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International Genome-Wide Meta-Analysis Identifies New Primary Biliary Cirrhosis Risk Loci and Targetable Pathogenic Pathways
Cordell H, Han Y, Mells G, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D, Qian DC, Floyd JAB, Morley KI, Prati D, Lleo A, Cusi D, Canadian-US PBC Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Gershwin ME, Anderson CA, Lazaridis KN, Invernizzi P, Seldin MF, Sandford RN, Amos CI, Siminovitch K. International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. Nature Communications 2015, 6: 8019. Copyright: © 2015 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ DOI link to article: http://dx.doi.org/10.1038/ncomms9019 Date deposited: 01/10/2015 This work is licensed under a Creative Commons Attribution 4.0 International License Newcastle University ePrints - eprint.ncl.ac.uk ARTICLE Received 30 Jan 2015 | Accepted 3 Jul 2015 | Published 22 Sep 2015 DOI: 10.1038/ncomms9019 OPEN International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways Heather J. Cordell1, Younghun Han2, George F. Mells3, Yafang Li2, Gideon M. Hirschfield4, Casey S. Greene5, Gang Xie6, Brian D. Juran7, Dakai Zhu2, David C. Qian2, James A.B. -
BMJ in the News Is a Weekly Digest of BMJ Stories, Plus Any Other News
BMJ in the News is a weekly digest of BMJ stories, plus any other news about the company that has appeared in the national and a selection of English-speaking international media. This week’s (24-30 July) highlights: ● Researchers in The BMJ question whether patients should finish their course of antibiotics. The story was covered across the globe, including an interview with the author on BBC Radio 4 Today, ITV Good Morning Britain, CNN and Washington Post ● Also in The BMJ this week, a US study linking e-cigarette use to a rise in smokers quitting was covered widely, including Reuters, ABC News, CBS News and International Business Times ● A JECH study suggesting that dog ownership boosts physical activity in later life generated widespread coverage, including the New York Times, Times of India, The Asian Age and Sky News Australia BMJ Innovative Figure 1 Medical Information App – Health Professional Radio 30/7/2017 The BMJ Analysis: The antibiotic course has had its day Researchers question whether you should really finish your antibiotics – CNN 27/07/2017 Rule that patients must finish antibiotics course is wrong, study says - The Guardian 27/7/2017 BBC Radio 4 Today Programme Interview with author Tim Peto and Helen Stokes-Lampard, RCGP Chair (07.50am) 27/07/2017 Key broadcasts: BBC News Channel, BBC1 Breakfast, BBC1 London Breakfast, BBC2 Newsroom Live, BBC Radio 5 Live Breakfast, BBC Victoria Derbyshire, BBC News at One, Newsday & Newshour (BBC World Service Radio), Good Morning -
NAT TURNER's REVOLT: REBELLION and RESPONSE in SOUTHAMPTON COUNTY, VIRGINIA by PATRICK H. BREEN (Under the Direction of Emory
NAT TURNER’S REVOLT: REBELLION AND RESPONSE IN SOUTHAMPTON COUNTY, VIRGINIA by PATRICK H. BREEN (Under the Direction of Emory M. Thomas) ABSTRACT In 1831, Nat Turner led a revolt in Southampton County, Virginia. The revolt itself lasted little more than a day before it was suppressed by whites from the area. Many people died during the revolt, including the largest number of white casualties in any single slave revolt in the history of the United States. After the revolt was suppressed, Nat Turner himself remained at-large for more than two months. When he was captured, Nat Turner was interviewed by whites and this confession was eventually published by a local lawyer, Thomas R. Gray. Because of the number of whites killed and the remarkable nature of the Confessions, the revolt has remained the most prominent revolt in American history. Despite the prominence of the revolt, no full length critical history of the revolt has been written since 1937. This dissertation presents a new history of the revolt, paying careful attention to the dynamic of the revolt itself and what the revolt suggests about authority and power in Southampton County. The revolt was a challenge to the power of the slaveholders, but the crisis that ensued revealed many other deep divisions within Southampton’s society. Rebels who challenged white authority did not win universal support from the local slaves, suggesting that disagreements within the black community existed about how they should respond to the oppression of slavery. At the same time, the crisis following the rebellion revealed divisions within white society. -
