Insight from NLP Analysis: COVID-19 Vaccines Sentiments on Social Media

Total Page:16

File Type:pdf, Size:1020Kb

Insight from NLP Analysis: COVID-19 Vaccines Sentiments on Social Media Insight from NLP Analysis: COVID-19 Vaccines Sentiments on Social Media Tao Na∗, Wei Cheng∗, Dongming Li∗, Wanyu Lu∗, Hongjiang Li∗ ∗Department of Computer Science, University of Manchester, Manchester, UK Correspondence to: Tao Na <[email protected]> Each author has equal contribution Abstract—Social media is an appropriate source for analyzing 2 December 2020 [4], in the US on 12 December 2020 [5] and public attitudes towards the COVID-19 vaccine and various in the EU on 21 December 2020 [6]. At the time of writing, brands. Nevertheless, there are few relevant studies. the availability of the COVID-19 vaccine is still limited, and In the research, we collected tweet posts by the UK and US residents from the Twitter API during the pandemic and designed less than 6% of the global population has received the vaccine. experiments to answer three main questions concerning vaccina- As of 20 March 2021, vaccination coverage in the UK and US tion. To get the dominant sentiment of the civics, we performed was 43.99% and 36.31%, respectively [7]. sentiment analysis by VADER and proposed a new method that The development of a safe vaccine through animal models can count the individual’s influence in. This allows us to go a step of RSV can take up to thirty years [8]. Vaccine development further in sentiment analysis and explain some of the fluctuations in the data changing. The results indicated that celebrities could needs to be evaluated repeatedly in animal models before lead the opinion shift on social media in vaccination progress. putting into clinical trials. Because of the severity of the Moreover, at the peak, nearly 40% of the population in both epidemic, the development pace of new crown vaccines is countries have a negative attitude towards COVID-19 vaccines. unprecedented. Each country and global organization have Besides, we investigated how people’s opinions toward different lowered relevant criteria for new COVID-19 vaccines, and they vaccine brands are. We found that Pfizer vaccine enjoys the most popular among people. By applying the sentiment analysis have also shortened the clinical trials of vaccines [9]. Although tool, we discovered most people hold positive views toward the the vaccines now in use have undergone rigorous testing and COVID-19 vaccine manufactured by most brands. In the end, review to ensure safety, many people remain skeptical about we carried out topic modelling by using the LDA model. We the safety of the vaccines. There are small parts of people who found residents in the two countries are willing to share their even refused to be vaccinated with the COVID-19 vaccine. views and feelings concerning the vaccine. Several death cases have occurred after vaccination. Due to these negative events, US In order to promote the vaccine effectively, it is undoubtedly residents are more worried about the side effects and safety of significant to collect people’s opinions toward the vaccine and the vaccine. its side effects. However, measures such as social isolation, Index Terms—Natural Language Processing, COVID-19, Vac- quarantine and travel restrictions imposed by governments cine, UK, US, Sentiment analysis, Topic modelling, Social media, have hindered the collection process. Therefore social media, Text mining like Twitter, becomes the ideal source of data. To investigate the perceptions and attitudes of the UK I. INTRODUCTION and US citizens regarding the vaccine, we used the twitter Since the first patient was identified in Wuhan, China, in API to collect relevant tweets during the outbreak. And we December 2019 [1], the COVID-19 has spread rapidly to conducted social media analysis on these tweets. The dataset Europe and eventually worldwide. COVID-19 can cause severe was collected by using the Twitter API. Based on a public respiratory illness [2]. This complication has caused more than dataset1 provided by Banda et al. [10], we only kept tweet id arXiv:2106.04081v1 [cs.CL] 8 Jun 2021 2.17 million deaths. An outbreak of the virus has also been column of the English twitter posts with the location limitation spreading in the UK and the US since March 2020. As of 22 to the US and the UK. And then we downloaded all COVID- March 2021, the number of confirmed cases in both countries 19 vaccine-related tweets from the twitter stream via twitter exceeded 29.8 million and 4.3 million. COVID-19 has killed API and the tweet ids. The public messages, like tweet id, more than 668,000 people in the two countries. date, time, lang and country place are included in our final To prevent further spread of COVID-19 and relieve the dataset. The usage of dataset fully compliant with Twitter’s enormous medical pressure, the development and promotion terms of service. of vaccines are crucial. Several pharmaceutical companies Three main questions we analyze in this paper about and universities have been working on COVID-19 vaccines COVID-19 vaccine and our