Supplementary Online Content

Amaro A, Parodi F, Diedrich K, et al. Analysis of the expression and single-nucleotide variant frequencies of the buyrophilin-like 2 in patients with uveal melanoma. JAMA Ophthalmol. Published online August 11, 2016. doi: 10.1001/jamaophthalmol.2016.2691.

eTable 1. M1- and M2-poloarization

eTable 2. M1- and M2-polarization genes that are associated with disease-free survival of patients with uveal melanoma

This supplementary material has been provided by the authors to give readers additional information about their work.

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 eTable 1. M1- and M2-poloarization genes 203308_x NM_000195 | HPS1 3257 Hs.40456 203308_x 10 GO:00070 - AI185798 Hermansky-Pudlak syndrome 1 chr10:100 1E+08 1E+08 -1.13131 6.095084 0.859709 0.14105 1.819564 205022_s NM_001085471 FOXN3 1112 Hs.43428 205022_s 14 GO:00000 - NM_0051 forkhead box N3 chr14:896 89622516 90085494 -0.83339 6.106332 1.983495 0.324826 3.850649 204226_a NM_001164380 STAU2 27067 Hs.56181 204226_a 8 GO:00068 - NM_0143 staufen, RNA binding , chr8:7446 74461843 74659943 -0.95841 6.106973 0.850648 0.139291 1.804766 208639_x NM_005742 | PDIA6 10130 Hs.21210 208639_x 2 GO:00064 - BC001312 protein disulfide chr2:1092 10923518 10952960 -0.37258 6.110976 1.043652 0.170783 2.061971 204295_a NA NA NA NA 204295_a NA NA NA NM_0031 NA chrNA:-1-- -1 -1 -0.94773 6.113623 0.686679 0.112319 1.613194 202609_a NM_004447 | EPS8 2059 Hs.59116 202609_a 12 GO:00071 - NM_0044 epidermal growth factor chr12:157 15773075 15942510 -1.30353 6.122138 3.44239 0.562286 10.58922 204290_s NM_005589 | ALDH6A1 4329 Hs.29397 204290_s 14 GO:00551 - NM_0055 aldehyde dehydrogenase 6 chr14:745 74526873 74551196 -0.94848 6.123863 1.719006 0.280706 3.370511 212804_s NM_015635 | GAPVD1 26130 Hs.49513 212804_s 9 GO:00071 + AI797397 GTPase activating protein and chr9:1280 1.28E+08 1.28E+08 0.130083 6.123958 0.852913 0.139275 1.799541 52940_at NA NA NA NA 52940_at NA NA NA AA08576 NA chrNA:-1-- -1 -1 2.969083 6.124078 1.110866 0.181393 2.155788 41047_at NM_024112 | C9orf16 79095 Hs.52241 41047_at 9 GO:00081 + AI885170 9 open reading chr9:1309 1.31E+08 1.31E+08 2.627325 6.128819 1.1017 0.179757 2.141424 217886_a NM_001159969 EPS15 2060 Hs.83722 217886_a 1 GO:00071 - BF213575 epidermal growth factor chr1:5181 51819934 51984995 0.766401 6.129662 0.871296 0.142144 1.838149 209083_a NM_007074 | CORO1A 11151 Hs.41506 209083_a 16 GO:00018 + U34690 coronin, actin binding protein, chr16:301 30194925 30200396 -0.31881 6.130288 1.479329 0.241315 2.808291 204487_s NM_000218 | KCNQ1 3784 Hs.95162 204487_s 11 GO:00069 + NM_0002 potassium voltage-gated chr11:246 2466220 2870339 -0.91602 6.135376 1.733615 0.282561 3.243998 218124_a NM_017750 | RETSAT 54884 Hs.44040 218124_a 2 GO:00551 - NM_0177 retinol saturase (all-trans- chr2:8556 85569078 85581821 0.798797 6.136715 1.058639 0.172509 2.091179 200652_a NM_003145 | SSR2 6746 Hs.74564 200652_a 1 GO:00066 - NM_0031 signal sequence , beta chr1:1559 1.56E+08 1.56E+08 -3.04633 6.142696 0.660982 0.107605 1.58265 212640_a NM_198402 | PTPLB 201562 Hs.70548 212640_a 3 GO:00160 - AV71260 protein - chr3:1232 1.23E+08 1.23E+08 0.109175 6.146216 2.715988 0.441896 6.180602 200926_a NM_001025 | RPS23 6228 Hs.52719 200926_a 5 GO:00064 - NM_0010 ribosomal protein S23 chr5:8156 81569140 81574235 -2.33082 6.147136 0.584687 0.095115 1.498846 211329_x NM_000410 | HFE 3077 Hs.23332 211329_x 6 GO:00024 + AF115264 hemochromatosis chr6:2608 26087508 26095469 -0.04912 6.147206 1.059956 0.172429 2.084085 204950_a NM_014959 | CARD8 22900 Hs.44614 204950_a 19 GO:00429 - NM_0149 caspase recruitment domain chr19:487 48711343 48752925 -0.84366 6.152741 1.905161 0.309644 3.846062 202185_a NM_001084 | PLOD3 8985 Hs.15335 202185_a 7 GO:00551 - NM_0010 procollagen-, 2- chr7:1008 1.01E+08 1.01E+08 -1.43903 6.156429 1.023681 0.166278 2.024901 221879_a NM_001031733 CALML4 91860 Hs.70955 221879_a 15 GO:00055 - AA88633 calmodulin-like 4 chr15:684 68483043 68498448 1.751208 6.157943 1.824663 0.29631 3.481771 214221_a NM_015120 | ALMS1 7840 Hs.18472 214221_a 2 GO:00069 + AI825212 Alstrom syndrome 1 chr2:7361 73612885 73837046 0.306488 6.158164 0.682931 0.110899 1.603871 213103_a NM_052851 | STARD13 90627 Hs.50770 213103_a 13 GO:00071 - AA12802 StAR-related lipid transfer chr13:336 33677272 33859901 0.1677 6.164741 1.521691 0.246838 2.881072 209240_a NM_181672 | OGT 8473 Hs.40541 209240_a X GO:00071 + AF070560 O-linked N-acetylglucosamine chrX:7075 70752911 70795747 -0.29981 6.169447 1.209091 0.19598 2.323459 65630_at NM_001042463 TMEM80 283232 Hs.44866 65630_at 11 GO:00160 + AI742455 transmembrane protein 80 chr11:695 695615 704127 3.554588 6.169681 1.490491 0.241583 2.859872 202316_x NM_001105562 UBE4B 10277 Hs.59397 202316_x 1 GO:00002 + AW24171 ubiquitination factor E4B (UFD2 chr1:1009 10093015 10241294 -1.3948 6.170145 1.253303 0.203124 2.369068 206492_a NM_001166243 FHIT 2272 Hs.65599 206492_a 3 GO:00062 - NM_0020 fragile histidine triad gene chr3:5973 59735037 61237133 -0.63671 6.171241 0.715333 0.115914 1.63816 201347_x NM_012203 | GRHPR 9380 Hs.15574 201347_x 9 GO:00551 + NM_0122 glyoxylate chr9:3742 37422706 37436986 -1.87051 6.174938 0.841456 0.13627 1.788451 211668_s NM_001145031 PLAU 5328 Hs.77274 211668_s 10 GO:00015 + K03226 plasminogen activator, chr10:756 75670861 75677256 -0.00818 6.187258 2.016798 0.32596 4.101064 200598_s NM_003299 | HSP90B1 7184 Hs.19237 200598_s 12 GO:00016 + AI582238 heat shock protein 90kDa beta chr12:104 1.04E+08 1.04E+08 -3.37115 6.194171 1.660065 0.268004 3.093477 202605_a NM_000181 | GUSB 2990 Hs.25523 202605_a 7 GO:00081 - NM_0001 glucuronidase, beta chr7:6542 65425674 65447301 -1.30482 6.19799 1.50091 0.242161 2.826573 202665_s NM_001077269 WIPF1 7456 Hs.12806 202665_s 2 GO:00300 - NM_0033 WAS/WASL interacting protein chr2:1754 1.75E+08 1.76E+08 -1.28676 6.206483 0.796574 0.128345 1.743269 221194_s NM_016125 | RNFT1 51136 Hs.53170 221194_s 17 GO:00160 - NM_0161 ring finger protein, chr17:580 58029723 58042117 1.434372 6.207411 1.056306 0.170169 2.067375 203332_s NM_001017915 INPP5D 3635 Hs.26288 203332_s 2 GO:00067 + NM_0055 inositol polyphosphate-5- chr2:2339 2.34E+08 2.34E+08 -1.12618 6.211592 1.264531 0.203576 2.383988 203959_s NM_001083621 ZBTB40 9923 Hs.41896 203959_s 1 GO:00454 + NM_0148 and BTB domain chr1:2277 22778343 22857650 -1.00454 6.21406 0.940932 0.15142 1.92485 222200_s NM_001143888 BSDC1 55108 Hs.35345 222200_s 1 NA - AK021440 BSD domain containing 1 chr1:3283 32830706 32860062 1.997938 6.214454 0.715455 0.115128 1.641197 214264_s NM_145231 | C14orf14 90141 Hs.12323 214264_s 14 GO:00055 - AI656610 open reading chr14:902 90263470 90421089 0.311507 6.221441 0.894347 0.143752 1.855304 208033_s NM_001164766 ZFHX3 463 Hs.59829 208033_s 16 GO:00001 - NM_0068 zinc finger 3 chr16:728 72816787 73092534 -0.44621 6.222348 1.580732 0.254041 3.044483 215440_s NM_001080425 BEX4 56271 Hs.18473 215440_s X GO:00056 + AL523320 brain expressed, X-linked 4 chrX:1024 1.02E+08 1.02E+08 0.454995 6.225579 1.103029 0.177177 2.160216 210872_x NM_001130831 GAS7 8522 Hs.46221 210872_x 17 GO:00510 - BC001152 growth arrest-specific 7 chr17:981 9813925 10101868 -0.10121 6.228061 2.069179 0.332235 4.327868 214873_a NM_001135772 LRP5L 91355 Hs.63405 214873_a 22 GO:00160 - AL137651 low density lipoprotein chr22:257 25747385 25777544 0.384872 6.228202 0.687182 0.110334 1.606742 202164_s NM_004779 | CNOT8 9337 Hs.26703 202164_s 5 GO:00063 + AF180476 CCR4-NOT transcription chr5:1542 1.54E+08 1.54E+08 -1.44737 6.228693 1.453202 0.233308 2.695546 203357_s NM_014296 | CAPN7 23473 Hs.59523 203357_s 3 GO:00065 + NM_0142 calpain 7 chr3:1524 15247732 15294422 -1.12137 6.239099 1.577948 0.252913 2.987047 221036_s NM_001145646 APH1B 83464 Hs.51170 221036_s 15 GO:00069 + NM_0313 anterior pharynx defective 1 chr15:635 63569748 63601324 1.381998 6.240169 0.727292 0.11655 1.658962 201365_a NM_002537 | OAZ2 4947 Hs.74563 201365_a 15 GO:00065 - NM_0025 ornithine decarboxylase chr15:649 64979772 64995462 -1.85679 6.24722 0.844551 0.135188 1.791604 212248_a NM_178812 | MTDH 92140 Hs.37715 212248_a 8 GO:00001 + AI886796 metadherin chr8:9865 98656406 98742487 0.06131 6.250295 1.72747 0.276382 3.253897

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 203613_s NM_002493 | NDUFB6 4712 Hs.49366 203613_s 9 GO:00061 - NM_0024 NADH dehydrogenase chr9:3255 32553522 32573182 -1.0699 6.252187 0.771374 0.123377 1.703633 202455_a NM_001015053 HDAC5 10014 Hs.43878 202455_a 17 GO:00063 - NM_0054 histone deacetylase 5 chr17:421 42154120 42201014 -1.35005 6.257979 1.852768 0.296065 3.608243 204392_a NM_003656 | CAMK1 8536 Hs.43487 204392_a 3 GO:00071 - NM_0036 calcium/calmodulin-dependent chr3:9799 9799032 9811661 -0.93179 6.258085 2.536383 0.405297 5.586291 202386_s NM_014647 | KIAA0430 9665 Hs.17352 202386_s 16 GO:00057 - NM_0190 KIAA0430 chr16:156 15688244 15737009 -1.37221 6.260295 1.422592 0.22724 2.698285 55616_at NM_033419 | PGAP3 93210 Hs.46297 55616_at 17 GO:00065 - AI703342 post-GPI attachment to chr17:378 37827375 37844310 3.046334 6.261788 0.64587 0.103145 1.564355 211105_s NM_006162 | NFATC1 4772 Hs.53407 211105_s 18 GO:00063 + U80918 nuclear factor of activated T- chr18:771 77155771 77228177 -0.07372 6.265355 1.238266 0.197637 2.369657 218041_x NM_018976 | SLC38A2 54407 Hs.22184 218041_x 12 GO:00068 - NM_0185 solute carrier family 38, chr12:467 46751971 46766645 0.787546 6.271213 1.139243 0.181662 2.188928 203058_s NM_001015880 PAPSS2 9060 Hs.52449 203058_s 10 GO:00001 + AW29995 3'-phosphoadenosine 5'- chr10:894 89419475 89507460 -1.1878 6.274894 1.568372 0.249944 2.910533 205307_s NM_003679 | KMO 8564 Hs.72006 205307_s 1 GO:00551 + NM_0036 kynurenine 3-monooxygenase chr1:2416 2.42E+08 2.42E+08 -0.79333 6.275459 1.56256 0.248995 3.013555 208702_x NM_001142276 APLP2 334 Hs.37024 208702_x 11 GO:00019 + AI525212 amyloid beta (A4) precursor- chr11:129 1.3E+08 1.3E+08 -0.36506 6.281172 1.301858 0.207264 2.470649 210740_s NM_001142593 ITPK1 3705 Hs.30812 210740_s 14 GO:00071 - AF279372 inositol 1,3,4-triphosphate 5/6 chr14:934 93406068 93582263 -0.11676 6.283591 1.060951 0.168845 2.079824 202079_s NM_001042646 TRAK1 22906 Hs.53571 202079_s 3 GO:00063 + AI633774 trafficking protein, kinesin chr3:4213 42132745 42267267 -1.47919 6.284778 1.504445 0.239379 2.822298 201279_s NM_001343 | DAB2 1601 Hs.48198 201279_s 5 GO:00009 - BC003064 disabled homolog 2, mitogen- chr5:3937 39371779 39425335 -1.92573 6.286663 2.484912 0.395267 5.799251 201427_s NM_001085486 SEPP1 6414 Hs.27577 201427_s 5 GO:00069 - NM_0054 selenoprotein P, plasma, 1 chr5:4279 42799982 42812024 -1.81192 6.290396 3.393676 0.539501 9.426296 217992_s NM_024329 | EFHD2 79180 Hs.46537 217992_s 1 GO:00160 + NM_0243 EF-hand domain family, chr1:1573 15736390 15756839 0.780677 6.292942 0.97646 0.155168 1.960314 217844_a NM_021198 | CTDSP1 58190 Hs.44446 217844_a 2 GO:00063 + NM_0211 CTD (carboxy-terminal domain, chr2:2192 2.19E+08 2.19E+08 0.760643 6.295435 1.296502 0.205943 2.441056 212778_a NM_001100913 PACS2 23241 Hs.52562 212778_a 14 GO:00069 + AL583340 phosphofurin acidic cluster chr14:105 1.06E+08 1.06E+08 0.126918 6.308238 1.307463 0.207263 2.494276 209796_s NM_014255 | CNPY2 10330 Hs.8752 209796_s 12 GO:00057 - BC001027 canopy 2 homolog () chr12:567 56704216 56710120 -0.23143 6.309389 0.852228 0.135073 1.800903 218504_a NM_016044 | FAHD2A 51011 Hs.54638 218504_a 2 GO:00081 + NM_0160 fumarylacetoacetate chr2:9606 96068447 96078878 0.853026 6.31004 0.915895 0.145149 1.883037 201938_a NM_004642 | CDK2AP1 8099 Hs.43320 201938_a 12 GO:00000 - NM_0046 -dependent kinase 2 chr12:123 1.24E+08 1.24E+08 -1.53474 6.311707 1.137495 0.18022 2.184017 201851_a NM_003025 | SH3GL1 6455 Hs.97616 201851_a 19 GO:00071 - NM_0030 SH3-domain GRB2-like 1 chr19:436 4360367 4400471 -1.57375 6.313003 0.828933 0.131306 1.773379 203006_a NM_005539 | INPP5A 3632 Hs.52336 203006_a 10 GO:00071 + NM_0055 inositol polyphosphate-5- chr10:134 1.34E+08 1.35E+08 -1.20012 6.324002 1.716765 0.271468 3.225482 210895_s NM_006889 | CD86 942 Hs.17118 210895_s 3 GO:00069 + L25259 CD86 molecule chr3:1217 1.22E+08 1.22E+08 -0.09853 6.329838 0.805791 0.1273 1.753621 217726_a NM_016057 | COPZ1 22818 Hs.50565 217726_a 12 GO:00161 + NM_0160 protein complex, chr12:547 54718910 54745633 0.744875 6.342991 1.305939 0.205887 2.449721 209630_s NM_012164 | FBXW2 26190 Hs.49498 209630_s 9 GO:00199 - AL043967 F-box and WD repeat domain chr9:1235 1.24E+08 1.24E+08 -0.25215 6.34375 1.775477 0.279878 3.346844 218831_s NM_001136019 FCGRT 2217 Hs.11190 218831_s 19 GO:00069 + NM_0041 Fc fragment of IgG, receptor, chr19:500 50015535 50029685 0.904125 6.348593 1.667795 0.262703 3.175981 208717_a NM_005015 | OXA1L 5018 Hs.15113 208717_a 14 GO:00551 + BC001669 oxidase ( c) chr14:232 23235730 23240998 -0.36301 6.354119 1.123083 0.176749 2.172757 221787_a NM_001029863 C6orf120 387263 Hs.59137 221787_a 6 GO:00055 + BF431618 chromosome 6 open reading chr6:1701 1.7E+08 1.7E+08 1.696243 6.354336 0.75657 0.119064 1.686008 65884_at NM_016219 | MAN1B1 11253 Hs.27988 65884_at 9 GO:00081 + AA63125 mannosidase, alpha, class 1B, chr9:1399 1.4E+08 1.4E+08 3.587147 6.35865 1.037627 0.163184 2.053944 210017_a NM_006785 | MALT1 10892 Hs.60121 210017_a 18 GO:00199 + AF070528 mucosa associated lymphoid chr18:563 56338617 56417370 -0.20467 6.358783 0.951322 0.149608 1.934486 221476_s NM_002948 | RPL15 6138 Hs.38121 221476_s 3 GO:00064 + AF279903 ribosomal protein L15 chr3:2395 23958638 23962330 1.54377 6.366307 1.300011 0.204202 2.434281 212160_a NM_007235 | XPOT 11260 Hs.85951 212160_a 12 GO:00064 + AI984005 exportin, tRNA (nuclear export chr12:647 64798232 64842461 0.050444 6.366716 1.781793 0.279861 3.355617 37012_at NM_004930 | CAPZB 832 Hs.43276 37012_at 1 GO:00300 - U03271 capping protein (actin filament) chr1:1966 19665266 19812066 2.387112 6.371243 0.863284 0.135497 1.814507 200978_a NM_005917 | MDH1 4190 Hs.52652 200978_a 2 GO:00060 + NM_0059 1, NAD chr2:6381 63816121 63834328 -2.25061 6.371682 1.222711 0.191898 2.318013 201801_s NM_001078174 SLC29A1 2030 Hs.25450 201801_s 6 GO:00061 + AF079117 solute carrier family 29 chr6:4418 44187241 44201888 -1.59796 6.373187 1.952462 0.306356 3.886065 208656_s NM_006835 | CCNI 10983 Hs.51882 208656_s 4 GO:00072 - AF135162 cyclin I chr4:7796 77969178 77997125 -0.37043 6.376648 0.970983 0.152272 1.955882 213142_x NM_017439 | PION 54103 Hs.18664 213142_x 7 NA - AV70041 pigeon homolog (Drosophila) chr7:7694 76940069 77045717 0.17253 6.377883 1.897069 0.297445 3.798857 209932_s NM_001025248 DUT 1854 Hs.52798 209932_s 15 GO:00062 + U90223 deoxyuridine triphosphatase chr15:486 48623620 48635568 -0.21496 6.37794 1.254431 0.196683 2.410144 218684_a NM_001134479 LRRC8D 55144 Hs.48208 218684_a 1 GO:00160 + NM_0181 leucine rich repeat containing 8 chr1:9028 90286572 90401987 0.880744 6.381876 1.453564 0.227764 2.778378 209685_s NM_002738 | PRKCB 5579 Hs.46035 209685_s 16 GO:00064 + M13975 C, beta chr16:238 23847299 24231930 -0.24563 6.382924 1.642071 0.25726 3.134382 203778_a NM_005908 | MANBA 4126 Hs.48041 203778_a 4 GO:00081 - NM_0059 mannosidase, beta A, lysosomal chr4:1035 1.04E+08 1.04E+08 -1.03695 6.386747 0.964722 0.151051 1.9533 201378_s NM_001127320 UBAP2L 9898 Hs.49055 201378_s 1 GO:00055 + NM_0148 associated protein 2- chr1:1541 1.54E+08 1.54E+08 -1.84714 6.38991 0.921055 0.144142 1.890482 219191_s NM_016293 | BIN2 51411 Hs.14770 219191_s 12 GO:00057 - NM_0162 bridging integrator 2 chr12:516 51674822 51717938 0.962181 6.390308 1.249187 0.195481 2.354205 205645_a NM_001080975 REPS2 9185 Hs.18681 205645_a X GO:00064 + NM_0047 RALBP1 associated Eps domain chrX:1696 16964813 17171403 -0.74763 6.394962 1.111089 0.173744 2.163049 208877_a NM_002577 | PAK2 5062 Hs.51853 208877_a 3 GO:00069 + W74494 p21 protein (Cdc42/Rac)- chr3:1964 1.96E+08 1.97E+08 -0.34418 6.396842 1.256257 0.196387 2.370666 202090_s NM_006830 | UQCR11 10975 Hs.8372 202090_s 19 GO:00061 - NM_0068 ubiquinol- chr19:159 1597153 1605483 -1.4751 6.399011 0.723115 0.113004 1.65067

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 203297_s NM_004973 | JARID2 3720 Hs.63018 203297_s 6 GO:00001 + BG029530 jumonji, AT rich interactive chr6:1524 15246526 15522252 -1.1336 6.399462 1.149344 0.1796 2.205571 201518_a NM_001127228 CBX1 10951 Hs.77254 201518_a 17 GO:00063 - NM_0068 chromobox homolog 1 (HP1 chr17:461 46147414 46178883 -1.75056 6.406023 1.707969 0.266619 3.207674 218857_s NM_001083926 ASRGL1 80150 Hs.53532 218857_s 11 GO:00333 + NM_0250 asparaginase like 1 chr11:621 62104773 62160885 0.908309 6.412299 1.581449 0.246627 3.006953 210555_s NM_004555 | NFATC3 4775 Hs.63220 210555_s 16 GO:00069 + U85430 nuclear factor of activated T- chr16:681 68119374 68226113 -0.13941 6.414066 2.095566 0.326714 4.240341 202704_a NM_005749 | TOB1 10140 Hs.53155 202704_a 17 GO:00071 - AA67589 transducer of ERBB2, 1 chr17:489 48939588 48941413 -1.27648 6.414285 2.267489 0.353506 4.658703 217317_s NA NA NA NA 217317_s NA NA NA AB002391 NA chrNA:-1-- -1 -1 0.689758 6.42788 0.649567 0.101055 1.569459 211927_x NA NA NA NA 211927_x NA NA NA BE963164 NA chrNA:-1-- -1 -1 0.021265 6.444522 0.756079 0.117321 1.688137 211138_s NM_003679 | KMO 8564 Hs.72006 211138_s 1 GO:00551 + BC005297 kynurenine 3-monooxygenase chr1:2416 2.42E+08 2.42E+08 -0.06999 6.445388 2.355968 0.365528 5.227941 212600_s NM_003366 | UQCRC2 7385 Hs.52880 212600_s 16 GO:00061 + AV72738 ubiquinol-cytochrome c chr16:219 21964608 21994666 0.10458 6.450071 1.011093 0.156757 2.003316 202343_x NM_001862 | COX5B 1329 Hs.1342 202343_x 2 GO:00075 + NM_0018 cytochrome c oxidase subunit chr2:9826 98262520 98264656 -1.38656 6.451551 0.642605 0.099605 1.563332 221864_a NM_152288 | ORAI3 93129 Hs.46061 221864_a 16 GO:00160 + AW51746 ORAI calcium release-activated chr16:309 30960404 30966258 1.742498 6.45714 1.755233 0.271828 3.320964 221840_a NM_006504 | PTPRE 5791 Hs.12702 221840_a 10 GO:00064 + AA77517 protein tyrosine phosphatase, chr10:129 1.3E+08 1.3E+08 1.728046 6.464428 1.765218 0.273066 3.329812 216250_s NM_001143995 LPXN 9404 Hs.12547 216250_s 11 GO:00071 - X77598 leupaxin chr11:582 58294345 58345639 0.554635 6.465498 1.346943 0.208328 2.519573 220974_x NM_030971 | SFXN3 81855 Hs.28384 220974_x 10 GO:00068 + NM_0309 sideroflexin 3 chr10:102 1.03E+08 1.03E+08 1.362135 6.472154 0.748913 0.115713 1.681178 202970_a NM_003583 | DYRK2 8445 Hs.17313 202970_a 12 GO:00069 + AI192838 dual-specificity tyrosine-(Y)- chr12:680 68042511 68056443 -1.20796 6.4745 0.742195 0.114634 1.669278 212637_s NM_007013 | WWP1 11059 Hs.65518 212637_s 8 GO:00199 + AU15518 WW domain containing E3 chr8:8735 87354993 87480176 0.108871 6.480367 2.586652 0.399152 6.007933 221542_s NM_001003790 ERLIN2 11160 Hs.70549 221542_s 8 GO:00304 + T90773 ER lipid raft associated 2 chr8:3759 37594096 37604070 1.573754 6.483302 1.90186 0.293347 3.653404 203376_a NM_015891 | CDC40 51362 Hs.42814 203376_a 6 GO:00063 + BG528818 cell division cycle 40 homolog chr6:1105 1.11E+08 1.11E+08 -1.11732 6.48954 0.937125 0.144405 1.909596 212854_x NA NA NA NA 212854_x NA NA NA AB051480 NA chrNA:-1-- -1 -1 0.13639 6.498056 1.150201 0.177007 2.227908 212119_a NM_012249 | RHOQ 23433 Hs.70919 212119_a 2 GO:00061 + BF670447 ras homolog gene family, chr2:4676 46769866 46811825 0.045067 6.500419 1.359324 0.209113 2.534746 207233_s NM_000248 | MITF 4286 Hs.16601 207233_s 3 GO:00160 + NM_0002 microphthalmia-associated chr3:6978 69788632 70017486 -0.54291 6.505395 1.576351 0.242314 2.970525 217673_x NM_000516 | GNAS 2778 Hs.12589 217673_x 20 GO:00019 + AA65055 GNAS complex chr20:574 57414794 57486249 0.737808 6.5061 0.631952 0.097132 1.550037 206488_s NM_000072 | CD36 948 Hs.12094 206488_s 7 GO:00019 + NM_0000 CD36 molecule chr7:8023 80231503 80303732 -0.63716 6.507549 4.853917 0.74589 25.24597 36612_at NM_015159 | FAM168A 23201 Hs.47533 36612_at 11 NA - D87470 family with sequence similarity chr11:731 73117027 73309228 2.36295 6.507736 0.727472 0.111786 1.655586 214958_s NM_001127198 TMC6 11322 Hs.63222 214958_s 17 GO:00160 - AK021738 transmembrane channel-like 6 chr17:761 76108998 76128488 0.395576 6.513782 1.287289 0.197625 2.447818 213164_a NA NA NA NA 213164_a NA NA NA AI867198 NA chrNA:-1-- -1 -1 0.175206 6.527834 2.208409 0.338307 4.740696 202151_s NM_016172 | UBAC1 10422 Hs.9194 202151_s 9 GO:00199 - NM_0161 UBA domain containing 1 chr9:1388 1.39E+08 1.39E+08 -1.45237 6.53051 1.566795 0.239919 2.931952 203912_s NM_001009932 DNASE1L 1774 Hs.40192 203912_s X GO:00063 - NM_0067 I-like 1 chrX:1536 1.54E+08 1.54E+08 -1.01347 6.531181 0.850574 0.130233 1.799453 200970_s NM_014445 | SERP1 27230 Hs.51832 200970_s 3 GO:00064 - AL136807 stress-associated endoplasmic chr3:1502 1.5E+08 1.5E+08 -2.26435 6.535162 1.719899 0.263176 3.240132 203093_s NM_006351 | TIMM44 10469 Hs.46578 203093_s 19 GO:00066 - NM_0063 of inner chr19:799 7991603 8008708 -1.17951 6.537448 0.595483 0.091088 1.510142 205198_s NM_000052 | ATP7A 538 Hs.49641 205198_s X GO:00081 + NM_0000 ATPase, Cu++ transporting, chrX:7716 77166193 77305891 -0.80836 6.541622 1.711886 0.261691 3.267848 202594_a NM_001128208 LEPROTL1 23484 Hs.14658 202594_a 8 GO:00160 + NM_0153 overlapping chr8:2995 29952921 29965586 -1.308 6.542167 1.537813 0.235062 2.896258 214054_a NM_003974 | DOK2 9046 Hs.71215 214054_a 8 GO:00071 - AI828929 docking protein 2, 56kDa chr8:2176 21766383 21771205 0.285151 6.545903 2.333673 0.356509 4.840731 206631_a NM_000956 | PTGER2 5732 Hs.2090 206631_a 14 GO:00071 + NM_0009 prostaglandin E receptor 2 chr14:527 52781015 52795320 -0.61887 6.55064 2.802821 0.42787 6.93325 222150_s NM_017439 | PION 54103 Hs.18664 222150_s 7 NA - AK026747 pigeon homolog (Drosophila) chr7:7694 76940069 77045717 1.953555 6.554558 2.023549 0.308724 4.098793 203190_a NM_002496 | NDUFS8 4728 Hs.90443 203190_a 11 GO:00061 + NM_0024 NADH dehydrogenase chr11:677 67798093 67804114 -1.15656 6.561161 0.809229 0.123336 1.754685 209924_a NM_002988 | CCL18 6362 Hs.14396 209924_a 17 GO:00071 + AB000221 chemokine (C-C motif) ligand 18 chr17:343 34391642 34398840 -0.21613 6.561225 3.746852 0.57106 12.04237 204112_s NM_001024074 HNMT 3176 Hs.42151 204112_s 2 GO:00075 + NM_0068 histamine N-methyltransferase chr2:1387 1.39E+08 1.39E+08 -0.97793 6.564322 3.594686 0.54761 10.83232 201527_a NM_004231 | ATP6V1F 9296 Hs.78089 201527_a 7 GO:00068 + NM_0042 ATPase, H+ transporting, chr7:1285 1.29E+08 1.29E+08 -1.7455 6.566269 0.974608 0.148427 1.955684 210131_x NM_001035511 SDHC 6391 Hs.44447 210131_x 1 GO:00060 + D49737 succinate dehydrogenase chr1:1612 1.61E+08 1.61E+08 -0.19063 6.566622 0.784563 0.119477 1.721007 212230_a NM_003713 | PPAP2B 8613 Hs.40515 212230_a 1 GO:00015 - AV72566 phosphatidic chr1:5696 56960432 57045257 0.059085 6.570233 1.834082 0.27915 3.660213 220134_x NM_018166 | FAM176B 55194 Hs.87016 220134_x 1 GO:00160 - NM_0181 family with sequence similarity chr1:3678 36787631 36789755 1.141616 6.574217 1.048036 0.159416 2.068956 204466_s NM_000345 | SNCA 6622 Hs.21374 204466_s 4 GO:00017 - BG260394 synuclein, alpha (non A4 chr4:9064 90645250 90759447 -0.91973 6.578176 2.096044 0.318636 4.135403 205062_x NM_002892 | ARID4A 5926 Hs.16100 205062_x 14 GO:00063 + NM_0028 AT rich interactive domain 4A chr14:587 58765221 58840448 -0.82718 6.584054 1.666069 0.253046 3.226104 201862_s NM_001137550 LRRFIP1 9208 Hs.47177 201862_s 2 GO:00063 + NM_0047 leucine rich repeat (in FLII) chr2:2385 2.39E+08 2.39E+08 -1.56848 6.584151 1.704713 0.258912 3.18747 218268_a NM_001146213 TBC1D15 64786 Hs.28463 218268_a 12 GO:00323 + NM_0227 TBC1 domain family, member chr12:722 72233486 72320627 0.818585 6.614061 1.518362 0.229566 2.82281

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 212706_a NA NA NA NA 212706_a NA NA NA AB011110 NA chrNA:-1-- -1 -1 0.1178 6.614347 2.868802 0.433724 7.689472 217608_a NM_173829 | SFRS12IP 285672 Hs.69504 217608_a 5 GO:00063 - AW40876 SFRS12-interacting protein 1 chr5:6401 64013979 64064496 0.728714 6.614911 0.75684 0.114414 1.68796 222218_s NM_013439 | PILRA 29992 Hs.44440 222218_s 7 GO:00071 + AJ400843 paired immunoglobin-like type chr7:9997 99971067 99997722 2.014628 6.621807 1.540579 0.232652 2.889966 211067_s NM_001130831 GAS7 8522 Hs.46221 211067_s 17 GO:00510 - BC006454 growth arrest-specific 7 chr17:981 9813925 10101868 -0.07872 6.625526 2.454078 0.370398 5.25914 205801_s NM_001139488 RASGRP3 25780 Hs.14367 205801_s 2 GO:00001 + NM_0153 RAS guanyl releasing protein 3 chr2:3366 33661415 33789797 -0.72668 6.626242 1.410458 0.212859 2.672375 202749_a NM_001146218 WRB 7485 Hs.19830 202749_a 21 GO:00160 + NM_0046 tryptophan rich basic protein chr21:407 40752212 40769814 -1.2637 6.628093 0.998521 0.15065 1.987083 201126_s NM_001114617 MGAT1 4245 Hs.51981 201126_s 5 GO:00059 - NM_0024 mannosyl (alpha-1,3-)- chr5:1802 1.8E+08 1.8E+08 -2.07012 6.634832 0.76532 0.115349 1.696388 218437_s NM_020347 | LZTFL1 54585 Hs.30824 218437_s 3 NA - NM_0203 transcription chr3:4586 45865445 45883621 0.842998 6.641589 1.919072 0.288948 3.787052 211794_a NM_001465 | FYB 2533 Hs.37050 211794_a 5 GO:00071 - AF198052 FYN binding protein (FYB- chr5:3910 39105357 39219667 0.005611 6.646078 1.304781 0.196323 2.491079 212163_a NM_020738 | KIDINS22 57498 Hs.9873 212163_a 2 GO:00072 - AB033076 kinase D-interacting substrate, chr2:8868 8868986 8977755 0.050784 6.646877 1.281995 0.192872 2.414902 36994_at NM_001694 | ATP6V0C 527 Hs.38910 36994_at 16 GO:00068 + M62762 ATPase, H+ transporting, chr16:256 2563952 2570218 2.381715 6.648978 0.842429 0.126701 1.789331 219872_a NM_001031700 FAM198B 51313 Hs.56749 219872_a 4 GO:00001 - NM_0166 family with sequence similarity chr4:1590 1.59E+08 1.59E+08 1.088083 6.651071 3.458445 0.519983 11.7058 212347_x NM_006454 | MXD4 10608 Hs.65502 212347_x 4 GO:00001 - AA83143 MAX dimerization protein 4 chr4:2249 2249159 2263739 0.073356 6.654523 1.737602 0.261116 3.260704 217868_s NM_001077180 METTL9 51108 Hs.27958 217868_s 16 NA + NM_0160 methyltransferase like 9 chr16:216 21610855 21668791 0.764058 6.659025 0.835461 0.125463 1.779333 204446_s NM_000698 | ALOX5 240 Hs.89499 204446_s 10 GO:00551 + NM_0006 arachidonate 5-lipoxygenase chr10:458 45869628 45941561 -0.92292 6.671721 3.218533 0.482414 10.24334 205092_x NM_001123329 ZBTB1 22890 Hs.60514 205092_x 14 GO:00454 + NM_0149 zinc finger and BTB domain chr14:649 64971291 64991667 -0.82305 6.671831 0.959268 0.143779 1.94257 202959_a NM_000255 | MUT 4594 Hs.48552 202959_a 6 GO:00081 - AI433712 methylmalonyl Coenzyme A chr6:4939 49398993 49431031 -1.20995 6.67243 1.223733 0.183401 2.321048 211752_s NM_024407 | NDUFS7 374291 Hs.21191 211752_s 19 GO:00061 + BC005954 NADH dehydrogenase chr19:138 1383882 1395587 0.001194 6.674682 0.959795 0.143796 1.954566 206171_a NM_000677 | ADORA3 140 Hs.28134 206171_a 1 GO:00071 - NM_0006 adenosine A3 receptor chr1:1120 1.12E+08 1.12E+08 -0.67747 6.677065 3.058357 0.458039 7.769955 203674_a NM_014877 | HELZ 9931 Hs.37014 203674_a 17 GO:00056 - NM_0148 helicase with zinc finger chr17:650 65066554 65241319 -1.0575 6.687033 1.484877 0.222053 2.819171 200657_a NM_001152 | SLC25A5 292 Hs.63228 200657_a X GO:00444 + NM_0011 solute carrier family 25 chrX:1186 1.19E+08 1.19E+08 -3.02992 6.690879 1.199987 0.179347 2.286345 213537_a NM_033554 | HLA- 3113 Hs.34727 213537_a 6 GO:00025 - AI128225 major histocompatibility chr6:3303 33032793 33041378 0.221297 6.694456 1.004033 0.14998 2.001642 212421_a NM_001009880 C22orf9 23313 Hs.59220 212421_a 22 GO:00055 - AB023147 open reading chr22:455 45588122 45636650 0.082839 6.695256 2.127376 0.317744 4.307461 204334_a NM_003709 | KLF7 8609 Hs.47122 204334_a 2 GO:00063 - AA48867 Kruppel-like factor 7 chr2:2079 2.08E+08 2.08E+08 -0.94088 6.696485 1.275815 0.19052 2.422966 204861_s NM_004536 | NAIP 4671 Hs.65450 204861_s 5 GO:00069 - NM_0045 NLR family, inhibitory chr5:7026 70264309 70320941 -0.85711 6.697298 2.348342 0.35064 5.284871 205174_s NM_012413 | QPCT 25797 Hs.79033 205174_s 2 GO:00064 + NM_0124 glutaminyl-peptide chr2:3757 37571752 37600464 -0.81173 6.714691 4.076409 0.607088 18.24417 218252_a NM_001098525 CKAP2 26586 Hs.44402 218252_a 13 GO:00069 + NM_0182 cytoskeleton associated protein chr13:530 53029494 53050763 0.816351 6.71781 1.835034 0.27316 3.584556 50277_at NM_001001560 GGA1 26088 Hs.49915 50277_at 22 GO:00161 + AW00144 golgi-associated, gamma chr22:380 38004480 38014127 2.870894 6.718739 1.347097 0.200499 2.569249 212914_a NM_175709 | CBX7 23492 Hs.35641 212914_a 22 GO:00063 - AV64836 chromobox homolog 7 chr22:395 39526789 39548538 0.144233 6.719045 1.718748 0.255802 3.278358 209879_a NM_003006 | SELPLG 6404 Hs.59101 209879_a 12 GO:00071 - AI741056 P ligand chr12:109 1.09E+08 1.09E+08 -0.22142 6.721 1.241983 0.184791 2.367248 216199_s NM_005922 | MAP3K4 4216 Hs.39042 216199_s 6 GO:00001 + AL109942 mitogen-activated protein chr6:1614 1.61E+08 1.62E+08 0.548668 6.726772 1.739604 0.258609 3.390479 218855_a NM_001136053 TPRA1 131601 Hs.6418 218855_a 3 GO:00066 - NM_0163 transmembrane protein, chr3:1272 1.27E+08 1.27E+08 0.908007 6.728087 1.082722 0.160926 2.118809 218298_s NM_001102366 C14orf15 80017 Hs.30984 218298_s 14 GO:00057 + NM_0249 chromosome 14 open reading chr14:915 91580356 91691703 0.822684 6.730099 1.240122 0.184265 2.360931 213392_a NM_153208 | IQCK 124152 Hs.46021 213392_a 16 NA + AW07022 IQ motif containing K chr16:197 19727777 19868857 0.203529 6.733051 2.275368 0.33794 5.032882 219968_a NM_016089 | ZNF589 51385 Hs.17260 219968_a 3 GO:00063 + NM_0160 zinc finger protein 589 chr3:4828 48282595 48312477 1.107581 6.743409 1.278731 0.189627 2.441207 218039_a NM_001129897 NUSAP1 51203 Hs.61509 218039_a 15 GO:00002 + NM_0163 nucleolar and spindle chr15:416 41624925 41673247 0.787288 6.75181 1.150412 0.170386 2.229889 212206_s NM_012412 | H2AFV 94239 Hs.48818 212206_s 7 GO:00063 - BF343852 H2A histone family, member V chr7:4487 44873212 44887725 0.055887 6.752442 1.323953 0.19607 2.518549 215739_s NM_006322 | TUBGCP3 10426 Hs.22415 215739_s 13 GO:00070 - AJ003062 tubulin, gamma complex chr13:113 1.13E+08 1.13E+08 0.491856 6.77067 0.82791 0.122279 1.777194 204497_a NM_001116 | ADCY9 115 Hs.39186 204497_a 16 GO:00061 - AB011092 adenylate cyclase 9 chr16:401 4012652 4166186 -0.91451 6.777442 2.550973 0.376392 5.715146 218271_s NM_001037639 PARL 55486 Hs.47846 218271_s 3 GO:00160 - NM_0186 presenilin associated, chr3:1835 1.84E+08 1.84E+08 0.818963 6.777623 0.976051 0.144011 1.957965 221689_s NM_153681 | PIGP 51227 Hs.65656 221689_s 21 GO:00081 - AB035745 phosphatidylinositol glycan chr21:384 38437663 38445458 1.644989 6.779178 1.13728 0.167761 2.196566 212518_a NM_012398 | PIP5K1C 23396 Hs.28217 212518_a 19 GO:00074 - AB011161 phosphatidylinositol-4- chr19:363 3630181 3700445 0.094593 6.782204 0.823136 0.121367 1.767453 208755_x NA NA NA NA 208755_x NA NA NA BF312331 NA chrNA:-1-- -1 -1 -0.35853 6.791105 1.012804 0.149137 2.009296 212166_a NM_001100161 XPO7 23039 Hs.17268 212166_a 8 GO:00066 + H38643 exportin 7 chr8:2177 21777179 21864095 0.051108 6.793848 1.190645 0.175253 2.283819 214042_s NM_000983 | RPL22 6146 Hs.51532 214042_s 1 GO:00064 - AW07199 ribosomal protein L22 chr1:6245 6245080 6259679 0.283673 6.794631 0.885363 0.130303 1.850735 218107_a NM_001115113 WDR26 80232 Hs.49787 218107_a 1 GO:00057 - NM_0251 WD repeat domain 26 chr1:2245 2.25E+08 2.25E+08 0.796357 6.796038 0.977881 0.14389 1.969784

