Sponsored by the International Biometric Society

Sponsored by the International Biometric Society The International Biometric Society is devoted to the development and application of statistical and mathematical theory and methods in the biosiciences.

The Conference is grateful for the support of the following organisations:

The Federation of Pharmaceutical Manufacturers' Associations of JAPAN Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

Contents

List of Sponsors Inside Front Cover

Welcome from Presidents Page 2

Welcome from Chairs Page 3

Programme at a Glance Page 4 - 6

Opening Session Page 7

IBC2012 Governance Meetings Schedule Page 8

Organising Committees Page 9

Awards at IBC Kobe 2012 Page 10

General Information Page 11

Venue Information Page 12

Presentation Instruction Page 13

Social Programme Page 15

Mid-Conference Tours Page 16

Scientiﬁ c Programme Page 21

Satellite Symposium Page 46

Map of KICC Page 60

Access Map Page 61

Floorplan Page 62

1 XXVIth International Biometric Conference

Message from the IBS President and the IBC 2012 Organising President

It is with great pleasure that we welcome all delegates, their families and friends to the XXVIth International Biometric Conference (IBC 2012) being hosted by the Japanese Region in Kobe. It is nearly thirty years since they hosted the one previous IBC held in Japan in Tokyo in 1984.

Toshiro Tango and his Local Organising Committee (LOC) have done a wonderful job in providing a socially and scientifi cally inviting program at an outstanding venue. The Kobe International Convention Centre provides excellent spaces for formal meetings/scientifi c sessions and informal conversations/ networking activities which are an essential part of every IBC. The task of the LOC was made particularly diffi cult after the natural disaster which stuck northern Japan in early 2011. The Japanese Region very much appreciated the concern shown by members from around the world for their welfare under incredibly diffi cult conditions. The national recovery effort has been immense in both size and duration, so delegates are encouraged to visit other parts of Japan to show their support for these courageous people.

Christine McLaren and her International Program Committee (IPC) have contributed to the scientific program by selecting 14 invited sessions which are spread throughout the week. We have also scheduled Biometrics and JABES Showcases, a Young Statisticians Showcase, a Special Invited Session from the ISI, and many sessions containing contributed talks. The end result is that members will have much choice in selecting talks and/or posters of interest to them. This is over and above Sunday’s workshops which were organised by the Education Committee.

In addition to the above, we are grateful to the continued support of our Executive Director Dee Ann Walker and her colleagues at the IBS International Business Office in overseeing the submission of abstracts and helping us to manage the society is much appreciated.

We are looking forward to renewing international friendships and professional contacts and making new ones during the next week. Hopefully, many of you will also join us in Florence Italy for the XXVIIth International Biometric Conference in 2014.

We wish you all an enjoyable and productive time.

Clarice G.B. Demétrio Kaye E. Basford President Organising President International Biometric Society IBC 2012 Kobe

2 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

Message from the Chair of the International Programme Committee

Welcome to the XXVIth International Biometric Conference, the biennial meeting of the International Biometric Society. The scientifi c program consists of 14 invited sessions, fi ve special sessions, and over 40 contributed oral sessions. In addition, four short courses will be offered and scientifi c posters will be on display throughout the conference.

We thank the International Business offi ce, the organizing President, Kaye Basford, and the President, Clarice Demetrio. In particular we would like to thank Yutaka Matsuyama, who worked with us to build the scientifi c program, and the Local Organizing Committee, who assumed responsibility for the fi nal program schedule and local infrastructure arrangements, under the leadership of Toshiro Tango.

The meeting will be held at the Kobe International Conference Center. Kobe, located between the sea and the Rokko mountain range, is known as an attractive and cosmopolitan port city. We are grateful to our hosts, the Biometric Society of Japan and the Japanese Region of the IBS, for arranging this excellent venue that promises to encourage scientiﬁ c, social, and cultural interchanges among our diverse membership.

We welcome you to the meeting.

Christine McLaren Chair, International Programme Committee

Message from the Chair of the Local Organising Committee

We are pleased to announce that the XXVIth IBC is to be held in Kobe, Japan as scheduled. After the unprecedented earthquake and tsunami followed by the nuclear plant accident in Fukushima, we have received many sincere condolences for Japanese people. First of all, we would like to express our heartfelt gratitude to you. We have received comments from colleagues overseas who are concerned about the safety of holding the Conference in Japan. However, Kobe is located more than 600 kilometers away from the affected area and so all is well and everything is functioning properly.

The first IBC to take place in Asia was held in Tokyo in 1984 and the prosperity of this field has indeed been conspicuous since that event. We are conﬁ dent that the XXVIth IBC will witness the passing of the baton from our illustrious predecessors to the next generation of researchers who will further advance our understanding of biometrics and extend their applications in related ﬁ elds. As always, it will bring together participants from all over the world working in academic institutions, government agencies, and industry to exchange ideas on the latest advances in biometry, biostatistics and bioinformatics. It will also be an occasion to meet old and new friends, and the chance to visit historical cities such as Kobe, Kyoto and Nara.

We are very much looking forward to seeing you all in Kobe!

Toshiro Tango Chair, Local Organising Committee

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Programme at a Glance

26 August (Sunday) 27 August (Monday) 09:00 Short Course 09:00 Opening Session 10:30 Coffee Break 11:00 Scientiﬁ c Session 1 Invited Session 1: Novel Statistical Methodology and Its Application in Marine Ecology and Fisheries Research Short Course 1: Group Sequential and Adaptive Contributed 1: Analysis and Interpretation of Clinical Methods for the Design of Clinical Trials Trial Data Contributed 2: Analysis of Medical/Clinical Data Contributed 3: Missing Data and Imputation Contributed 4: Distribution and Statistical Inference

Short Course 2: Joint Modeling Approaches in 12:45 Lunch Longitudinal Studies Using Random Effects 14:00 Scientiﬁ c Session 2 Invited Session 2: The Landmark Approach to Event History Analysis Invited Session 3: Statistical Challenges in the Analysis of Rare Genetic Variants in Association Studies Short Course 3: Clinical Trial Data Analysis Using R Contributed 5: Nested Case-Control Study Contributed 6: Pharmacokinetic and Pharmacodynamic Studies Contributed 7: Sampling Method Poster Presentation 1 Short Course 4: Identifying Genes for Complex and Mendelian Traits Using Next Generation Sequence Data 15:45 Coffee Break 16:15 Scientiﬁ c Session 3 Biometrics Showcase Session Contributed 8: Cancer Clinical Trial Contributed 9: Longitudinal Data: Modeling Contributed 10: Analysis of Ecological Data (1) Lunch & Coffee Break during Sessions * Contributed 11: Categorical Data 17:00 Welcome Reception Poster Presentation 1

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28 August (Tuesday) 29 August (Wednesday) 08:45 Scientifi c Session 4 Invited Session 4: Advances in Spatial Latent Variable Modeling with Applications to Bio-Sciences Contributed 12: Clinical Trials: Design Issues (1) Contributed 13: Analysis of Genetic Data (1): GWAS Contributed 14: Agriculture Research (1) Contributed 15: Multiple Testing Poster Presentation 2 10:30 Coffee Break 11:00 Scientifi c Session 5 Invited Session 5: New Developments in Statistical Ecology Contributed 16: Clinical Trials: Design Issues (2) Contributed 17: Analysis of Genetic Data (2) Contributed 18: Agriculture Research (2) Contributed 19: Classifi cation and Mixture Distribution Poster Presentation 2 12:45 Lunch 14:00 Scientifi c Session 6 Mid-Conference Tours Invited Session 6: Approximate Bayesian Computation (ABC) and Likelihood-Free Inference Invited Session 7: Novel Mixture Modeling and Likelihood Methods in Modern Biomedical Applications Contributed 20: Analysis of Genetic Data (3) Contributed 21: Causal Inference (1) Contributed 22: Analysis of Ecological Data (2) Poster Presentation 3 15:45 Coffee Break 16:15 Scientifi c Session 7 JABES Showcase Session Contributed 23: Meta-Analysis Contributed 24: Bayesian Modeling and Biological Network Contributed 25: Causal Inference (2) Contributed 26: Analysis of Ecological Data (3) and Saturation Mutagenesis Poster Presentation 3 18:15 IBS General Meeting and Awards Presentation

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30 August (Thursday) 31 August (Friday) 08:45 Scientifi c Session 8 08:45 Scientifi c Session 12 Invited Session 8: HER Databases and Long Term Invited Session 12 Statistical Methods for Reducing Observational Studies in the Study of Quality of Care Batch Effects, Summarization and Gene Filtering in Assessment and Risk Factors for Outcomes – Bayesian High-Throughput Genomic Data and Frequentist Methods and Limitations on Inference Fisher’s 50th Memorial Session Contributed 27: Modeling and Analysis of Infectious Disease Contributed 41: Survival Analysis: Inference Contributed 28: Survival Analysis: Interval Censoring Contributed 42: Application of Bayesian Method in Contributed 29: Analysis of High-Dimensional Data (1) Medical/Epidemiological Research Contributed 30: Spatial Data Analysis (1) Contributed 43: Optimal Design and Related Topics Poster Presentation 4 10:30 Coffee Break 10:30 Coffee Break 11:00 Scientifi c Session 9 11:00 Scientifi c Session 13 Invited Session 9: Data Visualization: Optimization Invited Session 13: International Collaborations and Applications and Networking of the Biometricians to Develop ISI Special Invited Session: Statistical Methods Statistical Methodologies and to Solve Global of Risk Assessment on the Health Effect of the Statistical Issues Environment Contributed 44: Disease Monitoring and Screening Contributed 31: Survival Analysis: Competing Risks Contributed 45: Survival Analysis: Modeling (1) Contributed 32: Analysis of High-Dimensional Data (2) Contributed 46: Analysis of Multidimensional Contributed 33: Spatial Data Analysis (2): Application Biomarker and Data Mining (2) Poster Presentation 4 Contributed 47: Mixed/Random Effects Model 12:45 Lunch 12:45 Lunch 14:00 Scientifi c Session 10 14:00 Scientifi c Session 14 Invited Session 10: Design and Analysis of Clinical Invited Session 14: Statistical Methods for Trials for Predictive Medicine: New Paradigm and Analyzing Neurophysiological Signals Challenges Contributed 48: Modeling and Analysis of Clinical Contributed 34: Analysis of Imaging Data Research Data Contributed 35: Modeling and Analysis of Contributed 49: Survival Analysis: Modeling (2) Environmental Data Contributed 50: Mixed Effects Model and Reliability of Contributed 36: Analysis of High-Dimensional Data (3) Diagnosis Contributed 37: Species Abundance/Biodiversity Poster Presentation 5 15:45 Coffee Break 15:45 Coffee Break 16:15 Scientifi c Session 11 16:15 Closing Session Invited Session 11: Exposure Reconstruction and Exposure Uncertainty in Epidemiological Studies of Radiation Health Effects Young Statisticians Showcase Session: This is a newly added program for the IBC Kobe in 2012. Currently an MSc or PhD candidate or graduated with one of these degrees in 2010 or 2011 were eligible to enter the competition ! Five papers(one each from Africa, Asia, Europe, North America and South America) have been selected for presentation in the Showcase. Contributed 38: Longitudinal Data: Analysis Contributed 39: Analysis of Multidimensional Biomarker and Data Mining (1) Contributed 40: Diagnostic Test Poster Presentation 5 18:30 Conference Dinner

6 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

Opening Session

Date: Aug. 27, 2012 (Monday) 9:00-10:30 Room: Kobe International Conference Center Main Hall

9:00-9:05 Opening Remarks and Introduction of Attendees Kazue Yamaoka (MC)

9:05-9:15 Introduction of IPC Members and Invited Talks Christine McLaren (IPC Chair)

9:15-9:35 Welcome from the LOC Chair and General Information for Participants Toshiro Tango (LOC Chair)

9:35-9:40 Welcome from Organising President Kaye Basford (Organising President)

9:40-10:00 International Biometric Society Presidential Address Clarice Demétrio (IBS President)

10:00-10:05 Welcome from the Japanese Region President Tosiya Sato (JR President)

10:05-10:10 Message from Science Council of Japan Fumiko Kasuga (Vice President of Science Council of Japan)

10:10-10:13 Message from the Prime Minister of Japan Kazue Yamaoka (MC) (read for the Prime Minister Yoshihiko Noda)

10:13-10:15 Closing Remarks Kazue Yamaoka (MC)

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IBC2012 Governance Meetings Schedule

Date/Time Committee Room

26 (Sunday)

09:00 – 12:30 Executive Committee (#406) 13:00 – 16:30 Council and Representative Council (#505)

27 (Monday)

14:45 – 15:45 All Committee Chairs with CD, KB, LY (#406) 16:15 – 18:00 Finance Committee (#404) 16:15 – 18:00 Education Committee (#406) 18:00 – 19:30 Reception for Regional Ofﬁ cers (#406)

28 (Tuesday)

08:45 – 10:30 Club of Presidents (#302) VIP room 11:00 – 12:45 Biometrics Associate Editors (#505) 14:00 – 15:45 Editorial Advisory Committee (#404) 14:00 – 15:45 Awards Fund Committee (#406) 16:15 – 18:00 Conference Advisory Committee (#404) 16:15 – 18:00 Strategic Issues Committee (#406)

30 (Thursday)

08:45 – 10:30 Council and Representative Council (#505) 11:00 – 12:45 Regional Presidents (#406) 14:00 – 15:45 Communications Committee (#406) 16:00 – 17:00 LOC 2014 + LOC2012 Chair (#505) 17:00 – 18:00 IPC 2014 + IPC2012 Chair/Short Course Coordinator (#505)

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Organising President

Kaye E. Basford, University of Queensland, Australia

International Programme Committee

Chair: Christine McLaren (Western North American Region)

Members: Yasuo Ohashi (Japanese Region, LOC-PC Chair) Taerim Lee (Korean Region) Dalton de Andrade (Brazilian Region) Xihong Lin (Eastern North American Region) Kaye Basford (Australasian Region, IBS President) Raúl Macchiavelli (Central America-Caribbean Region) Hendriek Boshuizen (The Netherlands Region) Yutaka Matsuyama (Japanese Region) Frank Bretz (German Region) Geoffrey McLachlan (Australasian Region) Reﬁ k Burgut (Eastern Mediterranean Region) Stephan Morgenthaler (Austro-Swiss Region) Tim Cole (British and Irish Region) Vicente Núñez-Antón (Spanish Region) María Durbán Reguera (Spanish Region) Ranganath Rattihalli (Indian Region) Zoﬁ a Hanusz (Group Poland) Julio A. Di Rienzo (Argentinean Region) Hélène Jacqmin-Gadda (French Region) Maria Grazia Valsecchi (Italian Region) Esa Läärä (Nordic Region) Stijn Vansteelandt (Belgian Region)

Local Organising Committee

Chair: Toshiro Tango (Japanese Region)

Members: Chikuma Hamada (Japanese Region) Toshihiko Morikawa (Japanese Region) Yukio Hatoyama (Japanese Region) Yasuo Ohashi (Japanese Region) Manabu Iwasaki (Japanese Region) Takashi Omori (Japanese Region) Hirohisa Kishino (Japanese Region) Tosiya Sato (Japanese Region) Thomas Louis (Eastern North American Region) Hiroe Tsubaki (Japanese Region) Yutaka Matsuyama (Japanese Region) Hiroyuki Uesaka (Japanese Region) Mihoko Minami (Japanese Region) Kazue Yamaoka (Japanese Region) Tetsuhisa Miwa (Japanese Region) Hao Yan (Japanese Region)

Conference Organisations

The Biometric Society of Japan, Japanese Region of the International Biometric Society The Science Council of Japan IBS International Business Ofﬁ ce, Washington DC, USA

Supporting Organisations

Japanese Society of Applied Statistics Japan Statistical Society Pharmaceuticals and Medical Devices Agency Foundation for Biomedical Research and Innovation The Institute of Statistical Mathematics 9 XXVIth International Biometric Conference

Awards at IBC Kobe 2012

Best Student Oral Paper at the IBC (2 students)

Aim: To encourage the participation of students in the oral programme at the IBC, and improve the quality of scientifi c communication. Prize: Certifi cate, Wiley book gift coupon ($100). Eligible: Any oral paper presented by a student at the conference (the student should be a member of the IBS). Application: At the point of submission of the abstract (with certifi cation of student status – as usually required for registration). Timetable: Application at abstract submission; Judging during oral sessions at the IBC; Presentation at the closing session of the IBC. Selection: By selection through a small ad-hoc committee drawn from the organising committees. Judgment to be based on scientifi c content and the good quality of the oral and visual presentation.

Best Poster Presentation at the IBC (2 presenters)

Aim: To promote the use of poster presentations and encourage the participation of all delegates in the poster sessions. Prize: Certiﬁ cate, Wiley book gift coupon ($100) Eligible: Any poster presentation accepted for presentation during a poster session (the author should be an IBS member) . Application: At the point of submission of the abstract. Timetable: Application at abstract submission; Judging during poster sessions at the IBC; Presentation at the closing session of the IBC. Selection: By selection through a small ad-hoc committee drawn from the organising committees. Judgment to be based on scientiﬁ c content and the good use of the poster format.

Travel Awards for IBC 2012

Travel funds may be available to eligible IBS members to attend our IBC2012.

Young Statistician Showcase

This is a newly added program for the IBC Kobe in 2012. Currently an MSc or PhD candidate or graduated with one of these degrees in 2010 or 2011 were eligible to enter the competition ! Five papers(one each from Africa, Asia, Europe, North America and South America) have been selected for presentation in the Showcase.