Pacman TEMPLATE
Updated October 2019 National Cardiac Arrest Audit Participating Hospitals The total number of hospitals signed up to participate in NCAA is 194. England Birmingham and Black Country Non-participant New Cross Hospital The Royal Wolverhampton Hospitals NHS Trust Queen Elizabeth Hospital, Birmingham University Hospital Birmingham NHS Foundation Trust Participant Alexandra Hospital Worcestershire Acute Hospitals NHS Trust Birmingham Heartlands Hospital University Hospital Birmingham NHS Foundation Trust City Hospital Sandwell and West Birmingham Hospitals NHS Trust Good Hope Hospital University Hospital Birmingham NHS Foundation Trust Hereford County Hospital Wye Valley NHS Trust Manor Hospital Walsall Healthcare NHS Trust Russells Hall Hospital The Dudley Group of Hospitals NHS Trust Sandwell General Hospital Sandwell and West Birmingham Hospitals NHS Trust Solihull Hospital University Hospital Birmingham NHS Foundation Trust Worcestershire Royal Hospital Worcestershire Acute Hospitals NHS Trust Central England Participant George Eliot Hospital George Eliot Hospital NHS Trust Glenfield Hospital University Hospitals of Leicester NHS Trust Kettering General Hospital Kettering General Hospital NHS Foundation Trust Leicester General Hospital University Hospitals of Leicester NHS Trust Leicester Royal Infirmary University Hospitals of Leicester NHS Trust Northampton General Hospital Northampton General Hospital NHS Trust Hospital of St Cross, Rugby University Hospitals Coventry and Warwickshire NHS Trust University Hospital Coventry University -
Tory Victory an Early Christmas Present for Job-Hunters As Recruitment Picks up JAMES BOOTH Picked up from November, the Growth Was Only Modest
BUSINESS WITH PERSONALITY FREE WILLIE JANUARY, SOLVEDBANISH AVIATION TITAN THE WINTER BLUES WITH A TO STEP DOWN BUMPER WEEKENDP24–25 FROM IAG P5 FRIDAY 10 JANUARY 2020 ISSUE 3,531 CITYAM.COM FREE Sterling slips after Carney IRAN ‘SHOT cuts warning JAMES WARRINGTON @j_a_warrington THE POUND slumped to a near two-week low yesterday after Mark Carney warned that the Bank of England (BoE) could cut interest rates to DOWN’ JET boost the economy. Sterling dropped as much as 0.55 per cent against the dollar to $1.301 after the central bank governor said a cut was possible if weaknesses in the economy looked likely to continue. “With the relatively limited space to cut Bank rate, if evidence builds that the weakness in activity could persist, risk management considerations would favour a relatively prompt response,” • EVIDENCE MOUNTS OVER UKRAINE FLIGHT DOWNED IN TEHRAN Carney said during one of his final speeches before his departure in March. • US OFFICIALS CONVINCED IRANIAN ANTI-AIRCRAFT FIRE TO BLAME In the last two monthly meetings of the Bank of EDWARD THICKNESSE in the crash — said that “the evidence plane burning as it went down. incident. “All indications are that the England’s Monetary Policy AND CATHERINE NEILAN indicates the plane was shot down by an US officials earlier told media outlets plane was shot down accidentally”. Committee, two members Iranian surface-to-air missile”. that the incident was likely a mistake. Ukrainian officials had earlier have voted to cut interest @edthicknesse @CatNeilan Both leaders called for a “full, The crash came shortly after Iran fired demanded to search the crash site after rates, though Carney backed WORLD leaders last night lined up to transparent investigation” into the ballistic missiles at two coalition bases in unverified pictures of missile debris keeping them on hold. -
