January, 2000 number 105 January, 2000 number 105

TOKYO KASEI KOGYO CO.,LTD. International Sales Department 3-1-13,Nihonbashi-honcho,Chuo-ku,Tokyo,103-0023 Japan Tel:+81-3-3278-8153 Fax:+81-3-3278-8008 http://www.tokyokasei.co.jp

CONTENTS

Contribution : The development of new chemistry on multiple-bond compounds with heavier main group elements Renji Okazaki, Professor, Faculty of Science, Japan Women's University - - - - - 2

Chemicals Note : The Suzuki Reaction in Biaryl Synthesis Kayo Ishikawa, Reagent Development Department, Tokyo Kasei Kogyo Co., Ltd. - - - - 16 for Synthesis Anti-Selective Asymmetric Aldol Reaction ------21 Ketene Equivalent ------22 Synthesis of 3-Substituted Indoles Useful Pd(ll) Catalyst for Cross Coupling Reactions ------23 Useful Phosphine Ligand Chiral Ligands ------24 Non-Coordinative Counter Anion ------25 for Analysis Lithium Ion-Selective Electrode ------25

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Contribution The development of new chemistry on multiple-bond compounds with heavier main group elements

Renji Okazaki, Professor, Faculty of Science, Japan Women’s University

1. Introduction

The multiple-bond compounds including second period elements such as olefin, imine (Schiff base), ketone, acetylene, nitrile etc. are stable compounds and play a very important role in organic chemistry. Contrary to this, multiple-bond compounds containing elements from the third period onward (named as heavier main group elements), have long bond distances and their π bond energy generated through the overlapping of p-orbitals is low so that they are extremely unstable. Examples of π bond energy are shown in Table 1.1

C=C 65 N=N 60 C=O 77 C=Si 38 P=N 44 C=S 52 Si=Si 25 P=P 34 Si=S 50

Table 1. π bond energy associated with double-bond including the multiple-bond of heavier main group elements. (kcal mol-1) [MP4/EXT//3-21G(d)]

Due to such instability, up to the 1960, the so-called “double-bond rule”2 has been described in textbooks as “the stable double-bond containing elements from third period onward is not in existence.” However, evidence confirming that these compounds exist in cryogenic matrix or gas phase as short-lived species, has accumulated from studies arising from the latter half of the 1960s to the 1970s. Stable compounds having P=C bonds3 as well as Si=C4, Si=Si5 and P=P6 have been synthesized and isolated for the first time in 1978 and 1981 respectively. Since then, chemistry with respect to multiple- bond compounds associated with heavier main group elements has developed rapidly and approaches the leading theme in main group element chemistry. In this paper, we describe recent developments in the field, focusing on the author’s studies.

2. Double-bond compounds containing group 14 elements (silicon, germanium, tin, lead):

2.1 Heavier main group element analogues of an alkene:

2.1.1 Disilene (Si-Si double-bond compounds) : 7 C-C double-bond compounds (alkene) represented by ethylene play an important role in organic chemistry. Normally an alkene is a stable compound in spite of its having moderate reactivity. Therefore, it was natural that we would try to synthesize such double-bond compounds containing silicon belonging to the same group of 14 located under carbon. However, such trials since end of the 19th century resulted in failure. The product obtained has proved to be its oligomer or polymer instead of the double-bond compound in question. Under the circumstances, based on such experiences, the aforementioned “double- bond rule” has come into existance. It has been confirmed that the introduction of sterically demanding substituents onto carbon and silicon containing the double-bond would be effective as a means of prevent- ing polymerization. This method is either named as kinetic stabilization, in view of the fact that it stabilizes by lowering the reaction rate associated with unstable chemical species, or is named as steric protection since it protects the highly reactive double-bond by utilizing bulky substituents. By employing this tech- nique, in 1981 silene 1 (Ad=1-adamantyl) having the first stable carbon-silicon double-bond and disilene 2 (Mes=mesityl) having a silicon-silicon double-bond were reported by Brook et al.4 and West et al.5 respec- tively. Shortly after the report by West, Masamune et al. synthesized disilene 3 using a different method.8 Afterward, several synthetic methods preparing silene9 and disilene7 were developed so that currently a considerable number of stable compounds of such types are known.

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Me Si Ad (Me Si) Si C Ad hν 3 3 3 Si C O Me3Si OSiMe 3 1

Silene 1, disilene 2 and disilene 3 are stable under inert atmosphere but they show extremely high reactivity because disilene has high HOMO and lower LUMO, compared with olefin as indicated in Figure 1. This is the reason why disilene is yellow, as opposed to the colorless olefins. Disilene 2 reacts with oxygen and produces 5 by way of 4.10 Further, it undergoes the addition reaction with water, alcohol, acids, etc. and readily produces 6.11

SiMe 3 hν Mes2Si Mes2Si SiMes 2 CC Si Si -2 (Me3Si)2 SiMe 3 2 2pπ* SiXyl 3pπ* LUMO 2 hν Xyl2Si Xyl2Si SiXyl 2 SiXyl 2 ~ 6 eV ~ 3 eV 3 Xyl = 2,6-Dimethylphenyl (~200 nm) (~400 nm)

3pπ HOMO Mes Si SiMes O π O2 2 2 2p 2 Mes2Si SiMes 2 OO O 4 5 Figure 1. HOMO and LUMO of alkene and disilene H X Mes2Si SiMes 2 2 H X

6 X = OH, OR, Cl

It is possible to synthesize many silicon compounds having new structures utilizing the high reac- tivity of disilene despite the fact that it is difficult to synthesize them through other methods. For example, by reacting with oxygen, sulfur, selenium, tellurium, diazomethane, isonitrile, azide etc. as well as reacting with ketones such as acetophenone, etc., the undermentioned tricyclic compounds 7 including silicon 12 as well as the tetracyclic compounds 8 can be synthesized respectively.13

Mes2Si SiMes 2 Mes2Si SiMes 2 CH3 X OC Ph 7 8

X = O, S, Se, Te, CH2 , C NR, NR

Disilenes 2 and 3 decompose immediately on contact with air. Their stability can be increased by adding bulkier substituents to the silicon. For example, the room temperature half-lives of compounds 9 and 10 is on the order of one day due to the presence of the bulky adamantyl and triisopropylphenyl substituents. We have been able to synthesize relatively stable compound 11 with half-life of about one month at room temperature, which makes it manageable in air. This compound has the bulky 2,4,6- tris[bis(trimethylsilyl)methyl]phenyl group (Tbt). The Tbt group has four bulky trimethylsilyl groups at the ortho positions. However, there is enough space at the 1 position, since the benzyl position is substituted with hydrogen, and this allows for sufficient reactivity to undergo the functional group transformation at that position. As has been shown, the Tbt group is extremely useful for stabilizing the high period multiple bonds which usually have high reactivity.

Mes Mes Tip Tip Si Si Si Si Ad Ad Tip Tip Tip = 2,4,6-Triisopropylphenyl 9 10

Me Si SiMe Tbt Tbt 3 3 Me3Si SiMe3 Si Si Tbt Mes Mes Me3Si SiMe3 11

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Disilene 11 is interesting in that it has the extremely bulky Tbt groups so that Si-Si double-bond is effectively protected in three dimensions. On the other hand, the silicon-silicon bond is lengthened in comparison with other disilenes so that it easily dissociates to silylene.16 X-ray crystal structure analysis of disilene 11(trans form) is shown in Figure 2.16 The length of Si-Si bond is 2.228 Å which is the longest among disilenes with bulky aryl substituents. In solution, 11 dissociates to silylene gradually at room temperature and rather rapidly at 70 °C. There- fore, trans-11 isomerizes to cis-11 and cis-11 to trans- 11 respectively even at room temperature by way of the dissociation to silylene. It is known that the isomer- ization of olefins is generated not by the cleavage of the C-C bond, but by the rotation of the bond. Also, in case of the already known disilenes having relatively smaller sized substituents on silicon, isomerization is through the rotation of the Si-Si bond in the same way as in olefins. It is interesting to know that 11 is the first disilene which isomerizes based on the dissociation- association mechanism (Figure 3). Although silylene has been generated by means of thermolysis or photolysis at relatively high temperatures up to now, the discovery of the method for generating silylene under mild condi- tions has made it possible for many new organic silicon Figure 2. Molecular structure of compounds to be synthesized, despite the fact that it disilene trans-11. had been difficult to synthesize them using the previ- ous methods. Several examples are shown in Figure 4.16,18,19

Tbt Tbt Tbt Tbt Mes Si Si 2 Si Si Si Mes Mes Mes Mes Tbt

cis-11 12 trans-11

Figure 3. cis-trans Isomerization based on the dissociation-association mechanism of disilene 11.