10 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

General Information

Registration Opening Hours Sunday, Aug.26 8:00-17:00 Monday, Aug.27 8:00-18:30 Tuesday, Aug.28 8:00-18:30 Thursday, Aug.30 8:00-17:00 Friday, Aug.31 8:00-15:00

Registration Desk Event Hall on the 3rd ﬂ oor, Kobe International Conference Center (KICC) Registration Fee Coverage Type Conference Programme Session Welcome Lunch Transportation* Pack book (Exhibition, Reception (On-line Coffee break etc) Registration Only) IBS Member ○○○○○○ IBS Non-Member ○○○○○○ Student ○○○○○○ Accompanying Person ○○ *For those who reserved the accommodation from the conference official website, Round Port Liner tickets for 4 days will be provided. Except person(s) who is staying at Kobe Portpia Hotel, Quality Hotel and Hotel Pearl City Kobe :( These 3 hotels are located within walking distance)

You will be provided with a name badge when you register at Registration Desk. To register for Student/Trainee Tickets, you are required to present your student ID card or English student certiﬁ cate issued by your university or academic institution. All delegates are requested to wear their name badges at all times within the Congress venue.

Certificate of Attendance A certiﬁ cate of attendance will be handed at Registration Desk.

Exhibition A commercial exhibition will be held at Reception Hall on the 3rd ﬂ oor.

Opening Hours Monday, Aug.27 9:00-18:00 Tuesday, Aug.28 9:00-18:00 Thursday, Aug.30 9:00-18:00 Friday, Aug.31 9:00-14:00

Lunch Boxed lunch will be served upon request of advance application.

Meeting Policies - Photographing and audio recording without permission are prohibited. - Please set your cell phones into silent mode or turn off during the sessions. - Eating and drinking during the sessions are prohibited at Main Hall (1F) and International Conference Room (3F).

11 XXVIth International Biometric Conference

Venue Information Secretariat Office Secretariat Ofﬁ ce is located at Room 304 on the 3rd ﬂ oor.

Baggage Room Baggage Room is located at Room 307 on the 3rd ﬂ oor. Valuables cannot be left at Baggage Room.

Opening Hours Sunday, Aug.26 8:30-19:00 Monday, Aug.27 8:30-18:30 Tuesday, Aug.28 8:30-18:30 Thursday, Aug.30 8:30-18:30 Friday, Aug.31 8:30-17:30

Internet Corner Computers are available at Room 407 on the 4th ﬂ oor.

Opening Hours Sunday, Aug.26 8:00-17:00 Monday, Aug.27 8:30-18:30 Tuesday, Aug.28 8:30-18:30 Thursday, Aug.30 8:30-17:00 Friday, Aug.31 8:30-15:00

Message Board Message Board is located beside Registration Desk. Please make sure to remove the message by yourself.

Lost and Found Please visit Registration Desk for lost and found.

Foreign Exchanges and Travelers Checks Foreign Exchanges services are available at the front desk of Kobe Portopia Hotel (on the south side of KICC).

Travel Desk Travel desk is not located on site. Please contact below address; Ofﬁ cial Travel Agency: JTB Western Japan Corp. Communication Division [26th International Biometric Conference] Desk Phone: +81-6-6252-2861 Fax: +81-6-6252-2862 E-mail: [email protected] Ofﬁ ce hours: 9:30 - 17:30 (weekdays only)

Taxi Taxi Berth is located in front of the main entrance of Kobe Portopia Hotel.

Smoking Areas Smoking is banned in all facilities.

12 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

Presentation Instruction

Information for Chairs Please be seated in the Chairs'seats located at the front right of your session room at least 15 minutes prior to your session starts.

【Oral Presentations】 Information for Presenters 1) Please note that all contributed oral presentations have been allocated 15 minutes for presentation plus 2 minutes for questions, and session chairs will be instructed to stop any presentations that over-run to be fair to those giving presentations later. 2) Please prepare your data either in Microsoft PowerPoint(2007/2010) or PDF format created by LaTex or Windows Word etc., and please preview your presentation data at PC Center 1 hour prior to your presentation. As for the speakers of the ﬁ rst session on each day, please come to PC center the day before prior to your presentation. 3) Remote presentation system is equipped in the each session room. You have a TFT monitor, mouse and USB keyboard on the podium to operate your presentation. 4) Audio playback is not possible.

PC Center PC Center is located at Entrance Hall on the 3rd ﬂ oor.

Opening Hours Sunday, Aug.26 8:00-17:00 Monday, Aug.27 8:00-18:30 Tuesday, Aug.28 8:00-18:30 Thursday, Aug.30 8:00-17:00 Friday, Aug.31 8:00-15:00

If you use the Secretariat’s PC 1) Only USB fl ash memories and CD-R are accepted. MOs, fl oppy disks, DVD and CD-RWs cannot be accepted. 2) Windows (Windows XP) is the only operating system available for the presentations. (If you have prepared the presentation data on a Macintosh, you are advised to bring your own computer). 3) Only Windows Media Player can be used to playback movie fi les. 4) Your media should contain only the presentation data for the Conference. 5) Your presentation data file should be named as .ppt./pdf. Ex: Invited Session_ FirstnameFamilyname.ppt./pdf. 6) If your presentation data is linked to other fi les (i.e. still or moving images, graphs, etc.), those linked fi les should also be saved in the same folder, and the links checked beforehand. 7) The Secretariat is responsible for destroying all copies of any data after the session.

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If you bring your own PC 1) The Secretariat will prepare a Mini D-sub 15 pin PC cable connector. If your PC is not compatible with this cable connector, please bring an adaptor to connect your PC to the Mini D-sub 15 pin PC cable connector. 2) Please bring your AC adapter with you. 3) The resolution of the LCD projector is XGA (1024 x 768). If your computer requires a resolution setting to be changed, please change this setting beforehand. 4) Please also bring your presentation data on a media (either on USB flash memory or CD-R) as a backup ﬁ le. 5) After checking your data at PC Center, please bring your PC to the Operation Desk in the session room 30 minutes prior to the start time of your session. 6) Following the conclusion of your session, we will return your computer at the Operation Desk. Please come to Operation Desk promptly to collect it.

Session No. Presentation Title, Name(s) 【 Poster Presentations】 (to be completed of Author(s), Institution by Secretariat) (to be completed by Presenter) Preparing Your Posters W200mm x H200mm W1000mm x H200mm 1) Poster size - The size of the poster panel is W1200 mm x H2100 mm. Please prepare your posters to ﬁ t in this size. Each presenter W1200mm×H1900mm is responsible for preparing their posters with the title, name(s) of author(s) and institution(s). - The Secretariat will prepare the poster panel and pins. Please do not use any tape etc. that is not provided by the Secretariat. 2) The Secretariat will prepare a panel with your poster number. 3) Please prepare this slip with title, name(s) of author(s), and institution. Poster Discussion 1) Guidelines Discussions should be held in front of your posters. Participants will be free to view the posters and to discuss with presenters during the designated time (free discussion style). During the following times, please be in front of your poster to answer any questions from the participants. 2) Schedule Poster Presenters are asked to place their posters at the designated space and to follow the schedule below.

Poster Session Day Mounting Presentation Removal Poster No. 1 Monday, Aug.27 13:00-14:00 14:00-18:00 P-1-1 ～ 31 2 Tuesday, Aug.28 8:45-12:45 P-2-1 ～ 30 3 Tuesday, Aug.28 14:00-18:0018:00-18:30 P-3-2 ～ 30 8:00- 8:45 4 Thursday,Aug.30 8:45-12:45 P-4-1 ～ 30 5 Thursday,Aug.30 14:00-18:00 P-5-1 ～ 32 Any materials left behind after the removal time shall be cleaned up by the Secretariat. Change and Withdrawal Any change and withdrawal of submitted papers notifi ed after the fi nal programme, will be announced both in the scientifi c programme page on the website and the information board on-site. 14 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

Social Programme Sunday, Aug. 26 Welcome Reception on the 3rd ﬂ oor, Kobe International Conference Center Wednesday, Aug. 29 Range of social excursions (one-day)

Conference Dinner - 30th Thursday August 18:30 - 21:00 The Conference Dinner will be held at Kobe Kachoen, a theme park that you can see a variety of birds in the midst of ﬂ owers all the year around, in a huge completely air-conditioned greenhouse. It is located in front of "K Computer Mae" station of "Port Liner Airport Line", which is two stops from "Shimin Hiroba" station next to the Kobe Conference Center.

Please take part with your family and friends to celebrate this memorial gathering and relaxation where you will be able to experience the Japanese traditional arts through the "Maiko" dance performance of Kyoto, and "Mochi-tsuki", a rice cake making show, a traditional celebratory occasion wishing happiness, health and welfare. Furthermore, you can enjoy an exciting live performance of a band (some players will be participants !! ).

Let's enjoy ! Cost: 7,000 yen (includes dinner, drinks, entertainment and Port liner tickets) Costume: informal (shorts, t-shirts, …)

Access Map

Access -Port Liner Railway Take a port liner bound for Kobe Airport from the venue. It is just 2 Conference Venue stops from Shimin Hiroba.

Kacho-en -Taxi Conference Dinner 10 minutes from the venue. It costs around 1,000 yen.

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Mid-Conference Tours Gathering spot: Kobe Portpia Hotel, in front of the entrance of the main building (B1F). Gathering time: 10minutes before the departure time. *note: If the minimum passenger count for each course is not met, it will not run and all fees will be refunded in full to each applicant. No registration on site.

(Tour 1) Kobe Culture course

Minimum number of participants : 40 persons Price: 5,000 yen From 8:30 am to 3:00 pm Itinerary: Portopia hotel - Minatogawa shrine - Hakutsuru sake brewery museum - Kobe shushinkan brewery (Lunch) - Disaster Reduction and Human Renovation Institution - Portopia hotel Include: transportation fee by chartered bus, Lunch, entrance fee and English guide.

[Minatogawa shrine] Exhibits numerous treasures of Kusunoki Masashige who is enshrined here, including some important cultural properties, e.g. his hand-copied Buddhist sutras and his bellyband. [Hakutsuru sake brewery museum] Original brewing equipment exhibited in a wooden sake cellar established in he Taisho era. Try fresh unreﬁ ned sake on the house. [Disaster Reduction and Human Renovation Institution] Facilities established in memory of Hanshin-Awaji Earthquake to contribute to disaster prevention and damage reduction.

(Tour 2) Kobe Resort course

Minimum number of participants : 40 persons Price: 5,500 yen From 9:00 am to 4:30 pm

16 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

Itinerary: Portopia hotel - Hall of halls Rokko - Rokko garden terrace - Lunch - Arima hot-spring - Portopia hotel Include: transportation fee by chartered bus, Lunch, entrance fee and English guide.

[Hall of halls Rokko] "Hall of Halls Rokko" is a museum of music boxes. There are mainly Cylinder and Disk music boxes made in America or Europe in the 19th to the early 20th century. Also, there are some kinds of automatic musical instruments include the Dance Organ that is one of the world's largest. There are 14 concerts held in a day with varieties of instruments and numbers. You can enjoy the concert with the explanation by staffs. [Arima hot-spring] Arima Onsen is a popular tourist destination where visitors can experience Japanese culture, walking around this elegant town with many hot springs, shrines and temples. The changing seasonal scenery and the local cuisine makes Arima an appealing destination.

(Tour 3) Rokko Hiking course

Minimum number of participants : 10 persons Price: 8,000 yen From 9:00 am to 3:00 pm Itinerary: Portopia hotel - Rokko garden terrace - (hike) - Top of Rokko mountain - Lunch - Portopia hotel *Schedule is subject to change on very short notice based on weather. Include: transportation fee by chartered bus, Lunch, entrance fee and English guide. What to bring: *comfortable clothes and shoes *Sun hat, sun glasses *Water

[Rokko Garden Terrace] Complex facilities consisting of cafe, restaurants and accessory shops opened at the top of Mt. Rokko. You can see a panorama of Kansai International Airport to Akashi Kaikyo Bridge on the observatory space. Also you can enjoy the night view. [Rokko mountain] Mt. Rokko, the symbols of Kobe, have been loved by the locals as great mountain leisure areas through the ages.

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(Tour 4) Ijinkan Foreign Residences course

Minimum number of participants : 40 persons Price: 4,000 yen From 9:00 am to 3:30 pm Itinerary: Portopia hotel - Kitano area (Free) - Portopia hotel Include: transportation fee by chartered bus.

[Kitano area] The Kitano area is dotted with residences built by foreigners who arrived in Kobe after the port opened is a popular sightseeing area. Mt. Maya, which is directly behind Shin-Kobe Station, the shinkansen station, is a great spot to experience nature so close to town.

(Tour 5) Nara course

Minimum number of participants : 40 persons Price: 8,000 yen From 8:30 am to 5:00 pm Itinerary: Portopia hotel - Todaiji temple - Kasuga grand shrine - Lunch - Horyuji temple - Portopia hotel Include: transportation fee by chartered bus, Lunch, entrance fee and English guide.

[Todaiji temple] The Todaiji Temple is the representative temple of Nara. The principal image of worship there is the Daibutsu(Grreat Buddha), the 1,250 year old sitting image of Vairocana(Rush -ana-Butsu-zaso. This bronze Buddhaaffectionately known as Daibutsu-san, measures approximately 15m(49.5ft) in height, and weighs about 250t, with a face that measures 5m(16.5ft) in width.

18 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

[Kasuga grand shrine] Built as the family shrine of the Fujiwara Family, Kasuga Shrine has become famous for its graceful wisteria blossomes which almost sweep the ground at the south side of Utsushidono Hall. The rows fo approximately 2,000 stone lanterns along the pathways, and the over 1,000 hanging lanterns of the Main Hall and cloister create a breathtaking spectacle of lights. [Horyuji temple] Horyuji Temple's ﬁ ve-storied pagoda, the main hall and Chumon(middle gate are the world's oldest wooden structures, constructed in the late 7th century. Their gentle roof lines are beautiful and are complimented by the atmosphere of Ikarugano-sato (the region of Ikaruga).

(Tour 6) Kyoto course

Minimum number of participants : 30 persons Price: 12,000 yen From 8:00 am to 6:00 pm Itinerary: Portopia hotel - Kinkakuji temple - Nijo castle - Lunch - Heian Shrine (From the bus'swindows) - Kiyomizu temple - Portopia hotel Include: transportation fee by chartered bus, Lunch, entrance fee and English guide.

[Kinkakuji temple] It is perhaps the most widely-recognized image of Kyoto. Seen refl ected in the adjoining "mirror pond" with its small islands of rock and pine, Kinkaku-ji Temple, "The Temple of the Golden Pavilion," is a breathtaking must-see. The building's fi rst purpose was to serve the retiring Shogun Ashikaga Yoshimitsu (1358-1409) as a residence. The gold-leaf-adorned building was converted into a Zen temple shortly after his death. In an event that was later fi ctionalized by the renowned author Yukio Mishima, a 21-year-old monk burned Kinkakuji down in 1950. The temple was rebuilt in 1955 and continues to function as a storehouse of sacred relics. [Kiyomizu temple] Kiyomizu-dera Temple is perhaps the most beloved of Kyoto's temples and is a fi xture in the minds of the Japanese people. The temple's veranda juts out of the side of a mountain supported by 13-meter- high wooden columns. The main hall with its distinctive hip-shaped roof of cypress bark rests to the rear of the veranda and houses within it a priceless statue of Kannon Bodhisattva, the goddess of mercy. From the veranda, one can appreciate fi ne views facing west over the city of Kyoto.

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(Tour 7) Osaka course

Minimum number of participants : 30 persons Price: 12,000 yen From 8:30 am to 4:00 pm Itinerary: Portopia hotel - Osaka castle - Aqua Liner (Osaka river cruise) - Lunch - City sightseeing (Free) - Portopia hotel Include: transportation fee by chartered bus, Lunch, entrance fee and English guide.

[Osaka castle] Osaka Castle Park opened in 1931 and covers an area of 106.7 hectare. Osaka Castle Park is colorfully embellished. You can see about 600 cherry trees, including someiyoshino in Nishinomaru Garden. About 95 kinds of Japanese apricot ﬂ owers,1250 trees in total bloom in Ume Grove, and in Omoide-no-mori (Grove of Remembrance), you can enjoy beautiful autumn colored leaves. The scenery, which changes from season to season, attracts many visitors throughout the year. Although the castle park is located in the center of the city, it is a place of recreation and relaxation familiar to Osakans. [Aqua Liner] Aqua-Liner, an aqua-bus touring Osaka's Okawa River, the Water Capital. Enjoy yourself while viewing Japanese esthetic scenery reﬂ ected on the surface of Okawa River during the changes season to season.

