OFF Exchange Drug Formulary, December 2015

Total Page:16

File Type:pdf, Size:1020Kb

OFF Exchange Drug Formulary, December 2015 UnitedHealthcare Prescription Drug List Please note: This Prescription Drug List(PDL) is accurate as of the date it was created and is subject to change after this date. Your estimated coverage and copay/co-insurance may vary based on the benefit plan you choose and the effective date of the plan. For additional details on specific medications, please refer to the drug search tool. Page Number ::1 Product Name Generic Name Benefit Prior Supply Step Specialty Tier Authorization Limit Therapy Medication 1ST BASE CRE *CREAM BASE** Tier 3 2-DEOXY-D POW -GLUCOSE 2-DEOXY-D-GLUCOSE POWDER Tier 4 8-MOP CAP 10MG METHOXSALEN CAP 10 MG Tier 2 A.A.G.C KIT CRE TERODERM *AMANTAD-AMITRIPT-GABA-CYCLOBEN CREAM 8- Tier 3 4-10-4% (CMPD KIT)** A/G PRO TAB *NUTRITIONAL SUPPLEMENT TABS** Tier 3 ABACAV/LAMIV TAB /ZIDOVUD ABACAV/LAMIV Tier 1 X ABACAVIR TAB 300MG ABACAVIR Tier 1 X ABILIFY SOL 1MG/ML ARIPIPRAZOLE ORAL SOLUTION 1 MG/ML Tier 4 ACAMPRO CAL TAB 333MG ACAMPRO CAL Tier 1 ACARBOSE TAB 100MG ACARBOSE Tier 1 ACARBOSE TAB 25MG ACARBOSE Tier 1 ACARBOSE TAB 50MG ACARBOSE Tier 1 ACCOLATE TAB 10MG ZAFIRLUKAST TAB 10 MG Tier 3 X ACCOLATE TAB 20MG ZAFIRLUKAST TAB 20 MG Tier 4 X ACCU-CHEK KIT FASTCLIX *LANCETS KIT*** Tier 1 ACCU-CHEK KIT MLTICLIX *LANCETS KIT*** Tier 1 ACCU-CHEK KIT SOFTCLIX *LANCETS KIT*** Tier 1 ACCU-CHEK LIQ ACT/GLUC *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACCU-CHEK LIQ COMPACT *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACCU-CHEK LIQ SMART *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACCU-CHEK MIS ADAPTER *INSULIN INFUSION PUMP - ACCESSORIES*** Tier 3 ACCU-CHEK MIS BATTERY *INSULIN INFUSION PUMP - ACCESSORIES*** Tier 3 ACCU-CHEK MIS CLIP *INSULIN INFUSION PUMP - ACCESSORIES*** Tier 3 ACCU-CHEK MIS MLTICLIX *LANCETS*** Tier 1 ACCU-CHEK MIS SPRT COM *INSULIN INFUSION PUMP - ACCESSORIES*** Tier 3 ACCU-CHEK SOL *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACCU-CHEK SOL COMFORT *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACCU-CHEK SOL COMPACT *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACCU-CHEK IN LIQ CONTROL *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACCUPRIL TAB 10MG QUINAPRIL HCL TAB 10 MG Tier 4 ACCUPRIL TAB 20MG QUINAPRIL HCL TAB 20 MG Tier 4 ACCUPRIL TAB 40MG QUINAPRIL HCL TAB 40 MG Tier 4 ACCUPRIL TAB 5MG QUINAPRIL HCL TAB 5 MG Tier 4 ACCURETIC TAB 10-12.5 QUINAPRIL-HYDROCHLOROTHIAZIDE TAB 10-12.5 Tier 4 MG ACCURETIC TAB 20-12.5 QUINAPRIL-HYDROCHLOROTHIAZIDE TAB 20-12.5 Tier 4 