Tbt Me Si Tbt Mes X Si Me H Mes Mes C Me3Si Si SiMe 3 N t-BuC X Me3Si Me SiMe 3 X = N, P MesN C

Tbt Me3Si SiMe 3 Tbt 2 Si Mes*N C Si C N Mes* Mes Mes 12 CS2 Mes* = 2,4,6-tri-t-butylphenyl

S Tbt Tbt Tbt Tbt Tbt Mes Si Si Si Si Si Mes Mes Mes S Mes

Si Mes Tbt

Figure 4. Reactions of silylene 12.16,18,19

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2.1.2 The double-bond compounds of germanium, tin, and lead (digermene, distannene and diplumbene): 20 The double-bond compounds (named as digermene, distannene and diplumbene respectively) consisting of germanium, tin and lead belonging to the same group as silicon are still more unstable since the π bond energy with respect to Ge=Ge, Sn=Sn and Pb=Pb is lower in comparison to the π bond energy involved in Si=Si. On the other hand, germylene, stannylene and plumbylene of bivalent chemical species generated through dissociation of the double-bond in question are more stable. Thus, it is important to have moderate sized substituents for stable double-bond compounds. Although digermene 1321,22 and distannene 1421,22 were previously synthesized by Lappert et al. in the 1970s prior to the synthesis of disilene 2., it was impossible to study the properties of Ge=Ge and Sn=Sn since they existed in the form of germylene 15 and stannylene 16 respectively in solution despite the fact that they existed in solid phase as double-bond compounds. After the synthesis of disilenes 2 and 3, a study to synthesize digermene and distannene without causing dissociation was carried out. As a result, the compounds 1723 and 1824 were synthesized.

Dis Dis Dis MM 2 M Dis Dis Dis Dis = (Me3Si)2CH M = Ge 13 M = Ge 15 M = Sn 14 M = Sn 16

Me Me Dip Li naphthalenide Dip Dip Dip = Me Me 2 GeCl2 Ge Ge Mes Mes Mes 17

Ar Ar Me 2 SnCl 2 + 4 ArMgBr Sn Sn Ar = Me Ar Ar Me 18

Although digermene 17 does not disso- ciate to germylene, digermene 19 having larger substituents easily dissociates to germylene 20 Tbt Tbt Tbt Ge Ge 2 Ge and there is an equilibrium between both enti- Mes Mes Mes ties.25 19 In 1999, diplumbene 21 with a double- 20 bond between lead atoms occupying the low- est place in the periodic table was also synthe- sized.26 Therefore, stable double-bond com- Tip Tip Pb Pb pounds between the same elements belonging 2 PbCl2 + 4 TipMgBr Tip Tip to group 14 have been completed in the period 21 of 18 years after the synthesis of disilene 2 by West et al.

The compounds of R2M=MR2 (M=Si, Ge, Sn, Pb) such as 2, 17-19, 21 have interesting structural characteristics which are different from olefins. These compounds have a so-called “trans-bent-type struc- ture”.7,20 As shown in Figure 5, two substituents on one M and two substituents on the other M are bent in trans form with θ, the bent angle from the plane growing larger as the atomic number increases. Although details are not described in the paper, it has been revealed that the bent angle is determined by the difference of energy between singlet and triplet states of R2M: and it is more apt to take such a bent structure in proportion to the extent of the stability of the singlet state.

R R MM Rθ R

Figure 5. The trans-bent-type structure of R2M=MR2 (M=Si, Ge, Sn, Pb).

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2.2 Aromatic compounds containing silicon27

With alkenes, the primary organic compounds having unsaturated bonds are aromatic compounds including benzene, naphthalene etc. Therefore, the question of whether compounds where carbon in benzene and naphthalene is substituted by silicon exhibits aromatic properties is of great interest. Over the period of the 1970s to the 1980s a large number of studies have been carried out. It has been identified that in cryogenic matrices (argon matrix of 10 K, for example) or in the gas phase, silabenzene 22 (R=H, Me) having simple substituents such as hydrogen, methyl group etc. on silicon exists even in a short life and the UV, IR spectra etc. have been determined.28 In the meantime, 23 reported by Märkl et al. in 1988 has been a sole compound with moderate stability, despite the fact that many trials have been made to isolate silabenzenes as a stable compound29. Although 23 is sterically protected by a t-butyl group on silicon and two trimethylsilyl groups at the ortho-position, it is stable only in solution under -100 °C. Furthermore, endocyclic silicon secures stability by the coordination of THF among solvents as will be described later.

Si Me3Si Si SiMe 3 R R = H, Me 22 23

We have succeeded in isolating silabenzene 2430 and silanaphthalene 2531 as stable crystals at room temperature respectively by applying the outstanding protection ability of the Tbt group to the syn- thesis of aromatic compounds containing silicon. The synthetic precursors of 24 and 25 are halosilanes 26 and 27 respectively. The products are obtained by dehydrohalogenation of the precursors using t-butyllithium.

t-BuLi

Si cyclo-C6H12 Si Tbt Cl Tbt 26 24

Tbt t-BuLi Tbt Si Si Br n-C6H14

27 25

Both 24 and 25 are colorless crystals which are so extremely stable under inert atmosphere that they do not change at all either in crystalline state or in solution.29 According to 29Si NMR, chemical shifts of endocyclic silicon are 87.3 and 92.5 respectively which exist in the low magnetic field region character- istic of sp2 silicon. This is totally different from the chemical shift of 26.8 for compound 23 by Märkl et al. Under such circumstances, it is considered that 23 clearly is coordinated by THF as a solvent so that it is stabilized to a great extent accordingly. The coupling constant of endocyclic silicon is shown in the Figure 6. The coupling constant between two neighboring atoms correlates with the bond order involved in the linkage. According to the Figure 6, the coupling constant of silabenzene 24 is intermediate between the two coupling constants of silanaphthalene 25, which is exactly consistent with the relationship of the bond order in benzene and naphthalene. Additionally, the coupling constant of a typical Si-C single bond is approx. 50 Hz. Therefore, the Si-C bonds of 24 and 25 clearly assume a double-bond character. As a result, delocalization of π electrons clearly exists in 24 and 25 and they assume aromatic characteristics.

92 Hz

Tbt Si

Si 76 Hz 83 Hz Tbt 24 25

1 Figure 6. JSiC value of silabenzene 24 and silanaphthalene 25.

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The X-ray crystal structure analysis of 25 is shown in Figure 7. The ringed part of silanaphthalene is situated on the plane, and endocyclic silicon and the three atoms bonded to it are situated on the same plane. Further, the endocyclic silicon with high reactivity is completely protected by the Tbt group as is clear from the space-filling model (b).

(a) ORTEP drawing (b) Space filling model

Figure 7. Molecular structure of silanaphthalene.

The electronic spectra of 24 and 25 were fundamentally similar to each other despite the fact that they shifted to longer wavelengths than the corresponding benzene and naphthalene. This also supports the case that 24 and 25 have aromatic character. Meanwhile, theoretical quantum calculations of the aromatic character have become more reliable. Schleyer et al. propose that NICS (Nucleus-Independent Chemical Shift) is a good index with respect to aromatic character.32 As a result of NICS computation carried out concerning silabenzene as well as 1-sila-, 2-sila- and 9-silanaphthalene, it was determined that their aromatic characters were nearly the same despite the fact that they were slightly lower than benzene and naphthalene, and further, there were almost no differences between the three isomers of silanaphthalene with respect to aromatic character.31 The results of the computation are consistent with the experimental results obtained from NMR, UV, X-ray crystal structure analysis etc. The reactivity of 24 and 25 is very high despite the fact that they have extremely bulky substituents on silicon and their presumed aromatic character. Several examples of their reactions are shown in Figure 8. We conclude that this is based on the high reactivity associated with the Si=C double-bond exceeding the stability from the aromatic charac- ter involved in silabenzene and silanaphthalene.

D

Ph Ph + Si Si D MeOD O Tbt OMe Tbt OMe Ph2CO Si Si

Tbt Tbt MesCNO H 24 Si Mes Tbt O N

X Tbt Tbt Si Si D2O Y X = D, Y = OD or MeOH X = H, Y = OMe 25

Ph2CO MesCNO

Ph Ph Mes N O O Si Si Si Tbt Tbt

Figure 8. Reactions related to silabenzene 24 and silanaphthalene 25.

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3. Double-bond compounds containing group 15 elements (phosphorus, arsenic, antimony and bismuth)33

Azo compounds having the N-N double-bond are also well-known compounds similar to alkene. Similarly, diphosphene 28, a compound having a stable P-P double-bond, was synthesized for the first time by Yoshifuji et al. in the same year of 1981 when silene 1 and disilene 2 were also synthesized.6

Mg Mes* Tsi 2 Mes*PCl 2 PP As As Mes* Tsi 28 29

Tsi = (Me3Si)3C

Immediately afterward, diarsene 29, a stable compound having an As-As double-bond, was also synthesized using a similar method.34 The compounds, distibene and dibismuthene, having double-bonds between Sb-Sb and Bi-Bi respectively have never been synthesized despite many trials since these double- bonds are increasingly unstable. It is expected that the Tbt group will provide steric protection even for the double-bond compounds between elements in group 15. After studying various synthetic methods, we have synthesized and isolated the stable distibene 3235 and dibismuthene 3336 for the first time as green and purple crystals respectively. We developed a new synthetic method that removes selenium from the six-membered compounds 30 and 31 by using a trivalent phosphorous reagent.

Tbt M Tbt Se Se (Me2N)3P MM M M Tbt Tbt Se Tbt 30 : M = Sb 32 : M = Sb 31 : M = Bi 33 : M = Bi

Bismuth is a 6th period element with the largest atomic number among the elements having stable isotopes. With respect to the the synthesis of dibismuthene 33, it is of great interest not only from the viewpoint that it is possible for even 6th period elements to produce the double-bond (as previously de- scribed, diplumbene 21 was also synthesized as a double-bond compound between other 6th period elements after the synthesis of 33), but also from the viewpoint that it was the synthesis of the double- bond compound with the element having the heaviest atomic weight. The structures associated with both 32 and 33 were determined through X-ray crystal structure analysis. The molecular structure of 33 is shown in Figure 9,36 from which we can understand that the bulky Tbt group effectively protects the Bi-Bi double-bond which has high reactivity.