Accompanying Person Programme The accompanying person’s programme includes attendance to the Welcome Reception, Coffee Breaks, a ticket for accompanying person’s tour. Price: 5,000 yen

Accompanying person's tour ( Free of charge / First 50 applicants ) On-site application will be available at the inquiry desk until 11:00 am 28th. Date: 28th August ( Tuesday ) From 13:00 pm to 17:30 pm Itinerary: Portopia Hotel - Kobe City Museum - China Town - Sourakuen ( Japanese Garden ) - Portopia Hotel

20 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

27 August (Monday): 09:00-10:30

09:00 Opening Session Main Hall

27 August (Monday): 11:00-12:45 11:00 Invited Session 1 : Novel Statistical Methodology and Its Application in Marine Ecology and International Fisheries Research conference Organisers : Mihoko Minami(Keio University, Japan), room Cleridy E. Lennert-Cody(Inter-American Tropical Tuna Commission, USA) Chair : Cleridy E. Lennert-Cody 11:00 I-1-1 : Mark Bravington(CSIRO Mathematical and Information Sciences Marine Laboratories, Australia) Close-Kin Genetics for Fisheries Assessment and Management: Two Examples 11:25 I-1-2 : Hans J. Skaug(University of Bergen, Norway) Inferring Demographic Structure in Whales from DNA Proﬁ les 11:50 I-1-3 : Toshihide Kitakado(Tokyo University of Marine Science and Technology, Japan) Estimation of Spatial and Temporal Population Mixture Using Genetic and Morphometric Data 12:15 I-1-4 : Simon N. Wood(University of Bath, UK) Spatial Components in Smooth Ecological Models 12:40 General Discussion and Questions

11:00 Contributed 1 : Analysis and Interpretation of Clinical Trial Data #501 Chair : Hiroyuki Uesaka(Osaka University, Japan) 11:00 C-1-1 : Yoko Tanaka(Eli Lilly and Company, USA) Points to Consider in Deﬁ ning Region and Consistency Assessment in Multi-Regional Clinical Trials from PhRMA Key Issue Team 11:17 C-1-2 : Andreas Kitsche(Institut für Biostatistik, Leibniz Universität Hannover, Germany) Assessment of the Heterogeneity of the Treatment Effect among Subgroups by Detecting Qualitative Interactions 11:34 C-1-3 : Takashi Funatogawa(Chugai Pharmaceutical Co., Ltd., Japan) Analysis of Covariance in Randomized Clinical Trials with Pre- and Post-Treatment Measuremtnets 11:51 C-1-4 : Alice Parry(Medical and Pharmaceutical Statistics Research Unit, Lancaster University, UK) Analysing Malaria Trials on a Per Clone Basis: A New Approach 12:08 C-1-5 : Holly Janes(Fred Hutchinson Cancer Research Center, USA) A Cost-Beneﬁ t Framework for Evaluating Candidate Treatment Selection Biomarkers

11:00 Contributed 2 : Analysis of Medical/Clinical Data #502 Chair : Christine E. McLaren(The University of California, USA) 11:00 C-2-2 : Christine E. McLaren(The University of California, USA) Bivariate Mixture Modelling with Longitudinal Evaluation of Component Stability 11:17 C-2-3 : Jamshidian Farid(University of California-Berkeley, USA) Joining Forces for Risk Prediction in Medicine: An Ensemble Risk Prediction Model for Breast Cancer 11:34 C-2-4 : Ivonne Solis-Trapala(MRC Human Nutrition Research, UK) Graphical Models with Latent Variables and Their Application in Neuropsychology 11:51 C-2-6 : Stefania Galimberti(Center of Biostatistics for Clinical Epidemiology, Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Italy) Multivariate Permutation Test to Compare Survival Curves for Matched Data

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11:00 Contributed 3 : Missing Data and Imputation #401 Chair : G. Frank Liu(Merck Research Laboratories, USA) + #402 11:00 C-3-1 : Kyoji Furukawa(Department of Statistics, Radiation Effects Research Foundation, Japan) Multiple Imputation for Incomplete Time-Dependent Covariates in Survival Analyses 11:17 C-3-2 : Michikazu Nakai(National Cerebral and Cardiovascular Center, Japan) Comparison of Imputation Methods for Missing Values in AR(1) Longitudinal Studies 11:34 C-3-4 : Yuichiro Kaneko(Biostatistics Group, Data Science, Development, Astellas Pharma Inc., Japan) Evaluation of the Performance of MAR-Assumed Methods in a Presence of Non-Ignorable Missing Data in Longitudinal Study 11:51 C-3-5 : Annie Green Howard(University of North Carolina at Chapel Hill, USA) Missing Data in Non-Parametric Tests of Correlated Data with One Covariate of Interest 12:08 C-3-6 : G. Frank Liu(Merck Research Laboratories, North Wales, USA) Tackling Missing and Left-Truncated Data in Longitudinal Clinical Trials

11:00 Contributed 4 : Distribution and Statistical Inference #503 Chair : Etsuo Miyaoka(Tokyo University of Science, Japan) + #504 11:00 C-4-1 : Lakhana Watthanacheewakul(Faculty of Science, Maejo University, Thailand) Transformations with Right Skew Data 11:17 C-4-3 : Masayuki Jimichi(Kwansei Gakuin University, School of Business Administration, Japan) Exact Moments of Feasible Generalized Ridge Regression Estimator for Linear Basis Function Models 11:34 C-4-4 : Yi-Hui Zhou(Biostatistics Department, University of North Carolina, USA) A New Resampling Procedure to Correct for Ranking Bias 11:51 C-4-5 : Signe Marie Jensen(Department of Human Nutrition(LIFE) University of Copenhagen, Denmark) Improved Standard Errors for Model Average Estimates 12:08 C-4-6 : David Todem(Department of Epidemiology and Biostatistics, Michigan State University, USA) Score Tests for Detecting Varying Heterogeneity against Homogeneity in Parametric Models

27 August (Monday): 14:00-15:45 14:00 Invited Session 2 : The Landmark Approach to Event History Analysis International Organiser : Hans C. van Houwelingen(Leiden University Medical Center, The Netherlands) conference Chair : Hans C. van Houwelingen room 14:00 I-2-1 : Hein Putter(Leiden University Medical Center, The Netherlands) The Landmark Approach and How to Implement it 14:25 I-2-2 : Layla Parast(Harvard School of Public Health, USA) Landmark Prediction of Long Term Survival Incorporating Short Term Event Time Information 14:50 I-2-3 :Per Kragh Andersen(University of Copenhagen, Denmark) Competing Risk and Time-Dependent Covariates 15:15 I-2-4 : Jon Michael Gran(University of Oslo, Norway) Causal Modeling Through Sequential Cox Models 15:40 General Discussion and Questions

14:00 Invited Session 3 : Statistical Challenges in the Analysis of Rare Genetic Variants in Association #501 Studies Organisers : Taesung Park(Seoul National University, South Korea), Gang Zheng(National Heart, Lung and Blood Institute/NIH, USA) Chair : Taesung Park 14:00 I-3-1 : Suzanne Leal(Baylor College of Medicine, USA) Association Analysis of Complex Trait Rare Variant Data: From Next Generation Sequencing to Exome Chips 14:25 I-3-2 : Andreas Ziegler(Universität zu Lübeck, Germany) The Joint Analysis of Rare and Frequent Sequence Variants in Case-Control Studies Using Smoothed Areas 14:50 I-3-3 : Sungho Won(Chung-Ang University, Korea) On Rare-Variant Analysis in Population-Based Designs: Using All Available Information to Maximize the Power 15:15 Discussant : Ryo Yamada(Kyoto University Graduate School of Medicine, Japan) 15:40 General Discussion and Questions

22 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

27 August (Monday): 14:00-15:45 (cont.) 14:00 Contributed 5 : Nested Case-Control Study #502 Chair : Shizue Izumi(Oita University, Japan) 14:00 C-5-1 : Shizue Izumi(Department of Computer Science and Intelligent Systems, Oita University, Japan) Design and Method of the Power Calculations for Likelihood Ratio Tests in the Nested Case-Control Studies 14:17 C-5-3 : Agus Salim(National University of Singapore, Singapore) A Semiparametric Approach to Secondary Analysis of Nested Case-Control Data 14:34 C-5-4 : Ruth H. Keogh(MRC Biostatistics Unit, UK) Using Full Cohort Data in Nested Case-Control and Case-Cohort Studies by Multiple Imputation 14:51 C-5-5 : Jennifer Wilcock(University of Auckland, New Zealand) Complex Case-Control Studies: Efﬁ ciency of the Proﬁ le Likelihood Estimator

14:00 Contributed 6 : Pharmacokinetic and Pharmacodynamic Studies #401 Chair : Masako Nishikawa(National Institute of Public Health, Japan) + #402 14:00 C-6-1 : Leena Choi(Department of Biostatistics, School of Medicine, Vanderbilt University, USA) A Bayesian Hierarchical Nonlinear Mixture Model in the Presence of Artifactual Outliers in a Population Pharmacokinetic and Pharmacodynamic Study 14:17 C-6-2 : Chi-Hsuan Huang(Institute of Statistics, National Central University, Taiwan) Semi-Parametric Modelling for Pharmacokinetic Data 14:34 C-6-3 : Wen-Ming Lin (Institute of Statistics, National Central University, Taiwan) Detecting Outlying Proﬁ les for Pharmacokinetic Data 14:51 C-6-5 : Masanobu Hayakawa(Graduate School of Medicine, Kurume University, Japan) Estimating Distance Between Characteristics of Generic Drugs and Brand Name Drug

14:00 Contributed 7 : Sampling Method #503 Chair : Stephan Morgenthaler(Ecole Polytechnique Fdrale de Lausanne, Switzerland) + #504 14:00 C-7-1 : O. M. Olayiwola(Department of Statistics, Federal University of Agriculture, Nigeria) On Patterns of Response and Non-Response in a Longitudinal Survey of OYO Community, OYO State, Nigeria 14:17 C-7-2 : Jane L. Hutton(Department of Statistics, University of Warwick, UK) A Uniﬁ ed Approach to Multilevel Sample Selection Models 14:34 C-7-3 : Emmanuel O. Ogundimu(Department of Statistics, University of Warwick, UK) A General Sample Selection Model with Underlying Skew-Normal Distribution 14:51 C-7-4 : Albert Wong(National Institute for Public Health and the Environment, The Netherlands) Modeling the Distribution of Lifetime Health Care Expenditures: A Nearest Neighbor Resampling Approach

27 August (Monday): 14:00-18:00 14:00 Poster Presentation 1 Reception Hall P-1-1 Melissa Pisaroglo de Carvalho(Programa de Pós Graduação em Genética e Melhoramento,Departamento de Estatistica, Universidade Federal de Viçosa, Brazil) Comparison of Among and Within Sugarcane Family Selection Methods under Different Genetic Scenarios P-1-2 Thomas Idemudia Aneni(Department of Animal and Environmental Biology, University of Benin, Nigeria) Empirical Assessment of Climate Change Impacts on the Leaf Miner, a Major Pest of the Oil Palm in Nifor, Nigeria P-1-3 Mariana Ragassi Urbano(Departamento de Ciências Exatas, ESALQ/USP, Brazil) Dose Response Models with Natural Mortality and Random Effects P-1-4 Yuri García Saavedra(Department of Mathematical Sciences, University of Puerto Rico Mayagüez, Puerto Rico) Using Nonlinear Mixed Models with Beta Distribution to Fit Disease Progress Curves to Model Black Sigatoka Epidemics in Banana in Puerto Rico P-1-5 Patricia Pinamang Acheampong(CSIR-Crops Research Institute, Ghana) The Behaviour and Attitudes of Vegetable Consumers in Ghana: A Case Study of the Cities of Kumasi and Cape Coast P-1-6 Monthon Lertworapreecha(Department of Biology, Faculty of Science, Thaksin University, Thailand) Antimicrobial Resistance and Occurrence of Resistant Genes in Salmonella Isolated from Animal Sources P-1-7 M. K. Osei(CSIR-Crops Research Institute, Ghana) Phenotypic and Molecular Screening of Some Tomato Germplasm for Resistance to Tomato Yellow Leaf Curl Virus (TYLCV) Disease in Ghana

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P-1-8 E. Ouma(Moi University, Kenya) Development of Maize Single Cross Hybrids for Tolerance to Aluminium Toxicity P-1-9 Lakmini K. Herath(Department of Agribusiness Management, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Sri Lanka) Application of Stochastic Volatility Models for Prices in Sri Lankan Rubber Market with Solutions for Issues in Model Specifi cation P-1-10 Ronald Dodge(West Point, National Defense University, USA) Active Authentication: Cognitive Fingerprints for Passwords P-1-11 Yasuo Sugitani(Clinical Research Planning Department, Chugai Pharmaceutical Co., Ltd., Japan) Biomarker-Based Bayesian Randomized Phase II Clinical Trial Design to Select a Sensitive Patient Subpopulation P-1-12 Dilip C. Nath(Department of Statistics, Gauhati University, India) A Bayesian Approach in Joint Longitudinal Data Modeling: An Application in Type 2 Diabetes Drug Effect Comparison P-1-13 Yasuyuki Kakurai(Department of Management Science, Tokyo University of Science, Japan) Impact of Vague Prior Distributions in the Continual Reassessment Method P-1-14 Himel Mallick(Department of Biostatistics, University of Alabama, UK) A New Bayesian Lasso P-1-15 Kandala Ngianga-Bakwin(Warwick Medical School, The University of Warwick, UK) The Geography of HIV/AIDS Infection in Botswana P-1-16 Manir Hossain Mollah(Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan) Improved Power of Detection of Regulation Hotspots by ß-empirical Bayes Approach P-1-17 Maroussia Slavtchova-Bojkova(Department of Probability, Operational Research and Statistics, Faculty of Mathematics and Informatics, Sofi a University, Bulgaria) On Bayesian Estimations of the Offspring Mean in Branching Processes with Application to Outbreaks of Infectious Disease P-1-18 Yohei Kawasaki(Tokyo University of Science, Japan) A Bayesian Inference of Two Poisson Parameters P-1-19 Lina D. Thomas(IME-USP, Des-UFSCar, Brazil) Building Complex Networks Throught Classical and Bayesian Statistics - a Comparisson P-1-20 T. Ogura(Chuo University, Japan) Flexible and Powerful Exact Test for Hypotheses of Two Proportions in the Era of Clinical Trial Registration P-1-21 Manoel Vitor Veloso(Universidade Federal de Lavras, Brazil) Stochastic Search Variable Selection(SSVS) in the Three Parameter Item Response Theory(IRT) Models: A Case Study in Cytology P-1-22 Natalie Blades(Department of Statistics, Brigham Young University, USA) Consensus Ranking of Disease Severity P-1-24 Tomohiro Shinozaki(Department of Biostatistics, School of Public Health, The University of Tokyo, Japan) Estimating Causal Effects of Atorvastatin in Elderly Diabetics P-1-25 Yasutaka Chiba(Division of Biostatistics, Clinical Research Center, Kinki University School of Medicine, Japan) The Large Sample Bounds on the Principal Strata Effect with Application to a Prostate Cancer Prevention Trial P-1-26 Yukari Uemura(University of Tokyo, Japan) IPW Log-Rank Test for Two Defi ned Dynamic Treatment Regimes P-1-27 Masayuki Henmi(Department of Data Science, The Institute of Statistical Mathematics, Japan) Covariate Adjustment in Clinical Trials via Estimated Propensity Scores P-1-28 Haruka Yamashita(Graduate School of Science and Technology, Seikei University, Japan) Infl uence of Random Non-Compliance to Performance of Estimation for a Causal Effect Under Non-Compliance P-1-29 Takanobu Nomura(Graduate School of Medicine, Kurume University, Japan) Estimation of the Average Causal Effect Via Multiple Propensity Score Stratifi cation

P-1-30 Ilija Barukčić(Horandstrasse, Germany) The Deterministic Relationship Between Cause and Effect P-1-31 Takeshi Nishiyama(Clinical Trial Management Center, Nagoya City University Hospital, Japan) A Scan Statistic to Detect Disease Gene Clusters from Rare CNV Data

24 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

27 August (Monday): 16:15-18:00 16:15 Biometrics Showcase Session : Meritorious Papers in Biometrics by an IBS Member for 2010-11 International Chair : Marie Davidian (North Carolina State University, USA) conference room 16:15 Wei Pan(Division of Biostatistics, University of Minnesota, USA) Incorporating Predictor Network in Penalized Regression with Application to Microarray Data 17:05 Anastasios A. Tsiatis(Department of Statistics, North Carolina State University, USA) A Robust Method for Estimating Optimal Treatment Regimes 17:55 General Discussion and Questions

16:15 Contributed 8 : Cancer Clinical Trial #501 Chair : William E. Barlow(Cancer Research and Biostatistics, USA) 16:15 C-8-1 : Michael Sweeting(MRC Biostatistics Unit, UK) Escalation Strategies for Combination Therapy Phase I Trials 16:32 C-8-2 : Xavier Paoletti(Institut Curie, Service biostatistique, France) Phase I Dose Finding Methods Using Longitudinal Data and Proportional Odds Model in Oncology 16:49 C-8-3 : Akihiro Hirakawa(Department of Management Science, Tokyo University of Science, Japan) A Dose-Finding Approach Based on Shrunken Predictive Probability for Combinations of Two Agents in Phase I Trials 17:06 C-8-5 : Shigeyuki Toyoizumi(Pﬁ zer Japan Inc., Japan) Optimal Two-Stage Designs Incorporating Response and Early Progression 17:23 C-8-6 : Hideharu Yamamoto(Clinical Research Planning Department, Chugai Pharmaceutical Co., Ltd., Japan) A Hybrid Seamless Phase II/III Study Design to Develop a Molecular Targeted Drug in Cancer Patients with Poor Prognosis

16:15 Contributed 9 : Longitudinal Data : Modeling #502 Chair : Satoshi Hattori(Kurume University, Japan) 16:15 C-9-1 : Toshihiro Misumi(Biostatistics Group, Data Science, Development, Astellas Pharma Inc., Japan) Time-Varying Coefﬁ cient Model for Longitudinal Data in Clinical Trial

16:32 C-9-2 : Daniel Gerhard(Institute of Biostatistics, Leibniz Universität Hannover, Germany) Selecting Models in Longitudinal Data Analysis by the Generalized Order-Restricted Information Criterion

16:49 C-9-3 : Brian D. M. Tom(MRC Biostatistics Unit, UK) Impact of Approximating Time-Varying Explanatory Variables as Piecewise Constant Functions in the Multi-State Modelling of Intermittent Observations

17:06 C-9-4 : Ryoji Nakamura(Inter Scientiﬁ c Research Co.,Ltd., Japan) A Mixture Model Combined with Proportional Odds Model for Longitudinal Measurement Data in Randomdized Controlled Trials