MG ACCURETIC TAB 20-25MG QUINAPRIL-HYDROCHLOROTHIAZIDE TAB 20-25 MG Tier 4 ACCUTREND SOL GLUCOSE *BLOOD GLUCOSE CALIBRATION - LIQUID*** Tier 1 ACD/FLUORIDE DRO 0.25MG ACD/FLUORIDE Tier 1 ACE ACD/ALUM SOL 2% OTIC ACE ACD/ALUM Tier 1 ACEBUTOLOL CAP 200MG ACEBUTOLOL Tier 1 ACEBUTOLOL CAP 400MG ACEBUTOLOL Tier 1 ACEON TAB 4MG PERINDOPRIL ERBUMINE TAB 4 MG Tier 4 ACEON TAB 8MG PERINDOPRIL ERBUMINE TAB 8 MG Tier 4 ACETASOL HC SOL OTIC HYDROCORTISONE W/ ACETIC ACID OTIC SOLN 1- Tier 2 2% ACETAZOLAMID CAP 500MG ER ACETAZOLAMID Tier 1 ACETAZOLAMID TAB 125MG ACETAZOLAMID Tier 1 ACETAZOLAMID TAB 250MG ACETAZOLAMID Tier 1 ACETIC ACID SOL 2% OTIC ACETIC ACID Tier 1 ACETYLCYST SOL 10% ACETYLCYST Tier 1 ACETYLCYST SOL 20% ACETYLCYST Tier 1 ACITRETIN CAP 10MG ACITRETIN Tier 1 ACITRETIN CAP 17.5MG ACITRETIN Tier 1 ACITRETIN CAP 25MG ACITRETIN Tier 1 ACLOVATE CRE 0.05% ALCLOMETASONE DIPROPIONATE CREAM 0.05% Tier 3 ACTICIN CRE 5% ACTICIN Tier 1 ACTIGALL CAP 300MG URSODIOL CAP 300 MG Tier 4 ACTIMMUNE INJ 2MU/0.5 INTERFERON GAMMA-1B INJ 100 MCG/0.5ML Tier 2 X X X (2000000 UNIT/0.5ML) ACTIVE MEDIC KIT SPECIMEN ACTIVE MEDIC Tier 1 Page Number ::2 Product Name Generic Name Benefit Prior Supply Step Specialty Tier Authorization Limit Therapy Medication ACTIVE OB CAP *PRENATAL W/O A W/FE CBN-FA-DHA CAP 20-1-320 Tier 3 MG*** ACTIVELLA TAB 0.5-0.1 ESTRADIOL & NORETHINDRONE ACETATE TAB 0.5- Tier 4 0.1 MG ACTIVELLA TAB 1-0.5MG ESTRADIOL & NORETHINDRONE ACETATE TAB 1-0.5 Tier 4 MG ACTIVE-PREP CRE KIT I *FLURBIPROFEN-CYCLOBENZAPRINE CREAM Tier 3 (CMPD KIT)*** ACTIVE-PREP CRE KIT II *KETOPROFEN-BACLOFEN-GABAPENTIN CREAM Tier 3 (CMPD KIT)*** ACTIVE-PREP CRE KIT III *KETOPROFEN-LIDOCAINE-GABAPENTIN CREAM Tier 3 (CMPD KIT)*** ACTIVE-PREP CRE KIT IV *TRAMADOL-GABAPENTIN-MENTHOL-CAMPHOR Tier 3 CREAM (CMPD KIT)*** ACTIVE-PREP CRE KIT V *ITRACONAZOLE-PHENYTOIN SODIUM CREAM Tier 3 (CMPD KIT)*** ACTONEL TAB 150MG RISEDRONATE SODIUM TAB 150 MG Tier 4 X ACTONEL TAB 30MG RISEDRONATE SODIUM TAB 30 MG Tier 4 ACTONEL TAB 35MG RISEDRONATE SODIUM TAB 35 MG Tier 4 X ACTONEL TAB 5MG RISEDRONATE SODIUM TAB 5 MG Tier 4 ACTOPLUS MET TAB 15-500MG PIOGLITAZONE HCL-METFORMIN HCL TAB 15-500 Tier 4 X MG ACTOPLUS MET TAB 15-850MG PIOGLITAZONE HCL-METFORMIN HCL TAB 15-850 Tier 4 X MG ACTOPLUS MET TAB XR PIOGLITAZONE HCL-METFORMIN HCL TAB SR 24HR Tier 3 X 15-1000 MG ACTOPLUS MET TAB XR PIOGLITAZONE HCL-METFORMIN HCL TAB SR 24HR Tier 3 X 30-1000 MG ACULAR SOL 0.5% OP KETOROLAC TROMETHAMINE OPHTH SOLN 0.5% Tier 4 ACULAR LS SOL 0.4% KETOROLAC TROMETHAMINE OPHTH SOLN 0.4% Tier 4 ACUNOL TAB 600MG *HOMEOPATHIC PRODUCTS - TAB** Tier 3 ACYCLOVIR