Figure 9. Molecular structure of dibismuthene 33.

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32 and 33 are relatively stable compounds in the crystalline state so we may handle them in air for short periods. However, they gradually react with oxygen in air to produce the four-membered ring com- pounds, 34 and 35. It is of great interest that the reaction proceeds by maintaining crystal phase and produces single crystals of 34 and 35. 35,36 By tracing the reaction with 32 using rapid X-ray diffraction equipment, it is found that the reaction suddenly starts after approximately a 20 hour induction period. It is assumed that oxygen enters into 32 from the surface of Tbt O the crystals and the reaction between oxygen and 32 O2 proceeds at a stretch like falling dominos after oxygen MM Tbt M M Tbt O reaches a critical concentration in the crystal. It is ex- Tbt 32 : M = Sb 34 : M = Sb tremely interesting that there are no examples of such 33 : M = Bi 35 : M = Bi reagents from outside reacting while maintaining a single crystal phase.

4. Double-bond compounds containing group 16 elements (sulfur, selenium and tellurium)

It is no exaggeration to say that the most important double-bonded compounds produced by sec- ond period elements in organic chemistry, particularly in organic synthetic chemistry, are carbonyl com- pounds as represented by aldehydes, ketones etc. It is extremely interesting to study the effect of replac- ing oxygen in the carbonyl group with the high periodic elements in question.

4.1 Telluroketone

Although thioketone (R2C=S) where sulfur replaces oxygen has been long known, selenoketone 37 (R2C=Se) was first synthesized in the middle of the 1970s by Barton et al. Barton, et al. were unable to synthesize telluroketone (R2C=Te). We have developed a reaction with hydrazone and disulfur dichloride38 or diselenium dichloride39 as a new synthetic method for thioketone and selenoketone.

S2Cl2 / NEt 3 R C S R R C N RNH2 1) EtMgBr R C Se 2) Se Cl 2 2 R

We obtained the heterocyclic telluradiazoline 36 containing new tellurium by applying the said reaction to tellurium dichloride or tellurium tetrachloride,40a from which we were able to synthesize the first stable telluroketone 37 through this thermolysis.40b

TeCl or TeCl N N CN 2 4 C C / NEt3 NH2 Te 36

CTe

37

4.2 The heavier element analogues of ketones (heavy ketones) If the ketone carbon is replaced by higher periodic elements from group 14, such as silicon, germanium, tin, or lead, the resulting compound is a heavy element analogue of a ketone which we refer to as a heavy ketone. Furthermore, if the oxygen is replaced by other elements of group 16, such as sulfur, selenium, or tellurium, the resulting compound is also referred to as a heavy ketone. As indicated in Table 2, the energies of the σ and π bonds of a carbon-oxygen double bond are approximately equal. On the other hand, in all of the heavy ketones, the σ bond is much stronger than the π bond. Thus, while a ketone readily undergoes addition and elimination reactions, heavy ketones favor addition reaction where a π bond is replaced by two more energetically stable σ bonds. For these energetic reasons, it is difficult to synthesize heavy ketone compounds. We have been able to synthesize heavy ketone compounds where bulky substituents reduce the reactivity of the π bond.

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X

H2M=X O S Se Te

H2C=X σ 93.6 73.0 65.1 57.5 π 95.3 54.6 43.2 32.0 σ + π 188.9 127.6 108.3 89.5 H2Si=X σ 119.7 81.6 73.7 63.2 π 58.5 47.0 40.7 32.9 σ + π 178.2 128.6 114.4 96.1 H2Ge=X σ 101.5 74.1 67.8 59.1 π 45.9 41.1 36.3 30.3 σ + π 147.4 115.2 104.1 89.4 H2Sn=X σ 94.8 69.3 64.3 56.4 π 32.8 33.5 30.6 26.3 σ + π 127.6 102.8 94.9 82.7 H2Pb=X σ 80.9 60.9 57.0 50.3 π 29.0 30.0 27.8 24.4 σ + π 109.9 90.9 84.8 74.7

Table 2. σ and π bond energies of H2M=X (M=C, Si, Ge, Sn, Pb; X=O, S, Se, Te) (kcal mol-1) [B3LYP/TZ(d,p)]

Many synthetic trials have been performed to synthesize doubly bonded compounds related to the heavy ketones. Several examples are shown in compounds 38 - 40. Some are not truly double-bond compounds, since to some extent the double bond character is stabilized by the coordination of heteroatoms.

tBu Ph Me N Si X tBu Si N N Ge S Si NMe2 Me N t Bu tBu 38 X = S, Se 39 X

N N M NN

40 M = Ge, Sn X = S, Se, Te

On this occasion too, we were able to synthesize many of the stable heavy ketones by using the high steric protection ability of the Tbt group. The two synthetic methods utilized are shown in Figure 10. In general, method (1) is more common, but when the synthesis of 1,2,3,4-tetrachalcogenametalloranes as the starting material is so not easy method (2) would be useful.

R1X R1 X 3 R3P M MX -3 R3PX R2XX R2

(1) The dechalcogenation reaction of 1,2,3,4-tetrachalcogenametalloranes using phosphorus reagents.

R1 [X] R1 M M X R2 R2

(2) Chalcogenation of divalent chemical species.

Figure 10. Synthetic approaches to heavy ketones.

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It is possible to isolate silanethione 41,42 germanethione 4246,47 and germaneselone 43,47,48 as stable compounds respectively when Tbt and Tip groups coexist on the group 14 elements.

Tbt Ar = Tip Si S Tip Tbt S S 3 Ph3P 41 Si S -3 Ph3PS Ar S Tbt S Tbt Si Si Ar = Mes Mes S Mes 44 Tbt X Tbt X 3 Ph3P Ge Ge X Tip X X -3 Ph3PX Tip 42 : X = S 43 : X = Se

However, when Tip is replaced with a smaller Mes group, the isolated compound is 44, a dimer, although we are able to confirm that Tbt(Mes)Si=S is produced as an intermediate through the trapped reaction. So it is important to have the steric protection of bulky substituents in order to isolate heavy ketones.42 The method based on the combination of Tbt and Tip substituents is not sufficient to synthesize heavy ketones containing tin. This is due to the reason that the reactivity is elevated as the energy involved in the double-bond containing tin goes down while the steric protecting effect does not function efficiently as the double-bond around Sn becomes longer. However, we are also able to isolate stannanethione 4549 and stannaneselone 4650 in a stable state by means of changing Tip to the Ditp group which is a larger substituent. It is possible to confirm plumbanethione 47 in desulfurization at low temperature by using the trapping reaction but isolation has not been possible.51

Tbt X Tbt X 3 Ph3P Sn Sn X Ditp = Ditp X X -3 Ph3PX Ditp 45 : X = S Me Me Me Me 46 : X = Se Mes Tbt S Tbt Tbt S S 3 R3P MesCNO Pb Pb S Pb S -3 R3PS N Tip S Tip Tip O 47

We were unable to synthesize the corresponding tetraselenasilorane (R1R2SiSe4) so we could not synthesize silaneselone (R1R2Si=Se) by deselenation. However, we were able to synthesize silaneselone 50 through the selenation reaction by using silacyclopropane 48 as a precursor of silylene 49. 52

Tbt Tbt Se (1eq.) Tbt Si Si Si Se Dip Dip Dip 48 49 50

In reference to germanium, germacyclopropenes 51, 52 function as good precursors of germylenes 53, 5453. We are able to obtain germanethione 55 and germaneselone 56 by heating 52 in the presence of sulfur and selenium.47 This reaction is particularly effective for the synthesis of Ge-Te double-bond com- pounds and we were able to synthesize germanetellones 57, 58.54

Ph Tbt Tbt Te (1 eq.) Tbt Ge Ge Ge Te R R R Ph 53 : R = Tip 57 : R = Tip 51 : R = Tip 54 : R = Dis 58 : R = Dis 52 : R = Dis Tbt S or Se (1 eq.) Ge X Dis 55 : X = S 56 : X = Se

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When we react the isolated plumbylene 59 with one equivalent of sulfur, we obtain plumbylene 61, a divalent chemical species. We were unable to obtain plumbanethione 60.55

Tbt Tbt Tbt 1/8 S8 Pb Pb S Pb S Tbt Tbt Tbt 59 60 61

Therefore, the 2-coordinated type 61 is more stable than 3-coordinated type 60 in the case of lead. This is consistant with the results of quantum chemical computations that show HPb(SH) is more stable 41a than H2Pb=S by approx. 39 kcal/mol. Heavy ketones related to lead have different properties from the light analogues.