17:23 C-9-5 : Sara Viviani(Department of Statistics, Sapienza University of Rome, Italy) Joint Modeling for Discrete Longitudinal Responses and Time to Drop-out

17:40 C-9-6 : Dietrich von Rosen(Swedish University of Agricultural Sciences & Stockholm University , Sweden) General Multivariate Linear Models and Reduced Rank Regression

16:15 Contributed 10 : Analysis of Ecological Data (1) #401 Chair : Nobuhiro Minaka(National Institute for Agro-Environmental Sciences, Japan) + #402 16:15 C-10-1 : Nobuhiro Minaka(Ecosystem Informatics Division, National Institute for Agro-Environmental Sciences, Japan) The Gromov Transform of Phylogenetic Diversity Index and Its Statistical Conﬁ dence Test 16:32 C-10-2 : A. H. Welsh(The Australian National University, Australia) Analysing Occupancy Surveys 16:49 C-10-5 : Hiroshi Okamura(National Research Institute of Far Seas Fisheries, Fisheries Research Agency, Japan) Estimating Population Size of Long-Diving Animals Combining Line Transect Sampling Data with Biotelemetry Data 17:06 C-10-6 : Rachel McCrea(National Centre for Statistical Ecology, University of Kent, UK) Score Tests in Capture-Recapture

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16:15 Contributed 11 : Categorical Data #503 Chair : Takemi Yanagimoto(Chuo University, Japan) + #504 16:15 C-11-1 : Kuo-Chin Lin(Department of Business Administration, Tainan University of Technology, Taiwan) Goodness-of-Fit Tests for Cumulative Logit Models Based on Global Odds Ratio 16:32 C-11-2 : Victor Vera(School of Mathematics and Statistics, University of Sydney, Australia) Comparison of Two Tests for Marginal Symmetry in Phylogenetic Analysis 16:49 C-11-3 : Kazushi Maruo(Clinical Data Science Department, Pharmaceutical Division, Kowa Company, Ltd., Japan) A New Method Constructing Conﬁ dence Intervals for the Diference of Two Binominal Proportions

17:06 C-11-4 : Satoshi Kajimoto(Unit of Statistical Genetics, CGM, Med, Kyoto University, Japan) An Orthogonal Matrix, Which Is Useful to Interpret the Restriction of Marginal Counts of Multi-Way Tables 17:23 C-11-5 : Yi-Ju Chen(Department of Statistics, Tamkang University, Taiwan) Imputation Strategies for Incomplete Longitudinal Binary Data 17:40 C-11-6 : Imen Hammami(Laboratory of Applied Mathematics, Paris Descartes University, France) Evidence for Overdispersion in the Distribution of Malaria Parasite Density in Thick Films

28 August (Tuesday): 08:45-10:30 08:45 Invited Session 4 : Advances in Spatial Latent Variable Modeling with Applications to International Bio-Sciences conference Organiser : Dipankar Bandyopadhyay (Medical University of South Carolina, USA) room Chair : Saonli Basu(University of Minnesota, USA) 08:45 I-4-1 : Andrew Lawson(Medical University of South Carolina, USA) Prior Choice for Latent Grouping in Covariate Modulated Survival and Space-Time Mixture Models 09:10 I-4-2 : Yeonseung Chung(Korea Advanced Institute of Science and Technology, South Korea) Bayesian Spatially-Varying Coefﬁ cient Models for Estimating the Toxicity of the Chemical Components of Fine Particulate Matter 09:35 I-4-3 : Sudipto Banerjee(University of Minnesota, USA) Flexible Latent Factor Modeling for Large Misalingned Spatial Data 10:00 I-4-4: Rasmus Waagepetersen(Aalborg University, Denmark) Optimal Estimation of the Intensity of a Spatial Cox Process 10:25 General Discussion and Questions

08:45 Contributed 12 : Clinical Trials: Design Issues (1) #501 Chair : Maria Grazia Valsecchi(University of Milano Bicocca, Italy) 08:45 C-12-1 : Koko Asakura(Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Japan) Sample Size Determination in Group Sequential Trials with Two Co-Primary Endpoints 09:02 C-12-2 : Nobushige Matsuoka(Clinical Statistics, Pﬁ zer Japan Inc., Japan) Sample Size Determination for Longitudinal Trials 09:19 C-12-3 : Pierre L. Lafaye de Micheaux(Département de Mathématiques et Statistique, Université de Montréal, Canada) Power and Sample Size Determination in Clinical Trials with Multiple Primary Continuous Endpoints 09:36 C-12-4 : Daniel Wachtlin(Interdisciplinary Center for Clinical Trials, Germany) Sample Size Recalculation in Longitudinal Clinical Trials Using Generalized Estimating Equations(GEE) 09:53 C-12-5 : Mari Saito(Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Japan) Comparison of Analysis Methods of Cluster Randomized Trial Data with Binary Outcome

26 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

28 August (Tuesday): 08:45-10:30 (cont.) 08:45 Contributed 13 : Analysis of Genetic Data (1): GWAS #502 Chair : Masaaki Matsuura(The Japanese Foundation for Cancer Research, Japan) 08:45 C-13-1 : Mizanur R. Khondoker(Department of Biostatistics, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health and Maudsley NHS Foundation Trust, King's College London, UK) Linking Genetics of Brain Changes to Alzheimer's Disease: A Whole Genome Association Scan of High Resolution Regional MRI Volume and Thickness Measures 09:02 C-13-2 : Susana Eyheramendy (Pontiﬁ cia Universidad Catolica de Chile, Chile) Model-Based Tool to Identify Clusters of Relevant SNPs for Multiple Related Phenotypes 09:19 C-13-3 : Alexandra Gillett(School of Mathematics and Statistics, University of New South Wales, Australia) Creating Disease Informative Similarity Matrices in Case-Control Genome-Wide Association Studies 09:36 C-13-4 : Vittorio Perduca(Applied Mathematics Laboratory, Paris Descartes University, France) Power Analysis of Genome Wide Association Studies Based on Simulations of Phenotypes 09:53 C-13-5 : Florian Frommlet(Department of Medical Statistics, Medical University Vienna, Austria) Genetic Association Using a Memetic Algorithm with Modiﬁ cations of BIC as Fitness Function 10:10 C-13-6 : Jaehoon Lee(Department of Statistics, Seoul National University, South Korea) Gene Set Analysis for Rare Variant

08:45 Contributed 14 : Agriculture Research (1) #401 Chair : Hirohisa Kishino(The University of Tokyo, Japan) + #402 08:45 C-14-1 : David A. Elston(Biomathematics and Statistics Scotland, UK) Stratiﬁ cation of Climate Projections for Efﬁ cient Model-Based Assessment of Uncertainty and Variation in Climate Impact Projections 09:02 C-14-2 : Christian Ritz(Department of Basic Sciences and Environment(LIFE), University of Copenhagen, Denmark) Analysis of Germination Curves 09:19 C-14-3 : Daniela Cunha da Sé(Department of Forest Science, Federal University of Lavras, Brazil) Analysis of Variance of an Experiment of Candeia(Eremanthus Erythropappus) Considering Spatial Pattern 09:36 C-14-4 : H. I. Mbachu (Imo State Polytecnic Umuagwo Owerri Imo State, Nigeria) Contributions of Agro-Statistics Research in Nigeria's Agricultural Development Programme. 09:53 C-14-5 : Okoye M.N.(Plant Breeding Division, Nigerian Institute for Oil Palm Research, Nigeria) Multivariate Analysis of Genetic Divergence in Twenty Four Genotypes of Oil Palm(Elaeis guineensis Jacq.) 10:10 C-14-6 : Lynette A. Hunt(Department of Statistics, University of Waikato, New Zealand) Mixture Model Selection for Three-Mode Three-Way Data

08:45 Contributed 15 : Multiple Testing #503 Chair : Manabu Iwasaki(Seikei University, Japan) + #504 08:45 C-15-1 : Christian Ljørring(R&D, ALK-ABELLO, Denmark) Why Fisher's least Signiﬁ cant Difference Procedure Can Be Appropriate as the Multiple Test Strategy in a 3-Armed Conﬁ rmatory Clinical Trial 09:02 C-15-4 : Djalel Meskaldji(Ecole Polytechnique Fédérale de Lausanne, Switzerland) Optimal Multiple Tests 09:19 C-15-5 : Alessio Farcomeni(University of Hawaii, USA) Effect-Size Enhancing Multiple Testing Procedures Controlling Functionals of the False Discovery Proportion 09:36 C-15-6 : Yoshiyuki Ninomiya(Institute of Mathematics for Industry, Kyushu University, Japan) A P-Value Evaluation for Multiple Testing Problem Based on Highly Correlated Test Statistics 09:53 C-15-7 : Ron Wehrens(Biostatistics and Data Management, Fondazione Edmund Mach, Italy) Stability Selection for Omics Data

27 XXVIth International Biometric Conference

28 August (Tuesday): 08:45-12:45 08:45 Poster Presentation 2 Reception Hall P-2-1 Chris-Fook-Sheng Ng(Environmental Epidemiology Section, Center for Environmental Health Sciences, National Institute for Environmental Studies, Japan) Predicting Heat-Related Premature Mortality in the Kanto Region of Japan P-2-2 Raúl E. Macchiavelli(University of Puerto Rico Mayagüez, Department of Crops and Agroenvironmental Sciences, Puerto Rico) Statistical Properties of Water Quality Criteria for Lakes in Puerto Rico P-2-3 Myungjoo Kye(Graduate School of Public Health, Seoul National University, South Korea) The Effect of Temperature Change between Neighbouring Days on Mortality P-2-4 Gabriella Drégelyi-Kiss(University of Pécs, Pollack Mihály Faculty of Engineering and Information Technology, Department of Environmental Engineering, Hungary) Effects of Different Climates on Biodiversity P-2-5 Gen Sakurai(National Institute for Agro-Environmental Sciences, Japan) Correcting CO2 Fertilization Effect on Crop Growth Using Field Observation Data by Bayesian Method P-2-6 W. B. Yahya(Department of Statistics, University of Ilorin, Nigeria) Risk Perception of HIV/AIDS Among Nigerian Youths P-2-7 M. Pandey(Biostatistics(Retd.), Department of Zoology, Department of Computer Sc.Faculty of Science BHU, India) Effect of Noise Pollution in Varanasi City on Physical and Mental Health P-2-8 Takahiro Hayakawa(Department of Biostatistics, Kyoto University School of Public Health, Japan) Improving the Efﬁ ciency of Odds Ratio Estimation in Case-Cohort Studies by Using External Case Information P-2-9 Youngeun Yi(Graduate School of Public Health Seoul National University, South Korea) Comparison of Models Combined Temperature and Humidity Variables in Temperature-Mortality Study P-2-10 Hisashi Noma(Department of Biostatistics, Kyoto University School of Public Health, Japan) Multiple Imputation Analysis for Two-Stage Case Control Studies P-2-11 Ayano Takeuchi(Department of Biostatistics, School of Public Health, The University of Tokyo, Japan) Regional Differences in Acute Health Effects of Air Pollution Using Fractional Polynomial Model P-2-12 Tomoyuki Akita(Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical Sciences, Hiroshima University, Japan) Etiological-Based Mathematical Model for Hepatocellular Carcinoma Mortality P-2-13 Birgitt Wiese(Hannover Medical School, Institute of Biometrics Germany, Germany) Measuring Data Quality in Clinical Research P-2-14 Hiroko Shimoda(Graduate School of Medicine, Kyoto University, Japan) Stress, Physical Factors and Super Cognitive Arousal Relating Circadian Rhythm: As Promoting and Inhibiting Factors after Disaster P-2-15 Hyung-yun Choi(Department of Biostatistics, Graduate School of Public Health, Seoul National University, South Korea) Effects on Health by Cold Spell in Major Six Cities in Korea: Comparison Between the 1990s and 2000s P-2-16 Shuichi Midorikawa(Tokyo University of Science, Japan) Application of the Hidden Markov Model to the Cancer Mortality Data in Japan P-2-17 Keiko Otani(Department of Environmetrics and Biometrics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan) Health Anxieties in Atomic-Bomb Survivors in Hiroshima and Nagasaki Six Decades after the Explosions P-2-18 Vicente A. Núñez-Antón(Department of Econometrics and Statistics and Department of Applied Mathematics, Statistics and Operations ResearchUniversity of the Basque Country UPV/EHU, Spain) Partial Additive Beta-Binomial Model for Bounded Outcome Scores P-2-19 Edmore Marinda(School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, South Africa) Modeling the Bed Capture Enzyme Immunoassay(CIEA) in New HIV Infections P-2-20 Maria Lucia Sundefeld (Biostatistics at School of Dentistry of Araçatuba, UNESP-São Paulo State University, Brazil) A Scale of Items to Evaluate the Level of Mouth Cancer Awareness Using IRT

P-2-22 Crysttian Arantes Paixão(Applied Mathematics School, Getulio Vargas Foundation, Brazil) Forecast of Speed of Propagation of Dengue Epidemic P-2-23 Junji Matsuba(Graduate School of Biomedical Sciences, Hiroshima University, Japan) An Age-Shift Failure Time Model for Analyzing Dose-Response Relationship and Its Application to Analyses of Atomic Bomb Survivors' Cohort Data P-2-24 Munechika Misumi(Department of Statistics, Radiation Effects Research Foundation, Japan) Radiation Dose-Response of Skin Cancer Risk in the Radiation Effects Research Foundation Life Span Study Cohort P-2-25 Koichi Shirakawa(Department of Pathogenic Microbiology,Graduate School of Medicine, Kyoto University, Japan) Analysis of Malaria Data from Sarawak, Malaysis: Caution on Use of Anti-Maralial Drug for Mixed Infection and Infectious Control of Super Infection of Maralia in Particular

28 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

P-2-26 James W. Rudge(Communicable Diseases Policy Research Group, London School of Hygiene and Tropical Medicine, Thailand) A Mathematical Model for Evaluating Strategies to Improve Pandemic Inﬂ uenza Preparedness in Cambodia P-2-27 Kezia R. Badhiti(Computer Science, Adikavi Nannaya University, India) India's Vision ---Polio Free Generation P-2-28 Laaksonen M. A.(National Institute for Health and Welfare, Finland) New Software for Calculation of Population Attributable Fraction(PAF) in a Cohort Study Design P-2-29 Shigeru Kumazawa(Former, Japan Nuclear Energy Safety Organisation, Japan) Hybrid Lognormality of Various Radiological Data P-2-30 Sergio Arciniegas-Alarcón(Departamento de Ciências Exatas, Universidade de São Paulo/ESALQ, Brazil) Data Imputation in Trials with Genotype×Environment Interaction

28 August (Tuesday): 11:00-12:45 11:00 Invited Session 5 : New Developments in Statistical Ecology International Organiser : Byron J. T. Morgan(University of Kent, UK) conference Chair : Byron J. T. Morgan room 11:00 I-5-1 : Simon Bonner(University of Kentucky, USA) Mark-Recapture of Whalesharks with Multiple, Natural Marks

11:25 I-5-2 : Janine Illian(University of St Andrews, Scotland) Complex Spatial and Spatio-Temporal Point Process Modeling with Applications in Ecology

11:50 I-5-3 : Martin Ridout(University of Kent, UK) Effect of Early-Life Covariates on Meerkat Longevity

12:15 Discussant : Rachel Fewster(University of Auckland, New Zealand) 12:40 General Discussion and Questions

11:00 Contributed 16 : Clinical Trials: Design Issues (2) #501 Chair : Stefan Michiels(Institut Jules Bordet, Belgium) 11:00 C-16-1 : Wai Y. Yeung(School of Mathematical Sciences, Queen Mary, University of London, UK) Imbalance Properties of Centre-Stratiﬁ ed Permuted Block Randomization and Complete Randomization for Several Treatments in a Clinical Trial 11:17 C-16-2 : Hiroyuki Uesaka(Osaka University, Japan) Comparisons of Three Stage Adaptive Designs for a Clinical Trial 11:34 C-16-4 : Takemi Yanagimoto(Chuo University, Japan) Designing an Additional Trial After a Non-Signiﬁ cant Result: A Bayesian Predictor-Based Procedure 11:51 C-16-5 : Hans Hockey(Biometrics Matters Ltd, New Zealand) Some Observations on the Design of Early Stage Clinical Trials in the Pharmaceutical Industry 12:08 C-16-6 : Kentaro Kuroishi(Astellas Pharma Inc., Japan) Evaluating Impact on Application of Bayesian Inference to the Hierarchical Generalized Linear Models in Clinical Trial Design

11:00 Contributed 17 : Analysis of Genetic Data (2) #502 Chair : Andreas Ziegler(Universität zu Lübeck, Germany) 11:00 C-17-1 : Wesley K. Thompson(Department of Psychiatry, University of California, USA) Bayesian Models for Improving Power in Genome-Wide Association Studies 11:17 C-17-2 : Saurabh Ghosh(Indian Statistical Institute, India) A Computationally Fast Bayesian Semi-Parametric Algorithm for Inferring Population Structure and Adjusting for Case-Control Association Tests 11:34 C-17-3 : Marina Evangelou(Medical Research Council Biostatistics Unit, UK) Bayesian Hierarchical Modeling of SNPs and Pathways for Identifying Pathways Associated with Complex Traits and for Predicting Unobserved Traits 11:51 C-17-4 : Saonli Basu(Division of Biostatistics, University of Minnesota, USA) A Bayesian Partitioning Model for Detection of Multilocus Interaction in Case-Control Studies 12:08 C-17-5 : Pavel Goldstein(University of Haifa, Israel) High Throughput Genome-Wide Scan for Epistasis with Implementation to Recombinant Inbred Lines(RIL) Populations 12:25 C-17-6 : Tomasz Burzykowski(I-BioStat, Hasselt University, Belgium) High Resolution QTL Mapping with Whole-Genome Sequencing Data