CAP 200MG ACYCLOVIR Tier 1 ACYCLOVIR SUS 200/5ML ACYCLOVIR Tier 1 ACYCLOVIR TAB 400MG ACYCLOVIR Tier 1 ACYCLOVIR TAB 800MG ACYCLOVIR Tier 1 ADALAT CC TAB 30MG ER NIFEDIPINE TAB SR 24HR 30 MG Tier 4 ADALAT CC TAB 60MG ER NIFEDIPINE TAB SR 24HR 60 MG Tier 4 ADALAT CC TAB 90MG ER NIFEDIPINE TAB SR 24HR 90 MG Tier 4 ADAPTADERM CRE *CREAM BASE** Tier 3 ADAPTADERM GEL *GEL BASE - GEL** Tier 3 ADASUVE INH 10MG LOXAPINE AEROSOL POWDER BREATH ACTIVATED Tier 3 10 MG ADDERALL XR CAP 10MG AMPHETAMINE-DEXTROAMPHETAMINE CAP SR Tier 2 X 24HR 10 MG ADDERALL XR CAP 15MG AMPHETAMINE-DEXTROAMPHETAMINE CAP SR Tier 2 X 24HR 15 MG ADDERALL XR CAP 20MG AMPHETAMINE-DEXTROAMPHETAMINE CAP SR Tier 2 X 24HR 20 MG ADDERALL XR CAP 25MG AMPHETAMINE-DEXTROAMPHETAMINE CAP SR Tier 2 X 24HR 25 MG ADDERALL XR CAP 30MG AMPHETAMINE-DEXTROAMPHETAMINE CAP SR Tier 2 X 24HR 30 MG ADDERALL XR CAP 5MG AMPHETAMINE-DEXTROAMPHETAMINE CAP SR Tier 2 X 24HR 5 MG ADEFOV DIPIV TAB 10MG ADEFOV DIPIV Tier 1 X ADEMPAS TAB 0.5MG RIOCIGUAT TAB 0.5 MG Tier 2 X X X ADEMPAS TAB 1.5MG RIOCIGUAT TAB 1.5 MG Tier 2 X X X ADEMPAS TAB 1MG RIOCIGUAT TAB 1 MG Tier 2 X X X ADEMPAS TAB 2.5MG RIOCIGUAT TAB 2.5 MG Tier 2 X X X ADEMPAS TAB 2MG RIOCIGUAT TAB 2 MG Tier 2 X X X ADRENALIN INJ 1MG/ML EPINEPHRINE INJ 1 MG/ML (1:1000) Tier 3 ADRENALIN SOL 1:1000 EPINEPHRINE HCL NASAL SOLN 0.1% Tier 2 ADV LANCING MIS DEVICE *LANCET DEVICES*** Tier 3 ADVAIR DISKU AER 100/50 FLUTICASONE-SALMETEROL AER POWDER BA 100- Tier 3 X 50 MCG/DOSE ADVAIR DISKU AER 250/50 FLUTICASONE-SALMETEROL AER POWDER BA 250- Tier 3 X 50 MCG/DOSE ADVAIR DISKU AER 500/50 FLUTICASONE-SALMETEROL AER POWDER BA 500- Tier 3 X 50 MCG/DOSE Page Number ::3 Product Name Generic Name Benefit Prior Supply Step Specialty Tier Authorization Limit Therapy Medication ADVAIR HFA AER 115/21 FLUTICASONE-SALMETEROL INHAL AEROSOL 115- Tier 3 X 21 MCG/ACT ADVAIR HFA AER 230/21 FLUTICASONE-SALMETEROL INHAL AEROSOL 230- Tier 3 X 21 MCG/ACT ADVAIR HFA AER 45/21 FLUTICASONE-SALMETEROL INHAL AEROSOL 45-21 Tier 3 X MCG/ACT ADVANCED BAS CRE PLUS *CREAM BASE** Tier 3 ADVANCED DNA KIT COLLECTI ADVANCED DNA Tier 1 ADVATE INJ 1000UNIT ANTIHEMOPHILIC FACTOR RAHF-PFM FOR INJ 1000 Tier 2 X UNIT ADVATE INJ 1500UNIT ANTIHEMOPHILIC FACTOR RAHF-PFM FOR INJ 1500 Tier 2 X UNIT ADVATE INJ 2000UNIT ANTIHEMOPHILIC FACTOR RAHF-PFM FOR INJ 2000 Tier 2 X UNIT ADVATE INJ 250UNIT ANTIHEMOPHILIC FACTOR RAHF-PFM FOR INJ 250 Tier 2 X UNIT ADVATE INJ 3000UNIT ANTIHEMOPHILIC FACTOR RAHF-PFM FOR INJ 3000 Tier 2 X UNIT ADVATE INJ 4000UNIT ANTIHEMOPHILIC FACTOR RAHF-PFM FOR INJ 4000 Tier 2 X UNIT ADVATE INJ 500UNIT ANTIHEMOPHILIC