Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change)

Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, E. histolytica Stain specimen = stool, bile results should be sent as E. histolytica DNA fluid, duodenal fluid, 260373001^DETECTED^SCT with E. histolytica Antigen Amebiasis (Entamoeba histolytica) No No tissue large intestine, disease/organism-specific DNA LOINC E. histolytica Antibody tissue small intestine codes OR a generic CIDT-LOINC code E. histolytica IgM with organism-specific DNA SNOMED E. histolytica IgG codes E. histolytica Total Antibody Ova and Parasite Anthrax Antibody Anthrax Antigen Anthrax EITB Acute Anthrax EITB Convalescent Anthrax Yes No Culture ELISA PCR Stain/microscopy Stain/spore ID

Eastern Equine Encephalitis Antibody Eastern Equine Encephalitis virus IgG Antibody Eastern Equine Encephalitis virus IgM Arboviral neuroinvasive and non- Eastern Equine Encephalitis virus RNA neuroinvasive disease: Eastern equine California serogroup virus Antibody encephalitis virus disease; LaCrosse Equivocal results are accepted for all California serogroup virus IgG Antibody virus disease (other California arborviral diseases; California serogroup virus IgM Antibody specimen = blood, serum, serogroup virus disease), Powassan Zika IgM results can include the California serogroup virus RNA No No cerebrospinal fluid; urine virus disease, St. Louis encephalitis following results: presumptive Zika LaCrosse virus Antibody is specific to Zika RNA virus disease, West Nile virus infection, positive, presumptive other Flavivirus, LaCrosse virus IgG Antibody Western equine encephalitis virus Negative, and possible Zika positive LaCrosse virus IgM Antibody disease, infection, Other LaCrosse virus RNA Powassan virus Antibody arthropod-borne disease Powassan virus IgG Antibody Powassan virus IgM Antibody Powassan virus RNA St. Louis Encephalitis virus Antibody St. Louis Encephalitis virus IgG Antibody St. Louis Encephalitis virus IgM Antibody St. Louis Encephalitis virus RNA West Nile virus Antibody

Last updated 07/31/2018 1 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change)

West Nile virus IgG Antibody

West Nile virus IgM Antibody

Arboviral neuroinvasive and non-

neuroinvasive disease: Eastern equine West Nile virus RNA encephalitis virus disease; LaCrosse Equivocal results are accepted for all virus disease (other California arborviral diseases; specimen = blood, serum, Western Equine Encephalitis virus Antibody serogroup virus disease), Powassan Zika IgM results can include the No No cerebrospinal fluid; urine Western Equine Encephalitis virus IgG virus disease, St. Louis encephalitis following results: presumptive Zika is specific to Zika RNA Antibody virus disease, West Nile virus infection, positive, presumptive other Flavivirus, Western Equine Encephalitis virus IgM Western equine encephalitis virus Negative, and possible Zika positive Antibody disease, Zika virus infection, Other arthropod-borne disease Western Equine Encephalitis virus RNA Zika virus IgM Antibody

Zika virus RNA Blood smear Babesia divergens IFA IgG-titer Babesia mircroti IFA IgG-titer Babesiosis (reportable as of 1/2014) No No Babesia microti IFA total Ig-titer Babesia duncani IFA IgG-titer PCR Culture C. botulinum DNA C. botulinum Antigen C. botulinum Antibody C. botulinum IgM Botulism (foodborne, infant, and C. botulinum IgG Yes No wound) C. botulinum Total Antibody C. botulinum Toxin C. botulinum Toxin A C. botulinum Toxin B C. botulinum Toxin E C. botulinum Toxin F Brucella Antibody Brucella DNA Brucella IgA Antibody Negative results are accepted for No No specimen = blood, serum Brucella IgG Antibody Brucella IgG/IgM Antibody Brucella IgM Antibody Culture agglutination test

Last updated 07/31/2018 2 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Culture Culture independent diagnostic tests' Campylobacter Stain (CIDT), like BioFire panel or BD MAX, Campylobacter DNA results should be sent as Campylobacter Antigen 260373001^DETECTED^SCT with No No Campylobacter Antibody disease/organism-specific DNA LOINC Campylobacter IgM codes OR a generic CIDT-LOINC code Campylobacter IgG with organism-specific DNA SNOMED Campylobacter Total Antibody codes Campylobacter PCR

