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Pharmacopoeias. In Eur. (see p.vii). Diphenhydramine Citrate (BANM, rINNM) There have been reports3,4 of rhabdomyolysis as an effect of oral Ph. Eur. 6.2 ( Maleate). A white to almost white, Benzhydramine Citrate; Citrato de difenhidramina; Diphénhy- diphenhydramine overdosage. The liberal application of a lotion crystalline powder. Slightly soluble in water; soluble in methyl containing diphenhydramine produced acute delirium with visu- dramine, Citrate de; Diphenhydramini Citras. . Protect from light. al and auditory hallucinations in a 9-year-old boy5 and similar Дифенгидрамина Цитрат Profile effects were seen in 3 children with varicella-zoster infection fol- C17H21NO,C6H8O7 = 447.5. lowing the topical application of diphenhydramine (2 of these Dimetindene maleate, an alkylamine derivative, is a sedating an- CAS — 88637-37-0. children also received oral diphenhydramine).6 tihistamine (p.561); it is mildly sedative and is reported to have ATC — D04AA32; R06AA02. 1. Köppel C, Tenczer J. Clinical symptomatology of diphenhy- mast-cell stabilising properties. It is used for the symptomatic re- ATC Vet — QD04AA32; QR06AA02. dramine overdose: an evaluation of 136 cases in 1982 to 1985. lief of allergic conditions including urticaria and angioedema Pharmacopoeias. In US. Clin Toxicol 1987; 25: 53–70. (p.565) and rhinitis (p.565), and in pruritic skin disorders (p.565). USP 31 (Diphenhydramine Citrate). Store in airtight containers. 2. Radovanovic D, et al. Dose-dependent toxicity of diphenhy- It is also used in compound preparations for the symptomatic dramine overdose. Hum Exp Toxicol 2000; 19: 489–95. Protect from light. treatment of coughs and the common cold (p.564). 3. Hampel G, et al. Myoglobinuric renal failure due to -in- duced rhabdomyolysis. Hum Toxicol 1983; 2: 197–203. Dimetindene maleate is given in an oral dose of 1 to 2 mg three Diphenhydramine Di(acefyllinate) (rINNM) 4. Haas CE, et al. Rhabdomyolysis and acute renal failure follow- times daily; modified-release preparations are also available. It ing an and diphenhydramine overdose. Ann Pharmaco- may also be given by the intravenous route. Dimetindene Benzhydramine Di(acefyllinate); Bietanautine; Di(acefilinato) de ther 2003; 37: 538–42. maleate is applied topically as a 0.1% gel or lotion although, as difenhidramina; Diphénhydramine Diacéfylline; Diphenhy- 5. Filloux F. Toxic encephalopathy caused by topically applied with other , there is a risk of sensitisation. It is used dramine Di(acephyllinate); Diphenhydramini Diacefyllinas. diphenhydramine. J Pediatr 1986; 108: 1018–20. 6. Chan CYJ, Wallander KA. Diphenhydramine toxicity in three in a strength of 0.025% in compound nasal preparations. Diphenhydramine bis(theophyllin-7-ylacetate). children with varicella-zoster infection. DICP Ann Pharmacoth- Preparations Дифенгидрамина Диацефиллинат er 1991; 25: 130–2. Proprietary Preparations (details are given in Part 3) C17H21NO,2C9H10N4O4 = 731.8. Porphyria. Diphenhydramine has been associated with acute Austria: Fenistil; Belg.: Fenistil; Cz.: Fenistil; Ger.: Fenistil; Gr.: Fenistil; CAS — 6888-11-5. attacks of porphyria and is considered unsafe in porphyric pa- Hung.: Fenistil; India: Foristal; Indon.: Fenistil; Israel: Fenistil; Ital.: Fenistil; ATC — D04AA32; R06AA02. tients. Neth.: Fenistil; Norw.: Fenistil†; Philipp.: Fenistil; Pol.: Fenistil; Port.: Fen- ATC Vet — QD04AA32; QR06AA02. istil; Neostil; Rus.: Fenistil (Фенистил); Spain: Fenistil; Switz.: Fenistil; Pregnancy. A