FACTOR RAHF-PFM FOR INJ 500 Tier 2 X UNIT ADVERA LIQ CHOCOLAT *NUTRITIONAL SUPPLEMENT LIQUID** Tier 3 ADVERA LIQ VANILLA *NUTRITIONAL SUPPLEMENT LIQUID** Tier 3 AERCHMBR PLS MIS FLOW-VU *SPACER/AEROSOL-HOLDING CHAMBERS - Tier 3 DEVICE*** AERCHMBR PLS MIS LRG MASK *SPACER/AEROSOL-HOLDING CHAMBERS - Tier 3 DEVICE*** AERCHMBR PLS MIS SM MASK *SPACER/AEROSOL-HOLDING CHAMBERS - Tier 3 DEVICE*** AERO OTIC HC SOL AERO OTIC HC Tier 1 AEROCHAMBER MIS PLUS *SPACER/AEROSOL-HOLDING CHAMBERS - Tier 3 DEVICE*** AEROSPAN AER 80MCG FLUNISOLIDE HFA INHAL AEROSOL 80 MCG/ACT Tier 3 X AFEDITAB TAB 30MG CR AFEDITAB Tier 1 AFEDITAB TAB 60MG CR AFEDITAB Tier 1 AFINITOR TAB 10MG EVEROLIMUS TAB 10 MG Tier 2 X X X AFINITOR TAB 2.5MG EVEROLIMUS TAB 2.5 MG Tier 2 X X X AFINITOR TAB 5MG EVEROLIMUS TAB 5 MG Tier 2 X X X AFINITOR TAB 7.5MG EVEROLIMUS TAB 7.5 MG Tier 2 X X X AFINITOR DIS TAB 2MG EVEROLIMUS TAB FOR ORAL SUSP 2 MG Tier 2 X X X AFINITOR DIS TAB 3MG EVEROLIMUS TAB FOR ORAL SUSP 3 MG Tier 2 X X X AFINITOR DIS TAB 5MG EVEROLIMUS TAB FOR ORAL SUSP 5 MG Tier 2 X X X AFTERA TAB 1.5MG AFTERA Tier 1 AGGRENOX CAP 25-200MG ASPIRIN-DIPYRIDAMOLE CAP SR 12HR 25-200 MG Tier 3 AGRYLIN CAP 0.5MG ANAGRELIDE HCL CAP 0.5 MG Tier 4 AIF #2 DRUG CRE PREP KIT AIF #2 DRUG Tier 1 AIF #3 DRUG CRE PREP KIT *FLURBIPROFEN-BACLOFEN-CYCLOBEN-LIDO Tier 3 CREAM (CMP KIT)** AIRSHIELD TAB *SPECIALITY VITAMIN PRODUCT EFFER TAB** Tier 3 AKNE-MYCIN OIN 2% ERYTHROMYCIN OINT 2% Tier 2 AK-POLY-BAC OIN OP AK-POLY-BAC Tier 1 AKTEN GEL 3.5% LIDOCAINE HCL OPHTH GEL 3.5% Tier 3 AKYNZEO CAP NETUPITANT-PALONOSETRON CAP 300-0.5 MG Tier 4 X ALA SCALP LOT 2% HYDROCORTISONE LOTION 2% Tier 4 ALAGESIC LQ SOL ALAGESIC LQ Tier 1 X ALA-QUIN CRE 3-0.5% ALA-QUIN Tier 1 ALBA-DERM CRE *CREAM BASE** Tier 3 ALBATUSSIN CAP PHENYLEPHRINE-CARBETAPENTANE-GG CAP 10-25- Tier 3 400 MG ALBATUSSIN LIQ NN *PHENYLEPH-DM-PYRIL-POT GUAI-SOD CIT-CIT Tier 2 ACID LIQUID*** ALBENZA TAB 200MG
Recommended publications
  • Wachter-Et-Al-LSM-32(2003)101-110.Pdf
    Lasers in Surgery and Medicine 32:101–110 (2003) Topical Rose Bengal: Pre-Clinical Evaluation of Pharmacokinetics and Safety 1 1 1 1 2 Eric Wachter, PhD, * Craig Dees, PhD, Jay Harkins, Timothy Scott, PhD, Mark Petersen, DVM, 3 4 Rusty E. Rush, MS, and Amy Cada, PhD 1Provectus Pharmaceuticals, Inc., Knoxville, Tennessee 37931 2College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37916 3Springborn Laboratories, Inc., Spencerville, Ohio 45887 4Therimmune Research Corporation, Gaithersburg, Maryland 20879 Background and Objectives: Rose bengal (RB) is a should have minimal potential for side effects, such as potent