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Sponsored by the International Biometric Society Sponsored by the International Biometric Society The International Biometric Society is devoted to the development and application of statistical and mathematical theory and methods in the biosiciences. The Conference is grateful for the support of the following organisations: The Federation of Pharmaceutical Manufacturers' Associations of JAPAN Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society Contents List of Sponsors Inside Front Cover Welcome from Presidents Page 2 Welcome from Chairs Page 3 Programme at a Glance Page 4 - 6 Opening Session Page 7 IBC2012 Governance Meetings Schedule Page 8 Organising Committees Page 9 Awards at IBC Kobe 2012 Page 10 General Information Page 11 Venue Information Page 12 Presentation Instruction Page 13 Social Programme Page 15 Mid-Conference Tours Page 16 Scientifi c Programme Page 21 Satellite Symposium Page 46 Map of KICC Page 60 Access Map Page 61 Floorplan Page 62 1 XXVIth International Biometric Conference Message from the IBS President and the IBC 2012 Organising President It is with great pleasure that we welcome all delegates, their families and friends to the XXVIth International Biometric Conference (IBC 2012) being hosted by the Japanese Region in Kobe. It is nearly thirty years since they hosted the one previous IBC held in Japan in Tokyo in 1984. Toshiro Tango and his Local Organising Committee (LOC) have done a wonderful job in providing a socially and scientifi cally inviting program at an outstanding venue. The Kobe International Convention Centre provides excellent spaces for formal meetings/scientifi c sessions and informal conversations/ networking activities which are an essential part of every IBC. The task of the LOC was made particularly diffi cult after the natural disaster which stuck northern Japan in early 2011. The Japanese Region very much appreciated the concern shown by members from around the world for their welfare under incredibly diffi cult conditions. The national recovery effort has been immense in both size and duration, so delegates are encouraged to visit other parts of Japan to show their support for these courageous people. Christine McLaren and her International Program Committee (IPC) have contributed to the scientific program by selecting 14 invited sessions which are spread throughout the week. We have also scheduled Biometrics and JABES Showcases, a Young Statisticians Showcase, a Special Invited Session from the ISI, and many sessions containing contributed talks. The end result is that members will have much choice in selecting talks and/or posters of interest to them. This is over and above Sunday’s workshops which were organised by the Education Committee. In addition to the above, we are grateful to the continued support of our Executive Director Dee Ann Walker and her colleagues at the IBS International Business Office in overseeing the submission of abstracts and helping us to manage the society is much appreciated. We are looking forward to renewing international friendships and professional contacts and making new ones during the next week. Hopefully, many of you will also join us in Florence Italy for the XXVIIth International Biometric Conference in 2014. We wish you all an enjoyable and productive time. Clarice G.B. Demétrio Kaye E. Basford President Organising President International Biometric Society IBC 2012 Kobe 2 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society Message from the Chair of the International Programme Committee Welcome to the XXVIth International Biometric Conference, the biennial meeting of the International Biometric Society. The scientifi c program consists of 14 invited sessions, fi ve special sessions, and over 40 contributed oral sessions. In addition, four short courses will be offered and scientifi c posters will be on display throughout the conference. We thank the International Business offi ce, the organizing President, Kaye Basford, and the President, Clarice Demetrio. In particular we would like to thank Yutaka Matsuyama, who worked with us to build the scientifi c program, and the Local Organizing Committee, who assumed responsibility for the fi nal program schedule and local infrastructure arrangements, under the leadership of Toshiro Tango. The meeting will be held at the Kobe International Conference Center. Kobe, located between the sea and the Rokko mountain range, is known as an attractive and cosmopolitan port city. We are grateful to our hosts, the Biometric Society of Japan and the Japanese Region of the IBS, for arranging this excellent venue that promises to encourage scientifi c, social, and cultural interchanges among our diverse membership. We welcome you to the meeting. Christine McLaren