pregnant woman who was receiving diphenhy- Thai.: Fenistil; Turk.: Fenistil; Venez.: Fenistil†. NOTE. The name Etanautine has been applied both to diphenhy- dramine hydrochloride 150 mg daily for a pruritic rash gave birth Multi-ingredient: Arg.: Vibragel; Austria: Trimedil; Vibrocil; Belg.: Vi- dramine monoacefyllinate and to ethylbenzhydramine, an an- to an infant who developed diarrhoea and generalised tremulous- brocil; Braz.: Gripen; Trimedal; Cz.: Vibrocil; Ger.: Vibrocil†; Gr.: Vibrocil- timuscarinic formerly used in the symptomatic treatment of par- ness 5 days later.1 The delay in appearance of withdrawal symp- S; Hong Kong: Vibrocil†; Hung.: Otrivin Allergia; Vibrocil; Israel: Vibrocil; kinsonism. Ital.: Vibrocil; Pol.: Otrivin Allergy; Port.: Vibrocil; Rus.: Vibrocil toms was considered to be due to reduced activity of glucuronyl (Виброцил); S.Afr.: Vibrocil; Vibrocil-S; Switz.: Vibrocil. conjugating in the first few days of life. Diphenhydramine Hydrochloride (BANM, rINNM) For discussion of the use of antihistamines in pregnancy, includ- Benzhydramine Hydrochloride; Difenhidramin Hidroklorür; ing a suggestion of a relationship between inguinal hernia or gen- Difenhidramin-hidroklorid; Difenhidramino hidrochloridas; ito-urinary malformations and diphenhydramine exposure, see Dimetotiazine Mesilate (BANM, rINNM) Difenhydramiinihydrokloridi; Difenhydramin-hydrochlorid; Difen- p.563. See also under Interactions, below, for a report of perinatal Dimethothiazine Mesylate; Dimétotiazine, Mésilate de; Dimeto- hydraminhydroklorid; Difenhydraminy chlorowodorek; Dime- death possibly associated with temazepam and diphenhy- tiazini Mesilas; Fonazine Mesylate (USAN); IL-6302 (dimetotiazine); drolum; Diphénhydramine, chlorhydrate de; Diphenhydramini dramine. Mesilato de dimetotiazina; 8599-RP (dimetotiazine). 10-(2- hydrochloridum; Diphenhydraminium Chloride; Hidrocloruro 1. Parkin DE. Probable Benadryl withdrawal manifestations in a new-born infant. J Pediatr 1974; 85: 580. Dimethylaminopropyl)-NN-dimethylphenothiazine-2-sulphona- de difenhidramina. mide methanesulphonate. Дифенгидрамина Гидрохлорид Interactions Диметотиазина Мезилат C17H21NO,HCl = 291.8. As for the sedating antihistamines in general, p.563. C19H25N3O2S2,CH3SO3H = 487.7. CAS — 147-24-0. CAS — 7456-24-8 (dimetotiazine); 7455-39-2 (dimeto- ATC — D04AA32; R06AA02. Diphenhydramine inhibits the cytochrome P450 isoen- tiazine mesilate). ATC Vet — QD04AA32; QR06AA02. zyme CYP2D6 that is partly responsible for the metab- ATC — N02CX05. Pharmacopoeias. In Chin., Eur. (see p.vii), Jpn, and US. olism of some beta blockers including metoprolol and ATC Vet — QN02CX05. Jpn also includes Diphenhydramine Tannate. the venlafaxine. Ph. Eur. 6.2 (Diphenhydramine Hydrochloride). A white or al- 1 most white, crystalline powder. Very soluble in water; freely sol- . There has been a report suggesting that a H3C CH3 uble in alcohol. A 5% solution in water has a pH of 4.0 to 6.0. reduction in temazepam metabolism caused by diphenhy- N Protect from light. dramine may have contributed to perinatal death after ingestion USP 31 (Diphenhydramine Hydrochloride). A white, odourless, of these by the mother. O O crystalline powder. It slowly darkens on exposure to light. Solu- 1. Kargas GA, et al. Perinatal mortality due to interaction of CH3 diphenhydramine and temazepam. N Engl J Med 1985; 313: ble 1 in 1 of water, 1 in 2 of alcohol and of chloroform, and 1 in 1417–18. N S CH3 50 of acetone; very slightly soluble in ether and in benzene. Its N