contribution to each question are at an unprecedented rate. More than 260 possible COVID- as shown below: 19 vaccines have been proposed, but only a few have been • What is the dominant sentiment towards COVID-19 approved. Several others are in state-of-the-art steps of testing vaccines? For this question, We provide the analysis [3]. Pfizer is the first international pharmaceutical company to have its vaccine approved in multiple countries: in the UK on 1Public dataset: https://zenodo.org/record/4603998#.YGGK3GQzb0q 1 about the attitude of citizens locating in the UK and US questions: First, such an approach requires a considerable toward the COVID-19 vaccine. The analysis is mainly amount of tagged emotional vocabulary data that is often chal- conducted using a sentiment analysis tool, VADER [11], lenging to obtain towards a particular text-domain. Second, the which is used primarily to explore the main sentiment deep model is Computational extensive in training, validation expressed in people’s tweets. In the research, we also and testing, and the model’s performance in predicting tasks proposed a new method that can capture the user’s public directly limit its ability to process streaming data. Third, such influence on the social network, thus contributing to the deep models are usually of the black box type, with limited analysis of experiments result. interpretability. • Which COVID-19 vaccine brands/manufacturers have Because of the advantages of VADER, it has a wide range been most talked about recently? Do people prefer of applications. Toni Pano and Rasha Kashef [18] researched any brands? Regarding to this, we explore the sentiment if outbreaks of COVID-19 can influence Bitcoin prices. They of people locating in the UK and US toward different performed 13 different strategies for BTC tweets. VADER COVID-19 vaccine brands. We manually determined vac- scoring systems are regarded as the optimum processing cine brands and corresponding keywords that are cur- approach. Mohapatra et al. [19] had attempted to assign each rently talked most about on the Twitter platform. VADER tweet a compound sentiment score based on the VADER is used to analyze people’s preferences regarding different sentiment analysis algorithm. The number of Twitter followers, brands. number of likes, and number of retweets associated with each • What people concern about the COVID-19 vaccine? tweet is used for the final sentiment score. What are the popular topics regarding vaccines? With Three-level hierarchical Bayesian model, Latent Dirichlet respect to this issue, we identified the main concerns Allocation(LDA), is generative probabilistic model for finding among citizens about the COVID-19 vaccine. Using the patterns of words in text corpus [20]. LDA is demonstrated that LDA model, we explored the popular topics from the it outperforms batch variational bayes (VB) and also need less perspective of time series, country and sentiment, respec- running time [21]. The performance of classical state space tively. models and specify a statistical model of topic evolution has been enhanced by David et al. [22]. Based on probabilistic II. RELATED WORK time series, this dynamic model can capture the evolution of Sentiment analysis, also called opinion mining, aims to topics in a corpus. One of LDA limitations is the incompetence evaluate embedded attitudes, opinions, sentiments, evaluations to model topic correlation. [23] has presented the correlated via the computational subjectivity in natural language text topic model(CTM) with respect to this limitation. The CTM di- [11]. Through sentiment analysis, we can know whether a text rectly models correlation between topics by using co-variance has a positive or negative subjective orientation. structure among the components. This proved correlation play Common sentiment analysis models rely heavily on senti- an important role in topic modelling. In [24], key words ment dictionaries. A sentiment lexicon is a set of vocabulary are used to represent topics. Automatic coherence evaluation in which each word is labelled according to the positivity and was proposed to rate coherence or interpretability. Michael et negativity of its subjective orientation. al. [25] proposed a framework that combines existing word- Separately, the different lexicons can be classified into two based coherence measures and the combinations of basic types: semantic orientation labelling (divided into positive or components. This configuration space has explored the best negative) or more fine-grained quantitative scoring with pre- overall correlation for the coherence definition with respect to defined rules. LIWC [12], GI [13], HU-LIU04 [14] are widely all available human topic ranking data. used polarity-based lexicons in which words are context-free. In contrast, ANEW [15], SentiWordNet [16] and SenticNet III. METHODOLOGY [17] are based on sentiment intensity thus could conduct a A. Overview quantitative scoring evaluation. The VADER (Valence Aware Dictionary for Sentiment Rea- Firstly, we collect the tweets data from a public Twitter sonable) proposed by C.J.