All of the synthesized heavy ketones are observed to be colored crystals (41: yellow;42, 55, yellow- ish orange-colored;43, 45, 46, 50, 56: red;57, 58: green). The structures of silanethione 41, germane- thione 42, germaneselone 43, 56, stannaneselone 46 and germanetellone 57, 58 were determined by X- ray crystal structure analysis. The molecular structure of silanethione 41 is shown in Figure 11.42 The structural characteristics worthy of attention are that the total bond angle around silicon is 360° with trigonal planar coordination and the Si-S bond distance is 1.948 Å, which is shorter than the ordinary Si-S single bond by approx. 9 % so that obviously it has the double-bond character. All of these data were identical structural characteristics to ketone. It has been experimentally shown that heavy ketones are structurally equivalent to ketone. Other heavy ketones determined by X-ray crystal structure analysis assume the same structural characteristics.

Figure 11. The molecular structure of silanethione 41.

The important reactivity characteristic related to the carbonyl group is reversibility in the reaction of a carbon-oxygen double-bond as shown in the reaction with water and alcohol. The reaction in question proceeds based on the mechanism of addition-elimination by way of a tetracoordinated intermediate.

R R C O + R'OH R COH R OR'

The approximate equalization of σ bond energy and π bond energy associated with C=O bond as seen in Table 2 has made the aforementioned possible. However, in case of heavy ketones, the addition reaction is remarkably exothermic and irreversible for a reason that π bond energy is lower than σ bond energy to a great extent. Actually, all of the synthesized heavy ketones promptly react with water, alcohol etc. and give rise to the tetracoordinated addition product. In addition, as opposed to the case with ketone,

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they easily make the cycloadditional reaction with unsaturated chemical species such as phenyl isothiocyanate, mesitonitrile oxide, 2,3-dimethylbutadiene etc.42-50 We are able to synthesize new hetero- cyclic compounds by using these reactions despite the fact that it is difficult to synthesize them by using one of the other methods.

Tbt XH ROH M R = H or Me Tip OR

Tbt X Ph PhNCS M CN Tbt Tip S M X Tip X Mes MesCNO Tbt M : Si, Ge, Sn M X : S, Se N Tip O

Tbt X M Tip

5. Conclusion

A large number of multiple bond compounds containing high period elements of groups 14,15 and 16 have been synthesized on the basis of kinetic stabilization by using bulky substituents. Further, several multiple bond compounds containing elements in group 13 have been also synthesized although we have not referred to them in this paper. The multiple bond compounds related to high period elements have established a new field in organic chemistry and inorganic chemistry with unique compounds having inter- esting structures and reactivity. However, a large number of compounds awaiting synthesis are still left in this field. For example, there are triple bond compounds between elements in group 14, R-M≡M-R, heavy ketones containing oxygen, R2M=O (M=Si, Ge, Sn and Pb), and aromatic compounds containing Ge, Sn and Pb etc. The results described in this paper have been obtained through the efforts of many students (whose names are listed in References) under the leadership of Dr. Nobuhiro Tokitoh, currently Professor of Kyoto University. I would like to thank them. In addition, the author would also like to acknowledge Dr. Mao Minoura (Faculty of Science, Kitasato University) for his kind cooperation during preparation of the manu- script.

References 1) M. W. Schmidt, P. N. Truong, M. S. Gordon, J. Am. Chem. Soc., 109, 5217 (1987); P. v. R. Schleyer, D. Kost, J. Am. Chem. Soc., 110, 2105 (1988). 2) K. S. Pitzer, J. Am. Chem. Soc., 70, 2140 (1948). 3) T. C. Klebach, R. Lourens, F. Bickelhaupt, J. Am. Chem. Soc., 100, 4886 (1978). 4) A. G. Brook, F. Abdesaken, B. Gutekunst, G. Gutekunst, R. K. Kallury, J. Chem. Soc., Chem. Commun., 1981, 191. 5) R. West, M. J. Fink, J. Michl, Science, 214, 1343 (1981). 6) M. Yoshifuji, I. Shima, N. Inamoto, K. Hirotsu, T. Higuchi, J. Am. Chem. Soc., 103, 4587 (1981). 7) Review: R. Okazaki, R. West, Adv. Organomet. Chem., 39, 233 (1996). 8) S. Masamune, Y. Hanzawa, S. Murakami, T. Bally, J. F. Blount, J. Am. Chem. Soc., 104, 1150 (1982). 9) Review: A. G. Brook, M. A. Brook, Adv. Organomet. Chem., 39, 71 (1996). 10) A. J. Millevolte, D. R. Powell, S. G. Johnson, R. West, Organometallics, 11, 1091 (1992); K. L. McKillop, G. R. Gillette, D. R. Powell, R. West, J. Am. Chem. Soc., 114, 5203 (1992); H. Sohn, R. P. Tan, D. R. Powell, R. West, Organometallics, 13, 1390 (1994).

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11) D. N. Roark, G. J. D. Peddle, J. Am. Chem. Soc., 94, 5837 (1972); D. J. DeYoung, M. J. Fink, J. Michl, R. West, Main Group Met. Chem., 1, 19 (1987). 12) H. Piana, U. Schubert, J. Organomet. Chem., 348, C19 (1988); G. R. Gillette, R. West, J. Organomet. Chem., 394, 45 (1990); H. B. Yokelson, A. J. Millevolte, G. R. Gillette, R. West, J. Am. Chem. Soc., 109, 6865 (1987); R. West, D. J. DeYoung, K. J. Haller, J. Am. Chem. Soc., 107, 4942 (1985); R. P. Tan, G. R. Gillette, D. R. Powell, R. West, Organometallics, 10, 546 (1991); H. B. Yokelson, A. J. Millevolte, K. J. Haller, R. West, J. Chem. Soc., Chem. Commun., 1987, 1605. 13) M. J. Fink, D. J. DeYoung, R. West, J, Michl, J. Am. Chem. Soc., 105, 1070 (1983); P. Boudjouk, B.-H. Han, K. R. Anderson, J. Am. Chem. Soc., 104, 4992 (1982); P. Boudjouk, Nachr. Chem., Tech. Lab., 31, 798 (1983); A. D. Fanta, D. J. DeYoung, J. Belzner, R. West, Organometallics, 10, 3466 (1991). 14) B. D. Shepherd, D. R. Powell, R. West, Organometallics, 8, 2664 (1989). 15) R. S. Archibald, Y. van den Winkel, D. R. Powell, R. West, J. Organomet. Chem., 446, 67 (1993); H. Watanabe, K. Takeuchi, N. Fukawa, M. Kato, M. Goto, Y. Nagai, Chem. Lett., 1987, 1341. 16) N. Tokitoh, H. Suzuki, R. Okazaki, K. Ogawa, J. Am. Chem. Soc., 115, 10428 (1993); H. Suzuki, N. Tokitoh, R. Okazaki, J. Harada, K. Ogawa, S. Tomoda, M. Goto, Organometallics, 14, 1016 (1995); H. Suzuki, N. Tokitoh, R. Okazaki, Bull. Chem. Soc. Jpn., 68, 2471 (1995). 17) a) R. Okazaki, M. Unno, N. Inamoto, Chem. Lett., 1987, 2293. b) R. Okazaki, N. Tokitoh, T. Matsumoto, in “Synthetic Methods of Organometallic and Inorganic Chemistry,” ed by W. A. Herrmann, Thieme, New York (1996) Vol. 2, p. 260. 18) H. Suzuki, N. Tokitoh, R. Okazaki, J. Am. Chem. Soc., 116, 11572 (1994). 19) N. Tokitoh, H. Suzuki, R. Okazaki, J. Chem. Soc., Chem. Commun., 1996, 125; N. Takeda, H. Suzuki, N. Tokitoh, R. Okazaki, J. Am. Chem. Soc., 119, 1456 (1997). 20) Review: K. Baines, W. G. Stibbs, Adv. Oranomet. Chem., 39, 275 (1996). 21) P. J. Davidson, D. H. Harris, M. F. Lappert, J. Chem. Soc., Dalton Trans., 1976, 2268. 22) D. E. Goldberg, P. B. Hitchcock, M. F. Lappert, J. Chem. Soc., Dalton Trans., 1986, 2387. 23) S. A. Batcheller, T. Tsumuraya, O. Tempkin, W. M. Davis, S. Masamune, J. Am. Chem. Soc., 112, 9394 (1990). 24) M. Weidenbruch, H. Killian, K. Peters, H. G. v. Schnering, Chem. Ber., 128, 983 (1995). 25) K. Kishikawa, N. Tokitoh, R. Okazaki, Chem. Lett., 1998, 239. 26) M. Stürmann, W. Saak, H. Marsmann, M. Weidenbruch, Angew. Chem., Int. Ed., 38, 187 (1999). 27) Y. Apeloig, M. Karni, in “The Chemistry of Organic Silicon Compounds,” ed by Z. Rappoport, Y. Apeloig, Wiley, New York (1998) Vol. 2, Chapter 1. 28) T. J. Barton, D. Banasink, J. Am. Chem. Soc., 99, 5199 (1977); H. Bock, R. A, Bowling, B. Solouki, T. J. Barton, G. T. Burns, J. Am. Chem. Soc., 102, 429 (1980); T. J. Barton, G. T. Burns, J. Am. Chem. Soc., 100, 5246 (1978); G. Maier, G. Mihm, H. P. Reisenauer, Angew. Chem., Int. Ed. Engl., 19, 52 (1980). 29) G. Märkl, W. Schlosser, Angew. Chem., Int. Ed. Engl., 27, 963 (1988). 30) K. Wakita, N. Tokitoh, R. Okazaki, S. Nagase, Angew. Chem., Int. Ed., 39, 634 (2000). 31) N. Tokitoh, K. Wakita, R. Okazaki, S. Nagase, P. v. R. Schleyer, H. Jiao, J. Am. Chem. Soc., 119, 6951 (1997); K. Wakita, N. Tokitoh, R. Okazaki, S. Nagase, P. v. R. Schleyer, H. Jiao, J. Am. Chem. Soc., 122, 5648 (2000). 32) P. v. R. Schleyer, C. Maerker, A. Dransfeld, H. Jiao, N. J. R. v. E. Hommes, J. Am. Chem. Soc., 118, 6317 (1996). 33) M. Yoshifuji, in “Multiple Bonds and Low Coordination in Phosphorus Chemistry,” ed by M. Regitz, O. J. Scherer, Thieme, New York (1990), Chapter 9. 34) A. Cowley, J. G. Lasck, N. C. Norman, M. Pakulski, J. Am. Chem. Soc., 105, 5506 (1983). 35) N. Tokitoh, Y. Arai, T. Sasamori, R. Okazaki, S. Nagase, H. Uekusa, Y. Ohashi, J. Am. Chem. Soc., 120, 433 (1998). 36) N. Tokitoh, Y. Arai, R. Okazaki, S. Nagase, Science, 277, 78 (1997). 37) T. G. Back, D. H. R. Barton, M. R. Britten-Kelly, F. S. Guziec, Jr., J. Chem. Soc., Perkin Trans. 1, 1976, 2079. 38) R. Okazaki, K. Inoue, N. Inamoto, Bull. Chem. Soc. Jpn., 54, 3541 (1981). 39) A. Ishii, R. Okazaki, N. Inamoto, Bull. Chem. Soc. Jpn., 61, 861 (1988). 40) a) M. Minoura, T. Kawashima, N. Tokitoh, R. Okazaki, Tetrahedron, 53, 8137 (1997). b) M. Minoura, T. Kawashima, R. Okazaki, J. Am. Chem. Soc., 115, 7019 (1993); M. Minoura, T. Kawashima, R. Okazaki, Tetrahedron Lett., 38, 2501 (1997). 41) Reviews: a) N. Kano, N. Tokitoh, R. Okazaki, Yuki Gosei Kagaku Kyokai Shi (J. Synth. Org. Chem. Japan), 56, 919 (1998). b) N. Tokitoh, T. Matsumoto, R. Okazaki, Bull. Chem. Soc. Jpn., 72, 1665 (1999). c) N. Tokitoh, R. Okazaki, in “ The Chemistry of Organic Silicon Compounds,” ed by Z. Rappoport, Y. Apeloig, Wiley, New York (1998) Vol. 2, Chapter 17. 42) H. Suzuki, N. Tokitoh, R. Okazaki, S. Ngase, M. Goto, J. Am. Chem. Soc., 120, 11096 (1998). 43) R. Arya, J. Boyer, F. Carré, R. Corriu, G. Lanneau, J. Lapasset, M. Perrot, C. Priou, Angew. Chem., Int. Ed, Engl., 28, 1016 (1989). 44) a) M. Veith, S. Becker, V. Huch, Angew. Chem., Int. Ed, Engl., 28, 1237 (1989). b) M. Veith, A. Detemple, V. Huch, Chem. Ber., 124, 1135 (1991). c) M. Veith, A. Detemple, Phosphorus, Sulfur, Silicon, 65, 17 (1992).