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 200780_x NM_000516 | GNAS 2778 Hs.12589 200780_x 20 GO:00019 + NM_0005 GNAS complex locus chr20:574 57414794 57486249 -2.63327 6.797806 0.792225 0.116541 1.727927 219491_a NM_024036 | LRFN4 78999 Hs.20997 219491_a 11 GO:00160 + NM_0240 leucine rich repeat and chr11:666 66624875 66627945 1.015254 6.802867 0.850271 0.124987 1.800495 204923_a NM_018990 | SASH3 54440 Hs.61469 204923_a X NA + AL023653 SAM and SH3 domain containing chrX:1289 1.29E+08 1.29E+08 -0.84773 6.808873 1.354134 0.198878 2.534611 212672_a NM_000051 | ATM 472 Hs.36743 212672_a 11 GO:00017 + U82828 ataxia telangiectasia mutated chr11:108 1.08E+08 1.08E+08 0.113347 6.815423 1.502211 0.220413 2.870222 213552_a NM_015554 | GLCE 26035 Hs.18300 213552_a 15 GO:00150 + W87398 glucuronic acid epimerase chr15:694 69452972 69564544 0.223068 6.815632 1.677173 0.246077 3.221138 212308_a NM_015097 | CLASP2 23122 Hs.10861 212308_a 3 GO:00070 - AL137636 cytoplasmic linker associated chr3:3353 33537740 33759848 0.068736 6.816227 1.336538 0.196082 2.535138 208661_s NM_001001894 TTC3 7267 Hs.36821 208661_s 21 GO:00065 + AW51069 tetratricopeptide repeat chr21:384 38445570 38575406 -0.36987 6.823178 2.20639 0.323367 4.540988 201029_s NM_001122898 CD99 4267 Hs.65334 201029_s X chrY:2609 + NM_0024 CD99 molecule chrX:2609 2609227 2659348 -2.18157 6.82319 1.018868 0.149324 2.025096 211383_s NM_014023 | WDR37 22884 Hs.18849 211383_s 10 NA + AL136827 WD repeat domain 37 chr10:110 1102775 1178237 -0.04247 6.82372 1.270554 0.186197 2.401825 201740_a NM_004551 | NDUFS3 4722 Hs.50252 201740_a 11 GO:00061 + NM_0045 NADH dehydrogenase chr11:476 47600561 47606115 -1.62836 6.827564 1.168465 0.171139 2.236175 201005_a NM_001769 | CD9 928 Hs.11428 201005_a 12 GO:00071 + NM_0017 CD9 molecule chr12:630 6309554 6347427 -2.21219 6.827815 3.743416 0.54826 13.54791 206567_s NM_016436 | PHF20 51230 Hs.51704 206567_s 20 GO:00454 + NM_0164 PHD finger protein 20 chr20:343 34359922 34538288 -0.62697 6.833115 1.107858 0.162131 2.159616 221824_s NM_001002265 MARCH8 220972 Hs.49948 221824_s 10 GO:00199 - AA77017 membrane-associated ring chr10:459 45952816 46090354 1.71835 6.841821 1.342821 0.196267 2.557711 219358_s NM_018404 | ADAP2 55803 Hs.51406 219358_s 17 GO:00075 + NM_0184 ArfGAP with dual PH domains 2 chr17:292 29248753 29286209 0.991306 6.843118 1.421661 0.207751 2.680807 204703_a NM_006531 | IFT88 8100 Hs.18737 204703_a 13 GO:00017 + NM_0065 intraflagellar transport 88 chr13:211 21141207 21265574 -0.88166 6.853301 1.147855 0.167489 2.228929 213263_s NM_001098620 PCBP2 5094 Hs.54627 213263_s 12 GO:00083 + AW02515 poly(rC) binding protein 2 chr12:538 53845885 53874945 0.187476 6.858589 1.048959 0.152941 2.059679 202897_a NM_001040022 SIRPA 140885 Hs.58102 202897_a 20 GO:00071 + AB023430 signal-regulatory protein alpha chr20:187 1874812 1920539 -1.2254 6.861458 1.317361 0.191994 2.470942 200696_s NM_000177 | GSN 2934 Hs.52237 200696_s 9 GO:00510 + NM_0001 gelsolin (amyloidosis, Finnish chr9:1240 1.24E+08 1.24E+08 -2.86794 6.864668 0.806261 0.117451 1.750091 219007_a NM_198887 | NUP43 348995 Hs.51037 219007_a 6 GO:00070 - NM_0246 nucleoporin 43kDa chr6:1500 1.5E+08 1.5E+08 0.932809 6.86538 1.063755 0.154945 2.095395 207037_a NM_003839 | TNFRSF1 8792 Hs.20404 207037_a 18 GO:00015 + NM_0038 tumor necrosis factor receptor chr18:599 59992547 60053502 -0.56676 6.865999 2.062824 0.30044 4.054925 218304_s NM_022776 | OSBPL11 114885 Hs.47744 218304_s 3 GO:00068 - NM_0227 oxysterol binding protein-like chr3:1252 1.25E+08 1.25E+08 0.823634 6.875149 1.928836 0.280552 3.770675 202017_a NM_000120 | EPHX1 2052 Hs.89649 202017_a 1 GO:00096 + NM_0001 epoxide hydrolase 1, chr1:2259 2.26E+08 2.26E+08 -1.50252 6.881594 2.14336 0.311463 4.556064 203286_a NM_014901 | RNF44 22838 Hs.43488 203286_a 5 GO:00055 - NM_0149 ring finger protein 44 chr5:1759 1.76E+08 1.76E+08 -1.13592 6.88427 1.407236 0.204413 2.642868 215528_a NA NA NA NA 215528_a NA NA NA AL049390 NA chrNA:-1-- -1 -1 0.465706 6.884622 2.662729 0.386765 6.642539 215834_x NM_001082959 SCARB1 949 Hs.70921 215834_x 12 GO:00019 - AV70813 scavenger receptor class B, chr12:125 1.25E+08 1.25E+08 0.503123 6.885774 3.265368 0.474219 10.54669 204577_s NM_015041 | CLUAP1 23059 Hs.15599 204577_s 16 GO:00056 + NM_0247 clusterin associated protein 1 chr16:355 3550962 3586583 -0.90178 6.888207 0.569155 0.082627 1.484817 200709_a NM_000801 | FKBP1A 2280 Hs.47193 200709_a 20 GO:00030 - NM_0008 FK506 binding protein 1A, 12kDa chr20:135 1352360 1373816 -2.82368 6.890018 1.076221 0.1562 2.111637 201949_x NM_004930 | CAPZB 832 Hs.43276 201949_x 1 GO:00300 - AL572341 capping protein (actin filament) chr1:1966 19665266 19812066 -1.53016 6.897847 0.885404 0.128359 1.851946 202217_a NA NA NA NA 202217_a NA NA NA NM_0046 NA chrNA:-1-- -1 -1 -1.42725 6.898792 1.058643 0.153453 2.079149 200962_a NM_000993 | RPL31 6160 Hs.46947 200962_a 2 GO:00064 + AI348010 ribosomal protein L31 chr2:1016 1.02E+08 1.02E+08 -2.27634 6.899505 1.057359 0.153251 2.07409 212990_a NM_001160302 SYNJ1 8867 Hs.47363 212990_a 21 GO:00163 - AB020717 synaptojanin 1 chr21:340 34001068 34100351 0.153688 6.900869 2.170276 0.314493 4.455473 213158_a NA NA NA NA 213158_a NA NA NA AA04517 NA chrNA:-1-- -1 -1 0.174491 6.902932 1.715107 0.248461 3.24023 212040_a NM_006464 | TGOLN2 10618 Hs.59338 212040_a 2 GO:00058 - BG249599 trans-golgi network protein 2 chr2:8554 85545146 85555374 0.03518 6.908552 1.974553 0.285813 3.829639 200784_s NM_002332 | LRP1 4035 Hs.16275 200784_s 12 GO:00066 + BF304759 low density lipoprotein chr12:575 57522281 57607123 -2.6216 6.909773 1.58736 0.229727 2.993677 211676_s NM_000416 | IFNGR1 3459 Hs.52041 211676_s 6 GO:00096 - AF056979 interferon gamma receptor 1 chr6:1375 1.38E+08 1.38E+08 -0.00747 6.917301 1.809792 0.261633 3.458237 207594_s NM_001160302 SYNJ1 8867 Hs.47363 207594_s 21 GO:00163 - NM_0038 synaptojanin 1 chr21:340 34001068 34100351 -0.49853 6.922446 1.355106 0.195755 2.571946 221589_s NM_005589 | ALDH6A1 4329 Hs.29397 221589_s 14 GO:00551 - AW61240 aldehyde dehydrogenase 6 chr14:745 74526873 74551196 1.595853 6.92677 2.733643 0.394649 6.391733 218259_a NM_014048 | MKL2 57496 Hs.49143 218259_a 16 GO:00017 + NM_0140 MKL/myocardin-like 2 chr16:141 14165195 14360629 0.817344 6.932663 1.756202 0.253323 3.315974 200699_a NM_001100603 KDELR2 11014 Hs.65455 200699_a 7 GO:00161 - BE962456 KDEL (Lys-Asp-Glu-Leu) chr7:6500 6500712 6523849 -2.85897 6.934547 1.1559 0.166687 2.242938 216640_s NM_005742 | PDIA6 10130 Hs.21210 216640_s 2 GO:00064 - AK026926 protein disulfide isomerase chr2:1092 10923518 10952960 0.604022 6.943164 1.265039 0.182199 2.416166 203887_s NM_000361 | THBD 7056 Hs.2030 203887_s 20 GO:00075 - NM_0003 chr20:230 23026270 23030301 -1.01758 6.949104 1.767438 0.25434 3.415379 200981_x NM_000516 | GNAS 2778 Hs.12589 200981_x 20 GO:00019 + NM_0165 GNAS complex locus chr20:574 57414794 57486249 -2.24549 6.953392 0.892866 0.128407 1.859527 31826_at NM_015258 | FKBP15 23307 Hs.52235 31826_at 9 GO:00064 - AB014574 FK506 binding protein 15, chr9:1159 1.16E+08 1.16E+08 2.21015 6.961376 0.951353 0.136662 1.932589 201009_s NM_006472 | TXNIP 10628 Hs.53397 201009_s 1 GO:00096 + AI439556 thioredoxin interacting protein chr1:1454 1.45E+08 1.45E+08 -2.20635 6.966797 2.539903 0.364573 5.982892 201988_s NM_001310 | CREBL2 1389 Hs.59115 201988_s 12 GO:00071 + BF438056 cAMP responsive element chr12:127 12764830 12798041 -1.51443 6.974379 1.678336 0.240643 3.263367 217286_s NM_022477 | NDRG3 57446 Hs.43733 217286_s 20 GO:00072 - BC001805 NDRG family member 3 chr20:352 35280169 35374481 0.685593 6.976064 1.890683 0.271024 3.627983

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 204142_a NM_001126123 ENOSF1 55556 Hs.36976 204142_a 18 GO:00081 - NM_0175 enolase superfamily member 1 chr18:673 673860 712662 -0.97254 6.981084 2.035518 0.291576 3.990915 201186_a NM_002337 | LRPAP1 4043 Hs.53313 201186_a 4 GO:00064 - NM_0023 low density lipoprotein chr4:3514 3514289 3534224 -2.00767 6.988321 1.513955 0.216641 2.893866 212949_a NM_015341 | NCAPH 23397 Hs.30804 212949_a 2 GO:00002 + D38553 non-SMC condensin I complex, chr2:9700 97001483 97041274 0.148641 7.000407 1.920714 0.274372 3.786237 214820_a NM_001007246 BRWD1 54014 Hs.65474 214820_a 21 GO:00063 - AJ002572 bromodomain and WD repeat chr21:406 40668365 40685556 0.378334 7.018537 0.752455 0.10721 1.683097 218559_s NM_005461 | MAFB 9935 Hs.16948 218559_s 20 GO:00073 - NM_0054 v- musculoaponeurotic chr20:393 39314518 39317876 0.861051 7.02255 1.939277 0.27615 3.743929 212361_s NM_001135765 ATP2A2 488 Hs.50675 212361_s 12 GO:00081 + AW19007 ATPase, Ca++ transporting, chr12:110 1.11E+08 1.11E+08 0.07511 7.044225 2.020288 0.286801 3.999391 205068_s NM_001135608 ARHGAP2 23092 Hs.65466 205068_s 5 GO:00300 + BE671084 Rho GTPase activating protein chr5:1421 1.42E+08 1.43E+08 -0.82632 7.044309 2.337506 0.331829 5.178551 211825_s NA NA NA NA 211825_s NA NA NA AF327066 NA chrNA:-1-- -1 -1 0.009109 7.050819 1.796738 0.254827 3.462103 207760_s NM_001077261 NCOR2 9612 Hs.13751 207760_s 12 GO:00105 - NM_0063 co-repressor 2 chr12:124 1.25E+08 1.25E+08 -0.47877 7.054692 1.599741 0.226763 3.043535 212273_x NM_000516 | GNAS 2778 Hs.12589 212273_x 20 GO:00019 + AI591100 GNAS complex locus chr20:574 57414794 57486249 0.064612 7.058552 0.894488 0.126724 1.859238 204293_a NM_000199 | SGSH 6448 Hs.31074 204293_a 17 GO:00060 - NM_0001 N-sulfoglucosamine chr17:781 78183080 78194199 -0.94807 7.059602 1.377248 0.195089 2.617507 202590_s NM_002611 | PDK2 5164 Hs.25666 202590_s 17 GO:00071 + AL574319 pyruvate dehydrogenase chr17:481 48172695 48188422 -1.30939 7.05978 0.914723 0.129568 1.884636 203126_a NM_014214 | IMPA2 3613 Hs.36799 203126_a 18 GO:00071 + NM_0142 inositol(myo)-1(or 4)- chr18:119 11981454 12030876 -1.17155 7.060057 2.605879 0.369102 6.313147 219471_a NM_025113 | C13orf18 80183 Hs.98117 219471_a 13 NA - NM_0251 chromosome 13 open reading chr13:469 46916138 46961635 1.011603 7.066854 1.284711 0.181794 2.456231 209150_s NM_001014842 TM9SF1 10548 Hs.91586 209150_s 14 GO:00069 - U94831 transmembrane 9 superfamily chr14:246 24659244 24664882 -0.31125 7.071877 0.957351 0.135374 1.93996 218184_a NM_001007466 TULP4 56995 Hs.48699 218184_a 6 GO:00199 + NM_0202 tubby like protein 4 chr6:1587 1.59E+08 1.59E+08 0.80705 7.074098 1.300393 0.183825 2.477066 219179_a NM_001079520 DACT1 51339 Hs.48950 219179_a 14 GO:00160 + NM_0166 dapper, antagonist of beta- chr14:591 59104756 59115036 0.960376 7.081321 3.794096 0.535789 15.03955 221565_s NM_015916 | CALHM2 51063 Hs.24154 221565_s 10 GO:00160 - BC000039 calcium homeostasis modulator chr10:105 1.05E+08 1.05E+08 1.584247 7.082278 1.253759 0.177028 2.378334 202803_s NM_000211 | ITGB2 3689 Hs.37595 202803_s 21 GO:00069 - NM_0002 integrin, beta 2 (complement chr21:463 46305867 46348753 -1.24877 7.089785 1.649344 0.232637 3.088233 211419_s NM_001039936 CHN2 1124 Hs.65461 211419_s 7 GO:00072 + L29126 chimerin (chimaerin) 2 chr7:2923 29234120 29553943 -0.03878 7.094697 1.996019 0.28134 4.010261 214938_x NM_002128 | HMGB1 3146 Hs.43410 214938_x 13 GO:00071 - AF283771 high-mobility group box 1 chr13:310 31032880 31040081 0.393156 7.095133 1.090725 0.153729 2.120345 203845_a NM_003884 | KAT2B 8850 Hs.53305 203845_a 3 GO:00081 + AV72744 K(lysine) acetyltransferase 2B chr3:2008 20081523 20195894 -1.02445 7.101312 1.176452 0.165667 2.249504 219715_s NM_001008744 TDP1 55775 Hs.20994 219715_s 14 GO:00000 + NM_0183 tyrosyl-DNA chr14:904 90422245 90511106 1.056601 7.104798 0.737018 0.103735 1.665768 213787_s NM_006579 | EBP 10682 Hs.30619 213787_s X GO:00015 + AV70240 emopamil binding protein chrX:4838 48380163 48387102 0.252501 7.121147 0.983882 0.138163 1.973651 201737_s NM_005885 | MARCH6 10299 Hs.43286 201737_s 5 GO:00199 + NM_0058 membrane-associated ring chr5:1035 10353827 10435491 -1.62982 7.127318 2.408968 0.337991 5.525082 218218_a NM_018171 | APPL2 55198 Hs.50660 218218_a 12 GO:00071 - NM_0181 adaptor protein, chr12:105 1.06E+08 1.06E+08 0.811725 7.137681 2.317954 0.324749 4.865211 209949_a NM_000433 | NCF2 4688 Hs.58755 209949_a 1 GO:00069 - BC001606 neutrophil cytosolic factor 2 chr1:1835 1.84E+08 1.84E+08 -0.21284 7.144678 3.37706 0.472668 9.497601 202603_a NA NA NA NA 202603_a NA NA NA N51370 NA chrNA:-1-- -1 -1 -1.30538 7.146235 1.884022 0.263638 3.625176 208858_s NM_015292 | ESYT1 23344 Hs.63272 208858_s 12 GO:00160 + BC004998 extended -like chr12:565 56522053 56538452 -0.34645 7.149592 1.734633 0.24262 3.28535 202663_a NM_001077269 WIPF1 7456 Hs.12806 202663_a 2 GO:00300 - AI005043 WAS/WASL interacting protein chr2:1754 1.75E+08 1.76E+08 -1.28735 7.150269 1.431951 0.200265 2.698162 211730_s NM_021128 | POLR2L 5441 Hs.44107 211730_s 11 GO:00063 - BC005903 polymerase (RNA) II (DNA chr11:839 839721 842529 -0.00139 7.151181 0.983146 0.13748 1.980547 202389_s NM_002111 | HTT 3064 Hs.51845 202389_s 4 GO:00000 + L12392 huntingtin chr4:3076 3076407 3245686 -1.37138 7.151629 0.724442 0.101297 1.653502 34406_at NM_001100913 PACS2 23241 Hs.52562 34406_at 14 GO:00069 + AB011174 phosphofurin acidic cluster chr14:105 1.06E+08 1.06E+08 2.295312 7.163106 0.924604 0.129079 1.898792 216032_s NM_015966 | ERGIC3 51614 Hs.47255 216032_s 20 GO:00161 + AF091085 ERGIC and golgi 3 chr20:341 34129777 34145404 0.527752 7.163685 1.138654 0.158948 2.191168 209542_x NM_000618 | IGF1 3479 Hs.16056 209542_x 12 GO:00062 - M29644 insulin-like growth factor 1 chr12:102 1.03E+08 1.03E+08 -0.26226 7.164821 2.480029 0.34614 5.651431 204849_a NM_006602 | TCFL5 10732 Hs.12624 204849_a 20 GO:00063 - NM_0066 -like 5 (basic chr20:614 61472467 61493115 -0.8588 7.16518 2.527595 0.352761 5.564486 204059_s NM_002395 | ME1 4199 Hs.21160 204059_s 6 GO:00059 - NM_0023 malic 1, NADP(+)- chr6:8392 83920111 84140779 -0.98722 7.16543 2.374076 0.331324 5.25378 206219_s NM_005428 | VAV1 7409 Hs.11623 206219_s 19 GO:00069 + NM_0054 vav 1 guanine nucleotide chr19:677 6772721 6857371 -0.67138 7.171837 0.937717 0.13075 1.913556 214754_a NM_144993 | TET3 200424 Hs.51610 214754_a 2 GO:00551 + AB007861 tet oncogene family member 3 chr2:7427 74273449 74335300 0.370342 7.177128 0.771583 0.107506 1.707099 208248_x NM_001142276 APLP2 334 Hs.37024 208248_x 11 GO:00019 + NM_0016 amyloid beta (A4) precursor- chr11:129 1.3E+08 1.3E+08 -0.4197 7.17834 1.791323 0.249546 3.408133 213553_x NM_001645 | APOC1 341 Hs.11067 213553_x 19 GO:00066 + W79394 apolipoprotein C-I chr19:454 45417920 45422606 0.223219 7.178491 0.875013 0.121894 1.835214 200743_s NM_000391 | TPP1 1200 Hs.52345 200743_s 11 GO:00065 - NM_0003 tripeptidyl peptidase I chr11:663 6633996 6640692 -2.72729 7.199365 1.23241 0.171183 2.333216 220094_s NM_001031713 CCDC90A 63933 Hs.21404 220094_s 6 GO:00160 - NM_0221 coiled-coil domain containing chr6:1379 13791020 13814789 1.133091 7.200991 1.249586 0.17353 2.393615 210830_s NM_000305 | PON2 5445 Hs.53007 210830_s 7 GO:00194 - AF001602 paraoxonase 2 chr7:9503 95034174 95064384 -0.10569 7.20305 1.787921 0.248217 3.516487 221543_s NM_001003790 ERLIN2 11160 Hs.70549 221543_s 8 GO:00304 + AL442077 ER lipid raft associated 2 chr8:3759 37594096 37604070 1.574369 7.203737 2.587563 0.359197 5.780148 218197_s NM_018002 | OXR1 55074 Hs.14877 218197_s 8 GO:00069 + NM_0180 oxidation resistance 1 chr8:1072 1.07E+08 1.08E+08 0.808802 7.20861 1.1987 0.166287 2.29753

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 219607_s NM_024021 | MS4A4A 51338 Hs.32596 219607_s 11 GO:00160 + NM_0240 membrane-spanning 4- chr11:600 60048138 60076444 1.03557 7.211299 5.234324 0.72585 34.21695 218716_x NM_001123226 MTO1 25821 Hs.34761 218716_x 6 GO:00080 + NM_0121 mitochondrial translation chr6:7417 74171453 74211177 0.885901 7.216035 0.636054 0.088145 1.554018 200617_a NM_014730 | MLEC 9761 Hs.72317 200617_a 12 GO:00059 + NM_0147 malectin chr12:121 1.21E+08 1.21E+08 -3.2304 7.217382 2.0604 0.285478 4.109814 212124_a NM_020338 | ZMIZ1 57178 Hs.19311 212124_a 10 GO:00015 + AF070622 zinc finger, MIZ-type containing chr10:808 80828791 81076285 0.045731 7.218493 3.155072 0.437082 8.568278 211557_x NM_001145211 SLCO2B1 11309 Hs.7884 211557_x 11 GO:00068 + AF205073 solute carrier organic anion chr11:748 74862039 74917444 -0.02207 7.221169 2.87103 0.397585 7.573172 202752_x NM_012244 | SLC7A8 23428 Hs.59664 202752_x 14 GO:00065 - NM_0122 solute carrier family 7 (cationic chr14:235 23594505 23652849 -1.26306 7.221422 2.054586 0.284513 4.097975 219679_s NM_016628 | WAC 51322 Hs.72313 219679_s 10 GO:00056 + NM_0186 WW domain containing adaptor chr10:288 28821426 28909921 1.049611 7.227706 1.118036 0.154688 2.182974 213687_s NM_000996 | RPL35A 6165 Hs.52963 213687_s 3 GO:00063 + BE968801 ribosomal protein L35a chr3:1976 1.98E+08 1.98E+08 0.239602 7.264209 0.773118 0.106428 1.711772 205884_a NM_000885 | ITGA4 3676 Hs.44095 205884_a 2 GO:00071 + NM_0008 integrin, alpha 4 (antigen chr2:1823 1.82E+08 1.82E+08 -0.71511 7.265681 2.114073 0.290967 4.422819 204146_a NM_001130862 RAD51AP 10635 Hs.50455 204146_a 12 GO:00007 + BE966146 RAD51 associated protein 1 chr12:464 4647949 4669212 -0.97184 7.300664 2.213069 0.303133 4.514422 200707_a NM_001001329 PRKCSH 5589 Hs.61083 200707_a 19 GO:00072 + NM_0027 protein kinase C substrate 80K- chr19:115 11546268 11561780 -2.83287 7.300868 1.309255 0.179329 2.484538 202368_s NM_012288 | TRAM2 9697 Hs.52018 202368_s 6 GO:00150 - AI986461 translocation associated chr6:5236 52362201 52441862 -1.37802 7.315273 1.435418 0.196222 2.679488 203104_a NM_005211 | CSF1R 1436 Hs.58621 203104_a 5 GO:00071 - NM_0052 colony stimulating factor 1 chr5:1494 1.49E+08 1.49E+08 -1.17655 7.318652 2.122599 0.290026 4.244511 202847_a NM_001018073 PCK2 5106 Hs.75812 202847_a 14 GO:00060 + NM_0045 phosphoenolpyruvate chr14:245 24563482 24569765 -1.23786 7.31977 1.172915 0.160239 2.262395 218491_s NM_001037304 THYN1 29087 Hs.13645 218491_s 11 GO:00056 - NM_0141 thymocyte nuclear protein 1 chr11:134 1.34E+08 1.34E+08 0.851239 7.323555 1.127497 0.153955 2.197019 213385_a NM_001039936 CHN2 1124 Hs.65461 213385_a 7 GO:00072 + AK026415 chimerin (chimaerin) 2 chr7:2923 29234120 29553943 0.202741 7.328818 3.645374 0.497403 12.38273 200935_a NM_004343 | CALR 811 Hs.51516 200935_a 19 GO:00001 + NM_0043 calreticulin chr19:130 13049413 13055304 -2.32001 7.330735 1.318888 0.179912 2.476929 201492_s NM_001035267 RPL41 6171 Hs.15716 201492_s 12 GO:00064 + NM_0211 ribosomal protein L41 chr12:565 56510373 56511615 -1.76668 7.332375 0.444781 0.06066 1.361014 218221_a NM_001668 | ARNT 405 Hs.63244 218221_a 1 GO:00016 - AL042842 aryl hydrocarbon receptor chr1:1507 1.51E+08 1.51E+08 0.812159 7.338995 0.836504 0.113981 1.787787 203718_a NM_001166111 PNPLA6 10908 Hs.63186 203718_a 19 GO:00015 + NM_0067 patatin-like chr19:759 7599037 7626653 -1.04889 7.33973 1.285857 0.175191 2.458456 204735_a NM_001111307 PDE4A 5141 Hs.89901 204735_a 19 GO:00071 + NM_0062 phosphodiesterase 4A, cAMP- chr19:105 10531332 10580307 -0.87657 7.341037 1.602669 0.218316 3.036046 218633_x NM_018394 | ABHD10 55347 Hs.47711 218633_x 3 GO:00057 + NM_0183 abhydrolase domain containing chr3:1116 1.12E+08 1.12E+08 0.872561 7.343139 1.380244 0.187964 2.590416 202191_s NM_001130831 GAS7 8522 Hs.46221 202191_s 17 GO:00510 - BE439987 growth arrest-specific 7 chr17:981 9813925 10101868 -1.43706 7.343944 3.03251 0.412927 8.081814 214924_s NM_001042646 TRAK1 22906 Hs.53571 214924_s 3 GO:00063 + AK000754 trafficking protein, kinesin chr3:4213 42132745 42267267 0.391338 7.34566 1.205943 0.164171 2.309033 208662_s NM_001001894 TTC3 7267 Hs.36821 208662_s 21 GO:00065 + AI885338 tetratricopeptide repeat chr21:384 38445570 38575406 -0.36976 7.350358 2.422993 0.329643 5.38791 205479_s NM_001145031 PLAU 5328 Hs.77274 205479_s 10 GO:00015 + NM_0026 plasminogen activator, chr10:756 75670861 75677256 -0.77006 7.351571 1.665422 0.22654 3.203893 205715_a NM_004334 | BST1 683 Hs.72034 205715_a 4 GO:00081 + NM_0043 bone marrow stromal cell chr4:1570 15704572 15733795 -0.73827 7.3525 1.284495 0.174702 2.447765 202812_a NM_000152 | GAA 2548 Hs.1437 202812_a 17 GO:00000 + NM_0001 glucosidase, alpha; acid chr17:780 78075354 78093678 -1.24647 7.354908 1.844733 0.250817 3.53311 60471_at NA NA NA NA 60471_at NA NA NA AA62513 NA chrNA:-1-- -1 -1 3.249501 7.35985 2.265878 0.30787 4.935388 221268_s NM_030791 | SGPP1 81537 Hs.24678 221268_s 14 GO:00069 - NM_0307 sphingosine-1-phosphate chr14:641 64150936 64194756 1.462594 7.3609 2.190307 0.29756 4.463223 222212_s NM_022075 | LASS2 29956 Hs.71310 222212_s 1 GO:00063 - AK001105 LAG1 homolog, ceramide chr1:1509 1.51E+08 1.51E+08 2.008948 7.363112 1.120827 0.152222 2.166614 204346_s NM_007182 | RASSF1 11186 Hs.47627 204346_s 3 GO:00070 - NM_0071 Ras association (RalGDS/AF-6) chr3:5036 50367216 50378367 -0.93888 7.367086 0.973425 0.132132 1.964951 212289_a NM_001083625 ANKRD12 23253 Hs.46458 212289_a 18 GO:00056 + AB020681 ankyrin repeat domain 12 chr18:913 9136757 9285206 0.066531 7.371141 0.853115 0.115737 1.808378 209447_a NM_015293 | SYNE1 23345 Hs.12967 209447_a 6 GO:00069 - AF043290 spectrin repeat containing, chr6:1524 1.52E+08 1.53E+08 -0.27422 7.372049 2.084266 0.282725 4.120462 216483_s NM_019107 | C19orf10 56005 Hs.46564 216483_s 19 GO:00082 - AC005339 open reading chr19:465 4657565 4670415 0.583834 7.374175 0.959258 0.130083 1.939756 221820_s NM_032188 | MYST1 84148 Hs.53380 221820_s 16 GO:00063 + AK024102 MYST histone acetyltransferase chr16:311 31128984 31142713 1.716216 7.387613 1.00697 0.136305 2.005293 219456_s NM_024832 | RIN3 79890 Hs.72326 219456_s 14 GO:00071 + AW02792 Ras and interactor 3 chr14:929 92980124 93155332 1.008825 7.396224 1.827919 0.247142 3.552248 211327_x NM_000410 | HFE 3077 Hs.23332 211327_x 6 GO:00024 + AF149804 hemochromatosis chr6:2608 26087508 26095469 -0.04946 7.410502 1.138361 0.153614 2.21325 203300_x NM_003916 | AP1S2 8905 Hs.65350 203300_x X GO:00068 - NM_0039 adaptor-related protein chrX:1584 15843929 15873100 -1.13295 7.415343 1.71093 0.230728 3.289143 201998_a NM_003032 | ST6GAL1 6480 Hs.20745 201998_a 3 GO:00064 + AI743792 ST6 beta-galactosamide alpha- chr3:1866 1.87E+08 1.87E+08 -1.51027 7.416166 2.189073 0.295176 4.485764 201444_s NM_005765 | ATP6AP2 10159 Hs.49596 201444_s X GO:00020 + NM_0057 ATPase, H+ transporting, chrX:4044 40440215 40465886 -1.799 7.416329 1.864745 0.251438 3.617807 218149_s NM_018660 | ZNF395 55893 Hs.43553 218149_s 8 GO:00063 - NM_0176 zinc finger protein 395 chr8:2820 28203103 28243977 0.802179 7.422259 3.635048 0.48975 11.64949 220005_a NM_176894 | P2RY13 53829 Hs.54639 220005_a 3 GO:00071 - NM_0239 purinergic receptor P2Y, G- chr3:1510 1.51E+08 1.51E+08 1.115138 7.430235 2.434857 0.327696 5.522134 217770_a NM_015937 | PIGT 51604 Hs.43738 217770_a 20 GO:00162 + NM_0159 phosphatidylinositol glycan chr20:440 44044723 44054884 0.750807 7.43322 1.007135 0.135491 2.004908 217478_s NA NA NA NA 217478_s NA NA NA X76775 NA chrNA:-1-- -1 -1 0.710992 7.441746 2.268898 0.304888 4.690159 202382_s NM_005471 | GNPDA1 10007 Hs.63385 202382_s 5 GO:00059 - NM_0054 glucosamine-6-phosphate chr5:1413 1.41E+08 1.41E+08 -1.37377 7.445107 1.840978 0.247274 3.56056

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 204857_a NM_001013836 MAD1L1 8379 Hs.65483 204857_a 7 GO:00000 - NM_0035 MAD1 mitotic arrest deficient- chr7:1855 1855427 2272583 -0.8577 7.449215 2.306346 0.309609 4.859192 217889_s NM_001127383 CYBRD1 79901 Hs.72315 217889_s 2 GO:00229 + NM_0248 cytochrome b reductase 1 chr2:1723 1.72E+08 1.72E+08 0.76681 7.450325 2.060214 0.276527 4.226532 213405_a NM_020673 | RAB22A 57403 Hs.52904 213405_a 20 GO:00068 + N95443 RAB22A, member RAS chr20:568 56884770 56942560 0.205234 7.451236 1.346783 0.180746 2.553298 204759_a NM_001268 | RCBTB2 1102 Hs.65271 204759_a 13 GO:00055 - NM_0012 regulator of chromosome chr13:490 49063100 49107316 -0.87256 7.451613 2.91392 0.391046 7.161986 203156_a NM_016248 | AKAP11 11215 Hs.10510 203156_a 13 GO:00072 + NM_0162 A kinase (PRKA) anchor protein chr13:428 42846288 42897402 -1.16405 7.453988 3.083864 0.41372 8.015178 214807_a NA NA NA NA 214807_a NA NA NA AI278204 NA chrNA:-1-- -1 -1 0.376815 7.459018 1.711495 0.229453 3.296769 205016_a NM_001099691 TGFA 7039 Hs.17000 205016_a 2 GO:00001 - NM_0032 transforming growth factor, chr2:7067 70674418 70781105 -0.83425 7.463612 2.633713 0.352874 6.469879 212263_a NM_006775 | QKI 9444 Hs.51032 212263_a 6 GO:00015 + AI114716 quaking homolog, KH domain chr6:1638 1.64E+08 1.64E+08 0.063314 7.484227 1.809462 0.24177 3.467496 39729_at NM_005809 | PRDX2 7001 Hs.43212 39729_at 19 GO:00001 - L19185 peroxiredoxin 2 chr19:129 12911426 12912694 2.540916 7.502231 1.673624 0.223084 3.235351 201403_s NM_004528 | MGST3 4259 Hs.19173 201403_s 1 GO:00071 + NM_0045 microsomal glutathione S- chr1:1656 1.66E+08 1.66E+08 -1.82892 7.511766 0.913221 0.121572 1.879113 213652_a NM_006200 | PCSK5 5125 Hs.36854 213652_a 9 GO:00018 + AU15257 proprotein convertase chr9:7850 78505559 78808338 0.235349 7.520095 2.761126 0.367166 6.753257 213733_a NM_012335 | MYO1F 4542 Hs.46581 213733_a 19 GO:00081 - BF740152 myosin IF chr19:858 8585998 8642307 0.245855 7.5215 1.207058 0.160481 2.311979 202973_x NM_001015045 FAM13A 10144 Hs.97270 202973_x 4 NA - NM_0148 family with sequence similarity chr4:8964 89647105 89978323 -1.20724 7.532277 3.043904 0.404115 8.656514 202898_a NM_014654 | SDC3 9672 Hs.15828 202898_a 1 GO:00071 - NM_0146 syndecan 3 chr1:3134 31342312 31381480 -1.22496 7.542574 1.825512 0.242028 3.593225 218671_s NM_016311 | ATPIF1 93974 Hs.59090 218671_s 1 GO:00015 + NM_0163 ATPase inhibitory factor 1 chr1:2856 28562610 28564609 0.878537 7.542838 1.526898 0.20243 2.858425 201056_a NM_004487 | GOLGB1 2804 Hs.21338 201056_a 3 GO:00070 - N53479 golgin B1 chr3:1213 1.21E+08 1.21E+08 -2.14827 7.546528 1.0119 0.134088 2.015713 212323_s NM_015378 | VPS13D 55187 Hs.43938 212323_s 1 GO:00081 + AA52455 13 chr1:1229 12290112 12572096 0.070566 7.556333 0.719547 0.095224 1.645465 202039_a NA NA NA NA 202039_a NA NA NA NM_0047 NA chrNA:-1-- -1 -1 -1.49423 7.556641 1.862759 0.246506 3.654334 205640_a NM_000694 | ALDH3B1 221 Hs.52384 205640_a 11 GO:00060 + NM_0006 aldehyde dehydrogenase 3 chr11:677 67776047 67796741 -0.74827 7.55941 1.397972 0.184931 2.611041 209166_s NM_000528 | MAN2B1 4125 Hs.35676 209166_s 19 GO:00081 - U68567 mannosidase, alpha, class 2B, chr19:127 12757321 12777591 -0.30925 7.56159 0.962943 0.127347 1.944782 202616_s NM_001110792 MECP2 4204 Hs.20071 202616_s X GO:00001 - AI631140 methyl CpG binding protein 2 chrX:1532 1.53E+08 1.53E+08 -1.30161 7.563202 0.723594 0.095673 1.65359 208970_s NM_000374 | UROD 7389 Hs.78601 208970_s 1 GO:00067 + M14016 uroporphyrinogen chr1:4547 45477829 45481341 -0.33273 7.564427 0.8805 0.1164 1.843683 214784_x NM_015171 | XPO6 23214 Hs.46046 214784_x 16 GO:00066 - BE966299 exportin 6 chr16:281 28109315 28223190 0.374047 7.567366 0.749129 0.098995 1.682802 205039_s NM_006060 | IKZF1 10320 Hs.43594 205039_s 7 GO:00017 + NM_0060 IKAROS family zinc finger 1 chr7:5034 50344377 50472796 -0.83066 7.573743 1.115912 0.14734 2.17689 202107_s NM_004526 | MCM2 4171 Hs.47748 202107_s 3 GO:00062 + NM_0045 minichromosome maintenance chr3:1273 1.27E+08 1.27E+08 -1.46869 7.573856 0.786797 0.103883 1.723811 218727_a NM_018231 | SLC38A7 55238 Hs.10499 218727_a 16 GO:00068 - NM_0182 solute carrier family 38, chr16:587 58700297 58718674 0.887402 7.579332 0.943718 0.124512 1.918162 218208_a NM_001146343 PQLC1 80148 Hs.28828 218208_a 18 GO:00160 - NM_0250 PQ loop repeat containing 1 chr18:776 77662419 77711653 0.810262 7.585052 1.130641 0.149062 2.192861 214691_x NM_001040450 FAM63B 54629 Hs.59112 214691_x 15 GO:00081 + AU12143 family with sequence similarity chr15:590 59063392 59149732 0.362438 7.592808 1.018667 0.134162 2.027945 219952_s NM_020533 | MCOLN1 57192 Hs.63185 219952_s 19 GO:00068 + NM_0205 mucolipin 1 chr19:758 7587495 7598894 1.104076 7.597063 2.526698 0.332589 5.644126 208915_s NM_015044 | GGA2 23062 Hs.46033 208915_s 16 GO:00161 - AF190863 golgi-associated, gamma chr16:234 23474863 23521815 -0.33949 7.604296 1.199366 0.157722 2.300764 200000_s NM_006445 | PRPF8 10594 Hs.18136 200000_s 17 GO:00003 - NM_0064 PRP8 pre-mRNA processing chr17:155 1553923 1588176 -5.21687 7.621594 1.043407 0.136901 2.052464 200599_s NM_003299 | HSP90B1 7184 Hs.19237 200599_s 12 GO:00016 + NM_0032 heat shock protein 90kDa beta chr12:104 1.04E+08 1.04E+08 -3.36535 7.632589 1.47449 0.193184 2.774657 212360_a NM_004037 | AMPD2 271 Hs.82927 212360_a 1 GO:00061 + AI916249 adenosine monophosphate chr1:1101 1.1E+08 1.1E+08 0.074996 7.644445 2.108334 0.275799 4.391406 216268_s NM_000214 | JAG1 182 Hs.22401 216268_s 20 GO:00015 - U77914 jagged 1 (Alagille syndrome) chr20:106 10618331 10654694 0.556628 7.660968 2.782472 0.363201 6.892788 207809_s NM_001183 | ATP6AP1 537 Hs.6551 207809_s X GO:00068 + NM_0011 ATPase, H+ transporting, chrX:1536 1.54E+08 1.54E+08 -0.47275 7.678783 0.778572 0.101393 1.714787 212178_s NA NA NA NA 212178_s NA NA NA AK022555 NA chrNA:-1-- -1 -1 0.052557 7.690562 0.596626 0.077579 1.511491 203472_s NM_001145211 SLCO2B1 11309 Hs.7884 203472_s 11 GO:00068 + AB026256 solute carrier organic anion chr11:748 74862039 74917444 -1.09778 7.693152 3.19687 0.415548 9.758569 219329_s NM_001170795 C2orf28 51374 Hs.9527 219329_s 2 GO:00081 + NM_0160 chromosome 2 open reading chr2:2743 27434898 27440044 0.986273 7.714955 1.027275 0.133154 2.044693 214992_s NM_001375 | DNASE2 1777 Hs.11824 214992_s 19 GO:00069 - AD00009 deoxyribonuclease II, lysosomal chr19:129 12986024 12992335 0.399889 7.728182 2.473523 0.320065 5.436352 212826_s NM_001636 | SLC25A6 293 Hs.35092 212826_s X chrY:1505 - AI961224 solute carrier family 25 chrX:1505 1505044 1511039 0.133083 7.733267 1.079322 0.139569 2.107085 201482_a NM_001004128 QSOX1 5768 Hs.51837 201482_a 1 GO:00064 + NM_0028 quiescin Q6 sulfhydryl oxidase 1 chr1:1801 1.8E+08 1.8E+08 -1.77265 7.766224 1.761954 0.226874 3.339475 213626_a NM_032783 | CBR4 84869 Hs.65931 213626_a 4 GO:00551 - AL049442 carbonyl reductase 4 chr4:1699 1.7E+08 1.7E+08 0.232196 7.781156 1.726463 0.221878 3.313166 210184_a NM_000887 | ITGAX 3687 Hs.24847 210184_a 16 GO:00071 + M81695 integrin, alpha X (complement chr16:313 31366508 31394318 -0.18388 7.783991 1.888308 0.242589 3.662717 219289_a NM_182922 | HEATR3 55027 Hs.31391 219289_a 16 GO:00054 + NM_0179 HEAT repeat containing 3 chr16:500 50099880 50139373 0.979253 7.794224 1.269651 0.162896 2.419731 201719_s NM_001135554 EPB41L2 2037 Hs.48647 201719_s 6 GO:00308 - NM_0014 erythrocyte chr6:1311 1.31E+08 1.31E+08 -1.63868 7.796872 1.7938 0.230067 3.500635 222275_a NA NA NA NA 222275_a NA NA NA AI039469 NA chrNA:-1-- -1 -1 2.073469 7.798081 0.784038 0.100542 1.723373

