Anti-PSCA (Extracellular Domain) Polyclonal Antibody (DPAB1998RH) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Total Page：16

File Type：pdf, Size：1020Kb

Anti-PSCA (extracellular domain) polyclonal antibody (DPAB1998RH) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Rabbit anti-human prostate stem cell antigen polyclonal antibody is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of st Antigen Description Prostate stem cell antigen is a protein that in humans is encoded by the PSCA gene. This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon. Specificity This antibody reacts with a ~14 kD protein. Prostate Stem Cell Antigen (PSCA) is a cell surface antigen which is overexpressed in ~ 40% of primary prostate cancers and in nearly 100% of metastatic cancers. PSCA is also overexpressed in the majority of tra Immunogen A synthetic peptide derived from extracellular region of human PSCA protein. Isotype IgG Source/Host Rabbit Species Reactivity Human Conjugate Unconjugated Applications IHC Cellular Localization Cell membrane, cytoplasmic Positive Control Bladder carcinoma, prostate carcinoma Format Purified immunoglobulin fraction of rabbit antiserum against PSCA containing sodium azide as a preservative. Preservative See individual product datasheet Storage Store at 2-8℃. Do not use beyond the expiration date stated on the label. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name PSCA prostate stem cell antigen [ Homo sapiens ] Synonyms PSCA; PRO232; prostate stem cell antigen; prostate stem cell antigen; OTTHUMP00000221185 Entrez Gene ID 8000 Protein Refseq NP_005663 UniProt ID D3DWI6 Chromosome Location 8q24.2 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