solutions are neutral to litmus. Store in airtight containers. Pro- Pharmacokinetics tect from light. Diphenhydramine hydrochloride is well absorbed CH S 3 Incompatibility. Diphenhydramine hydrochloride has been re- from the gastrointestinal tract, although high first-pass ported to be incompatible with amphotericin B, cefmetazole so- (dimetotiazine) dium, cefalotin sodium, hydrocortisone sodium succinate, some metabolism appears to affect systemic availability. soluble , some contrast media, and solutions of alka- Peak plasma concentrations are achieved about 1 to 4 Profile lis or strong acids. hours after oral doses. Diphenhydramine is widely dis- Dimetotiazine mesilate, a derivative, is a sedating tributed throughout the body including the CNS. It (p.561). It has been used for the symptomatic relief Adverse Effects and Precautions crosses the placenta and has been detected in breast of hypersensitivity reactions, in pruritic skin disorders, and in the As for the sedating antihistamines in general, p.561. management of headaches including . milk. Diphenhydramine is highly bound to plasma pro- Abuse. Reports of the abuse of diphenhydramine hydrochlo- teins. Metabolism is extensive. Diphenhydramine is Preparations ride. excreted mainly in the urine as metabolites; little is ex- Proprietary Preparations (details are given in Part 3) 1. Anonymous. Is there any evidence that Benylin syrup is addic- creted as unchanged drug. The elimination half-life has Indon.: Migristene; Mex.: Migristene. tive? BMJ 1979; 1: 459. 2. Smith SG, Davis WM. Nonmedical use of butorphanol and been reported to range from 2.4 to 9.3 hours. diphenhydramine. JAMA 1984; 252: 1010. 3. Feldman MD, Behar M. A case of massive diphenhydramine ◊ References. abuse and withdrawal from use of the drug. JAMA 1986; 255: 1. Glazko AJ, et al. Metabolic disposition of diphenhydramine. Diphenhydramine (BAN, rINN) 3119–20. Clin Pharmacol Ther 1974; 16: 1066–76. 2. Paton DM, Webster DR. Clinical pharmacokinetics of H -recep- Benzhydramine; Difenhidramina; Difenhydramiini; Difenhy- 4. de Nesnera AP. Diphenhydramine dependence: a need for aware- ness. J Clin Psychiatry 1996; 57: 136–7. tor antagonists (the antihistamines). Clin Pharmacokinet 1985; dramin; Diphénhydramine; Diphenhydraminum. 2-Benzhydry- 5. Dinndorf PA, et al. Risk of abuse of diphenhydramine in children 10: 477–97. (includes studies indicating a correlation between loxy-NN-dimethylethylamine. and adolescents with chronic illnesses. J Pediatr 1998; 133: plasma concentrations and both antihistaminic and sedative ef- 293–5. fects). Дифенгидрамин 3. Simons KJ, et al. Diphenhydramine: pharmacokinetics and phar- Extrapyramidal disorders. Reports of dystonic extrapyrami- C17H21NO = 255.4. macodynamics in elderly adults, young adults, and children. J CAS — 58-73-1. dal reactions to diphenhydramine. Clin Pharmacol 1990; 30: 665–71. 1. Lavenstein BL, Cantor FK. Acute dystonia: an unusual reaction 4. Scavone JM, et al. Pharmacokinetics and pharmacodynamics of ATC — D04AA32; R06AA02. to diphenhydramine. JAMA 1976; 236: 291. diphenhydramine 25 mg in young and elderly volunteers. J Clin ATC Vet — QD04AA32; QR06AA02. 2. Santora J, Rozek S. Diphenhydramine-induced dystonia. Clin Pharmacol 1998; 38: 603–9. Pharm 1989; 8: 471. 