Carbapenemase-producing cabapenem- Carba NP resistant (CP-CRE) Carbapenem Inactivation Method (CIM) (CP-CRE Enterobacter spp, CP-CRE Results should include the organism , CP-CRE spp, No Yes detected as well as the gene resistance Culture CP-CRE Other); mechanism or phenotype test result (see second sheet for list of most Metallo-β-lacatamase testing (MBL) common organisms identified) Modified Carbapenem Inactivation Method (mCIM) Culture DFA (Direct Flourescent antibody) EIA (Enzyme Immunoassay) NAAT (Nucleic Amplification Test), unspecified Specimen type should be specific (e.g. NAAT, LCR (Ligase Chain Reaction) No No vaginal, cervical, urethral, etc.) and not NAAT, NASBA (Nucleic Acid Sequence Based generic (e.g. genital, swab, etc.) Analysis) NAAT, PCR (Polymerase Chain Reaction) NAAT, SDA (Strand Displacement NAAT, TMA (Transcription Mediated Amplification)

Culture (organism = trachomatis) DFA (Direct Flourescent antibody) EIA (Enzyme Immunoassay)

NAAT (Nucleic Amplification Test), unspecified Specimen type should be specific (e.g. Chlamydia infections No No vaginal, cervical, urethral, etc.) and not NAAT, LCR (Ligase Chain Reaction) generic (e.g. genital, swab, etc.) NAAT, NASBA (Nucleic Acid Sequence Based Analysis) NAAT, PCR (Polymerase Chain Reaction) NAAT, SDA (Strand Displacement Amplification) NAAT, TMA (Transcription Mediated Amplification)

Last updated 07/31/2018 3 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Culture (organism = ) V. cholerae Stain Culture independent diagnostic tests' V. cholerae DNA (CIDT), like BioFire panel or BD MAX, V. cholerae Antigen

results should be sent as V. cholerae O1 Antigen 260373001^DETECTED^SCT with V. cholerae O139 Antigen Yes No disease/organism-specific DNA LOINC V. cholerae Antibody codes OR a generic CIDT-LOINC code V. cholerae O1 Antibody with organism-specific DNA SNOMED V. cholerae O139 Antibody codes V. cholerae Toxin V. cholerae DNA by PCR V. cholerae Toyin gene by PCR Culture Coccidioides Stain Coccidioides DNA Coccidioides Antigen Coccidioidomycosis No No Coccidioides Antibody Coccidioides IgM Coccidioides IgG Coccidioides Total Antibody Prion Protein Creutzfeldt-Jakob Disease No No CJD 14-3-3 Protein Tau Protein

Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, Cryptosporidium Stain specimen = stool, results should be sent as Cryptosporidium DNA duodenal fluid, tissue 260373001^DETECTED^SCT with Cryptosporidium Antigen Cryptosporidiosis No No large intestine, tissue disease/organism-specific DNA LOINC Cryptosporidium Antibody small intestine codes OR a generic CIDT-LOINC code Cryptosporidium IgM with organism-specific DNA SNOMED Cryptosporidium IgG codes Cryptosporidium Total Antibody Ova and Parasite

Culture independent diagnostic tests' Cyclospora Stain (CIDT), like BioFire panel or BD MAX, specimen = stool, results should be sent as Cyclosporiasis (organism = Cyclospora duodenal fluid, tissue 260373001^DETECTED^SCT with Cyclospora DNA No No cayetanensis) large intestine, tissue disease/organism-specific DNA LOINC small intestine codes OR a generic CIDT-LOINC code Cyclospora Antigen with organism-specific DNA SNOMED codes Ova and Parasite

Last updated 07/31/2018 4 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Dengue virus Antibody

Dengue virus Antigen specimen = blood, serum, Dengue No No Equivocal results are accepted cerebrospinal fluid Dengue virus IgG Antibody

Dengue virus IgM Antibody Dengue virus RNA

Culture (organism = Corynebacterium

diphtheriae)

Diphtheria Yes No Diphtheria IgM Antibody

Diphtheria Toxin Culture independent diagnostic tests' Culture (CIDT), like BioFire panel or BD MAX, E. coli DNA results should be sent as E. coli O157:H7 and other E. coli Antigen 260373001^DETECTED^SCT with enterohemorrhagic (Shiga-toxin No No specimen = stool E. coli O157:H7 Antigen disease/organism-specific DNA LOINC producing) E. coli E. coli O157 Antigen codes OR a generic CIDT-LOINC code E. coli Shiga Toxin with organism-specific DNA SNOMED E. coli Shiga Toxin 1 codes E. coli Shiga Toxin 2