International Genome-Wide Meta-Analysis Identifies New Primary Biliary Cirrhosis Risk Loci and Targetable Pathogenic Pathways
Dartmouth College Dartmouth Digital Commons Dartmouth Scholarship Faculty Work 9-22-2015 International Genome-Wide Meta-Analysis Identifies New Primary Biliary Cirrhosis Risk Loci and Targetable Pathogenic Pathways Heather J. Cordell Newcastle University Younghun Han Dartmouth College George F. Mells Cambridge University Yafang Li Dartmouth College Gideon M. Hirschfield University of Birmingham Follow this and additional works at: https://digitalcommons.dartmouth.edu/facoa See next page for additional authors Part of the Medicine and Health Sciences Commons Dartmouth Digital Commons Citation Cordell, Heather J.; Han, Younghun; Mells, George F.; Li, Yafang; Hirschfield, Gideon M.; Greene, Casey S.; Xie, Gang; Juran, Brian D.; Zhu, Dakai; Qian, David C.; Floyd, James A.B; Morley, Katherine I.; Prati, Daniele; Lleo, Ana; Cusi, Daniele; Canadian–US PBC Consortium; Italian PBC Genetics Study Group; UK-PBC Consortium; Gershwin, M. Eric; Anderson, Carl A.; Lazaridis, Konstantinos N.; Invernizzi, Pietro; Seldin, Michael F.; Sandford, Richard N.; Amos, Christopher I.; and Siminovitch, Katherine A., "International Genome-Wide Meta-Analysis Identifies New Primary Biliary Cirrhosis Risk Loci and Targetable Pathogenic Pathways" (2015). Dartmouth Scholarship. 2874. https://digitalcommons.dartmouth.edu/facoa/2874 This Article is brought to you for free and open access by the Faculty Work at Dartmouth Digital Commons. It has been accepted for inclusion in Dartmouth Scholarship by an authorized administrator of Dartmouth Digital Commons. For more information, please contact [email protected]. Authors Heather J. Cordell, Younghun Han, George F. Mells, Yafang Li, Gideon M. Hirschfield, Casey S. Greene, Gang Xie, Brian D. Juran, Dakai Zhu, David C. Qian, James A.B Floyd, Katherine I. -
Peer Review Report Southampton Regional Centre and Local District Hospitals ‘Central South Coast’ Paediatric Cystic Fibrosis Network November 2013 1
In partnership with Peer review report Southampton Regional Centre and Local District Hospitals ‘Central South Coast’ Paediatric Cystic Fibrosis Network November 2013 1. Executive summary 1.1 Overview of service page 3 1.2 Good practice examples page 3 1.3 Key recommendations page 3 1.4 Areas for further consideration page 4 2. Performance against the Cystic Fibrosis Trust’s ‘Standards of Care (2011)’ 2.1 Models of care page 5 2.2 Multidisciplinary care page 5 2.3 Multidisciplinary care page 6 2.4 Principles of care page 7 2.5 Delivery of care page 8 2.6 Commissioning page 9 3. UK CF Registry data page 11 4. Delivery against professional standards/guidelines not already assessed 4.1 Consultant page 12 4.2 Specialist nursing page 12 4.3 Physiotherapy page 13 4.4 Dietetics page 13 4.5 Pharmacy page 19 4.6 Psychology page 21 4.7 Social work page 22 5. User feedback page 22 6. Appendices Southampton Children’s Hospital page 23 Poole General Hospital page 42 Queen Alexandra Hospital, Portsmouth page 62 Basingstoke and North Hampshire Hospital page 82 Dorset County Hospital page 103 Salisbury District Hospital page 122 Great Western Hospital, Swindon page 140 Royal Hampshire County Hospital, Winchester page 160 Yeovil District Hospital page 179 St Mary’s Hospital, Isle of Wight page 200 Jersey General Hospital page 219 Princess Elizabeth Hospital, Guernsey page 229 Panel members page 242 1. Executive summary 1.1 Overview of the service The ‘Central South Coast’ paediatric cystic fibrosis network comprises the regional specialist centre at Southampton Children’s Hospital (SCH), nine UK network clinics and patients from Jersey and Guernsey. -
TRUST BOARD MEETING in PUBLIC Wednesday 29 July 2020 at 09:00