29 XXVIth International Biometric Conference

11:00 Contributed 18 : Agriculture Research (2) #401 Chair : Tetsuhisa Miwa(National Institute for Agro-Environmental Sciences, Japan) + #402 11:00 C-18-1 : Emilio A. Carbonell(Biometric Unit, IVIA, Spain) The Effect of Epistasis in QTL Detection 11:17 C-18-2 : Gerrit Gort(Biometris, Wageningen University and Research Center, The Netherlands) SNP Genotype Calling in Tetraploid Potato: A Normal Mixture Approach, Available in the R-Package Fittetra 11:34 C-18-3 : O. M. Olayiwola(Statistics Department, Federal University of Agriculture, Nigeria) Application of Factorial Design and Response Surface Methodology on Growth Rate of Broiler Chickens Served with Fluted Pumpkin Leaves Extract 11:51 C-18-4 : Frederick J. Calitz(Biometry Unit, Agricultural Research Council, South Africa) Misconception of Statistical Experimental Replication in a Completely Randomised Design 12:08 C-18-5 : Emlyn R. Williams(Statistical Consulting Unit, The Australian National University, Australia) Construction of Efﬁ cient P-Rep Designs for Use in Early Generation Field Trials 12:25 C-18-6 : Imran Khan(Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, India) Construction and Analysis of Partial Diallel Crosses Based on PBIB Designs with Five Associate Classes

11:00 Contributed 19 : Classifi cation and Mixture Distribution #503 Chair : Jane L. Hutton(University of Warwick, UK) + #504 11:00 C-19-1 : Avner Bar-Hen(Université Paris Descartes, France) Infl uence Measures for Cart Classifi cation Trees 11:17 C-19-2 : Aidan G. O'Keeffe(MRC Biostatistics Unit, UK) Mixure Distributions in Clustered Multi-State Models for Longitudinal Data: Identifying Sub-Populations of 'Movers' and 'Stayers' 11:34 C-19-3 : Osamu Komori(The Institute of Statistical Mathematics, Japan) Maximization of a Generalized T-Statistic for Two-Class Discrimination Problem 11:51 C-19-4 : Oludare Samuel Ariyo(National Horticultural Research Institute, Nigeria) Effect of Cost Ratios to Classical Classifi cation Functions Performance

28 August (Tuesday): 14:00-15:45 14:00 Invited Session 6 : Approximate Bayesian Computation (ABC) and Likelihood-Free Inference International Organiser : Tony Pettitt(Queensland University of Technology, Australia) conference Chair : Daniel Wegmann(University of California, USA) room 14:00 I-6-1 : Tony Pettitt(Queensland University of Technology, Australia) Approximate Bayesian Computation for Time Evolving Models 14:30 I-6-2 : Mark Beaumont(University of Bristol, UK) Approximate Bayesian Computation in Population Genetics 15:00 I-6-3 : Daniel Wegmann(University of California, USA) Efﬁ cient Postsampling Approaches for Approximate Bayesian Computation 15:30 General Discussion and Questions

14:00 Invited Session 7 : Novel Mixture Modelling and Likelihood Methods in Modern Biomedical #501 Applications Organiser : Shili Lin(The Ohio State University, USA) Chair : Shili Lin 14:00 I-7-1 : Geoff McLachlan(University of Queensland, Australia) Mixtures of Skew Distributions for an Automated Approach to the Analysis of Flow Cytometric Data 14:25 I-7-2 : Abbas Khalili(McGill University, Canada) Regularization in Finite Mixture of Regression Models for Diverging Number of Parameters with Application to Telemonitoring of Parkinson's Disease Progression 14:50 I-7-3 : Zewei Luo(Fudan University, China) A Robust and Efﬁ cient Statistical Method for Genetic Association Studies Using Case and Control Samples from Multiple Cohorts with Application to Parkinson's Disease 15:15 Discussant : Jian Qing Shi(Newcastle University, UK) 15:40 General Discussion and Questions

30 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

28 August (Tuesday): 14:00-15:45 (cont.) 14:00 Contributed 20 : Analysis of Genetic Data (3) #502 Chair : Shigeyuki Matsui(The Institute of Statistical Mathematics, Japan) 14:00 C-20-1 : Thorsten Dickhaus(Department of Mathematics, Humboldt-University Berlin, Germany) The Allele Distribution in Next-Generation Sequencing Data Sets is Accurately Described as the Result of a Stochastic Branching Process 14:17 C-20-2 : John Hinde(National University of Ireland, Ireland) Finite Mixture Model Clustering of SNP Data 14:34 C-20-5 : Elizabeth Thompson(Department of Statistics, University of Washington, USA) Multiple Identity by Descent in Population-Based Genetic Mapping 14:51 C-20-6 : Maiko Narahara(Unit of Statistical Genetics, Center for Genomic Medicine, Kyoto University, Japan) DNA-Based Identiﬁ cations in Mass Fatality Incidents Based on Probabilities Conditional on an Entire Dataset

14:00 Contributed 21 : Causal Inference (1) #401 Chair : Anastasios A. Tsiatis(North Carolina State University, USA) + #402 14:00 C-21-1 : Ying Huang(Fred Hutchinson Cancer Research Center, USA) Design and Estimation for Principal Surrogate Markers in Vaccine Trials 14:17 C-21-2 : Masataka Taguri(Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Japan) A Principal Stratifi cation Approach for Evaluating Natural Direct and Indirect Effects in the Presence of Intermediate Confounding 14:34 C-21-3 : Theis Lange(Department of Biostatistics, University of Copenhagen, Denmark) A Simple Unifi ed Approach for Estimating Natural Direct and Indirect Effects 14:51 C-21-5 : Satoshi Hattori(Biostatistics Center, Kurume University The Institute of Statistical Mathematics , Japan) Stratifi ed Doubly Robust Estimators for an Average Causal Effect

14:00 Contributed 22 : Analysis of Ecological Data (2) #503 Chair : Simon N. Wood(University of Bath, UK) + #504 14:00 C-22-2 : Cleridy E. Lennert-Cody(Inter-American Tropical Tuna Commission, USA) A Multivariate Regression Tree Approach for Deﬁ ning Population Spatial Units: Simultaneous Analysis of Frequency Distributions of Morphological Characteristics and Time Series Data 14:17 C-22-3 : Hitoshi Koyano(Institute for Chemical Research, Kyoto University, Japan) New Method of Fractional Parentage Analysis and Its Application to a Wild Population of Trout 14:34 C-22-4 : Russell B. Millar(Department of Statistics, University of Auckland, New Zealand) Estimating the Number of Salmon Returning to Spawn 14:51 C-22-5 : Mayumi Naka(Keio University, Japan) Inﬂ uence of Environmental Factors to the Growth of Banana Prawn in Australian Sub-Tropical Estuaries

28 August (Tuesday): 14:00-18:00 14:00 Poster Presentation 3 Reception Hall P-3-2 Eisuke Hida(Center for Medical Statistics, Japan) Three-Arm Non-Inferiority Trials with a Prespecifi ed Margin for Time-to-Event Endpoints P-3-3 Michihiro Takada(Department of Biostatistics, Kyoto University School of Public Health, Japan) Design and Analysis of Clinical Trials in Heterogeneous Population for Irreversible Endpoints: Application to Infertility Trials P-3-4 Takashi Asakawa(Department of Clinical Research Planning, Chugai Pharmaceutical Co., Ltd., Japan) A Dose-Finding Method Using Bayesian Model Averaging for Bivariate Binary Effi cacy and Toxicity Outcomes in Phase I Oncology Trials P-3-5 Motoi Odani(Department of Biostatistics, Kyoto University School of Public Health/Ono Pharmaceutical Co., Ltd., Japan) A Bayesian Approach for Evaluating the Consistency of Treatment Effects among Regions in Multi-Regional Clinical Trials P-3-6 Yoichi Ii(Clinical Statistics, Pfi zer Japan Inc., Japan) Sample Size Considerations in BE Studies Revisited P-3-7 Hyun Ju Park(Clinical Trial Center, Inha University Hospital, South Korea) A Study on Phase I Anti-Cancer Drug Clinical Trial Using Adaptive Design

31 XXVIth International Biometric Conference

P-3-8 Mizuki Yoshida(Biostatistics, Vaccine Research, Development Japan, Pfi zer Japan Inc., Japan) A Stochastic Curtailment Method Based on the Weighted Log-Rank Test for Delayed Treatment Effects P-3-9 J. Lynn Palmer(The University of Texas MD Anderson Cancer Center, USA) Addressing Missing Data in Melanoma-Related Quality of Life P-3-10 Ryuji Uozumi(Tokyo University of Science/Nippon Kayaku Co., Ltd., Japan) An Adaptive Subpopulation Selection Design Using Time-to-Event Endpoints P-3-11 Mariko Sumi(Clinical Development/Data Management, Actelion Pharmaceuticals Japan Ltd., Japan) An Adaptive Design for Dose-Finding Trials P-3-12 Mitsutoshi Uemori(Clinical Data and Biostatistics Department, Daiichi Sankyo Co., Ltd., Japan) Application of Non-Parametric Confi dence Interval for Median Difference with Example of Infl uenza Infection Non-Inferiority Clinical Trial P-3-13 Akihiro Hirakawa(Graduate School of Medicine, Nagoya University, Japan) An Adaptive Dose-Finding Approach for Correlated Bivariate Binary and Continuous Outcomes in Phase I Oncology Trials P-3-14 Jun Atsumi(Department of Management Science, Tokyo University of Science, Japan) A New Allocation Method for Balancing Prognostic Continuous and Categorical Variables in Clinical Trials P-3-15 Koji Oba(Translational Research and Clinical Trial Center, Hokkaido University Hospital, Japan) Indirect Treatment Comparisons in an Individual-Patient Data Meta-Analysis P-3-16 Kengo Nagashima(Department of Pharmaceutical Technochemistry, Josai University, Japan) A High-Speed Method for Population Pharmacokinetic Data Analysis in Genome-Wide Pharmacogenomic Studies

P-3-17 Cornelia Enǎchescu(Institute for Mathematical Statistics and Applied Mathematics, Romania) EDA Based Approach for Comparing Difussion Proﬁ le of Topical Drug Products P-3-18 Ikuko Funatogawa(Department of Public Health, Teikyo University School of Public Health, Japan) Estimation Methods of Pharmacokinetic Parameters in a Patient for a One-Compartment Model of a Single Bolus Intravenous Injection by a Single Sampling P-3-19 Kan F. Yee(Biostatistics, Akros Pharma, USA) Test of Dose Proportionality Under the Power Model P-3-20 Kentaro Sakamaki(Department of Biostatistics and Epidemiology, Yokohama City University, Japan) Graphical Procedures for Gatekeeping Applications P-3-21 Toshihiko Morikawa(Biostatistics Center, Kurume University (formerly), Japan) Explicit Solutions of Gatekeeping Procedures for Typical Hypothesis Structures P-3-22 Eric B. Laber(North Carolina State University, USA) Adaptive Inference after Model Selection P-3-23 Edwin M. M. Ortega(Departamento de Ciências Exatas - ESALQ/USP, Brazil) The Log-Kumaraswamy Generalized Gamma Regression Model with Application to Chemical Dependency Data P-3-24 Isao Yokota(Department of Biostatistics, School of Public Health, The University of Tokyo, Japan) Comparison of the Tests for Interval-Censored Survival Data with Differential Assessment Times P-3-25 Erik van Werkhoven(The Netherlands Cancer Institute , The Netherlands) A Variable Selection Mechanism Based on Effect Size Directly P-3-26 Rodrigo R. Pescim(University of São Paulo – ESALQ, Brazil) The New Class of Kummer Beta Generalized Distributions with Applications in Survival Analysis P-3-27 Nyakundi Wycliffe(Jomo Kenyatta University of Agriculture and Technology, Kenya) Accelerated Failure Time Frailty Model for CD4 Cells Count among the HIV AIDS Patients in the Westlands District Hospitals, Kenya P-3-28 Elizabeth Mie Hashimoto(Departamento de Ciências Exatas - ESALQ/USP, Brazil) The Log Gamma-Weibull Regression Model for Censored Data P-3-29 Ji Luo(School of Mathematics and Statistics, Zhejiang University of Finance and Economics, China) Estimation of Relative Risk Using Existing Function in R P-3-30 Nobutane Hanayama(Information Technology, Shobi University, Japan) A Discussion of Association between Risks for Breast and Liver Cancer by Analysing(Age, Period)-Tabulated Data

32 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

28 August (Tuesday): 16:15-18:00 16:15 JABES Showcase Session : Meritorious Papers in JABES by an IBS Member for 2010-11 International Chair : Linda J. Young (University of Florida, USA) conference room Sudipto Banerjee (University of Minnesota, USA) Improving Crop Model Inference through Bayesian Melding with Spatially Varying Parameters

16:15 Contributed 23 : Meta-Analysis #501 Chair : Hans C. van Houwelingen(Leiden University Medical Center, The Netherlands) 16:15 C-23-1 : Shiro Tanaka(Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Japan) A Test for Publication Bias in Mixed Treatment Comparison Meta-Analysis 16:32 C-23-2 : Hendriek C. Boshuizen(National Insititute of Public Health and the Environment/ Wageningen University and Research Centre, The Netherlands) Forestplots for Bivariate Meta-Analyses 16:49 C-23-3 : Michael Preuss(Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein) A New R Package for the Calculation of the Exact CDF of Q and I² for Meta-Analyses 17:06 C-23-5 : Eiji Sadashima(The Biostatistics Center, Kurume University, Japan) Meta-Analysis of Prognostic Studies for a Biomarker with a Study-Speciﬁ c Cut-Off Value

16:15 Contributed 24 : Bayesian Modeling and Biological Network #502 Chair : Tony Pettitt(Queensland University of Technology, Australia) 16:15 C-24-1 : Shigeki Nakagome(Department of Mathematical Analysis and Statistical Inference, Japan) Kernel Bayesian Computation 16:32 C-24-2 : K. Aruna Rao(Department of Statistics, Mangalore University, India) Bayesian Focussed Information Criterion: A New Variable Selection Criterion 16:49 C-24-3 : Hidehisa Noguchi(Tokyo University of Science, Japan) Bayesian Lasso for Selection of Reasonable Subsets

16:15 Contributed 25 : Causal Inference (2) #401 Chair : Els Goetghebeur(Ghent University, Belgium) + #402 16:15 C-25-1 : Emma Persson(Department of Statistics, Umeå University, Sweden) Covariate Selection for the Non-Parametric Estimation of Causal Effects in R: The Covsel Package 16:32 C-25-2 : Krista Fischer(Estonian Genome Genter, University of Tartu, Estonia) Causal Modeling in the Era of Population-Based Biobanks: Can "-Omics" Data Help? 16:49 C-25-3 : Ronnie Pingel(Department of Statistics, Uppsala University, Sweden) Effects of Collinearity on the Efﬁ ciency of Matching and Inverse Probability Weighting Estimators for Causal Inference 17:06 C-25-5 : Yongling Xiao(Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada) Estimation of the Cumulative Causal Treatment Effects in a Flexible Marginal Structural Cox Model

16:15 Contributed 26 : Analysis of Ecological Data (3) and Saturation Mutagenesis #503 Chair : Mihoko Minami(Keio University, Japan) + #504 16:15 C-26-1 : S. Lekwadi(Forestry, School of Agriculture and Food Science, University College Dublin, Ireland) Yield Models for the Thinned Sitka Spruce Forest Plantations in Ireland 16:32 C-26-3 : Jaime Felipe Medina Sotomayor(Center of Quantitative Methods, Department of Forest Sciences, College of Agriculture, University of Sao Paulo, Brazil) Above Ground Biomass Estimation Using Nonlinear and Mixed Effects Models in a Native Atlantic Rain Forest in Brazil 16:49 C-26-4 : Sue Welham(VSN International Ltd., UK) Assessing the Effect of Landscape on the Immigration of Pollen Beetles into Oilseed Rape Crops

28 August (Tuesday): 18:15-19:15 18:15 IBS General Meeting and Awards Presentation International conference room

33 XXVIth International Biometric Conference

30 August (Thursday): 08:45-10:30 08:45 Invited Session 8 : HER Databases and Long Term Observational Studies in the Study of Quality International of Care Assessment and Risk Factors for Outcomes – Bayesian and Frequentist Methods and conference room Limitations on Inference Organisers : Stijn Vansteelandt(Ghent University, Belgium), Jonas H. Ellenberg(University of Pennsylvania, Perelmen School of Medicine, USA) Chair : Theis Lange(University of Copenhagen, Denmark) 08:45 I-8-1 : Thomas A. Louis(Johns Hopkins Bloomberg School of Public Health, USA) Provider Comparisons: Identifying and Meeting Goals 09:10 I-8-2 : Els Goetghebeur(Ghent University, Belgium) Causal Inference for Center Effects on Quality of Care Under the No Unmeasured Time Varying Confounders and Instrumental Variables Assumption: A Frequentist Approach and Experience with Cancer Centers in Belgium 09:35 I-8-3 : Therese A. Stukel(Institute for Clinical Evaluative Sciences, Canada) Multispecialty Physician Network Coordination and Post-Discharge Care of Chronic Disease Patients 10:00 Discussant : Sharon-Lise T. Normand(Harvard Medical School, USA) 10:25 General Discussion and Questions

