(CANCER RESEARCH 58. 4480-4480, October 1. 1998] Letter to the Editor

Correspondence re: J. Benitez et al., A Region of Allelic Imbalance in lq31-32 in Primary Breast Cancer Coincides with a Recombination Hot Spot. Cancer Res., 57: 4217-4220, 1997

We would like to draw attention to information in Benitez et al. (1) D1S2527, D1S2816, D1S413, DÌS2622,DÌS2615,D1S477, D1S1723, presenting a 10-cM critical region of allelic imbalance in the chromo D1S2655, D1S2686, D1S2668, D1S2717, D1S2872, D1S249, and somal region lq31-32 proximal to the REN , flanked by the D1S2692) located between D1S1604 and DÌS237byPCR. In four MBs CACNLIA3 and D1S2655 markers, in >60% of 33 primary breast (cases D218II, D245II, D282, and D296), the common region of LOH tumors. Within the lq31-32 bands, two other regions of allelic imbalance included the marker D1SI 723, flanked by the markers DIS477 and have been described, one distal to the REN locus between D1S249 and DIS2655, although two MBs (cases D282 and D296) were not inform DÌS237in breast tumors (2), comparable to that found in renal duct ative at D1SÌ723(Fig.1). The critical region of allelic loss identified in carcinoma (3), and the other proximal to the REN locus between D1S65 these four MBs is consistent with and appears to further narrow down that and REN in breast tumors (4), which seems to overlap with the one described in male germ cell tumors (5). Recently, we described LOH' in described by Benitez et al. ( 1), supporting the suggestion of the presence of a tumor suppressor (s) involved in the pathogenesis of different the chromosomal region Iq31-32.1 flanked by the markers DIS1604 and types of tumors, including primary breast cancer and a subgroup of MBs. D1S237 in 8 of 22 human MBs (36%; Ref. 6). In these MBs, we tried to further narrow down the common region of overlap amplifying an addi JürgenA. Kraus tional 18 microsatellites (D1S238, D1S422, D1S2625, D1S412, Anke Koch Torsten Pietsch Department of Neuropathology Case University of Bonn Medical Center D218II D245II D282 D296 LOCUS D-53105 Bonn, Germany

D1S1604 D1S2622 References D1S2615 1. Benitez. J., Osorio, A., Barroso, A.. Arranz, E., Diaz-Guillen. M. A., Robledo, M., Rodríguez de Córdoba, S., and Heine-Suner, D. A region of allelic imbalance in lq D1S477 lq31-32 in primary breast cancer coincides with a recombination hot spot. Cancer Res., 57: 4217-4220, 1997. D1S1723 2. Hoggard, N., Brinmell, B., Howell, A., Weissenbach, J., and Varley, J. Allelic D1S2655 imbalance on 1 in human breast cancer. II. Microsatellite repeat anal ysis. Cancer, 12: 24-31, 1995. D1S2686 3. Steiner, G.. Carms. P.. Polaseik, T. J., Marshall. F. F., Epstein. J., Sidransky. D., and D1S237 Schoenberg, M. High density mapping of chromosomal arm lq in renal collecting duct carcinoma: region of minimal deletion at lq32.l-32.2. Cancer Res., 56: 5044- 5046. 1996. Fig. 1. Allelic loss on chromosome tq in MBs. •¿,LOH;O, maintenance of heterozy 4. Loupart, M. L., Armour, J., Walker, R., Adams, S.. Brammar. W., and Varley, J. gosity; O. non informali ve. Allelic imbalance on chromosome I in human breast cancer. I. Minisatellitc and RFLP analysis. Genes Chromosomes Cancer. 12: 16-23, 1995. 5. Mathew. S.. Murty. V. V., Bosl. G. J., and Chaganti, R. S. Loss of heterozygosity iilcni 11n."-multiple sites of allelic deletions on in human male germ cell tumors. Cancer Res., 54: 6265-6269, 1994. 6. Kraus, J. A., Koch, A.. Albrecht, S., von Deimling, A.. Wiestier. O. D., and Pietsch, Received 5/20/98; accepted 8/3/98. T. Loss of heterozygosily at locus F13B on chromosome lq in human medulloblas- 1The abbreviations used are: LOH, loss of helerozygosity; MB, medulloblastoma. toma. Int. J. Cancer, 67: 11-15, 1996.

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Downloaded from cancerres.aacrjournals.org on October 2, 2021. © 1998 American Association for Cancer Research. Correspondence re: J. Benítez et al., A Region of Allelic Imbalance in 1q31−32 in Primary Breast Cancer Coincides with a Recombination Hot Spot. Cancer Res., 57: 4217−4220, 1997

Jürgen A. Kraus, Anke Koch and Torsten Pietsch

Cancer Res 1998;58:4480.

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