Recommended publications
  • Updated May 26, 2021 Cross-Border Industry Partnerships on COVID-19 Vaccines and Therapeutics Vaccines • Curevac O Celonic Wi
    Updated May 26, 2021 Cross-Border Industry Partnerships on COVID-19 Vaccines and Therapeutics Vaccines • CureVac o Celonic will manufacture 100 million doses of CureVac’s vaccine at its plant in Heidelberg, Germany, providing bulk substance for 50 million doses by the end of 2021. (press release) o Novartis will manufacture CureVac’s vaccine. (press release) o GlaxoSmithKline plc and CureVac N.V. announced a new €150m collaboration, building on their existing relationship, to jointly develop next generation mRNA vaccines for COVID-19 with the potential for a multi-valent approach to address multiple emerging variants in one vaccine. (press release) o Rentschler Biopharma SE will manufacture CureVac’s vaccine. (press release) o Bayer will support the further development, supply and key territory operations of CureVac’s vaccine candidate. (press release) o Fareva will dedicate a manufacturing plant in France to the fill and finish of CureVac’s vaccine. (press release) o Wacker Chemie AG will manufacture CureVac’s vaccine candidate at its Amsterdam site. (press release) o CureVac will collaborate with Tesla Grohmann Automation to develop an RNA printer that works like a mini-factory and can produce such drugs automatically. (press release) • Moderna o Samsung Biologics will provide large scale, commercial fill-finish manufacturing for Moderna’s vaccine in South Korea. (press release) o Baxter International will provide fill/finish services and supply packaging for Moderna. (press release) o Sanofi will manufacture 200 million doses of Moderna’s COVID-19 vaccine starting in September 2021. (press release) o Rovi will produce bulk substance for Moderna’s COVID-19 vaccine, expanding an agreement between the companies.
    [Show full text]
  • Curevac Announces Financial Results for the Second Quarter and First Half of 2021 and Provides Business Update
    CureVac Announces Financial Results for the Second Quarter and First Half of 2021 and Provides Business Update Continuation of corporate transformation into commercial-ready biopharma company o Management team strengthened with appointments of Chief Operating Officer Malte Greune and Chief Development Officer Klaus Edvardsen First-generation COVID-19 vaccine candidate, CVnCoV o Final analysis reported of pivotal Phase 2b/3 study conducted in ten countries in variant-dominated environment o Committed to seeking regulatory approval with EMA – submission of comprehensive clinical data packages within rolling submission ongoing Second-generation COVID-19 vaccine candidate, CV2CoV, jointly advanced with GSK o Preclinical study provides evidence for strongly improved immune responses with second-generation mRNA backbone compared to first-generation backbone during challenge study and against range of variants, including Delta and Lambda variant o Start of CV2CoV Phase 1 clinical trial anticipated in Q4 2021 Oncology Programs o Phase 1 trial extension of lead asset, CV8102, on track to fully recruit o Legacy program, BI 1361849, developed in partnership with Boehringer Ingelheim, based on early protamine formulation terminated; companies assessing options for further collaboration Financials: Cash position of €1.36 billion as of June 30, 2021 TÜBINGEN, Germany/ BOSTON, USA – August 16, 2021 – CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced financial results for the second quarter and first half of 2021 and provided business update. “Large parts of the world are still under-vaccinated against SARS-CoV-2, making effective vaccines necessary to prevent further evolution of the virus and to avoid renewed restrictions on public life,” said Franz-Werner Haas, Chief Executive Officer of CureVac.