3. Roila F, et al. Diphenhydramine and acute dystonia. Ann Intern Uses and Administration Med 1989; 111: 92–3. CH3 Diphenhydramine, a monoethanolamine derivative, is Overdosage. In an evaluation of 136 cases, one fatal, of intox- a sedating antihistamine with antimuscarinic and pro- ication with diphenhydramine, the plasma concentration was N 1 nounced sedative properties. It is used for the sympto- O CH correlated with frequency or extent of symptoms. The most 3 common symptom was impaired consciousness; psychosis, sei- matic relief of allergic conditions including urticaria zures, antimuscarinic symptoms such as mydriasis, tachycardia, and angioedema (p.565), rhinitis (p.565) and conjunc- and tachyarrhythmias, and respiratory failure were also ob- tivitis (p.564), and in pruritic skin disorders (p.565). It served. The positive association between dose and frequency and severity of symptoms was confirmed in a more recent study;2 it is also used for its antiemetic properties in the treat- was also found that severe symptoms were more likely to occur ment of nausea and vomiting (p.564), particularly in Pharmacopoeias. In Jpn. when 1 g or more of diphenhydramine had been taken. the prevention and treatment of motion sickness (when The symbol † denotes a preparation no longer actively marketed The symbol ⊗ denotes a substance whose use may be restricted in certain sports (see p.vii) 578 Antihistamines it should be given at least 30 minutes before travelling), dorm; Sleep Aid; Sleepeaze; USA: 40 Winks; Aler-Dryl; AllerMax; Altaryl Childrens Allergy; Banophen Allergy; Ben-Tann; Benadryl; Benadryl Allergy; and in the treatment of vertigo of various causes Benadryl Childrens Allergy; Benadryl Itch; Childrens PediaCare Nighttime (p.565). Diphenhydramine is used for its antimuscarin- Cough; Compoz Night-time Sleep Aid; Dermamycin; Diphen AF; Diphen- hist; Dormin; Dytan; Dytuss; Genahist; Maximum Strength Sleepinal; Maxi- ic properties in the control of (p.791) and mum Strength Unisom SleepGels; Miles Nervine; MouthKote P/R†; Nytol; CH3 drug-induced extrapyramidal disorders (p.971) (al- Scot-Tussin Allergy; Siladryl; Silphen; Simply Sleep; Sleep-Ettes D; Sleepwell CH3 2-nite; Snooze Fast; Sominex; Triaminic Cough & Runny Nose; Tusstat; Twi- though the possibility that diphenhydramine itself may lite; Venez.: Benadryl; Di-Fedril†; Ystal†. N N O cause extrapyramidal symptoms should be remem- Multi-ingredient: numerous preparations are listed in Part 3. CH3 bered). Diphenhydramine has pronounced central sed- ative properties and may be used as a hypnotic in the short-term management of insomnia (p.564). It is a Hydrochloride (BANM, rINNM) () common ingredient of compound preparations for Diphénylpyraline, Chlorhydrate de; Diphenylpyralini Hydrochlo- symptomatic treatment of coughs and the common Pharmacopoeias. In Eur. (see p.vii) and US. ridum; Hidrocloruro de difenilpiralina. 4-Benzhydryloxy-1-meth- Ph. Eur. 6.2 (Doxylamine Hydrogen Succinate; Doxylamine Suc- cold (p.564). However, such preparations should be ylpiperidine hydrochloride. cinate BP 2008). A white or almost white powder. Very soluble in used with caution in children, and generally avoided in Дифенилпиралина Гидрохлорид water; freely soluble in alcohol. those under 2 years of age (see p.562). It may also be C19H23NO,HCl = 317.9. USP 31 (Doxylamine Succinate). A white or creamy-white pow- given in combination preparations containing analge- CAS — 147-20-6 (diphenylpyraline); 132-18-3 (diphe- der having a characteristic odour. Soluble 1 in 1 of water, 1 in 2 sics, particularly . Diphenhydramine may nylpyraline hydrochloride). of alcohol and of chloroform, and 1 in 370 of ether; very slightly be used parenterally as an adjunct in the emergency ATC — R06AA07. soluble in benzene. Protect from