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 208073_x NM_001001894 TTC3 7267 Hs.36821 208073_x 21 GO:00065 + NM_0033 tetratricopeptide repeat chr21:384 38445570 38575406 -0.4412 7.804191 2.225876 0.285215 4.727194 212593_s NM_014456 | PDCD4 27250 Hs.71149 212593_s 10 GO:00069 + N92498 4 chr10:112 1.13E+08 1.13E+08 0.103725 7.83915 1.267513 0.16169 2.404426 222235_s NA NA NA NA 222235_s NA NA NA AL139812 NA chrNA:-1-- -1 -1 2.030869 7.840586 2.444303 0.31175 5.279339 218191_s NM_018368 | LMBRD1 55788 Hs.27164 218191_s 6 GO:00068 - NM_0183 LMBR1 domain containing 1 chr6:7038 70385641 70507049 0.808003 7.850362 0.997053 0.127007 1.998043 204438_a NA NA NA NA 204438_a NA NA NA NM_0024 NA chrNA:-1-- -1 -1 -0.92412 7.852221 5.677388 0.72303 42.5037 212899_a NM_015076 | CDK19 23097 Hs.58486 212899_a 6 GO:00064 - AB028951 cyclin-dependent kinase 19 chr6:1109 1.11E+08 1.11E+08 0.142372 7.855341 2.851425 0.362992 6.892839 204336_s NM_001039467 RGS19 10287 Hs.42233 204336_s 20 GO:00069 - NM_0058 regulator of G-protein signaling chr20:627 62704536 62711324 -0.94057 7.858521 1.428111 0.181728 2.669695 201795_a NM_002296 | LBR 3930 Hs.43516 201795_a 1 GO:00160 - NM_0022 lamin B receptor chr1:2255 2.26E+08 2.26E+08 -1.60028 7.860047 1.741611 0.221578 3.300036 219378_a NM_001110798 NAA16 79612 Hs.51291 219378_a 13 GO:00064 + NM_0245 N(alpha)-acetyltransferase 16, chr13:418 41885340 41932853 0.994861 7.866622 2.068358 0.262928 4.102828 217080_s NM_004839 | HOMER2 9455 Hs.57844 217080_s 15 GO:00072 - Y19026 homer homolog 2 (Drosophila) chr15:835 83517737 83621473 0.659569 7.876936 3.024036 0.38391 8.527389 217740_x NM_000972 | RPL7A 6130 Hs.49983 217740_x 9 GO:00422 + NM_0009 ribosomal protein L7a chr9:1362 1.36E+08 1.36E+08 0.746677 7.89562 0.696073 0.088159 1.619033 38487_at NM_015136 | STAB1 23166 Hs.30198 38487_at 3 GO:00427 + D87433 stabilin 1 chr3:5252 52529355 52558509 2.493276 7.901307 2.229534 0.282173 4.63263 209099_x NM_000214 | JAG1 182 Hs.22401 209099_x 20 GO:00015 - U73936 jagged 1 (Alagille syndrome) chr20:106 10618331 10654694 -0.31715 7.921691 3.016226 0.380755 8.441685 211974_x NM_005349 | RBPJ 3516 Hs.47939 211974_x 4 GO:00017 + AL513759 recombination signal binding chr4:2632 26321331 26433278 0.027033 7.922669 1.287624 0.162524 2.44047 213761_a NM_017440 | MDM1 56890 Hs.65570 213761_a 12 GO:00056 - AW66485 Mdm1 nuclear protein homolog chr12:687 68718786 68726161 0.24919 7.923855 1.385328 0.17483 2.615798 214541_s NM_006775 | QKI 9444 Hs.51032 214541_s 6 GO:00015 + AF142418 quaking homolog, KH domain chr6:1638 1.64E+08 1.64E+08 0.345092 7.930005 1.281349 0.161582 2.418089 206050_s NM_002939 | RNH1 6050 Hs.53068 206050_s 11 GO:00064 - NM_0029 / chr11:494 494511 507273 -0.69297 7.933943 1.073799 0.135342 2.102222 213236_a NM_015278 | SASH1 23328 Hs.19313 213236_a 6 GO:00055 + AK025495 SAM and SH3 domain containing chr6:1486 1.49E+08 1.49E+08 0.18407 7.941483 2.645338 0.333104 6.172852 200623_s NM_005184 | CALM3 808 Hs.51548 200623_s 19 GO:00069 + NM_0051 calmodulin 3 (phosphorylase chr19:471 47104511 47114038 -3.19475 7.942396 1.677941 0.211264 3.241165 203769_s NM_000351 | STS 412 Hs.52257 203769_s X GO:00081 + NM_0003 steroid (microsomal), chrX:7137 7137471 7272680 -1.03869 7.959064 0.685002 0.086066 1.608728 57715_at NM_015916 | CALHM2 51063 Hs.24154 57715_at 10 GO:00160 - W72694 calcium homeostasis modulator chr10:105 1.05E+08 1.05E+08 3.147843 7.966863 1.365629 0.171414 2.592757 211761_s NM_001007214 CACYBP 27101 Hs.50852 211761_s 1 GO:00199 + BC005975 calcyclin binding protein chr1:1749 1.75E+08 1.75E+08 0.002118 7.976668 1.874897 0.235048 3.64541 221472_a NM_006811 | SERINC3 10955 Hs.27216 221472_a 20 GO:00069 - Z97053 incorporator 3 chr20:431 43127900 43150726 1.542288 7.979754 0.986957 0.123683 1.977702 211938_a NM_001417 | EIF4B 1975 Hs.64839 211938_a 12 GO:00064 + BF247371 eukaryotic translation initiation chr12:534 53400061 53435992 0.022522 7.98534 1.548673 0.193939 2.921962 200099_s NM_001006 | RPS3A 6189 Hs.35657 200099_s 4 GO:00064 + AL356115 ribosomal protein S3A chr4:1520 1.52E+08 1.52E+08 -3.4176 8.016233 0.76557 0.095502 1.699499 201278_a NM_001343 | DAB2 1601 Hs.48198 201278_a 5 GO:00009 - N21202 disabled homolog 2, mitogen- chr5:3937 39371779 39425335 -1.92623 8.018673 2.862171 0.356938 7.169166 218458_a NM_178439 | GMCL1 64395 Hs.29397 218458_a 2 GO:00072 + NM_0224 germ cell-less homolog 1 chr2:7005 70056817 70106730 0.846065 8.037864 2.526602 0.314338 5.623538 202120_x NM_004069 | AP2S1 1175 Hs.11959 202120_x 19 GO:00161 - NM_0040 adaptor-related protein chr19:473 47341422 47354203 -1.46407 8.042695 1.002025 0.124588 2.007292 204061_a NM_005044 | PRKX 5613 Hs.39078 204061_a X GO:00064 - NM_0050 protein kinase, X-linked chrX:3522 3522383 3631675 -0.98683 8.053377 1.342588 0.166711 2.517983 203663_s NM_004255 | COX5A 9377 Hs.40190 203663_s 15 GO:00160 - NM_0042 cytochrome c oxidase subunit chr15:752 75212618 75230495 -1.05968 8.055688 0.764354 0.094884 1.696421 211858_x NM_000516 | GNAS 2778 Hs.12589 211858_x 20 GO:00019 + AF088184 GNAS complex locus chr20:574 57414794 57486249 0.013091 8.06518 1.084137 0.134422 2.122193 201944_a NM_000521 | HEXB 3074 Hs.69293 201944_a 5 GO:00015 + NM_0005 B (beta chr5:7398 73980968 74017111 -1.53212 8.066165 2.137587 0.265007 4.305217 218473_s NM_024656 | GLT25D1 79709 Hs.41879 218473_s 19 GO:00091 + NM_0246 glycosyltransferase 25 domain chr19:176 17666510 17693965 0.848347 8.070457 1.962523 0.243174 3.876072 201227_s NM_005004 | NDUFB8 4714 Hs.52321 201227_s 10 GO:00061 - NM_0050 NADH dehydrogenase chr10:102 1.02E+08 1.02E+08 -1.97141 8.088173 0.716725 0.088614 1.643136 206016_a NM_014008 | CCDC22 28952 Hs.24770 206016_a X GO:00081 + NM_0140 coiled-coil domain containing chrX:4909 49091940 49107397 -0.69716 8.094198 2.014803 0.248919 4.080502 205101_a NM_000246 | CIITA 4261 Hs.70199 205101_a 16 GO:00069 + NM_0002 class II, major chr16:109 10971054 11018839 -0.82171 8.096308 2.179987 0.269257 4.642711 217827_s NM_001127889 SPG21 51324 Hs.24245 217827_s 15 GO:00082 - NM_0166 spastic paraplegia 21 chr15:652 65255363 65282251 0.758307 8.097775 1.208104 0.14919 2.316436 201284_s NM_001640 | APEH 327 Hs.51796 201284_s 3 GO:00065 + NM_0016 N-acylaminoacyl-peptide chr3:4971 49711434 49720933 -1.92183 8.102291 0.796411 0.098294 1.736201 201900_s NM_006066 | AKR1A1 10327 Hs.47458 201900_s 1 GO:00060 + NM_0060 aldo-keto reductase family 1, chr1:4601 46016497 46035720 -1.55211 8.102507 0.971643 0.119919 1.960286 214830_a NM_001172702 SLC38A6 145389 Hs.20073 214830_a 14 GO:00068 + AI537540 solute carrier family 38, chr14:614 61447831 61519259 0.379567 8.108252 4.754759 0.58641 23.83979 217719_a NM_016091 | EIF3L 51386 Hs.44685 217719_a 22 GO:00064 + NM_0160 eukaryotic translation initiation chr22:382 38245369 38284637 0.743953 8.136796 1.281392 0.157481 2.426441 203683_s NM_003377 | VEGFB 7423 Hs.78781 203683_s 11 GO:00015 + NM_0033 vascular endothelial growth chr11:640 64002265 64006258 -1.05567 8.138877 1.809767 0.222361 3.487484 207980_s NM_001168388 CITED2 10370 Hs.82071 207980_s 6 GO:00001 - NM_0060 Cbp/p300-interacting chr6:1396 1.4E+08 1.4E+08 -0.4524 8.15089 3.064735 0.376 8.180194 214895_s NM_001110 | ADAM10 102 Hs.57850 214895_s 15 GO:00017 - AU13515 ADAM metallopeptidase chr15:588 58888509 59042177 0.387841 8.159057 2.503878 0.306883 5.550647 202123_s NM_005157 | ABL1 25 Hs.43104 202123_s 9 GO:00001 + NM_0051 c-abl oncogene 1, receptor chr9:1335 1.34E+08 1.34E+08 -1.46331 8.17048 1.389879 0.17011 2.631322 218356_a NM_013393 | FTSJ2 29960 Hs.27987 218356_a 7 GO:00063 - NM_0133 FtsJ homolog 2 (E. coli) chr7:2273 2273927 2281833 0.831125 8.171758 1.415805 0.173256 2.652612 © 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 212498_a NA NA NA NA 212498_a NA NA NA AF056433 NA chrNA:-1-- -1 -1 0.092052 8.173109 1.622084 0.198466 3.085423 207224_s NM_014385 | SIGLEC7 27036 Hs.65539 207224_s 19 GO:00071 + NM_0165 sialic acid binding Ig-like lectin chr19:516 51645557 51656783 -0.54406 8.173431 3.010125 0.368282 8.409138 209329_x NM_138820 | HIGD2A 192286 Hs.53457 209329_x 5 GO:00160 + BC000587 HIG1 hypoxia inducible domain chr5:1758 1.76E+08 1.76E+08 -0.28867 8.176599 0.663823 0.081186 1.584043 213725_x NM_022166 | XYLT1 64131 Hs.22907 213725_x 16 GO:00060 - AI693140 xylosyltransferase I chr16:171 17196182 17564738 0.244799 8.180304 3.730633 0.456051 12.32677 217781_s NM_022473 | ZFP106 64397 Hs.51114 217781_s 15 GO:00082 - NM_0224 zinc finger protein 106 homolog chr15:427 42705021 42749730 0.752164 8.200542 1.797092 0.219143 3.486836 219161_s NM_001040138 CKLF 51192 Hs.15159 219161_s 16 GO:00069 + NM_0169 chemokine-like factor chr16:665 66586465 66600154 0.957226 8.201908 2.236416 0.27267 4.617487 206363_a NM_001031804 MAF 4094 Hs.13485 206363_a 16 GO:00063 - NM_0053 v-maf musculoaponeurotic chr16:796 79627745 79634622 -0.6525 8.215184 3.8831 0.472674 13.46772 203063_a NM_014634 | PPM1F 9647 Hs.11272 203063_a 22 GO:00069 - NM_0146 1F (PP2C chr22:222 22273792 22307217 -1.18659 8.239669 1.464405 0.177726 2.76134 201036_s NM_005327 | HADH 3033 Hs.43828 201036_s 4 GO:00551 + NM_0053 hydroxyacyl-Coenzyme A chr4:1089 1.09E+08 1.09E+08 -2.17452 8.259046 2.900703 0.351215 7.282675 213056_a NM_015123 | FRMD4B 23150 Hs.70967 213056_a 3 GO:00057 - AU14501 FERM domain containing 4B chr3:6921 69219145 69435430 0.161831 8.26082 3.833878 0.464104 13.27881 204031_s NM_001098620 PCBP2 5094 Hs.54627 204031_s 12 GO:00083 + NM_0050 poly(rC) binding protein 2 chr12:538 53845885 53874945 -0.992 8.26139 0.776848 0.094034 1.713871 205885_s NM_000885 | ITGA4 3676 Hs.44095 205885_s 2 GO:00071 + L12002 integrin, alpha 4 (antigen chr2:1823 1.82E+08 1.82E+08 -0.71501 8.272095 2.557501 0.309172 5.973662 201095_a NM_004394 | DAP 1611 Hs.75189 201095_a 5 GO:00069 - NM_0043 death-associated protein chr5:1067 10679342 10761387 -2.10433 8.281618 2.254419 0.27222 4.653783 205559_s NM_006200 | PCSK5 5125 Hs.36854 205559_s 9 GO:00018 + NM_0062 proprotein convertase chr9:7850 78505559 78808338 -0.75918 8.298905 3.205791 0.386291 9.014339 35776_at NM_001001132 ITSN1 6453 Hs.16032 35776_at 21 GO:00069 + AF064243 intersectin 1 (SH3 domain chr21:350 35014783 35210801 2.335329 8.30065 2.476006 0.298291 5.57773 202425_x NM_000944 | PPP3CA 5530 Hs.43551 202425_x 4 GO:00000 - NM_0009 protein phosphatase 3 chr4:1019 1.02E+08 1.02E+08 -1.35997 8.308427 2.040649 0.245612 4.052212 221123_x NM_018660 | ZNF395 55893 Hs.43553 221123_x 8 GO:00063 - NM_0186 zinc finger protein 395 chr8:2820 28203103 28243977 1.40972 8.326178 2.587839 0.310808 5.900363 201529_s NM_002945 | RPA1 6117 Hs.46192 201529_s 17 GO:00512 + NM_0029 replication protein A1, 70kDa chr17:173 1733272 1802848 -1.74439 8.334175 1.520002 0.182382 2.858243 212406_s NM_001104925 PCMTD2 55251 Hs.47331 212406_s 20 GO:00064 + AB028973 protein-L-isoaspartate (D- chr20:628 62887047 62907578 0.081003 8.336601 2.051674 0.246104 4.128466 219126_a NM_018288 | PHF10 55274 Hs.43593 219126_a 6 GO:00454 - NM_0182 PHD finger protein 10 chr6:1701 1.7E+08 1.7E+08 0.951967 8.340536 1.233875 0.147937 2.342957 213969_x NM_000992 | RPL29 6159 Hs.42512 213969_x 3 GO:00064 - BF683426 ribosomal protein L29 chr3:5202 52027644 52029958 0.274685 8.345568 0.869342 0.104168 1.824384 201729_s NM_014680 | KIAA0100 9703 Hs.15176 201729_s 17 GO:00055 - NM_0146 KIAA0100 chr17:269 26941458 26972173 -1.63384 8.362651 1.403485 0.167828 2.634617 200645_a NM_007278 | GABARA 11337 Hs.64742 200645_a 17 GO:00002 - NM_0072 GABA(A) receptor-associated chr17:714 7143739 7145753 -3.07694 8.371792 0.73223 0.087464 1.659685 201487_a NM_001114173 CTSC 1075 Hs.12806 201487_a 11 GO:00065 - NM_0018 cathepsin C chr11:880 88053981 88070941 -1.76971 8.374133 2.152751 0.257072 4.365934 201989_s NM_001310 | CREBL2 1389 Hs.59115 201989_s 12 GO:00071 + AL529409 cAMP responsive element chr12:127 12764830 12798041 -1.51391 8.375093 1.773502 0.211759 3.458385 212828_a NM_003898 | SYNJ2 8871 Hs.43449 212828_a 6 GO:00163 + AA19157 synaptojanin 2 chr6:1584 1.58E+08 1.59E+08 0.133351 8.403497 1.424794 0.169548 2.669006 204425_a NM_001164741 ARHGAP4 393 Hs.70132 204425_a X GO:00070 - NM_0016 Rho GTPase activating protein 4 chrX:1531 1.53E+08 1.53E+08 -0.92632 8.42152 2.096905 0.248994 4.237423 208074_s NM_004069 | AP2S1 1175 Hs.11959 208074_s 19 GO:00161 - NM_0215 adaptor-related protein chr19:473 47341422 47354203 -0.44109 8.424488 1.632411 0.19377 3.124427 213848_a NM_001947 | DUSP7 1849 Hs.59166 213848_a 3 GO:00064 - AI655015 dual specificity phosphatase 7 chr3:5208 52082938 52090461 0.259864 8.43209 2.854049 0.338475 7.070082 203825_a NM_007371 | BRD3 8019 Hs.52247 203825_a 9 GO:00081 - NM_0073 bromodomain containing 3 chr9:1368 1.37E+08 1.37E+08 -1.02822 8.434082 1.832143 0.217231 3.51159 35626_at NM_000199 | SGSH 6448 Hs.31074 35626_at 17 GO:00060 - U30894 N-sulfoglucosamine chr17:781 78183080 78194199 2.329747 8.441122 1.408412 0.166851 2.674368 203548_s NM_000237 | LPL 4023 Hs.18087 203548_s 8 GO:00066 + BF672975 lipoprotein chr8:1979 19796581 19824769 -1.08255 8.44209 2.056848 0.243642 4.216549 204674_a NM_006152 | LRMP 4033 Hs.12492 204674_a 12 GO:00069 + NM_0061 lymphoid-restricted membrane chr12:252 25205240 25261268 -0.88628 8.444399 2.130982 0.252354 4.455534 201779_s NM_007282 | RNF13 11342 Hs.12333 201779_s 3 GO:00056 + AF070558 ring finger protein 13 chr3:1495 1.5E+08 1.5E+08 -1.60917 8.44756 1.594741 0.188781 2.998928 202475_a NM_032635 | TMEM147 10430 Hs.9234 202475_a 19 GO:00160 + NM_0063 transmembrane protein 147 chr19:360 36036544 36038428 -1.34387 8.44784 0.983761 0.116451 1.981059 215519_x NM_015705 | SGSM3 27352 Hs.47491 215519_x 22 GO:00070 + AI081779 small signaling chr22:407 40766594 40806293 0.464654 8.474743 0.523581 0.061781 1.43729 211577_s NM_000618 | IGF1 3479 Hs.16056 211577_s 12 GO:00062 - M37484 insulin-like growth factor 1 chr12:102 1.03E+08 1.03E+08 -0.01977 8.493073 2.483854 0.292456 5.751956 201534_s NM_007106 | UBL3 5412 Hs.14557 201534_s 13 GO:00058 - AF044221 ubiquitin-like 3 chr13:303 30338545 30424820 -1.74118 8.494422 2.028597 0.238815 4.039297 209357_a NM_001168388 CITED2 10370 Hs.82071 209357_a 6 GO:00001 - AF109161 Cbp/p300-interacting chr6:1396 1.4E+08 1.4E+08 -0.28523 8.51094 2.881455 0.338559 7.14059 45572_s_ NM_001001560 GGA1 26088 Hs.49915 45572_s_ 22 GO:00161 + AW00969 golgi-associated, gamma chr22:380 38004480 38014127 2.73115 8.519474 1.335728 0.156785 2.536627 212830_a NM_001080497 MEGF9 1955 Hs.72316 212830_a 9 GO:00081 - W68084 multiple EGF-like-domains 9 chr9:1233 1.23E+08 1.23E+08 0.133591 8.522735 2.367713 0.277811 5.040401 219525_a NM_018242 | SLC47A1 55244 Hs.23205 219525_a 17 GO:00068 + NM_0182 solute carrier family 47, chr17:194 19437166 19482346 1.020773 8.522808 3.60987 0.423554 11.91143 201065_s NA NA NA NA 201065_s NA NA NA NM_0015 NA chrNA:-1-- -1 -1 -2.13629 8.532106 1.189938 0.139466 2.283073 204245_s NM_001098783 RPP14 11102 Hs.44632 204245_s 3 GO:00080 + AW24275 /MRP 14kDa chr3:5829 58291971 58305919 -0.9551 8.537515 1.094514 0.128201 2.139237 218610_s NM_001099455 CPPED1 55313 Hs.46000 218610_s 16 GO:00468 - NM_0183 -like chr16:127 12753656 12897744 0.869048 8.540196 1.507633 0.176534 2.867611 206584_a NM_015364 | LY96 23643 Hs.66076 206584_a 8 GO:00069 + NM_0153 lymphocyte antigen 96 chr8:7490 74903586 74941305 -0.62479 8.545701 2.837894 0.332084 6.860258