Chair, International Programme Committee Message from the Chair of the Local Organising Committee We are pleased to announce that the XXVIth IBC is to be held in Kobe, Japan as scheduled. After the unprecedented earthquake and tsunami followed by the nuclear plant accident in Fukushima, we have received many sincere condolences for Japanese people. First of all, we would like to express our heartfelt gratitude to you. We have received comments from colleagues overseas who are concerned about the safety of holding the Conference in Japan. However, Kobe is located more than 600 kilometers away from the affected area and so all is well and everything is functioning properly. The first IBC to take place in Asia was held in Tokyo in 1984 and the prosperity of this field has indeed been conspicuous since that event. We are confi dent that the XXVIth IBC will witness the passing of the baton from our illustrious predecessors to the next generation of researchers who will further advance our understanding of biometrics and extend their applications in related fi elds. As always, it will bring together participants from all over the world working in academic institutions, government agencies, and industry to exchange ideas on the latest advances in biometry, biostatistics and bioinformatics. It will also be an occasion to meet old and new friends, and the chance to visit historical cities such as Kobe, Kyoto and Nara. We are very much looking forward to seeing you all in Kobe! Toshiro Tango Chair, Local Organising Committee 3 XXVIth International Biometric Conference Programme at a Glance 26 August (Sunday) 27 August (Monday) 09:00 Short Course 09:00 Opening Session 10:30 Coffee Break 11:00 Scientifi c Session 1 Invited Session 1: Novel Statistical Methodology and Its Application in Marine Ecology and Fisheries Research Short Course 1: Group Sequential and Adaptive Contributed 1: Analysis and Interpretation of Clinical Methods for the Design of Clinical Trials Trial Data Contributed 2: Analysis of Medical/Clinical Data Contributed 3: Missing Data and Imputation Contributed 4: Distribution and Statistical Inference Short Course 2: Joint Modeling Approaches in 12:45 Lunch Longitudinal Studies Using Random Effects 14:00 Scientifi c Session 2 Invited Session 2: The Landmark Approach to Event History Analysis Invited Session 3: Statistical Challenges in the Analysis of Rare Genetic Variants in Association Studies Short Course 3: Clinical Trial Data Analysis Using R Contributed 5: Nested Case-Control Study Contributed 6: Pharmacokinetic and Pharmacodynamic Studies Contributed 7: Sampling Method Poster Presentation 1 Short Course 4: Identifying Genes for Complex and Mendelian Traits Using Next Generation Sequence Data 15:45 Coffee Break 16:15 Scientifi c Session 3 Biometrics Showcase Session Contributed 8: Cancer Clinical Trial Contributed 9: Longitudinal Data: Modeling Contributed 10: Analysis of Ecological Data (1) Lunch & Coffee Break during Sessions * Contributed 11: Categorical Data 17:00 Welcome Reception Poster Presentation 1 4 Organised by the Biometric Society of Japan, Japanese Region of the International Biometric Society 28 August (Tuesday) 29 August (Wednesday) 08:45 Scientifi c Session 4 Invited Session 4: Advances in Spatial Latent Variable Modeling with Applications to Bio-Sciences Contributed 12: Clinical Trials: Design Issues (1) Contributed 13: Analysis of Genetic Data (1): GWAS Contributed 14: Agriculture Research (1) Contributed 15: Multiple Testing Poster Presentation 2 10:30 Coffee Break 11:00 Scientifi c Session 5 Invited Session 5: New Developments in Statistical Ecology Contributed 16: Clinical Trials: Design Issues (2) Contributed 17: Analysis of Genetic Data (2) Contributed 18: Agriculture Research (2) Contributed 19: Classifi cation and Mixture Distribution Poster Presentation 2 12:45 Lunch 14:00 Scientifi c Session 6 Mid-Conference Tours Invited Session 6: Approximate Bayesian Computation (ABC) and Likelihood-Free Inference Invited Session 7: Novel Mixture Modeling and Likelihood Methods in Modern Biomedical Applications Contributed 20: Analysis of Genetic Data (3) Contributed 21: Causal Inference (1) Contributed 22: Analysis of Ecological Data (2) Poster Presentation 3 15:45 Coffee Break 16:15 Scientifi c Session 7 JABES Showcase Session Contributed 23: Meta-Analysis Contributed 24: Bayesian Modeling and Biological Network Contributed 25: Causal Inference (2) Contributed 26: Analysis of Ecological Data (3) and Saturation Mutagenesis Poster Presentation 3 18:15 IBS General Meeting and Awards Presentation 5 XXVIth International Biometric Conference 30 August (Thursday) 31 August (Friday) 08:45 Scientifi c Session 8 08:45 Scientifi c Session 12 Invited Session 8: HER Databases and Long Term Invited Session
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