Anaplasma phagocytophila Antibody Anaplasma phagocytophila IgG Antibody Anaplasma phagocytophila IgM Antibody Culture DNA/PCR Ab Ehrlichia chaffeensis IgG Ab Ehrlichia chaffeensis IgM Ab Ehrlichia equi Antibody Ehrlichia equi IgG Antibody specimen = blood, serum, / No No Ehrlichia equi IgM Antibody cerebrospinal fluid Ehrlichia phagocytophila Antibody Ehrlichia phagocytophila DNA Ehrlichia phagocytophila IgG Antibody Ehrlichia phagocytophila IgM Antibody HGE Antibody HGE IgG Antibody HGE IgM Antibody HME IgG Antibody HME IgM Antibody Immunostain Morulae visualization

Last updated 07/31/2018 5 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change)

Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, Giardia Stain specimen = stool, bile results should be sent as Giardia DNA fluid, duodenal fluid, 260373001^DETECTED^SCT with Giardia Antigen Giardiasis No No tissue large intestine, disease/organism-specific DNA LOINC Giardia Antibody tissue small intestine codes OR a generic CIDT-LOINC code Giardia IgM with organism-specific DNA SNOMED Giardia IgG codes Giardia Total Antibody Ova and Parasite

Culture (Organism = Neisseria gonorrheoae) DFA (Direct Flourescent antibody) EIA (Enzyme Immunoassay) NAAT (Nucleic Amplification Test), unspecified Specimen type should be specific (e.g. NAAT, LCR (Ligase Chain Reaction) Gonococcal infections No Yes vaginal, cervical, urethral, etc.) and not NAAT, NASBA (Nucleic Acid Sequence Based generic (e.g. genital, swab, etc.) Analysis) NAAT, PCR (Polymerase Chain Reaction) NAAT, SDA (Strand Displacement NAAT, TMA (Transcription Mediated Amplification) Gram stain (Smear) Culture independent diagnostic tests' specimen = blood, serum, (CIDT), like BioFire panel or BD MAX, Culture (organism = influenzae) plasma, cerebrospinal results should be sent as (invasive fluid, pericardial fluid, 260373001^DETECTED^SCT with H. influenzae Stain No No disease) pleural fluid, synovial disease/organism-specific DNA LOINC fluid, peritoneal fluid, codes OR a generic CIDT-LOINC code H. influenzae DNA bone, etc with organism-specific DNA SNOMED codes H. influenzae Antigen Hantavirus Antibody Negative results are accepted for Hantavirus IgG Antibody Hantavirus No No Hantavirus IgG/IgM Antibody Hantavirus IgM Antibody Hantavirus RNA Hep A RNA Hepatitis A No No Hep A IgM Anti-Hbe Anti-HBs HBeAg No No HBsAg HBV DNA IgM anti-HBc

Last updated 07/31/2018 6 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) anti-HCV Hepatitis C No No HCV RNA RIBA Hep D Virus IgG Hep D Virus Antibody Hepatitis D (delta hepatitis) No No Hep D Virus RNA Hep D Virus IGM Antibody Hep E RNA Hep E IgM Hepatitis E No No Hep E IgG Hep E Total Antibody CD4 Count CD4 Percent HIV-1 IA/EIA (Enzyme Immunoassay) HIV-1/2 IA/EIA (Enzyme Immunoassay) HIV-1/2 Antigen/Antibody (Antigen/Antibody) HIV-1 WB (Western Blot) HIV-1 IFA (Indirect Fluorescent Antibody) HIV-2 IA/EIA (Enzyme Immunoassay) HIV-2 WB (Western Blot) ALL CD4 results and ALL HIV viral loads HIV-1/2 type differentiating (e.g. Multispot) (including <20 DETECTED AND <20 NOT HIV-1 Ab DETECTED) are reportable; HIV-2 Ab separate questionnaire will be HIV-1 RNA/DNA NAAT (Qualitative Viral Load) distributed to collect additional (NAAT=Nucleic Acid Amplification Test) HIV nucleotide information on tests performed in- HIV-1 p24 Antigen sequencing results house; newborn infant or child born to HIV No HIV-1 Culture are accepted but an HIV infected mother is reportable as not required perinatal exposure to HIV and any HIV-2 RNA/DNA NAAT (Qualitative Viral Load) subsequent test results on every such (NAAT=Nucleic Acid Amplification Test) exposed newborn infant or child until HIV-2 Culture such time that either an HIV infection or a seroreversion status that is negative is HIV-1 RNA/DNA NAAT (Quantitative Viral confirmed; Load) (NAAT=Nucleic Acid Amplification Test)