photosensitizer that has largely been overlooked as a prolonged photosensitivity. potential photodynamic therapy (PDT) agent. In this study, Since RB readily photobleaches [29], its photodynamic the feasibility of topical delivery of RB to the epidermis has effects may be self-limiting. This is particularly relevant for been evaluated. treatment of many dermatologic conditions, such as psoria- Study Design/Materials and Methods: Topical formu- sis and actinic keratosis, since precise light dosimetry is lations of RB were assessed on murine and rabbit skin for impractical over the large surface areas typically involved pharmacokinetic properties, cutaneous toxicity, and photo- in these diseases: a PDT regimen that exhibits self-limiting sensitization. effects would avoid the need for complex light dosimetry. Results: Hydrophilic formulations (1% RB) exhibited The combination of photodynamic potential, substantial
    [Show full text]
  • (12) United States Patent (10) Patent N0.: US 8,343,962 B2 Kisak Et Al
    US008343962B2 (12) United States Patent (10) Patent N0.: US 8,343,962 B2 Kisak et al. (45) Date of Patent: *Jan. 1, 2013 (54) TOPICAL FORMULATION (58) Field of Classi?cation Search ............. .. 514/226.5, 514/334, 420, 557, 567 (75) Inventors: Edward T. Kisak, San Diego, CA (US); See application ?le fOr Complete Search history. John M. NeWsam, La Jolla, CA (US); _ Dominic King-Smith, San Diego, CA (56) References C‘ted (US); Pankaj Karande, Troy, NY (US); Samir Mitragotri, Goleta, CA (US) US' PATENT DOCUMENTS 5,602,183 A 2/1997 Martin et al. (73) Assignee: NuvoResearchOntano (CA) Inc., Mississagua, 6,328,979 2B1 12/2001 Yamashita et a1. 7,001,592 B1 2/2006 Traynor et a1. ( * ) Notice: Subject to any disclaimer, the term of this 7,795,309 B2 9/2010 Kisak eta1~ patent is extended or adjusted under 35 2002/0064524 A1 5/2002 Cevc U.S.C. 154(b) by 212 days. FOREIGN PATENT DOCUMENTS This patent is subject to a terminal dis- W0 WO 2005/009510 2/2005 claimer- OTHER PUBLICATIONS (21) APPI' NO‘, 12/848,792 International Search Report issued on Aug. 8, 2008 in application No. PCT/lB2007/0l983 (corresponding to US 7,795,309). _ Notice ofAlloWance issued on Apr. 29, 2010 by the Examiner in US. (22) Med Aug- 2’ 2010 Appl. No. 12/281,561 (US 7,795,309). _ _ _ Of?ce Action issued on Dec. 30, 2009 by the Examiner in US. Appl. (65) Prior Publication Data No, 12/281,561 (Us 7,795,309), Us 2011/0028460 A1 Feb‘ 3’ 2011 Primary Examiner * Raymond Henley, 111 Related U 5 Application Data (74) Attorney, Agent, or Firm * Foley & Lardner LLP (63) Continuation-in-part of application No.