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 201903_a NM_003365 | UQCRC1 7384 Hs.11925 201903_a 3 GO:00061 - NM_0033 ubiquinol-cytochrome c chr3:4863 48636431 48647098 -1.55065 8.55152 1.0799 0.126282 2.113637 213061_s NM_173474 | NTAN1 123803 Hs.59204 213061_s 16 GO:00076 - AA64330 N-terminal asparagine amidase chr16:151 15131716 15149833 0.162455 8.556947 2.303104 0.26915 4.836542 210891_s NA NA NA NA 210891_s NA NA NA AF035737 NA chrNA:-1-- -1 -1 -0.09899 8.560772 1.456252 0.170108 2.722227 200613_a NM_001025205 AP2M1 1173 Hs.51846 200613_a 3 GO:00161 + NM_0040 adaptor-related protein chr3:1838 1.84E+08 1.84E+08 -3.2495 8.566695 1.157044 0.135063 2.228401 212953_x NM_004343 | CALR 811 Hs.51516 212953_x 19 GO:00001 + BE251303 calreticulin chr19:130 13049413 13055304 0.149114 8.573648 0.953682 0.111234 1.932939 201104_x NA NA NA NA 201104_x NA NA NA NM_0153 NA chrNA:-1-- -1 -1 -2.09288 8.575229 0.98385 0.114732 1.981826 213041_s NM_001001975 ATP5D 513 Hs.41866 213041_s 19 GO:00061 + BE798517 ATP synthase, H+ transporting, chr19:124 1241748 1244823 0.159913 8.581483 1.496525 0.17439 2.837206 211976_a NA NA NA NA 211976_a NA NA NA AK026168 NA chrNA:-1-- -1 -1 0.027334 8.591382 1.550713 0.180496 2.95024 216733_s NM_001482 | GATM 2628 Hs.75335 216733_s 15 GO:00066 - X86401 glycine amidinotransferase (L- chr15:456 45653323 45670980 0.615661 8.611275 4.290087 0.498194 19.0019 212098_a NA NA NA NA 212098_a NA NA NA AL134724 NA chrNA:-1-- -1 -1 0.042327 8.629076 3.236414 0.375059 9.046486 202593_s NM_016641 | GDE1 51573 Hs.51260 202593_s 16 GO:00060 - NM_0166 glycerophosphodiester chr16:195 19513016 19533450 -1.30832 8.630039 1.774569 0.205627 3.439845 218502_s NM_014112 | TRPS1 7227 Hs.65701 218502_s 8 GO:00015 - NM_0141 trichorhinophalangeal chr8:1164 1.16E+08 1.17E+08 0.852791 8.636716 2.78824 0.322836 6.660519 212663_a NM_015258 | FKBP15 23307 Hs.52235 212663_a 9 GO:00064 - AB014574 FK506 binding protein 15, chr9:1159 1.16E+08 1.16E+08 0.112166 8.649434 1.251344 0.144673 2.372819 201612_a NM_000696 | ALDH9A1 223 Hs.2533 201612_a 1 GO:00421 - NM_0006 aldehyde dehydrogenase 9 chr1:1656 1.66E+08 1.66E+08 -1.69479 8.651706 2.622399 0.303108 6.20171 208913_a NM_015044 | GGA2 23062 Hs.46033 208913_a 16 GO:00161 - AA86856 golgi-associated, gamma chr16:234 23474863 23521815 -0.3398 8.672767 1.583389 0.18257 2.990785 205248_a NM_005128 | DOPEY2 9980 Hs.20457 205248_a 21 GO:00068 + NM_0051 dopey family member 2 chr21:375 37536838 37666571 -0.80138 8.679039 1.532144 0.176534 2.906384 208680_a NM_002574 | PRDX1 5052 Hs.18090 208680_a 1 GO:00003 - L19184 peroxiredoxin 1 chr1:4597 45976707 45987609 -0.36753 8.697396 1.214726 0.139665 2.327762 208703_s NM_001142276 APLP2 334 Hs.37024 208703_s 11 GO:00019 + BG427393 amyloid beta (A4) precursor- chr11:129 1.3E+08 1.3E+08 -0.36494 8.715014 2.096145 0.240521 4.201742 201137_s NM_002121 | HLA- 3115 Hs.48513 201137_s 6 GO:00025 + NM_0021 major histocompatibility chr6:3304 33043759 33054976 -2.05905 8.720871 0.695402 0.07974 1.618751 216125_s NM_005493 | RANBP9 10048 Hs.70818 216125_s 6 GO:00064 - AF064606 binding protein 9 chr6:1362 13621730 13711796 0.539273 8.7253 1.281115 0.146828 2.425084 212922_s NM_020197 | SMYD2 56950 Hs.66170 212922_s 1 GO:00055 + AI809870 SET and MYND domain chr1:2144 2.14E+08 2.15E+08 0.145311 8.744781 1.330902 0.152194 2.52726 209113_s NM_006339 | HMG20B 10362 Hs.40653 209113_s 19 GO:00063 + AF288679 high-mobility group 20B chr19:357 3572942 3579079 -0.31554 8.747854 2.30143 0.263085 4.85496 205105_a NM_002372 | MAN2A1 4124 Hs.43282 205105_a 5 GO:00081 + NM_0023 mannosidase, alpha, class 2A, chr5:1090 1.09E+08 1.09E+08 -0.82116 8.751253 1.203808 0.137558 2.30066 202820_a NM_001621 | AHR 196 Hs.17118 202820_a 7 GO:00069 + NM_0016 aryl hydrocarbon receptor chr7:1733 17338275 17385775 -1.24433 8.766167 1.867208 0.213002 3.658342 217168_s NM_001010989 HERPUD1 9709 Hs.14639 217168_s 16 GO:00069 + AF217990 homocysteine-inducible, chr16:569 56965747 56977793 0.670914 8.772043 1.398537 0.159431 2.629288 209264_s NM_001025234 TSPAN4 7106 Hs.65483 209264_s 11 GO:00064 + AF054841 tetraspanin 4 chr11:842 842823 867116 -0.29671 8.781215 2.543123 0.28961 5.749202 208658_a NM_004911 | PDIA4 9601 Hs.93659 208658_a 7 GO:00454 - BC000425 protein disulfide isomerase chr7:1487 1.49E+08 1.49E+08 -0.37023 8.784127 0.853752 0.097193 1.807229 201368_a NM_006887 | ZFP36L2 678 Hs.50309 201368_a 2 GO:00002 - U07802 zinc finger protein 36, C3H type- chr2:4344 43449541 43453745 -1.85482 8.795793 3.880975 0.441231 14.64775 206206_a NM_005582 | CD180 4064 Hs.87205 206206_a 5 GO:00069 - NM_0055 CD180 molecule chr5:6647 66478103 66492617 -0.67292 8.798977 2.605046 0.296062 6.181645 201953_a NM_006384 | CIB1 10519 Hs.71555 201953_a 15 GO:00069 - NM_0063 calcium and integrin binding 1 chr15:907 90773477 90777279 -1.52856 8.815543 0.927265 0.105185 1.905382 218076_s NM_001006634 ARHGAP1 55114 Hs.37379 218076_s 16 GO:00071 - NM_0180 Rho GTPase activating protein chr16:249 24930713 25026675 0.792168 8.819623 1.105826 0.125383 2.153146 209200_a NM_001131005 MEF2C 4208 Hs.64996 209200_a 5 GO:00069 - AL536517 myocyte enhancer factor 2C chr5:8801 88014057 88199869 -0.30516 8.827349 2.310514 0.261745 4.960807 201911_s NM_001001715 FARP1 10160 Hs.40391 201911_s 13 GO:00350 + NM_0057 FERM, RhoGEF (ARHGEF) and chr13:987 98795433 98897556 -1.54672 8.827565 2.687902 0.30449 6.237722 39817_s_ NM_006443 | C6orf108 10591 Hs.10975 39817_s_ 6 GO:00081 - AF040105 chromosome 6 open reading chr6:4319 43193368 43197211 2.545788 8.82968 1.702571 0.192824 3.290865 201216_a NM_001034025 ERP29 10961 Hs.75841 201216_a 12 GO:00064 + NM_0068 endoplasmic reticulum protein chr12:112 1.12E+08 1.12E+08 -1.98039 8.832471 1.823405 0.206443 3.560449 90610_at NM_002319 | LRCH4 4034 Hs.12574 90610_at 7 GO:00073 - AI654857 leucine-rich repeats and chr7:1001 1E+08 1E+08 3.762158 8.835499 1.097209 0.124182 2.13466 211719_x NM_002026 | FN1 2335 Hs.20371 211719_x 2 GO:00015 - BC005858 fibronectin 1 chr2:2162 2.16E+08 2.16E+08 -0.00259 8.84598 5.126893 0.579573 30.46292 200768_s NM_005911 | MAT2A 4144 Hs.51615 200768_s 2 GO:00065 + BC001686 methionine chr2:8576 85766287 85772401 -2.66578 8.850324 1.727466 0.195187 3.29409 211569_s NM_005327 | HADH 3033 Hs.43828 211569_s 4 GO:00551 + AF001903 hydroxyacyl-Coenzyme A chr4:1089 1.09E+08 1.09E+08 -0.02072 8.85832 1.921949 0.216965 3.793703 214686_a NM_006631 | ZNF266 10781 Hs.65618 214686_a 19 GO:00063 - AA86889 zinc finger protein 266 chr19:952 9523271 9546234 0.361846 8.872184 1.004283 0.113195 2.003391 214770_a NM_002445 | MSR1 4481 Hs.14763 214770_a 8 GO:00068 - AI299239 macrophage scavenger receptor chr8:1599 15996827 16050300 0.372304 8.915706 4.007159 0.449449 15.88224 201535_a NM_007106 | UBL3 5412 Hs.14557 201535_a 13 GO:00058 - NM_0071 ubiquitin-like 3 chr13:303 30338545 30424820 -1.7407 8.923907 2.289447 0.256552 4.789107 221588_x NM_005589 | ALDH6A1 4329 Hs.29397 221588_x 14 GO:00551 - AI640855 aldehyde dehydrogenase 6 chr14:745 74526873 74551196 1.595288 8.933233 1.563257 0.174993 2.971062 201576_s NM_000404 | GLB1 2720 Hs.44303 201576_s 3 GO:00081 - NM_0004 galactosidase, beta 1 chr3:3303 33038099 33138694 -1.71622 8.936679 1.201811 0.134481 2.303392 221726_a NM_000983 | RPL22 6146 Hs.51532 221726_a 1 GO:00064 - BE250348 ribosomal protein L22 chr1:6245 6245080 6259679 1.664729 8.944032 1.345224 0.150405 2.55224 207243_s NA NA NA NA 207243_s NA NA NA NM_0017 NA chrNA:-1-- -1 -1 -0.54158 8.980502 1.499317 0.166952 2.822029 © 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 217078_s NM_007261 | CD300A 11314 Hs.9688 217078_s 17 GO:00071 + AJ010102 CD300a molecule chr17:724 72462521 72480931 0.659298 8.987828 3.141751 0.349556 8.965304 205512_s NM_001130846 AIFM1 9131 Hs.42493 205512_s X GO:00551 - NM_0042 apoptosis-inducing factor, chrX:1292 1.29E+08 1.29E+08 -0.7656 9.02284 2.098641 0.232592 4.351575 218614_a NM_018169 | C12orf35 55196 Hs.44512 218614_a 12 NA + NM_0181 open reading chr12:321 32112352 32146031 0.869655 9.023184 1.166285 0.129254 2.252845 219654_a NM_014241 | PTPLA 9200 Hs.11406 219654_a 10 GO:00071 - NM_0142 protein tyrosine phosphatase- chr10:176 17631959 17659373 1.04512 9.02769 1.230847 0.136341 2.338292 212298_a NM_001024628 NRP1 8829 Hs.13170 212298_a 10 GO:00015 - BE620457 1 chr10:334 33486546 33623833 0.067698 9.031952 4.282891 0.474193 18.49747 218034_a NM_016068 | FIS1 51024 Hs.42396 218034_a 7 GO:00002 - NM_0160 fission 1 (mitochondrial outer chr7:1008 1.01E+08 1.01E+08 0.786545 9.0383 1.181961 0.130773 2.268048 210715_s NM_001166103 SPINT2 10653 Hs.31439 210715_s 19 GO:00069 + AF027205 serine peptidase inhibitor, chr19:387 38755097 38783253 -0.11986 9.056936 2.807159 0.309946 7.045493 207957_s NM_002738 | PRKCB 5579 Hs.46035 207957_s 16 GO:00064 + NM_0027 protein kinase C, beta chr16:238 23847299 24231930 -0.45499 9.057334 2.631773 0.290568 6.057508 201381_x NM_001007214 CACYBP 27101 Hs.50852 201381_x 1 GO:00199 + AF057356 calcyclin binding protein chr1:1749 1.75E+08 1.75E+08 -1.84526 9.058389 1.139646 0.125811 2.200154 206272_a NA NA NA NA 206272_a NA NA NA NM_0065 NA chrNA:-1-- -1 -1 -0.66424 9.071437 2.038645 0.224732 4.116353 212560_a NM_003105 | SORL1 6653 Hs.36859 212560_a 11 GO:00066 + AV72826 sortilin-related receptor, L(DLR chr11:121 1.21E+08 1.22E+08 0.099645 9.080226 3.597298 0.396168 12.69628 201563_a NM_003104 | SORD 6652 Hs.63353 201563_a 15 GO:00060 + L29008 chr15:453 45315340 45367038 -1.72334 9.096854 2.485902 0.273271 5.506696 31874_at NM_006478 | GAS2L1 10634 Hs.32285 31874_at 22 GO:00070 + Y07846 growth arrest-specific 2 like 1 chr22:297 29702996 29708774 2.219198 9.09994 1.49582 0.164377 2.824102 205859_a NM_004271 | LY86 9450 Hs.65313 205859_a 6 GO:00069 + NM_0042 lymphocyte antigen 86 chr6:6588 6588933 6655216 -0.71863 9.105588 2.150888 0.236216 4.392955 204361_s NM_003930 | SKAP2 8935 Hs.20077 204361_s 7 GO:00071 - AB014486 src kinase associated chr7:2670 26706689 26904341 -0.93667 9.109225 1.937708 0.212719 3.779846 204150_a NM_015136 | STAB1 23166 Hs.30198 204150_a 3 GO:00427 + NM_0151 stabilin 1 chr3:5252 52529355 52558509 -0.97118 9.142662 2.494812 0.272876 5.592308 201990_s NM_001310 | CREBL2 1389 Hs.59115 201990_s 12 GO:00071 + NM_0013 cAMP responsive element chr12:127 12764830 12798041 -1.51325 9.161166 2.145183 0.23416 4.411933 205684_s NM_017925 | DENND4 55667 Hs.24959 205684_s 9 GO:00160 + NM_0179 DENN/MADD domain chr9:1929 19290748 19374138 -0.74244 9.17118 2.493117 0.271843 5.51019 201038_s NM_006305 | ANP32A 8125 Hs.45874 201038_s 15 GO:00069 - T67821 acidic (leucine-rich) nuclear chr15:690 69070876 69113261 -2.17208 9.175843 1.957001 0.213277 3.861379 209321_s NM_004036 | ADCY3 109 Hs.46789 209321_s 2 GO:00061 - AF033861 adenylate cyclase 3 chr2:2504 25042040 25142055 -0.28969 9.227909 2.04809 0.221945 4.089656 210756_s NM_024408 | NOTCH2 4853 Hs.48736 210756_s 1 GO:00160 - AF308601 Notch homolog 2 (Drosophila) chr1:1204 1.2E+08 1.21E+08 -0.1146 9.237689 1.126841 0.121983 2.185788 210719_s NM_006339 | HMG20B 10362 Hs.40653 210719_s 19 GO:00063 + BC002552 high-mobility group 20B chr19:357 3572942 3579079 -0.11934 9.239597 2.349809 0.254319 5.054976 204046_a NM_004573 | PLCB2 5330 Hs.35588 204046_a 15 GO:00015 - NM_0045 , beta 2 chr15:405 40580098 40600174 -0.98932 9.242659 1.730026 0.187178 3.333499 217513_a NM_001085423 C17orf60 284021 Hs.63174 217513_a 17 GO:00160 + BG334495 chromosome 17 open reading chr17:624 62461568 62464759 0.715837 9.243884 2.411004 0.260822 5.205067 202369_s NM_012288 | TRAM2 9697 Hs.52018 202369_s 6 GO:00150 - NM_0122 translocation associated chr6:5236 52362201 52441862 -1.37775 9.312487 1.917707 0.205929 3.743775 203760_s NM_001045556 SLA 6503 Hs.75367 203760_s 8 GO:00057 - U44403 Src-like-adaptor chr8:1340 1.34E+08 1.34E+08 -1.04076 9.325844 1.865873 0.200076 3.671917 208944_a NM_001024847 TGFBR2 7048 Hs.60427 208944_a 3 GO:00015 + D50683 transforming growth factor, chr3:3064 30647993 30735631 -0.33608 9.338994 3.435957 0.367915 10.42188 212052_s NM_015043 | TBC1D9B 23061 Hs.15582 212052_s 5 GO:00323 - AB014576 TBC1 domain family, member chr5:1792 1.79E+08 1.79E+08 0.036753 9.348011 1.059229 0.113311 2.085343 220735_s NM_001077203 SENP7 57337 Hs.52955 220735_s 3 GO:00199 - NM_0206 SUMO1/sentrin specific chr3:1010 1.01E+08 1.01E+08 1.289042 9.367106 0.916804 0.097875 1.885467 217773_s NM_002489 | NDUFA4 4697 Hs.50098 217773_s 7 GO:00061 - NM_0024 NADH dehydrogenase chr7:1097 10972814 10979813 0.751085 9.368124 0.876923 0.093607 1.83524 41220_at NM_001113491 SEPT9 10801 Hs.44093 41220_at 17 GO:00070 + AB023208 septin 9 chr17:752 75277491 75496676 2.636862 9.370369 1.444689 0.154176 2.709666 219284_a NM_024610 | HSPBAP1 79663 Hs.29169 219284_a 3 GO:00057 - NM_0246 HSPB (heat shock 27kDa) chr3:1224 1.22E+08 1.23E+08 0.978341 9.391809 2.259553 0.240588 4.829129 202032_s NM_006122 | MAN2A2 4122 Hs.11645 202032_s 15 GO:00081 + NM_0061 mannosidase, alpha, class 2A, chr15:914 91447419 91465814 -1.49688 9.408296 1.61365 0.171514 3.077936 208657_s NM_001113491 SEPT9 10801 Hs.44093 208657_s 17 GO:00070 + AF142408 septin 9 chr17:752 75277491 75496676 -0.37034 9.409385 1.788667 0.190094 3.487969 218642_s NM_001011667 CHCHD7 79145 Hs.43691 218642_s 8 NA + NM_0243 coiled-coil-helix-coiled-coil- chr8:5712 57124314 57131174 0.87377 9.414972 2.297265 0.244001 4.882815 201087_a NM_001080855 PXN 5829 Hs.44633 201087_a 12 GO:00069 - NM_0028 paxillin chr12:120 1.21E+08 1.21E+08 -2.11196 9.421472 1.08488 0.11515 2.119563 204220_a NM_004877 | GMFG 9535 Hs.5210 204220_a 19 GO:00064 - NM_0048 glia maturation factor, gamma chr19:398 39818999 39826726 -0.95938 9.45035 1.866532 0.197509 3.648103 212702_s NM_001003800 BICD2 23299 Hs.43693 212702_s 9 GO:00068 - N45111 bicaudal D homolog 2 chr9:9547 95473644 95527083 0.117313 9.457384 1.414251 0.149539 2.672683 221082_s NM_022477 | NDRG3 57446 Hs.43733 221082_s 20 GO:00072 - NM_0224 NDRG family member 3 chr20:352 35280169 35374481 1.3961 9.459154 1.654525 0.174913 3.125097 204192_a NM_001040031 CD37 951 Hs.16655 204192_a 19 GO:00026 + NM_0017 CD37 molecule chr19:498 49838676 49843859 -0.9641 9.459507 2.498932 0.264171 5.616408 208146_s NM_019029 | CPVL 54504 Hs.23338 208146_s 7 GO:00065 - NM_0313 carboxypeptidase, vitellogenic- chr7:2903 29035248 29186153 -0.43199 9.463876 1.521713 0.160792 2.853495 218081_a NM_001039140 C20orf27 54976 Hs.27442 218081_a 20 NA - NM_0178 chromosome 20 open reading chr20:373 3734157 3748452 0.792843 9.464382 1.237393 0.130742 2.364872 212897_a NM_015076 | CDK19 23097 Hs.58486 212897_a 6 GO:00064 - AI738802 cyclin-dependent kinase 19 chr6:1109 1.11E+08 1.11E+08 0.142081 9.475637 1.449467 0.152968 2.720011 209721_s NM_001039670 IFFO1 25900 Hs.15243 209721_s 12 GO:00058 - BC002857 intermediate filament family chr12:664 6648694 6665229 -0.24064 9.484466 1.418825 0.149595 2.67152 218017_s NM_152419 | HGSNAT 138050 Hs.60038 218017_s 8 GO:00160 + NM_0250 heparan-alpha-glucosaminide N-chr8:4299 42995591 43057969 0.784022 9.507948 1.213976 0.12768 2.317038 202192_s NM_001130831 GAS7 8522 Hs.46221 202192_s 17 GO:00510 - NM_0058 growth arrest-specific 7 chr17:981 9813925 10101868 -1.43668 9.512782 2.516298 0.264518 5.59045 © 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 212441_a NM_001100590 KIAA0232 9778 Hs.79276 212441_a 4 GO:00001 + D86985 KIAA0232 chr4:6784 6784458 6885897 0.085167 9.556498 1.968558 0.205992 3.926208 201043_s NM_006305 | ANP32A 8125 Hs.45874 201043_s 15 GO:00069 - NM_0063 acidic (leucine-rich) nuclear chr15:690 69070876 69113261 -2.16596 9.576496 1.462953 0.152765 2.763939 207722_s NM_017797 | BTBD2 55643 Hs.46554 207722_s 19 GO:00009 - NM_0177 BTB (POZ) domain containing 2 chr19:198 1985446 2015702 -0.4835 9.582336 1.495312 0.156049 2.829843 201528_a NM_002945 | RPA1 6117 Hs.46192 201528_a 17 GO:00512 + BG398414 replication protein A1, 70kDa chr17:173 1733272 1802848 -1.74497 9.584859 1.809362 0.188773 3.469492 203178_a NM_001482 | GATM 2628 Hs.75335 203178_a 15 GO:00066 - NM_0014 glycine amidinotransferase (L- chr15:456 45653323 45670980 -1.15914 9.588276 4.086543 0.426202 17.40395 201541_s NM_006349 | ZNHIT1 10467 Hs.21107 201541_s 7 GO:00055 + NM_0063 zinc finger, HIT type 1 chr7:1008 1.01E+08 1.01E+08 -1.73703 9.590244 0.889513 0.092752 1.852059 214430_a NM_000169 | GLA 2717 Hs.69089 214430_a X GO:00081 - NM_0001 galactosidase, alpha chrX:1006 1.01E+08 1.01E+08 0.331368 9.59652 1.153725 0.120223 2.231632 212326_a NM_015378 | VPS13D 55187 Hs.43938 212326_a 1 GO:00081 + AB007922 vacuolar protein sorting 13 chr1:1229 12290112 12572096 0.070958 9.612261 1.645046 0.17114 3.149522 209479_a NM_015439 | CCDC28A 25901 Hs.41201 209479_a 6 NA + BC000758 coiled-coil domain containing chr6:1390 1.39E+08 1.39E+08 -0.2702 9.623524 2.425396 0.252028 5.467563 208981_a NM_000442 | PECAM1 5175 Hs.51441 208981_a 17 GO:00071 - AA70270 platelet/endothelial cell chr17:623 62399863 62401205 -0.33137 9.631975 2.28541 0.237273 4.856426 212228_s NM_020312 | COQ9 57017 Hs.51363 212228_s 16 GO:00067 + AC004382 coenzyme Q9 homolog (S. chr16:574 57481401 57495178 0.058823 9.637284 1.165001 0.120885 2.245714 201757_a NM_004552 | NDUFS5 4725 Hs.63238 201757_a 1 GO:00061 + NM_0045 NADH dehydrogenase chr1:3949 39492005 39500286 -1.62004 9.677326 1.228355 0.126931 2.338709 203060_s NM_001015880 PAPSS2 9060 Hs.52449 203060_s 10 GO:00001 + AF074331 3'-phosphoadenosine 5'- chr10:894 89419475 89507460 -1.18729 9.707356 1.80721 0.186169 3.47389 213474_a NM_001167961 KCTD7 154881 Hs.54662 213474_a 7 GO:00068 + AI890903 potassium channel chr7:6609 66093867 66108038 0.213633 9.722298 2.283007 0.234822 4.897065 221679_s NM_020676 | ABHD6 57406 Hs.47645 221679_s 3 GO:00160 + AF225418 abhydrolase domain containing chr3:5822 58223258 58280459 1.640202 9.735309 2.093129 0.215004 4.222747 218563_a NM_004542 | NDUFA3 4696 Hs.19826 218563_a 19 GO:00061 + NM_0045 NADH dehydrogenase chr19:546 54606159 54610280 0.86163 9.758913 0.717239 0.073496 1.644411 221253_s NM_001145549 TXNDC5 81567 Hs.15083 221253_s 6 GO:00454 - NM_0308 thioredoxin domain containing chr6:7881 7881753 7911041 1.456886 9.762538 0.983146 0.100706 1.97429 202615_a NM_002072 | GNAQ 2776 Hs.26978 202615_a 9 GO:00015 - BF222895 guanine nucleotide binding chr9:8033 80335199 80646192 -1.30207 9.765923 2.335162 0.239113 5.034012 201051_a NM_006305 | ANP32A 8125 Hs.45874 201051_a 15 GO:00069 - BE560202 acidic (leucine-rich) nuclear chr15:690 69070876 69113261 -2.15324 9.769362 1.922824 0.196822 3.75355 89977_at NM_017888 | ACSM5 54988 Hs.65960 89977_at 16 GO:00081 + AI733019 acyl-CoA synthetase medium- chr16:204 20420855 20452278 3.748512 9.771618 1.253243 0.128253 2.386746 202468_s NM_003798 | CTNNAL1 8727 Hs.58488 202468_s 9 GO:00071 - NM_0037 catenin (cadherin-associated chr9:1117 1.12E+08 1.12E+08 -1.34589 9.777197 3.957803 0.404799 15.57832 218094_s NA NA NA NA 218094_s NA NA NA NM_0184 NA chrNA:-1-- -1 -1 0.794582 9.777615 1.015233 0.103832 2.023307 208808_s NM_001130688 HMGB2 3148 Hs.43495 208808_s 4 GO:00062 - BC000903 high-mobility group box 2 chr4:1742 1.74E+08 1.74E+08 -0.35212 9.79672 2.091529 0.213493 4.265286 219481_a NM_001122835 TTC13 79573 Hs.42478 219481_a 1 GO:00054 - NM_0245 tetratricopeptide repeat chr1:2310 2.31E+08 2.31E+08 1.013474 9.797355 2.316563 0.236448 4.997325 221269_s NM_031286 | SH3BGRL 83442 Hs.10905 221269_s 1 GO:00454 + NM_0312 SH3 domain binding glutamic chr1:2660 26606212 26608012 1.462991 9.80772 1.89059 0.192765 3.666304 212085_a NM_001636 | SLC25A6 293 Hs.35092 212085_a X chrY:1505 - AA91685 solute carrier family 25 chrX:1505 1505044 1511039 0.04079 9.815512 1.351809 0.137722 2.546982 202457_s NM_000944 | PPP3CA 5530 Hs.43551 202457_s 4 GO:00000 - AA91123 protein phosphatase 3 chr4:1019 1.02E+08 1.02E+08 -1.34934 9.826293 2.982574 0.30353 7.722598 202878_s NM_012072 | CD93 22918 Hs.97199 202878_s 20 GO:00069 - NM_0120 CD93 molecule chr20:230 23059993 23066977 -1.22965 9.829476 3.618631 0.368141 12.46969 208704_x NM_001142276 APLP2 334 Hs.37024 208704_x 11 GO:00019 + BC000373 amyloid beta (A4) precursor- chr11:129 1.3E+08 1.3E+08 -0.36477 9.832241 1.83386 0.186515 3.536964 203906_a NM_001134382 IQSEC1 9922 Hs.47550 203906_a 3 GO:00320 - AI652645 IQ motif and Sec7 domain 1 chr3:1293 12938718 13114617 -1.01453 9.835782 1.74963 0.177884 3.36881 201861_s NM_001137550 LRRFIP1 9208 Hs.47177 201861_s 2 GO:00063 + BF965566 leucine rich repeat (in FLII) chr2:2385 2.39E+08 2.39E+08 -1.56897 9.860145 1.772703 0.179785 3.435066 209884_s NM_003615 | SLC4A7 9497 Hs.25007 209884_s 3 GO:00068 - AF047033 solute carrier family 4, sodium chr3:2741 27414214 27498245 -0.22083 9.872469 3.207373 0.324881 9.064741 221210_s NM_030769 | NPL 80896 Hs.49696 221210_s 1 GO:00081 + NM_0307 N-acetylneuraminate pyruvate chr1:1827 1.83E+08 1.83E+08 1.439918 9.907605 3.473813 0.350621 10.61855 212503_s NM_014974 | DIP2C 22982 Hs.43239 212503_s 10 GO:00081 - N22859 DIP2 disco-interacting protein 2 chr10:320 320131 735608 0.092714 9.916373 1.556444 0.156957 2.934049 218323_a NM_001033566 RHOT1 55288 Hs.65532 218323_a 17 GO:00069 + NM_0183 ras homolog gene family, chr17:304 30469472 30552745 0.826188 9.931662 1.835708 0.184834 3.55347 200975_a NM_000310 | PPT1 5538 Hs.3873 200975_a 1 GO:00020 - NM_0003 palmitoyl-protein chr1:4053 40538381 40563142 -2.25565 9.943419 1.931656 0.194265 3.794882 204417_a NM_000153 | GALC 2581 Hs.51343 204417_a 14 GO:00081 - NM_0001 chr14:884 88429657 88459907 -0.92757 9.955115 3.133266 0.314739 8.56347 203284_s NM_001134492 HS2ST1 9653 Hs.48823 203284_s 1 GO:00150 + AW15188 heparan sulfate 2-O- chr1:8738 87380334 87564124 -1.13634 9.959984 4.371078 0.438864 19.92713 204238_s NM_006443 | C6orf108 10591 Hs.10975 204238_s 6 GO:00081 - NM_0064 chromosome 6 open reading chr6:4319 43193368 43197211 -0.95611 9.97551 2.673517 0.268008 6.424012 209555_s NM_000072 | CD36 948 Hs.12094 209555_s 7 GO:00019 + M98399 CD36 molecule chr7:8023 80231503 80303732 -0.26101 9.985405 5.343685 0.53515 36.93223 208626_s NM_006373 | VAT1 10493 Hs.51419 208626_s 17 GO:00551 - BC001913 vesicle amine transport protein chr17:411 41166621 41174459 -0.37415 9.994708 2.145756 0.214689 4.392154 214548_x NM_000516 | GNAS 2778 Hs.12589 214548_x 20 GO:00019 + AF064092 GNAS complex locus chr20:574 57414794 57486249 0.346015 10.04204 0.844578 0.084104 1.795189 213238_a NM_020453 | ATP10D 57205 Hs.43724 213238_a 4 GO:00081 + AI478147 ATPase, class V, type 10D chr4:4748 47487409 47595503 0.184272 10.05171 1.635874 0.162746 3.130081 204916_a NM_005855 | RAMP1 10267 Hs.47178 204916_a 2 GO:00068 + NM_0058 receptor (G protein-coupled) chr2:2387 2.39E+08 2.39E+08 -0.84879 10.05605 2.763808 0.27484 6.950244 35974_at NM_006152 | LRMP 4033 Hs.12492 35974_at 12 GO:00069 + U10485 lymphoid-restricted membrane chr12:252 25205240 25261268 2.33976 10.06445 3.103097 0.308323 8.578194 ©201280_s 2016NM_001343 American | DAB2 Medical1601 Hs.48198 Association.201280_s 5 GO:00009 All rights- NM_0013 reserved.disabled homolog 2, mitogen- chr5:3937 39371779 39425335 -1.92501 10.08846 3.24678 0.321831 9.642612

Downloaded From: https://jamanetwork.com/ on 09/30/2021 202969_a NM_003583 | DYRK2 8445 Hs.17313 202969_a 12 GO:00069 + AI216690 dual-specificity tyrosine-(Y)- chr12:680 68042511 68056443 -1.20811 10.08927 2.607336 0.258427 5.987371 204925_a NM_001031681 CTNS 1497 Hs.18766 204925_a 17 GO:00067 + NM_0049 cystinosis, nephropathic chr17:353 3539761 3566396 -0.84741 10.09026 1.838615 0.182217 3.545171 208873_s NM_005669 | REEP5 7905 Hs.42960 208873_s 5 GO:00081 - BC000232 receptor accessory protein 5 chr5:1122 1.12E+08 1.12E+08 -0.34454 10.12747 2.095545 0.206917 4.22467 203167_a NM_003255 | TIMP2 7077 Hs.63351 203167_a 17 GO:00082 - NM_0032 TIMP metallopeptidase chr17:768 76849062 76921472 -1.16165 10.12902 1.97573 0.195056 3.921651 218306_s NM_003922 | HERC1 8925 Hs.21038 218306_s 15 GO:00199 - NM_0039 hect (homologous to the E6-AP chr15:639 63900817 64126147 0.823935 10.14357 1.829377 0.180349 3.581883 218815_s NM_001136216 TMEM51 55092 Hs.46530 218815_s 1 GO:00160 + NM_0180 transmembrane protein 51 chr1:1547 15479027 15546973 0.901619 10.14744 1.783771 0.175785 3.470618 207540_s NM_001135052 SYK 6850 Hs.37172 207540_s 9 GO:00018 + NM_0031 spleen tyrosine kinase chr9:9356 93564011 93660833 -0.50523 10.15032 1.722684 0.169717 3.278701 217028_a NM_001008540 CXCR4 7852 Hs.59341 217028_a 2 GO:00001 - AJ224869 chemokine (C-X-C motif) chr2:1368 1.37E+08 1.37E+08 0.652875 10.17263 3.997498 0.392966 15.53471 203582_s NM_004578 | RAB4A 5867 Hs.29616 203582_s 1 GO:00072 + NM_0045 RAB4A, member RAS oncogene chr1:2294 2.29E+08 2.29E+08 -1.07592 10.17582 1.080052 0.106139 2.117672 201522_x NA NA NA NA 201522_x NA NA NA NM_0030 NA chrNA:-1-- -1 -1 -1.74869 10.19542 2.557491 0.250847 5.917185 209485_s NM_018030 | OSBPL1A 114876 Hs.37072 209485_s 18 GO:00161 - W19983 oxysterol binding protein-like chr18:217 21742012 21977790 -0.26942 10.1983 2.531401 0.248218 5.733173 209184_s NM_003749 | IRS2 8660 Hs.44234 209184_s 13 GO:00020 - BF700086 substrate 2 chr13:110 1.1E+08 1.1E+08 -0.30706 10.20043 2.315854 0.227035 4.901644 44790_s_ NM_025113 | C13orf18 80183 Hs.98117 44790_s_ 13 NA - AI129310 chromosome 13 open reading chr13:469 46916138 46961635 2.72058 10.2018 1.834185 0.17979 3.566381 220189_s NM_014275 | MGAT4B 11282 Hs.56741 220189_s 5 GO:00059 - NM_0142 mannosyl (alpha-1,3-)- chr5:1792 1.79E+08 1.79E+08 1.153611 10.22677 1.34803 0.131814 2.535801 45288_at NM_020676 | ABHD6 57406 Hs.47645 45288_at 3 GO:00160 + AA20923 abhydrolase domain containing chr3:5822 58223258 58280459 2.724546 10.23747 2.633944 0.257285 6.089905 201064_s NM_001135653 PABPC4 8761 Hs.16990 201064_s 1 GO:00075 - NM_0038 poly(A) binding protein, chr1:4002 40026484 40042521 -2.1379 10.2443 2.152417 0.210109 4.413914 209380_s NM_001023587 ABCC5 10057 Hs.36856 209380_s 3 GO:00324 - AF146074 ATP-binding cassette, sub- chr3:1837 1.84E+08 1.84E+08 -0.2824 10.26587 3.173546 0.309136 8.813205 219452_a NM_022355 | DPEP2 64174 Hs.37263 219452_a 16 GO:00065 - NM_0223 dipeptidase 2 chr16:680 68021294 68033364 1.007905 10.26975 3.845001 0.374401 14.47066 203283_s NM_001134492 HS2ST1 9653 Hs.48823 203283_s 1 GO:00150 + AK023260 heparan sulfate 2-O- chr1:8738 87380334 87564124 -1.13649 10.27257 2.4362 0.237156 5.492225 207132_x NM_002624 | PFDN5 5204 Hs.65532 207132_x 12 GO:00064 + NM_0026 prefoldin subunit 5 chr12:536 53689234 53693232 -0.5551 10.30281 1.568882 0.152277 2.977755 200971_s NM_014445 | SERP1 27230 Hs.51832 200971_s 3 GO:00064 - NM_0144 stress-associated endoplasmic chr3:1502 1.5E+08 1.5E+08 -2.26176 10.3495 1.360077 0.131415 2.561261 36030_at NM_001039670 IFFO1 25900 Hs.15243 36030_at 12 GO:00058 - AL080214 intermediate filament family chr12:664 6648694 6665229 2.343509 10.36865 1.549092 0.149402 2.912746 212157_a NM_002998 | SDC2 6383 Hs.1501 212157_a 8 GO:00081 + BE048514 syndecan 2 chr8:9750 97505881 97624037 0.050112 10.37039 3.477952 0.335373 10.89584 202477_s NM_006659 | TUBGCP2 10844 Hs.52337 202477_s 10 GO:00064 - NM_0066 tubulin, gamma complex chr10:135 1.35E+08 1.35E+08 -1.34314 10.40426 0.992874 0.09543 1.992464 209864_a NM_012083 | FRAT2 23401 Hs.14072 209864_a 10 GO:00160 - AB045118 frequently rearranged in chr10:990 99092253 99094458 -0.22322 10.41431 1.874873 0.180029 3.677288 201339_s NM_001007098 SCP2 6342 Hs.47636 201339_s 1 GO:00081 + NM_0029 sterol carrier protein 2 chr1:5339 53392947 53459902 -1.87633 10.42518 1.443039 0.138419 2.715181 200058_s NM_014014 | SNRNP20 23020 Hs.24611 200058_s 2 GO:00003 - BC001417 small nuclear ribonucleoprotein chr2:9694 96940074 96971297 -3.75356 10.45774 1.133929 0.10843 2.193672 215994_x NM_015043 | TBC1D9B 23061 Hs.15582 215994_x 5 GO:00323 - AK001196 TBC1 domain family, member chr5:1792 1.79E+08 1.79E+08 0.523084 10.49744 0.936292 0.089192 1.914292 215933_s NM_002729 | HHEX 3087 Hs.11865 215933_s 10 GO:00018 + Z21533 hematopoietically expressed chr10:944 94449680 94455406 0.515783 10.49874 3.25484 0.310022 9.704038 211666_x NM_000967 | RPL3 6122 Hs.11959 211666_x 22 GO:00064 - L22453 ribosomal protein L3 chr22:397 39708887 39715670 -0.00845 10.53073 0.835012 0.079293 1.783087 215707_s NM_000311 | PRNP 5621 Hs.47201 215707_s 20 GO:00081 + AV72532 prion protein chr20:466 4666796 4682233 0.48804 10.53618 1.634512 0.155133 3.088816 214467_a NM_003608 | GPR65 8477 Hs.51344 214467_a 14 GO:00069 + NM_0036 G protein-coupled receptor 65 chr14:884 88471495 88478414 0.336221 10.54736 2.342472 0.222091 5.058163 211047_x NM_004069 | AP2S1 1175 Hs.11959 211047_x 19 GO:00161 - BC006337 adaptor-related protein chr19:473 47341422 47354203 -0.08123 10.56762 1.291874 0.122248 2.451363 213828_x NA NA NA NA 213828_x NA NA NA AA47765 NA chrNA:-1-- -1 -1 0.257417 10.57929 1.234226 0.116664 2.351883 219725_a NM_018965 | TREM2 54209 Hs.43529 219725_a 6 GO:00069 - NM_0189 triggering receptor expressed chr6:4112 41126245 41130922 1.05867 10.62799 3.262798 0.307001 9.665915 213264_a NM_001098620 PCBP2 5094 Hs.54627 213264_a 12 GO:00083 + AW02515 poly(rC) binding protein 2 chr12:538 53845885 53874945 0.187572 10.63603 0.916539 0.086173 1.886987 219228_a NM_001079906 ZNF331 55422 Hs.18567 219228_a 19 GO:00063 + NM_0185 zinc finger protein 331 chr19:540 54024176 54083523 0.968583 10.64219 2.165193 0.203454 4.498322 203408_s NM_001131010 SATB1 6304 Hs.51771 203408_s 3 GO:00001 - NM_0029 SATB homeobox 1 chr3:1838 18389265 18480252 -1.11115 10.66597 2.260115 0.2119 4.731555 204143_s NM_001126123 ENOSF1 55556 Hs.36976 204143_s 18 GO:00081 - NM_0175 enolase superfamily member 1 chr18:673 673860 712662 -0.97242 10.67049 2.475486 0.231994 5.548024 218308_a NM_006342 | TACC3 10460 Hs.10401 218308_a 4 GO:00002 + NM_0063 transforming, acidic coiled-coil chr4:1723 1723265 1746895 0.824179 10.70083 1.994424 0.18638 4.001211 217906_a NM_014315 | KLHDC2 23588 Hs.50926 217906_a 14 GO:00056 + NM_0143 kelch domain containing 2 chr14:502 50234786 50249855 0.769158 10.71896 1.795832 0.167538 3.476987 212464_s NM_002026 | FN1 2335 Hs.20371 212464_s 2 GO:00015 - X02761 fibronectin 1 chr2:2162 2.16E+08 2.16E+08 0.087766 10.72919 4.623262 0.430905 22.93737 220753_s NM_015974 | CRYL1 51084 Hs.37070 220753_s 13 GO:00551 - NM_0159 crystallin, lambda 1 chr13:209 20977808 21100012 1.29449 10.73548 2.562963 0.238738 5.862131 201067_a NM_002803 | PSMC2 5701 Hs.43736 201067_a 7 GO:00065 + BF215487 proteasome (prosome, chr7:1029 1.03E+08 1.03E+08 -2.13449 10.75124 1.079737 0.100429 2.115122 211940_x NA NA NA NA 211940_x NA NA NA BE869922 NA chrNA:-1-- -1 -1 0.022743 10.75565 1.3611 0.126547 2.560843 209782_s NM_001352 | DBP 1628 Hs.41448 209782_s 19 GO:00063 - U79283 D site of albumin promoter chr19:491 49133817 49140639 -0.23315 10.76238 1.8201 0.169117 3.526706

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 219892_a NM_001144903 TM6SF1 53346 Hs.51309 219892_a 15 GO:00081 + NM_0230 transmembrane 6 superfamily chr15:837 83776323 83806110 1.092031 10.78131 3.986475 0.369758 15.44473 204082_a NM_001134778 PBX3 5090 Hs.42802 204082_a 9 GO:00063 + NM_0061 pre-B-cell leukemia homeobox chr9:1285 1.29E+08 1.29E+08 -0.98286 10.78208 2.71662 0.251957 6.499888 208664_s NM_001001894 TTC3 7267 Hs.36821 208664_s 21 GO:00065 + AU13171 tetratricopeptide repeat chr21:384 38445570 38575406 -0.36945 10.78518 1.696441 0.157294 3.220454 218142_s NM_016302 | CRBN 51185 Hs.18925 218142_s 3 GO:00065 - NM_0163 cereblon chr3:3191 3191317 3221401 0.801143 10.79713 1.079954 0.100022 2.112081 37384_at NM_014634 | PPM1F 9647 Hs.11272 37384_at 22 GO:00069 - D86995 protein phosphatase 1F (PP2C chr22:222 22273792 22307217 2.414793 10.81399 1.464497 0.135426 2.761236 215489_x NM_001145721 HOMER3 9454 Hs.72020 215489_x 19 GO:00066 - AI871287 homer homolog 3 (Drosophila) chr19:190 19040009 19052041 0.460903 10.83759 1.947026 0.179655 3.848337 202741_a NM_002731 | PRKACB 5567 Hs.48732 202741_a 1 GO:00071 + AA13024 protein kinase, cAMP- chr1:8454 84543744 84670977 -1.2659 10.85867 4.678068 0.430814 24.61821 209269_s NM_001135052 SYK 6850 Hs.37172 209269_s 9 GO:00018 + AW45091 spleen tyrosine kinase chr9:9356 93564011 93660833 -0.29597 10.89855 2.257313 0.20712 4.723906 205462_s NM_002149 | HPCAL1 3241 Hs.58042 205462_s 2 GO:00055 + NM_0021 hippocalcin-like 1 chr2:1044 10443039 10567742 -0.77221 10.95002 2.280191 0.208236 4.856679 202305_s NM_001042548 FEZ2 9637 Hs.25856 202305_s 2 GO:00071 - AI685892 fasciculation and elongation chr2:3677 36779403 36825332 -1.39796 10.99631 1.045697 0.095095 2.064927 201089_a NM_001693 | ATP6V1B 526 Hs.29591 201089_a 8 GO:00068 + NM_0016 ATPase, H+ transporting, chr8:2005 20054703 20079205 -2.1105 11.00523 1.054268 0.095797 2.07523 204039_a NM_004364 | CEBPA 1050 Hs.76171 204039_a 19 GO:00060 - NM_0043 CCAAT/enhancer binding chr19:337 33790841 33793430 -0.99062 11.03286 3.035715 0.275152 8.024848 202208_s NM_005737 | ARL4C 10123 Hs.11155 202208_s 2 GO:00072 - BC001051 ADP-ribosylation factor-like 4C chr2:2354 2.35E+08 2.35E+08 -1.43109 11.05937 3.105353 0.280789 8.436838 222130_s NM_013393 | FTSJ2 29960 Hs.27987 222130_s 7 GO:00063 - AK024635 FtsJ homolog 2 (E. coli) chr7:2273 2273927 2281833 1.935703 11.126 1.564319 0.1406 2.965336 203879_a NM_005026 | PIK3CD 5293 Hs.51845 203879_a 1 GO:00071 + U86453 phosphoinositide-3-kinase, chr1:9711 9711789 9789171 -1.01891 11.13184 2.77046 0.248877 6.922124 218138_a NM_018848 | MKKS 8195 Hs.47211 218138_a 20 GO:00019 - NM_0188 McKusick-Kaufman syndrome chr20:103 10385832 10414866 0.800626 11.14268 1.927878 0.173018 3.834929 203704_s NM_001003698 RREB1 6239 Hs.29824 203704_s 6 GO:00063 + AW11886 ras responsive element binding chr6:7107 7107829 7252212 -1.05142 11.17819 1.674066 0.149762 3.17494 205579_a NM_000861 | HRH1 3269 Hs.1570 205579_a 3 GO:00071 + NM_0008 histamine receptor H1 chr3:1117 11178778 11304938 -0.75625 11.19195 4.757122 0.425048 25.67917 218856_a NM_014452 | TNFRSF2 27242 Hs.44357 218856_a 6 GO:00069 - NM_0166 tumor necrosis factor receptor chr6:4719 47199268 47277680 0.908148 11.19309 2.919421 0.260824 7.691196 217811_a NM_016275 | SELT 51714 Hs.36905 217811_a 3 GO:00015 + NM_0162 selenoprotein T chr3:1503 1.5E+08 1.5E+08 0.756021 11.1948 1.236171 0.110424 2.355435 204362_a NM_003930 | SKAP2 8935 Hs.20077 204362_a 7 GO:00071 - NM_0039 src kinase associated chr7:2670 26706689 26904341 -0.9365 11.27894 1.801297 0.159704 3.461739 206682_a NM_006344 | CLEC10A 10462 Hs.54403 206682_a 17 GO:00068 - NM_0063 C-type lectin domain family 10, chr17:697 6977856 6983600 -0.61241 11.28738 4.979684 0.441173 32.16844 201236_s NM_006763 | BTG2 7832 Hs.51916 201236_s 1 GO:00062 + NM_0067 BTG family, member 2 chr1:2032 2.03E+08 2.03E+08 -1.96228 11.29789 1.465649 0.129728 2.755739 208982_a NM_000442 | PECAM1 5175 Hs.51441 208982_a 17 GO:00071 - AW57450 platelet/endothelial cell chr17:623 62399863 62401205 -0.33129 11.33463 2.497726 0.220362 5.564871 221552_a NM_020676 | ABHD6 57406 Hs.47645 221552_a 3 GO:00160 + BC001698 abhydrolase domain containing chr3:5822 58223258 58280459 1.57825 11.34767 2.195405 0.193468 4.58448 213587_s NM_001100592 ATP6V0E 155066 Hs.69806 213587_s 7 GO:00160 + AI884867 ATPase, H+ transporting V0 chr7:1495 1.5E+08 1.5E+08 0.2272 11.3572 1.527276 0.134476 2.873612 219549_s NM_006054 | RTN3 10313 Hs.47376 219549_s 11 GO:00161 + NM_0060 reticulon 3 chr11:634 63448921 63527340 1.024588 11.36101 2.428369 0.213746 5.357395 203932_a NM_002118 | HLA-DMB 3109 Hs.65442 203932_a 6 GO:00025 - NM_0021 major histocompatibility chr6:3290 32902414 32908817 -1.0098 11.45855 3.237474 0.282538 9.17545 204122_a NM_003332 | TYROBP 7305 Hs.51536 204122_a 19 GO:00069 - NM_0033 TYRO protein tyrosine kinase chr19:363 36395305 36399211 -0.9761 11.46795 1.084114 0.094534 2.118006 219082_a NM_001145815 AMDHD2 51005 Hs.38910 219082_a 16 GO:00059 + NM_0159 amidohydrolase domain chr16:257 2570362 2579731 0.944944 11.47807 1.183023 0.103068 2.268344 210908_s NM_002624 | PFDN5 5204 Hs.65532 210908_s 12 GO:00064 + AB055804 prefoldin subunit 5 chr12:536 53689234 53693232 -0.09781 11.49487 1.551137 0.134942 2.939413 215051_x NM_001623 | AIF1 199 Hs.76364 215051_x 6 GO:00510 + BF213829 allograft inflammatory factor 1 chr6:3158 31582993 31584796 0.406842 11.50545 1.798955 0.156357 3.467938 202742_s NM_002731 | PRKACB 5567 Hs.48732 202742_s 1 GO:00071 + NM_0027 protein kinase, cAMP- chr1:8454 84543744 84670977 -1.26564 11.50822 4.227875 0.367379 19.02066 201909_a NM_001008 | RPS4Y1 6192 Hs.28237 201909_a Y GO:00064 + NM_0010 ribosomal protein S4, Y-linked 1 chrY:2709 2709622 2734995 -1.5474 11.51674 1.381481 0.119954 2.603658 213364_s NM_003099 | SNX1 6642 Hs.18863 213364_s 15 GO:00068 + AI052536 1 chr15:643 64388176 64436431 0.200181 11.5425 2.781395 0.24097 6.856593 213062_a NM_173474 | NTAN1 123803 Hs.59204 213062_a 16 GO:00076 - AA64330 N-terminal asparagine amidase chr16:151 15131716 15149833 0.16262 11.55017 1.843974 0.159649 3.566562 204168_a NM_002413 | MGST2 4258 Hs.81874 204168_a 4 GO:00071 + NM_0024 microsomal glutathione S- chr4:1405 1.41E+08 1.41E+08 -0.96814 11.58789 1.890116 0.163111 3.721518 219694_a NM_019018 | FAM105A 54491 Hs.15508 219694_a 5 NA + NM_0190 family with sequence similarity chr5:1458 14581890 14616285 1.052384 11.58802 3.047602 0.262996 8.109256 221267_s NM_001130111 FAM108A 81926 Hs.46554 221267_s 19 GO:00055 - NM_0312 family with sequence similarity chr19:187 1876975 1885518 1.462281 11.5885 1.219638 0.105246 2.333395 201384_s NM_005899 | NBR1 4077 Hs.27772 201384_s 17 GO:00468 + NM_0058 neighbor of BRCA1 gene 1 chr17:413 41322497 41363706 -1.84294 11.58881 1.681958 0.145136 3.202159 221766_s NM_017633 | FAM46A 55603 Hs.10784 221766_s 6 NA - AW24667 family with sequence similarity chr6:8245 82455447 82462428 1.684938 11.59916 1.624287 0.140035 3.092995 203285_s NM_001134492 HS2ST1 9653 Hs.48823 203285_s 1 GO:00150 + NM_0122 heparan sulfate 2-O- chr1:8738 87380334 87564124 -1.13611 11.60749 3.791047 0.326603 14.04257 212608_s NA NA NA NA 212608_s NA NA NA W85912 NA chrNA:-1-- -1 -1 0.10553 11.68603 1.653769 0.141517 3.147032 203037_s NM_014751 | MTSS1 9788 Hs.33699 203037_s 8 GO:00300 - NM_0147 metastasis suppressor 1 chr8:1255 1.26E+08 1.26E+08 -1.19249 11.6961 1.489728 0.12737 2.808754 203941_a NM_001145159 INTS9 55756 Hs.16239 203941_a 8 GO:00161 - NM_0182 integrator complex subunit 9 chr8:2862 28625175 28747698 -1.0079 11.72346 1.485885 0.126745 2.792055 ©201910_a 2016NM_001001715 American FARP1 Medical10160 Hs.40391 Association.201910_a 13 GO:00350 All+ rightsBF213279 reserved.FERM, RhoGEF (ARHGEF) and chr13:987 98795433 98897556 -1.54712 11.74877 1.780564 0.151553 3.424703

