Laval, Canada Facility At-A-Glance

FACILITY OVERVIEW Laval, Canada

The Laval, Quebec, Canada site is located near two neighboring sites in Montreal. The facility performs general toxicology and specialized studies which include, ocular, DART, radiation biology, neurotoxicology, and dermal. The facility also supports safety pharmacology programs and laboratory sciences support service.

Laboratories and Facilities -- LVP models • 86 rooms (59 multispecies rooms) -- JET • 2 surgical suites -- Seizure and sleep models • 176,000 sq. ft. (Building 445: 156K, Building 475: 20K) -- Efficacy pharmacology • Specialty services Staff -- Ocular • 575 employees, including: -- Continuous infusion -- 26 PhDs -- Stereotaxic surgery and brain delivery -- 13 DVMs -- Radiation biology -- 2 DABTs -- Wound healing and dermal toxicology -- 25 study directors -- Orthopedic implants and biologics -- 21 scientists -- Long-bone defects and fracture repair -- 5 DACVPs -- Neurotoxicology -- 6 Pathologists -- Musculoskeletal toxicology Service Areas/Study Types -- Surgery • Toxicology • Pathology -- General -- Histopathology -- Juvenile -- Clinical pathology -- Reproductive -- ICH -- Acute -- Carcinogenicty • Safety Pharmacology -- GLP ion channel studies -- CNS in vitro electrophysiology: brain slice and dorsal root ganglia -- Core battery and follow-up respiratory assessments -- Core battery and follow-up CNS assessments -- Core battery and follow-up cardiovascular assessments

EVERY STEP OF THE WAY www.criver.com Service Areas/Study Types (Continued) Quality and Process Initiatives • Laboratory sciences • Excellent inspection history -- Analytical chemistry • On-site IT support -- Bioanalysis Humane Care Initiative -- Immunology Charles River is a worldwide leader in the humane care Compliance, Certifications, Accreditations and of laboratory animals. We work hand-in-hand with the Professional Affiliations scientific community to understand how living conditions, • The Laval facility operates in compliance with the handling procedures and stress play an important role in requirements of the following regulatory agencies or the quality and efficiency of research. accredited organization: -- OECD -- FDA -- USDA -- EPA -- USNRC -- AAALAC