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45) a) M. C. Kuchta, G. Parkin, J. Chem. Soc., Chem. Commun., 1994, 1351. b) M. C. Kuchta, G. Parkin, J. Am. Chem. Soc., 116, 8372 (1994). c) W.-P. Leung, W.-H. Kwok, L. T. C. Law, Z.-Y. Zhou, T. C. W. Mak, J. Chem. Soc., Chem. Commun., 1996, 505. 46) N. Tokitoh, T. Matsumoto, K. Manmaru, R. Okazaki, J. Am. Chem. Soc., 115, 8855 (1993). 47) T. Matsumoto, N. Tokitoh, R. Okazaki, J. Am. Chem. Soc., 121, 8811 (1999). 48) T. Matsumoto, N. Tokitoh, R. Okazaki, Angew. Chem., Int. Ed. Engl., 33, 2316 (1994). 49) M. Saito, Ph.D. Thesis, The University of Tokyo, 1996. 50) M. Saito, N. Tokitoh, R. Okazaki, J. Am. Chem. Soc., 119, 11124 (1997). 51) N. Kano, N. Tokitoh, R. Okazaki, Chem. Lett., 1997, 277; N. Kano, N. Tokitoh, R. Okazaki, Organometallics, 16, 4237 (1997). 52) T. Sadahiro, N. Tokitoh, R. Okazaki, unpublished results. 53) N. Tokitoh, K. Kishikawa, T. Matsumoto, R. Okazaki, Chem. Lett., 1995, 827. 54) N. Tokitoh, T. Matsumoto, R. Okazaki, J. Am. Chem. Soc., 119, 2337 (1997). 55) N. Kano, Ph.D. Thesis, The University of Tokyo, 1998.

Introduction of the author :

Renji Okazaki

Professor, Faculty of Science, Japan Women’s University

Born in Tokyo in 1937 and graduated from Department of Chemistry, Faculty of Science, The University of Tokyo in 1961. Completed the Doctor’s Course at the Graduate School, The University of Tokyo in 1966. The present post was gained since 1998 by way of holding research associate, associate professor and professor in succession at Faculty of Science, The University of Tokyo. Received The Divisional Award (Organic Chemistry) of The Chemical Society of Japan in 1988, Alexander von Humboldt Award in 1998, The Chemical Society of Japan Award in 1999. The present vice-president of The Chemi- cal Society of Japan and Editor-in-Chief of Bulletin of The Chemical Society of Japan. Specialized in organoheteroatom chemistry, organometallic chemistry, particularly a study for sta- bilizing the unstable chemical species utilizing new steric protection groups.

15 January, 2000 number 105

CHEMICALS NOTE

The Suzuki Reaction in Biaryl Synthesis

Kayo Ishikawa, Reagent Development Department, Tokyo Kasei Kogyo Co., Ltd.

Biaryls and their homologues are an important class of organic compounds because several types of interesting compounds such as natural products, polymers, advanced materials, liquid crystals, supermolecules, and pharmaceuticals, include the biaryl unit. Therefore, a great number of studies in regard to the biaryl synthesis have been carried out. Particularly, development in cross-coupling reactions using organometallic catalysts has been rapid. In 1981, Suzuki and Miyaura et al. reported that the cross-coupling reaction of phenylboronic acid with aryl bromide in the presence of palladium catalysts and base provides corresponding biaryls in good yields1). The Suzuki reaction is tolerant of a wide variety of functional groups, so that various substituted aromatic rings can be used. By-products from homocoupling are limited because of the selective reaction involved. Arylboronic acids are stable and they are easily treated. Furthermore, they have lower toxicity in comparison with other organometallic reagents. Therefore, the Suzuki reaction has been used for biaryl synthesis in various fields. It is an important reaction in organic synthesis.

Pd(PPh 3)4 + B(OH)2 Br aq. Na 2CO3 benzene, reflux Z Z

1. Preparation of arylboronic acids Arylboronic acids are prepared from aryllithiums or Grignard reagents and trialkyl borates. They are normally stable in air and heat, and can be recrystallized from water or alcohol. Arylboronic acids are easily dehydrated to produce a trimer, a boroxine (ArBO3), and exist as mixtures of arylboronic acid and boroxine, which can be used in the Suzuki reaction as they are.

i) B(OR)3 ArM ArB(OH)2 ii) H2 O M = Li or MgX

Various arylboronic acids are prepared relatively easily by functionalization reactions of the parent arylboronic acid since the boronic acid group is inert to many chemical reactions. The convenient method for the preparation of arylboronate from aryl halides or triflates using bis(pinacolate)diboron which is thermally stable and easily handled in air was recently reported2). It is possible to prepared the substituted arylboronic acid derivatives directly due to be tolerant of involved functional groups.

O O B B O O O X , PdCl 2(dppf) B KOAc / DMSO or dioxane O Z Z X = I, Br, OTf

16 January, 2000 number 105

2. Mechanism The general catalytic cycle for the cross-coupling of organometallics with organic halides catalyzed by transition metals, which involves (a) oxidative addition, (b) transmetallation, (c) reductive elimination sequences, is widely accepted (Figure 1). Although a similar catalytic cycle has also been suggested for the Suzuki reaction3), it differs in that two equivalent bases are required (Figure 2). The coupling reaction of organic boron compounds proceeds only in the presence of bases. This is due to the fact that the organic group on boron is not nucleophilic enough for the transfer from the boron to the palladium in the transmetallation step because of the strong covalent character of the B-C bond in boron compounds. Therefore, it is necessary to increase the carbanion character of organic groups by the formation of an organoborate with a tetravalent boron atom, which utilizes base. Further, it is known that bases substitute for Pd-X to form Pd-OH (or Pd-OR) which has higher activity. Thus, the transmetallation reaction in the Suzuki reaction is favored by the formation of both four-coordinated boron compounds and Pd-OH (or Pd-OR).

