABS-KEY ( angiotensin-converting AND enzyme AND antagonists ) OR TITLE-ABS-KEY ( ace AND inhibitor ) OR TITLE-ABS-KEY ( ace AND antagonist ) OR TITLE-ABS-KEY ( acei ) OR TITLE-ABS-KEY ( aceis ) OR TITLE-ABS-KEY ( angiotensin AND receptor AND antagonists ) OR TITLE-ABS-KEY ( angiotensin AND ii AND type 1 receptor AND blockers ) OR TITLE-ABS-KEY ( angiotensin ) OR TITLE-ABS-KEY ( at 2 receptor ) OR TITLE-ABS-KEY ( arb ) OR TITLE-ABS-KEY ( arbs ) ) #3 ( TITLE-ABS-KEY ( benazepril ) OR TITLE-ABS-KEY ( captopril ) OR TITLE-ABS- 80933 KEY ( cilazapril ) OR TITLE-ABS-KEY ( delapril ) OR TITLE-ABS-KEY ( enalapril ) OR TITLE-ABS-KEY ( fosinopril ) OR TITLE-ABS-KEY ( imidapril ) OR TITLE- ABS-KEY ( lisinopril ) OR TITLE-ABS-KEY ( moexipril ) OR TITLE-ABS-KEY ( perindopril ) OR TITLE-ABS-KEY ( quinapril ) OR TITLE-ABS-KEY ( ramipril ) OR TITLE-ABS-KEY ( spirapril ) OR TITLE-ABS-KEY ( temocapril ) OR TITLE-ABS- KEY ( trandolapril ) OR TITLE-ABS-KEY ( zofenopril ) ) #4 ( TITLE-ABS-KEY ( azilsartan ) OR TITLE-ABS-KEY ( candesartan ) OR TITLE-ABS- 45105 KEY ( eprosartan ) OR TITLE-ABS-KEY ( fimasartan ) OR TITLE-ABS-KEY ( irbesartan ) OR TITLE-ABS-KEY ( losartan ) OR TITLE-ABS-KEY ( olmesartan ) OR TITLE-ABS-KEY ( tasosartan ) OR TITLE-ABS-KEY ( telmisartan ) OR TITLE-ABS- KEY ( valsartan ) ) #5 #2 OR #3 OR #4 588545 #6 #1 AND #5 1769 #7 ( ALL ( case AND reports ) OR ALL ( case AND series ) OR ALL ( comment ) OR 25067739 ALL ( editorial ) OR ALL ( guideline ) OR ALL ( letter ) OR ALL ( meta-analysis ) OR ALL ( news ) OR ALL ( newspaper AND article ) OR ALL ( practice AND guideline ) ) #8 #6 AND NOT #7 700

S12 Appendix 1. Systematic review search strategy: CINAHL (From Inception to June 02, 2019) (continued) Search Query Items Found #1 AB ((((((Peritoneal Dialysis) OR Continuous Ambulatory Peritoneal Dialysis) OR 8631 Automated Peritoneal Dialysis) OR Continuous Cycling Peritoneal Dialysis) OR Intermittent Peritoneal Dialysis) OR Nocturnal Intermittent Peritoneal Dialysis) OR Tidal Peritoneal Dialysis #2 AB (((((((((((((((((Renin-Angiotensin System Inhibitors) OR Renin-Angiotensin System 77320 Blockade) OR Renin-Angiotensin System Antagonists) OR RAS inhibitor) OR RAS Blockade) OR RAS Antagonist) OR Angiotensin-Converting Enzyme Inhibitors) OR Angiotensin-Converting Enzyme Antagonists) OR ACE Inhibitor) OR ACE Antagonist) OR ACEI) OR ACEIs) OR Angiotensin Receptor Antagonists) OR Angiotensin II Type 1 Receptor Blockers) OR Angiotensin) OR AT 2 Receptor) OR ARB) OR ARBs #3 AB (((((((((((((((Benazepril) OR Captopril) OR Cilazapril) OR Delapril) OR Enalapril) OR 10078 Fosinopril) OR Imidapril) OR Lisinopril) OR Moexipril) OR Perindopril) OR Quinapril) OR Ramipril) OR Spirapril) OR Temocapril) OR Trandolapril) OR Zofenopril #4 AB (((((((((Azilsartan) OR Candesartan) OR Eprosartan) OR Fimasartan) OR Irbesartan) 12076 OR Losartan) OR Olmesartan) OR Tasosartan) OR Telmisartan) OR Valsartan #5 S2 OR S3 OR S4 87294 #6 S1 AND S5 118

S13 Appendix 2. Grey literature from ongoing clinical trial register Trial registry Website Australia and New Zealand's (ANZCTR) http://www.anzctr.org.au Brazilian Clinical Trials Registry (ReBec) http://www.ensaiosclinicos.gov.br Chinese Clinical Trial Registry (ChiCTR) http://www.chictr.org.cn Clinical Research Information Service (CRiS), http://cris.cdc.go.kr Republic of Korea Clinical Trials Registry - India (CTRI) http://ctri.nic.in Cuban Public Registry of Clinical Trials(RPCEC) http://registroclinico.sld.cu EU Clinical Trials Register (EU-CTR) https://www.clinicaltrialsregister.eu/ German Clinical Trials Register (DRKS) http://www.drks.de Iranian Registry of Clinical Trials (IRCT) http://www.irct.ir/ Japan Primary Registries Network https://rctportal.niph.go.jp/ The Netherlands Trial Register http://www.trialregister.nl Pan African Clinical Trial Registry (PACTR) http://www.pactr.org/) Peruvian Registry of Clinical Trials http://www.ins.gob.pe/ensayosclinicos Philippine Health Research Registry http://registry.healthresearch.ph/ Sri Lanka Clinical Trials Registry (SLCTR) http://www.slctr.lk/ South African National Clinical Trials Register http://www.sanctr.gov.za Swiss FOPH Human Research Projects https://www.kofam.ch/en/swiss-clinical-trials- portal.html Tanzania Clinical Trial Registry http://www.tzctr.or.tz Thai Clinical Trials Registry http://www.clinicaltrials.in.th The United Kingdoms' ISRCTN registry http://www.isrctn.com The US National Institutes of Health Ongoing http://clinicaltrials.gov Trials Registry The World Health Organization International https://www.who.int/ictrp Clinical Trials Registry Platform (ICTRP)

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