    [Show full text]
  • J&J Provides Early Hope for Single-Dose Covid-19 Vaccine
    January 14, 2021 J&J provides early hope for single-dose Covid-19 vaccine Madeleine Armstrong Pivotal data for JNJ-78436735 are imminent, with Novavax and Curevac not far behind. One advantage of Johnson & Johnson’s Covid-19 vaccine candidate is that it might provide protection after a single dose. Early neutralising antibody data suggest that this might indeed be the case – but, as ever, this needs to be confirmed with efficacy data. Luckily, that is coming very soon: results from the Ensemble trial, testing one dose of JNJ-78436735, are due in late January. Other projects from Novavax and Curevac are also set to yield pivotal data in the first quarter, so it might soon become clear whether more vaccines will be joining the currently authorised options. Selected upcoming readouts with Covid-19 vaccines Vaccine Company Trial name/details N Trial ID Timing name Ensemble, US ph3, single 45,000 NCT04505722 Data due Jan 2021 Johnson & JNJ- dose Johnson 78436735 Ensemble-2, US ph3, two 30,000 NCT04614948 Began Nov 2020 doses Data due early Q1 S Africa ph2b 4,400 NCT04533399 2021 NVX- Data due early Q1 Novavax UK ph3 15,000 NCT04583995 CoV2373 2021 Interim data due Q2 Prevent-19, US/Mexico ph3 30,000 NCT04611802 2021 Herald, Europe ph2/3 36,500 NCT04652102 Data due Q1 2021 CVnCoV Curevac Europe ph3, healthcare Primary completion 2,500 NCT04674189 workers Jun 2021 Primary completion Astrazeneca AZD1222* US ph3 30,000 NCT04516746 Mar 2021 *Authorised in the UK in Dec 2020. Source: EvaluatePharma & clinicaltrials.gov. The latest data came from a phase I/II trial of JNJ-78436735, and were published in the NEJM yesterday; these are updated results from a preprint released in September.
    [Show full text]
  • Nanomedicines to Deliver Mrna: State of the Art and Future Perspectives
    nanomaterials Review Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives Itziar Gómez-Aguado , Julen Rodríguez-Castejón ,Mónica Vicente-Pascual , Alicia Rodríguez-Gascón , María Ángeles Solinís * and Ana del Pozo-Rodríguez * Pharmacokinetics, Nanotechnology & Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de investigación Lascaray ikergunea, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain; [email protected] (I.G.-A.); [email protected] (J.R.-C.); [email protected] (M.V.-P.); [email protected] (A.R.-G.) * Correspondence: [email protected] (M.Á.S.); [email protected] (A.d.P.-R.); Tel.: +34-945013469 (M.Á.S.); +34-945014498 (A.d.P.-R.) Received: 31 January 2020; Accepted: 16 February 2020; Published: 20 February 2020 Abstract: The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its unique features compared to plasmid DNA: Transient expression, no need to enter into the nucleus and no risk of insertional mutagenesis. Nevertheless, the clinical application of mRNA as a therapeutic tool is limited by its instability and ability to activate immune responses; hence, mRNA chemical modifications together with the design of suitable vehicles result essential. This manuscript includes a revision of the strategies employed to enhance in vitro transcribed (IVT) mRNA functionality and efficacy, including the optimization of its stability and translational efficiency, as well as the regulation of its immunostimulatory properties. An overview of the nanosystems designed to protect the mRNA and to overcome the intra and extracellular barriers for successful delivery is also included.