Ar Ar' ArX M(0) RX Pd(0)

RR'

reductive oxidative Ar Pd Ar' Ar Pd X elimination addition RMX

NaOH B(OH)4 trans metalization ArPd OH RMR' R'M' OH NaX Ar'B(OH)2 NaOH M = Ni, Pd Ar' B OH X = Br, I M' = Mg, Sn, Zn, Al .... OH

Figure 1 Figure 2

3. Biaryl synthesis The table lists some representative biaryls which are synthesized by the Suzuki reaction. The tabulated examples show that the biaryls are synthesized in high yields, even if they have functional groups such as hydroxy, carboxy and formyl groups etc.

B(OH)2 + X

R1 R2 R1 R2

R1 R2 X Catalyst Base Yield(%)

H 2-Me Br Pd(PPh3)4 Na2CO3 94 H 4-OH I Pd(OAc)2 Na2CO3 80 H 4-COOH I Pd(OAc)2 Na2CO3 95 4-F 4-CHO Br Pd/C + PPh3 Na2CO3 84 2-CHO 2-NO2 Br Pd(PPh3)4 Et3N82 3-NO2 H Br Pd(PPh3)4 Na2CO3 95

17 January, 2000 number 105

Aryl halide and aryl triflate function as electrophiles whose reactivity order is Ar-I > Ar-Br > Ar-OTf >> Ar-Cl. Aryl chlorides are usually not reactive enough, with the exception of those having heteroaromatic rings and electron-withdrawing groups. This is because the oxidative addition of aryl chlorides to palla- dium complexes is too slow to develop the catalytic cycle. A recent paper showed that the use of nickel catalysts for the cross-coupling reaction with aryl chlorides obtained favorable results4).

Although the most often used catalyst in the Suzuki reaction is Pd(PPh3)4, various palladium cata- lysts are also employed, such as Pd(dppb)Cl2, PdCl2(PPh3)2, Pd(OAc)2 and PdCl2 etc. PPh2(m-C6H4SO3Na) is used as phosphine ligand when the reaction is carried out in aqueous solvent. For example, the cross-

coupling reaction using the water-soluble palladium complex Pd[PPh2(m-C6H4SO3Na)]3 between sodium 4-bromobenzenesulfonate and 4-methylbenzeneboronic acid obtained the corresponding biaryl in good 5) yield , compared to using Pd(PPh3)4 in a two-phase organic solvent.

Pd[PPh 2(m-C6H4SO3Na)] 3 Me B(OH)2 + Br SO3Na Me SO3Na H2O / EtOH Y.78%

Bases are always required in the Suzuki reaction as opposed to the coupling reaction using organotin

or organozinc reagents. The best results are achieved with the use of a relatively weak base and Na2CO3 is a most frequently used. However, the strong bases such as Ba(OH)2 and K3PO4 are efficient in reac- tions involving steric hindrances. It is also possible to perform a coupling reaction with heterocyclic compounds in the same way. For example, 2,3'-bithiophene is obtained from 2-thiopheneboronic acid and 3-bromothiophene6). In addition, 2,2'-functionalized asymmetric biaryls provide a convenient route for the construction of tricyclic aromatics. For example, 2-formylphenylboronic acid is coupled with 2-amidoiodothiophene to give tricyclic heteroaromatic rings in one-pot without isolating the first biaryl generated7).

I B(OH)2 S + i) Pd(PPh3)4, NaHCO3 ii) HCl N CHO tBuCONH S Y.75%

4. Application of Suzuki reaction The Suzuki reaction is widely utilized in the synthesis of biologically active substances, pharma- ceuticals, functional materials etc., and a large number of applications are reported. For example, anti- HIV alkaloid, Michellamine, with the expectation of being a drug for AIDS was synthesized using a double Suzuki-type cross-coupling reaction8). In addition, with the aim at appearance of new functions, a fully aromatic hyperbranched polyphenylene9), which was generated by homocoupling of 3,5- dibromophenylboronic acid, and dendrimers10), having a high number of aromatic chain ends, were syn- thesized under the Suzuki reaction.

The Suzuki reaction is one of the direct methodologies for the formation of carbon-carbon bonds, so it is a useful method for constructing the carbon skeletal structure of target molecules.

18 January, 2000 number 105

OTf Me B(OH)2 Pd(PPh ) , DME/H O OAc OMe BnO Me 3 4 2 Ba(OH) , 80 , 8h, 74% + 2 N hydrogenolysis Bn OMe OAc hydrolysis Me OBn Me atropisomer separation OTf 28 29

Me OH Me OH Bn HN N

Me OH Me OH P M Me Me OH OMe OH OMe

OMe OH OMe OH Me Me P P HO Me HO Me

NH NH

OH Me OH Me Michellamine A Michellamine B

Although in this article only biaryl syntheses using the coupling reaction of arylboronic acids with aryl halides or aryl triflates have been described, it is also possible for the Suzuki reaction to be used for coupling reactions between various organic boron compounds and a variety of organic halides. Further detailed information can be found in the references cited.

References 1) N. Miyaura, T. Yanagi, A. Suzuki, Synth. Commun., 11, 513 (1981). 2) T. Ishiyama, M. Murata, N. Miyaura, J. Org. Chem., 60, 7508 (1995). T. Ishiyama, Y. Itoh, T. Kitano, N. Miyaura, Tetrahedron Lett., 38, 3447 (1997). 3) N. Miyaura, K. Yamada, H. Suginome, A. Suzuki, J. Am. Chem. Soc., 107, 972 (1985). 4) S. Saito, M. Sakai, N. Miyaura, Tetrahedron Lett., 37, 2993 (1996). 5) A. L. Casalnuovo, J. C. Calabrese, J. Am. Chem. Soc., 112, 4324 (1990). 6) S. Gronwitz. V. Bobosik, K. Lawitz, Chem. Scripta, 23, 120 (1984). 7) Y. Yang, A.-B. Hörnfeldt, S. Gronowitz, J. Heterocycl. Chem., 26, 865 (1989). 8) G. Bringmann, R. Götz, P. A. Keller, R. Walter, M. R. Boyd, F. Lang, A. Garcia, J. J. Walsh, I. Tellitu, K. V. Bhaskar. T. R. Kelly, J. Org. Chem., 63, 1090 (1998). 9) Y. H. Kim, O. W. Webster, J. Am. Chem. Soc., 112, 4592 (1990). 10) V. Percec, P. Chu, G. Ungar, J. Zhou, J. Am. Chem. Soc., 117, 11441 (1995).

Review N. Miyaura, A. Suzuki, Yuki Gosei Kagaku Kyokai Shi (J. Synth. Org. Chem. Jpn), 46, 848 (1988) . A. R. Martin, Y. Yang, Acta Chem. Scand., 47, 221 (1993). N. Miyaura, A. Suzuki, Chem. Rev., 95, 2457 (1995). N. Miyaura, Fain Kemikaru (Fine Chemical), 26 (6), 5 (1997). idem, ibid., 26 (7), 13 (1997). S. P. Stanforth, Tetrahedron, 54, 263 (1998). A. Suzuki, J. Organomet. Chem., 576, 147 (1999).

Arylboronic acids B0857 Phenylboronic Acid 25g JPYen 9,900 5g JPYen 3,400 P1358 1,4-Phenylenediboronic Acid 1g JPYen 13,800 M1313 2-Methylphenylboronic Acid 5g JPYen 12,500 M1314 3-Methylphenylboronic Acid 5g JPYen29,100 1g JPYen 9,800 M1126 4-Methylphenylboronic Acid 5g JPYen 9,800 V0075 4-Vinylphenylboronic Acid 5g JPYen 12,000

19 January, 2000 number 105

M1261 2-Methoxyphenylboronic Acid 5g JPYen 16,000 1g JPYen 5,750 M1322 3-Methoxyphenylboronic Acid 1g JPYen 4,300 M1252 4-Methoxyphenylboronic Acid 25g JPYen 34,000 5g JPYen 9,800 C1613 3-Chlorophenylboronic Acid 5g JPYen 12,400 C1473 4-Chlorophenylboronic Acid 5g JPYen 9,900 D2494 2,4-Dichlorophenylboronic Acid 1g JPYen 8,400 B1858 4-Bromophenylboronic Acid 5g JPYen 11,100 1g JPYen 3,700 F0407 2-Fluorophenylboronic Acid 1g JPYen 5,650 F0404 3-Fluorophenylboronic Acid 1g JPYen 8,900 F0361 4-Fluorophenylboronic Acid 25g JPYen 21,500 5g JPYen 7,050 T1800 2-(Trifluoromethyl)phenylboronic Acid 5g JPYen 38,000 1g JPYen 11,100 T1793 3-(Trifluoromethyl)phenylboronic Acid 1g JPYen 8,400 T1788 4-(Trifluoromethyl)phenylboronic Acid 1g JPYen 12,900 B1886 3,5-Bis(trifluoromethyl)phenylboronic Acid 5g JPYen 24,500 1g JPYen 7,950 T1773 4-(Trifluoromethoxy)phenylboronic Acid 5g JPYen 24,600 B1873 Benzaldehyde-2-boronic Acid 5g JPYen 14,000 1g JPYen 4,600 C1353 4-Carboxyphenylboronic Acid 5g JPYen 35,800 1g JPYen 10,500 A1281 3-Aminophenylboronic Acid 5g JPYen 19,400 1g JPYen 6,550 N0563 3-Nitrophenylboronic Acid 5g JPYen 10,200 M1127 4-Methyl-3-nitrophenylboronic Acid 5g JPYen 12,900 N0630 1-Naphthaleneboronic Acid 5g JPYen 16,700 1g JPYen 5,950 N0649 2-Naphthaleneboronic Acid 1g JPYen 10,000 P1093 9-Phenanthreneboronic Acid 100mg JPYen 6,450 F0394 2-Furylboronic Acid 5g JPYen 19,400 1g JPYen 7,450 T1772 2-Thiopheneboronic Acid 1g JPYen 11,000 D2661 Diethyl(3-pyridyl)borane 1g JPYen 17,100