08:45 Contributed 27 : Modeling and Analysis of Infectious Disease #501 Chair : Kunihiko Takahashi(National Institute of Public Health, Japan) 08:45 C-27-1 : Aronrag Meeyai(CDPRG, London Sch of Hygiene & Tropical Med, Thailand) The Causes of Infl uenza Seasonality: A Time Series Analysis with Mechanistic Models 09:02 C-27-2 : Lawrence N. Kazembe(Department of Statistics, University of Namibia, Namibia) Bayesian Modelling of Zero-Altered Count Data with Application to Analysing Schistosomiasis Prevalence Infection and Intensity 09:19 C-27-3 : Jan van de Kassteele(National Institute for Public Health and the Environment - RIVM, The Netherlands) Age and Sex Specifi c Social Contact Patterns Stratifi ed by Location and Day of the Week 09:36 C-27-4 : Ahmadou Alioum(INSERM U897 Epidemiology and Biostatistics, Bordeaux Segalen University, France) Estimated HIV Incidence in France in Recent Periods, 2004-2010 09:53 C-27-5 : Fabio A. Milner(School of Mathematical and Statistical Sciences, ASU, USA) Could Changes in National Tuberculosis Vaccination Policies be Ill-Informed? 10:10 C-27-6 : Maya Gussmann(Friedrich-Loeffl er-Institute, Federal Research Institute for Animal Health, Brazil) Classifi cation of Infl uenza a Virus-Subtypes Using Mass Spectrometry

08:45 Contributed 28 : Survival Analysis: Interval Censoring #502 Chair : Bruce W. Turnbull(Cornell University, USA) 08:45 C-28-1 : Gul Inan(Department of Statistics,Middle East Technical University, Turkey) Bayesian Analysis for Interval-Censored Data with Missing Covariates 09:02 C-28-2 : Din Chen(Department of Biostatistics, University of Rochester, USA) Interval-Censored Time-to-Event Data in Biomedical Applications 09:19 C-28-3 : Osamu Kawaguchi(Sanoﬁ -Aventis K. K., Japan) Comparison of Two-Sample Tests for Partly Interval-Censored Survival Data 09:36 C-28-4 : Sachiko Tanaka(EBM Research Center, Kyoto University Graduate School of Medicine, Japan) Semiparametric Regression Analysis for Interval Censored Time-to-Event Data with Covariate Measured with Error 09:53 C-28-5 : Kuang-Fu Cheng(Biostatistics Center, China Medical University, Taiwan) A Method for Analyzing Clustered Interval-Censored Data Based on Cox's Model

34 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

30 August (Thursday): 08:45-10:30 (cont.) 08:45 Contributed 29 : Analysis of High-Dimensional Data (1) #401 Chair : Andrew Mead(University of Warwick, UK) + #402 08:45 C-29-2 : Ying Jiang(The Department of Biostatistics, Graduate School of Medicine, Kurume University, Japan) Variable Selection for Support Vector Machines Using the GBIC of the Kernel Logistic Regression 09:02 C-29-3 : Olivier Thas(Department of Mathematical Modelling, Ghent University, Belgium) Probabilistic Index Models for the Analysis of Microarray and qPCR Gene Expression Data 09:19 C-29-4 : V. S. Binu(Department of Statistics, Manipal University, Manipal, Karnataka, India) Uncertainty Estimation in Spot Intensity Ratio in Microarray Chip and Its Role in Identifying Differentially Expressed Genes 09:36 C-29-5 : Vittorio Perduca(Applied Mathematics Laboratory, Paris Descartes University and CNRS, France) Detecting Outliers in Hidden Markov Models Through Relative Entropy: Applications to Change-Point Detection 09:53 C-29-6 : Lieven Clement(I-BioStat, Katholieke Universiteit Leuven and Universiteit Hasselt, Belgium) Functional Mixed Models for Differential Expression Analysis of Next Generation Sequencing Data

08:45 Contributed 30 : Spatial Data Analysis (1) #503 Chair : Rasmus P. Waagepetersen(Aalborg University, Denmark) + #504 08:45 C-30-1 : Kenneth K. Lopiano(University of Florida, USA) Linear and Generalized Linear Regression Models with Spatially Misaligned Data 09:02 C-30-2 : Nathan M. Holt(University of Florida, USA) Spatio-Temporal Moran's I for Comparing Maps Across Time 09:19 C-30-3 : Renato Assuncao(Departamento de Ciencia da Computacao, Brazil) Covariance Decomposition in Multivariate Spatial Models 09:36 C-30-5 : Koudai Matsuyama(Graduate School of Engineering, Oita University, Japan) Improvements on ULS Scan Method for Event Time Data

30 August (Thursday): 08:45-12:45 08:45 Poster Presentation 4 Reception Hall P-4-1 Eisuke Inoue(School of Pharmacy, Kitasato University, Japan) Validity of Estimators for the Net Reclassifi cation Improvement Index with Censored Survival Data P-4-2 Takayuki Abe(Centre for Clinical Research, Keio University School of Medicine, Japan) Effect of Mixed-effects Model Selection in Comparing Two Correlated Free-response ROC(FROC) Curves Adjusted for Multiple Observers P-4-4 Eiji Nakatani(Statistical Analysis, Translational Research Informatics Center, Japan) New Risk Classifi cation Approach Using Bootstrap Estimate of Regression Tree Structure P-4-5 Akiko Kada(Research and Development Initiative Center, National Cerebral and Cardiovascular Center, Japan) Links between Prediction and Evaluation of Surrogate Endpoints Using Short Term Outcome in Discharge and Survival P-4-6 Heliton Ribeiro Tavares(Federal University of Pará, Brazil) A New Proposal for Volumetry Analysis of Magnetic Ressonance Imaging P-4-7 Scott Harris(Public Health Sciences and Medical Statistics, Faculty of Medicine, University of Southampton, UK) Sample Size Determination for Murine Experiments P-4-8 Yoichi M. Ito(Department of Biostatistics, Hokkaido University Graduate School of Medicine, Japan) Comparison of Risk Assessment Approaches for Adverse Drug Reactions in the Post-marketing Study P-4-9 Tatsuhiko Anzai(Statistical Analysis Depertment 1, EPS Corporation, Japan) An Extension of the Gamma Poisson Shrinker Method for Signal Detection Based on Spontaneous Adverse Drug Reaction Reports P-4-10 Dan Kajungu(INESS Project, INDEPTH Network, Ghana) Using Classifi cation Trees Analysis Methodology Model to Investigate Predictors of Drug Prescription Practices at Health Facilities in Rural Tanzania P-4-11 Ram Kishore Gupta(National Institute of Medical Statistics, India) Identifying Factors Predisposing Youths to Risky Sexual Behaviour in India Using Logistic Regression Analysis P-4-12 Satoshi Usami(Tokyo Institute of Technology, Japan) Multivariate Mean-based Mixture Modelling in Longitudinal Data Analysis

35 XXVIth International Biometric Conference

P-4-13 M. Piccardi(Statistics and Biometry. Agricultural College at the National University of Córdoba, Spain) Modeling Lactation Curves in Dairy Cows with Linear, Non-Linear and Mixed Models P-4-14 Ho Ming Yuen(Primary Care & Population Sciences, University of Southampton, UK) Are We Relying on More Continuous Treatments for Depression? The Three Rolling 10-Year Cohorts from the General Practice Research Database P-4-15 Kenichi Satoh(Department of Environmetrics and Biometrics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan) Statistical Inference for Linear Varying Coeffi cients and Its Applications P-4-16 Julio A. Di Rienzo(Facultad de Ciencias Agropecuarias-Universidad Nacional de Córdoba, Argentina) A Friendly Interface to the LME4 Library in R P-4-17 Lieketseng Masenyetse(Biostatistics Unit; South Africa Medical Research Council, South Africa) An Analysis of Biomarkers and Time to Event Measures in HIV/AIDS Patients in a South African Pharmacovigilance Study P-4-18 Samuel O. M. Manda(Biostatistics unit, South African Medical Research Council, South Africa) Expectation-Maximization Estimation of Joint Longitudinal Model for Multiple Repeated Measures and Multiple Recurrent Events Processes P-4-19 Pauline Ding(Mathematical Science Institute, and Statistical Consulting Unit, the Australian National University, Australia) Analysing Longitudinal Data with Multiple Random Variations Using GEE P-4-20 Hope I. Mbachu (Department of Statistics, Imo State University, Nigeria) Designing a Pseudo-R Squared Goodness of Fit Measure in Generalized Linear Model P-4-21 Hirotaka Mano(Department of Management Science, Tokyo University of Science, Japan) Improvement of Trim and Fill Method to Adjust Publication Bias in Meta-Analysis Using the Clinical Trial Registration System P-4-22 Takashi Omori(Faculty of Culture and Information Science, Doshisha University, Japan) Educational Cards for Introducing Biostatistical Concepts on Clinical Trial P-4-23 Ayako Matsuda(Surveillance Division Center for Cancer Control and Information Services, National Cancer Center, Japan) Multivariate Meta-Analysis on Quality of Life of Early Breast Cancer Patients P-4-24 Sheng-Tsung Yu(Division of Preventive Medicine and Health Services Research, Institute of Population Sciences, National Health Research Institutes, Taiwan, ROC) Validation of EQ-5D in Taiwan: Results of 2009 NHIS in Taiwan P-4-25 Mbanefo Solomon Madukaife(University of Nigeria Nsukka, Nigeria) A Modifi cation of Royston's Transformation of Wilk-Shapiro W Statistic for Testing Univariate Normality P-4-26 Sara Gustavsson(Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy at Gothenburg University, Sweden) Linear Regression Analysis on Log-Normal Exposure Data P-4-28 Crysttian Arantes Paixão(Applied Mathematics School, Getulio Vargas Foundation, Brazil) Fisher's Discriminant Function the Alternative of MANOVA P-4-29 Marisol García-Peña(Departamento de Ciências Exatas, Universidade de São Paulo, Brazil) A Comparison between Robust Locally Weighted Regression and Response Surfaces for Experimental Designs in the Presence of Infl uential Data P-4-30 Misa Adachi(Nutrition Support Network LLC, Japan) Effects of Lifestyle Education Program for Type 2 Diabetes Patients in Clinics: A Cluster Randomized Trial

30 August (Thursday): 11:00-12:45 11:00 Invited Session 9 : Data Visualization:Optimization and Applications International Organiser : Ross Darnell(CSIRO Mathematics, Australia) conference Chair : Ross Darnell room 11:00 I-9-1 : Antony Unwin(Universität Augsburg, Germany) Interactive Graphics and Multiple Datasets: The Complexities of Linking Information 11:25 I-9-2 : Natsuhiko Kumasaka(Center for Genomic Medicine, RIKEN, Japan) A Haplotype Visualization of Multi-Allelic Genetic Markers 11:50 I-9-3 : Ritei Shibata(Keio University, Japan) Visualising Relationships between Multi-Species Measures of Biodiversity and the Environment

12:15 I-9-4 : Michael Lawrence(Genentech, USA) Large Data, Wide Spaces: Leveraging Computation and Statistics for the Visual Exploration of Genomic Data 12:40 General Discussion and Questions

36 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

30 August (Thursday): 11:00-12:45 (cont.)

11:00 ISI Special Invited Session:Statistical Methods of Risk Assessment on the Health Effect of the Environment #501 Organiser : Byung-Soo Kim(Yonsei University, South Korea) Chair : Byung-Soo Kim 11:00 Tsuyoshi Nakamura(Chuo University, Japan)and D. G. Hoel(Medical University of South Carolina, USA) Mathematical and Computational Base for Valid Inference with the Two-Stage Clonal Expansion Model 11:23 Annette Kopp-Schneider(German Cancer Research Center, Germany) A Review on the State of the Art in Carcinogenesis Models 11:46 Yiliang Zhu(University of South Florida, USA) Statistical Estimation of Physiologically-Based Pharmacokinetic and Pharmacodynamic Models with Application to Risk Assessment of Dioxin and Dioxin-Like Compounds 12:09 Yongdai Kim(Seoul National University, South Korea) Estimation of Epidemiological Effect of Meteorological Change 12:32 General Discussion and Questions

11:00 Contributed 31 : Survival Analysis: Competing Risks #502 Chair : Niels Keiding(University of Copenhagen, Denmark) 11:00 C-31-1 : Niels Keiding(Department of Biostatistics, University of Copenhagen, Denmark) Censoring and Competing Risks Problems in the Current Duration Approach to Monitoring Time to Pregnancy 11:17 C-31-2 : Masako Nishikawa(National Institute of Public Health, Japan) On the Adjustment of the Cause-Speciﬁ c Log-Rank Test in Competing Risks Data

11:34 C-31-3 : Jinheum Kim(Department of Applied Statistics, University of Suwon, South Korea) Cut-off Value Determination Method for the Survival Data with Competing Risks 11:51 C-31-4 : Karri Seppä(Department of Mathematical Sciences, University of Oulu, Finland) Regional Variation in Relative Survival – Quantifying the Effects of the Competing Risks of Death Using Cure Fraction Model with Random Effects 12:08 C-31-5 : M. A. Nicolaie(Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, The Netherlands) Dynamic Pseudo-Observations: A Robust Approach to Dynamic Prediction in Competing Risks

11:00 Contributed 32 : Analysis of High-Dimensional Data (2) #401 Chair : Olivier Thas(Ghent University, Belgium) + #402 11:00 C-32-1 : Hae-Won Uh(Department Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands) Search for Multiple Biomarkers Predicting Longevity in Families Using Weighted Penalized Logistic Regression 11:17 C-32-2 : Jin Liu(School of Public Health, Yale University, USA) Incorporating Group Correlations in Genome-Wide Association Studies Using Smoothed Group Lasso 11:34 C-32-3 : Andrew Mead(School of Life Sciences, University of Warwick, UK) Designing the Microarray Phase of Two-Channel Microarray Experiments 11:51 C-32-4 : Philip Law(Warwick Systems Biology, University of Warwick, UK) Clustering Cross-Sectional Time Series Gene Expression Proﬁ les Using Parametric Regression Models 12:08 C-32-5 : Reiichiro Nakamichi(Department of Aquatic Biosciences, Tokyo University of Marine Science and Technology, Japan) Inference of Direct Effect and Module Structure of Transcriptome Behind Phenotype via Graphical Modelling 12:25 C-32-6 : Benoit Liquet(University Bordeaux, France) A Novel Approach for the Integration of Repeated Measures Experiments and Biomarker Selection

11:00 Contributed 33 : Spatial Data Analysis (2): Application #503 Chair : Yoichi Ito(Hokkaido University, Japan) + #504 11:00 C-33-1 : Dolores Catelan(Department of Statistics "G. Parenti" University of Florence, Italy) Geostatistical Model Based Estimates of Probability of Parasitic Infection in a Southern Italian Region 11:17 C-33-2 : Nicola F. Reeve(CHICAS, Lancaster Medical School, Lancaster University, UK) Spatial Methods for Analysis of Cancer Incidence and Mortality in Vicinity of Large Incinerators in England 1998-2008 11:34 C-33-3 : Ngianga-Bakwin Kandala(University of Warwick, Warwick Medical School, Division of Health Sciences, Populations, Evidence and Technologies Group, UK) Childhood Mortality in the Democratic Republic of Congo(DRC): An Application of a Bayesian Geo-Additive Discrete-Time Survival Model 11:51 C-33-4 : Oyelola A. Adegboye(Department of Science and Mathematics, The American University of Afghanistan, Afghanistan) Spatial Analysis of Malaria Incidence in Africa: An Efﬁ cient Parameter Estimation in the Premise of Generalized Estimating Equation 12:08 C-33-5 : S. K. Appiah(School of Engineering, Faculty of Computing Health Science, Edith Cowan University, Australia) Space-time Modelling of Climate Effect on Malaria Morbidity Cases in Ghana, West Africa 37 XXVIth International Biometric Conference

30 August (Thursday): 14:00-15:45 14:00 Invited Session 10 : Design and Analysis of Clinical Trials for Predictive Medicine: New Paradigm International and Challenges conference Organiser : Shigeyuki Matsui(The Institute of Statistical Mathematics, Japan) room Chair : Shigeyuki Matsui 14:00 I-10-1 : Marc Buyse(International Drug Development Institute and Hasself University, Belgium) An Overview of Biomarker-based Clinical Trial Designs 14:25 I-10-2 : Stefan Michiels(Institut Jules Bordet, Belgium) Clinical Trial Designs Using Gene Signatures 14:50 I-10-3 : William E. Barlow(Cancer Research and Biostatistics, USA) Designing a Randomized Trial to Test an Interaction of Treatment and a Continuous Genomic Assay 15:15 I-10-4 : Shigeyuki Matsui(The Institute of Statistical Mathematics, Japan) Developing and Validating Continuous Genomic Signatures in Randomized Clinical Trials 15:40 General Discussion and Questions

14:00 Contributed 34 : Analysis of Imaging Data #501 Chair : Young K. Truong(The University of North Carolina at Chapel Hill, USA) 14:00 C-34-1 : Atsushi Kawaguchi(Biostatistics Center, Kurume University, Japan) Analysis of Structural Brain MRI Data in Longitudinal Study 14:17 C-34-2 : Yuko Araki(Biostatistics Center, Kurume University, Japan) Two-Way Regularized Functional Classifi cation for High Dimensional Brain MRI Data 14:34 C-34-3 : Young K. Truong(Department of Biostatistics, UNC-CH, USA) Independent Component Analysis Involving Autocorrelated Sources with an Application to fMRI 14:51 C-34-4 : Pietro Franceschi(Biostatistics and Data Management, Fondazione Edmund Mach San Michele all'Adige(TN), Italy) New Tools for the Analysis of Mass Spectrometry Based Metabolic Images of Plant Tissues 15:08 C-34-5 : Masaru Ushijima(Japanese Foundation for Cancer Research, Japan) Analysis of Image Patterns for Imaging Mass Spectrometry Data 15:25 C-34-6 : Jan Scherks(Czech Technical University in Prague Faculty of Transportation Sciences, Department of Informatics and Telecommunications, Czech Republic) Scanning Device Infl uence to User Biometric Verifi cation by Ear Geometrics

