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Future-Oriented Medicine: the Language of Cells New Dimensions: Riding the Comet Discovering Asia: All with the Light of a Matchstick Would You Like to Know More?

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Future-Oriented Medicine: the Language of Cells New Dimensions: Riding the Comet Discovering Asia: All with the Light of a Matchstick Would You Like to Know More? Would you like to know more? The Magazine from Carl Zeiss Issue 19 3/ 2008 Innovation – The Magazine from Carl Zeiss can be found on the Internet at www.zeiss.com/innovation Would you like more Innovation? Has your address changed? Future-oriented Medicine: The Language of Cells New Dimensions: Riding the Comet Discovering Asia: All with the Light of a Matchstick Would you like to know more? Please send me the following publications: “Insights” image brochure 2006/07 Annual Report h German h German h English h English Company/Institute/Organization Last name, First name Position Street address Carl Zeiss AG Innovation Editorial Staff City, Zip/Postal code Renate König Country 73446 Oberkochen Germany Email If known: subscription or customer number Fax: +49 (0)7364 20-3370 Would you like more Innovation? Please send me the following publications: Innovation customer magazine h German h Once h English h Regularly Company/Institute/Organization Neural representation of learning processes at the synapsis Last name, First name The genetic expression of the cytoplasmatic Position protein (Arc) associated with learning is induced in a subpopulation of pyramidal Street address Carl Zeiss AG neurons through research into a new en- Innovation Editorial Staff vironment. The specificity and necessity of City, Zip/Postal code Renate König this Arc expression for learning processes were verified in previous papers. Additional Country 73446 Oberkochen studies have shown that Arc RNAs specifi- Germany cally localize in activated, dendritic sub- Email regions after electrical stimulation. Fax: +49 (0)7364 20-3370 If known: subscription or customer number All dendritic trees can be displayed using transgenic mice forming yellow fluorescent protein (YFP) in neuron subpopulations. An optimized method of fluorescence in situ Has your address changed? hybridization (FISH) permits the simultane- ous display of Arc and the endogenous YFP signal (e.g. activated neuron subpopula- tions in the hippocampus, see picture on page 16). Efforts will be made to identify synaptic connections and changes using the automated recognition of the dendrite Previous address: New address: structure and the localization of Arc RNA and the Arc protein depending on the behavioral process. Company/Institute/Organization Dr. Michael Calhoun, Molecular Imaging Last name, First name Group, Hertie Institute, Tübingen (http://www.hih-tuebingen.de). Position Daniel Eicke, Data Analysis and Visualization Street address Carl Zeiss AG Innovation Editorial Staff City, Zip/Postal code Renate König Country 73446 Oberkochen Germany Email Fax: +49 (0)7364 20-3370 If known: subscription or customer number Editorial Dear Readers, It does not even take a trend researcher like Matthias Horx to recognize that health is a subject that truly deserves the label “megatrend.” We all know how miserable we feel even if we are only suffering from a common cold or the odd headache. However, what a diagnosis like cancer or Alzheimer means for the person affected and for their environment can only really be understood by someone who has experienced these diseases at close hand. In the almost two-and-a-half millennia that have passed since the discoveries of Hippocrates of Kos, many pioneering advances have been made in the field of medicine. Some of these were inextricably linked to instruments from Carl Zeiss. Something which has not changed in all these years, however, is that a disease cannot be diagnosed until it has actually broken out. With molecular imaging, medicine and medical technology will experi- ence a real revolution: in several years, they will help us to reach a stage where we can find the causes of illness and therefore diagnose diseases long before their outbreak. This will increase the chances of effective therapy and cure. Therefore, Carl Zeiss has joined the Molecular Imaging Technology Initiative launched by the German government and has become one of five founding partners. As a leading company in the field of optics and medical technology, it is our goal to transfer new molecular imaging techniques from research to their practical use in laboratories, doctors' offices and hospitals and to safeguard Germany’s position as a leading healthcare market with the aid of this future-oriented technology. Optical technologies will be key pacemakers in this process. I hope this issue of Innovation finds you in the best of health! Best wishes Dr. Michael Kaschke Member of the Carl Zeiss AG Executive Board Innovation 19, / 2008 Contents Editorial 3 Panorama 6 Silent Observers 10 The Hobby of Birdwatching Cover Story: Future-oriented Medicine The Language of Cells 14 ”A Revolution in Medicine“ 22 An Interview with Dr. Michael Kaschke The Direction