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Evaluation of in Silico Approach for Prediction of Presence of Opioid Peptides in Wheat
Evaluation of in silico approach for prediction of presence of opioid peptides in wheat This is the Accepted version of the following publication Garg, Swati, Apostolopoulos, Vasso, Nurgali, Kulmira and Mishra, Vijay Kumar (2018) Evaluation of in silico approach for prediction of presence of opioid peptides in wheat. Journal of Functional Foods, 41. 34 - 40. ISSN 1756-4646 The publisher’s official version can be found at https://www.sciencedirect.com/science/article/pii/S1756464617307454 Note that access to this version may require subscription. Downloaded from VU Research Repository https://vuir.vu.edu.au/36577/ 1 1 Evaluation of in silico approach for prediction of presence of opioid peptides in wheat 2 gluten 3 Abstract 4 Opioid like morphine and codeine are used for the management of pain, but are associated 5 with serious side-effects limiting their use. Wheat gluten proteins were assessed for the 6 presence of opioid peptides on the basis of tyrosine and proline within their sequence. Eleven 7 peptides were identified and occurrence of predicted sequences or their structural motifs were 8 analysed using BIOPEP database and ranked using PeptideRanker. Based on higher peptide 9 ranking, three sequences YPG, YYPG and YIPP were selected for determination of opioid 10 activity by cAMP assay against µ and κ opioid receptors. Three peptides inhibited the 11 production of cAMP to varied degree with EC50 values of YPG, YYPG and YIPP were 5.3 12 mM, 1.5 mM and 2.9 mM for µ-opioid receptor, and 1.9 mM, 1.2 mM and 3.2 mM for κ- 13 opioid receptor, respectively. -
(12) United States Patent (10) Patent No.: US 9.421,180 B2 Zielinski Et Al
USOO9421 180B2 (12) United States Patent (10) Patent No.: US 9.421,180 B2 Zielinski et al. (45) Date of Patent: Aug. 23, 2016 (54) ANTIOXIDANT COMPOSITIONS FOR 6,203,817 B1 3/2001 Cormier et al. .............. 424/464 TREATMENT OF INFLAMMATION OR 6,323,232 B1 1 1/2001 Keet al. ............ ... 514,408 6,521,668 B2 2/2003 Anderson et al. ..... 514f679 OXIDATIVE DAMAGE 6,572,882 B1 6/2003 Vercauteren et al. ........ 424/451 6,805,873 B2 10/2004 Gaudout et al. ....... ... 424/401 (71) Applicant: Perio Sciences, LLC, Dallas, TX (US) 7,041,322 B2 5/2006 Gaudout et al. .............. 424/765 7,179,841 B2 2/2007 Zielinski et al. .. ... 514,474 (72) Inventors: Jan Zielinski, Vista, CA (US); Thomas 2003/0069302 A1 4/2003 Zielinski ........ ... 514,452 Russell Moon, Dallas, TX (US); 2004/0037860 A1 2/2004 Maillon ...... ... 424/401 Edward P. Allen, Dallas, TX (US) 2004/0091589 A1 5, 2004 Roy et al. ... 426,265 s s 2004/0224004 A1 1 1/2004 Zielinski ..... ... 424/442 2005/0032882 A1 2/2005 Chen ............................. 514,456 (73) Assignee: Perio Sciences, LLC, Dallas, TX (US) 2005, 0137205 A1 6, 2005 Van Breen ..... 514,252.12 2005. O154054 A1 7/2005 Zielinski et al. ............. 514,474 (*) Notice: Subject to any disclaimer, the term of this 2005/0271692 Al 12/2005 Gervasio-Nugent patent is extended or adjusted under 35 et al. ............................. 424/401 2006/0173065 A1 8/2006 BeZwada ...................... 514,419 U.S.C. 154(b) by 19 days. 2006/O193790 A1 8/2006 Doyle et al. -
Phytochemical Analysis and Antimicrobial Activity of Myrcia Tomentosa (Aubl.) DC
molecules Article Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves Fabyola Amaral da Silva Sa 1,3, Joelma Abadia Marciano de Paula 2, Pierre Alexandre dos Santos 3, Leandra de Almeida Ribeiro Oliveira 3, Gerlon de Almeida Ribeiro Oliveira 4, Luciano Morais Liao 4 , Jose Realino de Paula 3,* and Maria do Rosario Rodrigues Silva 1,* 1 Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia 74605-050, Brazil; [email protected] 2 Unit of Exact and Technologic Sciences, Goias State University, Anápolis 75132-400, Brazil; [email protected] 3 Faculty of Pharmacy, Federal University of Goias, Goiânia 74605-170, Brazil; [email protected] (P.A.d.S.); [email protected] (L.d.A.R.O.) 4 Chemistry Institute, Federal University of Goiás, Goiânia 74690-900, Brazil; [email protected] (G.d.A.R.O.); [email protected] (L.M.L.) * Correspondence: [email protected] (J.R.d.P.); [email