light. treatment of anaphylactic shock (p.563) or when oral ATC Vet — QR06AA07. Adverse Effects and Precautions therapy is not feasible. As for the sedating antihistamines in general, p.561. The contro- versy surrounding the use in pregnancy of combination products For most indications, diphenhydramine hydrochloride of doxylamine is discussed on p.563. is given in usual oral doses of 25 to 50 mg three or four O Overdosage. In an evaluation of 109 cases of intoxication with times daily. The dose for children is 6.25 to 25 mg doxylamine,1 no correlation was found between the amount in- three or four times daily, or a total daily dose of gested or plasma concentration and the frequency or extent of 5 mg/kg may be given in divided doses. The maximum N symptoms. The most common symptom was impaired con- H3C sciousness. Psychotic behaviour, seizures, and antimuscarinic dose in adults and children is about 300 mg daily. A symptoms such as tachycardia and mydriasis were also ob- dose of 20 to 50 mg may be used as a hypnotic in adults served. Rhabdomyolysis occurred in one patient and was accom- and children over 12 years old. panied by transient impairment of renal function. The same (diphenylpyraline) group commented2 that rhabdomyolysis had been noted in 7 of When oral therapy is not feasible, diphenhydramine 442 cases of doxylamine overdosage, with an associated rise in hydrochloride may be given by deep intramuscular in- Pharmacopoeias. In Br. plasma creatine kinase and myoglobinuria, and suggested that jection or by intravenous injection using concentra- BP 2008 (Diphenylpyraline Hydrochloride). A white or almost doxylamine has a direct toxic effect on striated muscle. tions of 1% or 5%. Usual doses are 10 to 50 mg, al- white, odourless or almost odourless powder. Freely soluble in 1. Köppel C, et al. Poisoning with over-the-counter doxylamine though doses of 100 mg have been given. No more water, in alcohol, and in chloroform; practically insoluble in preparations: an evaluation of 109 cases. Hum Toxicol 1987; 6: ether. 355–9. than 400 mg should be given in 24 hours. Children 2. Köppel C, et al. Rhabdomyolysis in doxylamine overdose. Lan- may be given 5 mg/kg daily in divided doses to a max- Adverse Effects and Precautions cet 1987; i: 442–3. imum of 300 mg in 24 hours. Diphenhydramine hydro- As for the sedating antihistamines in general, p.561. Interactions chloride is applied topically, usually in preparations Interactions As for the sedating antihistamines in general, p.563. containing 1 to 2% although, as with other antihista- As for the sedating antihistamines in general, p.563. Pharmacokinetics mines, there is a risk of sensitisation. Pharmacokinetics After oral doses of doxylamine succinate peak plasma concentra- tions occur after 2 to 3 hours. An elimination half-life of about 10 Diphenhydramine citrate is given orally in a dose of ◊ References. hours has been reported. 76 mg at night in combination preparations for its hyp- 1. Graham G, Bolt AG. Half-life of diphenylpyraline in man. J Pharmacokinet Biopharm 1974; 2: 191–5 (ranged from 24 to 40 ◊ References. notic action. Diphenhydramine di(acefyllinate) is giv- hours). 