TRUST BOARD MEETING IN PUBLIC Wednesday 29 July 2020 At 09:00 To be held via Microsoft Teams Page 1 of 241 Page 2 of 241 TRUST BOARD MEETING IN PUBLIC Wednesday 29th July 2020 09:00 – 13:00 via Microsoft Teams A G E N D A Item Time Item Enclosure Presented No. Y/N by 087.20 09.00 Welcome, Apologies and Declaration of Interests N Chair (to ascertain whether any Member has a conflict of interest with any items on the Agenda) 088.20 09.02 Minutes of the last meeting – 27th May 2020 1 Chair 089.20 09.05 Matters arising/summary of agreed actions 2 Chair 090.20 09.07 Notification of any other business N/A Chair 091.20 09.10 Chair’s opening remarks N/A Chair 092.20 09.15 Chief Executive’s report 3 CEO 093.20 09.40 Staff story N DWOD STRATEGY Implementing a workforce race equality 094.20 10.00 4 DWOD response in the context of COVID-19 Development of Education and Research 095.20 10.10 N CEO Partnerships 096.20 10.25 Isle of Wight NHS Trust partnership 5 DSP 097.20 10.40 Corporate Strategy update 6 DSP 098.20 10.50 Board Assurance Framework 7 DGR 099.20 11.00 Research and innovation 8 MD WORKFORCE AND ORGANISATIONAL DEVELOPMENT Workforce and Organisational Development 100.20 11.10 N** DWOD performance report analysis QUALITY, SAFETY AND PERFORMANCE Quality and Performance Committee feedback • 19th June 2020 o Reporting of Injuries, Diseases and Committee 101.20 11.20 Dangerous Occurrences Regulations 9 Chair o Board Risk Register o Infection Prevention and Control Board Assurance Framework Page 3 of 241 • 22nd July 2020 o Safeguarding Annual Report -
News Consumption in the UK: 2019
News Consumption in the UK: 2019 Produced by: Jigsaw Research Fieldwork dates: November 2018 and March 2019 Published: 24 July 2019 PROMOTING CHOICE • SECURING STANDARDS • PREVENTING HARM 1 Key findings from the report While TV remains the most-used platform for news nowadays by UK adults, usage has decreased since last year (75% vs. 79% in 2018). At the same time, use of social media for news use has gone up (49% vs. 44%). Use of TV for news is much more likely among the 65+ age group (94%), while the internet is the most-used platform for news consumption among 16-24s and those from a minority ethnic background. Fewer UK adults use BBC TV channels for news compared to last year, while more are using social media platforms. As was the case in 2018, BBC One is the most-used news source among all adults (58%), followed by ITV (40%) and Facebook (35%). However, several BBC TV news sources (BBC One, BBC News Channel and BBC Two) have all seen a decrease in use for news compared to 2018. Use of several social media platforms for news have increased since last year (Twitter, WhatsApp, Instagram and Snapchat). There is evidence that UK adults are consuming news more actively via social media. For example, those who access news shared by news organisations, trending news or news stories from friends and family or other people they follow via Facebook or Twitter are more likely to make comments on the new posts they see compared to the previous year. When rated by their users on measures such as quality, accuracy, trustworthiness and impartiality, magazines continue to perform better than other news platforms, followed by TV. -
Trust Board Meeting in Public
TRUST BOARD MEETING IN PUBLIC Wednesday 31 July 2019 At 10:00 VENUE: Oasis Centre, Queen Alexandra Hospital COSHAM Page 1 of 183 Page 2 of 183 TRUST BOARD MEETING IN PUBLIC Wednesday 31st July 2019 10:00 – 14.45 Oasis Centre, Queen Alexandra Hospital, Southwick Hill Road, Cosham, Portsmouth, PO6 3LY A G E N D A Item Time Item Enclosure Presented No. Y/N & by Number Presentation: CHKS Top 40 Hospitals Award 178.19 10.20 Welcome, Apologies and Declaration of N Chair Interests (to ascertain whether any Board Member has any conflict of interest with any items on the Agenda) 179.19 10.25 Patient Story N 180.19 10.50 Minutes of the last meeting – 26th June 2019 1 Chair 181.19 10.55 Matters Arising/Summary of agreed actions 2 Chair 182.19 11.00 Notification of any other business N/A Chair 183.19 11.05 Chair’s opening remarks N/A Chair 184.19 11.15 Chief Executive’s Report 3 