protected] (M.d.R.R.S.); Tel.: +55-62-3209-6127 (M.d.R.R.S.); Fax: +55-62-3209-6363 (M.d.R.R.S.) Academic Editor: Isabel C. F. R. Ferreira Received: 23 May 2017; Accepted: 29 June 2017; Published: 4 July 2017 Abstract: This work describes the isolation and structural elucidation of compounds from the leaves of Myrcia tomentosa (Aubl.) DC. (goiaba-brava) and evaluates the antimicrobial activity of the crude extract, fractions and isolated compounds against bacteria and fungi. Column chromatography was used to fractionate and purify the extract of the M. tomentosa leaves and the chemical structures of the compounds were determined using spectroscopic techniques. -
Guava (Psidium Guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities
foods Review Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities Manoj Kumar 1 , Maharishi Tomar 2, Ryszard Amarowicz 3,* , Vivek Saurabh 4 , M. Sneha Nair 5, Chirag Maheshwari 6, Minnu Sasi 7, Uma Prajapati 4, Muzaffar Hasan 8, Surinder Singh 9, Sushil Changan 10 , Rakesh Kumar Prajapat 11, Mukesh K. Berwal 12 and Varsha Satankar 13 1 Chemical and Biochemical Processing Division, ICAR—Central Institute for Research on Cotton Technology, Mumbai 400019, India; [email protected] 2 ICAR—Indian Grassland and Fodder Research Institute, Jhansi 284003, India; [email protected] 3 Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Str., 10-748 Olsztyn, Poland 4 Division of Food Science and Postharvest Technology, ICAR—Indian Agricultural Research Institute, New Delhi 110012, India; [email protected] (V.S.); [email protected] (U.P.) 5 Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad 121004, Haryana, India; [email protected] 6 Department of Agriculture Energy and Power, ICAR—Central Institute of Agricultural Engineering, Bhopal 462038, India; [email protected] 7 Division of Biochemistry, ICAR—Indian Agricultural Research Institute, New Delhi 110012, India; [email protected] 8 Agro Produce Processing Division, ICAR—Central Institute of Agricultural Engineering, Citation: Kumar, M.; Tomar, M.; Bhopal 462038, India; [email protected] 9 Amarowicz, R.; Saurabh, V.; Nair, Dr. S.S. Bhatnagar University Institute of Chemical Engineering and Technology, Panjab University, Chandigarh 160014, India; [email protected] M.S.; Maheshwari, C.; Sasi, M.; 10 Division of Crop Physiology, Biochemistry and Post-Harvest Technology, ICAR—Central Potato Research Prajapati, U.; Hasan, M.; Singh, S.; Institute, Shimla 171001, India; [email protected] et al. -
Phytopharmacological Overview of Psidium Guajava Linn
Pharmacogn. J. Review Article A multifaceted peer reviewed journal in the field of Pharmacognosy and Natural Products www.phcogfirst.com/phcogj Phytopharmacological overview of Psidium guajava Linn. Vijaya Anand1, Manikandan2, Vijaya Kumar2, Sampath Kumar3, Pushpa4, Agaath Hedina1 1Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore–641 046, Tamil Nadu, INDIA. 2Department of Biochemistry, M.I.E.T. Arts and Science College, Tiruchirappalli–620 007, Tamil Nadu, INDIA. 3Department of Chemistry and Biosciences, SASTRA University, Kumbakonam–612 001, Tamil Nadu, INDIA. 4Department of Microbiology, Cauvery College for Women, Tiruchirappalli–620 018, Tamil Nadu, INDIA. ABSTRACT Psidium guajava Linn. possesses useful medicinal benefits. It has been recognized as the medicinally essential phytoconstituents, such as pheno- Corresponding author: lic, flavonoid and carotenoid. Numerous pharmacological investigation have Dr. A. Vijaya Anand, confirmed that the ability of this plant is to exhibit antimicrobial, antidia- Associate Professor and Head, Department of Human Genetics and betic, cardioprotective, neuroprotective, hepatoprotective, antioxidant and Molecular Biology, Bharathiar University, Coimbatore–641 046, anticancer activities and it supports the traditional uses. This is a compre- Tamil Nadu, INDIA. hensive of the phytoconstituents and pharmacological benefits. Mobile: +91 9842525830 Key words: Psidium guajava, Antimicrobial, Antidiabetic, Antioxidant, Hep- E-mail: [email protected] atoprotective, Anticancer. DOI: 10.5530/pj.2016.4.3 INTRODUCTION (9Z)-, (13Z)-, and (15Z)-lycopene, (all-E,3R)-beta-cryptoxanthin, (all- E, 3R)-rubixanthin, (all-E,3S,5R,8S)-cryptoflavin, (all-E,3R,3’R, 6’R)- Psidium guajava Linn. is commonly called guave, goyave in French; lutein, (all-E,3S,5R,6R,3’S,5’R,8’R)-, and (all-E,3S,5R,6R,3’S, 5’R,8’S)- guave, guavenbaum, in German; banjiro in Japanese; goiaba, in Portu- neochrome.9 Guavanoic acid, guavacoumaric acid, 2α-hydroxyursolic 1 gal; arac¸ guaiaba in Brazil; and guava in English. -