    [Show full text]
  • Curevac Raises a Total of USD 640 Million in Private Financing Round
    CureVac Raises a Total of USD 640 Million in Private Financing Round Financing Round includes previously announced investments from German Federal Government and GSK for an amount of USD 514 million Additional USD 126 million raised, including participation of Qatar Investment Authority (QIA) TÜBINGEN, Germany/ BOSTON – July 21, 2020 – CureVac AG, a clinical-stage biopharmaceutical company developing a new class of transformative medicines based on optimized mRNA, today announced the closing of its latest private financing round, raising a total of USD 640 million (560 million Euros). The financing round included previously announced equity investments by the German government via the Kreditanstalt für Wiederaufbau (KfW) with USD 343 million and GSK with USD 171 million as well as additional new equity investments from Qatar Investment Authority (QIA) and a group of existing and new investors with approximately USD 126 million. About CureVac’s mRNA technology platform CureVac’s mRNA technology platform has shown potential in the development and production of mRNA based vaccines and therapeutics. CureVac’s RNAoptimizer platform aims to optimize the properties of mRNA medicines based on its three core pillars: protein design, mRNA optimization and mRNA delivery. The technology can be tailored to induce varying degrees of immune responses against specific protein antigens of choice, potentially providing potent prophylactic vaccines for the prevention of infectious diseases, such as Rabies, as well as immunotherapies for the treatment of cancer. The technology can also be adapted to avoid immune activation for purposes of protein therapy and antibodies, thereby providing potential new therapeutic modalities for patients suffering from a vast range of diseases.
    [Show full text]
  • Curevac COVID Vaccine Let-Down Spotlights Mrna Design Challenges
    6/21/2021 CureVac COVID vaccine let-down spotlights mRNA design challenges NEWS 18 June 2021 CureVac COVID vaccine let-down spotlights mRNA design challenges Scientists are searching for explanations to disappointing final-stage trial results. These insights could help guide the future development of mRNA vaccines. Elie Dolgin A trial volunteer in Belgium recieves a dose of CureVac's vaccine. Credit: Yves Herman/Reuters/Alamy Two vaccines made using messenger RNA (mRNA) have proved spectacularly successful at warding off COVID-19, but a third mRNA-based candidate has flopped https://www.nature.com/articles/d41586-021-01661-0 1/6 6/21/2021 CureVac COVID vaccine let-down spotlights mRNA design challenges in a final-stage trial, according to an initial report released this week. Researchers are now asking why — and some think that choices about the type of mRNA chemistry used might be to blame. Any insight could help to guide the future design of mRNA vaccines against COVID-19 or other diseases. The company behind the beleaguered trial, CureVac, based in Tübingen, Germany, announced preliminary data on 16 June from a 40,000-person trial, which showed that its two-dose vaccine was just 47% effective at preventing disease. CureVac’s mRNA vaccine was expected to be cheaper RELATED and to last longer in refrigerated storage than the earlier mRNA vaccines made by Pfizer–BioNTech and Moderna. Many had hoped that it could help to expand the reach of mRNA-based vaccines in lower-income Six months of COVID countries, and European countries were expecting to vaccines: what 1.7 billion order hundreds of millions of doses.
    [Show full text]
  • Opportunities and Challenges in the Delivery of Mrna-Based Vaccines
    pharmaceutics Review Opportunities and Challenges in the Delivery of mRNA-Based Vaccines Abishek Wadhwa , Anas Aljabbari , Abhijeet Lokras , Camilla Foged and Aneesh Thakur * Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark; [email protected] (A.W.); [email protected] (A.A.); [email protected] (A.L.); [email protected] (C.F.) * Correspondence: [email protected]; Tel.: + 45-3533-3938; Fax: +45-3533-6001 Received: 28 December 2019; Accepted: 26 January 2020; Published: 28 January 2020 Abstract: In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, therapeutic protein replacement therapies, and treatment of genetic diseases. However, challenges that impede the successful translation of these molecules into drugs are that (i) mRNA is a very large molecule, (ii) it is intrinsically unstable and prone to degradation by nucleases, and (iii) it activates the immune system. Although some of these challenges have been partially solved by means of chemical modification of the mRNA, intracellular delivery of mRNA still represents a major hurdle. The clinical translation of mRNA-based therapeutics requires delivery technologies that can ensure stabilization of mRNA under physiological conditions. Here, we (i) review opportunities and challenges in the delivery of mRNA-based therapeutics with a focus on non-viral delivery systems, (ii) present the clinical status of mRNA vaccines, and (iii) highlight perspectives on the future of this promising new type of medicine.