of Research 23 14 “Nowhere Near the End of Our Opportunities“ 26 It is considered a revolution in medicine: molecular imaging Guest Article by Dr. Andreas Wunder helps us to better understand the human body. Essay 50 A Journey Inside Innovation 19, / 2008 Features See in the Dark 36 Discovering Complex Defects in Vision 38 Cover Story: Report: New Dimensions New projector systems Future-oriented Medicine in planetariums invite Riding the Comet 30 the audience to take part in virtual adven- 30 tures into the dark An Eagle Eye for the Nano World 34 depths of the cosmos. Report: Discovering Asia Images from another world – Mongolia. All with the Light of a Matchstick 40 The Right to Sight 48 Service Preview 54 Legal information 54 40 Innovation 19, / 2008 Panorama Watching videos at total ease – with the cinemizer from Carl Zeiss. Movies for Your Vest Pocket The cinemizer from Carl Zeiss puts movies at the end of your nose A long-distance flight, an awful TV lineup at a hotel, a uninvited guests such as the person sitting next to you. late train – business trips can be boring. With the Optimized for iPod with video, the cinemizer can none- cinemizer, Carl Zeiss has landed a winner: an innovation theless be connected to other devices, such as your that puts movies from portable players right in front of home DVD player or a game console, thanks to an addi- your eyes and looks just like a pair of sunglasses. The tional jack. Gamers and movie enthusiasts can indulge in cinemizer simulates a 11 cm display at a distance of their passion without turning other family members into two meters, giving the wearer an authentic movie feel- unwilling participants. The cinemizer celebrated its ing with a private viewing. The smooth adjustment pos- world premiere at this year’s MacWorld Expo in sibilities on both sides for different prescriptions enable San Francisco in January. people with visual defects to also enjoy this exclusive experience. Loudspeakers integrated into the earpieces ensure a good sound. The high-performance battery guarantees four hours of movie enjoyment. You can watch your favorite videos and movies anytime, any- where. Simply connect the cinemizer to the iPod using the practical clip or connect it to another mobile video player via a cable. The main advantage: there are no Innovation 19, / 2008 Wonderfully Fossilized Movies and Pixels Living deep-sea oyster discovered The ARRI AG can do both: analog and digital Successfully hidden: a primitive oyster. ARRIFLEX 35II, 1946 Oysters are sometimes located in the strangest of places. Movie buffs prick up their ears with great interest when Not only in Frank Schatzing’s book “The Swarm”, but they hear that ARRI is now building digital cameras. also in the ocean. The deep sea oyster hid under over- The company that has been working with Carl Zeiss for hanging rocks for decades so successfully from the drag- 0 years is gaining a second foothold with this new nets of researchers that it was considered extinct until technology. the 190s. By chance, paleontologist Max Wisshak dis- covered a significant cluster of hundreds of oysters near In 191 August Arnold and Robert Richter founded the the Azores at a depth of 00 meters on a video taken firm “Arnold & Richter Cine Technik” in a former shoe- with his research submarine Lula. At the site of filming, maker’s workshop in Munich. Today, ARRI is the world he discovered living deep-sea oysters and thus a scien- market leader in the field of analog movie cameras. The tific sensation. The primitive oyster was probably 100 new digital technology is not intended to replace the years old and had annual rings made of lime. Wisshak proven analog technology, but to supplement it. In the analyzed these layers of lime under the microscope, a future, other magnificent movies such as The Lord of the ZEISS Axiophot. From their composition, he was able to Rings and Perfume will also be filmed with analog cam- identify fluctuations in the water temperature and other eras. However, digital cameras offer new possibilities. environmental parameters such as nutrient content. “We are utilizing these capabilities,“ says ARRI Product He is currently researching how these oysters can be Manager Marc Shipman-Müller, “but, of course, we are used as a climate archive for the North Atlantic. continuing to build cameras for 1 and millimeter film.“ Cancer Research at Its Best Carl Zeiss opens application center at the German Cancer Research Center onset of the disease and to determine risk factors. With the opening of the application center last summer, Carl Zeiss is supporting the research work of the DKFZ at the technology park in Heidelberg which is one of Germa- ny’s most important biotechnology locations and one of the global leaders. Research can be performed on com- plex dynamic processes in the lab rooms with a laser scanning microscope, high-quality light and stereo mi- croscopes and automated microscope systems. Scientists develop new approaches for the prevention, diagnosis Dynamic cell processes under the microscope. and treatment of cancer based on the results of these examinations.
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