    [Show full text]
  • Ophthalmic Herpes Zoster
    OPHTHALMIC HERPES ZOSTER RONALD J. MARSH and MATTHEW COOPER London SUMMARY Fig. 1 shows the age and sex distribution, which is A current review of ophthalmic zoster is presented biased in favour of females and compares with 50.7% including its virology, immunology, epidemiology and males, 49.3% females in another series.5 The 1981 census pathogenesis. We give our findings in 1356 patients for Greater London recorded 48% males and 52% referred to the Zoster Clinic at Moorfields Ey e Hospital, females. London. The treatment of the disease and its ocular com­ ONSET plications is discussed. There is a prodromal influenza-like illness of varying Ophthalmic herpes zoster is a disease varying in severity duration, with headache, pyrexia, malaise, depression, and from devastating, threatening life and sight, to so mild that sometimes neck stiffness, which may last up to a week it may pass unnoticed. The ophthalmic division of the fifth before the rash appears. This is shortly followed by local­ cranial nerve is affected in 7-17.5% of herpes zoster ised pain over the distribution of the ophthalmic nerve, patients. 1-5 Ocular involvement complicates approxi­ lymph node swelling in the corresponding drainage areas mately 50% of these cases and very rarely cases of maxil­ and, occasionally, a red eye. The localised pain is well lary herpes zoster,l affecting many of the tissues of the known to precede the rash by several days in some cases. globe and orbit by highly varied types of lesions. This probably represents the replication and migration We felt it would be helpful to report our experience with phase of the disease and is possibly accompanied by a lim­ the disease because the large number of cases we have ited viraemia.
    [Show full text]
  • Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
    Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate.
    [Show full text]
  • Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study
    Cornea Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study Patricia Gallego-Munoz,˜ 1 Luc´ıa Ibares-Fr´ıas,1 Elvira Lorenzo,1 Susana Marcos,2 Pablo Perez-Merino,´ 2 Nandor Bekesi,2 Irene E. Kochevar,3 and M. Carmen Mart´ınez-Garc´ıa1 1Departamento de Biolog´ıa Celular, Histolog´ıa y Farmacolog´ıa, GIR de Tecnicas´ Opticas´ para el Diagnostico,´ Universidad de Valladolid, Valladolid, Spain 2Instituto de Optica,´ Consejo Superior de Investigaciones Cient´ıficas, Madrid, Spain 3Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States Correspondence: M. Carmen PURPOSE. To evaluate corneal wound healing after treatment with a new collagen crosslinking Mart´ınez-Garc´ıa, Departamento de protocol using rose bengal dye and green light (RGX). Biolog´ıa Celular, Histolog´ıa y Farm- acolog´ıa, Facultad de Medicina, Uni- METHODS. One cornea of 20 New Zealand rabbits was de-epithelialized (DE) in an 8-mm versidad de Valladolid, C/Ramon´ y diameter circle and, in another group (n ¼ 25), the DE corneas were then stained with 0.1% Cajal 7, 47005 Valladolid, Spain; rose bengal for 2 minutes and exposed to green light (532 nm) for 7 minutes (RGX). The mariacarmen.martinez.garcia@ contralateral eyes without treatment acted as controls. The animals were clinically followed uva.es. including fluorescein staining and pachymetry. Healing events were analyzed after euthanasia 0 Submitted: December 23, 2016 at 2, 30, and 60 days. Cell death (TUNEL assay), cell proliferation (5-bromo-2 -deoxyuridine Accepted: June 1, 2017 incorporation), and cell differentiation to myofibroblasts (a-SMA labeling) were carried out.
    [Show full text]
  • PF 44(1) Table of Contents Publish Date: November 1, 2017
    PF 44(1) Table of Contents Publish date: November 1, 2017 PROPOSED IRA: Proposed Interim Revision Announcements USP MONOGRAPHS IN-PROCESS REVISION: In-Process Revision GENERAL NOTICES FOR USP-NF General Notices to USP-NF (USP42-NF37) 1. TITLE AND REVISION 2. OFFICIAL STATUS AND LEGAL RECOGNITION 3. CONFORMANCE TO STANDARDS 4. MONOGRAPHS AND GENERAL CHAPTERS 5. MONOGRAPH COMPONENTS 6. TESTING PRACTICES AND PROCEDURES 7. TEST RESULTS 8. TERMS AND DEFINITIONS 9. PRESCRIBING AND DISPENSING 10. PRESERVATION, PACKAGING, STORAGE, AND LABELING GENERAL CHAPTERS <7> LABELING (USP42-NF37) <561> ARTICLES OF BOTANICAL ORIGIN (USP42-NF37) <1057> BIOTECHNOLOGY-DERIVED ARTICLES—TOTAL PROTEIN ASSAY (USP42-NF37) <1160> PHARMACEUTICAL CALCULATIONS IN PHARMACY PRACTICE (USP42-NF37) <1176> PRESCRIPTION BALANCES AND VOLUMETRIC APPARATUS USED IN COMPOUNDING (USP42- NF37) REAGENTS, INDICATORS, AND SOLUTIONS Reagent Specifications Aflatoxin B1 [NEW] (USP42-NF37) Aflatoxin B2 [NEW] (USP42-NF37) Aflatoxin G1 [NEW] (USP42-NF37) Aflatoxin G2 [NEW] (USP42-NF37) Clozapine N-Oxide [NEW] (USP42-NF37) Deuterated Ethanol [NEW] (USP42-NF37) Deuterium Chloride Solution [NEW] (USP42-NF37) Deuterium Oxide (USP42-NF37) Isobutyl Chloroformate [NEW] (USP42-NF37) PF 4x(x) Table of Contents 1 | P a g e Polyethylene Glycol 400 [NEW] (USP42-NF37) Polyethylene Glycol 4000 [NEW] (USP42-NF37) Pyridine, Anhydrous [NEW] (USP42-NF37) Trifluoroacetic Acid Ethyl Ester [NEW] (USP42-NF37) Test Solutions Citric Acid TS [NEW] (USP42-NF37) Sodium Chloride TS [NEW] (USP42-NF37) Volumetric Solutions