Downloaded From: https://jamanetwork.com/ on 09/30/2021 217990_a NM_001002000 GMPR2 51292 Hs.36885 217990_a 14 GO:00551 + NM_0165 guanosine monophosphate chr14:247 24701647 24708445 0.780458 11.7691 1.436935 0.122094 2.712801 204044_a NM_014298 | QPRT 23475 Hs.51348 204044_a 16 GO:00081 + NM_0142 quinolinate chr16:296 29690440 29709309 -0.9897 11.81856 3.365159 0.284735 10.54986 202499_s NM_006931 | SLC2A3 6515 Hs.41924 202499_s 12 GO:00059 - NM_0069 solute carrier family 2 chr12:807 8071824 8088892 -1.3365 11.83124 1.886322 0.159436 3.720772 201010_s NM_006472 | TXNIP 10628 Hs.53397 201010_s 1 GO:00096 + NM_0064 thioredoxin interacting protein chr1:1454 1.45E+08 1.45E+08 -2.20516 11.83386 2.581436 0.21814 6.022474 213521_a NM_001142370 PTPN18 26469 Hs.51639 213521_a 2 GO:00064 + AW57537 protein tyrosine phosphatase, chr2:1311 1.31E+08 1.31E+08 0.219445 11.89428 1.636898 0.137621 3.106558 36920_at NM_000252 | MTM1 4534 Hs.65505 36920_at X GO:00064 + U46024 1 chrX:1497 1.5E+08 1.5E+08 2.376307 11.95064 1.583135 0.132473 2.98547 204249_s NM_001142315 LMO2 4005 Hs.34560 204249_s 11 GO:00015 - NM_0055 LIM domain only 2 (rhombotin- chr11:338 33880124 33913836 -0.95458 11.97369 3.99182 0.333383 15.40517 204710_s NM_001033518 WIPI2 26100 Hs.12236 204710_s 7 GO:00432 + NM_0160 WD repeat domain, chr7:5229 5229834 5273485 -0.88059 11.98495 0.870204 0.072608 1.828486 204006_s NA NA NA NA 204006_s NA NA NA NM_0005 NA chrNA:-1-- -1 -1 -0.99649 11.98892 3.025001 0.252316 8.133836 201591_s NM_007184 | NISCH 11188 Hs.43529 201591_s 3 GO:00300 + NM_0071 nischarin chr3:5248 52489523 52527087 -1.70709 12.02652 3.074723 0.255662 8.512037 201819_a NM_001082959 SCARB1 949 Hs.70921 201819_a 12 GO:00019 - NM_0055 scavenger receptor class B, chr12:125 1.25E+08 1.25E+08 -1.58856 12.12177 4.172467 0.344213 18.05803 211734_s NM_002001 | FCER1A 2205 Hs.897 211734_s 1 GO:00018 + BC005912 Fc fragment of IgE, high affinity chr1:1592 1.59E+08 1.59E+08 -9.48E-04 12.13234 4.339788 0.357704 20.63345 219165_a NM_021630 | PDLIM2 64236 Hs.63203 219165_a 8 GO:00056 + NM_0216 PDZ and LIM domain 2 chr8:2243 22436642 22451803 0.95803 12.16593 2.932629 0.241053 7.704694 204319_s NM_001005339 RGS10 6001 Hs.50120 204319_s 10 GO:00099 - NM_0029 regulator of G-protein signaling chr10:121 1.21E+08 1.21E+08 -0.94348 12.18724 1.786847 0.146616 3.449615 210136_a NM_001025081 MBP 4155 Hs.55171 210136_a 18 GO:00069 - AW07043 myelin basic protein chr18:747 74724739 74844774 -0.18993 12.19858 4.188131 0.343329 17.83688 203231_s NM_000332 | ATXN1 6310 Hs.43496 203231_s 6 GO:00063 - AW23561 ataxin 1 chr6:1629 16299343 16761721 -1.14757 12.20343 3.131231 0.256586 8.94869 204834_a NM_006682 | FGL2 10875 Hs.52098 204834_a 7 GO:00071 - NM_0066 -like 2 chr7:7682 76822688 76829150 -0.86089 12.26519 5.38618 0.439144 39.0388 213416_a NM_000885 | ITGA4 3676 Hs.44095 213416_a 2 GO:00071 + BG532690 integrin, alpha 4 (antigen chr2:1823 1.82E+08 1.82E+08 0.20654 12.28596 2.907095 0.236619 7.61173 203547_a NM_000616 | CD4 920 Hs.63165 203547_a 12 GO:00018 + U47924 CD4 molecule chr12:689 6898650 6929976 -1.08292 12.30555 2.102425 0.170852 4.297447 210786_s NM_001167681 FLI1 2313 Hs.50428 210786_s 11 GO:00063 + M93255 Friend leukemia virus chr11:128 1.29E+08 1.29E+08 -0.11082 12.30998 2.580152 0.209598 5.923161 201380_a NM_006371 | CRTAP 10491 Hs.51788 201380_a 3 GO:00072 + NM_0063 cartilage associated protein chr3:3315 33155449 33189264 -1.84585 12.31884 1.881243 0.152713 3.679307 217792_a NM_014426 | SNX5 27131 Hs.31689 217792_a 20 GO:00071 - NM_0144 sorting nexin 5 chr20:179 17922245 17949490 0.753538 12.33326 1.940633 0.15735 3.832499 209288_s NM_006449 | CDC42EP 10602 Hs.36957 209288_s 2 GO:00071 - AL136842 CDC42 effector protein (Rho chr2:3787 37870742 37899326 -0.29359 12.33539 3.083471 0.249969 8.593031 208771_s NM_000895 | LTA4H 4048 Hs.52464 208771_s 12 GO:00065 - J02959 leukotriene A4 hydrolase chr12:963 96394610 96429365 -0.35667 12.37161 2.761633 0.223223 6.726491 219431_a NM_024605 | ARHGAP1 79658 Hs.36863 219431_a 4 GO:00070 + NM_0246 Rho GTPase activating protein chr4:1486 1.49E+08 1.49E+08 1.004007 12.44587 1.185137 0.095223 2.272334 214500_a NM_001040158 H2AFY 9555 Hs.42027 214500_a 5 GO:00063 - AF044286 H2A histone family, member Y chr5:1346 1.35E+08 1.35E+08 0.34009 12.46712 2.987763 0.239652 7.982791 204079_a NM_001008566 TPST2 8459 Hs.72318 204079_a 22 GO:00064 - NM_0035 tyrosylprotein sulfotransferase chr22:269 26921715 26986089 -0.98346 12.47196 2.619721 0.210049 6.21698 209065_a NM_006294 | UQCRB 7381 Hs.13125 209065_a 8 GO:00061 - BC005230 ubiquinol-cytochrome c chr8:9723 97239309 97247862 -0.32117 12.49041 1.203079 0.09632 2.301793 213095_x NM_001623 | AIF1 199 Hs.76364 213095_x 6 GO:00510 + AF299327 allograft inflammatory factor 1 chr6:3158 31582993 31584796 0.166751 12.49642 1.904367 0.152393 3.754996 209540_a NM_000618 | IGF1 3479 Hs.16056 209540_a 12 GO:00062 - AU14491 insulin-like growth factor 1 chr12:102 1.03E+08 1.03E+08 -0.2625 12.49834 4.781215 0.382548 28.33731 214085_x NM_006851 | GLIPR1 11010 Hs.20555 214085_x 12 GO:00160 + AI912583 GLI pathogenesis-related 1 chr12:758 75874512 75895715 0.288959 12.51148 3.828733 0.306018 13.81996 204149_s NM_000850 | GSTM4 2948 Hs.34838 204149_s 1 GO:00081 + NM_0008 glutathione S- mu 4 chr1:1101 1.1E+08 1.1E+08 -0.97134 12.58376 1.893326 0.150458 3.707883 208914_a NM_015044 | GGA2 23062 Hs.46033 208914_a 16 GO:00161 - BE646414 golgi-associated, gamma chr16:234 23474863 23521815 -0.33964 12.60771 2.682999 0.212806 6.356929 212159_x NM_012305 | AP2A2 161 Hs.19121 212159_x 11 GO:00068 + AI125280 adaptor-related protein chr11:925 925840 1012239 0.050337 12.63754 3.164998 0.250444 8.813104 212352_s NM_006827 | TMED10 10972 Hs.74137 212352_s 14 GO:00161 - BE780075 transmembrane emp24-like chr14:755 75598170 75643349 0.073958 12.66142 1.499064 0.118396 2.825707 210495_x NM_002026 | FN1 2335 Hs.20371 210495_x 2 GO:00015 - AF130095 fibronectin 1 chr2:2162 2.16E+08 2.16E+08 -0.14682 12.79877 4.548749 0.355405 22.34625 200969_a NM_014445 | SERP1 27230 Hs.51832 200969_a 3 GO:00064 - BG107676 stress-associated endoplasmic chr3:1502 1.5E+08 1.5E+08 -2.26589 12.84572 2.313347 0.180087 4.984928 213566_a NM_005615 | RNASE6 6039 Hs.23262 213566_a 14 GO:00069 + NM_0056 ribonuclease, RNase A family, chr14:212 21249209 21250624 0.224939 12.87975 3.981084 0.309096 15.56374 209066_x NM_006294 | UQCRB 7381 Hs.13125 209066_x 8 GO:00061 - M26700 ubiquinol-cytochrome c chr8:9723 97239309 97247862 -0.32106 12.93819 1.288322 0.099575 2.441023 214875_x NM_001142276 APLP2 334 Hs.37024 214875_x 11 GO:00019 + AW00184 amyloid beta (A4) precursor- chr11:129 1.3E+08 1.3E+08 0.385109 13.01623 1.280188 0.098353 2.429588 204276_a NM_004614 | TK2 7084 Hs.51261 204276_a 16 GO:00062 - BE895437 thymidine kinase 2, chr16:665 66541906 66584315 -0.95063 13.06591 1.823991 0.139599 3.54914 212321_a NM_003901 | SGPL1 8879 Hs.49998 212321_a 10 GO:00015 + AB033078 sphingosine-1-phosphate chr10:725 72575703 72640930 0.070389 13.18847 2.53288 0.192053 5.811558 217984_a NM_003730 | RNASET2 8635 Hs.52998 217984_a 6 GO:00064 - NM_0037 ribonuclease T2 chr6:1673 1.67E+08 1.67E+08 0.779673 13.26547 2.582421 0.194672 6.001708 201432_a NM_001752 | CAT 847 Hs.50230 201432_a 11 GO:00003 + NM_0017 catalase chr11:344 34460471 34493606 -1.80904 13.28188 2.47847 0.186605 5.597586 214501_s NM_001040158 H2AFY 9555 Hs.42027 214501_s 5 GO:00063 - AF044286 H2A histone family, member Y chr5:1346 1.35E+08 1.35E+08 0.340321 13.3184 2.377127 0.178484 5.181429 205127_a NM_000962 | PTGS1 5742 Hs.20197 205127_a 9 GO:00015 + NM_0009 prostaglandin-endoperoxide chr9:1251 1.25E+08 1.25E+08 -0.81823 13.46973 3.901837 0.289674 15.13473 © 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 201506_a NM_000358 | TGFBI 7045 Hs.36939 201506_a 5 GO:00071 + NM_0003 transforming growth factor, chr5:1353 1.35E+08 1.35E+08 -1.75717 13.55057 3.024428 0.223196 8.01564 203799_a NM_014880 | CD302 9936 Hs.13001 203799_a 2 GO:00160 - NM_0148 CD302 molecule chr2:1606 1.61E+08 1.61E+08 -1.03305 13.60093 3.653056 0.268589 12.63792 216442_x NM_002026 | FN1 2335 Hs.20371 216442_x 2 GO:00015 - AK026737 fibronectin 1 chr2:2162 2.16E+08 2.16E+08 0.578468 13.62055 4.7337 0.347541 25.43399 202233_s NM_006004 | UQCRH 7388 Hs.48157 202233_s 1 GO:00061 + NM_0060 ubiquinol-cytochrome c chr1:4676 46769379 46782445 -1.4223 13.6223 1.410348 0.103532 2.657496 213230_a NM_014603 | CDR2L 30850 Hs.78358 213230_a 17 NA + AI422335 cerebellar degeneration- chr17:729 72983726 73001889 0.183372 13.69421 2.878399 0.210191 7.297443 209460_a NM_000663 | ABAT 18 Hs.33676 209460_a 16 GO:00016 + AF237813 4-aminobutyrate chr16:876 8768443 8878431 -0.27243 13.70667 2.747272 0.200433 6.775445 212605_s NA NA NA NA 212605_s NA NA NA AK025759 NA chrNA:-1-- -1 -1 0.105108 13.71943 2.292475 0.167097 4.878697 211495_x NA NA NA NA 211495_x NA NA NA AF114011 NA chrNA:-1-- -1 -1 -0.02993 13.73837 4.099834 0.298422 17.07133 221756_a NM_001135911 PIK3IP1 113791 Hs.26670 221756_a 22 GO:00160 - AL540260 phosphoinositide-3-kinase chr22:316 31677579 31688520 1.679872 13.7573 2.481648 0.180388 5.576008 205249_a NM_000399 | EGR2 1959 Hs.1395 205249_a 10 GO:00063 - NM_0003 early growth response 2 chr10:645 64571759 64578927 -0.80124 13.75896 3.544772 0.257634 11.49302 217983_s NM_003730 | RNASET2 8635 Hs.52998 217983_s 6 GO:00064 - NM_0037 ribonuclease T2 chr6:1673 1.67E+08 1.67E+08 0.779532 13.86944 2.801786 0.202012 6.964071 218019_s NM_003681 | PDXK 8566 Hs.28449 218019_s 21 GO:00082 + NM_0219 pyridoxal (pyridoxine, vitamin chr21:451 45138977 45182187 0.784325 13.92286 1.953867 0.140335 3.864338 205418_a NM_001143783 FES 2242 Hs.7636 205418_a 15 GO:00072 + NM_0020 feline sarcoma oncogene chr15:914 91427664 91439004 -0.7783 13.95425 2.653531 0.190159 6.23613 216092_s NM_012244 | SLC7A8 23428 Hs.59664 216092_s 14 GO:00065 - AL365347 solute carrier family 7 (cationic chr14:235 23594505 23652849 0.535065 13.97899 2.685159 0.192085 6.406426 211922_s NM_001752 | CAT 847 Hs.50230 211922_s 11 GO:00003 + AY028632 catalase chr11:344 34460471 34493606 0.020721 14.08104 2.648942 0.188121 6.267635 205037_a NM_006860 | RABL4 11020 Hs.41517 205037_a 22 GO:00072 - NM_0068 RAB, member of RAS oncogene chr22:371 37154254 37172114 -0.831 14.13349 1.493666 0.105683 2.813071 202263_a NM_016243 | CYB5R1 51706 Hs.33483 202263_a 1 GO:00551 - NM_0162 cytochrome b5 reductase 1 chr1:2029 2.03E+08 2.03E+08 -1.41206 14.13444 2.260292 0.159914 4.804122 207486_x NM_001039936 CHN2 1124 Hs.65461 207486_x 7 GO:00072 + NM_0040 chimerin (chimaerin) 2 chr7:2923 29234120 29553943 -0.51187 14.16872 1.774438 0.125236 3.425952 212158_a NM_002998 | SDC2 6383 Hs.1501 212158_a 8 GO:00081 + AL577322 syndecan 2 chr8:9750 97505881 97624037 0.050219 14.17273 3.045059 0.214853 8.284104 209541_a NM_000618 | IGF1 3479 Hs.16056 209541_a 12 GO:00062 - AI972496 insulin-like growth factor 1 chr12:102 1.03E+08 1.03E+08 -0.26239 14.23729 5.326192 0.374102 41.67682 221698_s NM_022570 | CLEC7A 64581 Hs.14392 221698_s 12 GO:00018 - AF313468 C-type lectin domain family 7, chr12:102 10279923 10282868 1.649174 14.25748 4.329072 0.303635 19.41641 208699_x NM_001064 | TKT 7086 Hs.89643 208699_x 3 GO:00081 - BF696840 transketolase chr3:5325 53259654 53290068 -0.36538 14.25905 2.351426 0.164908 5.082982 203640_a NM_144778 | MBNL2 10150 Hs.65734 203640_a 13 GO:00434 + BE328496 muscleblind-like 2 (Drosophila) chr13:978 97874573 98046372 -1.06446 14.27558 2.383767 0.166982 5.249147 212215_a NM_001042385 PREPL 9581 Hs.44434 212215_a 2 GO:00065 - AB007896 prolyl endopeptidase-like chr2:4454 44544749 44589001 0.057009 14.34508 2.101242 0.146478 4.283709 202990_a NM_001163940 PYGL 5836 Hs.28241 202990_a 14 GO:00059 - NM_0028 phosphorylase, glycogen, liver chr14:513 51371935 51411248 -1.20371 14.38913 3.51407 0.244217 11.24646 208336_s NM_138501 | TECR 9524 Hs.51564 208336_s 19 GO:00551 + NM_0048 trans-2,3-enoyl-CoA reductase chr19:146 14640381 14676791 -0.40936 14.44994 2.763383 0.191238 6.74924 206042_x NA NA NA NA 206042_x NA NA NA NM_0228 NA chrNA:-1-- -1 -1 -0.69385 14.47203 2.50213 0.172894 5.647449 211986_a NM_001620 | AHNAK 79026 Hs.50275 211986_a 11 GO:00073 - BG287862 AHNAK nucleoprotein chr11:622 62283374 62314332 0.028853 14.49395 2.55121 0.176019 5.862257 217118_s NM_001009880 C22orf9 23313 Hs.59220 217118_s 22 GO:00055 - AK025608 chromosome 22 open reading chr22:455 45588122 45636650 0.66415 14.51869 2.838812 0.195528 7.097292 204119_s NM_001123 | ADK 132 Hs.65658 204119_s 10 GO:00061 + U90339 adenosine kinase chr10:759 75910964 76469059 -0.97663 14.52339 2.23486 0.15388 4.69442 210658_s NM_015044 | GGA2 23062 Hs.46033 210658_s 16 GO:00161 - BC000284 golgi-associated, gamma chr16:234 23474863 23521815 -0.12671 14.53461 1.772348 0.12194 3.408959 214735_a NM_001130699 IPCEF1 26034 Hs.14610 214735_a 6 GO:00069 - AW16671 interaction protein for chr6:1544 1.54E+08 1.55E+08 0.368089 14.54519 3.22685 0.22185 9.219377 207604_s NM_003615 | SLC4A7 9497 Hs.25007 207604_s 3 GO:00068 - NM_0036 solute carrier family 4, sodium chr3:2741 27414214 27498245 -0.49724 14.6049 2.606548 0.178471 6.043375 218031_s NM_001085471 FOXN3 1112 Hs.43428 218031_s 14 GO:00000 - NM_0185 forkhead box N3 chr14:896 89622516 90085494 0.786045 14.69891 2.494819 0.169728 5.615703 202944_a NM_000262 | NAGA 4668 Hs.75372 202944_a 22 GO:00081 - NM_0002 N-acetylgalactosaminidase, chr22:424 42454338 42466846 -1.21368 14.74804 2.052608 0.139178 4.13312 202207_a NM_005737 | ARL4C 10123 Hs.11155 202207_a 2 GO:00072 - BG435404 ADP-ribosylation factor-like 4C chr2:2354 2.35E+08 2.35E+08 -1.4316 14.8235 4.858807 0.327777 28.15515 209185_s NM_003749 | IRS2 8660 Hs.44234 209185_s 13 GO:00020 - AF073310 insulin receptor substrate 2 chr13:110 1.1E+08 1.1E+08 -0.30699 14.82818 2.744449 0.185083 6.676415 202948_a NM_000877 | IL1R1 3554 Hs.70198 202948_a 2 GO:00450 + NM_0008 interleukin 1 receptor, type I chr2:1027 1.03E+08 1.03E+08 -1.21237 14.83808 4.239533 0.28572 19.10722 211742_s NM_006495 | EVI2B 2124 Hs.5509 211742_s 17 GO:00160 - BC005926 ecotropic viral integration site chr17:296 29630787 29641130 0 14.86941 5.351661 0.359911 39.27599 208700_s NM_001064 | TKT 7086 Hs.89643 208700_s 3 GO:00081 - L12711 transketolase chr3:5325 53259654 53290068 -0.36525 14.87605 2.423372 0.162904 5.401549 212345_s NM_194071 | CREB3L2 64764 Hs.72322 212345_s 7 GO:00069 - BE675139 cAMP responsive element chr7:1375 1.38E+08 1.38E+08 0.073096 14.88856 3.197576 0.214767 9.075306 215211_a NR_003370 RRN3P1 730092 Hs.31290 215211_a 16 NA - AF054994 RNA polymerase I transcription chr16:218 21807950 21830495 0.426511 14.92639 3.225883 0.216119 9.316136 209901_x NM_001623 | AIF1 199 Hs.76364 209901_x 6 GO:00510 + U19713 allograft inflammatory factor 1 chr6:3158 31582993 31584796 -0.21879 15.03031 1.906915 0.126871 3.762893 200847_s NM_016127 | TMEM66 51669 Hs.52148 200847_s 8 GO:00160 - NM_0161 transmembrane protein 66 chr8:2992 29920631 29940649 -2.47801 15.12826 1.689563 0.111683 3.226379 202838_a NM_000147 | FUCA1 2517 Hs.37085 202838_a 1 GO:00081 - NM_0001 , alpha-L- 1, tissue chr1:2417 24171573 24194859 -1.24006 15.14621 1.403292 0.09265 2.646228 220416_a NM_024837 | ATP8B4 79895 Hs.51131 220416_a 15 GO:00067 - NM_0248 ATPase, class I, type 8B, chr15:501 50150435 50411419 1.206941 15.14861 4.377556 0.288974 20.61683

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 205849_s NM_006294 | UQCRB 7381 Hs.13125 205849_s 8 GO:00061 - NM_0062 ubiquinol-cytochrome c chr8:9723 97239309 97247862 -0.71993 15.1644 1.549334 0.102169 2.931172 202974_a NM_001166460 MPP1 4354 Hs.49698 202974_a X GO:00071 - NM_0024 membrane protein, chrX:1540 1.54E+08 1.54E+08 -1.20712 15.18679 2.919722 0.192254 7.53531 202449_s NM_002957 | RXRA 6256 Hs.59088 202449_s 9 GO:00018 + NM_0029 , alpha chr9:1372 1.37E+08 1.37E+08 -1.3519 15.23947 2.608912 0.171194 6.146806 209500_x NA NA NA NA 209500_x NA NA NA AF114012 NA chrNA:-1-- -1 -1 -0.26755 15.24283 4.004253 0.262698 15.76072 208130_s NM_001061 | TBXAS1 6916 Hs.52075 208130_s 7 GO:00015 + NM_0309 thromboxane A synthase 1 chr7:1394 1.39E+08 1.4E+08 -0.43408 15.32416 3.927021 0.256263 14.87436 213023_a NM_007124 | UTRN 7402 Hs.13313 213023_a 6 GO:00069 + NM_0071 utrophin chr6:1446 1.45E+08 1.45E+08 0.157762 15.35884 1.954393 0.127249 3.864829 219033_a NM_024615 | PARP8 79668 Hs.36958 219033_a 5 GO:00056 + NM_0246 poly (ADP-ribose) polymerase chr5:4996 49962812 50138169 0.936761 15.38781 0.985449 0.064041 1.979758 212239_a NM_181504 | PIK3R1 5295 Hs.13222 212239_a 5 GO:00071 + AI680192 phosphoinositide-3-kinase, chr5:6752 67522461 67597647 0.060341 15.4115 1.914453 0.124222 3.758843 208983_s NM_000442 | PECAM1 5175 Hs.51441 208983_s 17 GO:00071 - M37780 platelet/endothelial cell chr17:623 62399863 62401205 -0.33115 15.452 2.710268 0.175399 6.560505 209263_x NM_001025234 TSPAN4 7106 Hs.65483 209263_x 11 GO:00064 + BC000389 tetraspanin 4 chr11:842 842823 867116 -0.29681 15.5157 1.86846 0.120424 3.649082 212217_a NM_001042385 PREPL 9581 Hs.44434 212217_a 2 GO:00065 - AU15478 prolyl endopeptidase-like chr2:4454 44544749 44589001 0.05723 15.5158 2.27998 0.146946 4.84697 208454_s NM_016134 | PGCP 10404 Hs.15617 208454_s 8 GO:00065 + NM_0161 plasma glutamate chr8:9765 97657498 98155721 -0.39545 15.62629 1.719338 0.110029 3.291614 207186_s NM_004459 | BPTF 2186 Hs.44420 207186_s 17 GO:00001 + NM_0044 bromodomain PHD finger chr17:658 65821779 65980493 -0.54885 15.78898 1.94731 0.123334 3.866615 221059_s NA NA NA NA 221059_s NA NA NA NM_0216 NA chrNA:-1-- -1 -1 1.389418 15.91113 3.810172 0.239466 13.83044 206687_s NM_002831 | PTPN6 5777 Hs.63489 206687_s 12 GO:00069 + NM_0028 protein tyrosine phosphatase, chr12:705 7055739 7070479 -0.61175 16.09295 2.703839 0.168014 6.523169 210004_a NM_002543 | OLR1 4973 Hs.41248 210004_a 12 GO:00071 - AF035776 oxidized low density chr12:103 10310898 10324790 -0.20631 16.1946 3.233514 0.199666 9.502511 202206_a NM_005737 | ARL4C 10123 Hs.11155 202206_a 2 GO:00072 - AW45036 ADP-ribosylation factor-like 4C chr2:2354 2.35E+08 2.35E+08 -1.43195 16.2983 4.926627 0.302279 29.81466 203232_s NM_000332 | ATXN1 6310 Hs.43496 203232_s 6 GO:00063 - NM_0003 ataxin 1 chr6:1629 16299343 16761721 -1.14728 16.52164 3.496178 0.211612 11.34076 218421_a NM_022766 | CERK 64781 Hs.20066 218421_a 22 GO:00066 - NM_0227 ceramide kinase chr22:470 47080307 47134152 0.840839 16.56185 2.493903 0.150581 5.621719 221666_s NM_013258 | PYCARD 29108 Hs.49909 221666_s 16 GO:00071 - BC004470 PYD and CARD domain chr16:312 31212808 31214251 1.633835 16.59984 3.463604 0.208653 10.93512 204774_a NM_001003927 EVI2A 2123 Hs.59119 204774_a 17 GO:00160 - NM_0142 ecotropic viral integration site chr17:296 29643427 29648767 -0.87033 16.60496 5.513319 0.332028 44.0376 209201_x NM_001008540 CXCR4 7852 Hs.59341 209201_x 2 GO:00001 - L01639 chemokine (C-X-C motif) chr2:1368 1.37E+08 1.37E+08 -0.30504 16.60846 3.493319 0.210334 11.17488 210645_s NM_001001894 TTC3 7267 Hs.36821 210645_s 21 GO:00065 + D83077 tetratricopeptide repeat chr21:384 38445570 38575406 -0.12818 16.75445 2.512106 0.149937 5.723035 209078_s NM_012473 | TXN2 25828 Hs.21192 209078_s 22 GO:00016 - AF276920 thioredoxin 2 chr22:368 36863092 36877687 -0.31948 16.79212 1.266919 0.075447 2.406378 207761_s NM_014033 | METTL7A 25840 Hs.65536 207761_s 12 GO:00081 + NM_0140 methyltransferase like 7A chr12:513 51318533 51326299 -0.47863 16.97665 4.088828 0.24085 16.76704 204221_x NM_006851 | GLIPR1 11010 Hs.20555 204221_x 12 GO:00160 + U16307 GLI pathogenesis-related 1 chr12:758 75874512 75895715 -0.95923 17.17921 2.813216 0.163757 6.979299 209298_s NM_001001132 ITSN1 6453 Hs.16032 209298_s 21 GO:00069 + AF114488 intersectin 1 (SH3 domain chr21:350 35014783 35210801 -0.29238 17.2227 3.180867 0.18469 9.030815 201718_s NM_001135554 EPB41L2 2037 Hs.48647 201718_s 6 GO:00308 - BF511685 erythrocyte membrane protein chr6:1311 1.31E+08 1.31E+08 -1.63925 17.2644 1.978313 0.114589 3.9419 201288_a NM_001175 | ARHGDIB 397 Hs.50487 201288_a 12 GO:00300 - NM_0011 Rho GDP dissociation inhibitor chr12:150 15094949 15114562 -1.91934 17.31672 4.087673 0.236054 16.87556 218697_a NM_016453 | NCKIPSD 51517 Hs.65500 218697_a 3 GO:00070 - NM_0164 NCK interacting protein with chr3:4871 48711279 48723334 0.882735 17.45337 1.175477 0.06735 2.258867 202201_a NM_000713 | BLVRB 645 Hs.51578 202201_a 19 GO:00551 - NM_0007 biliverdin reductase B (flavin chr19:409 40953690 40971725 -1.43375 17.5161 2.768093 0.158031 6.77458 201697_s NM_001130823 DNMT1 1786 Hs.20267 201697_s 19 GO:00001 - NM_0013 DNA (cytosine-5-)- chr19:102 10244022 10305755 -1.64953 17.73105 2.456654 0.138551 5.490852 205466_s NM_005114 | HS3ST1 9957 Hs.50734 205466_s 4 GO:00160 - NM_0051 heparan sulfate (glucosamine) 3-chr4:1139 11399988 11430537 -0.77167 17.78146 3.702099 0.2082 13.06719 204222_s NM_006851 | GLIPR1 11010 Hs.20555 204222_s 12 GO:00160 + NM_0068 GLI pathogenesis-related 1 chr12:758 75874512 75895715 -0.95902 17.86987 3.712348 0.207743 13.07068 209499_x NA NA NA NA 209499_x NA NA NA BF448647 NA chrNA:-1-- -1 -1 -0.26763 17.90554 4.39371 0.245383 20.78997 211919_s NM_001008540 CXCR4 7852 Hs.59341 211919_s 2 GO:00001 - AF348491 chemokine (C-X-C motif) chr2:1368 1.37E+08 1.37E+08 0.020382 18.21484 3.32581 0.182588 10.02416 209348_s NM_001031804 MAF 4094 Hs.13485 209348_s 16 GO:00063 - AF055376 v-maf musculoaponeurotic chr16:796 79627745 79634622 -0.28627 18.55401 5.501405 0.296508 46.16939 211779_x NM_012305 | AP2A2 161 Hs.19121 211779_x 11 GO:00068 + BC006155 adaptor-related protein chr11:925 925840 1012239 0.003998 18.68048 3.136161 0.167884 8.809433 221488_s NM_001014433 CUTA 51596 Hs.52007 221488_s 6 GO:00081 - AF230924 cutA divalent cation tolerance chr6:3338 33384318 33386065 1.549362 18.81768 1.69461 0.090054 3.238583 204458_a NM_012320 | PLA2G15 23659 Hs.63219 204458_a 16 GO:00066 + AL110209 , group XV chr16:682 68279246 68294959 -0.92116 18.83546 2.372057 0.125936 5.176374 202968_s NM_003583 | DYRK2 8445 Hs.17313 202968_s 12 GO:00069 + Y09216 dual-specificity tyrosine-(Y)- chr12:680 68042511 68056443 -1.20838 18.96666 2.121456 0.111852 4.351071 219947_a NM_016184 | CLEC4A 50856 Hs.50465 219947_a 12 GO:00071 + NM_0161 C-type lectin domain family 4, chr12:827 8276227 8291203 1.10293 19.06505 6.534471 0.342746 95.89852 205580_s NM_000861 | HRH1 3269 Hs.1570 205580_s 3 GO:00071 + D28481 histamine receptor H1 chr3:1117 11178778 11304938 -0.75617 19.34807 3.385778 0.174993 10.51289 201743_a NM_000591 | CD14 929 Hs.16386 201743_a 5 GO:00069 - NM_0005 CD14 molecule chr5:1400 1.4E+08 1.4E+08 -1.62639 19.61793 4.058808 0.206893 16.55786 ©204787_a 2016NM_001100431 American VSIG4 Medical11326 Hs.8904 Association.204787_a X GO:00069 All- rightsNM_0072 reserved.V-set and immunoglobulin chrX:6524 65241579 65259967 -0.86816 19.75366 2.322069 0.117551 5.010054 203305_a NM_000129 | F13A1 2162 Hs.33551 203305_a 6 GO:00075 - NM_0001 coagulation factor XIII, A1 chr6:6144 6144311 6320924 -1.13185 19.8497 5.961383 0.300326 61.32518

Downloaded From: https://jamanetwork.com/ on 09/30/2021 213022_s NM_007124 | UTRN 7402 Hs.13313 213022_s 6 GO:00069 + NM_0071 utrophin chr6:1446 1.45E+08 1.45E+08 0.157648 20.15592 2.754134 0.136641 6.76449 36566_at NM_001031681 CTNS 1497 Hs.18766 36566_at 17 GO:00067 + AJ222967 cystinosis, nephropathic chr17:353 3539761 3566396 2.361237 20.17023 1.915392 0.094961 3.773371 204552_a NM_001134224 INPP4A 3631 Hs.46938 204552_a 2 GO:00071 + AA35517 inositol polyphosphate-4- chr2:9906 99061320 99198284 -0.9059 20.29281 2.92632 0.144205 7.579807 202096_s NM_000714 | TSPO 706 Hs.202 202096_s 22 GO:00069 + NM_0007 translocator protein (18kDa) chr22:435 43547534 43559247 -1.47265 20.45821 1.297511 0.063423 2.457626 202429_s NM_000944 | PPP3CA 5530 Hs.43551 202429_s 4 GO:00000 - AL353950 protein phosphatase 3 chr4:1019 1.02E+08 1.02E+08 -1.3583 20.7403 3.498523 0.168682 11.27056 212655_a NM_015144 | ZCCHC14 23174 Hs.15623 212655_a 16 GO:00071 - AB011151 zinc finger, CCHC domain chr16:874 87439851 87525460 0.111065 20.8948 3.033896 0.145199 8.150714 212161_a NM_012305 | AP2A2 161 Hs.19121 212161_a 11 GO:00068 + AA99466 adaptor-related protein chr11:925 925840 1012239 0.050539 21.16064 2.750035 0.12996 6.709167 211732_x NM_001024074 HNMT 3176 Hs.42151 211732_x 2 GO:00075 + BC005907 histamine N-methyltransferase chr2:1387 1.39E+08 1.39E+08 -0.00119 21.22117 2.42651 0.114344 5.385285 202139_a NM_003689 | AKR7A2 8574 Hs.57188 202139_a 1 GO:00059 - NM_0036 aldo-keto reductase family 7, chr1:1963 19630458 19638640 -1.45729 21.45016 1.846664 0.086091 3.595527 205128_x NM_000962 | PTGS1 5742 Hs.20197 205128_x 9 GO:00015 + NM_0009 prostaglandin-endoperoxide chr9:1251 1.25E+08 1.25E+08 -0.81811 21.90001 4.104169 0.187405 17.21446 209459_s NM_000663 | ABAT 18 Hs.33676 209459_s 16 GO:00016 + AF237813 4-aminobutyrate chr16:876 8768443 8878431 -0.2726 22.42586 3.341065 0.148983 10.17663 215764_x NM_012305 | AP2A2 161 Hs.19121 215764_x 11 GO:00068 + AA87764 adaptor-related protein chr11:925 925840 1012239 0.494849 22.83904 3.310331 0.144942 9.92398 218589_a NM_001162497 LPAR6 10161 Hs.12346 218589_a 13 GO:00071 - NM_0057 lysophosphatidic acid receptor chr13:489 48985183 49018840 0.865811 22.84919 3.199372 0.140021 9.203972 202943_s NM_000262 | NAGA 4668 Hs.75372 202943_s 22 GO:00081 - M38083 N-acetylgalactosaminidase, chr22:424 42454338 42466846 -1.21391 22.91422 1.85399 0.08091 3.614615 219666_a NM_022349 | MS4A6A 64231 Hs.52370 219666_a 11 GO:00160 - NM_0223 membrane-spanning 4- chr11:599 59939972 59950674 1.047317 23.04906 5.044694 0.218868 32.67337 203473_a NM_001145211 SLCO2B1 11309 Hs.7884 203473_a 11 GO:00068 + NM_0072 solute carrier organic anion chr11:748 74862039 74917444 -1.09756 23.37597 3.540598 0.151463 11.68955 204236_a NM_001167681 FLI1 2313 Hs.50428 204236_a 11 GO:00063 + NM_0020 Friend leukemia virus chr11:128 1.29E+08 1.29E+08 -0.95646 23.68903 3.074031 0.129766 8.415025 206637_a NM_001081455 P2RY14 9934 Hs.2465 206637_a 3 GO:00071 - NM_0148 purinergic receptor P2Y, G- chr3:1509 1.51E+08 1.51E+08 -0.6182 23.69273 4.65617 0.196523 25.22005 212154_a NM_002998 | SDC2 6383 Hs.1501 212154_a 8 GO:00081 + AI380298 syndecan 2 chr8:9750 97505881 97624037 0.049801 23.75691 3.576289 0.150537 11.91816 206407_s NM_005408 | CCL13 6357 Hs.41462 206407_s 17 GO:00071 + NM_0054 chemokine (C-C motif) ligand 13 chr17:326 32683470 32685628 -0.64706 23.98179 5.242221 0.218592 37.57775 217865_a NM_018434 | RNF130 55819 Hs.48436 217865_a 5 GO:00069 - NM_0184 ring finger protein 130 chr5:1793 1.79E+08 1.79E+08 0.763475 24.10041 2.271417 0.094248 4.829868 207168_s NM_001040158 H2AFY 9555 Hs.42027 207168_s 5 GO:00063 - NM_0048 H2A histone family, member Y chr5:1346 1.35E+08 1.35E+08 -0.55086 24.62613 1.892892 0.076865 3.712586 221724_s NM_016184 | CLEC4A 50856 Hs.50465 221724_s 12 GO:00071 + AF200738 C-type lectin domain family 4, chr12:827 8276227 8291203 1.663146 24.68297 6.330978 0.256492 81.95097 207277_a NM_001144893 CD209 30835 Hs.27869 207277_a 19 GO:00071 - AF290886 CD209 molecule chr19:780 7804880 7812464 -0.53731 25.39895 4.740452 0.18664 26.50572 200903_s NM_000687 | AHCY 191 Hs.38800 200903_s 20 GO:00081 - NM_0006 adenosylhomocysteinase chr20:328 32868072 32899608 -2.36884 26.04123 3.453842 0.13263 10.95659 214719_a NM_001135919 SLC46A3 283537 Hs.11716 214719_a 13 GO:00550 - AK026720 solute carrier family 46, chr13:292 29274219 29293150 0.365992 26.42707 4.444179 0.168168 21.78923 218718_a NM_016205 | PDGFC 56034 Hs.57085 218718_a 4 GO:00071 - NM_0162 platelet derived growth factor C chr4:1576 1.58E+08 1.58E+08 0.886157 26.80241 6.266572 0.233806 76.01349 210166_a NM_003268 | TLR5 7100 Hs.60454 210166_a 1 GO:00071 - AF051151 toll-like receptor 5 chr1:2232 2.23E+08 2.23E+08 -0.18619 27.82271 3.589419 0.12901 12.05155 215813_s NM_000962 | PTGS1 5742 Hs.20197 215813_s 9 GO:00015 + S36219 prostaglandin-endoperoxide chr9:1251 1.25E+08 1.25E+08 0.500518 28.5179 4.774651 0.167426 27.19067 210314_x NM_003808 | TNFSF13 8741 Hs.54673 210314_x 17 GO:00071 + AF114013 tumor necrosis factor (ligand) chr17:746 7461608 7464925 -0.16828 30.05503 4.321945 0.143801 19.98092 205423_a NM_001127 | AP1B1 162 Hs.36879 205423_a 22 GO:00068 - NM_0011 adaptor-related protein chr22:297 29723670 29784572 -0.77764 31.12999 2.053904 0.065978 4.151233 217838_s NM_016337 | EVL 51466 Hs.12586 217838_s 14 GO:00071 + NM_0163 Enah/Vasp-like chr14:100 1.01E+08 1.01E+08 0.759844 32.00537 3.720429 0.116244 13.198 217979_a NM_014399 | TSPAN13 27075 Hs.36454 217979_a 7 GO:00160 + NM_0143 tetraspanin 13 chr7:1679 16793350 16824159 0.779111 -46.7556 -4.36629 0.093385 0.04848 207375_s NM_002189 | IL15RA 3601 Hs.52411 207375_s 10 GO:00071 - NM_0021 interleukin 15 receptor, alpha chr10:599 5994334 6020142 -0.52569 -40.2193 -4.00717 0.099633 0.062143 205599_a NM_005658 | TRAF1 7185 Hs.53125 205599_a 9 GO:00071 - NM_0056 TNF receptor-associated factor chr9:1236 1.24E+08 1.24E+08 -0.75367 -39.7818 -5.1503 0.129464 0.028212 210163_a NM_005409 | CXCL11 6373 Hs.63259 210163_a 4 GO:00071 - AF030514 chemokine (C-X-C motif) ligand chr4:7695 76954841 76957233 -0.18655 -35.549 -8.37673 0.235639 0.002998 204698_a NM_002201 | ISG20 3669 Hs.45926 204698_a 15 GO:00007 + NM_0022 interferon stimulated chr15:891 89182038 89198879 -0.88248 -31.8233 -5.98902 0.188196 0.015807 33304_at NM_002201 | ISG20 3669 Hs.45926 33304_at 15 GO:00007 + U88964 interferon stimulated chr15:891 89182038 89198879 2.25887 -30.4436 -5.7832 0.189965 0.018296 211122_s NM_005409 | CXCL11 6373 Hs.63259 211122_s 4 GO:00071 - AF002985 chemokine (C-X-C motif) ligand chr4:7695 76954841 76957233 -0.07182 -28.594 -7.73065 0.270359 0.004735 209457_a NM_004419 | DUSP5 1847 Hs.2128 209457_a 10 GO:00064 + U16996 dual specificity phosphatase 5 chr10:112 1.12E+08 1.12E+08 -0.27282 -28.495 -4.56541 0.160218 0.042361 210029_a NM_002164 | IDO1 3620 Hs.840 210029_a 8 GO:00025 + M34455 indoleamine 2,3-dioxygenase 1 chr8:3977 39771327 39785945 -0.20321 -28.1972 -6.88838 0.244293 0.008566 35150_at NM_001250 | CD40 958 Hs.47286 35150_at 20 GO:00027 + X60592 CD40 molecule, TNF receptor chr20:447 44746905 44758384 2.318612 -25.2516 -2.91851 0.115577 0.13194 206337_a NM_001838 | CCR7 1236 Hs.37003 206337_a 17 GO:00071 - NM_0018 chemokine (C-C motif) receptor chr17:387 38710022 38721724 -0.65596 -25.2133 -6.73842 0.267256 0.009436 211269_s NM_000417 | IL2RA 3559 Hs.23136 211269_s 10 GO:00024 - K03122 interleukin 2 receptor, alpha chr10:605 6052656 6104333 -0.05484 -24.8229 -4.48235 0.180573 0.044511 205676_a NM_000785 | CYP27B1 1594 Hs.52452 205676_a 12 GO:00551 - NM_0007 cytochrome P450, family 27, chr12:581 58156116 58160976 -0.74357 -23.7096 -5.49658 0.231829 0.022114 ©206513_a 2016NM_004833 American | AIM2 Medical9447 Hs.28189 Association.206513_a 1 GO:00069 All- rightsNM_0048 reserved.absent in melanoma 2 chr1:1590 1.59E+08 1.59E+08 -0.63401 -23.6741 -5.02734 0.212356 0.030516