    [Show full text]
  • Curevac Emerges with €35M Cancer Vaccine Endorsement
    September 18, 2014 CureVac emerges with €35m cancer vaccine endorsement Jacob Plieth It looks like Germany’s CureVac just emerged from stealth mode. Today’s oncology deal with Boehringer Ingelheim comes hot on the heels of July’s tie-up with Sanofi Pasteur, seemingly justifying the faith of venture capitalists who pumped a massive $99m into a series D round in 2012. Perhaps most surprising is the fact that Boehringer is endorsing not only CureVac’s technology, but also its application as a cancer vaccine – an area notorious for disappointment. The deal focuses on a naked mRNA vaccine through the design of which CureVac thinks it can overcome earlier failures. The concept is simple enough: deliver mRNA to cells of the immune system, leading to expression of target proteins and triggering an immune response against tumour cells. This is theoretically safer than delivering DNA, which is able to integrate into the host genome and can thus lead to unwanted side effects that are difficult to reverse. But in practice, although mRNA delivery has been shown to induce significant protein expression, the approach has been hampered by the inherent instability of mRNA and its rapid degeneration in the body. CureVac, however, claims to have got around this by modifying the mRNA sequence to stabilise the molecule, as well as raising its immunogenicity by complexing it with protamine, a small nuclear protein. This work came from Tübingen University, from which the company was spun out in 2000 (EP Vantage Interview – CureVac hoping for continued support from guardian angel, December 11, 2009). However, beyond some major VC funding and the backing of one Dietmar Hopp, until recently CureVac had little in terms of hard industry validation.
    [Show full text]
  • Curevac Announces Financial Results and Business Updates for the Fourth Quarter and Full-Year of 2020
    CureVac Announces Financial Results and Business Updates for the Fourth Quarter and Full-Year of 2020 COVID-19 vaccine candidate: CVnCoV in final stage of clinical development and believed to be well on track to provide data for conditional approval based on EMA rolling submission o Pivotal Phase 2b/3 in Europe and Latin America fully recruited with over 40,000 participants. Interim analysis for vaccine efficacy expected in Q2 2021 o Phase 2a trial in Peru and Panama amended for addition of secondary endpoint for vaccine efficacy in total population with a focus on participants over the age of 60 CVnCoV demonstrates, in preclinical challenge study, full protection from infections with Variant of Concern B.1.351 (South Africa variant) Expanding COVID-19 vaccine program: Three new CVnCoV studies in specific populations expected to be initiated soon Advancing the commercial organization and preparing access to commercial territories Expanded manufacturing network with European partners expected to manufacture up to 300 million doses of CVnCoV by end of 2021 and up to one billion doses in 2022 Partnerships with Bayer, GSK and the UK government (partnership under final discussions) to rapidly advance first-generation vaccines and expand into second-generation vaccines in our COVID-19 program Oncology lead asset CV8102: Phase 1 expansion cohort initiated with preferred dose in patients with advanced melanoma Financials: o Cash position of €1.32 billion as of December 31, 2020 o Additional $517.5 million in gross proceeds based on issuance of 5,750,000 common shares from February 2021 capital raise TÜBINGEN, Germany/ BOSTON, USA – April 15, 2021 – CureVac N.V.