Bibliography Section
ISSN 0021-9673 VOL. 524 NO.6 DECEMBER 21, 1990 THIS ISSUE COMPLETES VOL. 524 Bibliography Section EDITORS R. W. Giese (Boston, MA) J. K. Haken (Kensington, N.S.W.) K. Macek (Prague) L. R. Snyder (Orinda, CA) EDITOR, SYMPOSIUM VOLUMES, E. Heitmann (Orinda, CAl EDITORIAL BOARD D. W. Armstrong (Rolla. MO) W. A. Aue (Halifax) P. Bocek (Brno) A. A. Boulton (Saskatoon) P. W. Carr (Minneapolis. MN) N. H. C. Cooke (San Ramon. CAl V. A. Davankov (Moscow) Z. Deyl (Prague) S. Dilli (Kensington. N.S.W.) H. Engelhardt (Saarbrucken) F. Erni (Basle) M. B. Evans (Hatfield) J. L. Glajch (N. Billerica. MA) G. A. Guiochon (Knoxville. TN) P. R. Haddad (Kensington. N.S.w.) I. M. Hais (Hradec Kralove) W. S. Hancock (San Francisco, CAl S. Hjerten (Uppsala) Cs. Horvath (New Haven, CT) J. F. K. Huber (Vienna) K.-P. Hupe (Waldbronn) 1. W. Hutchens (Houston. TX) J. Janak (Brno) P. Jandera (Pardubice) B. L. Karger (Boston. MA) E. sz. Kovats (Lausanne) A. J. P. Martin (Cambridge) L. W. McLaughlin (Chestnut Hill, MA) E D. Morgan (Keele) J. D. Pearson (Kalamazoo. MI) H. Poppe (Amsterdam) F. E. Regnier (West Lafayette. IN) P. G. Righetti (Milan) P. Schoenmakers (Eindhoven) G..Schomburg (MulheimjRuhr) R. Schwarzeobach (Dubendorf) R. E. .s~OlJ~ (West Lafayette. IN) -A.JVI. Siouffi'(Marseille) D. J. Strydom' (Boston, MA) K. K. Ugger (Mainz) R. VerP'l0rte (Leideo). Gy. Vigh tColiege Statioo, TX) oJ. T vtiMpo (E~SI ta~sihg. MI) B. D. ~&terlunp ,(UPl1sala) EDITORS, BIBLIOGRAPHY SECTION z. Deyl (Prague), J. Janak (Brno). V. Schwarz (Prague), K Ma~ek (Prague) ELSEVIER JOURNAL OF CHROMATOGRAPHY Scope. -
Efficacy and Safety of Gluten-Free and Casein-Free Diets Proposed in Children Presenting with Pervasive Developmental Disorders (Autism and Related Syndromes)
FRENCH FOOD SAFETY AGENCY Efficacy and safety of gluten-free and casein-free diets proposed in children presenting with pervasive developmental disorders (autism and related syndromes) April 2009 1 Chairmanship of the working group Professor Jean-Louis Bresson Scientific coordination Ms. Raphaëlle Ancellin and Ms. Sabine Houdart, under the direction of Professor Irène Margaritis 2 TABLE OF CONTENTS Table of contents ................................................................................................................... 3 Table of illustrations .............................................................................................................. 5 Composition of the working group ......................................................................................... 6 List of abbreviations .............................................................................................................. 7 1 Introduction .................................................................................................................... 8 1.1 Context of request ................................................................................................... 8 1.2 Autism: definition, origin, practical implications ........................................................ 8 1.2.1 Definition of autism and related disorders ......................................................... 8 1.2.2 Origins of autism .............................................................................................. 8 1.1.2.1 Neurobiological -
Enzyme-Mediated Regioselective Acylations of Flavonoid Glycosides