14:00 Contributed 35 : Modeling and Analysis of Environmental Data #502 Chair : Megu Ohtaki(Hiroshima University, Japan) 14:00 C-35-2 : Ryo Kiguchi(Department of Mathematics, Keio University, Japan) Cyclic Cubic Regression Spline Smoothing and Analysis of CO2 Data at Showa Station in Antarctica 14:17 C-35-3 : Hyewon Lee(Graduate School of Public health, Seoul National University, South Korea) The Effects of Asian Dust Storms on Daily Mortality in Seoul, Korea during 2001-2009 14:34 C-35-4 : Legesse Kassa Debusho(Department of Statistics, University of Pretoria, South Africa) Probabilistic Downscalign of Precipitation at Selected Stations across South Afric

14:00 Contributed 36 : Analysis of High-Dimensional Data (3) #401 Chair : Sean L. Simpson(Wake Forest University School of Medicine, USA) + #402 14:00 C-36-1 : Noriko Tanaka(NSABP Biostatistical Cntr, Department of Biostatistics/University of Pittsburgh Graduate School of Public Health, USA) Supremum Test Statistic to Screen Genomic Marker with Non-Linear Interaction Effect 14:17 C-36-2 : Matthew E. Ritchie(Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Australia) Improved Genotype Calling for Rare Variants 14:34 C-36-3 : Susana Pérez-Álvarez(Institut de Recerca de la SIDA irsiCaixa – HIVACAT, Hospital Universitari Germans Trias i Pujol, Spain) Model Selection with a New Technique: Farms 14:51 C-36-4 : Sean L. Simpson(Department of Biostatistical Sciences, Wake Forest University School of Medicine, USA) Kronecker Product Linear Exponent Auto Regression Correlation Structures and Separability Tests for Multivariate Repeated Measures 15:08 C-36-5 : The Minh Luong(Université Paris Descartes, France) Fast Model Selection in Change-Point Models through a Constrained Hidden Markov Model and the Integrated Complete Likelihood 15:25 C-36-6 : Gota Morota(Department of Animal Sciences, University of Wisconsin-Madison, USA) Application of Bayesian and Sparse Network Models for Assessing Linkage Disequilibrium in Animals and Plants

38 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

30 August (Thursday): 14:00-15:45 (cont.) 14:00 Contributed 37 : Species Abundance/Biodiversity #503 Chair : Hans J. Skaug(University of Bergen, Norway) + #504 14:00 C-37-1 : Masaaki Sibuya(Faculty of Science and Engineering, Keio University, Japan) Species Abundance Distributions and Random Partitions of Number 14:17 C-37-2 : Clarice G. B. Demétrio(Departamento de Ciências Exatas, Universidade de São Paulo, Brazil) The Ecological Footprint of Taylor's Universal Power Law 14:34 C-37-3 : Philip Pallmann(Institute of Biostatistics, Leibniz University Hannover, Germany) Comparing Biodiversity by Simultaneously Testing a User-deﬁ ned Selection of Diversity Indices 14:51 C-37-4 : Pieter M. Kroonenberg(Insitute of Education and Child Studies, Leiden University, The Netherlands) Analysing Whole Community Experiments in Ecology by Three-way Correspondence Analysis 15:08 C-37-5 : Lise Vaudor(UMR 5600, CNRS, Environnement Ville Société, France) Which Sampling Strategies Should be Adopted to Assess Effects of Restoration Operations on Population Abundances? 15:25 C-37-6 : Hideyasu Shimadzu(Department of Mathematics, Keio University, Japan) Accounting for Sampling Effects in Biodiversity Modelling

30 August (Thursday): 14:00-18:00 14:00 Poster Presentation 5 Reception Hall P-5-1 Ron Wehrens(Biostatistics and Data Management, Fondazione Edmund Mach San Michele all'Adige(TN), Italy) Biomarker Selection in R: The Biomark Package P-5-2 Tohru F. Yamaguchi(Health Care Food Research Labs, Kao Corporation; Graduate School of Advanced Science and Technology, Tokyo Denki University, Japan) Radiation-Free Imaging of Human Abdominal Fat Realized by Solving the Inverse Problem of Electrical Impedance Tomography P-5-3 Jiaxu Zeng(University of Otago, New Zealand) Bootstrapped Model-Averaged Conﬁ dence Intervals P-5-4 Vedpal Singh(Dbit, Dehradun, India) Normalized Cross Correlation Based Matching Algorithm P-5-5 Young Ju Suh(Department of Clinical Research, School of Medicine, Inha University, South Korea) Comparison of Statistical Model for the Linkage Analysis of a Quantitative Trait P-5-7 Maria J. Batista(Department of Statistics, Federal University of Ceara, Brazil) Conditional Logistic Regression as an Alternative to the TDT in Trios Design P-5-8 Seonwoo Kim(Samsung Biomedical Research Institute, South Korea) Prediction Model for Response to Antidepressant Drugs Using Genomic Markers P-5-9 Tiago M. Fragoso(Department of Statistics, University of Sao Paulo, Brazil) Construction of a Metabolic Syndrome Scale and Joint Heritability Using Item Response Models P-5-10 Jhonny Demey(Instituto de Estudios Avanzados(IDEA). Caracas, Venezuela) Logistic Biplots for Comparative Proteomic Analysis P-5-11 Andrea Peña Malavera(Biometry Unit, College of Agriculture, Argentina) On the Performance of Procedures to Determine Genetic Population Structure P-5-13 Luiz Alexandre Peternelli(Departamento de Estatística da Universidade Federal de Viçosa, Brazil) Multivariate Imputation of Data in Field Experiment P-5-14 Florent Baty(Division of Pulmonary Medicine, Cantonal Hospital St. Gallen, Switzerland) Exploring Patterns of Transcription Factor Activity in High-throughput Gene Expression Data Using RLQ Analysis P-5-15 Shuhei Kaneko(Department of Management Science, Tokyo University of Science, Japan) Gene Selection Using a High-Dimensional COX Model in Microarray Data Analysis P-5-17 Kana Yamada(Department of Management Science, Tokyo University of Science, Japan) Operating Characteristics of the Penalized COX Regression Analysis in High-Dimensional Microarray Data P-5-18 Motomi Mori(Biostatistics Shared Resource and Integrative Genomics Laboratory, Knight Cancer Institute, Oregon Health & Science University, USA) Statistical Considerations for the Analysis of Affymetrix Micro RNA Array Data P-5-19 Pablo Ramon(Instituto de Ecología, Universidad Técnica Particular de Loja-Ecuador, Center of Quantitative Methods, Department of Forest Sciences, University of São Paulo-BR., Ecuador) Croton Wagneri Spatial Structure Analysis with Modiﬁ ed Ripley's K Function in Ecuadorian Dry Tropical Forests P-5-20 Hwan-Jin Yoon(Statistical consulting Unit, The Australian National University, Australia) Estimating Repeatability Using Hierarchical Generalized Linear Models(HGLM)

39 XXVIth International Biometric Conference

P-5-21 Emanuelle Arantes Paixão(Departamento de Biologia, Universidade Federal de Lavras – UFLA, Brazil) The Inﬂ uence of the Intra-Speciﬁ c Competition in the Growth and Development of Bean Plant Under Different Fertilization Levels P-5-22 Tetsuji Tonda(Department of Environmetrics and Biometrics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan) Estimation of Spatial-Time Distribution of Cancer Mortality among Atomic Bomb Survivors in Hiroshima P-5-23 Jupiter Simbeye(Mathematical Sciences Department, University of Malawi, Malawi) Spatial Dependence in HIV Prevalence in Malawi: A Bayesian Simulation Study P-5-24 Mzabalazo Z. Ngwenya(Agricultural Research Council(ARC) Biometry Unit, South Africa) On the Estimation of the Kriging Variance P-5-25 Mee Yoon Choo(The University of Memphis, USA) Spatial and Landscape Genetics of Native Species for Restoration and Conservation P-5-26 Naoki Nishimoto(Center for Translational Research, Hokkaido University, Japan) Exploring Weighting Schemes between Report Assignments on Medical Informatics Written by Nursing and Radiologic Technology Students P-5-27 Nombasa Ntushelo(Agricultural Research Council(ARC)-Biometry Unit, South Africa) Exploratory Multivariate Statistical Techniques for Multidimensional Data with Applications in R P-5-28 Haruo Yanai(St. Lukes College of Nursing; Oita University of Nursing and Health Sciences, Japan) Development of Computer Based Testing for a Common Achievement Test for Nursing Colleges(CATNC) in Order to Maintain Students' Competency for Practical Nursing - With Emphasis on the Analysis of Reliability and Validity of the Test - P-5-29 Kaoru Shimada(Division of Public Health & Human Sciences Fukuoka Dental College, Japan) A Contrast Rule Mining Method for Incomplete Database Based on Evolutionary Rule Accumulation Mechanism P-5-30 Takashi Murakami(Department of Sociology, Chukyo University, Japan) Multiple Correspondence Analysis of Guttman Perfect Scale and a Geometrical Explanation of the Horse-Shoe Effect P-5-31 Oyelola A. Adegboye(Department of Science and Mathematics, The American University of Afghanistan, Afganistan) Disease Mapping of Malaria Incidence in Sub-Sahara Africa

P-5-32 Mónica Balzarini(Cátedra de Estadística y Biometría, Universidad de Córdoba, Argentina) On the Relative Performance of Statistical Methods to Analyze Genetic Data in a Spatially Explicit Framework

30 August (Thursday): 16:15-18:00 16:15 Invited Session 11 : Exposure Reconstruction and Exposure Uncertainty in Epidemiological International Studies of Radiation Health Effects conference Organiser : Harry M. Cullings(Radiation Effects Research Foundation, Japan) room Chair : Kyoji Furukawa(Radiation Effects Research Foundation, Japan) 16:15 I-11-1 : Dan Stram(University of Southern California, USA) A Statistical Approach to Using Biodosimeters that May Have a Direct Causal Relation to Outcome in Radiation Dose Uncertainty Problems 16:40 I-11-2 : C. Y. Wang(Fred Hutchinson Cancer Research Institute, USA) A Functional Approach to Dose Error Using Biodosimetry Data 17:05 I-11-3 : Kazutaka Doi(National Institute of Radiological Sciences, Japan) Extensions to the Regression Calibration and Substitution Approach to Mitigating the Impact of Dosimetric Uncertainty on Risk Regression 17:30 Discussant : Harry Cullings(Radiation Effects Research Foundation, Japan) 17:55 General Discussion and Questions

16:15 Young Statisticians Showcase Session #501 Chair : Peter Njuho(University of Venda, South Africa) 16:15 Lucy Campbell(University of Cape Town and International Epidemiological Database for the Evaluation of AIDS, South Africa) Comparison of Methods for Survival Analysis in the Presence of Competing Risks and Non-Proportional Hazards 16:32 Genevera Allen(Department of Statistics, Rice University, USA) Regularized Tensor Factorizations and Higher-Order Principal Component Analysis 16:49 E. P. Sreedevi(Department of Statistics, Pondicherry University, India) A Proportional Hazards Model for the Analysis of Doubly Censored Competing Risks Data 17:06 Birgit Witte(Department of Epidemiology and Biostatistics, VU University Medical Center, The Netherlands) Incorporating Sensitivity of Diagnostic Tests in Estimation Methods for Interval Censored Data 17:23 Mariano Augusto Córdoba(Statistics and Biometry Unit, College of Agriculture, National University of Cordoba, Argentina) Multivariate Spatial Variability in Soil Variables and Grain Yields at Fine Scale

40 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

30 August (Thursday): 16:15-18:00 (cont.) 16:15 Contributed 38 : Longitudinal Data: Analysis #502 Chair : Victor Kipnis(National Cancer Institute, USA) 16:15 C-38-1 : Victor Kipnis(Division of Cancer Prevention, National Cancer Institute, USA) A New Multivariate Measurement Error Model for Longitudinal Correlated Semicontinuous and Continuous Data, with Application to Nutritional Epidemiology 16:32 C-38-2 : Tanguy Jérôme(Danone Research, France) Joint Analysis of Multivariate Ordinal Longitudinal Variables: Application to Clinical Trials in Nutrition 16:49 C-38-3 : Jaakko Nevalainen(Department of Mathematics and Statistics, University of Turku, Finland) Fitting Regression Splines with Subject Speciﬁ c Smoothing on BMI Data on Children 17:06 C-38-4 : Yingsi Yang(Department of Mathematics The Hong Kong University of Science & Technology Hong Kong, China) Poisson and Negative Binomial Regressions with Measurement Error in Covariates: An Application to Hong Kong Birth Cohort

17:23 C-38-5 : Montip Tiensuwan(Department of Mathematics, Faculty of Science, Mahidol University, Thailand) Recurrence of Colorectal Cancer Using Nonlinear Mixed-Effects Models 17:40 C-38-6 : Madalitso R. Tolani(University of Malawi, Chancellor College, Malawi) Modelling Longitudinal Count Data with Non-Ignorable Dropouts: An Application to CD4+ Counts in HIV-Infected Patients

16:15 Contributed 39 : Analysis of Multidimensional Biomarker and Data Mining (1) #401 Chair : Mark R. Segal(University of California, USA) + #402 16:15 C-39-1 : Nell Sedransk(National Institute of Statistical Sciences, USA) Quantitation of Proteomic Biomarkers: Solving Statistical Issues Arising from Heterogeneity of Variance 16:32 C-39-2 : Mark R. Segal(Bioinformatics, University of California, USA) Issues in Constructing 3D Chromosome Conﬁ gurations from Chromatin Conformation Capture Assays 16:49 C-39-3 : Adam B. Olshen(Department of Epidemiology and Biostatistics, University of California, USA) Statistical Methods for the Analysis of Ribosome Proﬁ ling Data 17:06 C-39-4 : Kasper Brink(Department of Basic Sciences, University of Copenhagen, Denmark) A Two-Step Model for Gene Selction in a Cassava Metabolite Network 17:23 C-39-5 : Jos A. Hageman(Biometris - Applied Statistics, Wageningen Univerisity, The Netherlands) Assessment of Utility of Joining Predictor Sets from Different Platforms in Metabolomics Studies: A Criterion for Data Fusion 17:40 C-39-6 : Maiju E. Kujala(Department of Mathematics and Statistics, University of Turku, Finland) A Case-Study of Normalization, Variable Selection and Regression Methods in Lipidomics

16:15 Contributed 40 : Diagnostic Test #503 Chair : Satoshi Morita(Yokohama City University, Japan) + #504

16:15 C-40-1 : Yoshiko Aoyama(Department of Biostatistics, Graduate School of Medicine, Kurume University, Japan) Comparing Two Diagnostic Tests When Two Tests are Applied to Same Patients and Test Scores are Given in Categories

16:32 C-40-2 : Kenta Murotani(Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Japan) Follow-up Design for Comparing Two Binary Diagnostic Tests 16:49 C-40-3 : Brandy M. Ringham(Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, USA) Reducing Decision Errors in the Paired Comparison of the Diagnostic Accuracy of Continuous Screening Tests

17:06 C-40-5 : Youyi Fong(Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, USA) Combining Biomarkers Nonlinearly for Classiﬁ cation Using the Area Under the ROC Curve 17:23 C-40-6 : Yuan-chin Ivan Chang(Institute of Statistical Science, Academia Sinica, Taiwan) Finding the Optimal Linear Combination of Markers that Maximizes an AUC-type Measure When the Gold Standard is Continuous

41 XXVIth International Biometric Conference

31 August (Friday): 08:45-10:30 08:45 IInvited Session 12: Statistical Methods for Reducing Batch Effects, Summarization and Gene International Filtering in High-Throughput Genomic Data conference Organisers : Lieven Clement(Katholieke Universiteit Leuven,Belgium), room Ziv Shkedy(Universiteit Hasselt, Belgium) Chair : Lieven Clement 08:45 I-12-1 : Jeff Leek(Johns Hopkins University, USA) Dealing with Batch Effects and Latent Confounders in Genomic Applications 09:05 I-12-2 : Matthew N. McCall(University of Rochester, USA) Summarization of Affymetrix GeneChip Probe Level Data: from RMA to Frozen RMA(fRMA) 09:25 I-12-3 : Djork-Arné Clevert(Johannes Kepler University of Linz, Austria) FARMS: A Generative Framework for Microarray Data Processing 09:45 I-12-4 : Adetayo Kasim(Durham University, UK) Informative or Noninformative Calls for Gene Expression in Microarray Experiments: A Latent Variable Approach 10:05 Discussant : Willem Talloen(Janssen Phamacutical, Beerse, Belgium) 10:25 General Discussion and Questions

08:45 Fisher's 50th Memorial Session #501 Organiser : Kaye E. Basford(University of Queensland, Australia) Chair : Kaye E. Basford 08:45 Lynne Billard(University of Georgia, USA) The International Biometric Society and Fisher Oliver Mayo(CSIRO Livestock Industries, Australia) Fisher in Adelaide

08:45 Contributed 41 : Survival Analysis: Inference #502 Chair : David E. Matthews(University of Waterloo, Canada) 08:45 C-41-1 : David E. Matthews(Statistics & Actuarial Science, University of Waterloo, Canada) Exact Nonparametric Conﬁ dence Bands for the Survivor Function 09:02 C-41-2 : Philippe Saint-Pierre(Université Pierre et Marie Curie – Paris VI Laboratoire de Statistique Théorique et Appliquée, France) Kaplan-Meier Type Integrals for Bivariate Right Censored Data 09:19 C-41-4 : K. Vikas(Department of Statistics, Mangalore University, India) Empirical Likelihood Ratio Test for Equality of Co-efﬁ cient of Variation in Log-Location-Scale Family 09:36 C-41-5 : Kwun Chuen Gary Chan(Department of Biostatistics, University of Washington, USA) Survival Analysis without Survival Data