1. Friedman H, et al. Clearance of the antihistamine doxylamine: en as an antiemetic for the prevention and treatment of reduced in elderly men but not in elderly women. Clin Pharma- Uses and Administration cokinet 1989; 16: 312–16. motion sickness. The usual oral dose is 90 to 135 mg, Diphenylpyraline hydrochloride, a derivative, is a se- which may be repeated if necessary at intervals of at dating antihistamine with antimuscarinic and significant sedative Uses and Administration least 6 hours, to a maximum of 540 mg daily. Other properties. Doxylamine succinate, a monoethanolamine derivative, is a se- dating antihistamine with antimuscarinic and pronounced seda- diphenhydramine salts that have been used include the It has been given for the symptomatic relief of allergic conditions tive effects. polistirex, the salicylate, and the tannate by mouth, the including rhinitis (p.565), and in pruritic skin disorders (p.565). It has also been used in compound preparations for the sympto- Doxylamine succinate is given for the symptomatic relief of hy- methylbromide rectally, and the metilsulfate applied matic treatment of coughs and the common cold (p.564). persensitivity reactions, in pruritic skin disorders (p.565), as a topically. hypnotic in the short-term treatment of insomnia (p.564), and as Diphenylpyraline hydrochloride has been given in an oral dose an ingredient of compound preparations for symptomatic treat- (p.576) is diphenhydramine teoclate of up to 6 mg daily in 3 or 4 divided doses. Diphenylpyraline and ment of coughs and the common cold (p.564). diphenylpyraline hydrochloride have been applied topically al- and mefenidramium metilsulfate is diphenhydramine In general it is no longer used in the management of nausea and methylsulfomethylate. though, as with other antihistamines, there is a risk of sensitisa- tion. vomiting of early pregnancy (see p.563 for the controversy that has surrounded the use in pregnancy of combination products of Preparations Diphenylpyraline teoclate is piprinhydrinate (p.588). doxylamine). BP 2008: Diphenhydramine Oral Solution; Preparations Oral doses of up to 25 mg of doxylamine succinate have been USP 31: Acetaminophen and Diphenhydramine Citrate Tablets; Acetami- Proprietary Preparations (details are given in Part 3) given every 4 to 6 hours to a maximum of 150 mg daily. The nophen, Diphenhydramine Hydrochloride, and Hydro- chloride Tablets; Diphenhydramine and Pseudoephedrine Capsules; Ger.: Arbid N†. usual hypnotic dose is 25 mg orally at night. Diphenhydramine Hydrochloride Capsules; Diphenhydramine Hydrochlo- Multi-ingredient: Austria: Arbid; Astronautal; Eucillin; Prurimix; Tropo- Preparations ride Elixir; Diphenhydramine Hydrochloride Injection. derm; Belg.: Bicold†; Rhini-San; Braz.: Ornatrol†; Canad.: Creo-Rectal; Vito Bronches†; Cz.: Proctospre†; Prurimix†; Ger.: Perdiphen†; Proctos- USP 31: Acetaminophen, Dextromethorphan Hydrobromide, Doxy- Proprietary Preparations (details are given in Part 3) pre†; Tempil N; Hong Kong: Phenahist; India: Eskold Expectorant†; Es- lamine Succinate, and Pseudoephedrine Hydrochloride Oral Solution; Arg.: Alermina; Amodormin; Benadryl; Benadryl Antialergico†; Caladryl D; kold†; Mex.: Flumil; S.Afr.: Actophlem; Eskornade; Solphyllex; Theophen Doxylamine Succinate Syrup; Doxylamine Succinate Tablets. Drepatil†; Fabolergic; Histaler; Klonadryl; Mudantos H†; Austral.: Snuzaid; Comp; Switz.: Arbid. Proprietary Preparations (details are given in Part 3) Unisom; Austria: Calmaben; Dermodrin; Dibondrin; Histaxin; Noctor; Sleepia†; Belg.: Azaron; Benylin; Diphamine; Nuicalm†; Nustasium; R Calm; Austral.: Dozile; Restavit; Canad.: Unisom-2; Chile: Calmex; Dorminoctil; Braz.: Difenidrin; Canad.: Aller-Aide; Allerdryl; Allergy Caplets; Allergy Nocpaz; Trimepaz†; Zarcop; Cz.: Hoggar N†; Fr.: Donormyl; Lidene; Noc- Elixir; Allergy Formula; Allernix; Benadryl; Calmex; Children’s