    [Show full text]
  • Vaccine Manufacturing Collaborations
    WORKING TOGETHER TO FIGHT COVID-19: VACCINE MANUFACTURING COLLABORATIONS Across the industry, biopharmaceutical companies are working around the clock to meet the demands of COVID-19 vaccine manufacturing. Companies are working to source needed raw materials and other supplies and increasing manufacturing capacity to get COVID-19 vaccine shots in as many arms as possible. Even prior to knowing the efficacy of particular vaccine candidates, companies have proactively been increasing their own manufacturing capabilities as well as partnering with other manufacturers who are sharing available capacity to support production. These partnerships have been key to manufacturing ramp-up following vaccine authorization. MANUFACTURING PROCESS Manufacturing vaccines on a global scale is a highly specialized and intensive bioprocess given that COVID-19 vaccines are complex biologic products. At a high level, the manufacturing process falls into six critical phases and biopharmaceutical companies are lending a hand at every step: Raw Material Active Coupling & Packaging & Shipment & Filling Reception Ingredient Formulation Lot Releases Distribution RECENT EXAMPLES OF PhRMA MEMBER Bayer COMPANY VACCINE MANUFACTURING Bayer and CureVac are partnering to manufacture CureVac’s COLLABORATIONS INCLUDE: mRNA-based COVID-19 vaccine. Bayer will contribute its expertise and established infrastructure in areas such as clinical operations, regulatory affairs, pharmacovigilance, medical information and AstraZeneca supply chain performance as well as support in selected
    [Show full text]
  • CRISPR Therapeutics and Casebia Collaborate with Curevac on Mrna for Gene-Editing Programs
    CRISPR Therapeutics and Casebia Collaborate with CureVac on mRNA for Gene-Editing Programs November 13, 2017 CureVac’s mRNA technology accessed to express Cas9 for in vivo liver-targeted therapies ZUG, Switzerland and CAMBRIDGE, Mass. and TÜBINGEN, Germany, and BOSTON, Nov. 13, 2017 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (NASDAQ:CRSP), a genome editing company focused on creating transformative gene-based medicines for serious diseases, Casebia Therapeutics, a joint-venture established by CRISPR Therapeutics and Bayer AG for developing CRISPR-based therapeutics in select disease areas, and CureVac AG, a biopharmaceutical company pioneering mRNA-based drugs, today announced they have signed a collaboration agreement. Under the terms of the agreement, CureVac will develop novel Cas9 mRNA constructs with improved properties for gene editing applications, such as increased potency, decreased duration of expression, and reduced potential for immunogenicity. CRISPR Therapeutics and Casebia have obtained an exclusive license to the improved constructs for use in three of their in vivo gene-editing programs in liver diseases. CureVac will also provide mRNA manufacturing through clinical development and commercialization of the three programs. In exchange, CureVac will receive an upfront payment and research funding, and will be eligible to receive development and commercial milestones and royalties on commercialized products arising from the collaboration. “This collaboration with CRISPR Therapeutics demonstrates the breadth of CureVac’s RNArt® technology and its potential in the field of genome editing,” stated Dan Menichella, CBO of CureVac AG and CEO of CureVac Inc. “With this collaboration we have the opportunity to combine CRISPR’s cutting-edge genome editing technology with CureVac’s mRNA expertise to potentially deliver transformative therapies to patients.” Samarth Kulkarni, Ph.D., President and CBO of CRISPR Therapeutics commented, “Enabling in vivo CRISPR-based therapies is a strategic priority for CRISPR.
    [Show full text]
  • Genmab and Curevac Enter Strategic Partnership to Develop Mrna-Based Antibody Therapeutics
    Genmab and CureVac Enter Strategic Partnership to Develop mRNA-based Antibody Therapeutics Company Announcement Genmab and CureVac enter broad strategic partnership Companies to conduct joint research on first program; option for Genmab to initiate three additional programs during 5-year research term Genmab will provide CureVac with a USD 10 million upfront payment and make an equity investment in CureVac of 20 million euro CureVac eligible to receive milestones between USD 275 million and USD 368 million for each of the potential product candidates, depending on specific product concept Copenhagen, Denmark and Tübingen, Germany, December 19, 2019 – Genmab A/S (Nasdaq: GMAB) and CureVac AG announced today that Genmab and CureVac have entered into a research collaboration and license agreement. This strategic partnership will focus on the research and development of differentiated mRNA-based antibody products by combining CureVac’s mRNA technology and know-how with Genmab’s proprietary antibody technologies and expertise. “As part of Genmab’s effort to fundamentally transform cancer treatment we have once again entered into a collaboration that will further provide us with the potential to lead innovation in the antibody space,” said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. “CureVac’s unique mRNA technology, which uses the body’s own ability to produce specific proteins from nucleic acid, combined with Genmab’s world-class antibody expertise and robust proprietary technology platforms could create multiple novel options for the treatment of patients with cancer.” “We are delighted to partner with Genmab. Through our agreement focused on mRNA encoding antibodies, we will continue to demonstrate the robustness of our mRNA technology,” said Daniel L.
    [Show full text]