Reagents for Boronic acids B1964 Bis(pinacolato)diboron 1g JPYen25,400 B0522 Trimethyl Borate 500ml JPYen 6,150 25ml JPYen 1,600 B0520 Triethyl Borate 500ml JPYen 16,500 25ml JPYen 2,650 B0518 Tri-n-butyl Borate 500ml JPYen 9,300 25ml JPYen 1,800 B0521 Triisopropyl Borate 500ml JPYen 17,600 25ml JPYen 2,100

Catalysts T1350 Tetrakis(triphenylphosphine) Palladium(0) 5g JPYen13,000 1g JPYen 5,000 A1424 Palladium(II) Acetate 1g JPYen 5,450 B1374 Bis(dibenzylideneacetone) Palladium(0) 5g JPYen50,500 1g JPYen14,700 B1667 Bis(triphenylphosphine)palladium(II) Dichloride 5g JPYen13,800 1g JPYen 4,200 B2026 Bis(tri-o-tolylphosphine)palladium(II) Dichloride 1g JPYen 5,750 B2055 Bis(tricyclohexylphosphine)palladium(II) Dichloride 1g JPYen 8,400 B2042 Bis(triphenylphosphine)palladium(II) Diacetate 1g JPYen 5,850 B2016 [1,2-Bis(diphenylphosphino)ethane]palladium(II) Dichloride 5g JPYen26,700 1g JPYen 8,400 B2031 [1,4-Bis(diphenylphosphino)butane]palladium(II) Dichloride 1g JPYen16,700 B1313 1,3-Bis(diphenylphosphino)propane Nickel(II) Chloride 10g JPYen11,400 B1571 Bis(triphenylphosphine)nickel(II) Dichloride 100g JPYen17,300 10g JPYen 3,400

Phosphine ligands B2027 1,1'-Bis(diphenylphosphino)ferrocene (dppf) 5g JPYen 15,900 1g JPYen 5,950 B1137 1,2-Bis(diphenylphosphino)ethane (dppe) 10g JPYen 6,050 B1138 1,3-Bis(diphenylphosphino)propane (dppp) 25g JPYen 21,000 5g JPYen 8,050 B1246 1,4-Bis(diphenylphosphino)butane (dppb) 25g JPYen 15,500 5g JPYen 5,200 D2043 Diphenylphosphinobenzene-3-sulfonic Acid Sodium Salt 5g JPYen 24,800 1g JPYen 8,400 T1165 Tricyclohexylphosphine (ca 15% in Toluene) 500ml JPYen 50,000 25ml JPYen 5,950 T1643 Tri(2-furyl)phosphine 5g JPYen 27,400 1g JPYen 7,950 T1614 Tris(2,6-Dimethoxyphenyl)phosphine 25g JPYen 8,900 T0861 Tris(4-methoxyphenyl)phosphine 5g JPYen30,000 T0862 Tris(4-methylphenyl)phosphine 25g JPYen 21,900 5g JPYen 5,650 T1025 Tris(3-methylphenyl)phosphine 5g JPYen 6,450 T1024 Tris(2-methylphenyl)phosphine 25g JPYen 13,500 5g JPYen 4,500 T0519 Triphenylphosphine 500g JPYen 7,650 25g JPYen 1,300

20 January, 2000 number 105

ANTI-SELECTIVE ASYMMETRIC ALDOL REACTION

P1371 (1R,2S)-2-(N-Benzyl-N-mesitylenesulfonyl)amino-1-phenyl- 1-propyl Propionate 1a 1g JPYen 16,400 P1372 (1S,2R)-2-(N-Benzyl-N-mesitylenesulfonyl)amino-1-phenyl- 1-propyl Propionate 1b 1g JPYen 16,400 B2103 (1R,2S)-2-(N-Benzyl-N-mesitylenesulfonyl)amino-1-phenyl- 1-propanol 2a 1g JPYen 10,000 B2104 (1S,2R)-2-(N-Benzyl-N-mesitylenesulfonyl)amino-1-phenyl- 1-propanol 2b 1g JPYen 10,000

Ph O Ph O OH OH Me Me O i) ( c-Hex)2BOTf, Et3N O R LiAlH4 HO R ii) RCHO N N i Bn SO Mes Bn SO Mes R = Pr Y.~100% 2 Me 2 4a 1aMes = Me 3a + Ph Me yield* (ds for anti) Me R =iPr 98% (98 : 2) OH R =Ph 93% (95 : 5) N R =(E)-MeCH CH 96% (98 : 2) Bn SO2Mes * Syn isomers < 2% 2a

EtCOCl, Py.

The construction of the anti- and syn-3-hydroxy-2-methylcarbonyl structural units is important for the synthesis of polyketide natural products exemplified by macrolides. While the efficient construction of the syn unit can now be readily achieved through asymmetric aldol reactions, methods for the direct elaboration of the anti counterparts have met with limited success. Recently, A. Abiko and S. Masamune et al. have developed a highly enantioselective anti-aldol reaction using the chiral ester 1 with dicyclohexylboron triflate and triethylamine1). The ester 1 is a superb stereocontrolling reagent in terms of both simple diastereo- and diastereofacial selectivities. The anti-aldol reaction can be carried out with a wide variety of aldehydes in high reaction yield and under mild condition. The anti-aldol products 3 are con- verted to the corresponding alcohols 4 by LiAlH4 and/or carboxylic acids by LiOH without loss of the stereochemical integrity. The chiral auxiliary alcohols 2 can be recovered in nearly quantitative yield and reused. An application to a natural product synthesis has been reported2).

References 1) The anti-selective boron-mediated asymmetric aldol reaction A. Abiko, J.-F. Liu, S. Masamune, J. Am. Chem. Soc., 119, 2586 (1997). A. Abiko, Org. Synth., submitted. 2) An application to a natural product synthesis T. Yoshimitsu, J. J. Song, G.-Q. Wang, S. Masamune, J. Org. Chem., 62, 8978 (1997).

(1R,2S)-and(1S,2R)-2-(N-Benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl Acetate are scheduled to be manufactured as related products for use in the Double Aldol Reaction.

21 January, 2000 number 105

KETENE EQUIVALENT

A1477 2-Acetoxyacrylonitrile 5g JPYen 10,500

OAc 1a)

CN 1 NaOH 100 , 3h 100 , 2h Y. 62%OAc Y. 82% NC O 1b) O O Me Me Me 1 , Hydroquinone KOH, H O AcO 2 OBn High-pressure THF, HCHO O Y. 98% Y. 91% NC O OBn OBn Generally, ketenes react with conjugate dienes by [2+2] cycloaddition so that the Diels-Alder adducts are not obtained. The reagent 1 is a ketene equivalent that undergoes the Diels-Alder reac- tion with a variety of dienes. For example, 1 reacts thermally with cyclopentadiene to yield a cycloadduct which upon treatment with base produces norbornenone1a). Furthermore, 1 also reacts with substitute furanes and this reaction has been used for the synthesis of sesquiterpene which is a family of biologically active natural products1b).

References 1) Diels-Alder reactions a) P. D. Bartlett, B. E. Tate, J. Am. Chem. Soc., 78, 2473 (1956). b) D. S. Brown, L. A. Paquette, J. Org. Chem., 57, 4512 (1992). 2) Review S. Ranganathan, D. Ranganathan, A. K. Mehrotra, Synthesis, 1977, 289. 3) Other reactions a) A. Oku, T. Yokoyama, T. Harada, J. Org. Chem., 48, 5333 (1983). b) A. Padwa, D. N. Kline, K. F. Koehler, M. Matzinger, M. K. Venkatramanan, J. Org. Chem., 52, 3909 (1987). c) W. L. Dilling, R. D. Kroening, J. C. Little, J. Am. Chem. Soc., 92, 928 (1970).

SYNTHESIS OF 3-SUBSTITUTED INDOLES

B2057 3-Bromo-1-(triisopropylsilyl)indole 1g JPYen 21,800

Br R R t n i) BuLi, THF, -78 Bu4NF ii) Electrophile, THF N N N -78 H i i Si Pr3 Si Pr3 1 Electrophile is Mel, R=Me Y=90% 1) 1) HCONMe2, R=CHO Y=90% 1) CO2, R=COOH Y=90% i 2) B(O Pr)3, R=B(OH)2 Y=93% The 3-lithiated indole is generated from silylindole 1 by treatment with alkyllithium and when allowed to react at -78 ˚C with various electrophiles, regioselectively yields 3-substituted indoles in good yield . This is because the lithiated intermediate contains a bulky triisopropylsilyl group at the 1-position. The steric bulk provides protection at the 2-position of indole which prevent 3→2 migra- tion of lithium and subsequent ring fragmentation1). Reported applications of 1 are the synthesis of tryptophan2) and the total synthesis of grossularine-1 3) which is a type of alkaloid.