FABAD j. P/ıarrıı. Sci., 20, 55-59, 1995 RESEARCH AR.TICLES /BİLİMSEL ARAŞTIRMALAR Enzyme-Mediated Regioselective Acylations of Flavonoid Glycosides Ihsan ÇALIŞ*t, Meltem ÖZİPEK*, Mcvlüt ERTAN**, Petcr RÜEDI*** Abstract: Flavonoid glycosides, xaııtlıorlıanınins B, C, a11d ru Flavouoit Glikozitlerirıiu Eıızinıatik Açilleunıesi tin lıaı~ been acylated by the catalytic actioıı of the protense sııbtilisi11 in aıılrydrous pyridine. The acylatioıı occııred ıoitlı Özet: Flavonoit glikozitlerinden ksantornnınin B, C ve rutin, lıiglı yield roitlı rutin giving a single monoester 011 its glııcose anlıidr piridinde proteaz subtilisin ile açillenmiştir. rııoicty Reaksiyo11 slıoıoing excellent selectivity. But it occııred witlı loıv 011 yield the galactose moiety of tJıe two flavonoid triglycosides. sonucunda, glukoz üzerinden rutinin nıonoesteri yüksek vcrinı Ie elde edilirken, galaktoz üzerinden flavonoit triglikozitleriııiıı Key words : Acylated f!avonoid glycosides, enzyrnatic acy- esterleri çok düşük verirnle elde edilmiştir. lation. Received : 29.6.1994 Anahtar kelinıeler : Ester flavonoit glikozit/er, enzhnatik Accepted : 19.1.1995 açillenıe Introduction the regioselective acylation of polyhydroxylated cornpounds3.4. Flavonoid glycosides are widely distributed in na ture and often found as esters with different acids at We now report on the substilisin-catalyzed esterifica specific positions of their sugar moieties. Besides tion of two flavonoid triglycosides isolated from these esters, the cinnamoyl, p-coumaroyl and feru Rhamnus petiolaris -
Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits
molecules Review Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits 1,2 2, 1,3 1, Bianca Eugenia S, tefănescu , Katalin Szabo * , Andrei Mocan and Gianina Cri¸san * 1 Department of Pharmaceutical Botany, “Iuliu Hat, ieganu” University of Medicine and Pharmacy, 23, Ghe. Marinescu Street, 400337 Cluj-Napoca, Romania; [email protected] (B.E.S, .); [email protected] (A.M.) 2 Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, CaleaMănă¸stur3-5, 400372 Cluj-Napoca, Romania 3 Laboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania * Correspondence: [email protected] (K.S.); [email protected] (G.C.) Received: 13 April 2019; Accepted: 22 May 2019; Published: 29 May 2019 Abstract: Some species of the Ericaceae family have been intensively studied because of the beneficial health impact, known since ancient times, of their chemical components. Since most studies focus on the effects of fruit consumption, this review aims to highlight the phenolic components present in the leaves. For this purpose, five species from Ericaceae family (bilberry—Vaccinium myrtillus L., lingonberry—V. vitis-idaea L., bog bilberry—V. uliginosum L., blueberry—V. corymbosum L. and bearberry—Arctostapylos uva-ursi L.) were considered, four of which can be found in spontaneous flora. The chemical composition of the leaves revealed three major phenolic compounds: chlorogenic acid, quercetin and arbutin. The health promoting functions of these compounds, such as antioxidant and anti-inflammatory properties that could have preventive effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity, have been exemplified by both in vitro and in vivo studies in this review. -
Opioid Peptides in Peripheral Pain Control
Review Acta Neurobiol Exp 2011, 71: 129–138 Opioid peptides in peripheral pain control Anna Lesniak*, Andrzej W. Lipkowski Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw; *Email: [email protected] Opioids have a long history of therapeutic use as a remedy for various pain states ranging from mild acute nociceptive pain to unbearable chronic advanced or end-stage disease pain. Analgesia produced by classical opioids is mediated extensively by binding to opioid receptors located in the brain or the spinal cord. Nevertheless, opioid receptors are also expressed outside the CNS in the periphery and may become valuable assets in eliciting analgesia devoid of shortcomings typical for the activation of their central counterparts. The discovery of endogenous opioid peptides that participate in the formation, transmission, modulation and perception of pain signals offers numerous opportunities for the development of new analgesics. Novel peptidic opioid receptor analogs, which show limited access through the blood brain barrier may support pain therapy requiring prolonged use of opioid drugs. Key words: immune cells, opioid peptides, pain, peripheral analgesia Abbreviations: β-FNA - β-funaltrexamine, BBB - blood-brain-barrier, CGRP - calcitonin gene-related peptide, CFA - complete Freund adjuvant, CNS - central nervous system, CRF - corticotropin releasing factor, CYP - cyprodime, DAGO - [Tyr-D-Ala- Gly-Me-Phe-Gly-ol]-enkephalin, DAMGO - [D-Ala2, N-MePhe4, Gly-ol]-enkephalin, DOR - delta opioid receptor, DPDPE - [D-Pen2,5]-enkephalin, DRG - dorsal root ganglion, EM-1 - endomorphin 1, EM-2 - endomorphin 2, KOR - kappa opioid receptor, MOR - mu opioid receptor, NLZ – naloxonazine, NTI - naltrindole, NLXM - naloxone methiodide; nor-BNI – nor-binaltorphimine, PDYN - prodynorphin, PENK - proenkephalin, PNS - peripheral nervous system, POMC - proopiomelanocortin INTRODUCTION ic pain. -
