Supplementary Online Content Amaro A, Parodi F, Diedrich K, et al. Analysis of the expression and single-nucleotide variant frequencies of the buyrophilin-like 2 gene in patients with uveal melanoma. JAMA Ophthalmol. Published online August 11, 2016. doi: 10.1001/jamaophthalmol.2016.2691. eTable 1. M1- and M2-poloarization genes eTable 2. M1- and M2-polarization genes that are associated with disease-free survival of patients with uveal melanoma This supplementary material has been provided by the authors to give readers additional information about their work. © 2016 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/30/2021 eTable 1. M1- and M2-poloarization genes 203308_x NM_000195 | HPS1 3257 Hs.40456 203308_x 10 GO:00070 - AI185798 Hermansky-Pudlak syndrome 1 chr10:100 1E+08 1E+08 -1.13131 6.095084 0.859709 0.14105 1.819564 205022_s NM_001085471 FOXN3 1112 Hs.43428 205022_s 14 GO:00000 - NM_0051 forkhead box N3 chr14:896 89622516 90085494 -0.83339 6.106332 1.983495 0.324826 3.850649 204226_a NM_001164380 STAU2 27067 Hs.56181 204226_a 8 GO:00068 - NM_0143 staufen, RNA binding protein, chr8:7446 74461843 74659943 -0.95841 6.106973 0.850648 0.139291 1.804766 208639_x NM_005742 | PDIA6 10130 Hs.21210 208639_x 2 GO:00064 - BC001312 protein disulfide isomerase chr2:1092 10923518 10952960 -0.37258 6.110976 1.043652 0.170783 2.061971 204295_a NA NA NA NA 204295_a NA NA NA NM_0031 NA chrNA:-1-- -1 -1 -0.94773 6.113623 0.686679 0.112319 1.613194 202609_a NM_004447 | EPS8 2059 Hs.59116 202609_a 12 GO:00071 - NM_0044 epidermal growth factor chr12:157 15773075 15942510 -1.30353 6.122138 3.44239 0.562286 10.58922 204290_s NM_005589 | ALDH6A1 4329 Hs.29397 204290_s 14 GO:00551 - NM_0055 aldehyde dehydrogenase 6 chr14:745 74526873 74551196 -0.94848 6.123863 1.719006 0.280706 3.370511 212804_s NM_015635 | GAPVD1 26130 Hs.49513 212804_s 9 GO:00071 + AI797397 GTPase activating protein and chr9:1280 1.28E+08 1.28E+08 0.130083 6.123958 0.852913 0.139275 1.799541 52940_at NA NA NA NA 52940_at NA NA NA AA08576 NA chrNA:-1-- -1 -1 2.969083 6.124078 1.110866 0.181393 2.155788 41047_at NM_024112 | C9orf16 79095 Hs.52241 41047_at 9 GO:00081 + AI885170 chromosome 9 open reading chr9:1309 1.31E+08 1.31E+08 2.627325 6.128819 1.1017 0.179757 2.141424 217886_a NM_001159969 EPS15 2060 Hs.83722 217886_a 1 GO:00071 - BF213575 epidermal growth factor chr1:5181 51819934 51984995 0.766401 6.129662 0.871296 0.142144 1.838149 209083_a NM_007074 | CORO1A 11151 Hs.41506 209083_a 16 GO:00018 + U34690 coronin, actin binding protein, chr16:301 30194925 30200396 -0.31881 6.130288 1.479329 0.241315 2.808291 204487_s NM_000218 | KCNQ1 3784 Hs.95162 204487_s 11 GO:00069 + NM_0002 potassium voltage-gated chr11:246 2466220 2870339 -0.91602 6.135376 1.733615 0.282561 3.243998 218124_a NM_017750 | RETSAT 54884 Hs.44040 218124_a 2 GO:00551 - NM_0177 retinol saturase (all-trans- chr2:8556 85569078 85581821 0.798797 6.136715 1.058639 0.172509 2.091179 200652_a NM_003145 | SSR2 6746 Hs.74564 200652_a 1 GO:00066 - NM_0031 signal sequence receptor, beta chr1:1559 1.56E+08 1.56E+08 -3.04633 6.142696 0.660982 0.107605 1.58265 212640_a NM_198402 | PTPLB 201562 Hs.70548 212640_a 3 GO:00160 - AV71260 protein tyrosine phosphatase- chr3:1232 1.23E+08 1.23E+08 0.109175 6.146216 2.715988 0.441896 6.180602 200926_a NM_001025 | RPS23 6228 Hs.52719 200926_a 5 GO:00064 - NM_0010 ribosomal protein S23 chr5:8156 81569140 81574235 -2.33082 6.147136 0.584687 0.095115 1.498846 211329_x NM_000410 | HFE 3077 Hs.23332 211329_x 6 GO:00024 + AF115264 hemochromatosis chr6:2608 26087508 26095469 -0.04912 6.147206 1.059956 0.172429 2.084085 204950_a NM_014959 | CARD8 22900 Hs.44614 204950_a 19 GO:00429 - NM_0149 caspase recruitment domain chr19:487 48711343 48752925 -0.84366 6.152741 1.905161 0.309644 3.846062 202185_a NM_001084 | PLOD3 8985 Hs.15335 202185_a 7 GO:00551 - NM_0010 procollagen-lysine, 2- chr7:1008 1.01E+08 1.01E+08 -1.43903 6.156429 1.023681 0.166278 2.024901 221879_a NM_001031733 CALML4 91860 Hs.70955 221879_a 15 GO:00055 - AA88633 calmodulin-like 4 chr15:684 68483043 68498448 1.751208 6.157943 1.824663 0.29631 3.481771 214221_a NM_015120 | ALMS1 7840 Hs.18472 214221_a 2 GO:00069 + AI825212 Alstrom syndrome 1 chr2:7361 73612885 73837046 0.306488 6.158164 0.682931 0.110899 1.603871 213103_a NM_052851 | STARD13 90627 Hs.50770 213103_a 13 GO:00071 - AA12802 StAR-related lipid transfer chr13:336 33677272 33859901 0.1677 6.164741 1.521691 0.246838 2.881072 209240_a NM_181672 | OGT 8473 Hs.40541 209240_a X GO:00071 + AF070560 O-linked N-acetylglucosamine chrX:7075 70752911 70795747 -0.29981 6.169447 1.209091 0.19598 2.323459 65630_at NM_001042463 TMEM80 283232 Hs.44866 65630_at 11 GO:00160 + AI742455 transmembrane protein 80 chr11:695 695615 704127 3.554588 6.169681 1.490491 0.241583 2.859872 202316_x NM_001105562 UBE4B 10277 Hs.59397 202316_x 1 GO:00002 + AW24171 ubiquitination factor E4B (UFD2 chr1:1009 10093015 10241294 -1.3948 6.170145 1.253303 0.203124 2.369068 206492_a NM_001166243 FHIT 2272 Hs.65599 206492_a 3 GO:00062 - NM_0020 fragile histidine triad gene chr3:5973 59735037 61237133 -0.63671 6.171241 0.715333 0.115914 1.63816 201347_x NM_012203 | GRHPR 9380 Hs.15574 201347_x 9 GO:00551 + NM_0122 glyoxylate chr9:3742 37422706 37436986 -1.87051 6.174938 0.841456 0.13627 1.788451 211668_s NM_001145031 PLAU 5328 Hs.77274 211668_s 10 GO:00015 + K03226 plasminogen activator, chr10:756 75670861 75677256 -0.00818 6.187258 2.016798 0.32596 4.101064 200598_s NM_003299 | HSP90B1 7184 Hs.19237 200598_s 12 GO:00016 + AI582238 heat shock protein 90kDa beta chr12:104 1.04E+08 1.04E+08 -3.37115 6.194171 1.660065 0.268004 3.093477 202605_a NM_000181 | GUSB 2990 Hs.25523 202605_a 7 GO:00081 - NM_0001 glucuronidase, beta chr7:6542 65425674 65447301 -1.30482 6.19799 1.50091 0.242161 2.826573 202665_s NM_001077269 WIPF1 7456 Hs.12806 202665_s 2 GO:00300 - NM_0033 WAS/WASL interacting protein chr2:1754 1.75E+08 1.76E+08 -1.28676 6.206483 0.796574 0.128345 1.743269 221194_s NM_016125 | RNFT1 51136 Hs.53170 221194_s 17 GO:00160 - NM_0161 ring finger protein, chr17:580 58029723 58042117 1.434372 6.207411 1.056306 0.170169 2.067375 203332_s NM_001017915 INPP5D 3635 Hs.26288 203332_s 2 GO:00067 + NM_0055 inositol polyphosphate-5- chr2:2339 2.34E+08 2.34E+08 -1.12618 6.211592 1.264531 0.203576 2.383988 203959_s NM_001083621 ZBTB40 9923 Hs.41896 203959_s 