    [Show full text]
  • Curable Composition and Skin Adhesive
    (19) TZZ ¥Z¥_T (11) EP 2 957 303 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 23.12.2015 Bulletin 2015/52 A61L 15/58 (2006.01) A61L 24/04 (2006.01) C08K 5/10 (2006.01) C09J 167/06 (2006.01) (2006.01) (21) Application number: 14173247.9 C08L 67/06 (22) Date of filing: 20.06.2014 (84) Designated Contracting States: (72) Inventor: Schüwer, Nicolas AL AT BE BG CH CY CZ DE DK EE ES FI FR GB 1010 Lausanne (CH) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (74) Representative: Hoffmann Eitle Designated Extension States: Patent- und Rechtsanwälte PartmbB BA ME Arabellastraße 30 81925 München (DE) (71) Applicant: NITTO DENKO CORPORATION Osaka 567 (JP) (54) Curable composition and skin adhesive (57) The present invention pertains to compositions The composition of the invention may be cross- linked to containing a polycondensate and optionally an oil com- yield an adhesive composition. The composition of the ponent, wherein the polycondensate is derived from a invention and the adhesive composition of the invention dicarboxylic acid component, a diol component and an may be used on substrates such as tapes and patches ethylenically unsaturated dicarboxylic acid component. in the medical field. EP 2 957 303 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 957 303 A1 Description 1. Technical Field of the Invention 5 [0001] The present invention relates to a curable composition comprising: a polycondensate of a dicarboxylic acid, a diol, and a polymerizable ethylenic derivative; and optionally an oil additive.
    [Show full text]
  • Medications in Pregnant and Nursing Mothers
    Medications in Pregnant and Nursing Mothers NADINE M. GIRGIS, OD, FAAO ASSISTANT PROFESSOR YIN C. TEA, OD, FAAO CHIEF, PEDIATRICS AND BINOCULAR VISION ASSISTANT PROFESSOR Gestation age vs fetal age Gestation age-sperm penetrates the egg and zygote is formed Zygote (fertilized egg) travels from fallopian tube to uterus During this time, egg divides into cells - called a morula Continued dividing and morula - called a blastocyst - embeds in the uterus anywhere from 6-12 days after conception This begins the embryonic stage and fetal age begins Fetal development-1st trimester Gestation age week 3-fetal age week 1: a lot of basic growth Brain, spinal cord, heart, GI tract begin development 1st trimester Gestation age-week 4 and 5: embryo ¼ inch long Arm and leg buds, ears, eyes forming Placenta forming and producing hormones Heart is beating at a steady rhythm Movement of rudimentary blood through blood vessels 1st trimester Gestation age week 6: embryo is ½ in length Lungs, jaw, nose, plate formation, hands and feet Hand and feet buds have webbed structures Brain forming into complex parts 1st trimester Gestation age week 7: weighs less than an aspirin All essential organs have begun to form Hair, nail follicles, eyelids and tongue starting to form Trunk begins to straighten out 1st trimester Gestation age week 8: 1 in long, size of a bean All parts of adult are now present in the embryo Bones beginning to form Muscles begin to contract Facial features, including eyelids more developed Gestation age weeks 9-13: 3 in and weighs
    [Show full text]
  • Waste Disposal Guide
    Waste Disposal Guide How to Properly Dispose of Waste Materials Generated at Michigan State University Environmental Health & Safety (EHS) / Office of Radiation, Chemical & Biological Safety (ORCBS) C124 Research Complex‐Engineering East Lansing, MI 48824‐1326 Revised April 2009 CONTACT INFORMATION Campus Emergency: 911 ORCBS Phone Number: (517) 355-0153 ORCBS Fax Number: (517) 353-4871 ORCBS E-mail Address: [email protected] ORCBS Web Address: http://www.orcbs.msu.edu TABLE OF CONTENTS Sections Introduction ................................................................................................................... 4 Hazardous Waste Defined ............................................................................................ 5 Requirements for Chemical Waste ............................................................................... 6 Classification of Chemical Waste .................................................................................. 7 Containers ..................................................................................................................... 8 Container Label ............................................................................................................. 9 General Labeling & Packaging Procedures .................................................................. 9 Specific Labeling & Packaging Procedures ............................................................. 9-15 Scheduling a Chemical Waste Pick-up ......................................................................