HIV-2 RNA/DNA NAAT (Quantitative Viral Load) (NAAT=Nucleic Acid Amplification Test) Rapid – Chembio Rapid – Clearview Rapid – Determine Rapid – Insti Rapid – Oraquick Rapid – Unigold Rapid – Other

Last updated 07/31/2018 7 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Commercial Rapid Diagnostic Test

Direct fluorescent antibody (DFA)

Enzyme immunoassay (EIA) Immunohistochemistry (IHC)

Must be filtered for hosptialized Indirect fluorescent antibody (IFA) inpatients ONLY; Date of hospital Influenza A (2009 pandemic A) RT-PCR admission must be reported manually in Influenza A (2009 pandemic H1) RT-PCR ODRS; Influenza A (H1) RT-PCR Culture independent diagnostic tests' Influenza A (H3) RT-PCR (CIDT), like BioFire panel or BD MAX, Influenza associated-hospitalization No No Influenza A (H5) RT-PCR results should be sent as 260373001^DETECTED^SCT with Influenza A (H&) RT-PCR disease/organism-specific DNA LOINC Influenza A RT-PCR codes OR a generic CIDT-LOINC code Influenza A-Fluorescent Antibody with organism-specific DNA SNOMED Influenza B RT-PCR codes Influenza B-Fluorescent Antibody Rapid molecular RT-PCR Viral Culture Virus ID-HI Commercial Rapid Diagnostic Test Direct fluorescent antibody (DFA) Enzyme immunoassay (EIA) Immunohistochemistry (IHC) Indirect fluorescent antibody (IFA) Influenza A (2009 pandemic A) RT-PCR Influenza A (2009 pandemic H1) RT-PCR Influenza A (H1) RT-PCR Influenza A (H3) RT-PCR Influenza A Novel Virus and Influenza- Yes No Difficult to report these via ELR Influenza A (H5) RT-PCR associated pediatric mortality Influenza A (H&) RT-PCR Influenza A RT-PCR Influenza A-Fluorescent Antibody Influenza B RT-PCR Influenza B-Fluorescent Antibody Rapid molecular RT-PCR Viral Culture

Virus ID-HI

Last updated 07/31/2018 8 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Culture Legionella DFA Legionella DNA Legionella Antigen

L. pneumophila Antigen Legionella Antibody Legionella IgM Legionellosis - Legionnaires' Disease No No Legionella IgG Legionella Total Antibody L. pneumophila Antibody L. bozemaniae Antibody L. dumoffii Antibody L. gormanii Antibody L. longbeachae Antibody L. micdadei Antibody Culture Leprosy (Hansen disease) No No Leprosy Stain Leprosy DNA Leptospira Antibody Leptospira antigen Negative results are accepted for Leptospirosis No No Leptospira DNA Leptospira IgG/IgM Antibody Leptospira IgG Antibody Leptospira IgM Antibody

Culture (organism = Listeria monocytogenes)

Listeria DNA

Culture independent diagnostic tests' specimen = blood, serum, Listeria Antigen (CIDT), like BioFire panel or BD MAX, plasma, cerebrospinal results should be sent as fluid, pericardial fluid, 260373001^DETECTED^SCT with Listeria Antibody Listeriosis No No pleural fluid, synovial disease/organism-specific DNA LOINC fluid, peritoneal fluid, codes OR a generic CIDT-LOINC code bone, placenta (in a Listeria IgM with organism-specific DNA SNOMED pregnant woman), etc codes Listeria IgG

Listeria Total Antibody

Listeria Whole Genome Sequencing

Last updated 07/31/2018 9 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change)

Borrelia burgdorferi Antibody Borrelia burgdorferi IgA Antibody Borrelia burgdorferi IgG & IgM Antibody

