A Review on Genus Vitex-A Novel Medicinal Plant R Devika Department of Biotechnology, Aarupadai Veedu Institute of Technology, Paiyanoor-603 104, India
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Int J Pharma Res Health Sci. 2017; 5 (6): 1904-08 DOI:10.21276/ijprhs.2017.06.01 R Devika CODEN (USA)-IJPRUR, e-ISSN: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Review Article A Review on Genus Vitex-A Novel Medicinal Plant R Devika Department of Biotechnology, Aarupadai Veedu Institute of Technology, Paiyanoor-603 104, India. ARTICLE INFO ABSTRACT Received: 12 Nov 2017 Plants produces various kinds of chemicals through metabolism (Primary Accepted: 10 Dec 2017 and Secondary) which play an important role in growth of the plant and act as a defensive material. These compounds are recognized as essential nutrients for normal physiological functions. Recent researches demonstrate that these compounds protect human against diseases in various actions such as antioxidants, hormonal action, anti-microbial and even in physical actions. The genus Vitex is evident of many phytochemicals which is therapeutic values. Key words:Therapeutic, medicinal, efficacy, phytochemical, verbenaceae ______ 1. INTRODUCTION Plant metabolites are used traditionally to treat various chronic and infectious diseases1. WHO stated 80% of World’s population depends on the traditional medicine for their primary health care and immediate remedy2,3. Phytochemicals are the major source of antimicrobial drugs which form the major alternative traditional medicine for various diseases4,5. Folk knowledge and preexisting plant data evaluated and scientific research on phytochemistry, biology and pharmacological activities revealed several discoveries and investigations on drug discovery6,7. Several Corresponding author * R Devika researches on plant metabolites revealed antimicrobial Department of Biotechnology, activities6,8,9 against wide range of drug resistant Aarupadai Veedu Institute of Technology, Paiyanoor-603 104 10,11 12 13 india. bacteria , anti-cancer , anti-hepatotoxic . WHO report E-mail: [email protected] 1904 IIIIIIIII© International Journal of Pharma Research and Health Sciences. All rights reserved Int J Pharma Res Health Sci. 2017; 5 (6): 1904-08 estimated around 21,000 plants have been used for medicinal V. negundo is wide spread (Table 5) and the various parts purposes and out of which 500 higher plants are recognized have remedy procedures (Table 6).The Vitex negundo plant as potential source of drugs14and it was also reported that has been proved to be highly therapeutic for many around 119 pure phytochemical are extracted from 90 plant centuries35 for many aliment such as snake venom species15. The major phytochemicals are used as neutralization36, analgesic37, nitric oxide scavenging pharmaceuticals, agrochemicals, flavours, fragrance, food activity38, hepatoprotective39, antifungal40, anti- additives, insecticides, pesticides etc. 14,16. lipopaeroxidative41and diabetic42(Table:7) Vitex is a genus of flowering plants17 of family Laminaceae PHYTOCHEMICALS OF VITEX consisting of 250 species 18,19 and commonly known as The crude extracts of leaves registered the presence of “Chaste tree” 20 and they are native of Tropical and alkaloids, flavonoids, terpenoids, steroids, phenolics, Subtropical countries21 and the Sanskrit synonyms is carbohydrates and amino acids43,.44 The therapeutic values of tabulated in Table 1. The genus vitexis an erect21 shrub or phytochemicals are tabulated in the Table 724. The HPLC small tree growing upto 2 to 8 m height. Leaves are digitate results of leaves and the barks of Vitex leucoxylon reported with five lanceolate or sometimes three leaflets (4 to 10 cm to contain febrifuge, β- stiesterol, dimethyl terphthalate, in length). The leaf edges are toothed or serrated with hairy vitexin, isovitexin, agnuside, ancubin45.Vitex eltissima leaves bottom 6,7. White or blue flowers borne in panicles (10 – 20 are efficient as antibacterial40and against mosquitoes. The cm in length) with petals of different lengths (middle lower phytochemicals registered in V. negundo leaves18 were lobe being longer). Corolla and calyx are covered with dense hydroxyl-3,6,7,3’,4’- penta methoxyflavone46, 6’ p- hairs8(Table 2).Vitexnegundo is indigenous to the countries hydroxybenzoyl mussaenosidic acid, 5’3’ dihydroxybenzoic like Malaysia, Vietnam, Myanmar, Nepal, Pakistan, acid, flavonoids, p-hydroxymethyl-7-methoxy-3,4-dihydro- Philippines, Sri Lanka, Taiwan, China, India, Korea, Kenya, 2-napthaldehyde46. The bioactive compounds of roots of Bhutan etc. The botanical classification of vitex is tabulated V.negundo were vitrofial, vitaxin and isovitexin, acetyl in Table 317 and the vernacular names of the genus vitex are oleanolic acid, lyoniresinol47. tabulated (Table 4)26. VITEX AS