Allergy For- tyl; Ger.: Gittalun; Hewedormir doxyl intens†; Hoggar Night; Mereprine; mula; Dormex; Dormiphen; Insomnal; Jack & Jill Bedtime; Jack & Jill Thin Doxylamine Succinate (BANM, rINNM) Munleit†; SchlafTabs; Sedaplus; India: Rest-Aid; Israel: Sleep Aid; Unisom; NZ: Dozile; Philipp.: Unisom; Port.: Dormidina; S.Afr.: Equi-Sleep†; Rest- Strips Cough & Cold; Neo Citran Nighttime Cough; Nytol; Simply Sleep; Doksilamin Süksinat; Doksilamino-vandenilio sukcinatas; Doksy- Sleep Aid; Sleep-Eze D; Sominex; Triaminic Thin Strips Nighttime Cough & wel; Somnil; Spain: Dormidina; Switz.: Sanalepsi N; Turk.: Unisom; USA: Runny Nose; Unisom; Chile: Jaquedryl; Pasifen†; Somol; Cz.: Benadryl N†; lamiinivetysuksinaatti; Doxilamin-hidrogén-szukcinát; Doxy- Aldex AN; Unisom SleepTabs. Psilo-Balsam; Fr.: Butix; Nautamine; Ger.: Benadryl N†; Betadorm D; lamine Hydrogen Succinate; Doxylamine, hydrogénosuccinate Multi-ingredient: Austral.: /Calmative; Codalgin Plus; Dolestan; Dormutil N†; Emesan; Halbmond†; Hevert-Dorm; Moradorm; de; Doxylamine, Succinate de; Doxylamin-hydrogen-sukcinát; Dimetapp Cold, Cough & Flu; Dolased Analgesic Calmative; Dolased nervo OPT N; ratioAllerg†; S.8; Sedativum-Hevert; Sediat; Sedopretten; Day/Night Pain Relief; Fiorinal; Mersyndol; Ordov Migradol†; Panadeine Sleepia†; Vivinox Sleep; Gr.: Benadryl; Hong Kong: Benadryl†; Calox†; Hy- Doxylamini hydrogenosuccinas; Doxylamini Succinas; Doxy- Plus; Panalgesic; Austria: Wick Erkaltungs-Saft fur die Nacht; Wick Husten- dramine Cream†; Unisom; Hung.: Psilo-Balsam; India: Benadryl; Cofryl; laminium Succinate; Doxylaminvätesuccinat; Histadoxylamine saft; Belg.: Pholco-Mereprine; Braz.: Broncolex†; EMS Expectorante; Hy- Dimiril†; Indon.: Arcodryl; Benadryl; Otede; Paradryl; Recodryl; Sidiadryl; Succinate; Succinato de doxilamina. NN-Dimethyl-2-[α-methyl- tos Plus; Revenil; Revenil Dospan; Revenil Expectorante; Silencium; Silomat Israel: Nytol; Ital.: Aliserin; Allergan; Nytol†; Mex.: Benadryl; Bionaryl; Bo- Plus†; Canad.: Dalmacol; Diclectin; Mersyndol with Codeine; Neo Citran nanoti; Drafen; Glicodril; Histadryl; Indumir; Lurispan; Nytol; Tzoali†; Ulcoid; α-(2-pyridyl)benzyloxy]ethylamine hydrogen succinate. Cold & Flu†; Nighttime; Nighttime Cold & Flu; Nyquil Sinus; NyQuil†; ratio- Unisom†; NZ: Unisom; Philipp.: Allerin AH; Benadryl Antihistamine; Доксиламина Суксинат Calmydone; Regular Strength Sinus ; Tylenol Sinus (Nighttime Benaxil; Dramelin; Port.: Benaderma; Benergina; Codilergi; Nytol†; Rus.: Relief); Vicks Nyquil Cold & Flu; Cz.: Wick Medinait†; Fr.: DolirhumePro; Psilo-Balsam (Псило-Бальзам); S.Afr.: Betasleep; Sleepeze-PM; Singa- C17H22N2O,C4H6O4 = 388.5. Ger.: Paedisup; Wick Medinait; India: Doxinate; Vominate; Indon.: Dex- pore: Benocten; Paxidorm; Spain: Benadryl; Neosayomol; Nytol; Sono- CAS — 469-21-6 (doxylamine); 562-10-7 (doxylamine molex; Siladex; Irl.: Syndol; Ital.: Vicks Medinait; NZ: Dimetapp Cold, dor; Swed.: Desentol; Switz.: Bedorma; Benocten; Comprimes somniferes succinate). Cough & Flu Day & Night†; Mersyndol; Pryndette†; Pol.: Tabcin Impakt; "S"; Dobacen†; Sleepia†; Thai.: Benadryl; Turk.: Allenik; Allerjin; Benison; Port.: Nausefe; S.Afr.: Abflex; Acurate; Adco-Dol; Asic; B-Dol; Betapyn; Fenotral; UAE: Amydramine II; UK: Adult Chesty Cough; Child Chesty ATC — R06AA09. Cepacol; Codoxol; Doxsyn; Forpyn†; Lenapain; Nethaprin Dospan; Neth- Cough; Dreemon; Histergan; Mandalyn Paediatric; Nightcalm; Nytol; Paxi- ATC Vet — QR06AA09. aprin Expectorant; Nomopain; Paxidal; Pynclear†; Pynstop; Sedapain; Sedi-