References 1) Synthesis of 3-substituted indoles M. Amat, S. Sathyanarayana, S. Hadida, J. Bosch, Heterocycles, 43, 1713 (1996). 2) Synthesis of β-Methyltryptophan R. S. Hoerrner, D. Askin, R. P. Volante, P. J. Reider, Tetrahedron Lett., 39, 3455 (1998). 3) Total synthesis of Grossularines-1 and -2 T. Choshi, S. Yamada, E. Sugino, T. Kuwada, S. Hibino, J. Org. Chem., 60, 5899 (1995).

22 January, 2000 number 105

USEFUL Pd(II) CATALYST FOR CROSS COUPLING REACTIONS

B2029 Benzylchlorobis(triphenylphosphine)palladium(II) 1g JPYen 26,500 100mg JPYen 4,500

1) Ph3P Cl Pd Ph O Ph3P O 1 (0.1-5mol%) 3 2 + R 3SnR 1 2 R1 Cl THF or HMPA, 65 R R 1min-hours

1 R =alkyl, aryl, vinyl, alkynyl, allyl, -OR, -NR2 R2=alkyl, aryl, vinyl, alkynyl, allyl R3=Bu, Me Palladium compound 1 catalyzes the cross coupling reaction of acid chlorides with tetraorganotin compounds to give ketones under mild conditions and in high yields 1). The reaction is tolerant of a wide variety of functional groups both on the acid chloride and the tin reagent, thus making this reaction a useful method for ketone synthesis. Palladium compound 1 is an excellent catalyst, giving higher reaction yields and shorter reaction times than other palladium catalysts.

References 1) Cross coupling reactions with acyl chlorides and Organostannane compounds D. Milstein, J. K. Stille, J. Am. Chem. Soc., 100, 3636 (1978). idem, J. Org. Chem., 44, 1613 (1979). M. W. Logue, K. Teng, J. Org. Chem., 47, 2549 (1982). J. W. Labadie, D. Tueting, J. K. Stille, J. Org. Chem., 48, 4634 (1983). K.-T. Kang, S. S. Kim, J. C. Lee, Tetrahedron Lett., 32, 4341 (1991). 2) Review: The Stille reaction V. Farina, V. Krishnamurthy, W. J. Scott, Organic Reactions, 50, 1 (1997).

USEFUL PHOSPHINE LIGAND

B2027 1,1'-Bis(diphenylphosphino)ferrocene (dppf) 5g JPYen15,900 1g JPYen 5,950

PPh2 Fe

PPh2

1 1) Br Br

Pd cat. + ++ r. t. MCl

M=Mg, PdCl2(PPh3)2, 24h 5% 6% 9% PdCl 2(dppf) , 1h 95% 0% 0% M=Zn , PdCl2(PPh3)2, 22h 3% 3% 87% PdCl 2(dppf) , 20h 100% 0% 0% The phosphine ligand 1 forms complexes with Group 9 and 10 metals which are used as a catalyst for the formation of a wide variety of C-C bonds. For example, palladium and nickel complexes cleanly and selectively catalyze cross-coupling reactions of organic electrophiles and organometallic reagents without the usual side reactions such as isomerization1). Rhodium complex with 1 catalyzes hydroformylation of allyl alcohol, which is a conve- nient route to 1,4-butanediol. This reaction gives a higher linear to branched selectivity than does the triphenylphosphine ligand2).

References 1) Cross-coupling reaction T. Hayashi, M. Konishi, Y. Kobori, M. Kumada, T. Higuchi, K. Hirotsu, J. Am. Chem. Soc., 106, 158 (1984). 2) Hydroformylation of allyl alcohol C. U. Pittman, Jr., W. D. Honnick, J. Org. Chem., 45, 2132 (1980).

23 January, 2000 number 105

CHIRAL LIGANDS

B1614 (-)-4,5-Bis[hydroxy(diphenyl)methyl]-2,2-dimethyl- 1,3-dioxolane 1a 5g JPYen 9,800 B2048 (+)-4,5-Bis[hydroxy(diphenyl)methyl]-2,2-dimethyl- 1,3-dioxolane 1b 5g JPYen 18,800 1g JPYen 7,250

Ph Ph Me O OH 1)

Me O OH Ph Ph Et OH O 1a (1 eq.) 3 Et MgBr + Ph Me Ph Me THF, -100 (R ) 99:1

2) Ti Ph H i) CpTiCl 3,Et3N O PhCHO OH 1a O Ph Ph ii) MgCl Ph Ph O O 95% e.e. Cp=cyclopentadienyl

Chiral ligand 1 is used for enantioselective addition of Grignard reagents to ke- tones which affords tertiary alcohols with high optical yields1). Furthermore, a variety of titanium complexes may be prepared from 1, and the titanium complexes are used for asymmetric allylation reactions2), asymmetric alkylation reactions3), asymmetric iodocarbocyclization reactions4), and asymmetric Diels-Alder reactions5) etc.

References 1) Asymmetric addition of primary alkyl Grignard reagents to ketones B. Weber, D. Seebach, Angew. Chem. Int. Ed. Engl., 31, 84 (1992). 2) Asymmetric allylation of aldehydes A. Hafner, R. O. Duthaler, R. Marti, G. Rihs, P. R.-Streit, F. Schwarzenbach, J. Am. Chem. Soc., 114, 2321 (1992). 3) Asymmetric alkylation of aldehydes B. Schmidt, D. Seebach, Angew. Chem. Int. Ed. Engl., 30, 99 (1991). D. Seebach, L. Behrendt, D. Felix, ibid., 30, 1008 (1991). D. Seebach, D. A. Plattner, A. K. Beck, Y. M. Wang, D. Hunziker, W. Petter, Helv. Chim. Acta, 75, 2171 (1992). 4) Asymmetric iodocarbocyclization T. Inoue, O. Kitagawa, O. Ochiai, M. Shiro, T. Taguchi, Tetrahedron Lett., 36, 9333 (1995). 5) Asymmetric Diels-Alder reaction K. Narasaka, M. Inoue, N. Okada, Chem. Lett., 1986, 1109.

Related Products B1615 (+)-4,5-Bis[hydroxy(diphenyl)methyl]-2-methyl-2-phenyl-1,3-dioxolane 1g JPYen 15,600

24 January, 2000 number 105

NON-COORDINATIVE COUNTER ANION

L0158 Lithium Tetrakis(pentafluorophenyl)borate - Ethyl Ether Complex 1g JPYen 16,300

+ 2)

i) AgSO CF 3 3 - Ph5TeCl Te (C6F5)4B ii) LiB(C6F5)4 1

2 - Tetrakis(pentafluorophenyl)borate[(C6F5)4B ] is a weak nucleophilic and an inert non- coordinative anion. Therefore it is employed as a counter anion to unstable cation chemical species, thereby generating the “free” cation that may be used for studies related to reactivity and structure1,2). Minoura, et al. have succeeded in synthesizing the first nonclassical onium compound, pentaphenyltelluronium 2, using the agent 1 2). X-ray crystallographic analysis provided evi- dence for the compound 2 to be free hypervalent tellurium cation without any interaction with - the counter anion, (C6F5)4B , in the crystalline state. Furthermore, in catalyzed olefin polymerization, a number of catalysts have been re- - ported where the catalytic activity is due to the “free” cation when the anion used was (C6F5)4B - 3) in place of Ph4B .

References 1) Pentafluorophenylboranes W. E. Piers, T. Chivers, Chem. Soc. Rev., 26, 345 (1997). + 2) Synthesis and characterization of a stable nonclassical onium compound, Ph5Te M. Minoura, T. Mukuda, T. Sagami, K. Akiba, J. Am. Chem. Soc., 121, 10852 (1999). 3) Polymerization of propylene by zirconocenium catalysts J. C. W. Chien, W.-M. Tsai, M. D. Rausch, J. Am. Chem. Soc., 113, 8570 (1991). J. C. W. Chien, W. Song, M. D. Rausch, J. Polym. Sci. Part A: Polym. Chem., 32, 2387 (1994).

LITHIUM ION-SELECTIVE ELECTRODE

D2565 2,9-Di-n-butyl-1,10-phenanthroline 1g JPYen 25,300 100mg JPYen 4,600

N + N N Li + 2 Li N N N

1 Ion-selective electrodes have been widely used in medicine as a tool for measuring alkali and alkaline earth metal ions in blood. This method, using the ion-selective electrodes, is excel- lent in simplicity and economy because the target ions are determined by simply immersing the electrode into the sample without any pretreatment. Much attention has also been focused on Li+-selective electrodes. The 1,10-Phenanthroline derivative 1 is a neutral carrier for lithium ion-selective electrodes. PVC membrane electrodes based on 1 exhibit excellent Li+-selectivity and the selectivity coefficients for Li+ relative to the other metal ions are: Na+(-3.1), K+(-3.3), Ca2+(-3.2), Mg2+(-3.0)(logK). These values are similar or higher than those with 14-crown-4 derivatives which have been under study for some time. Therefore an electrode based on 1 is a good candidate for clinical applications.

References 1) H. Sugihara, T. Okada, K. Hiratani, Anal. Sci., 9, 593 (1993). 2) T. Katsu, Farumashia, 31, 175 (1995). 25 January, 2000 number 105

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