Downloaded From: https://jamanetwork.com/ on 09/30/2021 209417_s NM_005533 | IFI35 3430 Hs.63225 209417_s 17 GO:00096 + BC001356 interferon-induced protein 35 chr17:411 41158768 41166475 -0.27798 -23.004 -3.15205 0.137022 0.112896 213797_a NM_080657 | RSAD2 91543 Hs.17518 213797_a 2 GO:00302 + AI337069 radical S-adenosyl methionine chr2:7017 7017795 7038363 0.25391 -22.7434 -5.39254 0.237103 0.02366 204533_a NM_001565 | CXCL10 3627 Hs.63258 204533_a 4 GO:00069 - NM_0015 chemokine (C-X-C motif) ligand chr4:7694 76942272 76944650 -0.90886 -22.2124 -5.87245 0.264377 0.017052 218445_a NM_018649 | H2AFY2 55506 Hs.49995 218445_a 10 GO:00063 + NM_0186 H2A histone family, member Y2 chr10:718 71812356 71872039 0.844184 -22.1549 -2.76433 0.124773 0.147625 205890_s NA NA NA NA 205890_s NA NA NA NM_0063 NA chrNA:-1-- -1 -1 -0.71436 -21.9856 -6.78434 0.308581 0.009229 202759_s NA NA NA NA 202759_s NA NA NA BE879367 NA chrNA:-1-- -1 -1 -1.26102 -21.771 -3.74222 0.17189 0.074622 204972_a NM_001032731 OAS2 4939 Hs.41433 204972_a 12 GO:00061 + NM_0168 2'-5'-oligoadenylate synthetase chr12:113 1.13E+08 1.13E+08 -0.84075 -21.5518 -2.86635 0.132998 0.13706 207901_a NM_002187 | IL12B 3593 Hs.674 207901_a 5 GO:00023 - NM_0021 interleukin 12B (natural killer chr5:1587 1.59E+08 1.59E+08 -0.46131 -20.8866 -3.35074 0.160425 0.098703 208992_s NM_003150 | STAT3 6774 Hs.46305 208992_s 17 GO:00001 - BC000627 signal transducer and activator chr17:404 40465342 40540513 -0.32987 -20.7205 -2.17701 0.105065 0.221236 200644_a NM_023009 | MARCKSL 65108 Hs.75061 200644_a 1 GO:00161 - NM_0230 MARCKS-like 1 chr1:3279 32799440 32801834 -3.08114 -19.4302 -3.67107 0.188936 0.077955 221680_s NM_016135 | ETV7 51513 Hs.27239 221680_s 6 GO:00063 - AF147782 ets variant 7 chr6:3633 36333971 36355467 1.640568 -19.2515 -2.31062 0.120023 0.201943 202270_a NM_002053 | GBP1 2633 Hs.62661 202270_a 1 GO:00058 - NM_0020 guanylate binding protein 1, chr1:8951 89517986 89531043 -1.40972 -19.193 -5.79314 0.301836 0.018252 208991_a NM_003150 | STAT3 6774 Hs.46305 208991_a 17 GO:00001 - AA63427 signal transducer and activator chr17:404 40465342 40540513 -0.32996 -18.6836 -1.8702 0.100099 0.273942 205226_a NM_006207 | PDGFRL 5157 Hs.45857 205226_a 8 GO:00081 + NM_0062 platelet-derived growth factor chr8:1743 17434700 17500623 -0.80437 -18.6265 -4.31931 0.231891 0.050816 204747_a NM_001031683 IFIT3 3437 Hs.71433 204747_a 10 GO:00081 + NM_0015 interferon-induced protein chr10:910 91087601 91100724 -0.87449 -18.5623 -3.98338 0.214596 0.062932 209209_s NM_001134999 FERMT2 10979 Hs.50934 209209_s 14 GO:00300 - AW46957 fermitin family homolog 2 chr14:533 53326206 53417815 -0.30416 -18.5041 -3.66543 0.198087 0.07817 208092_s NM_030797 | FAM49A 81553 Hs.46776 208092_s 2 GO:00056 - NM_0307 family with sequence similarity chr2:1673 16730731 16847134 -0.43878 -18.4832 -2.28327 0.123533 0.205658 210511_s NM_002192 | INHBA 3624 Hs.58334 210511_s 7 GO:00000 - M13436 inhibin, beta A chr7:4172 41728602 41742706 -0.14491 -18.1197 -2.4156 0.133314 0.187361 210797_s NM_003733 | OASL 8638 Hs.11863 210797_s 12 GO:00069 - AF063612 2'-5'-oligoadenylate synthetase- chr12:121 1.21E+08 1.21E+08 -0.10941 -17.8376 -3.78388 0.212129 0.072284 210663_s NM_001032998 KYNU 8942 Hs.47012 210663_s 2 GO:00081 + BC000879 kynureninase (L-kynurenine chr2:1436 1.44E+08 1.44E+08 -0.12602 -17.8194 -2.02913 0.113872 0.244471 205660_a NM_003733 | OASL 8638 Hs.11863 205660_a 12 GO:00069 - NM_0037 2'-5'-oligoadenylate synthetase- chr12:121 1.21E+08 1.21E+08 -0.74563 -17.7054 -3.82945 0.216287 0.06979 203773_x NM_000712 | BLVRA 644 Hs.48814 203773_x 7 GO:00551 + NM_0007 biliverdin reductase A chr7:4379 43798271 43846936 -1.03789 -17.6164 -1.35187 0.07674 0.391824 211302_s NM_001037339 PDE4B 5142 Hs.19807 211302_s 1 GO:00071 + L20966 phosphodiesterase 4B, cAMP- chr1:6625 66258192 66840261 -0.05196 -17.4078 -4.59234 0.263809 0.042329 207847_s NM_001018016 MUC1 4582 Hs.89603 207847_s 1 GO:00075 - NM_0024 mucin 1, cell surface associated chr1:1551 1.55E+08 1.55E+08 -0.46803 -17.0613 -3.51805 0.206201 0.086237 200999_s NM_006825 | CKAP4 10970 Hs.74368 200999_s 12 GO:00160 - NM_0068 cytoskeleton-associated chr12:106 1.07E+08 1.07E+08 -2.22089 -17.053 -3.21256 0.188387 0.108868 206157_a NM_002852 | PTX3 5806 Hs.59128 206157_a 3 GO:00018 + NM_0028 pentraxin-related gene, rapidly chr3:1571 1.57E+08 1.57E+08 -0.67922 -17.0198 -4.89811 0.287789 0.032978 202269_x NM_002053 | GBP1 2633 Hs.62661 202269_x 1 GO:00058 - BC002666 guanylate binding protein 1, chr1:8951 89517986 89531043 -1.41018 -16.5506 -6.47375 0.391149 0.011838 205671_s NM_002120 | HLA-DOB 3112 Hs.1802 205671_s 6 GO:00025 - NM_0021 major histocompatibility chr6:3278 32780540 32784825 -0.74433 -16.3183 -2.7444 0.168179 0.149104 201195_s NM_003486 | SLC7A5 8140 Hs.51379 201195_s 16 GO:00065 - AB018009 solute carrier family 7 (cationic chr16:878 87863629 87903100 -1.99995 -16.2066 -3.27376 0.202002 0.103241 206341_a NM_000417 | IL2RA 3559 Hs.23136 206341_a 10 GO:00024 - NM_0004 interleukin 2 receptor, alpha chr10:605 6052656 6104333 -0.65546 -16.0772 -5.08148 0.316067 0.029822 209378_s NM_018999 | FAM190B 54462 Hs.46198 209378_s 10 NA + AI478879 family with sequence similarity chr10:860 86088409 86278276 -0.28266 -16.0227 -1.3346 0.083294 0.39667 200998_s NM_006825 | CKAP4 10970 Hs.74368 200998_s 12 GO:00160 - AW02961 cytoskeleton-associated chr12:106 1.07E+08 1.07E+08 -2.22253 -15.9334 -3.15995 0.198322 0.111624 209210_s NM_001134999 FERMT2 10979 Hs.50934 209210_s 14 GO:00300 - Z24725 fermitin family homolog 2 chr14:533 53326206 53417815 -0.30393 -15.7555 -4.74641 0.301255 0.036207 206058_a NM_001122847 SLC6A12 6539 Hs.43717 206058_a 12 GO:00068 - U27699 solute carrier family 6 chr12:299 299251 322492 -0.69199 -15.668 -3.01297 0.192301 0.125092 219584_a NM_015900 | PLA1A 51365 Hs.43745 219584_a 3 GO:00066 + NM_0159 member A chr3:1193 1.19E+08 1.19E+08 1.030889 -15.5964 -5.077 0.325523 0.02986 200629_a NM_004184 | WARS 7453 Hs.49759 200629_a 14 GO:00064 - NM_0041 tryptophanyl-tRNA synthetase chr14:100 1.01E+08 1.01E+08 -3.15997 -15.4986 -3.10264 0.200188 0.116318 204135_a NM_001042459 FILIP1L 11259 Hs.10467 204135_a 3 GO:00081 - NM_0148 filamin A interacting protein 1- chr3:9956 99566772 99833349 -0.97377 -15.0673 -1.65549 0.109873 0.318136 201564_s NM_003088 | FSCN1 6624 Hs.11840 201564_s 7 GO:00510 + NM_0030 fascin homolog 1, actin- chr7:5632 5632453 5646285 -1.72293 -14.9922 -3.85891 0.257394 0.070387 205013_s NA NA NA NA 205013_s NA NA NA NM_0006 NA chrNA:-1-- -1 -1 -0.83466 -14.9255 -3.18737 0.213552 0.109901 200920_s NM_001731 | BTG1 694 Hs.25593 200920_s 12 GO:00082 - AL535380 B-cell translocation gene 1, anti- chr12:925 92534053 92539673 -2.33976 -14.8269 -2.13823 0.144213 0.228068 204929_s NM_006634 | VAMP5 10791 Hs.53437 204929_s 2 GO:00161 + NM_0066 vesicle-associated membrane chr2:8581 85811530 85820511 -0.84684 -14.7967 -3.89472 0.263216 0.066778 202693_s NM_004760 | STK17A 9263 Hs.70948 202693_s 7 GO:00069 + AW19473 serine/ kinase 17a chr7:4362 43622691 43666977 -1.27931 -14.5895 -3.18622 0.218391 0.108747 213060_s NM_001025197 CHI3L2 1117 Hs.51484 213060_s 1 GO:00059 + U58515 3-like 2 chr1:1117 1.12E+08 1.12E+08 0.162308 -14.5609 -3.58464 0.246182 0.08236 210538_s NM_001165 | BIRC3 330 Hs.12779 210538_s 11 GO:00069 + U37546 baculoviral IAP repeat- chr11:102 1.02E+08 1.02E+08 -0.14152 -14.4021 -3.04358 0.211329 0.12262 205153_s NM_001250 | CD40 958 Hs.47286 205153_s 20 GO:00027 + NM_0012 CD40 molecule, TNF receptor chr20:447 44746905 44758384 -0.81461 -14.2386 -3.77071 0.264822 0.072531 ©216298_a 2016NA AmericanNA NAMedicalNA Association.216298_a NA NA All NArightsAL580863 reserved.NA chrNA:-1-- -1 -1 0.560481 -14.2293 -1.74812 0.122853 0.296787

Downloaded From: https://jamanetwork.com/ on 09/30/2021 213497_a NM_145804 | ABTB2 25841 Hs.23361 213497_a 11 GO:00015 - AL050374 ankyrin repeat and BTB (POZ) chr11:341 34172534 34378802 0.21671 -14.1314 -2.57889 0.182494 0.166508 201976_s NM_012334 | MYO10 4651 Hs.48172 201976_s 5 GO:00071 - NM_0123 myosin X chr5:1666 16662016 16936385 -1.51941 -14.0997 -4.29318 0.304487 0.050434 218699_a NM_001135662 RAB7L1 8934 Hs.11532 218699_a 1 GO:00072 - BG338251 RAB7, member RAS oncogene chr1:2057 2.06E+08 2.06E+08 0.883087 -14.0992 -2.58059 0.183031 0.166549 213159_a NM_014982 | PCNX 22990 Hs.44655 213159_a 14 GO:00160 + AB018348 pecanex homolog (Drosophila) chr14:713 71374121 71582099 0.174654 -14.0163 -3.19956 0.228274 0.108809 205681_a NM_001114735 BCL2A1 597 Hs.22781 205681_a 15 GO:00069 - NM_0040 BCL2-related protein A1 chr15:802 80253232 80263643 -0.74289 -14.0007 -5.14103 0.367199 0.029191 220984_s NM_001146008 SLCO5A1 81796 Hs.15246 220984_s 8 GO:00068 - NM_0309 solute carrier organic anion chr8:7058 70584569 70747299 1.365016 -13.8912 -2.81703 0.202793 0.140792 202796_a NM_001109974 SYNPO 11346 Hs.43522 202796_a 5 GO:00058 + NM_0072 synaptopodin chr5:1499 1.5E+08 1.5E+08 -1.2509 -13.8907 -2.72072 0.195866 0.151384 203708_a NM_001037339 PDE4B 5142 Hs.19807 203708_a 1 GO:00071 + NM_0026 phosphodiesterase 4B, cAMP- chr1:6625 66258192 66840261 -1.05077 -13.8724 -4.91956 0.354629 0.034143 204781_s NM_000043 | FAS 355 Hs.24413 204781_s 10 GO:00071 + NM_0000 Fas (TNF receptor superfamily, chr10:907 90750287 90775541 -0.86919 -13.7723 -3.42122 0.248412 0.092083 210563_x NM_001127183 CFLAR 8837 Hs.39073 210563_x 2 GO:00065 + U97075 CASP8 and FADD-like apoptosis chr2:2019 2.02E+08 2.02E+08 -0.13828 -13.7358 -2.34452 0.170687 0.197686 203149_a NM_001042724 PVRL2 5819 Hs.65545 203149_a 19 GO:00028 + NM_0028 poliovirus receptor-related 2 chr19:453 45349392 45382197 -1.16569 -13.7196 -2.31011 0.168381 0.202063 205483_s NM_005101 | ISG15 9636 Hs.45848 205483_s 1 GO:00199 + NM_0051 ISG15 ubiquitin-like modifier chr1:9488 948846 949915 -0.76948 -13.5214 -4.31007 0.318758 0.051915 204070_a NM_004585 | RARRES3 5920 Hs.17466 204070_a 11 GO:00082 + NM_0045 chr11:633 63304272 63313929 -0.98523 -13.3298 -4.21714 0.31637 0.054628 207176_s NM_005191 | CD80 941 Hs.838 207176_s 3 GO:00072 - NM_0051 CD80 molecule chr3:1192 1.19E+08 1.19E+08 -0.55007 -13.1711 -3.17895 0.241358 0.108738 205798_a NM_002185 | IL7R 3575 Hs.59174 205798_a 5 GO:00000 + NM_0021 interleukin 7 receptor chr5:3585 35856990 35876921 -0.727 -13.1461 -3.71047 0.282249 0.074381 218400_a NM_006187 | OAS3 4940 Hs.52863 218400_a 12 GO:00061 + NM_0061 2'-5'-oligoadenylate synthetase chr12:113 1.13E+08 1.13E+08 0.837801 -13.131 -3.03654 0.231249 0.123805 202672_s NM_001030287 ATF3 467 Hs.460 202672_s 1 GO:00060 + NM_0016 activating transcription factor 3 chr1:2127 2.13E+08 2.13E+08 -1.28489 -13.067 -2.99604 0.229284 0.124795 221087_s NM_014349 | APOL3 80833 Hs.47473 221087_s 22 GO:00068 - NM_0143 apolipoprotein L, 3 chr22:365 36536371 36562225 1.397734 -13.0051 -3.59748 0.276621 0.08407 208864_s NM_003329 | TXN 7295 Hs.43513 208864_s 9 GO:00071 - AF313911 thioredoxin chr9:1130 1.13E+08 1.13E+08 -0.34571 -12.9634 -2.85108 0.219933 0.14057 210582_s NM_001031801 LIMK2 3985 Hs.47459 210582_s 22 GO:00064 + AL117466 LIM domain kinase 2 chr22:316 31608249 31676064 -0.13602 -12.9541 -2.83616 0.21894 0.13817 219210_s NM_016530 | RAB8B 51762 Hs.38973 219210_s 15 GO:00072 + NM_0165 RAB8B, member RAS oncogene chr15:634 63481727 63559971 0.965657 -12.944 -2.71017 0.209377 0.154815 202748_a NM_004120 | GBP2 2634 Hs.38656 202748_a 1 GO:00069 - NM_0041 guanylate binding protein 2, chr1:8957 89573309 89591799 -1.26403 -12.7569 -4.66086 0.36536 0.041133 204348_s NM_001005353 AK3L1 205 Hs.10862 204348_s 1 GO:00061 + NM_0134 adenylate kinase 3-like 1 chr1:6561 65613231 65693173 -0.93856 -12.7209 -2.76831 0.217619 0.146695 210285_x NM_004906 | WTAP 9589 Hs.44609 210285_x 6 GO:00063 + BC000383 Wilms tumor 1 associated chr6:1601 1.6E+08 1.6E+08 -0.17166 -12.7103 -2.28329 0.179641 0.206014 205378_s NM_000665 | ACHE 43 Hs.15449 205378_s 7 GO:00062 - NM_0158 (Yt blood chr7:1004 1E+08 1E+08 -0.78366 -12.6924 -3.62735 0.28579 0.078868 210007_s NM_000408 | GPD2 2820 Hs.51238 210007_s 2 GO:00060 + U36310 glycerol-3-phosphate chr2:1572 1.57E+08 1.57E+08 -0.20601 -12.6389 -2.45514 0.194253 0.182084 206486_a NM_002286 | LAG3 3902 Hs.40952 206486_a 12 GO:00071 + NM_0022 lymphocyte-activation gene 3 chr12:688 6881669 6887619 -0.63737 -12.6222 -2.45629 0.194601 0.181048 205992_s NM_000585 | IL15 3600 Hs.65437 205992_s 4 GO:00018 + NM_0005 interleukin 15 chr4:1425 1.43E+08 1.43E+08 -0.70036 -12.6171 -3.95526 0.313484 0.063694 204748_a NM_000963 | PTGS2 5743 Hs.19638 204748_a 1 GO:00517 - NM_0009 prostaglandin-endoperoxide chr1:1866 1.87E+08 1.87E+08 -0.8743 -12.5942 -3.63915 0.288954 0.081359 211729_x NM_000712 | BLVRA 644 Hs.48814 211729_x 7 GO:00551 + BC005902 biliverdin reductase A chr7:4379 43798271 43846936 -0.00155 -12.5261 -1.39933 0.111713 0.378669 205330_a NM_002430 | MN1 4330 Hs.26851 205330_a 22 GO:00081 - NM_0024 meningioma (disrupted in chr22:281 28144265 28197486 -0.79027 -12.5175 -2.37057 0.18938 0.192611 200628_s NM_004184 | WARS 7453 Hs.49759 200628_s 14 GO:00064 - M61715 tryptophanyl-tRNA synthetase chr14:100 1.01E+08 1.01E+08 -3.16569 -12.3813 -2.44713 0.197647 0.181496 209959_a NM_006981 | NR4A3 8013 Hs.27952 209959_a 9 GO:00017 + U12767 nuclear receptor subfamily 4, chr9:1025 1.03E+08 1.03E+08 -0.21161 -12.3238 -2.52102 0.204566 0.173802 215223_s NM_000636 | SOD2 6648 Hs.48704 215223_s 6 GO:00013 - W46388 superoxide dismutase 2, chr6:1601 1.6E+08 1.6E+08 0.428047 -12.2642 -3.58067 0.291961 0.085855 203571_s NM_006829 | C10orf11 10974 Hs.64266 203571_s 10 GO:00081 + NM_0068 chromosome 10 open reading chr10:887 88728187 88730666 -1.07828 -12.1808 -2.858 0.234632 0.138443 203771_s NM_000712 | BLVRA 644 Hs.48814 203771_s 7 GO:00551 + AA74018 biliverdin reductase A chr7:4379 43798271 43846936 -1.0383 -12.1614 -1.96865 0.161876 0.253666 219352_a NM_001165136 HERC6 55008 Hs.52931 219352_a 4 GO:00199 + NM_0179 hect domain and RLD 6 chr4:8929 89299890 89364248 0.99021 -12.0913 -3.55685 0.294166 0.083871 210072_a NM_006274 | CCL19 6363 Hs.50002 210072_a 9 GO:00096 - U88321 chemokine (C-C motif) ligand 19 chr9:3468 34689568 34691274 -0.19793 -12.0635 -7.01762 0.581726 0.008974 206503_x NM_002675 | PML 5371 Hs.52646 206503_x 15 GO:00016 + NM_0026 promyelocytic leukemia chr15:742 74287013 74328734 -0.63528 -11.9438 -1.78306 0.149288 0.291504 204141_a NM_001069 | TUBB2A 7280 Hs.65454 204141_a 6 GO:00070 - NM_0010 tubulin, beta 2A chr6:3153 3153903 3157783 -0.97271 -11.9352 -4.72207 0.395643 0.037644 215161_a NM_020439 | CAMK1G 57172 Hs.19906 215161_a 1 GO:00064 + AW01603 calcium/calmodulin-dependent chr1:2097 2.1E+08 2.1E+08 0.420089 -11.8981 -2.30197 0.193475 0.203307 201315_x NM_006435 | IFITM2 10581 Hs.70932 201315_x 11 GO:00069 + NM_0064 interferon induced chr11:308 308106 309409 -1.89662 -11.8824 -2.32138 0.195363 0.198896 203372_s NM_003877 | SOCS2 8835 Hs.48557 203372_s 12 GO:00199 + AB004903 suppressor of cytokine signaling chr12:939 93963597 93969978 -1.11804 -11.8561 -3.63531 0.30662 0.077876 215346_a NM_001250 | CD40 958 Hs.47286 215346_a 20 GO:00027 + BF664114 CD40 molecule, TNF receptor chr20:447 44746905 44758384 0.443529 -11.8508 -3.55866 0.300289 0.086799 219014_a NM_001130715 PLAC8 51316 Hs.54639 219014_a 4 NA - NM_0166 placenta-specific 8 chr4:8401 84015306 84035911 0.933985 -11.8394 -1.91859 0.162052 0.264748 219863_a NM_016323 | HERC5 51191 Hs.26663 219863_a 4 GO:00000 + NM_0163 hect domain and RLD 5 chr4:8937 89378267 89427305 1.086382 -11.8261 -3.81649 0.322716 0.071083 © 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 206359_a NM_003955 | SOCS3 9021 Hs.52797 206359_a 17 GO:00199 - BG035761 suppressor of cytokine signaling chr17:763 76352858 76356158 -0.65297 -11.7612 -4.21908 0.358727 0.052447 218047_a NM_024586 | OSBPL9 114883 Hs.21938 218047_a 1 GO:00068 + NM_0245 oxysterol binding protein-like 9 chr1:5208 52082763 52254136 0.788329 -11.6248 -2.07306 0.178331 0.235756 202732_a NM_007066 | PKIG 11142 Hs.47283 202732_a 20 GO:00001 + NM_0070 protein kinase (cAMP- chr20:431 43160435 43247677 -1.26872 -11.6241 -2.93871 0.252812 0.128548 204347_a NM_001005353 AK3L1 205 Hs.10862 204347_a 1 GO:00061 + AI653169 adenylate kinase 3-like 1 chr1:6561 65613231 65693173 -0.93873 -11.616 -1.9131 0.164695 0.263565 205568_a NM_020980 | AQP9 366 Hs.10462 205568_a 15 GO:00081 + NM_0209 aquaporin 9 chr15:584 58430407 58478110 -0.75782 -11.6021 -3.09312 0.266601 0.116061 205552_s NM_001032409 OAS1 4938 Hs.52476 205552_s 12 GO:00061 + NM_0025 2',5'-oligoadenylate synthetase chr12:113 1.13E+08 1.13E+08 -0.76012 -11.5878 -1.9351 0.166995 0.261038 221432_s NM_031212 | SLC25A28 81894 Hs.40379 221432_s 10 GO:00068 - NM_0312 solute carrier family 25, chr10:101 1.01E+08 1.01E+08 1.52519 -11.5483 -2.75156 0.238266 0.149388 205229_s NM_001135058 COCH 1690 Hs.21016 205229_s 14 GO:00076 + AA66933 coagulation factor C homolog, chr14:313 31343740 31359822 -0.80401 -11.5473 -3.34614 0.289778 0.095495 221942_s NM_000856 | GUCY1A3 2982 Hs.24258 221942_s 4 GO:00072 + AI719730 1, soluble, chr4:1565 1.57E+08 1.57E+08 1.791647 -11.5347 -2.80604 0.24327 0.143395 205569_a NM_014398 | LAMP3 27074 Hs.51844 205569_a 3 GO:00082 - NM_0143 lysosomal-associated chr3:1828 1.83E+08 1.83E+08 -0.75769 -11.5266 -6.19615 0.537552 0.015384 211267_a NM_003865 | HESX1 8820 Hs.17198 211267_a 3 GO:00063 - U82811 HESX homeobox 1 chr3:5723 57231946 57234280 -0.05499 -11.5224 -3.55961 0.308931 0.082274 217995_a NM_021199 | SQRDL 58472 Hs.51125 217995_a 15 GO:00551 + NM_0211 sulfide quinone reductase-like chr15:459 45927255 45983478 0.781008 -11.4469 -1.46443 0.127932 0.36228 215195_a NM_002737 | PRKCA 5578 Hs.53170 215195_a 17 GO:00001 + AF035594 protein kinase C, alpha chr17:642 64298925 64806862 0.424374 -11.4245 -0.79594 0.06967 0.576155 204204_a NM_001860 | SLC31A2 1318 Hs.24030 204204_a 9 GO:00068 + NM_0018 solute carrier family 31 (copper chr9:1159 1.16E+08 1.16E+08 -0.96189 -11.3967 -2.23036 0.195703 0.21125 206026_s NM_007115 | TNFAIP6 7130 Hs.43732 206026_s 2 GO:00071 + NM_0071 tumor necrosis factor, alpha- chr2:1522 1.52E+08 1.52E+08 -0.69581 -11.388 -5.00549 0.439541 0.033032 209546_s NM_001136540 APOL1 8542 Hs.11430 209546_s 22 GO:00066 + AF323540 apolipoprotein L, 1 chr22:366 36649116 36663576 -0.26185 -11.3691 -2.68906 0.236523 0.153229 221486_a NM_004436 | ENSA 2029 Hs.63245 221486_a 1 GO:00068 - AF067170 endosulfine alpha chr1:1505 1.51E+08 1.51E+08 1.54831 -11.3532 -1.37067 0.120729 0.385971 220132_s NM_001004419 CLEC2D 29121 Hs.26832 220132_s 12 GO:00071 + NM_0132 C-type lectin domain family 2, chr12:982 9822308 9852039 1.141178 -11.3476 -3.16668 0.279063 0.110973 209765_a NM_023038 | ADAM19 8728 Hs.48394 209765_a 5 GO:00065 - Y13786 ADAM metallopeptidase chr5:1569 1.57E+08 1.57E+08 -0.23525 -11.3277 -3.61792 0.319386 0.083816 212067_s NM_001733 | C1R 715 Hs.52422 212067_s 12 GO:00065 - AL573058 complement component 1, r chr12:718 7187516 7245043 0.038665 -11.3125 -3.8847 0.343398 0.065054 219159_s NM_021181 | SLAMF7 57823 Hs.51726 219159_s 1 GO:00071 + NM_0211 SLAM family member 7 chr1:1607 1.61E+08 1.61E+08 0.956883 -11.2982 -4.94819 0.437961 0.034643 215806_x NA NA NA NA 215806_x NA NA NA M13231 NA chrNA:-1-- -1 -1 0.499719 -11.2107 -1.39725 0.124635 0.380291 219211_a NM_017414 | USP18 11274 Hs.38260 219211_a 22 GO:00065 + NM_0174 ubiquitin specific peptidase 18 chr22:186 18632757 18660160 0.965847 -11.2093 -3.69768 0.329878 0.075463 243_g_at NM_001134364 MAP4 4134 Hs.51794 243_g_at 3 GO:00070 - M64571 microtubule-associated protein chr3:4801 48014569 48130769 2.202837 -11.1776 -2.16022 0.193263 0.226016 209545_s NM_003821 | RIPK2 8767 Hs.10375 209545_s 8 GO:00071 + AF064824 receptor-interacting serine- chr8:9076 90769974 90803291 -0.26193 -11.1664 -1.99637 0.178783 0.251175 218169_a NM_018052 | VAC14 55697 Hs.44506 218169_a 16 GO:00071 - NM_0180 Vac14 homolog (S. cerevisiae) chr16:707 70721343 70835061 0.804819 -11.0995 -1.74872 0.157549 0.297926 214995_s NA NA NA NA 214995_s NA NA NA BF508948 NA chrNA:-1-- -1 -1 0.400218 -11.0967 -1.66436 0.149987 0.313977 202193_a NM_001031801 LIMK2 3985 Hs.47459 202193_a 22 GO:00064 + NM_0055 LIM domain kinase 2 chr22:316 31608249 31676064 -1.43629 -11.0234 -3.53652 0.32082 0.083985 201162_a NM_001553 | IGFBP7 3490 Hs.47980 201162_a 4 GO:00015 - NM_0015 insulin-like growth factor chr4:5789 57897245 57976539 -2.03087 -10.9165 -2.67282 0.244843 0.158289 204140_a NM_003596 | TPST1 8460 Hs.42119 204140_a 7 GO:00064 + NM_0035 tyrosylprotein sulfotransferase chr7:6567 65670258 65825437 -0.97297 -10.8715 -3.05287 0.280815 0.118048 206502_s NM_002196 | INSM1 3642 Hs.89584 206502_s 20 GO:00301 + NM_0021 insulinoma-associated 1 chr20:203 20348764 20351590 -0.63539 -10.8308 -0.98539 0.09098 0.504813 201648_a NM_002227 | JAK1 3716 Hs.20753 201648_a 1 GO:00071 - AL039831 Janus kinase 1 chr1:6529 65298905 65432187 -1.6758 -10.7684 -1.1235 0.104333 0.459702 206025_s NM_007115 | TNFAIP6 7130 Hs.43732 206025_s 2 GO:00071 + AW18819 tumor necrosis factor, alpha- chr2:1522 1.52E+08 1.52E+08 -0.69593 -10.7552 -5.8806 0.546768 0.018552 209683_a NM_030797 | FAM49A 81553 Hs.46776 209683_a 2 GO:00056 - AA24365 family with sequence similarity chr2:1673 16730731 16847134 -0.24585 -10.715 -1.60475 0.149766 0.329713 206421_s NM_001040147 SERPINB7 8710 Hs.13820 206421_s 18 GO:00158 + NM_0037 serpin peptidase inhibitor, chr18:614 61420276 61472603 -0.64521 -10.7049 -4.06468 0.379703 0.060306 202310_s NM_000088 | COL1A1 1277 Hs.17292 202310_s 17 GO:00015 - K01228 collagen, type I, alpha 1 chr17:482 48261458 48279000 -1.3964 -10.7043 -2.57485 0.240543 0.166807 208747_s NM_001734 | C1S 716 Hs.45835 208747_s 12 GO:00065 + M18767 complement component 1, s chr12:716 7167979 7178333 -0.35953 -10.6555 -3.90226 0.366221 0.069834 213562_s NM_003129 | SQLE 6713 Hs.71465 213562_s 8 GO:00551 + BF979497 squalene epoxidase chr8:1260 1.26E+08 1.26E+08 0.224472 -10.6123 -1.7455 0.16448 0.297816 217388_s NM_001032998 KYNU 8942 Hs.47012 217388_s 2 GO:00081 + D55639 kynureninase (L-kynurenine chr2:1436 1.44E+08 1.44E+08 0.698779 -10.6082 -1.80936 0.170563 0.283549 203680_a NM_002736 | PRKAR2B 5577 Hs.43306 203680_a 7 GO:00019 + NM_0027 protein kinase, cAMP- chr7:1066 1.07E+08 1.07E+08 -1.05621 -10.5042 -4.12134 0.392351 0.057977 204224_s NM_000161 | GCH1 2643 Hs.62490 204224_s 14 GO:00510 - NM_0001 GTP cyclohydrolase 1 chr14:553 55308723 55369542 -0.95866 -10.4946 -5.40728 0.515242 0.025605 202464_s NM_001145443 PFKFB3 5209 Hs.19547 202464_s 10 GO:00081 + NM_0045 6-phosphofructo-2- chr10:618 6186842 6277505 -1.34703 -10.4823 -2.5461 0.242895 0.170482 201543_s NM_001142648 SAR1A 56681 Hs.49996 201543_s 10 GO:00161 - NM_0201 SAR1 homolog A (S. cerevisiae) chr10:719 71909966 71930285 -1.73579 -10.447 -1.64156 0.157132 0.321911 218404_a NM_013322 | SNX10 29887 Hs.52071 218404_a 7 GO:00071 + NM_0133 sorting nexin 10 chr7:2633 26331514 26413937 0.838406 -10.4199 -3.88009 0.372374 0.065224 217739_s NM_005746 | NAMPT 10135 Hs.48961 217739_s 7 GO:00071 - NM_0057 nicotinamide chr7:1058 1.06E+08 1.06E+08 0.746567 -10.3932 -2.36403 0.227459 0.191812 ©204401_a 2016NM_002250 American | KCNN4 Medical3783 Hs.10082 Association.204401_a 19 GO:00069 All -rightsNM_0022 reserved.potassium intermediate/small chr19:442 44270686 44285409 -0.93024 -10.3223 -1.35285 0.13106 0.391561