PESTICIDES AND LARVICIDES From ancient times genus Vitex leaves are scientifically 2. MEDICINAL VALUES OF GENUS proved to be effective pesticides against coleopteran pests VITEX such as Callosbruchus chinensis, Rhyzoptha dominica, 26 Traditionally, the extracts of the roots, fruits, flowers and Sitophilus oryzae, Stophilus zeaais, Latheticus oryzae etc. leaves of genus vitex were used externally and internally. Combination of essential oil of Vitex and Citronella oil was 39 The decoction of leaves is used for steam bath for arthritis, very efficient against Sitotroga cerealella . Leaf and joint pain, scialica22. The smoke of dry leaves are useful for branches showed highest repellency against insects and pests 6. headaches, sinusitis and common cold24. Nirgundi oil is best of paddy, Euproctis fraternal and Spodoptera litura The for dry cleaning of wounds, anti-infective and to remove foul petroleum ether leaf extracts revealed highest larvicidal smell25. The word vitexis derived from ‘Vieo’ (Latin) which effect against Culex tritaeniorhynchus in the laboratory means tie or bind and out of 270 known species 18 are in condition and these acted as a detterent against the mosquito 27,48 regular cultivation as crops and they are called ‘Chaste Aedes aewgypti . The phytochemicals such as alkaloids tree’26. Vitex trifolia is a abundant in Southeastern Asia and and glycosides in the leaves of Vitex proved to have high 2 Melanesia with three leaves commonly known as Indian germicidal activity . 2-hepatricontanone from leaf extracts of Privet or Indian wild-pepper27. Vitex trifolia is also known as Vitex inhibits the oviposition of stored grain boring insects 13 ‘Pani-Ki-Sanbhala’ and ‘Sufed-Sanbhalu’ in Hindi and like S. corealella, R. dominica and S. oryzae . ‘Langunding-Dagal’ in Philippines28. The other species Vitex negundo Linn.proved to be an efficient novel 44 found in seashore upto the altitude of 1,500 m are V. plant against fungi, virus, larva, feedent, bacteria etc . Vitex negundo, V.glabrata, V. leucoxylon, V. penducularis, negundo Linn. proved to be highly insecticidal against V.pinnata in India and they are abundant on sandy solids29. Phthorimaeo aperudella, Allosobruches maculates,Aphis 7 V. nirgundi is believed to be scared as it has been originated citricola, A. gossypii, Myzus passicae and act as the best from the abdomen of Ganadhipa (an appellation of Lord larvicidal against Anapheles subpictus, Culex Shiva and also from Ganesha)30 and the leaves are offered to tritaeniophnchus, C quinquefasciatus, Anapheles stephensi. both Lord Shiva and Godress Gowri during Nitya Samavara Vitex sps. Act as anti-feedant, anti-filarial and anti-fungal 49 Vrata31. against Alternaria alternat , Curvularia lunata, From ancient times,V. trifolia along with anthill acted as the Trichophyton mentagrophytes, Cryptococcus neoformans, 50 indicator for the presence of tasteful water in the Aspergillus nigerand Candida albicans . ground32,33and V. negundo was used as totem plant during war, wherein the soldiers wore the flowers of nocci (V. 3. CONCLUSION negundo) and it referred Sindhuvara as bad omen for any The genus Vitex consists of various bioactive components army camp34. The commercial utility of the various parts of which are of medicinal value. These bioactive compounds 1905 IIIIIIIII© International Journal of Pharma Research and Health Sciences. All rights reserved Int J Pharma Res Health Sci. 2017; 5 (6): 1904-08 are evident as additives from Hispanic era in the medical with water and applied on the field as anti-microbial, anti-inflammatory, anti-cancerous forehead 3 Abdominal gas and pain Fresh leaf decoction is taken agents etc. Therefore from the above evidences the leaves of orally these species may be used as therapeutic agents after a wide 4 Fever / Toothache Fresh leaves are boiled in two clinical analysis and clinical trials. glasses of water and boiled for 15 Table 1: Sanskrit synonyms of genus Vitex21 minutes. Name Sankrit synonyms Medicinal meanings Decoction is divided into 3 parts Nirgundi Nirgudati shareeramProtects body from and taken thrice a day in a gap of rakshati rogbhyaha diseases 4 h Sindhuvara Sindu shotham vaarayati itHelps in relieving from 5 Asthma and cough Same as above sinduvaraha inflammation 6 Ulcers, Boils, Wounds Fresh leaves are used to make decoction wash the affected area with the decoction. Table 2: Morphological characteristicsof Genus Vitex leaves26 Characters Botanical characteristics Table 7: Medicinal value of Vitex negundo26 Colour Green S.No Medicinal Preparation Medicinal Value Taste Bitter 1 Kushta Skin diseases, eczema, ring worm Odor Aromnatic 2 Pleeha Spleen disorder Size Compound 3 Gulma Abdominal tumor Shape Trifoliate (Occasionally pentafoliate) 4 Deepani Carminative Surface Above-Globrous; Below-Tomentose 5 Keshya Hair quality improvement