Borrelia burgdorferi IgG Antibody Borrelia burgdorferi IgG Antibody Western specimen = blood, serum, blot Lyme Disease No No cerebrospinal fluid Borrelia burgdorferi IgM Antibody Borrelia burgdorferi IgM Antibody Western blot PCR Borrelia burgdorferi EIA Borrelia burgdorferi IFA Culture Smear Malaria No No specimen = blood, serum Plasmodium DNA Plasmodium Antigen Culture Measles IgG & IgM Antibody Measles yes Measles IgM Antibody PCR Culture independent diagnostic tests' Culture (CIDT), like BioFire panel or BD MAX, Virus DNA/RNA results should be sent as Meningitis - aseptic/viral Virus Antigen specimen = cerebrospinal 260373001^DETECTED^SCT with (see third sheet for list of most No No fluid disease/organism-specific DNA LOINC Virus Antibody common organisms identified) codes OR a generic CIDT-LOINC code Virus IgM with organism-specific DNA SNOMED Virus IgG codes Virus Total Antibody Culture Stain Bacteria DNA Bacteria Antigen Meningitis - bacterial (Not N. specimen = blood, serum, Bacteria Antibody meningitidis) No No cerebrospinal fluid; only Bacteria IgM (see fourth sheet for list of most for meningitis patients common organisms identified) Bacteria IgG

Bacteria Total Antibody

Last updated 07/31/2018 10 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change)

Culture independent diagnostic tests'

specimen = blood, serum, (CIDT), like BioFire panel or BD MAX, plasma, cerebrospinal results should be sent as Culture (organism = ) - Neisseria fluid, pericardial fluid, 260373001^DETECTED^SCT with N. meningitidis Stain Yes No meningitidis pleural fluid, synovial disease/organism-specific DNA LOINC N. meningitidis DNA fluid, peritoneal fluid, codes OR a generic CIDT-LOINC code N. meningitidis Antigen bone, etc with organism-specific DNA SNOMED N. meningitidis A Antigen codes N. meningitidis B Antigen N. meningitidis C Antigen N. meningitidis Y Antigen N. meningitidis W Antigen Culture Mumps IgG & IgM Antibody Mumps No No Mumps IgM Antibody PCR

Culture (organism = ) Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, Pertussis DFA results should be sent as 260373001^DETECTED^SCT with Pertussis No No Pertussis DNA (PCR) disease/organism-specific DNA LOINC codes OR a generic CIDT-LOINC code Pertussis IgA Antibody with organism-specific DNA SNOMED codes Pertussis IgG & IgM Antibody Pertussis IgM Antibody Culture Antibody Yes No Yersinia pestis antigen Yersinia pestis DNA Culture Polio Virus 1 Antibody Polio Virus 1 Antibody Acute Polio Virus 1 Antibody Convalescent Poliomyelitis, including vaccine- Polio Virus 2 Antibody No No associated cases Polio Virus 2 Antibody Acute Polio Virus 2 Antibody Convalescent Polio Virus 3 Antibody Polio Virus 3 Antibody Acute Polio Virus 3 Antibody Convalescent

Last updated 07/31/2018 11 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) C. psittaci Antibody C. psittaci DNA Negative results are accepted for C. Psittacosis No No C. psittaci IgA Antibody psittaci IgG/IgM Antibody C. psittaci IgG Antibody

C. psittaci IgM Antibody Culture Immunostain PCR Q-Fever Antibody Q-Fever antigen Q-Fever DNA Q-Fever IgG Antibody Negative results are accepted for ALL Q- Q-Fever IgM Antibody No No Fever IgG/IgM Antibody Q-Fever Phase I Antibody Q-Fever Phase I IgA Antibody Q-Fever Phase I IgG Antibody Q-Fever Phase I IgM Antibody Q-Fever Phase II Antibody Q-Fever Phase II IgA Antibody Q-Fever Phase II IgG Antibody Q-Fever Phase II IgM Antibody Culture Microscopy Rabies - human Yes No Rabies virus Antibody Rabies virus antigen Rabies virus DNA Culture Immunostain PCR rickettsii Antibody IgG Antibody Rickettsia rickettsii IgM Antibody Rocky Mountain (RMSF) -- IgG Ab becoming Spotted Fever in No No Rickettsia parkeri IgM Ab January 2014 Rickettsia species 364D IgG Ab Rickettsia species 364D IgM Ab Rickettsia aeschlimannii IgG Ab Rickettsia aeschlimannii IgM Ab IgG Ab Rickettsia africae IgM Ab IgG Ab