Downloaded From: https://jamanetwork.com/ on 09/30/2021 209270_a NM_000228 | LAMB3 3914 Hs.49763 209270_a 1 GO:00071 - L25541 laminin, beta 3 chr1:2097 2.1E+08 2.1E+08 -0.29583 -10.2818 -2.67511 0.260178 0.157926 213693_s NM_001018016 MUC1 4582 Hs.89603 213693_s 1 GO:00075 - AI610869 mucin 1, cell surface associated chr1:1551 1.55E+08 1.55E+08 0.240412 -10.2714 -1.99685 0.194409 0.248179 205377_s NM_000665 | ACHE 43 Hs.15449 205377_s 7 GO:00062 - AI190022 acetylcholinesterase (Yt blood chr7:1004 1E+08 1E+08 -0.78377 -10.2401 -3.32958 0.325153 0.098051 213361_a NM_014290 | TDRD7 23424 Hs.19384 213361_a 9 GO:00072 + AW12959 tudor domain containing 7 chr9:1001 1E+08 1E+08 0.199799 -10.2106 -2.20773 0.216219 0.215565 212203_x NM_021034 | IFITM3 10410 Hs.37465 212203_x 11 GO:00069 - BF338947 interferon induced chr11:319 319672 320914 0.05553 -10.1687 -2.1493 0.211364 0.226249 210087_s NM_001146191 MPZL1 9019 Hs.49391 210087_s 1 GO:00071 + AF095727 myelin protein zero-like 1 chr1:1676 1.68E+08 1.68E+08 -0.19616 -10.1615 -2.16325 0.212887 0.22209 207500_a NM_001136109 CASP5 838 Hs.21332 207500_a 11 GO:00065 - NM_0043 caspase 5, apoptosis-related chr11:104 1.05E+08 1.05E+08 -0.51006 -10.149 -1.70485 0.167982 0.304375 207614_s NM_003592 | CUL1 8454 Hs.14680 207614_s 7 GO:00000 + NM_0035 cullin 1 chr7:1483 1.48E+08 1.48E+08 -0.4961 -10.1385 -2.44714 0.24137 0.185985 202643_s NM_006290 | TNFAIP3 7128 Hs.21160 202643_s 6 GO:00199 + AI738896 tumor necrosis factor, alpha- chr6:1381 1.38E+08 1.38E+08 -1.29337 -10.1119 -2.51002 0.248225 0.179053 200921_s NM_001731 | BTG1 694 Hs.25593 200921_s 12 GO:00082 - NM_0017 B-cell translocation gene 1, anti- chr12:925 92534053 92539673 -2.33833 -10.0858 -1.72013 0.17055 0.303304 204121_a NM_006705 | GADD45G 10912 Hs.9701 204121_a 9 GO:00001 + NM_0067 growth arrest and DNA-damage- chr9:9221 92219926 92221467 -0.97627 -10.0709 -2.26524 0.22493 0.210454 207196_s NM_006058 | TNIP1 10318 Hs.35514 207196_s 5 GO:00069 - NM_0060 TNFAIP3 interacting protein 1 chr5:1504 1.5E+08 1.5E+08 -0.54762 -10.0624 -1.96257 0.195039 0.256622 217502_a NM_001547 | IFIT2 3433 Hs.43760 217502_a 10 GO:00081 + BE888744 interferon-induced protein chr10:910 91061705 91069032 0.714363 -10.0481 -3.31646 0.330057 0.097708 202687_s NM_003810 | TNFSF10 8743 Hs.47827 202687_s 3 GO:00071 - U57059 tumor necrosis factor (ligand) chr3:1722 1.72E+08 1.72E+08 -1.28064 -10.013 -4.28236 0.42768 0.055174 216252_x NM_000043 | FAS 355 Hs.24413 216252_x 10 GO:00071 + Z70519 Fas (TNF receptor superfamily, chr10:907 90750287 90775541 0.554885 -10.0048 -3.87521 0.387337 0.06969 214329_x NM_003810 | TNFSF10 8743 Hs.47827 214329_x 3 GO:00071 - AW47443 tumor necrosis factor (ligand) chr3:1722 1.72E+08 1.72E+08 0.318935 -9.99259 -4.37776 0.438101 0.048569 205241_a NM_001169109 SCO2 9997 Hs.18090 205241_a 22 GO:00551 - NM_0051 SCO cytochrome oxidase chr22:509 50961998 50964868 -0.8024 -9.99044 -3.0895 0.309245 0.119142 212662_a NM_001135768 PVR 5817 Hs.17184 212662_a 19 GO:00028 + BE615277 poliovirus receptor chr19:451 45147097 45162361 0.111969 -9.943 -3.07433 0.309196 0.117929 217475_s NM_001031801 LIMK2 3985 Hs.47459 217475_s 22 GO:00064 + AC002073 LIM domain kinase 2 chr22:316 31608249 31676064 0.710649 -9.87723 -2.69193 0.272539 0.152289 211126_s NM_001321 | CSRP2 1466 Hs.53090 211126_s 12 GO:00160 - U46006 cysteine and glycine-rich chr12:772 77252495 77272799 -0.07127 -9.84975 -1.58191 0.160604 0.332561 201063_a NM_002901 | RCN1 5954 Hs.97887 201063_a 11 GO:00057 + NM_0029 reticulocalbin 1, EF-hand chr11:321 32112476 32127271 -2.13953 -9.83501 -3.32974 0.33856 0.102678 211014_s NA NA NA NA 211014_s NA NA NA AF230410 NA chrNA:-1-- -1 -1 -0.08491 -9.80728 -2.10084 0.214212 0.23074 211555_s NM_000857 | GUCY1B3 2983 Hs.77890 211555_s 4 GO:00061 + AF020340 guanylate cyclase 1, soluble, chr4:1566 1.57E+08 1.57E+08 -0.02232 -9.80406 -2.39743 0.244535 0.187498 208527_x NM_003523 | HIST1H2B 8344 Hs.53436 208527_x 6 NA + NM_0035 histone cluster 1, H2be chr6:2618 26184023 26184457 -0.3863 -9.75512 -1.4561 0.149265 0.364936 219209_a NM_022168 | IFIH1 64135 Hs.16317 219209_a 2 GO:00096 - NM_0221 interferon induced with chr2:1631 1.63E+08 1.63E+08 0.965488 -9.74718 -2.7409 0.281199 0.147246 214343_s NM_020725 | ATXN7L1 222255 Hs.72320 214343_s 7 NA - AI017382 ataxin 7-like 1 chr7:1054 1.05E+08 1.06E+08 0.320859 -9.74368 -1.43399 0.147172 0.369192 210873_x NM_145699 | APOBEC3 200315 Hs.34898 210873_x 22 GO:00081 + U03891 apolipoprotein B mRNA editing chr22:393 39353526 39359188 -0.10105 -9.69795 -5.19006 0.535171 0.024822 203927_a NM_004556 | NFKBIE 4794 Hs.45827 203927_a 6 GO:00429 - NM_0045 nuclear factor of kappa chr6:4422 44225902 44233525 -1.01089 -9.67109 -1.94361 0.200971 0.259445 203915_a NM_002416 | CXCL9 4283 Hs.77367 203915_a 4 GO:00071 - NM_0024 chemokine (C-X-C motif) ligand chr4:7692 76922622 76928641 -1.01298 -9.65361 -5.86163 0.607196 0.020121 202073_a NM_001008211 OPTN 10133 Hs.33270 202073_a 10 GO:00000 + AV75767 optineurin chr10:131 13142081 13180276 -1.48121 -9.65174 -3.06607 0.31767 0.11889 217499_x NA NA NA NA 217499_x NA NA NA AW87430 NA chrNA:-1-- -1 -1 0.713954 -9.63914 -0.89078 0.092413 0.538957 218007_s NM_015920 | RPS27L 51065 Hs.10895 218007_s 15 GO:00062 - NM_0159 ribosomal protein S27-like chr15:634 63445539 63449741 0.782735 -9.6157 -1.03093 0.107213 0.488632 201496_x NM_001040113 MYH11 4629 Hs.46010 201496_x 16 GO:00069 - S67238 myosin, heavy chain 11, smooth chr16:157 15796993 15950887 -1.76439 -9.59584 -2.05026 0.213661 0.242647 202086_a NM_001144925 MX1 4599 Hs.51730 202086_a 21 GO:00069 + NM_0024 myxovirus (influenza virus) chr21:427 42792519 42831140 -1.47668 -9.57947 -3.57322 0.373008 0.086746 209813_x NA NA NA NA 209813_x NA NA NA M16768 NA chrNA:-1-- -1 -1 -0.22947 -9.47135 -1.53777 0.16236 0.344204 202307_s NM_000593 | TAP1 6890 Hs.35201 202307_s 6 GO:00069 - NM_0005 transporter 1, ATP-binding chr6:3281 32812986 32821748 -1.39732 -9.43916 -3.25249 0.344574 0.109205 209027_s NM_001012750 ABI1 10006 Hs.50814 209027_s 10 GO:00071 - BF673013 abl-interactor 1 chr10:270 27035526 27149959 -0.32548 -9.40639 -1.1329 0.120439 0.45514 208389_s NM_004171 | SLC1A2 6506 Hs.50233 208389_s 11 GO:00068 - NM_0041 solute carrier family 1 (glial high chr11:352 35272752 35441105 -0.40308 -9.40217 -1.20311 0.127961 0.434503 214441_a NM_005819 | STX6 10228 Hs.51841 214441_a 1 GO:00069 - NM_0058 6 chr1:1809 1.81E+08 1.81E+08 0.332889 -9.39222 -1.06583 0.11348 0.476607 203828_s NM_001012631 IL32 9235 Hs.943 203828_s 16 GO:00069 + NM_0042 interleukin 32 chr16:311 3115312 3119667 -1.02761 -9.35503 -3.7406 0.399849 0.078845 208633_s NM_012090 | MACF1 23499 Hs.47247 208633_s 1 GO:00017 + W61052 microtubule-actin crosslinking chr1:3954 39547117 39952789 -0.37324 -9.33631 -1.2709 0.136124 0.415357 204971_a NM_005213 | CSTA 1475 Hs.51819 204971_a 3 GO:00104 + NM_0052 cystatin A (stefin A) chr3:1220 1.22E+08 1.22E+08 -0.84084 -9.33059 -2.27324 0.243633 0.207324 208969_a NM_005002 | NDUFA9 4704 Hs.75227 208969_a 12 GO:00061 + AF050641 NADH dehydrogenase chr12:475 4758282 4796397 -0.33289 -9.32896 -1.38357 0.148309 0.381218 204804_a NM_003141 | TRIM21 6737 Hs.53235 204804_a 11 GO:00702 - NM_0031 tripartite motif-containing 21 chr11:440 4406126 4414926 -0.86559 -9.32711 -1.53731 0.164822 0.344963 202570_s NM_001042486 DLGAP4 22839 Hs.24960 202570_s 20 GO:00072 + BF346592 discs, large (Drosophila) chr20:349 34995443 35157038 -1.31532 -9.26885 -1.20878 0.130414 0.431109 202531_a NM_002198 | IRF1 3659 Hs.43606 202531_a 5 GO:00433 - NM_0021 interferon regulatory factor 1 chr5:1318 1.32E+08 1.32E+08 -1.32658 -9.26017 -3.02626 0.326805 0.122927

© 2016 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 09/30/2021 212817_a NM_001135004 DNAJB5 25822 Hs.23750 212817_a 9 GO:00064 + AK023253 DnaJ (Hsp40) homolog, chr9:3498 34989724 34998428 0.131863 -8.51045 -0.61182 0.07189 0.65416 214022_s NM_003641 | IFITM1 8519 Hs.45841 214022_s 11 GO:00071 + AA74910 interferon induced chr11:313 313990 315271 0.281039 -8.4991 -4.7418 0.557918 0.042255 210999_s NM_001001549 GRB10 2887 Hs.16406 210999_s 7 GO:00071 - U66065 growth factor receptor-bound chr7:5065 50657759 50861159 -0.08642 -8.47157 -1.91595 0.226162 0.264938 205633_s NM_000688 | ALAS1 211 Hs.47630 205633_s 3 GO:00067 + NM_0006 aminolevulinate, delta-, chr3:5223 52232115 52248343 -0.74929 -8.4599 -1.7336 0.204919 0.297181 213173_a NM_014982 | PCNX 22990 Hs.44655 213173_a 14 GO:00160 + AI815033 pecanex homolog (Drosophila) chr14:713 71374121 71582099 0.176172 -8.43916 -2.70957 0.321071 0.149198 207667_s NM_002756 | MAP2K3 5606 Hs.51401 207667_s 17 GO:00071 + NM_0027 mitogen-activated protein chr17:211 21187967 21218549 -0.49 -8.40599 -0.63337 0.075348 0.644557 212527_a NM_015704 | PPPDE2 27351 Hs.57045 212527_a 22 NA - BF057059 PPPDE peptidase domain chr22:419 41996935 42016916 0.095839 -8.40381 -1.61518 0.192196 0.329656 218627_a NM_018370 | DRAM1 55332 Hs.52563 218627_a 12 GO:00069 + NM_0183 DNA-damage regulated chr12:102 1.02E+08 1.02E+08 0.871752 -8.3685 -1.75693 0.209946 0.294272 201497_x NM_001040113 MYH11 4629 Hs.46010 201497_x 16 GO:00069 - NM_0228 myosin, heavy chain 11, smooth chr16:157 15796993 15950887 -1.76397 -8.36535 -2.23114 0.266712 0.209128 220987_s NA NA NA NA 220987_s NA NA NA NM_0309 NA chrNA:-1-- -1 -1 1.365973 -8.36487 -2.74545 0.328212 0.150107 221484_a NM_004776 | B4GALT5 9334 Hs.37048 221484_a 20 GO:00059 - BF691447 UDP-Gal:betaGlcNAc beta 1,4- chr20:482 48249484 48330421 1.547402 -8.36241 -2.2205 0.265534 0.210365 203091_a NM_003902 | FUBP1 8880 Hs.56738 203091_a 1 GO:00063 - NM_0039 far upstream element (FUSE) chr1:7841 78413592 78444777 -1.18005 -8.33687 -1.26639 0.151903 0.416053 201446_s NM_022037 | TIA1 7072 Hs.72316 201446_s 2 GO:00069 - BF692742 TIA1 cytotoxic granule- chr2:7043 70436576 70475779 -1.79728 -8.32337 -0.76396 0.091784 0.589253 208453_s NM_001167604 XPNPEP1 7511 Hs.39062 208453_s 10 GO:00065 - NM_0065 X-prolyl aminopeptidase chr10:111 1.12E+08 1.12E+08 -0.39558 -8.31109 -1.93994 0.233416 0.262664 200881_s NM_001539 | DNAJA1 3301 Hs.44520 200881_s 9 GO:00064 + NM_0015 DnaJ (Hsp40) homolog, chr9:3302 33025208 33039062 -2.41063 -8.30394 -1.56317 0.188245 0.339977 201508_a NM_001552 | IGFBP4 3487 Hs.46299 201508_a 17 GO:00015 + NM_0015 insulin-like growth factor chr17:385 38599675 38613981 -1.75576 -8.28545 -3.48839 0.421027 0.091343 213476_x NM_006086 | TUBB3 10381 Hs.51174 213476_x 16 GO:00070 + AL565749 tubulin, beta 3 chr16:899 89989744 90002505 0.21385 -8.28335 -1.89069 0.228252 0.270338 201037_a NM_002627 | PFKP 5214 Hs.26010 201037_a 10 GO:00060 + NM_0026 phosphofructokinase, platelet chr10:310 3109751 3178995 -2.17321 -8.28301 -2.40308 0.290121 0.191424 216950_s NA NA NA NA 216950_s NA NA NA X14355 NA chrNA:-1-- -1 -1 0.643309 -8.27211 -2.2496 0.27195 0.210947 219334_s NM_001031716 OBFC2A 64859 Hs.59161 219334_s 2 GO:00007 + NM_0228 oligonucleotide/oligosaccharid chr2:1925 1.93E+08 1.93E+08 0.987222 -8.26953 -2.4991 0.302206 0.171318 201762_s NM_002818 | PSME2 5721 Hs.43408 201762_s 14 GO:00311 - NM_0028 proteasome (prosome, chr14:246 24612574 24615855 -1.61772 -8.26893 -2.66165 0.321886 0.163874 202625_a NM_001111097 LYN 4067 Hs.69915 202625_a 8 GO:00025 + AI356412 v-yes-1 Yamaguchi sarcoma viral chr8:5679 56792385 56923936 -1.29876 -8.25769 -1.25612 0.152116 0.416627 213622_a NM_001852 | COL9A2 1298 Hs.41801 213622_a 1 GO:00015 - AI733465 collagen, type IX, alpha 2 chr1:4076 40766162 40782939 0.231659 -8.24344 -1.43265 0.173793 0.37184 211538_s NM_021979 | HSPA2 3306 Hs.43264 211538_s 14 GO:00069 + U56725 heat shock 70kDa protein 2 chr14:650 65007185 65009952 -0.02425 -8.22573 -1.23041 0.149581 0.423785 218995_s NM_001168319 EDN1 1906 Hs.51189 218995_s 6 GO:00015 + NM_0019 endothelin 1 chr6:1229 12290528 12297426 0.930705 -8.22442 -2.61804 0.318325 0.159806 215719_x NM_000043 | FAS 355 Hs.24413 215719_x 10 GO:00071 + X83493 Fas (TNF receptor superfamily, chr10:907 90750287 90775541 0.489506 -8.21566 -3.96033 0.482047 0.064768 213271_s NM_015018 | DOPEY1 23033 Hs.52024 213271_s 6 GO:00150 + AB029040 dopey family member 1 chr6:8377 83777384 83878127 0.1884 -8.21489 -1.76179 0.214463 0.294904 215768_a NA NA NA NA 215768_a NA NA NA AL049337 NA chrNA:-1-- -1 -1 0.495246 -8.19365 -2.82666 0.344981 0.138614 209610_s NM_001135581 SLC1A4 6509 Hs.65435 209610_s 2 GO:00068 + BF340083 solute carrier family 1 chr2:6521 65215578 65250997 -0.25463 -8.18729 -1.46777 0.179275 0.360571 216920_s NA NA NA NA 216920_s NA NA NA M27331 NA chrNA:-1-- -1 -1 0.63955 -8.18419 -1.69674 0.207319 0.309675 215146_s NM_001145418 TTC28 23331 Hs.38785 215146_s 22 GO:00054 - AB028966 tetratricopeptide repeat chr22:283 28374003 29075853 0.418321 -8.18376 -1.12046 0.136913 0.458083 209230_s NM_001042483 NUPR1 26471 Hs.51346 209230_s 16 GO:00160 - AF135266 nuclear protein, transcriptional chr16:285 28548661 28550495 -0.30117 -8.16135 -3.70942 0.45451 0.081251 204198_s NM_001031680 RUNX3 864 Hs.17001 204198_s 1 GO:00063 - AA54163 runt-related transcription factor chr1:2522 25226002 25291501 -0.96309 -8.15475 -1.20536 0.147811 0.435895 213524_s NM_015714 | G0S2 50486 Hs.43213 213524_s 1 GO:00070 + NM_0157 G0/G1switch 2 chr1:2098 2.1E+08 2.1E+08 0.21984 -8.1436 -3.71274 0.455909 0.080782 219364_a NM_024119 | DHX58 79132 Hs.55918 219364_a 17 GO:00450 - NM_0241 DEXH (Asp-Glu-X-His) box chr17:402 40253421 40264751 0.992325 -8.13884 -2.15 0.264166 0.225922 209803_s NM_003311 | PHLDA2 7262 Hs.15403 209803_s 11 GO:00069 - AF001294 pleckstrin homology-like chr11:294 2949502 2950650 -0.23054 -8.13151 -2.47298 0.304123 0.174523 201649_a NM_004223 | UBE2L6 9246 Hs.42577 201649_a 11 GO:00199 - NM_0042 ubiquitin-conjugating enzyme chr11:573 57319128 57335453 -1.67538 -8.12748 -1.95621 0.240691 0.257847 211012_s NA NA NA NA 211012_s NA NA NA BC000080 NA chrNA:-1-- -1 -1 -0.08517 -8.12246 -2.34447 0.28864 0.192398 210146_x NM_001080978 LILRB2 10288 Hs.65565 210146_x 19 GO:00069 - AF004231 leukocyte immunoglobulin-like chr19:547 54777675 54785033 -0.18865 -8.11974 -1.88396 0.232022 0.271155 218986_s NM_017631 | DDX60 55601 Hs.59171 218986_s 4 GO:00001 - NM_0176 DEAD (Asp-Glu-Ala-Asp) box chr4:1691 1.69E+08 1.69E+08 0.929202 -8.09481 -1.8558 0.229258 0.273927 202074_s NM_001008211 OPTN 10133 Hs.33270 202074_s 10 GO:00000 + NM_0219 optineurin chr10:131 13142081 13180276 -1.48085 -8.07689 -3.07284 0.380449 0.122297 213338_a NM_015444 | TMEM158 25907 Hs.35861 213338_a 3 GO:00160 - BF062629 transmembrane protein 158 chr3:4526 45265956 45267814 0.196902 -8.07433 -1.05856 0.131102 0.479789 207015_s NM_003888 | ALDH1A2 8854 Hs.64345 207015_s 15 GO:00018 - NM_0038 aldehyde dehydrogenase 1 chr15:582 58245627 58357906 -0.56962 -8.06771 -0.881 0.109201 0.542442 220941_s NM_001100420 C21orf91 54149 Hs.29381 220941_s 21 NA - NM_0174 chromosome 21 open reading chr21:191 19161284 19191703 1.351141 -8.06499 -1.74889 0.21685 0.295054 221563_a NM_007207 | DUSP10 11221 Hs.49782 221563_a 1 GO:00064 - N36770 dual specificity phosphatase 10 chr1:2218 2.22E+08 2.22E+08 1.58309 -8.05248 -1.17081 0.145397 0.445709 ©209893_s 2016NM_002033 American | FUT4 Medical2526 Hs.39042 Association.209893_s 11 GO:00059 All rights+ M58596 reserved.fucosyltransferase 4 (alpha (1,3) chr11:942 94277016 94283062 -0.21984 -8.04507 -1.5255 0.189619 0.345722

Downloaded From: https://jamanetwork.com/ on 09/30/2021 202720_a NM_015641 | TES 26136 Hs.59228 202720_a 7 GO:00057 + NM_0156 testis derived transcript (3 LIM chr7:1158 1.16E+08 1.16E+08 -1.27225 -9.16656 -1.18093 0.12883 0.440105 209928_s NM_005098 | MSC 9242 Hs.44261 209928_s 8 GO:00063 - AF060154 musculin (activated B-cell factor-chr8:7275 72753776 72756731 -0.21556 -9.1591 -3.43419 0.374949 0.090865 209372_x NA NA NA NA 209372_x NA NA NA BF971587 NA chrNA:-1-- -1 -1 -0.28345 -9.13675 -2.11033 0.230971 0.230371 218832_x NM_004041 | ARRB1 408 Hs.50328 218832_x 11 GO:00020 - NM_0040 arrestin, beta 1 chr11:749 74976481 75062873 0.9043 -9.11084 -0.8943 0.098158 0.538118 205040_a NM_000607 | ORM1 5004 Hs.52235 205040_a 9 GO:00026 + NM_0006 orosomucoid 1 chr9:1170 1.17E+08 1.17E+08 -0.83048 -9.07826 -2.82991 0.311724 0.137913 205120_s NM_000232 | SGCB 6443 Hs.43895 205120_s 4 GO:00070 - U29586 sarcoglycan, beta (43kDa chr4:5288 52886860 52904485 -0.81914 -9.06493 -1.52981 0.168762 0.345705 201999_s NM_006519 | DYNLT1 6993 Hs.44599 201999_s 6 GO:00058 - NM_0065 dynein, light chain, Tctex-type 1 chr6:1590 1.59E+08 1.59E+08 -1.50997 -9.04797 -1.83385 0.202681 0.281225 204994_a NM_002463 | MX2 4600 Hs.926 204994_a 21 GO:00069 + NM_0024 myxovirus (influenza virus) chr21:427 42733949 42780869 -0.83747 -9.04699 -2.65353 0.293305 0.160858 220363_s NM_133171 | ELMO2 63916 Hs.21046 220363_s 20 GO:00069 - NM_0220 engulfment and cell motility 2 chr20:449 44994689 45035271 1.194671 -9.04345 -1.95324 0.215984 0.259466 207386_a NM_004820 | CYP7B1 9420 Hs.66772 207386_a 8 GO:00551 - NM_0048 cytochrome P450, family 7, chr8:6550 65508528 65711348 -0.52434 -8.99435 -3.05452 0.339605 0.11534 204187_a NM_006877 | GMPR 2766 Hs.48474 204187_a 6 GO:00551 + NM_0068 guanosine monophosphate chr6:1623 16238810 16295778 -0.9649 -8.9467 -2.09039 0.23365 0.233611 201317_s NM_002787 | PSMA2 5683 Hs.33378 201317_s 7 GO:00096 - NM_0027 proteasome (prosome, chr7:4295 42956463 42971805 -1.89497 -8.94483 -2.02555 0.226449 0.241817 220297_a NM_001002860 BTBD7 55727 Hs.52554 220297_a 14 GO:00055 - NM_0181 BTB (POZ) domain containing 7 chr14:937 93753975 93799385 1.179264 -8.91578 -0.9095 0.102011 0.532018 218335_x NM_001161527 TNIP2 79155 Hs.36855 218335_x 4 GO:00072 - NM_0243 TNFAIP3 interacting protein 2 chr4:2743 2743386 2758103 0.828026 -8.91521 -1.64078 0.184043 0.320191 201601_x NM_003641 | IFITM1 8519 Hs.45841 201601_x 11 GO:00071 + NM_0036 interferon induced chr11:313 313990 315271 -1.70051 -8.88094 -4.72146 0.53164 0.04139 212646_a NM_015150 | RFTN1 23180 Hs.98910 212646_a 3 GO:00058 - D42043 raftlin, lipid raft linker 1 chr3:1635 16357352 16555222 0.109887 -8.87077 -2.34832 0.264726 0.199189 215078_a NM_000636 | SOD2 6648 Hs.48704 215078_a 6 GO:00013 - AL050388 superoxide dismutase 2, chr6:1601 1.6E+08 1.6E+08 0.410239 -8.87066 -2.28551 0.257648 0.20504 208436_s NM_001572 | IRF7 3665 Hs.16612 208436_s 11 GO:00001 - NM_0040 interferon regulatory factor 7 chr11:612 612555 615999 -0.39744 -8.86221 -2.76687 0.31221 0.146143 217197_x NM_001079691 N4BP2L1 90634 Hs.16122 217197_x 13 NA - AL049785 NEDD4 binding protein 2-like 1 chr13:329 32974860 33002315 0.674555 -8.85357 -1.60025 0.180746 0.331244 209239_a NM_001165412 NFKB1 4790 Hs.61843 209239_a 4 GO:00069 + M55643 nuclear factor of kappa light chr4:1034 1.03E+08 1.04E+08 -0.29996 -8.84472 -1.40282 0.158606 0.378832 210284_s NM_015093 | TAB2 23118 Hs.26977 210284_s 6 GO:00431 + AF241230 TGF-beta activated kinase chr6:1496 1.5E+08 1.5E+08 -0.17181 -8.82707 -0.80686 0.091407 0.571847 203620_s NM_014824 | FCHSD2 9873 Hs.57705 203620_s 11 GO:00055 - NM_0148 FCH and double SH3 domains 2 chr11:725 72547790 72853143 -1.06847 -8.80592 -1.69327 0.192287 0.307694 221241_s NM_030766 | BCL2L14 79370 Hs.21034 221241_s 12 GO:00429 + NM_0307 BCL2-like 14 (apoptosis chr12:122 12223877 12252625 1.452069 -8.80464 -3.97891 0.451911 0.060419 204385_a NM_001032998 KYNU 8942 Hs.47012 204385_a 2 GO:00081 + NM_0039 kynureninase (L-kynurenine chr2:1436 1.44E+08 1.44E+08 -0.93295 -8.80301 -1.90498 0.216401 0.264865 202695_s NM_004760 | STK17A 9263 Hs.70948 202695_s 7 GO:00069 + NM_0047 serine/threonine kinase 17a chr7:4362 43622691 43666977 -1.27875 -8.80113 -2.2616 0.256967 0.210915 210190_a NM_003764 | STX11 8676 Hs.11895 210190_a 6 GO:00161 + AF071504 syntaxin 11 chr6:1444 1.44E+08 1.45E+08 -0.18304 -8.79906 -2.2246 0.252823 0.216409 55692_at NM_133171 | ELMO2 63916 Hs.21046 55692_at 20 GO:00069 - W22924 engulfment and cell motility 2 chr20:449 44994689 45035271 3.054113 -8.79667 -2.19979 0.250071 0.21382 206724_a NM_003655 | CBX4 8535 Hs.40504 206724_a 17 GO:00001 - NM_0036 chromobox homolog 4 (Pc class chr17:778 77806955 77813213 -0.6071 -8.79253 -1.7015 0.193517 0.304324 219257_s NM_001142601 SPHK1 8877 Hs.68061 219257_s 17 GO:00066 + NM_0219 sphingosine kinase 1 chr17:743 74380689 74383941 0.973577 -8.78722 -2.58316 0.293968 0.16391 211075_s NM_001025079 CD47 961 Hs.44641 211075_s 3 GO:00071 - Z25521 CD47 molecule chr3:1077 1.08E+08 1.08E+08 -0.0776 -8.77808 -1.33688 0.152298 0.3938 203276_a NM_005573 | LMNB1 4001 Hs.89497 203276_a 5 GO:00160 + NM_0055 lamin B1 chr5:1261 1.26E+08 1.26E+08 -1.13828 -8.75164 -3.40449 0.389012 0.094465 205322_s NM_005955 | MTF1 4520 Hs.47199 205322_s 1 GO:00069 - AW18236 metal-regulatory transcription chr1:3827 38275238 38325292 -0.79138 -8.73857 -1.60849 0.184068 0.330516 200814_a NM_006263 | PSME1 5720 Hs.75348 200814_a 14 GO:00311 + NM_0062 proteasome (prosome, chr14:246 24605377 24608175 -2.54719 -8.7316 -1.50274 0.172103 0.35548 218888_s NM_018092 | NETO2 81831 Hs.44404 218888_s 16 GO:00160 - NM_0180 neuropilin (NRP) and tolloid chr16:471 47115441 47177908 0.913294 -8.69433 -2.77423 0.319084 0.148937 204701_s NM_004809 | STOML1 9399 Hs.19481 204701_s 15 GO:00081 - NM_0048 stomatin (EPB72)-like 1 chr15:742 74275560 74284635 -0.88196 -8.6746 -1.41894 0.163574 0.372553 212378_a NM_000819 | GART 2618 Hs.47364 212378_a 21 GO:00061 - NM_0008 phosphoribosylglycinamide chr21:348 34896315 34914464 0.077359 -8.65874 -1.3229 0.152782 0.398945 204780_s NM_000043 | FAS 355 Hs.24413 204780_s 10 GO:00071 + AA16475 Fas (TNF receptor superfamily, chr10:907 90750287 90775541 -0.86932 -8.6572 -3.69542 0.42686 0.075152 202760_s NM_007203 | PALM2- 445815 Hs.59190 202760_s 9 NA + NM_0072 PALM2-AKAP2 readthrough chr9:1125 1.13E+08 1.13E+08 -1.26061 -8.63086 -3.99443 0.462808 0.060541 202688_a NM_003810 | TNFSF10 8743 Hs.47827 202688_a 3 GO:00071 - NM_0038 tumor necrosis factor (ligand) chr3:1722 1.72E+08 1.72E+08 -1.28038 -8.62345 -3.89343 0.451493 0.072221 204166_a NM_001100122 SBNO2 22904 Hs.40870 204166_a 19 GO:00022 - NM_0149 strawberry notch homolog 2 chr19:110 1107633 1174282 -0.96844 -8.61744 -1.54801 0.179637 0.340173 216841_s NM_000636 | SOD2 6648 Hs.48704 216841_s 6 GO:00013 - X15132 superoxide dismutase 2, chr6:1601 1.6E+08 1.6E+08 0.629571 -8.58831 -3.23048 0.376149 0.109211 201749_a NM_001113347 ECE1 1889 Hs.19508 201749_a 1 GO:00016 - BF969352 endothelin converting enzyme chr1:2154 21543739 21672034 -1.62387 -8.58549 -1.39499 0.162482 0.377764 216565_x NA NA NA NA 216565_x NA NA NA AL121994 NA chrNA:-1-- -1 -1 0.59445 -8.56398 -2.0659 0.241232 0.235518 207030_s NM_001321 | CSRP2 1466 Hs.53090 207030_s 12 GO:00160 - NM_0013 cysteine and glycine-rich chr12:772 77252495 77272799 -0.5678 -8.56304 -1.86048 0.217268 0.273367 215222_x NM_012090 | MACF1 23499 Hs.47247 215222_x 1 GO:00017 + AK023406 microtubule-actin crosslinking chr1:3954 39547117 39952789 0.427924 -8.55185 -1.2415 0.145173 0.423897 ©202145_a 2016NM_001127213 American LY6E Medical4061 Hs.52190 Association.202145_a 8 GO:00017 All rights+ NM_0023 reserved.lymphocyte antigen 6 complex, chr8:1440 1.44E+08 1.44E+08 -1.45487 -8.53762 -2.39664 0.280715 0.194209

Downloaded From: https://jamanetwork.com/ on 09/30/2021 200836_s NM_001134364 MAP4 4134 Hs.51794 200836_s 3 GO:00070 - NM_0023 microtubule-associated protein chr3:4801 48014569 48130769 -2.49823 -8.04087 -1.64734 0.204871 0.318009 221485_a NM_004776 | B4GALT5 9334 Hs.37048 221485_a 20 GO:00059 - AL035683 UDP-Gal:betaGlcNAc beta 1,4- chr20:482 48249484 48330421 1.547856 -8.03173 -2.49957 0.311212 0.174189 202869_a NM_001032409 OAS1 4938 Hs.52476 202869_a 12 GO:00061 + NM_0168 2',5'-oligoadenylate synthetase chr12:113 1.13E+08 1.13E+08 -1.23184 -7.99457 -1.46615 0.183393 0.361867 204620_s NM_001126336 VCAN 1462 Hs.64380 204620_s 5 GO:00071 + NM_0043 versican chr5:8276 82767492 82878122 -0.89475 -7.98837 -4.19515 0.525157 0.049366 211367_s NM_001223 | CASP1 834 Hs.2490 211367_s 11 GO:00016 - U13699 caspase 1, apoptosis-related chr11:104 1.05E+08 1.05E+08 -0.04463 -7.98834 -1.73751 0.217506 0.299527 209636_a NM_001077493 NFKB2 4791 Hs.73090 209636_a 10 GO:00022 + BC002844 nuclear factor of kappa light chr10:104 1.04E+08 1.04E+08 -0.25162 -7.98133 -2.49029 0.312015 0.176817 217848_s NM_021129 | PPA1 5464 Hs.43740 217848_s 10 GO:00067 - NM_0211 pyrophosphatase (inorganic) 1 chr10:719 71962585 71993190 0.761176 -7.97873 -4.28382 0.536905 0.056835 221528_s NM_133171 | ELMO2 63916 Hs.21046 221528_s 20 GO:00069 - BC000143 engulfment and cell motility 2 chr20:449 44994689 45035271 1.567669 -7.95803 -2.07197 0.260362 0.236264 212657_s NM_000577 | IL1RN 3557 Hs.81134 212657_s 2 GO:00069 + U65590 interleukin 1 receptor chr2:1138 1.14E+08 1.14E+08 0.111364 -7.9559 -2.28734 0.287502 0.204051 212135_s NM_001001396 ATP2B4 493 Hs.34352 212135_s 1 GO:00081 + AW51768 ATPase, Ca++ transporting, chr1:2035 2.04E+08 2.04E+08 0.047114 -7.93628 -1.3522 0.170382 0.390023 201783_s NM_001145138 RELA 5970 Hs.50287 201783_s 11 GO:00018 - NM_0219 v-rel reticuloendotheliosis viral chr11:654 65421067 65430443 -1.60719 -7.93305 -1.21092 0.152643 0.430576 48531_at NM_001161527 TNIP2 79155 Hs.36855 48531_at 4 GO:00072 - AA52281 TNFAIP3 interacting protein 2 chr4:2743 2743386 2758103 2.810967 -7.92949 -1.98722 0.250611 0.250613 205214_a NM_004226 | STK17B 9262 Hs.88297 205214_a 2 GO:00069 - NM_0042 serine/threonine kinase 17b chr2:1969 1.97E+08 1.97E+08 -0.80612 -7.92451 -1.80893 0.22827 0.284848 204770_a NM_000544 | TAP2 6891 Hs.502 204770_a 6 GO:00064 - NM_0005 transporter 2, ATP-binding chr6:3279 32793187 32806547 -0.87095 -7.92437 -1.89786 0.239497 0.266866 209037_s NM_006795 | EHD1 10938 Hs.52377 209037_s 11 GO:00068 - AW18286 EH-domain containing 1 chr11:646 64620207 64646191 -0.32427 -7.89492 -2.7111 0.343399 0.148908 206467_x NA NA NA NA 206467_x NA NA NA NM_0038 NA chrNA:-1-- -1 -1 -0.63968 -7.85606 -2.48471 0.316279 0.177346 208782_a NM_007085 | FSTL1 11167 Hs.26951 208782_a 3 GO:00305 - BC000055 follistatin-like 1 chr3:1201 1.2E+08 1.2E+08 -0.35542 -7.85544 -1.82526 0.232356 0.27825 217738_a NM_005746 | NAMPT 10135 Hs.48961 217738_a 7 GO:00071 - BF575514 nicotinamide chr7:1058 1.06E+08 1.06E+08 0.74643 -7.82143 -1.9277 0.246463 0.258567 202284_s NM_000389 | CDKN1A 1026 Hs.37077 202284_s 6 GO:00000 + NM_0003 cyclin-dependent kinase chr6:3664 36646458 36655108 -1.40519 -7.82121 -1.53895 0.196767 0.347804 206173_x NM_002041 | GABPB1 2553 Hs.65435 206173_x 15 GO:00063 - NM_0020 GA binding protein chr15:505 50578078 50647605 -0.67718 -7.80277 -1.46917 0.188289 0.3576 218983_a NM_016546 | C1RL 51279 Hs.63173 218983_a 12 GO:00065 - NM_0165 complement component 1, r chr12:724 7247146 7261869 0.928737 -7.77464 -3.82845 0.492429 0.065101 205641_s NM_003789 | TRADD 8717 Hs.46099 205641_s 16 GO:00071 - NM_0037 TNFRSF1A-associated via death chr16:671 67188088 67193812 -0.74808 -7.76932 -1.68167 0.21645 0.31249 202644_s NM_006290 | TNFAIP3 7128 Hs.21160 202644_s 6 GO:00199 + NM_0062 tumor necrosis factor, alpha- chr6:1381 1.38E+08 1.38E+08 -1.29305 -7.74769 -2.09454 0.270344 0.238122 204440_a NM_001040280 CD83 9308 Hs.59513 204440_a 6 GO:00069 + NM_0042 CD83 molecule chr6:1411 14117864 14137146 -0.92388 -7.73794 -1.40152 0.181123 0.382111 212659_s NM_000577 | IL1RN 3557 Hs.81134 212659_s 2 GO:00069 + AW08335 interleukin 1 receptor chr2:1138 1.14E+08 1.14E+08 0.111588 -7.72662 -2.53808 0.328485 0.165925 208012_x NM_004509 | SP110 3431 Hs.14515 208012_x 2 GO:00444 - NM_0045 SP110 nuclear body protein chr2:2310 2.31E+08 2.31E+08 -0.44862 -7.71409 -2.05194 0.265999 0.242407 204720_s NM_014787 | DNAJC6 9829 Hs.64764 204720_s 1 GO:00068 + AV72963 DnaJ (Hsp40) homolog, chr1:6573 65730429 65881552 -0.87885 -7.68941 -3.18153 0.413754 0.104615 202800_a NM_001166695 SLC1A3 6507 Hs.48191 202800_a 5 GO:00015 + NM_0041 solute carrier family 1 (glial high chr5:3660 36606456 36609397 -1.24984 -7.68452 -2.38287 0.310087 0.188251 205207_a NM_000600 | IL6 3569 Hs.65445 205207_a 7 GO:00017 + NM_0006 interleukin 6 (interferon, beta chr7:2276 22766765 22771619 -0.8072 -7.68262 -2.82299 0.367452 0.139694 213982_s NM_001035230 RABGAP1 9910 Hs.58537 213982_s 1 GO:00323 + BG107203 RAB GTPase activating protein 1- chr1:1741 1.74E+08 1.75E+08 0.276267 -7.6609 -1.70779 0.222922 0.309873 202779_s NM_014501 | UBE2S 27338 Hs.39639 202779_s 19 GO:00199 - NM_0145 ubiquitin-conjugating enzyme chr19:559 55912649 55919325 -1.25528 -7.6377 -1.72514 0.225872 0.301462 201952_a NM_001627 | ALCAM 214 Hs.59129 201952_a 3 GO:00071 + AA15672 activated leukocyte cell chr3:1050 1.05E+08 1.05E+08 -1.52895 -7.63333 -2.24533 0.294148 0.205111 208296_x NM_001077654 TNFAIP8 25816 Hs.65627 208296_x 5 GO:00069 + NM_0143 tumor necrosis factor, alpha- chr5:1186 1.19E+08 1.19E+08 -0.41382 -7.62726 -1.04841 0.137456 0.481853 208788_a NM_021814 | ELOVL5 60481 Hs.52018 208788_a 6 GO:00066 - AL136939 ELOVL family member 5, chr6:5313 53132195 53213942 -0.35461 -7.62308 -1.3067 0.171413 0.402054 212960_a NM_015130 | TBC1D9 23158 Hs.48081 212960_a 4 GO:00323 - BE646554 TBC1 domain family, member 9 chr4:1415 1.42E+08 1.42E+08 0.150132 -7.60866 -1.21501 0.159688 0.431861 203433_a NM_006441 | MTHFS 10588 Hs.45904 203433_a 15 GO:00093 - NM_0064 5,10-methenyltetrahydrofolate chr15:801 80137319 80189370 -1.10583 -7.58803 -1.25868 0.165877 0.418329 218516_s NM_017813 | IMPAD1 54928 Hs.43868 218516_s 8 GO:00160 - NM_0178 inositol monophosphatase chr8:5787 57870490 57906427 0.854649 -7.58002 -1.252 0.165171 0.419258 209761_s NM_004509 | SP110 3431 Hs.14515 209761_s 2 GO:00444 - AA96919 SP110 nuclear body protein chr2:2310 2.31E+08 2.31E+08 -0.23577 -7.5553 -1.79525 0.237615 0.289623 203333_a NM_014970 | KIFAP3 22920 Hs.43344 203333_a 1 GO:00071 - NM_0149 kinesin-associated protein 3 chr1:1698 1.7E+08 1.7E+08 -1.12597 -7.54037 -1.26153 0.167304 0.416932 203045_a NM_004148 | NINJ1 4814 Hs.49445 203045_a 9 GO:00071 - NM_0041 ninjurin 1 chr9:9588 95883771 95896570 -1.19049 -7.52281 -1.30335 0.173253 0.403987 219357_a NM_004286 | GTPBP1 9567 Hs.27692 219357_a 22 GO:00071 + NM_0140 GTP binding protein 1 chr22:391 39101806 39129590 0.991119 -7.51961 -1.81727 0.24167 0.281981 215305_a NM_006206 | PDGFRA 5156 Hs.74615 215305_a 4 GO:00017 + H79306 platelet-derived growth factor chr4:5509 55095263 55164411 0.43824 -7.49409 -0.72657 0.096952 0.604349 205452_a NM_004855 | PIGB 9488 Hs.61281 205452_a 15 GO:00162 + NM_0048 phosphatidylinositol glycan chr15:556 55611132 55647845 -0.7735 -7.48757 -2.05991 0.275111 0.234218 203817_a NM_000857 | GUCY1B3 2983 Hs.77890 203817_a 4 GO:00061 + W93728 guanylate cyclase 1, soluble, chr4:1566 1.57E+08 1.57E+08 -1.02939 -7.47184 -2.64406 0.35387 0.156528 205041_s NA NA NA NA 205041_s NA NA NA NM_0006 NA chrNA:-1-- -1 -1 -0.83035 -7.47124 -3.89743 0.521658 0.059712 © 2016 American Medical Association. All rights reserved. 205692_s NM_001775 | CD38 952 Hs.47921 205692_s 4 GO:00081 + NM_0017 CD38 molecule chr4:1577 15779930 15850706 -0.7414 -7.46973 -3.91551 0.524183 0.074449