1 GO:00454 + NM_0148 zinc finger and BTB domain chr1:2277 22778343 22857650 -1.00454 6.21406 0.940932 0.15142 1.92485 222200_s NM_001143888 BSDC1 55108 Hs.35345 222200_s 1 NA - AK021440 BSD domain containing 1 chr1:3283 32830706 32860062 1.997938 6.214454 0.715455 0.115128 1.641197 214264_s NM_145231 | C14orf14 90141 Hs.12323 214264_s 14 GO:00055 - AI656610 chromosome 14 open reading chr14:902 90263470 90421089 0.311507 6.221441 0.894347 0.143752 1.855304 208033_s NM_001164766 ZFHX3 463 Hs.59829 208033_s 16 GO:00001 - NM_0068 zinc finger homeobox 3 chr16:728 72816787 73092534 -0.44621 6.222348 1.580732 0.254041 3.044483 215440_s NM_001080425 BEX4 56271 Hs.18473 215440_s X GO:00056 + AL523320 brain expressed, X-linked 4 chrX:1024 1.02E+08 1.02E+08 0.454995 6.225579 1.103029 0.177177 2.160216 210872_x NM_001130831 GAS7 8522 Hs.46221 210872_x 17 GO:00510 - BC001152 growth arrest-specific 7 chr17:981 9813925 10101868 -0.10121 6.228061 2.069179 0.332235 4.327868 214873_a NM_001135772 LRP5L 91355 Hs.63405 214873_a 22 GO:00160 - AL137651 low density lipoprotein chr22:257 25747385 25777544 0.384872 6.228202 0.687182 0.110334 1.606742 202164_s NM_004779 | CNOT8 9337 Hs.26703 202164_s 5 GO:00063 + AF180476 CCR4-NOT transcription chr5:1542 1.54E+08 1.54E+08 -1.44737 6.228693 1.453202 0.233308 2.695546 203357_s NM_014296 | CAPN7 23473 Hs.59523 203357_s 3 GO:00065 + NM_0142 calpain 7 chr3:1524 15247732 15294422 -1.12137 6.239099 1.577948 0.252913 2.987047 221036_s NM_001145646 APH1B 83464 Hs.51170 221036_s 15 GO:00069 + NM_0313 anterior pharynx defective 1 chr15:635 63569748 63601324 1.381998 6.240169 0.727292 0.11655 1.658962 201365_a NM_002537 | OAZ2 4947 Hs.74563 201365_a 15 GO:00065 - NM_0025 ornithine decarboxylase chr15:649 64979772 64995462 -1.85679 6.24722 0.844551 0.135188 1.791604 212248_a NM_178812 | MTDH 92140 Hs.37715 212248_a 8 GO:00001 + AI886796 metadherin chr8:9865 98656406 98742487 0.06131 6.250295 1.72747 0.276382 3.253897 © 2016 American Medical Association. 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Downloaded From: https://jamanetwork.com/ on 09/30/2021 203613_s NM_002493 | NDUFB6 4712 Hs.49366 203613_s 9 GO:00061 - NM_0024 NADH dehydrogenase chr9:3255 32553522 32573182 -1.0699 6.252187 0.771374 0.123377 1.703633 202455_a NM_001015053 HDAC5 10014 Hs.43878 202455_a 17 GO:00063 - NM_0054 histone deacetylase 5 chr17:421 42154120 42201014 -1.35005 6.257979 1.852768 0.296065 3.608243 204392_a NM_003656 | CAMK1 8536 Hs.43487 204392_a 3 GO:00071 - NM_0036 calcium/calmodulin-dependent chr3:9799 9799032 9811661 -0.93179 6.258085 2.536383 0.405297 5.586291 202386_s NM_014647 | KIAA0430 9665 Hs.17352 202386_s 16 GO:00057 - NM_0190 KIAA0430 chr16:156 15688244 15737009 -1.37221 6.260295 1.422592 0.22724 2.698285 55616_at NM_033419 | PGAP3 93210 Hs.46297 55616_at 17 GO:00065 - AI703342 post-GPI attachment to proteins chr17:378 37827375 37844310 3.046334 6.261788 0.64587 0.103145 1.564355 211105_s NM_006162 | NFATC1 4772 Hs.53407 211105_s 18 GO:00063 + U80918 nuclear factor of activated T- chr18:771 77155771 77228177 -0.07372 6.265355 1.238266 0.197637 2.369657 218041_x NM_018976 | SLC38A2 54407 Hs.22184 218041_x 12 GO:00068 - NM_0185