Last updated 07/31/2018 12 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Rickettsia australis IgM Ab

Rickettsia conorii IgG Ab IgM Ab

Rickettsia heilongjiangensis IgG Ab

Rickettsia heilongjiangensis IgM Ab Rickettsia Helvetica IgG Ab Rickettsia Helvetica IgM Ab IgG Ab Rickettsia honei IgM Ab IgG Ab Rocky Mountain spotted fever (RMSF) -- Rickettsia japonica IgM Ab becoming Spotted Fever Rickettsiosis in No No Rickettsia marmionii subspecies IgG Ab January 2014 Rickettsia marmionii subspecies IgM Ab IgG Ab Rickettsia massiliae IgM Ab IgG Ab Rickettsia sibirica IgM Ab

Rickettsia sibirica mongolotimonae IgG Ab

Rickettsia sibirica mongolotimonae IgM Ab

Rickettsia slovaca IgG Ab

Rickettsia slovaca IgM Ab Culture Yes (not congenital PCR Rubella (congenital and not congenital) No ONLY) Rubella IgG & IgM Antibody Rubella IgM Antibody Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, Culture results should be sent as 260373001^DETECTED^SCT with No No disease/organism-specific DNA LOINC Salmonella DNA codes OR a generic CIDT-LOINC code with organism-specific DNA SNOMED codes Salmonella Antigen

Last updated 07/31/2018 13 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) PCR

Severe Acute Respiratory Syndrome SARS Antibody Yes No (SARS) SARS RNA SARS-CoV Culture

Culture independent diagnostic tests' Culture (CIDT), like BioFire panel or BD MAX, Shigella DNA results should be sent as Shigella Antigen 260373001^DETECTED^SCT with Shigella Antibody No No disease/organism-specific DNA LOINC Shigella IgM codes OR a generic CIDT-LOINC code Shigella IgG with organism-specific DNA SNOMED Shigella Total Antibody codes Shigella Shiga Toxin Culture Smallpox Yes No Electron Microscopy PCR

Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, Culture Staphylococcal aureus - resistant to results should be sent as S. aureus DNA vancomycin (VRSA) or Staphylococcal 260373001^DETECTED^SCT with No Yes S. aureus Antigen aureus - intermediate resistance to disease/organism-specific DNA LOINC S. aureus Antibody vancomycin (VRSA) codes OR a generic CIDT-LOINC code S. aureus IgM with organism-specific DNA SNOMED S. aureus IgG codes S. aureus Total Antibody Culture independent diagnostic tests' specimen = blood, serum, (CIDT), like BioFire panel or BD MAX, plasma, cerebrospinal results should be sent as Culture (organism = Streptococcus pyogenes fluid, pericardial fluid, 260373001^DETECTED^SCT with or Group A Streptococcus) Streptococcal - Group A -invasive No No pleural fluid, synovial disease/organism-specific DNA LOINC fluid, peritoneal fluid, codes OR a generic CIDT-LOINC code bone with organism-specific DNA SNOMED codes Group A Strep DNA age <= 3 months or 90 days; Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, Culture results should be sent as Streptococcal - Group B - in newborn No No 260373001^DETECTED^SCT with disease/organism-specific DNA LOINC Group B Strep DNA codes OR a generic CIDT-LOINC code with organism-specific DNA SNOMED codes Group B Strep Antigen

Last updated 07/31/2018 14 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) specimen = blood, serum, plasma, cerebrospinal Streptococcus pneumoniae - invasive fluid, pericardial fluid, No Yes disease pleural fluid, synovial Culture (organism = Streptococcus

fluid, peritoneal fluid, pneumoniae) bone S. pneumoniae DNA CIA (Chemiluminescence Immunoassay) Darkfield Microscopy EIA (Enzyme Immunoassay) FTA (Fluorescent Treponemal Antibody) Reverse sequence testing requires IgG reporting of screening, RPR and RPR IgG & IgM titer, and confirmatory FTA OR TPPA if IgM discordant results are observed MHA-TP (Microhemagglutination assay) No No between screening and RPR tests; Rapid Test separate questionnaire will be RPR (Rapid Plasma Reagin) distributed to collect additional Syphilis Health Check information on tests performed in- TPHA ( hemagglutination house assay) TPPA (Treponema pallidum particle agglutination assay)