    [Show full text]
  • Inhibition of Vesicular Glutamate Storage and Exocytotic Release by Rose Bengal
    Journal of Neurochemistry, 2001, 77,34±42 Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal Kiyokazu Ogita,*,1 Koji Hirata,* David G. Bole,* Sumiko Yoshida,*,2 Yutaka Tamura,*,3 Anne Marie Leckenby* and Tetsufumi Ueda*,²,³ *Mental Health Research Institute, Departments of ²Pharmacology and ³Psychiatry, Medical School, The University of Michigan, Ann Arbor, Michigan, USA Abstract the synaptosome result in a corresponding decrease in the It had been thought that quantal size in synaptic transmission amount of [3H]Glu released in a depolarization- (induced by 4- is invariable. Evidence has been emerging, however, that aminopyridine) and Ca21-dependent manner. In contrast, quantal size can be varied under certain conditions. We ¯uorescein, the halogen-free analog of Rose Bengal, which is 3 3 present evidence that alteration in vesicular [ H]L-glutamate devoid of inhibitory activity on vesicular [ H]Glu uptake, failed to (Glu) content within the synaptosome (a pinched-off nerve change the amount of exocytotically released [3H]Glu. These ending preparation) leads to a change in the amount of observations suggest that glutamate synaptic transmission exocytotically released [3H]Glu. We found that Rose Bengal, a could be altered by pharmacological intervention of glutamate polyhalogenated ¯uorescein derivative, is a quite potent uptake into synaptic vesicles in the nerve terminal, a new membrane-permeant inhibitor (K 19 nM) of glutamate mode of synaptic manipulation for glutamate transmission. i uptake into isolated synaptic vesicles. This vesicular Glu Keywords: glutamate, inhibitor, release, Rose Bengal, uptake inhibition was achieved largely without affecting H1- vesicular uptake. pump ATPase. We show that various degrees of reduction J.
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]
  • 2020 Aetna Standard Plan
    Plan for your best health Aetna Standard Plan Aetna.com Aetna is the brand name used for products and services provided by one or more of the Aetna group of subsidiary companies, including Aetna Life Insurance Company and its affiliates (Aetna). Aetna Pharmacy Management refers to an internal business unit of Aetna Health Management, LLC. Aetna Pharmacy Management administers, but does not offer, insure or otherwise underwrite the prescription drug benefits portion of your health plan and has no financial responsibility therefor. 2020 Pharmacy Drug Guide - Aetna Standard Plan Table of Contents INFORMATIONAL SECTION..................................................................................................................6 *ADHD/ANTI-NARCOLEPSY/ANTI-OBESITY/ANOREXIANTS* - DRUGS FOR THE NERVOUS SYSTEM.................................................................................................................................16 *ALLERGENIC EXTRACTS/BIOLOGICALS MISC* - BIOLOGICAL AGENTS...............................18 *ALTERNATIVE MEDICINES* - VITAMINS AND MINERALS....................................................... 19 *AMEBICIDES* - DRUGS FOR INFECTIONS.....................................................................................19 *AMINOGLYCOSIDES* - DRUGS FOR INFECTIONS.......................................................................19 *ANALGESICS - ANTI-INFLAMMATORY* - DRUGS FOR PAIN AND FEVER............................19 *ANALGESICS - NONNARCOTIC* - DRUGS FOR PAIN AND FEVER.........................................
    [Show full text]