DOCSLIB.ORG

Diphenhydramine(BAN, Rinn)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Diphenhydramine(BAN, Rinn) Desloratadine/Diphenhydramine 577 Pharmacopoeias. In Eur. (see p.vii). Diphenhydramine Citrate (BANM, rINNM) There have been reports3,4 of rhabdomyolysis as an effect of oral Ph. Eur. 6.2 (Dimetindene Maleate). A white to almost white, Benzhydramine Citrate; Citrato de difenhidramina; Diphénhy- diphenhydramine overdosage. The liberal application of a lotion crystalline powder. Slightly soluble in water; soluble in methyl containing diphenhydramine produced acute delirium with visu- dramine, Citrate de; Diphenhydramini Citras. alcohol. Protect from light. al and auditory hallucinations in a 9-year-old boy5 and similar Дифенгидрамина Цитрат Profile effects were seen in 3 children with varicella-zoster infection fol- C17H21NO,C6H8O7 = 447.5. lowing the topical application of diphenhydramine (2 of these Dimetindene maleate, an alkylamine derivative, is a sedating an- CAS — 88637-37-0. children also received oral diphenhydramine).6 tihistamine (p.561); it is mildly sedative and is reported to have ATC — D04AA32; R06AA02. 1. Köppel C, Tenczer J. Clinical symptomatology of diphenhy- mast-cell stabilising properties. It is used for the symptomatic re- ATC Vet — QD04AA32; QR06AA02. dramine overdose: an evaluation of 136 cases in 1982 to 1985. lief of allergic conditions including urticaria and angioedema Pharmacopoeias. In US. Clin Toxicol 1987; 25: 53–70. (p.565) and rhinitis (p.565), and in pruritic skin disorders (p.565). USP 31 (Diphenhydramine Citrate). Store in airtight containers. 2. Radovanovic D, et al. Dose-dependent toxicity of diphenhy- It is also used in compound preparations for the symptomatic dramine overdose. Hum Exp Toxicol 2000; 19: 489–95. Protect from light. treatment of coughs and the common cold (p.564). 3. Hampel G, et al. Myoglobinuric renal failure due to drug-in- duced rhabdomyolysis. Hum Toxicol 1983; 2: 197–203. Dimetindene maleate is given in an oral dose of 1 to 2 mg three Diphenhydramine Di(acefyllinate) (rINNM) 4. Haas CE, et al. Rhabdomyolysis and acute renal failure follow- times daily; modified-release preparations are also available. It ing an ethanol and diphenhydramine overdose. Ann Pharmaco- may also be given by the intravenous route. Dimetindene Benzhydramine Di(acefyllinate); Bietanautine; Di(acefilinato) de ther 2003; 37: 538–42. maleate is applied topically as a 0.1% gel or lotion although, as difenhidramina; Diphénhydramine Diacéfylline; Diphenhy- 5. Filloux F. Toxic encephalopathy caused by topically applied with other antihistamines, there is a risk of sensitisation. It is used dramine Di(acephyllinate); Diphenhydramini Diacefyllinas. diphenhydramine. J Pediatr 1986; 108: 1018–20. 6. Chan CYJ, Wallander KA. Diphenhydramine toxicity in three in a strength of 0.025% in compound nasal preparations. Diphenhydramine bis(theophyllin-7-ylacetate). children with varicella-zoster infection. DICP Ann Pharmacoth- Preparations Дифенгидрамина Диацефиллинат er 1991; 25: 130–2. Proprietary Preparations (details are given in Part 3) C17H21NO,2C9H10N4O4 = 731.8. Porphyria. Diphenhydramine has been associated with acute Austria: Fenistil; Belg.: Fenistil; Cz.: Fenistil; Ger.: Fenistil; Gr.: Fenistil; CAS — 6888-11-5. attacks of porphyria and is considered unsafe in porphyric pa- Hung.: Fenistil; India: Foristal; Indon.: Fenistil; Israel: Fenistil; Ital.: Fenistil; ATC — D04AA32; R06AA02. tients. Neth.: Fenistil; Norw.: Fenistil†; Philipp.: Fenistil; Pol.: Fenistil; Port.: Fen- ATC Vet — QD04AA32; QR06AA02. istil; Neostil; Rus.: Fenistil (Фенистил); Spain: Fenistil; Switz.: Fenistil; Pregnancy. A pregnant woman who was receiving diphenhy- Thai.: Fenistil; Turk.: Fenistil; Venez.: Fenistil†. NOTE. The name Etanautine has been applied both to diphenhy- dramine hydrochloride 150 mg daily for a pruritic rash gave birth Multi-ingredient: Arg.: Vibragel; Austria: Trimedil; Vibrocil; Belg.: Vi- dramine monoacefyllinate and to ethylbenzhydramine, an an- to an infant who developed diarrhoea and generalised tremulous- brocil; Braz.: Gripen; Trimedal; Cz.: Vibrocil; Ger.: Vibrocil†; Gr.: Vibrocil- timuscarinic formerly used in the symptomatic treatment of par- ness 5 days later.1 The delay in appearance of withdrawal symp- S; Hong Kong: Vibrocil†; Hung.: Otrivin Allergia; Vibrocil; Israel: Vibrocil; kinsonism. Ital.: Vibrocil; Pol.: Otrivin Allergy; Port.: Vibrocil; Rus.: Vibrocil toms was considered to be due to reduced activity of glucuronyl (Виброцил); S.Afr.: Vibrocil; Vibrocil-S; Switz.: Vibrocil. conjugating enzymes in the first few days of life. Diphenhydramine Hydrochloride (BANM, rINNM) For discussion of the use of antihistamines in pregnancy, includ- Benzhydramine Hydrochloride; Difenhidramin Hidroklorür; ing a suggestion of a relationship between inguinal hernia or gen- Difenhidramin-hidroklorid; Difenhidramino hidrochloridas; ito-urinary malformations and diphenhydramine exposure, see Dimetotiazine Mesilate (BANM, rINNM) Difenhydramiinihydrokloridi; Difenhydramin-hydrochlorid; Difen- p.563. See also under Interactions, below, for a report of perinatal Dimethothiazine Mesylate; Dimétotiazine, Mésilate de; Dimeto- hydraminhydroklorid; Difenhydraminy chlorowodorek; Dime- death possibly associated with temazepam and diphenhy- tiazini Mesilas; Fonazine Mesylate (USAN); IL-6302 (dimetotiazine); drolum; Diphénhydramine, chlorhydrate de; Diphenhydramini dramine. Mesilato de dimetotiazina; 8599-RP (dimetotiazine). 10-(2- hydrochloridum; Diphenhydraminium Chloride; Hidrocloruro 1. Parkin DE. Probable Benadryl withdrawal manifestations in a new-born infant. J Pediatr 1974; 85: 580. Dimethylaminopropyl)-NN-dimethylphenothiazine-2-sulphona- de difenhidramina. mide methanesulphonate. Дифенгидрамина Гидрохлорид Interactions Диметотиазина Мезилат C17H21NO,HCl = 291.8. As for the sedating antihistamines in general, p.563. C19H25N3O2S2,CH3SO3H = 487.7. CAS — 147-24-0. CAS — 7456-24-8 (dimetotiazine); 7455-39-2 (dimeto- ATC — D04AA32; R06AA02. Diphenhydramine inhibits the cytochrome P450 isoen- tiazine mesilate). ATC Vet — QD04AA32; QR06AA02. zyme CYP2D6 that is partly responsible for the metab- ATC — N02CX05. Pharmacopoeias. In Chin., Eur. (see p.vii), Jpn, and US. olism of some beta blockers including metoprolol and ATC Vet — QN02CX05. Jpn also includes Diphenhydramine Tannate. the antidepressant venlafaxine. Ph. Eur. 6.2 (Diphenhydramine Hydrochloride). A white or al- 1 most white, crystalline powder. Very soluble in water; freely sol- Benzodiazepines. There has been a report suggesting that a H3C CH3 uble in alcohol. A 5% solution in water has a pH of 4.0 to 6.0. reduction in temazepam metabolism caused by diphenhy- N Protect from light. dramine may have contributed to perinatal death after ingestion USP 31 (Diphenhydramine Hydrochloride). A white, odourless, of these drugs by the mother. O O crystalline powder. It slowly darkens on exposure to light. Solu- 1. Kargas GA, et al. Perinatal mortality due to interaction of CH3 diphenhydramine and temazepam. N Engl J Med 1985; 313: ble 1 in 1 of