VDRL (Venereal Disease Research Laboratory) Culture (organism=Clostridium tetani) Tetanus Antibody Tetanus Antibody Acute Tetanus Antibody Convalescent Tetanus No No Tetanus IgG & IgM Antibody Tetanus IgM Antibody Tetanus toxin Antibody Tetanus toxoid IgE Antibody

Toxic shock syndrome (TSS) (this is No No primarily a clinical diagnosis) TSS Toxin 1

Trichinella Antibody

Trichinella IgA Antibody Trichinosis No No Trichinella IgG Antibody

Trichinella IgM Antibody

Last updated 07/31/2018 15 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change)

organism = Mycobacterium tuberculosis

complex, Mycobacterium tuberculosis, Culture

Mycobacterium africanum, Tuberculosis, including multi-drug No Yes Mycobacterium bovis, Mycobacterium resistant (MDR-TB) bovis BCG, Mycobacterium microti, Nucleic acid amplification Mycobacterium canettii, M. caprae, M. pinnipedii, and M. mungi

Smear

F. tularensis Antibody F. tularensis DNA specimen = blood, serum, Negative results are accepted for F. tularensis IgA Antibody Yes No cerebrospinal fluid Tularemia IgG/IgM Antibody F. tularensis IgG Antibody F. tularensis IgM Antibody Culture Tularemia PCR Culture (Salmonella Typhi) No No S. Typhi DNA S. Typhi Antigen culture VZV DNA Varicella No No VZV IgG Antibody Convalescent Direct fluorescent antibody (DFA)

Culture independent diagnostic tests' (CIDT), like BioFire panel or BD MAX, results should be sent as 260373001^DETECTED^SCT with Culture Vibriosis No No disease/organism-specific DNA LOINC codes OR a generic CIDT-LOINC code with organism-specific DNA SNOMED codes Vibrio DNA Culture Ebola Antibody Ebola Antigen Ebola IgG Antibody Viral Hemorrhagic Fever (VHF) Yes No Ebola IgM Antibody Ebola RNA Electron Microscopy Lassa Antibody IgG

Last updated 07/31/2018 16 Ohio Department of Health, Bureau of Infectious Diseases Reporting specifics for select diseases reportable by ELR Class A, requires immediate phone Susceptibilities specimen type Reportable test name (can change if Disease Name other specifics+ call to local health required* specifics~ state/federal case definition or department reporting requirements change) Lass Antigen IgM Lassa Antigen Marburg Antibody Viral Hemorrhagic Fever (VHF) Yes No Marburg Antigen

Marburg IgG Antibody Marburg IgM Antibody PCR

Yellow fever virus Antibody specimen = blood, serum, Yellow fever Yes Equivocal results are accepted Yellow fever virus IgG Antibody cerebrospinal fluid Yellow fever virus IgM Antibody Yellow fever virus RNA Culture independent diagnostic tests' Culture (CIDT), like BioFire panel or BD MAX, Yersinia Stain results should be sent as Yersinia DNA 260373001^DETECTED^SCT with Yersinia Antigen No No disease/organism-specific DNA LOINC Yersinia Antibody codes OR a generic CIDT-LOINC code Yersinia IgM with organism-specific DNA SNOMED Yersinia IgG codes Yersinia Total Antibody

* For all diseases where susceptibility results are NOT required, ODH will still accept and process any susceptibility results sent for ALL diseases

~ All specimen types should be sent using a standardized SNOMED or HL7 code

+ All HL7 messages should include standardized LOINC codes for tests performed and SNOMED codes for test results, unless performing a test with a numeric result value