Chemical Characterization and Opioid Activity of an Exorphin Isolated from in Vivo Digests of Casein
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Volume 196, number2 FEBS 3363 February 1986 Chemical characterization and opioid activity of an exorphin isolated from in vivo digests of casein Hans Meisel Institut fir Chemie und Physik der Bundesanstalt fzZr Milchforschung, 2300 Kiel, FRG Received 17 October 1985; revised version received 4 December 1985 The in vivo formation of an opioid peptide (exorphin) derived from p-casein has been proved for the first time. It was isolated from duodenal thyme of minipigs after feeding with the milk protein casein. The exorphin has been identified as a /?-casein fragment by end-group determinations and qualitative amino acid analysis of the purified peptide. This peptide, named /I-casomorphin-l l, displayed substantial opioid activity in an opiate receptor-binding assay. Exorphin Casomorphin @Casein (Duodenal digest) Opioid activity 1. INTRODUCTION cipitated casein (Biogen-~asein, Bayr. Milchver- sorgung, N~rnberg) after overnight fasting. Post- The existence of opioid peptides has been de- prandial duodenum samples were taken for 8 h, scribed in partial enzymatic digests of proteins frozen immediately in liquid nitrogen and freeze- derived from foodstuffs [l-3]. These peptides are dried. A control experiment was performed after called exorphins because of their exogenous origin feeding with a maize starch diet composed as in [9] and morphine-like activities. without casein. Such opioid peptides have been discovered re- The extraction of 110 g freeze-dried duodenal cently in enzymatic digests of whole bovine casein thyme from 5 collection periods with chloroform/ and were designated as Bcasomorphins because methanol (65 : 35, v/v), and the following batchwise their sequences identified them as fragments of adsorption/desorption procedure was performed bovine fl-casein [4]. -
In Silico Approach of Potential Phytochemical Inhibitor From
In Silico Approach of Potential Phytochemical Inhibitor from Moringa oleifera, Cocos nucifera, Allium cepa, Psidium guajava, and Eucalyptus globulus for the treatment of COVID-19 by Molecular Docking Ika Nur Fitriani ( [email protected] ) Universitas Islam Negeri Walisongo Semarang Wiji Utami Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi Adi Tiara Zikri Universitas Gadjah Mada Pugoh Santoso Kinki Daigaku Kyushu Tanki Daigaku Research Keywords: covid-19, in-silico, molecular docking, Moringa oleifera, Allium cepa, Cocos nucifera, Psidium guajava, Eucalyptus globulus Posted Date: July 23rd, 2020 DOI: https://doi.org/10.21203/rs.3.rs-42747/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/25 Abstract Background Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2. COVID-19 has devastating effects on people in all countries and getting worse. We aim to investigate an in-silico docking analysis of phytochemical compounds from medicinal plants that used to combat inhibition of the COVID-19 pathway. There are several phytochemicals in medicinal plants, however, the mechanism of bioactive compounds remains unclear. These results are obtained from in silico research provide further information to support the inhibition of several phytochemicals. Methods Molecular docking used to determine the best potential COVID-19 M pro inhibitor from several bioactive compounds in Moringa oleifera, Allium cepa, Cocos nucifera, Psidium guajava, and Eucalyptus globulus. Molecular docking was conducted and scored by comparison with standard drugs remdesivir. ADME properties of selected ligands were evaluated using the Lipinski Rule. The interaction mechanism of the most recommended compound predicted using the STITCH database.