water, 1 in 2 of alcohol and of chloroform, and 1 in 1417–18. N S CH3 50 of acetone; very slightly soluble in ether and in benzene. Its N solutions are neutral to litmus. Store in airtight containers. Pro- Pharmacokinetics tect from light. Diphenhydramine hydrochloride is well absorbed CH S 3 Incompatibility. Diphenhydramine hydrochloride has been re- from the gastrointestinal tract, although high first-pass ported to be incompatible with amphotericin B, cefmetazole so- (dimetotiazine) dium, cefalotin sodium, hydrocortisone sodium succinate, some metabolism appears to affect systemic availability. soluble barbiturates, some contrast media, and solutions of alka- Peak plasma concentrations are achieved about 1 to 4 Profile lis or strong acids. hours after oral doses. Diphenhydramine is widely dis- Dimetotiazine mesilate, a phenothiazine derivative, is a sedating tributed throughout the body including the CNS. It antihistamine (p.561). It has been used for the symptomatic relief Adverse Effects and Precautions crosses the placenta and has been detected in breast of hypersensitivity reactions, in pruritic skin disorders, and in the As for the sedating antihistamines in general, p.561. management of headaches including migraine. milk. Diphenhydramine is highly bound to plasma pro- Abuse. Reports of the abuse of diphenhydramine hydrochlo- teins. Metabolism is extensive. Diphenhydramine is Preparations ride. excreted mainly in the urine as metabolites; little is ex- Proprietary Preparations (details are given in Part 3) 1. Anonymous. Is there any evidence that Benylin syrup is addic- creted as unchanged drug. The elimination half-life has Indon.: Migristene; Mex.: Migristene. tive? BMJ 1979; 1: 459. 2. Smith SG, Davis WM. Nonmedical use of butorphanol and been reported to range from 2.4 to 9.3 hours. diphenhydramine. JAMA 1984; 252: 1010. 3. Feldman MD, Behar M. A case of massive diphenhydramine ◊ References. abuse and withdrawal from use of the drug. JAMA 1986; 255: 1. Glazko AJ, et al. Metabolic disposition of diphenhydramine. Diphenhydramine (BAN, rINN) 3119–20. Clin Pharmacol Ther 1974; 16: 1066–76. 2. Paton DM, Webster DR. Clinical pharmacokinetics of H -recep- Benzhydramine; Difenhidramina; Difenhydramiini; Difenhy- 4. de Nesnera AP. Diphenhydramine dependence: a need for aware- ness. J Clin Psychiatry 1996; 57: 136–7. tor antagonists (the antihistamines). Clin Pharmacokinet 1985; dramin; Diphénhydramine; Diphenhydraminum. 2-Benzhydry- 5. Dinndorf PA, et al. Risk of abuse of diphenhydramine in children 10: 477–97. (includes studies
Load more

Recommended publications
  • ERJ-01090-2018.Supplement
    Shaheen et al Online data supplement Prescribed analgesics in pregnancy and risk of childhood asthma Seif O Shaheen, Cecilia Lundholm, Bronwyn K Brew, Catarina Almqvist. 1 Shaheen et al Figure E1: Data available for analysis Footnote: Numbers refer to adjusted analyses (complete data on covariates) 2 Shaheen et al Table E1. Three classes of analgesics included in the analyses ATC codes Generic drug name Opioids N02AA59 Codeine, combinations excluding psycholeptics N02AA79 Codeine, combinations with psycholeptics N02AA08 Dihydrocodeine N02AA58 Dihydrocodeine, combinations N02AC04 Dextropropoxyphene N02AC54 Dextropropoxyphene, combinations excluding psycholeptics N02AX02 Tramadol Anti-migraine N02CA01 Dihydroergotamine N02CA02 Ergotamine N02CA04 Methysergide N02CA07 Lisuride N02CA51 Dihydroergotamine, combinations N02CA52 Ergotamine, combinations excluding psycholeptics N02CA72 Ergotamine, combinations with