Last updated 07/31/2018 17 Most commonly reported CRE etiologies: • amalonaticus • Citrobacter braakii • Citrobacter diversus • Citrobacter europaeus • Citrobacter farmer • • Citrobacter gillenii • • Citrobacter murliniae • Citrobacter pasteurii • Citrobacter rodentium • • Citrobacter youngae • Citrobacter Werkmanii • Citrobacter aerogenes • Citrobacter agglomerans • Citrobacter amnigenus • Citrobacter arachidis • Citrobacter asburiae • Enterobacter cancerogenous • • Enterobacter cowanii • Enterobacter dissolvens • Enterobacter gergoviae • Enterobacter helveticus • Enterobacter hormaechei • Enterobacter intermedius • Enterobacter kobei • Enterobacter ludwigii • Enterobacter mori • Enterobacter nimipressuralis • Enterobacter oryzae • Enterobacter pulveris • Enterobacter pyrinus • Enterobacter radicincitans • Enterobacter sakazakii • • Enterobacter turicensis • Echerichia coli • • Klebsiella grimonti • Klebsiella michiganensis • • Klebsiella ozaenae • Most commonly reported CRE etiologies: • Klebsiella quasipneumoniae • Klebsiella rhinoscleromatis • Klebsiella variicola • Morganella morganii • Proteus hauseri • • Proteus myxofaciens • Proteus penneri • • Providencia alcalifaciens • Providencia burhodogranariea • Providencia heimbachae • • Providencia rustigianii • Providencia sneebia • • Raolultella terrigena • Raolultella electrica • Raolultella ornithinolytica • Raolultella planticola • Serratia aquatilis • Serratia entomophila • Serratia ficaria • Serratia fonticola • Serratia glossinae • Serratia grimesii • Serratia liquefaciens • • Serratia myotis • Serratia nematodiphila • Serratia odorifera • Serratia plymuthica • Serratia proteamaculans • Serratia quinivorans • Serratia rubidaea • Serratia symbiotica • Serratia ureilytica • Serratia vespertilionis Most commonly reported Aseptic/Viral Meningitis etiologies: • Adenovirus • Coxsackie A virus • Coxsackie B virus • Coxsackie virus • Cytomegalovirus • Dengue virus – reported as dengue • Echovirus • Enterovirus • Epstein-Barr virus • virus • Influenza B virus • JC Virus • LaCrosse Virus – reported as LaCrosse virus disease • Lymphocytic choriomeningitis virus • Parechovirus • Parvovirus • Picornaviridae • St. Louis Encephalitis virus – reported as SLE • Varicella Zoster virus • West Nile virus – reported as WNV Most commonly reported Bacterial Meningitis etiologies: • Abiotrophia defectiva • • Acinetobacter iwoffii • Acinetobacter sp. • Actinomyces odontolyticus • Actinomyces sp. • Alcaligenes xylosoxidans • sp. • Bacteroides fragilis • Brevundimonas vesicularis • Candida albicans • Candida parapsilosis • Capnocytophaga sp. • Citrobacter freundii • Citrobacter koseri • Citrobacter sp. • Clostridium difficile • Clostridium perfringens • Coccidioides sp. • Corynebacterium sp. • Cronobacter sakazakii • Cryptococcus neoformans • Cryptococcus sp. • Eikenella sp. • Enterobacter aerogenes • Enterobacter cloacae • Enterococcus avium • Enterococcus faecalis • Enterococcus faecium • Enterococcus raffinosus • Enterococcus sp. • Escherichia coli • Eubacterium lentum • Fusobacterium sp. • Haemophilus influenzae – reported as invasive H. flu • Haemophilus parainfluenzae • Herellea sp. • Histoplasma capsulatum • Klebsiella oxytocin • Klebsiella pneumoniae • Klebsiella sp. • Lactobacillus sp. • Listeria monocytogenes – reported as listeriosis • Micrococcus sp. • Most commonly reported Bacterial Meningitis etiologies: • Mycoplasma sp. • Neisseria lactamica • Neisseria meningitidis – reported as meningococcal disease • Neisseria sp. • Pantoea agglomerans • • Pasturella sp. • Pediococcus sp. • Peptostreptococcus anaerobius • Propionibacterium acnes • Propionibacterium sp. • Proteus mirabilis • • Pseudomonas fluorescens • Pseudomonas sp. • Ralstonia pickettii • Serratia marcescens • Serratia sp. • Sphingomonas paucimobilis • Staphylococcus aureus • Staphylococcus capitus • Staphylococcus epidermidis • Staphylococcus hominis • Staphylococcus schleiferi • Staphylococcus sp. • Staphylococcus warneri • Stenotrophomonas maltophilia • Streptococcus bovis • Streptococcus constellatus • Streptococcus intermedius • Streptococcus milleri • Streptococcus mitis • Streptococcus mutans • Streptococcus oralis • Streptococcus pneumoniae – reported as ISP • Streptococcus salivarius • Streptococcus viridans • Group A Strep. (Streptococcus pyogenes) – reported as invasive GAS • Group B Strep. (Streptococcus agalactiae) – reported as newborn GBS in infants > 3 months • Group C Strep. • Group D Strep. • Group F Strep. • Streptococcus sp.