Downloaded From: https://jamanetwork.com/ on 09/30/2021 214453_s NM_006417 | IFI44 10561 Hs.82316 214453_s 1 GO:00096 + NM_0064 interferon-induced protein 44 chr1:7911 79115476 79129761 0.33443 -7.46497 -2.34764 0.314487 0.202437 206508_a NM_001252 | CD70 970 Hs.50149 206508_a 19 GO:00071 - NM_0012 CD70 molecule chr19:658 6585850 6591163 -0.63467 -7.46497 -0.85042 0.113921 0.553526 218943_s NM_014314 | DDX58 23586 Hs.19062 218943_s 9 GO:00022 - NM_0143 DEAD (Asp-Glu-Ala-Asp) box chr9:3245 32455300 32526322 0.922255 -7.43635 -2.60477 0.350275 0.158724 203024_s NM_020199 | C5orf15 56951 Hs.35517 203024_s 5 GO:00160 - NM_0201 chromosome 5 open reading chr5:1332 1.33E+08 1.33E+08 -1.1958 -7.43432 -1.4701 0.197745 0.359222 204279_a NM_002800 | PSMB9 5698 Hs.65458 204279_a 6 GO:00516 + NM_0028 proteasome (prosome, chr6:3282 32821937 32827626 -0.95016 -7.43404 -2.25019 0.302687 0.210204 201350_a NM_004475 | FLOT2 2319 Hs.51403 201350_a 17 GO:00071 - NM_0044 flotillin 2 chr17:272 27206357 27224715 -1.86781 -7.42706 -1.59405 0.214627 0.326897 205965_a NM_006399 | BATF 10538 Hs.50996 205965_a 14 GO:00063 + NM_0063 basic leucine zipper chr14:759 75988783 76013327 -0.70395 -7.4226 -1.79453 0.241766 0.291729 208751_a NM_003827 | NAPA 8775 Hs.12693 208751_a 19 GO:00161 - BC001165 N-ethylmaleimide-sensitive chr19:479 47990890 48018497 -0.359 -7.41899 -1.11198 0.149884 0.460789 214620_x NM_000919 | PAM 5066 Hs.36943 214620_x 5 GO:00551 + BF038548 peptidylglycine alpha- chr5:1022 1.02E+08 1.02E+08 0.354212 -7.40062 -1.66062 0.224389 0.314673 217977_a NM_016332 | SEPX1 51734 Hs.65534 217977_a 16 GO:00551 - NM_0163 selenoprotein X, 1 chr16:198 1988234 1993294 0.778777 -7.37769 -0.95653 0.129652 0.51361 220655_a NM_001128843 TNIP3 79931 Hs.20820 220655_a 4 NA - NM_0248 TNFAIP3 interacting protein 3 chr4:1220 1.22E+08 1.22E+08 1.267273 -7.36899 -3.41831 0.463877 0.087124 221487_s NM_004436 | ENSA 2029 Hs.63245 221487_s 1 GO:00068 - AF157510 endosulfine alpha chr1:1505 1.51E+08 1.51E+08 1.54899 -7.36526 -1.3694 0.185927 0.38352 209389_x NM_001079862 DBI 1622 Hs.78888 209389_x 2 GO:00068 + M15887 diazepam binding inhibitor chr2:1201 1.2E+08 1.2E+08 -0.2812 -7.34896 -1.15511 0.15718 0.446996 206560_s NM_006533 | MIA 8190 Hs.64636 206560_s 19 GO:00071 + NM_0065 melanoma inhibitory activity chr19:412 41281299 41283392 -0.62787 -7.3461 -1.23482 0.168091 0.422412 202659_a NM_002801 | PSMB10 5699 Hs.9661 202659_a 16 GO:00516 - NM_0028 proteasome (prosome, chr16:679 67968406 67970753 -1.28826 -7.28723 -1.34639 0.18476 0.396067 218792_s NM_017688 | BSPRY 54836 Hs.61451 218792_s 9 GO:00068 + NM_0176 B-box and SPRY domain chr9:1161 1.16E+08 1.16E+08 0.897741 -7.28432 -1.64815 0.226261 0.31738 219982_s NA NA NA NA 219982_s NA NA NA NM_0229 NA chrNA:-1-- -1 -1 1.110527 -7.28148 -1.41663 0.194552 0.375597 202042_a NM_002109 | HARS 3035 Hs.52805 202042_a 5 GO:00064 - NM_0021 histidyl-tRNA synthetase chr5:1400 1.4E+08 1.4E+08 -1.49295 -7.28119 -1.79414 0.246407 0.284138 207000_s NM_005605 | PPP3CC 5533 Hs.14941 207000_s 8 GO:00086 + NM_0056 protein phosphatase 3 chr8:2229 22298595 22398635 -0.57155 -7.2774 -2.23177 0.306672 0.208611 203153_a NM_001548 | IFIT1 3434 Hs.20315 203153_a 10 GO:00081 + NM_0015 interferon-induced protein chr10:911 91152321 91163742 -1.16492 -7.26797 -2.90272 0.399386 0.138994 212507_a NM_015348 | TMEM131 23505 Hs.46937 212507_a 2 GO:00081 - D87446 transmembrane protein 131 chr2:9837 98372802 98612354 0.093266 -7.26435 -1.39035 0.191394 0.383556 202734_a NM_004240 | TRIP10 9322 Hs.51509 202734_a 19 GO:00300 + NM_0042 thyroid chr19:673 6739706 6751528 -1.26807 -7.2495 -2.20451 0.304091 0.214608 219366_a NM_020371 | AVEN 57099 Hs.55596 219366_a 15 GO:00069 - NM_0203 apoptosis, caspase activation chr15:341 34158428 34331303 0.9927 -7.24904 -1.52173 0.209921 0.352409 31845_at NM_001127197 ELF4 2000 Hs.27194 31845_at X GO:00017 - U32645 E74-like factor 4 (ets domain chrX:1291 1.29E+08 1.29E+08 2.2135 -7.21251 -1.24692 0.172883 0.422425 203490_a NM_001127197 ELF4 2000 Hs.27194 203490_a X GO:00017 - NM_0014 E74-like factor 4 (ets domain chrX:1291 1.29E+08 1.29E+08 -1.09422 -7.20993 -1.11523 0.15468 0.463608 218424_s NM_001008410 STEAP3 55240 Hs.64782 218424_s 2 GO:00069 + NM_0182 STEAP family member 3 chr2:1199 1.2E+08 1.2E+08 0.841282 -7.20668 -2.05262 0.284821 0.23548 209556_a NM_001014839 NCDN 23154 Hs.12187 209556_a 1 GO:00454 + AB011179 neurochondrin chr1:3602 36023392 36032378 -0.26093 -7.20277 -1.40017 0.194394 0.380685 209445_x NM_018224 | C7orf44 55744 Hs.65516 209445_x 7 GO:00160 - AI765280 chromosome 7 open reading chr7:4367 43678858 43769083 -0.27447 -7.20066 -2.00792 0.278852 0.250291 201157_s NM_021079 | NMT1 4836 Hs.53279 201157_s 17 GO:00017 + AF020500 N-myristoyltransferase 1 chr17:431 43138679 43186380 -2.03699 -7.18427 -0.97308 0.135445 0.509078 205463_s NM_002607 | PDGFA 5154 Hs.53589 205463_s 7 GO:00015 - NM_0026 platelet-derived growth factor chr7:5368 536898 559481 -0.77204 -7.1831 -2.71973 0.378629 0.144821 209939_x NM_001127183 CFLAR 8837 Hs.39073 209939_x 2 GO:00065 + AF005775 CASP8 and FADD-like apoptosis chr2:2019 2.02E+08 2.02E+08 -0.21411 -7.17831 -2.15137 0.299705 0.228343 203143_s NM_001162893 KIAA0040 9674 Hs.51813 203143_s 1 NA - T79953 KIAA0040 chr1:1751 1.75E+08 1.75E+08 -1.1669 -7.16815 -1.94365 0.271151 0.255009 216080_s NM_021727 | FADS3 3995 Hs.21765 216080_s 11 GO:00229 - AC004770 fatty acid desaturase 3 chr11:616 61640998 61659006 0.533617 -7.16491 -0.85124 0.118806 0.554323 202716_a NM_002827 | PTPN1 5770 Hs.41754 202716_a 20 GO:00071 + NM_0028 protein tyrosine phosphatase, chr20:491 49126890 49201084 -1.27323 -7.16447 -1.52964 0.213504 0.348679 205476_a NM_001130046 CCL20 6364 Hs.75498 205476_a 2 GO:00427 + NM_0045 chemokine (C-C motif) ligand 20 chr2:2286 2.29E+08 2.29E+08 -0.77039 -7.11321 -2.75818 0.387755 0.145004 211571_s NM_001126336 VCAN 1462 Hs.64380 211571_s 5 GO:00071 + D32039 versican chr5:8276 82767492 82878122 -0.02048 -7.11296 -3.21056 0.451368 0.10127 206992_s NM_001003803 ATP5S 27109 Hs.43848 206992_s 14 GO:00067 + NM_0156 ATP synthase, H+ transporting, chr14:507 50779046 50789741 -0.57244 -7.10775 -0.94831 0.13342 0.518231 212059_s NM_015638 | TRPC4AP 26133 Hs.16807 212059_s 20 GO:00064 - AL117480 transient receptor potential chr20:335 33590214 33680618 0.037553 -7.09798 -0.958 0.134967 0.514958 219869_s NM_001135146 SLC39A8 64116 Hs.28803 219869_s 4 GO:00068 - NM_0221 solute carrier family 39 (zinc chr4:1031 1.03E+08 1.03E+08 1.08749 -7.09737 -1.23927 0.17461 0.421016 218214_a NM_001098673 C12orf44 60673 Hs.9911 218214_a 12 GO:00000 + NM_0219 chromosome 12 open reading chr12:524 52463757 52471278 0.811169 -7.09632 -0.79868 0.112548 0.573614 218556_a NM_014182 | ORMDL2 29095 Hs.53445 218556_a 12 GO:00160 + NM_0141 ORM1-like 2 (S. cerevisiae) chr12:562 56211805 56214959 0.860636 -7.08165 -1.38614 0.195737 0.381244 219716_a NM_030641 | APOL6 80830 Hs.25735 219716_a 22 GO:00068 + NM_0306 apolipoprotein L, 6 chr22:360 36044423 36064455 1.056881 -7.08078 -2.18911 0.309162 0.22061 210916_s NM_000610 | CD44 960 Hs.50232 210916_s 11 GO:00015 + AF098641 CD44 molecule (Indian blood chr11:351 35160416 35253946 -0.09687 -7.07377 -1.52425 0.215479 0.350755 202245_a NM_001001438 LSS 4047 Hs.59654 202245_a 21 GO:00066 - AW08451 lanosterol synthase (2,3- chr21:476 47609037 47648738 -1.41823 -7.07214 -1.64783 0.233003 0.314275 212379_a NM_000819 | GART 2618 Hs.47364 212379_a 21 GO:00061 - BE966876 phosphoribosylglycinamide chr21:348 34896315 34914464 0.077486 -7.06243 -0.9222 0.130578 0.527392 221578_a NM_032023 | RASSF4 83937 Hs.52289 221578_a 10 GO:00071 + AF260335 Ras association (RalGDS/AF-6) chr10:454 45455218 45490170 1.58994 -7.03977 -1.82165 0.258765 0.28587

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 206137_a NM_001100117 RIMS2 9699 Hs.65527 206137_a 8 GO:00068 + NM_0146 regulating synaptic membrane chr8:1045 1.05E+08 1.05E+08 -0.68179 -7.03064 -0.6435 0.091527 0.639738 204086_a NM_006115 | PRAME 23532 Hs.30743 204086_a 22 GO:00082 - NM_0061 preferentially expressed chr22:228 22890123 22901696 -0.98225 -7.0161 -2.66966 0.380504 0.14905 211144_x NA NA NA NA 211144_x NA NA NA M30894 NA chrNA:-1-- -1 -1 -0.06921 -7.01189 -1.40633 0.200563 0.37587 203110_a NM_004103 | PTK2B 2185 Hs.49132 203110_a 8 GO:00001 + U43522 PTK2B protein tyrosine kinase 2 chr8:2716 27168998 27316903 -1.1751 -7.01078 -1.54906 0.220954 0.342668 201885_s NM_000398 | CYB5R3 1727 Hs.70057 201885_s 22 GO:00551 - NM_0003 cytochrome b5 reductase 3 chr22:430 43013846 43045405 -1.55804 -6.98951 -1.06956 0.153024 0.474038 212656_a NM_005726 | TSFM 10102 Hs.63270 212656_a 12 GO:00064 + AF110399 Ts translation elongation factor, chr12:581 58176527 58191370 0.111221 -6.98682 -1.38356 0.198024 0.38612 220358_a NM_018664 | BATF3 55509 Hs.62919 220358_a 1 GO:00063 - NM_0186 basic leucine zipper chr1:2128 2.13E+08 2.13E+08 1.193286 -6.97321 -2.29528 0.329156 0.199835 222292_a NM_001250 | CD40 958 Hs.47286 222292_a 20 GO:00027 + AW29812 CD40 molecule, TNF receptor chr20:447 44746905 44758384 2.091489 -6.95974 -3.29707 0.473735 0.100683 221903_s NM_001042355 CYLD 1540 Hs.57897 221903_s 16 GO:00064 + BE046443 cylindromatosis (turban tumor chr16:507 50775960 50835846 1.766234 -6.94978 -1.26767 0.182405 0.414592 214446_a NM_012081 | ELL2 22936 Hs.19222 214446_a 5 GO:00063 - NM_0120 elongation factor, RNA chr5:9522 95220803 95297775 0.333456 -6.9103 -1.68548 0.243908 0.308198 203217_s NM_001042437 ST3GAL5 8869 Hs.41511 203217_s 2 GO:00015 - NM_0038 ST3 beta-galactoside alpha-2,3- chr2:8606 86066273 86094793 -1.15064 -6.91016 -1.26333 0.182822 0.413961 207978_s NM_006981 | NR4A3 8013 Hs.27952 207978_s 9 GO:00017 + NM_0069 nuclear receptor subfamily 4, chr9:1025 1.03E+08 1.03E+08 -0.45263 -6.90897 -2.37516 0.34378 0.184661 1729_at NM_003789 | TRADD 8717 Hs.46099 1729_at 16 GO:00071 - L41690 TNFRSF1A-associated via death chr16:671 67188088 67193812 -5.45138 -6.90885 -1.53732 0.222515 0.342483 204858_s NM_001113755 TYMP 1890 Hs.59221 204858_s 22 GO:00000 - NM_0019 thymidine phosphorylase chr22:509 50964183 50968514 -0.85756 -6.88683 -2.07364 0.301103 0.231039 205220_a NM_006018 | GPR109B 8843 Hs.45842 205220_a 12 GO:00071 - NM_0060 G protein-coupled receptor chr12:123 1.23E+08 1.23E+08 -0.80527 -6.87319 -1.28557 0.187041 0.410277 202510_s NM_006291 | TNFAIP2 7127 Hs.52560 202510_s 14 GO:00015 + NM_0062 tumor necrosis factor, alpha- chr14:103 1.04E+08 1.04E+08 -1.3328 -6.86962 -1.4116 0.205484 0.37843 217966_s NM_052966 | FAM129A 116496 Hs.51866 217966_s 1 GO:00019 - NM_0220 family with sequence similarity chr1:1847 1.85E+08 1.85E+08 0.777186 -6.86807 -2.8075 0.408775 0.150665 206027_a NM_002960 | S100A3 6274 Hs.55760 206027_a 1 GO:00055 - NM_0029 S100 calcium binding protein A3 chr1:1535 1.54E+08 1.54E+08 -0.69568 -6.85519 -2.42541 0.353805 0.177824 221779_a NM_033386 | MICALL1 85377 Hs.51761 221779_a 22 GO:00057 + BC001090 MICAL-like 1 chr22:383 38302345 38338025 1.691481 -6.84425 -1.42141 0.207679 0.37261 203097_s NM_014247 | RAPGEF2 9693 Hs.11391 203097_s 4 GO:00001 + NM_0142 Rap guanine nucleotide chr4:1601 1.6E+08 1.6E+08 -1.17858 -6.82183 -2.43687 0.357216 0.184661 209000_s NM_001098811 SEPT8 23176 Hs.52205 209000_s 5 GO:00070 - BC001329 septin 8 chr5:1320 1.32E+08 1.32E+08 -0.32882 -6.81705 -0.93723 0.137483 0.520535 203196_a NM_001105515 ABCC4 10257 Hs.50842 203196_a 13 GO:00068 - AI948503 ATP-binding cassette, sub- chr13:957 95748024 95953687 -1.15522 -6.78004 -2.14813 0.316832 0.218372 210926_a XM_001723159 POTEKP 440915 Hs.63126 210926_a NA GO:00055 NA AY014272 POTE ankyrin domain family, chrNA:-1-- -1 -1 -0.09573 -6.77341 -0.94597 0.13966 0.519495 200800_s NA NA NA NA 200800_s NA NA NA NM_0053 NA chrNA:-1-- -1 -1 -2.58232 -6.77288 -1.50948 0.22287 0.347058 209409_a NM_001001549 GRB10 2887 Hs.16406 209409_a 7 GO:00071 - D86962 growth factor receptor-bound chr7:5065 50657759 50861159 -0.2789 -6.76938 -2.33072 0.344303 0.195132 208392_x NM_004509 | SP110 3431 Hs.14515 208392_x 2 GO:00444 - NM_0045 SP110 nuclear body protein chr2:2310 2.31E+08 2.31E+08 -0.40272 -6.76633 -1.40656 0.207877 0.376155 213375_s NM_001079691 N4BP2L1 90634 Hs.16122 213375_s 13 NA - N80918 NEDD4 binding protein 2-like 1 chr13:329 32974860 33002315 0.201538 -6.7539 -1.31016 0.193986 0.403988 222067_x NM_021063 | HIST1H2B 3017 Hs.59179 222067_x 6 GO:00063 + AL353759 histone cluster 1, H2bd chr6:2615 26158348 26158869 1.884436 -6.7498 -1.12339 0.166433 0.461953 205807_s NM_001126337 TUFT1 7286 Hs.48992 205807_s 1 GO:00302 + NM_0201 tuftelin 1 chr1:1515 1.52E+08 1.52E+08 -0.72567 -6.74322 -2.41887 0.358711 0.179848 212810_s NM_001135581 SLC1A4 6509 Hs.65435 212810_s 2 GO:00068 + W72527 solute carrier family 1 chr2:6521 65215578 65250997 0.130882 -6.72715 -1.37531 0.204441 0.380946 212619_a NM_001130963 TMEM194 23306 Hs.59104 212619_a 12 GO:00081 - AW20521 transmembrane protein 194A chr12:574 57449426 57472574 0.106847 -6.71883 -1.27 0.189021 0.418714 221685_s NM_017785 | CCDC99 54908 Hs.36871 221685_s 5 GO:00001 + AF269167 coiled-coil domain containing chr5:1690 1.69E+08 1.69E+08 1.643039 -6.70319 -0.93088 0.138871 0.525972 221865_a NM_153045 | C9orf91 203197 Hs.52235 221865_a 9 GO:00160 + BF969986 open reading chr9:1173 1.17E+08 1.17E+08 1.743476 -6.67221 -1.51118 0.226488 0.350866 221260_s NM_030809 | CSRNP2 81566 Hs.52442 221260_s 12 GO:00069 - NM_0308 cysteine-serine-rich nuclear chr12:514 51454989 51477333 1.459626 -6.64035 -1.36401 0.205413 0.386267 212750_a NM_001172735 PPP1R16 26051 Hs.45719 212750_a 20 GO:00071 + AB020630 protein phosphatase 1, chr20:374 37434347 37551663 0.123358 -6.64021 -1.62559 0.24481 0.320277 209544_a NM_003821 | RIPK2 8767 Hs.10375 209544_a 8 GO:00071 + AF027706 receptor-interacting serine- chr8:9076 90769974 90803291 -0.26201 -6.61895 -0.96256 0.145425 0.513618 218847_a NM_001007225 IGF2BP2 10644 Hs.35354 218847_a 3 GO:00096 - NM_0065 insulin-like growth factor 2 chr3:1853 1.85E+08 1.86E+08 0.906872 -6.60724 -1.4796 0.223936 0.354635 208811_s NA NA NA NA 208811_s NA NA NA AF080569 NA chrNA:-1-- -1 -1 -0.3518 -6.60632 -1.23501 0.186943 0.421294

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 eTable 2. M1- and M2-polarization genes that are associated with disease-free survival of patients with uveal melanoma. NM_0011 PTPN18 26469 Hs.51639 213521_a 2 GO:00064 + AW57537 protein chr2:1311 1.31E+08 1.31E+08 0.37879 2.180036 0.296872 0.136178 1.205972 NM_0066 TCFL5 10732 Hs.12624 204849_a 20 GO:00063 - NM_0066 transcript chr20:614 61472467 61493115 -0.31611 2.185919 0.458086 0.209562 1.221857 NM_0011 TNIP2 79155 Hs.36855 48531_at 4 GO:00072 - AA52281 TNFAIP3 chr4:2743 2743386 2758103 1.607622 2.192175 0.404987 0.184742 1.242083 NM_0011 SCO2 9997 Hs.18090 205241_a 22 GO:00551 - NM_0051 SCO chr22:509 50961998 50964868 -0.26334 2.211864 0.460446 0.208171 1.291192 NM_0120 CD93 22918 Hs.97199 202878_s 20 GO:00069 - NM_0120 CD93 chr20:230 23059993 23066977 -0.60845 2.217084 0.56775 0.25608 1.275061 NM_0035 TPST1 8460 Hs.42119 204140_a 7 GO:00064 + NM_0035 tyrosylpr chr7:6567 65670258 65825437 -0.42263 2.224399 0.451012 0.202757 1.244822 NM_0148 CD302 9936 Hs.13001 203799_a 2 GO:00160 - NM_0148 CD302 chr2:1606 1.61E+08 1.61E+08 -0.47249 2.231807 0.588343 0.263617 1.330966 NM_0050 NDUFB8 4714 Hs.52321 201227_s 10 GO:00061 - NM_0050 NADH chr10:102 1.02E+08 1.02E+08 -1.10247 2.233295 0.643137 0.287977 1.269657 NM_0031 SORL1 6653 Hs.36859 212560_a 11 GO:00066 + AV72826 sortilin- chr11:121 1.21E+08 1.22E+08 0.278266 2.244129 0.769441 0.342869 0.994498 NM_0010 C22orf9 23313 Hs.59220 217118_s 22 GO:00055 - AK025608 chromos chr22:455 45588122 45636650 0.550518 2.251507 0.598201 0.265689 1.301113 NM_0011 CTSC 1075 Hs.12806 201487_a 11 GO:00065 - NM_0018 cathepsi chr11:880 88053981 88070941 -1.00205 2.254211 0.589952 0.261711 1.186899 NM_0010 GRB10 2887 Hs.16406 210999_s 7 GO:00071 - U66065 growth chr7:5065 50657759 50861159 0.136055 2.257628 0.42496 0.188233 1.327532 NM_0011 RASGRP3 25780 Hs.14367 205801_s 2 GO:00001 + NM_0153 RAS chr2:3366 33661415 33789797 -0.20974 2.258705 0.675962 0.29927 1.234309 NM_0003 STS 412 Hs.52257 203769_s X GO:00081 + NM_0003 steroid chrX:7137 7137471 7272680 -0.47942 2.27637 0.402835 0.176964 1.312164 NM_0010 CXCR4 7852 Hs.59341 217028_a 2 GO:00001 - AJ224869 chemoki chr2:1368 1.37E+08 1.37E+08 0.544903 2.277063 0.79271 0.348128 1.113697 NM_0122 SLC7A8 23428 Hs.59664 202752_x 14 GO:00065 - NM_0122 solute chr14:235 23594505 23652849 -0.63229 2.290565 0.612463 0.267385 1.360797 NM_0064 C6orf108 10591 Hs.10975 39817_s_ 6 GO:00081 - AF040105 chromos chr6:4319 43193368 43197211 1.498575 2.304228 0.48403 0.210062 1.3813 NM_0147 MTSS1 9788 Hs.33699 203037_s 8 GO:00300 - NM_0147 metastas chr8:1255 1.26E+08 1.26E+08 -0.5801 2.307406 0.741605 0.321402 1.522447 NM_0011 APLP2 334 Hs.37024 208248_x 11 GO:00019 + NM_0016 amyloid chr11:129 1.3E+08 1.3E+08 -0.09059 2.309835 0.538535 0.233149 1.209046 NM_0152 ESYT1 23344 Hs.63272 208858_s 12 GO:00160 + BC004998 extende chr12:565 56522053 56538452 -0.04504 2.319535 0.427506 0.184307 1.244259 NM_0050 NDUFA9 4704 Hs.75227 208969_a 12 GO:00061 + AF050641 NADH chr12:475 4758282 4796397 -0.03401 2.322996 0.467488 0.201244 1.261232 NM_0068 SERINC3 10955 Hs.27216 221472_a 20 GO:00069 - Z97053 serine chr20:431 43127900 43150726 1.045064 2.329557 0.420719 0.180601 1.258003 NM_0003 CYB5R3 1727 Hs.70057 201885_s 22 GO:00551 - NM_0003 cytochro chr22:430 43013846 43045405 -0.86808 2.338844 0.497573 0.212743 1.226173 NM_0068 GMPR 2766 Hs.48474 204187_a 6 GO:00551 + NM_0068 guanosin chr6:1623 16238810 16295778 -0.40802 2.339352 0.674831 0.288469 1.262928 NM_0010 HDAC5 10014 Hs.43878 202455_a 17 GO:00063 - NM_0054 histone chr17:421 42154120 42201014 -0.71215 2.342327 0.475512 0.203008 1.310623 NM_0011 MPZL1 9019 Hs.49391 210087_s 1 GO:00071 + AF095727 myelin chr1:1676 1.68E+08 1.68E+08 0.088548 2.344301 0.442366 0.188699 1.386208 NM_0122 SLC7A8 23428 Hs.59664 216092_s 14 GO:00065 - AL365347 solute chr14:235 23594505 23652849 0.518068 2.34759 0.599357 0.255307 1.350271 NM_0068 CKAP4 10970 Hs.74368 200999_s 12 GO:00160 - NM_0068 cytoskele chr12:106 1.07E+08 1.07E+08 -1.2498 2.348033 0.507015 0.215932 1.326419 NM_0220 LASS2 29956 Hs.71310 222212_s 1 GO:00063 - AK001105 LAG1 chr1:1509 1.51E+08 1.51E+08 1.253911 2.349787 0.529972 0.22554 1.328968 NM_0028 PSMB9 5698 Hs.65458 204279_a 6 GO:00516 + NM_0028 proteaso chr6:3282 32821937 32827626 -0.38568 2.353432 0.900229 0.382517 1.156324 NM_0011 STAU2 27067 Hs.56181 204226_a 8 GO:00068 - NM_0143 staufen, chr8:7446 74461843 74659943 -0.39518 2.368482 0.485893 0.205149 1.337751 NM_0026 PFKP 5214 Hs.26010 201037_a 10 GO:00060 + NM_0026 phosphof chr10:310 3109751 3178995 -1.2105 2.369039 0.565369 0.238649 1.206799 NM_0009 PTGS1 5742 Hs.20197 205128_x 9 GO:00015 + NM_0009 prostagla chr9:1251 1.25E+08 1.25E+08 -0.27684 2.37571 0.490459 0.206447 1.401825 NM_0010 IFFO1 25900 Hs.15243 36030_at 12 GO:00058 - AL080214 intermed chr12:664 6648694 6665229 1.387448 2.377185 0.453002 0.190562 1.26003 NM_0011 PNPLA6 10908 Hs.63186 203718_a 19 GO:00015 + NM_0067 patatin- chr19:759 7599037 7626653 -0.48271 2.379371 0.414271 0.17411 1.360984 NM_0023 MAN2A1 4124 Hs.43282 205105_a 5 GO:00081 + NM_0023 mannosi chr5:1090 1.09E+08 1.09E+08 -0.28131 2.400357 0.601843 0.250731 1.341745 NM_0001 GLA 2717 Hs.69089 214430_a X GO:00081 - NM_0001 galactosi chrX:1006 1.01E+08 1.01E+08 0.427135 2.401209 0.474666 0.197678 1.366769 NM_0064 GAS2L1 10634 Hs.32285 31874_at 22 GO:00070 + Y07846 growth chr22:297 29702996 29708774 1.322879 2.406502 0.470465 0.195497 1.402457 NM_0029 RNH1 6050 Hs.53068 206050_s 11 GO:00064 - NM_0029 ribonucle chr11:494 494511 507273 -0.1897 2.411649 0.515101 0.213588 1.312439 NM_0010 PAPSS2 9060 Hs.52449 203060_s 10 GO:00001 + AF074331 3'- chr10:894 89419475 89507460 -0.57433 2.41427 0.636258 0.263541 1.458869 NM_0008 GART 2618 Hs.47364 212379_a 21 GO:00061 - BE966876 phosphor chr21:348 34896315 34914464 0.263691 2.424566 0.445557 0.183768 1.301223 NM_0008 GART 2618 Hs.47364 212378_a 21 GO:00061 - NM_0008 phosphor chr21:348 34896315 34914464 0.262201 2.425022 0.453618 0.187057 1.258244 NA NA NA NA 215528_a NA NA NA AL049390 NA chrna:-1-- -1 -1 0.495874 2.439437 0.506898 0.207793 1.344996 NM_0072 XPOT 11260 Hs.85951 212160_a 12 GO:00064 + AI984005 exportin, chr12:647 64798232 64842461 0.224338 2.452004 0.558095 0.227608 1.315096 NM_0043 DAP 1611 Hs.75189 201095_a 5 GO:00069 - NM_0043 death- chr5:1067 10679342 10761387 -1.14729 2.452025 0.521781 0.212796 1.278941 NM_1940 CREB3L2 64764 Hs.72322 212345_s 7 GO:00069 - BE675139 cAMP chr7:1375 1.38E+08 1.38E+08 0.254805 2.468437 0.59864 0.242518 1.243356

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 NM_0011 ATP2A2 488 Hs.50675 212361_s 12 GO:00081 + AW19007 ATPase, chr12:110 1.11E+08 1.11E+08 0.26071 2.47021 0.581568 0.235433 1.196217 NM_0011 APLP2 334 Hs.37024 208704_x 11 GO:00019 + BC000373 amyloid chr11:129 1.3E+08 1.3E+08 -0.0588 2.47118 0.594658 0.240637 1.262822 NM_0011 LYN 4067 Hs.69915 202625_a 8 GO:00025 + AI356412 v-yes-1 chr8:5679 56792385 56923936 -0.67317 2.50026 0.629016 0.25158 1.345504 NM_0010 GRB10 2887 Hs.16406 209409_a 7 GO:00071 - D86962 growth chr7:5065 50657759 50861159 0.022906 2.512206 0.606067 0.241249 1.262529 NM_0001 SGSH 6448 Hs.31074 204293_a 17 GO:00060 - NM_0001 N- chr17:781 78183080 78194199 -0.38249 2.53142 0.359705 0.142096 1.286633 NM_0190 CPVL 54504 Hs.23338 208146_s 7 GO:00065 - NM_0313 carboxyp chr7:2903 29035248 29186153 -0.09193 2.536643 0.701158 0.276412 1.403034 NM_0210 NMT1 4836 Hs.53279 201157_s 17 GO:00017 + AF020500 N- chr17:431 43138679 43186380 -1.12642 2.5372 0.462909 0.182449 1.2715 NM_0203 ZMIZ1 57178 Hs.19311 212124_a 10 GO:00015 + AF070622 zinc chr10:808 80828791 81076285 0.21565 2.547108 0.569125 0.22344 1.258347 NM_0011 NUSAP1 51203 Hs.61509 218039_a 15 GO:00002 + NM_0163 nucleolar chr15:416 41624925 41673247 0.635792 2.547782 0.695794 0.273098 1.538205 NM_0005 HEXB 3074 Hs.69293 201944_a 5 GO:00015 + NM_0005 hexosam chr5:7398 73980968 74017111 -0.84836 2.554732 0.680399 0.266329 1.367006 NM_0011 SEPT9 10801 Hs.44093 41220_at 17 GO:00070 + AB023208 septin 9 chr17:752 75277491 75496676 1.529615 2.574267 0.57414 0.22303 1.294437 NM_0011 TTC28 23331 Hs.38785 215146_s 22 GO:00054 - AB028966 tetratrico chr22:283 28374003 29075853 0.476971 2.599268 0.490998 0.188899 1.311296 NM_0010 NCOR2 9612 Hs.13751 207760_s 12 GO:00105 - NM_0063 nuclear chr12:124 1.25E+08 1.25E+08 -0.11157 2.621442 0.637032 0.243008 1.435502 NM_0010 PAPSS2 9060 Hs.52449 203058_s 10 GO:00001 + AW29995 3'- chr10:894 89419475 89507460 -0.57636 2.622814 0.630383 0.240346 1.591106 NM_0011 KDELR2 11014 Hs.65455 200699_a 7 GO:00161 - BE962456 KDEL (Lys- chr7:6500 6500712 6523849 -1.49255 2.651388 0.585443 0.220806 1.338383 NM_0003 CDKN1A 1026 Hs.37077 202284_s 6 GO:00000 + NM_0003 cyclin- chr6:3664 36646458 36655108 -0.74435 2.658689 0.643015 0.241854 1.325728 NM_0011 SYNPO 11346 Hs.43522 202796_a 5 GO:00058 + NM_0072 synaptop chr5:1499 1.5E+08 1.5E+08 -0.62421 2.67522 0.540877 0.202181 1.370913 NM_0122 TRAM2 9697 Hs.52018 202368_s 6 GO:00150 - AI986461 transloca chr6:5236 52362201 52441862 -0.73021 2.677806 0.483915 0.180713 1.384604 NM_0011 ABCC4 10257 Hs.50842 203196_a 13 GO:00068 - AI948503 ATP- chr13:957 95748024 95953687 -0.54641 2.682804 0.612346 0.228249 1.401965 NM_0022 ISG20 3669 Hs.45926 204698_a 15 GO:00007 + NM_0022 interfero chr15:891 89182038 89198879 -0.34038 2.691191 0.814676 0.302719 1.722438 NA NA NA NA 202603_a NA NA NA N51370 NA chrna:-1-- -1 -1 -0.6837 2.715461 0.778742 0.286781 1.4085 NM_0010 MBP 4155 Hs.55171 210136_a 18 GO:00069 - AW07043 myelin chr18:747 74724739 74844774 0.091384 2.725875 0.829253 0.304215 1.543404 NM_0010 SCARB1 949 Hs.70921 201819_a 12 GO:00019 - NM_0055 scavenge chr12:125 1.25E+08 1.25E+08 -0.87959 2.747482 0.613494 0.223293 1.488666 NM_0011 MX1 4599 Hs.51730 202086_a 21 GO:00069 + NM_0024 myxoviru chr21:427 42792519 42831140 -0.80301 2.753923 0.811679 0.294735 1.886871 NM_0159 PIGT 51604 Hs.43738 217770_a 20 GO:00162 + NM_0159 phosphat chr20:440 44044723 44054884 0.583463 2.762406 0.48625 0.176024 1.374571 NM_0010 TPST2 8459 Hs.72318 204079_a 22 GO:00064 - NM_0035 tyrosylpr chr22:269 26921715 26986089 -0.43558 2.78615 0.571486 0.205117 1.401652 NM_0055 IFI35 3430 Hs.63225 209417_s 17 GO:00096 + BC001356 interfero chr17:411 41158768 41166475 0.024251 2.812256 0.700853 0.249214 1.345572 NM_0001 GUSB 2990 Hs.25523 202605_a 7 GO:00081 - NM_0001 glucuroni chr7:6542 65425674 65447301 -0.6815 2.856195 0.653191 0.228693 1.454865 NM_0041 WARS 7453 Hs.49759 200628_s 14 GO:00064 - M61715 tryptoph chr14:100 1.01E+08 1.01E+08 -1.6226 2.860587 0.971675 0.339677 1.306061 NM_0001 SGSH 6448 Hs.31074 35626_at 17 GO:00060 - U30894 N- chr17:781 78183080 78194199 1.358742 2.865209 0.602314 0.210216 1.462629 NM_0011 RIMS2 9699 Hs.65527 206137_a 8 GO:00068 + NM_0146 regulatin chr8:1045 1.05E+08 1.05E+08 -0.18681 2.895169 0.985628 0.340439 3.744405 NM_0027 PRKCA 5578 Hs.53170 215195_a 17 GO:00001 + AF035594 protein chr17:642 64298925 64806862 0.480303 2.971327 0.682048 0.229543 1.569008 NM_0003 TGFBI 7045 Hs.36939 201506_a 5 GO:00071 + NM_0003 transfor chr5:1353 1.35E+08 1.35E+08 -0.98728 2.979694 0.867123 0.291011 1.460873 NM_0011 ADCY9 115 Hs.39186 204497_a 16 GO:00061 - AB011092 adenylat chr16:401 4012652 4166186 -0.34955 3.005559 0.697721 0.232143 1.336327 NM_0005 TAP1 6890 Hs.35201 202307_s 6 GO:00069 - NM_0005 transport chr6:3281 32812986 32821748 -0.7396 3.017185 0.922088 0.305612 1.351356 NM_0010 PLOD3 8985 Hs.15335 202185_a 7 GO:00551 - NM_0010 procollag chr7:1008 1.01E+08 1.01E+08 -0.7777 3.01889 0.723671 0.239714 1.549477 NM_0023 LRPAP1 4043 Hs.53313 201186_a 4 GO:00064 - NM_0023 low chr4:3514 3514289 3534224 -1.11669 3.077448 0.606085 0.196944 1.436192 NM_0011 SLC38A6 145389 Hs.20073 214830_a 14 GO:00068 + AI537540 solute chr14:614 61447831 61519259 0.458336 3.091244 0.765282 0.247564 1.535926 NM_0011 ELF4 2000 Hs.27194 31845_at X GO:00017 - U32645 E74-like chrX:1291 1.29E+08 1.29E+08 1.314676 3.107649 0.648977 0.208832 1.501755 NM_0153 LY96 23643 Hs.66076 206584_a 8 GO:00069 + NM_0153 lymphoc chr8:7490 74903586 74941305 -0.15391 3.249347 1.454542 0.447641 2.179211 NM_0033 PHLDA2 7262 Hs.15403 209803_s 11 GO:00069 - AF001294 pleckstri chr11:294 2949502 2950650 0.063801 3.337101 1.016902 0.304726 1.631636 NM_0159 CALHM2 51063 Hs.24154 221565_s 10 GO:00160 - BC000039 calcium chr10:105 1.05E+08 1.05E+08 1.097538 3.348496 0.663535 0.198159 1.498695 NM_0142 PTPLA 9200 Hs.11406 219654_a 10 GO:00071 - NM_0142 protein chr10:176 17631959 17659373 0.888958 3.368935 0.957496 0.284213 1.589796 NM_0010 MAD1L1 8379 Hs.65483 204857_a 7 GO:00000 - NM_0035 MAD1 chr7:1855 1855427 2272583 -0.31454 3.384135 0.955864 0.282454 2.122864 NM_0002 SGCB 6443 Hs.43895 205120_s 4 GO:00070 - U29586 sarcoglyc chr4:5288 52886860 52904485 -0.27979 3.429205 0.752936 0.219566 1.629577 NM_0024 MGST2 4258 Hs.81874 204168_a 4 GO:00071 + NM_0024 microso chr4:1405 1.41E+08 1.41E+08 -0.40961 3.487579 0.811988 0.232823 1.539432

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Downloaded From: https://jamanetwork.com/ on 09/30/2021 NM_0032 TIMP2 7077 Hs.63351 203167_a 17 GO:00082 - NM_0032 TIMP chr17:768 76849062 76921472 -0.55206 3.488238 0.838274 0.240314 1.69128 NA NA NA NA 212098_a NA NA NA AL134724 NA chrna:-1-- -1 -1 0.212738 3.544487 0.852174 0.240422 1.507342 NM_0011 LY6E 4061 Hs.52190 202145_a 8 GO:00017 + NM_0023 lymphoc chr8:1440 1.44E+08 1.44E+08 -0.78535 3.552763 0.852628 0.23999 1.585728 NM_0309 SFXN3 81855 Hs.28384 220974_x 10 GO:00068 + NM_0309 siderofle chr10:102 1.03E+08 1.03E+08 0.979529 3.634364 0.660118 0.181632 1.497673 NM_1788 MTDH 92140 Hs.37715 212248_a 8 GO:00001 + AI886796 metadhe chr8:9865 98656406 98742487 0.241695 3.728466 0.96182 0.257967 1.760886 NM_0041 WARS 7453 Hs.49759 200629_a 14 GO:00064 - NM_0041 tryptoph chr14:100 1.01E+08 1.01E+08 -1.59983 3.850212 1.24435 0.32319 1.724848 NM_0011 SLC1A4 6509 Hs.65435 209610_s 2 GO:00068 + BF340083 solute chr2:6521 65215578 65250997 0.049689 4.063903 1.259919 0.310027 2.226551 NM_0159 CALHM2 51063 Hs.24154 57715_at 10 GO:00160 - W72694 calcium chr10:105 1.05E+08 1.05E+08 1.752088 4.181529 0.788969 0.188679 1.695585 NM_0011 SLC1A4 6509 Hs.65435 212810_s 2 GO:00068 + W72527 solute chr2:6521 65215578 65250997 0.309697 4.219866 1.171604 0.27764 2.234108

NM_0011 SATB1 6304 Hs.51771 203408_s 3 GO:00001 - NM_0029 SATB chr3:1838 18389265 18480252 -0.51409 -3.56398 -0.93287 0.261749 0.497503

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