psycholeptics N02CC01 Sumatriptan N02CC02 Naratriptan N02CC03 Zolmitriptan N02CC04 Rizatriptan N02CC05 Almotriptan N02CC06 Eletriptan N02CC07 Frovatriptan N02CX01 Pizotifen N02CX02 Clonidine N02CX03 Iprazochrome N02CX05 Dimetotiazine N02CX06 Oxetorone N02CB01 Flumedroxone Paracetamol N02BE01 Paracetamol N02BE51 Paracetamol, combinations excluding psycholeptics N02BE71 Paracetamol, combinations with psycholeptics 3 Shaheen et al Table E2. Frequency of analgesic classes prescribed to the mother during pregnancy Opioids Anti- Paracetamol N % migraine No No No 459,690 93.2 No No Yes 9,091 1.8 Yes No No 15,405 3.1 No Yes No 2,343 0.5 Yes No
    [Show full text]
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
    [Show full text]
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8,603,526 B2 Tygesen Et Al
    USOO8603526B2 (12) United States Patent (10) Patent No.: US 8,603,526 B2 Tygesen et al. (45) Date of Patent: Dec. 10, 2013 (54) PHARMACEUTICAL COMPOSITIONS 2008. O152595 A1 6/2008 Emigh et al. RESISTANT TO ABUSE 2008. O166407 A1 7/2008 Shalaby et al. 2008/0299.199 A1 12/2008 Bar-Shalom et al. 2008/0311205 A1 12/2008 Habib et al. (75) Inventors: Peter Holm Tygesen, Smoerum (DK); 2009/0022790 A1 1/2009 Flath et al. Jan Martin Oevergaard, Frederikssund 2010/0203129 A1 8/2010 Andersen et al. (DK); Karsten Lindhardt, Haslev (DK); 2010/0204259 A1 8/2010 Tygesen et al. Louise Inoka Lyhne-versen, Gentofte 2010/0239667 A1 9/2010 Hemmingsen et al. (DK); Martin Rex Olsen, Holbaek 2010, O291205 A1 11/2010 Downie et al. (DK); Anne-Mette Haahr, Birkeroed 2011 O159100 A1 6/2011 Andersen et al. (DK); Jacob Aas Hoellund-Jensen, FOREIGN PATENT DOCUMENTS Frederikssund (DK); Pemille Kristine Hoeyrup Hemmingsen, Bagsvaerd DE 20 2006 014131 1, 2007 (DK) EP O435,726 8, 1991 EP O493513 7, 1992 EP O406315 11, 1992 (73) Assignee: Egalet Ltd., London (GB) EP 1213014 6, 2002 WO WO 89,09066 10, 1989 (*) Notice: Subject to any disclaimer, the term of this WO WO91,040 15 4f1991 patent is extended or adjusted under 35 WO WO95/22962 8, 1995 U.S.C. 154(b) by 489 days. WO WO99,51208 10, 1999 WO WOOOf 41704 T 2000 WO WO 03/024426 3, 2003 (21) Appl. No.: 12/701,429 WO WOO3,O24429 3, 2003 WO WOO3,O24430 3, 2003 (22) Filed: Feb.
    [Show full text]
  • Partial Agreement in the Social and Public Health Field
    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
    [Show full text]
  • Pharmaceuticals Appendix
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ADAPALENE 106685-40-9 ABANOQUIL 90402-40-7 ADAPROLOL 101479-70-3 ABECARNIL 111841-85-1 ADEMETIONINE 17176-17-9 ABLUKAST 96566-25-5 ADENOSINE PHOSPHATE 61-19-8 ABUNIDAZOLE 91017-58-2 ADIBENDAN 100510-33-6 ACADESINE 2627-69-2 ADICILLIN 525-94-0 ACAMPROSATE 77337-76-9 ADIMOLOL 78459-19-5 ACAPRAZINE 55485-20-6 ADINAZOLAM 37115-32-5 ACARBOSE 56180-94-0 ADIPHENINE 64-95-9 ACEBROCHOL 514-50-1 ADIPIODONE 606-17-7 ACEBURIC ACID 26976-72-7 ADITEREN 56066-19-4 ACEBUTOLOL 37517-30-9 ADITOPRIME 56066-63-8 ACECAINIDE 32795-44-1 ADOSOPINE 88124-26-9 ACECARBROMAL 77-66-7 ADOZELESIN 110314-48-2 ACECLIDINE 827-61-2 ADRAFINIL 63547-13-7 ACECLOFENAC 89796-99-6 ADRENALONE 99-45-6 ACEDAPSONE 77-46-3 AFALANINE 2901-75-9 ACEDIASULFONE SODIUM 127-60-6 AFLOQUALONE 56287-74-2 ACEDOBEN 556-08-1 AFUROLOL 65776-67-2 ACEFLURANOL 80595-73-9 AGANODINE 86696-87-9 ACEFURTIAMINE 10072-48-7 AKLOMIDE 3011-89-0 ACEFYLLINE CLOFIBROL 70788-27-1
    [Show full text]
  • Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
    MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01
    [Show full text]