CEO WORKFORCE AND ORGANISATIONAL DEVELOPMENT Workforce and Organisational Development Committee feedback Committee 185.19 11.40 4 19th July 2019 (for discussion) Chair 24th June 2019 (for information) Workforce and Organisational Development 186.19 11.50 N** DWOD performance report analysis 187.19 12.10 Learning and Development – Annual Report 5 DWOD QUALITY & SAFETY Committee 188.19 12.20 Quality and Performance Committee 6 Chair feedback 189.19 12.30 Safety, quality and operational performance N** COO / MD report analysis 190.19 13.10 Freedom to Speak Up – quarterly report 7 DGR Page 3 of 183 191.19 13.20 National Inpatient Survey 8 CN FINANCE AND INFRASTRUCTURE Finance -
The North East Regional Assembly Campaign
The North East Regional Assembly Campaign: A Media Content Analysis by the Loughborough University Communication Research Centre for the Electoral Commission 28th January 2005 1 Contents Executive Summary 2-4 Introduction and methodological note 5-7 Quantitative Content Analysis 1. Sample media 8-9 2. Amount of coverage 9-13 3. Balance of reporting 13-22 4. Media agenda and themes 22-28 5. Framing the campaign 28-31 Qualitative Review 6. Pre-campaign 31-33 7. Internet presence 33-34 8. Local broadcasting 35-37 9. National broadcasting 37-39 10. Local press 40-45 11. Representing public opinion 46-48 12. National press 48-50 Conclusion 51-52 References 2 Executive summary This comprehensive audit of local and national newspaper and broadcast coverage of the referendum for a Regional Assembly in the North East points to the following main conclusions. Despite the major nationwide constitutional implications of the proposals, the referendum campaign did not excite intensive and sustained media interest throughout the campaign period, nor in the months preceding it. Not surprisingly, levels of media attention were higher in the local media based in the North East than in the national media. However, there were also significant differences across the North East media in the amount of copy- dedicated to the topic. Levels of press coverage in Durham, Teeside and Northumberland were lower than those found within Tyne and Wear. Furthermore, there was a considerable variation within the Tyne and Wear area, where Newcastle based news organisations gave appreciably greater prominence to the devolution vote and debate than others in the region. -
The Royal Bank of Scotland Hospital List for Gold Option
GEN3461_97000805.qxp:GEN3461_97000805 13/7/12 16:13 Page 1 The Royal Bank of Scotland Hospital List for Gold Option England Cheshire Bedfordshire Cheadle BMI The Alexandra Hospital Chester Nuffield Health Grosvenor Hospital Bedford Bedford Hospital (Chester) Biddenham BMI The Manor Hospital Crewe BMI The South Cheshire Private Luton Luton & Dunstable Hospital - Cobham Hospital Clinic Macclesfield Spire Regency Hospital Berkshire Warrington Spire Cheshire Hospital Reading Berkshire Independent Hospital Cleveland Spire Dunedin Hospital Norton Nuffield Health Tees Hospital Slough Spire Thames Valley Hospital Wexham Park Hospital Cornwall - Paragon Suite Truro Duchy Hospital Windsor BMI The Princess Margaret Hospital Cumbria Bristol Carlisle Caldew Hospital Bristol Spire Bristol Hospital Whitehaven West Cumberland Hospital Eye Hospital - Cumbrian Clinic General Hospital Nuffield Health Bristol Hospital Derbyshire Royal Hospital for Sick Children Derby Nuffield Health Derby Hospital Royal Infirmary Devon Buckinghamshire Barnstaple North Devon District Hospital Aylesbury Stoke Mandeville Hospital - Roborough Suite Great Missenden BMI The Chiltern Hospital Exeter Nuffield Health Exeter Hospital High Wycombe BMI The Shelburne Hospital Royal Devon & Exeter Hospital Plymouth Derriford Hospital - The Meavy Clinic Milton Keynes BMI The Saxon Clinic Nuffield Health Plymouth Hospital Cambridgeshire Torquay Mount Stuart Hospital Cambridge Addenbrookes Hospital Spire Cambridge Lea Hospital Dorset Nuffield Health Cambridge Hospital Bournemouth Nuffield Health Bournemouth