08:45 Contributed 42 : Application of Bayesian Method in Medical/Epidemiological Research #401 Chair : Thomas A. Louis(Johns Hopkins Bloomberg School of Public Health, USA) + #402 08:45 C-42-1 : Yinghui Wei(MRC Biostatistics Unit, Institute of Public Health Robinson Way, UK) A Bayesian Approach for Multivariate Meta-Analysis with Many Outcomes 09:02 C-42-2 : Kentaro Takeda(Biostatistics Group, Data Science, Development, Astellas Pharma Inc., Japan) Practical Use of Modiﬁ ed Continual Reassessment Methods for a Phase I Dose-Finding Study in a New Region: Simulation-Based Comparisons 09:19 C-42-3 : Su Chen(Department of Biostatistics, School of Public Health, University of Michigan, USA) A Bayesian Approach of Testing for Serial Homogeneity in the Correlation of Longitudinally Measured Biomarkers 09:36 C-42-4 : Ickstadt Katja(Department of Statistics, TU Dortmund University, Germany) Spatial Modelling of Ras Protein Structures on the Cellular Membrane 09:53 C-42-5 : Laura Grisotto(Department of Statistics "G. Parenti" University of Florence, Italy) A Bayesian Universal Kriging Model to Predict Pollutant Concentrations for the Lombardy Region in Italy

42 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

31 August (Friday): 08:45-10:30 (cont.) 08:45 Contributed 43 : Optimal Design and Related Topics #503 Chair : Chris Brien(University of South Australia, Australia) + #504 08:45 C-43-1 : Sally Galbraith(School of Mathematics and Statistics, The University of New South Wales, Australia) Guidelines for Designing Accelerated Longitudinal Studies 09:02 C-43-2 : Kari Tokola(School of Health Sciences, University of Tampere, Finland) Design and Cost Optimization for Hierarchical Data 09:19 C-43-3 : Verity Fisher(Faculty of Health and Social Sciences, University of Southampton, UK) Optimal Designs for Nonparametric Estimation with Application to Functional Data 09:36 C-43-4 : Alia Sajjad(Department of Statistics, Quaid-iAzam, University Islamabad, Pakistan) Using Electric Resistances to Find A-optimal Block Designs When the Concurrence Graphs are Sparse 09:53 C-43-5 : Chris Brien(Phenomics and Bioinformatics Research Centre, University of South Australia, Australia) Principles in the Design of Multiphase Experiments with a Later Laboratory Phase: Orthogonal Designs

31 August (Friday): 11:00-12:45 11:00 Invited Session 13 : International Collaborations and Networking of the Biometricians to Develop International Statistical Methodologies and to Solve Global Statistical Issues conference Organisers : Toshihiko Morikawa(Osaka, Japan), room Geert Molenberghs(Hasselt University,Belguim) Chairs : Toshihiko Morikawa Geert Molenberghs 11:00 Introduction : Toshihiko Morikawa 11:05 I-13-1 : Miodrag Lovric(University of Kragujevac, Serbia) Motivation and Experience in Editing the International Encyclopedia of Statistical Science 11:25 I-13-2 : Geert Molenberghs(Hasselt University, Belgium) The Biostatistical Scientist in a High-Proﬁ le Collaborative Environment 11:45 I-13-3 : Shigeyuki Matsui(The Institute of Statistical Mathematics, Japan) Networking Clinical Biostatisticians in Japan 12:05 I-13-4 : Scott Evans(Harvard University, USA) Experiences and Thoughts about International Collaborations 12:25 General Discussion in a Round Table Format 12:40 Session Summary and Final Comments : Geert Molenberghs

11:00 Contributed 44 : Disease Monitoring and Screening #501 Chair : Taerim Lee(Korea National Open University, South Korea) 11:00 C-44-1 : Artemis Koukounari(Infectious Disease Epidemiology, Imperial College, UK) Multilevel Latent Markov Models for the Evaluation of Diagnostic Accuracy 11:17 C-44-2 : M. C. Elze(Department of Statistics, University of Warwick, UK) Modelling Survival Following Bone Marrow Transplantation Using Longitudinal Immune Measurements at Arbitrary Time Points

11:34 C-44-3 : Benjamin French(Department of Biostatistics and Epidemiology, University of Pennsylvania, USA) Development and Evaluation of Multi-Marker Risk Scores for Clinical Prognosis 11:51 C-44-4 : Timothy R. Church(Division of Environmental Health Sciences, University of Minnesota School of Public Health, USA) A Recurrence-Time Model to Estimate Preclinical Incidence, Preclinical Duration, and Survival Under Periodic Screening Accounting for Length-Bias 12:08 C-44-5 : Taerim Lee (Department of Information Statistics, Korea National Open University, South Korea) Symbolic Tree for Prognosis of Localized Osteosarcoma Patient

43 XXVIth International Biometric Conference

11:00 Contributed 45 : Survival Analysis: Modeling (1) #502 Chair : Chikuma Hamada(Tokyo University of Science, Japan) 11:00 C-45-2 : Junichi Asano(Department of Management Science, Tokyo University of Science, Japan) A Stepwise Variable Selection for a COX Proportional Hazards Cure Model 11:17 C-45-3 : Takeshi Emura(Graduate Institute of Statistics, National Central University, Taiwan) Survival Prediction Based on Compound Covariate Method under Cox Proportional Hazard Models with Microarrays 11:34 C-45-4 : Yang Xia(Biostatistics Unit, Medical Research Council, UK) A Generalised Mover-Stayer Model for Repeated Events Survival Data: An Identiﬁ ability Problem 11:51 C-45-5 : Zhipeng Hao(Statistics department, Macquarie University, Australia) Semi-Markov Model in Recurrent Events Analysis 12:08 C-45-6 : Virginie Rondeau(University Bordeaux, France) Investigating Hospital Heterogeneity with a Multi-State Frailty Model: Application to Nosocomial Pneumonia Disease in Intensive Care Units

11:00 Contributed 46 : Analysis of Multidimensional Biomarker and Data Mining (2) #401 Chair : James J. Chen(US Food and Drug Administration, USA) + #402 11:00 C-46-1 : Martha Muller(Department of Mathematics and Statistics, Faculty of Natural and Life Science, University of Copenhagen, Denmark) Wavelet-Based Functional Mixed Models with Application to NMR Metabolomic Data in Human Nutrition 11:17 C-46-2 : W. B. Yahya(Department of Medical Statistics and Epidemiology, Technical University of Munich, Germany) Microarray-Based Classiﬁ cation of Histopathologic Responder and Non-Responder Rectal Carcinomas to Neoadjuvant Radiochemotherapy Treatment 11:34 C-46-4 : Daniel Fischer(School of Health Sciences, University of Tampere, Finland) Generalized Mann-Whitney Type Tests for Detecting eQTL in Prostate Cancer 11:51 C-46-5 : Tatjana von Rosen(Department of Statistics, Stockholm University, Sweden) Multivariate Analysis of Fractal Dimension with Applications to EEG Data 12:08 C-46-6 : James J. Chen (National Center for Toxicological Research US Food and Drug Administration, USA) Identiﬁ cation of Bicluster Regions with Application to FDA's Drug Safety Data

11:00 Contributed 47 : Mixed/Random Effects Model #503 Chair : Geert Verbeke(Katholieke Universiteit Leuven, Belguim) + #504 11:00 C-47-1 : Alex R. de Leon(Department of Mathematics & Statistics, University of Calgary, Canada) Flexible Random Effects Copula Models for Clustered Mixed Bivariate Outcomes 11:17 C-47-7 : Freedom Gumedze(Department of Statistical Sciences, University of Cape Town, South Africa) Detection and Downweighting of Outlying Subjects in Random Coefﬁ cient Models Using a Variance Shift Outlier Model 11:34 C-47-3 : Selçuk Korkmaz(Biostatistics and Medical Informatics, Trakya University, Turkey) The Use of Nonlinear Mixed Effects Models in Bioequivalence Studies: A Real Data Application 11:51 C-47-4 : Ikuko Funatogawa(Department of Public Health, Teikyo University School of Public Health, Japan) Dose-Response Relationship from Longitudinal Data with Response-Dependent Dose-Modiﬁ cation Using Likelihood Method 12:08 C-47-5 : Masaru Kanba(Biostatistics Department, Shionogi & Co., Ltd., Japan) Comparison of Performance between Penalized Spline and MMRM for Longitudinal Clinical Trial Data 12:25 C-47-6 : Paulo J. Ribeiro Jr(LEG/DEST – Paraná Federal University, Brazil) Beta Mixed Models with Applications to the Analysis of Indexes

44 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

31 August (Friday): 14:00-15:45 14:00 Invited Session 14 : Statistical Methods for Analyzing Neurophysiological Signals International Organisers : Mark Fiecas(Brown University, USA), conference Sati Mazumdar(University of Pittsburgh,USA) room Chair : Sati Mazumdar 14:00 I-14-1 : Mohammad Hasan Machfoed(Airlangga University School of Medicine, Indonesia) MRI Features of Ischemic Stroke: Correlation between Lesion Volume and Neurological Status 14:25 I-14-2 : Michael Eichler(Maastricht University, The Netherlands) Spatial Identiﬁ cation of Epilepsy Regions 14:50 I-14-3 : Mark Fiecas(Brown University, USA) Modeling an Evolving Evolutionary Spectra 15:15 I-14-4 : John Aston(University of Warwick, UK) Can a Functional Data Approach Help with Quantiﬁ cation in Positron Emission Tomography? 15:40 General Discussion and Questions

14:00 Contributed 48 : Modeling and Analysis of Clinical Research Data #501 Chair : Ruth M. Pickering(University of Southampton, UK) 14:00 C-48-1 : Jane Temple(Mathematical Scien, University of Bath, UK) Direct Sampling from the Posterior Distribution for Non-Linear Dose Response Models 14:17 C-48-3 : Hideaki Uehara(International Pharmaceutical Development, Sales and Marketing Division, Tsumura and Co., Japan) Mixture Models for Epileptic Seizure Counts 14:34 C-48-4 : Ruth M. Pickering(Public Health Sciences and Medical Statistics, University of Southampton, UK) A Log Linear Model for Reported Exercises Completed of Those Prescribed by a Physiotherapist 14:51 C-48-5 : Kanae Togo(Clinical Statistics, Pﬁ zer Japan Inc., Japan) Group Comparisons Involving Zero-Inﬂ ated Count Data in Clinical Trials 15:08 C-48-6 : Fanghong Zhang(Department of Biomedical Data Sciences, GlaxoSmithKline K. K., Japan) A Note of Non-Inferiority Testing for Exponential Family Models 17:06 C-48-7 : Motoki Oe(Clinical Development Department, Otsuka Pharmaceutical Factory, Inc., Japan) Smoothing Receiver Operating Characteristic Curve

14:00 Contributed 49 : Survival Analysis: Modeling (2) #502 Chair : Satoshi Teramukai(Kyoto University Hospital, Japan) 14:00 C-49-1 : Morten Valberg(Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Norway) Frailty Modeling of Age-Incidence Curves of Osteosarcoma and Ewing Sarcoma among Individuals Younger than 40 Years 14:17 C-49-2 : Willy Wynant(Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada) Spline-Based Estimation of Survival Curves in a Flexible Model with Non-Linear Effects and Time-Dependent Effects/Covariates 14:34 C-49-3 : Birgitt Wiese(Hannover Medical School, Institute of Biometrics, Germany) Tree-Structured Survival Analysis with Time Dependent Covariates 14:51 C-49-4 : Takahiro Hasegawa(Biostatistics Department, Shionogi & Co.,Ltd., Japan) Estimation of Delayed Onset Time Assuming Piecewise Exponential Distribution in Cancer Vaccine Studies

14:00 Contributed 50 : Mixed Effects Model and Reliability of Diagnosis #401 Chair : Isao Yoshimura(Nagoya, Japan) + #402 14:00 C-50-1 : Shuhei Mano(Mathematical Analysis and Statistical Inference, Institute of Statistical Mathematics, Japan) Random Effects in Measurement of Radiation Exposure by Biodosimetry 14:17 C-50-2 : Timothy W. Waite(Southampton Statistical Sciences Research Institute, University of Southampton, UK) Designs Taking into Account Individual Variation in Dose-Response Studies 14:34 C-50-5 : Hiroyuki Saeki(Development Department, FUJIFILM RI Pharma Co., Ltd.,/Graduate School of Science, Chiba University, Japan) A Test for the Difference in Correlated Proportions of Clustered Data based on Multiple Raters 14:51 C-50-6 : Yusuke Tsutsumi(Development Quality Management Department, Mitsubishi Tanabe Pharma Corporation, Japan) The Comparison between Intraclass Correlation Coefﬁ cients(ICC) and Concordance Correlation Coefﬁ cient(CCC) under the Heteroscedasticity

31 August (Friday): 16:15-17:15 16:15 Closing Session International conference room

45 XXVIth International Biometric Conference

International Biometric Conference 2012 Satellite Symposium Meta-analysis and Surrogate Endpoints in the Evaluation of Cancer Chemotherapy -Introduction of the GASTRIC project-

It is my pleasure to introduce the GASTRIC project and explain the method of the study in the evaluation of cancer chemotherapy with Dr. Marc Buyse and Dr. Tomasz Burzykonski who co-edited “The evaluation of Surrogate Endpoints (statistics for Biology and Health.)” Join us for the inspiring lectures from the forefront of the ﬁ eld. Yasuo OHASHI Professor, Department of Biostatistics, School of Public Health, the University of Tokyo Chairman, Japan Clinical Research Support Unit

Date: 31st, August, 2012 (Fri) 17:15-19:00 (open 16:30) Place: Kobe International Conference Center, Room 501 Address: 6-9-1 Minatojima-nakamati Chuo-ku Kobe 650-0046 Japan Contact number: +81-78-302-5200 Registration fee: 10,000 yen (JPY) (free for the participants of IBC Kobe 2012) Application in advance ・contact: FAX +81-3-3254-8037 (J-CRSU)

Programme Chair: Yasuo OHASHI (Professor, Department of Biostatistics, School of Public Health, the University of Tokyo)

Opening Remarks: Yasuo Ohashi 1. Xavier PAOLETTI (Biostatistical dpt. / INSERM U900 Curie Institute, Paris, France) - GASTRIC meta-analysis project: a Worldwide Collaboration for worldwide results 2. Marc BUYSE (Chairman of Consultancy Services at IDDI* and Associate Professor of Biostatistics, Hasselt University) * International Drug Development Institute - Contributions of meta-analyses based on individual patient data in cancer chemotherapy 3. Tomasz BURZYKOWSKI (Professor of Biostatistics/Bioinformatics at Hasselt University and Vice- President of Research, IDDI * ) - Statistical methodology to evaluate the surrogate endpoints in oncology 4. Koji OBA (Lecturer at Hokkaido University Hospital) - Network meta-analysis using individual patient data

Closing We are planning to invite registrants to a buffet party with speakers.

Organiser: Japan Clinical Research Support Unit (J-CRSU) Sponsors: Corporate sponsorships details to be ﬁ nalized

Secretariat: Administrative contact at J-CRSU Ｈ ideaki SUZUKI [email protected] Mitsuko MOURI [email protected] TEL +81-3-3254-8028 FAX +81-3-3254-8037

46 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

47 XXVIth International Biometric Conference

48 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

49 XXVIth International Biometric Conference

50 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society

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organized by the Biometric Society of Italy, Italian Region of the International Biometric Society Florence, July 6 -11.2014

ABOUT FLORENCE CONFERENCE ORGANIZATION Whether yours is a visit that allows for sightseeing or not you will not fail to Organizing President succumb to the timeless beauty of this city. Clarice Garcia Borges Demétrio, Universidade de São Paulo, Brasil Known as the city of art, Florence has a wealth of traditional craft workers International Programme Committee Chair producing some of the finest products including leather craft, gold craft, knitwear, Brian Cullis, University of Wollongong, Australia furniture and antiques. The famous designer shopping street is Via Tornabuoni and Local Organizing Committee Chair glancing across the shop windows you will find some of the most prestigious Italian Adriano Decarli, University of Milan, Italy designer names. SCIENTIFIC PROGRAMME ACCESS TO FLORENCE Florence is served by two main airports, Pisa Airport and the city airport of - Pre-conference short courses - Opening ceremony and IBS presedential address Full programme Peretola just 4 kilometres outside of the city centre. of invited oral There is direct rail link from Pisa airport to Florence, a 40 minute train journey, and - Sessions Contributed oral and poster sessions the central station of ‘Santa Maria Novella’ links Florence by rail directly to all the - Satellite Meetings main cities in Italy (Rome 280 Km - Milan 320 Km) and throughout Europe. SOCIAL PROGRAMMES ABOUT CONFERENCE VENUES Sunday 6 - Welcome gathering at Firenze Fiera Congress Center An exclusive area in one of the most beautiful places in the world - this is what the Monday 7 - Reception in Florence City Hall Firenze Fiera Congress & Exhibition Center offers to those who organise Tuesday 8 - Optional evening social activities exhibitions and congresses, as well as to the event attendees. Wednesday 9 - Social excursion The over 100,000 square metres available inside our center are actually located in Thursday 10 - Conference Dinner the heart of Florence, between the city historic centre and the boulevards, major traffic arteries built over the lay-out of the ancient city walls. ORGANIZING SECRETARIAT FASI S.r.l. Via R. Venuti 73 - 00162 Roma For further information: www.ibs-italy.info Tel: +39 06.97605610 | Fax: +39 06.97605650 [email protected] | www.fasiweb.com