  • Screening of 300 Drugs in Blood Utilizing Second Generation
    Forensic Screening of 300 Drugs in Blood Utilizing Exactive Plus High-Resolution Accurate Mass Spectrometer and ExactFinder Software Kristine Van Natta, Marta Kozak, Xiang He Forensic Toxicology use Only Drugs analyzed Compound Compound Compound Atazanavir Efavirenz Pyrilamine Chlorpropamide Haloperidol Tolbutamide 1-(3-Chlorophenyl)piperazine Des(2-hydroxyethyl)opipramol Pentazocine Atenolol EMDP Quinidine Chlorprothixene Hydrocodone Tramadol 10-hydroxycarbazepine Desalkylflurazepam Perimetazine Atropine Ephedrine Quinine Cilazapril Hydromorphone Trazodone 5-(p-Methylphenyl)-5-phenylhydantoin Desipramine Phenacetin Benperidol Escitalopram Quinupramine Cinchonine Hydroquinine Triazolam 6-Acetylcodeine Desmethylcitalopram Phenazone Benzoylecgonine Esmolol Ranitidine Cinnarizine Hydroxychloroquine Trifluoperazine Bepridil Estazolam Reserpine 6-Monoacetylmorphine Desmethylcitalopram Phencyclidine Cisapride HydroxyItraconazole Trifluperidol Betaxolol Ethyl Loflazepate Risperidone 7(2,3dihydroxypropyl)Theophylline Desmethylclozapine Phenylbutazone Clenbuterol Hydroxyzine Triflupromazine Bezafibrate Ethylamphetamine Ritonavir 7-Aminoclonazepam Desmethyldoxepin Pholcodine Clobazam Ibogaine Trihexyphenidyl Biperiden Etifoxine Ropivacaine 7-Aminoflunitrazepam Desmethylmirtazapine Pimozide Clofibrate Imatinib Trimeprazine Bisoprolol Etodolac Rufinamide 9-hydroxy-risperidone Desmethylnefopam Pindolol Clomethiazole Imipramine Trimetazidine Bromazepam Felbamate Secobarbital Clomipramine Indalpine Trimethoprim Acepromazine Desmethyltramadol Pipamperone
    [Show full text]
  • Marrakesh Agreement Establishing the World Trade Organization
    No. 31874 Multilateral Marrakesh Agreement establishing the World Trade Organ ization (with final act, annexes and protocol). Concluded at Marrakesh on 15 April 1994 Authentic texts: English, French and Spanish. Registered by the Director-General of the World Trade Organization, acting on behalf of the Parties, on 1 June 1995. Multilat ral Accord de Marrakech instituant l©Organisation mondiale du commerce (avec acte final, annexes et protocole). Conclu Marrakech le 15 avril 1994 Textes authentiques : anglais, français et espagnol. Enregistré par le Directeur général de l'Organisation mondiale du com merce, agissant au nom des Parties, le 1er juin 1995. Vol. 1867, 1-31874 4_________United Nations — Treaty Series • Nations Unies — Recueil des Traités 1995 Table of contents Table des matières Indice [Volume 1867] FINAL ACT EMBODYING THE RESULTS OF THE URUGUAY ROUND OF MULTILATERAL TRADE NEGOTIATIONS ACTE FINAL REPRENANT LES RESULTATS DES NEGOCIATIONS COMMERCIALES MULTILATERALES DU CYCLE D©URUGUAY ACTA FINAL EN QUE SE INCORPOR N LOS RESULTADOS DE LA RONDA URUGUAY DE NEGOCIACIONES COMERCIALES MULTILATERALES SIGNATURES - SIGNATURES - FIRMAS MINISTERIAL DECISIONS, DECLARATIONS AND UNDERSTANDING DECISIONS, DECLARATIONS ET MEMORANDUM D©ACCORD MINISTERIELS DECISIONES, DECLARACIONES Y ENTEND MIENTO MINISTERIALES MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION ACCORD DE MARRAKECH INSTITUANT L©ORGANISATION MONDIALE DU COMMERCE ACUERDO DE MARRAKECH POR EL QUE SE ESTABLECE LA ORGANIZACI N MUND1AL DEL COMERCIO ANNEX 1 ANNEXE 1 ANEXO 1 ANNEX
    [Show full text]
  • Pharmaceutical Appendix to the Harmonized Tariff Schedule
    Harmonized Tariff Schedule of the United States Basic Revision 3 (2021) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States Basic Revision 3 (2021) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
    [Show full text]
  • Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca2+ -Channel Blocker, on Ba2+ Current Through Voltage-Gated Ca2+ Channels in PC 12 Cells
    Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca2+ -Channel Blocker, on Ba2+ Current through Voltage-Gated Ca2+ Channels in PC 12 Cells Tomokazu Watanol, Hideaki Hara2,* and Takayuki Sukamoto2 1 Department of Pharmacology, New Drug Discovery Research Laboratory, Kanebo Ltd., 1-5-90 Tomobuchi-cho,of Pharmacology, Miyakojima-ku, New Drug Osaka R & 534,D Laboratory, Japan2Department Kanebo Ltd., 1-5-90 Tomobuchi-cho, Miyakojima-ku, Osaka 534, Japan Received July 8, 1997 Accepted August 22, 1997 ABSTRACT-We investigated the effect of lomerizine, an anti-migraine drug, on the Ba2+ current through voltage-gated Ca2+ channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp tech nique. Lomerizine inhibited the Ba2+ current with an IC50 value of 1.9 ƒÊM. Lomerizine and nicardipine were > 4 times more potent than flunarizine, diltiazem, verapamil and dimetotiazine. The time course of inactivation induced by lomerizine was similar to that induced by nicardipine and flunarizine. These data indicate that lomerizine may inhibit the Ca2+ channel in a similar manner to nicardipine and flunarizine, and its potency is almost equal to that of nicardipine. Keywords: Lomerizine , Voltage-gated Ca2+ channel, PCl2 cell Calcium channel blockers are mainly divided into three Bio Medical, Kyoto) containing 7° fetal bovine serum types, namely, 1,4-dihydropyridine, phenylalkylamine (Moregate, Melbourne, Australia), 7% heat-inactivated and benzothiazepine types, from their structure (1). horse serum (Gibco, Grand Island, NY, USA), 2 MM L Lomerizine, 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4 glutamine (Wako, Osaka) and 50 pg/ml gentamicin sul trimethoxybenzyl)piperazine dihydrochloride has been fate (Wako) at 37C in an atmosphere of 5% CO2.
    [Show full text]
  • Alphabetical Listing of ATC Drugs & Codes
    Alphabetical Listing of ATC drugs & codes. Introduction This file is an alphabetical listing of ATC codes as supplied to us in November 1999. It is supplied free as a service to those who care about good medicine use by mSupply support. To get an overview of the ATC system, use the “ATC categories.pdf” document also alvailable from www.msupply.org.nz Thanks to the WHO collaborating centre for Drug Statistics & Methodology, Norway, for supplying the raw data. I have intentionally supplied these files as PDFs so that they are not quite so easily manipulated and redistributed. I am told there is no copyright on the files, but it still seems polite to ask before using other people’s work, so please contact <[email protected]> for permission before asking us for text files. mSupply support also distributes mSupply software for inventory control, which has an inbuilt system for reporting on medicine usage using the ATC system You can download a full working version from www.msupply.org.nz Craig Drown, mSupply Support <[email protected]> April 2000 A (2-benzhydryloxyethyl)diethyl-methylammonium iodide A03AB16 0.3 g O 2-(4-chlorphenoxy)-ethanol D01AE06 4-dimethylaminophenol V03AB27 Abciximab B01AC13 25 mg P Absorbable gelatin sponge B02BC01 Acadesine C01EB13 Acamprosate V03AA03 2 g O Acarbose A10BF01 0.3 g O Acebutolol C07AB04 0.4 g O,P Acebutolol and thiazides C07BB04 Aceclidine S01EB08 Aceclidine, combinations S01EB58 Aceclofenac M01AB16 0.2 g O Acefylline piperazine R03DA09 Acemetacin M01AB11 Acenocoumarol B01AA07 5 mg O Acepromazine N05AA04
    [Show full text]