Copy Link

Recommended publications

Association of MUC1 5640G>A and PSCA 5057C>T Polymorphisms
Alikhani et al. BMC Medical Genetics (2020) 21:148 https://doi.org/10.1186/s12881-020-01085-z RESEARCH ARTICLE Open Access Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran Reza Alikhani1, Ali Taravati1 and Mohammad Bagher Hashemi-Soteh2* Abstract Background: Gastric cancer is one of the four most common cancer that causing death worldwide. Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was avaluating the association of rs4072037G > A polymorphism in MUC1 and rs2294008 C > T in PSCA gene with risk of gastric cancer in northern Iran. Methods: DNA was extracted from 99 formalin fixed paraffin-embedded (FFPE) tissue samples of gastric cancer and 96 peripheral blood samples from healthy individuals (sex matched) as controls. Two desired polymorphisms, 5640G > A and 5057C > T for MUC1 and PSCA genes were genotyped using PCR-RFLP method. Results: The G allele at rs4072037 of MUC1 gene was associated with a significant decreased gastric cancer risk (OR = 0.507, 95% CI: 0.322–0.799, p = 0.003). A significant decreased risk of gastric cancer was observed in people with either AG vs. AA, AG + AA vs. GG and AA+GG vs. AG genotypes of MUC1 polymorphism (OR = 4.296, 95% CI: 1.190–15.517, p =0.026), (OR = 3.726, 95% CI: 2.033–6.830, p = 0.0001) and (OR = 0.223, 95% CI: 0.120–0.413, p = 0.0001) respectively.
[Show full text]
Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population
pISSN 1598-2998, eISSN 2005-9256 Cancer Res Treat. 2019;51(2):748-757 https://doi.org/10.4143/crt.2018.162 Original Article Open Access Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population Boyoung Park, MD, PhD1,2 Purpose Sarah Yang, PhD3,4 Half of the world’s gastric cancer cases and the highest gastric cancer mortality rates are observed in Eastern Asia. Although several genome-wide association studies (GWASs) have Jeonghee Lee, MS3 revealed susceptibility genes associated with gastric cancer, no GWASs have been con- PhD3 Hae Dong Woo, ducted in the Korean population, which has the highest incidence of gastric cancer. Il Ju Choi, MD, PhD5 Young Woo Kim, MD, PhD5 Materials and Methods Keun Won Ryu, MD, PhD5 We performed genome scanning of 450 gastric cancer cases and 1,134 controls via Affymetrix Axiom Exome 319 arrays, followed by replication of 803 gastric cancer cases and Young-Il Kim, MD, PhD5 3,693 healthy controls. Jeongseon Kim, PhD2,3 Results We showed that the rs2976394 in the prostate stem cell antigen (PSCA) gene is a gastric- 1Department of Medicine, Hanyang cancer-susceptibility gene in a Korean population, with genome-wide significance and an University College of Medicine, Seoul, odds ratio (OR) of 0.70 (95% confidence interval [CI], 0.64 to 0.77). A strong linkage dise- 2 Graduate School of Cancer Science and quilibrium with rs2294008 was also found, indicating an association with susceptibility. Policy, National Cancer Center, Goyang, 3Molecular Epidemiology Branch, Division of Individuals with the CC genotype of the PSCA gene showed an approximately 2-fold lower Cancer Epidemiology and Prevention, risk of gastric cancer compared to those with the TT genotype (OR, 0.47; 95% CI, 0.39 to Research Institute, National Cancer Center, 0.57).
[Show full text]
Prostate Stem Cell Antigen Is Expressed in Normal and Malignant Human Brain Tissues
ONCOLOGY LETTERS 15: 3081-3084, 2018 Prostate stem cell antigen is expressed in normal and malignant human brain tissues HIROE ONO, HIROMI SAKAMOTO, TERUHIKO YOSHIDA and NORIHISA SAEKI Division of Genetics, National Cancer Center Research Institute, Tokyo 104-0045, Japan Received June 25, 2015; Accepted October 24, 2016 DOI: 10.3892/ol.2017.7632 Abstract. Prostate stem cell antigen (PSCA) is a glyco- functions in subcellular signal transduction (2). Originally, sylphosphatidylinositol (GPI)-anchored cell surface protein PSCA was identified as a gene upregulated in prostate cancer (3), and exhibits an organ-dependent expression pattern in cancer. and later its upregulation was demonstrated in other types of PSCA is upregulated in prostate cancer and downregulated in tumor, including urinary bladder cancer, renal cell carcinoma, gastric cancer. PSCA is expressed in a variety of human organs. hydatidiform mole and ovarian mucinous tumor, where PSCA is Although certain studies previously demonstrated its expres- thought to be involved in tumor progression (1). However, down- sion in the mammalian and avian brain, its expression in the regulation of the gene was reported in gastric and gallbladder human brain has not been thoroughly elucidated. Additionally, cancer, where it may act as a tumor suppressor (4,5). As another it was previously reported that PSCA is weakly expressed in the pattern of its expression in cancer, PSCA is not expressed in the astrocytes of the normal human brain but aberrantly expressed ductal cells of the normal pancreas or the epithelial cells in the in glioma, suggesting that PSCA is a promising target of normal lung, however, it is expressed in their malignant coun- glioma therapy and prostate cancer therapy.
[Show full text]
Organization, Evolution and Functions of the Human and Mouse Ly6/Upar Family Genes Chelsea L
Loughner et al. Human Genomics (2016) 10:10 DOI 10.1186/s40246-016-0074-2 GENE FAMILY UPDATE Open Access Organization, evolution and functions of the human and mouse Ly6/uPAR family genes Chelsea L. Loughner1, Elspeth A. Bruford2, Monica S. McAndrews3, Emili E. Delp1, Sudha Swamynathan1 and Shivalingappa K. Swamynathan1,4,5,6,7* Abstract Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members. Keywords: Ly6/uPAR family, LU domain, Three-finger domain, uPAR, Lymphocytes, Neutrophils Introduction an overview of the Ly6/uPAR gene family and their gen- The lymphocyte antigen-6 (Ly6)/urokinase-type plas- omic organization, evolution, as well as functions, and minogen activator receptor (uPAR) superfamily of struc- provide a nomenclature system for the newly identified turally related proteins is characterized by the LU members of this family.
[Show full text]
Prostate Stem Cell Antigen (PSCA) Variants and Subsequences Thereof
(19) TZZ ¥_ _T (11) EP 2 319 524 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: A61K 38/00 (2006.01) C07K 14/00 (2006.01) of the grant of the patent: C07K 16/00 (2006.01) G01N 33/532 (2006.01) 21.08.2013 Bulletin 2013/34 G01N 33/574 (2006.01) (21) Application number: 11152953.3 (22) Date of filing: 28.05.2004 (54) Prostate stem cell antigen (PSCA) variants and subsequences thereof Prostatstammzellenantigen-Varianten und Untersequenzen davon Variantes de l’antigène de cellules souches de la prostate (PSCA) et sous-séquences de celles-ci (84) Designated Contracting States: • Raitano, Arthur B. AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Los Angeles, CA 90066 (US) HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: (74) Representative: Lord, Hilton David AL HR LT LV MK Marks & Clerk LLP 90 Long Acre (30) Priority: 30.05.2003 US 475064 P London WC2E 9RA (GB) (43) Date of publication of application: 11.05.2011 Bulletin 2011/19 (56) References cited: WO-A-01/40309 WO-A-98/40403 (62) Document number(s) of the earlier application(s) in WO-A1-01/04311 US-A1- 2002 102 666 accordance with Art. 76 EPC: 04785910.3 / 1 629 088 • GU Z ET AL: "MONOCLONAL ANTIBODIES AGAINST PROSTATE STEM CELL ANTIGEN (73) Proprietor: Agensys, Inc. (PSCA) DETECT HIGH LEVELS OF PSCA Santa Monica CA 90404 (US) EXPRESSION IN PROSTATE CANCER BONE METASTATES", JOURNAL OF UROLOGY, (72) Inventors: LIPPINCOTT WILLIAMS & WILKINS, • Jakobovits, Aya BALTIMORE, MD, US, vol.
[Show full text]
Prostate Stem Cell Antigen Gene Is Expressed in Islets of Pancreas
Original Article http://dx.doi.org/10.5115/acb.2012.45.3.149 pISSN 2093-3665 eISSN 2093-3673 Prostate stem cell antigen gene is expressed in islets of pancreas Hiroe Ono*, Kazuyoshi Yanagihara, Hiromi Sakamoto, Teruhiko Yoshida, Norihisa Saeki Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan Abstract: Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored cell surface antigen with an organ- dependent expression pattern in cancers; e.g., up-regulated in prostate cancer and down-regulated in gastric cancer. Previously it was reported that PSCA is not expressed in the normal pancreas but aberrantly expressed in pancreatic cancer. In this present study, we identified PSCA expression in islets of the pancreas by immunohistochemistry, which was co-localized with four islet- cell markers: insulin, glucagon, somatostatin and pancreatic polypeptide. In our investigation of the transcription start site of PSCA, we found a non-coding splicing variant of PSCA as well as authentic PSCA transcripts in mRNA samples from a normal pancreas. Both the transcripts were also identified in several pancreatic cancer cell lines. We previously reported that PSCA expression is correlated to the methylation status of the enhancer region in gastric and gallbladder cancer cell lines but not in pancreatic cancer cell lines, suggesting that PSCA expression is regulated in a different mode in pancreatic cancer from that in gastric and gallbladder cancers. Key words: GPI-anchored protein, Islet cells, Pancreatic cancer, Splicing variant, Immunohistochemistry Received June 19, 2012; Revised July 19, 2012; Accepted August 14, 2012 Introduction [3]. It is also up-regulated in other tumors including urinary bladder cancer, renal cell carcinoma, hydatidiform mole and The prostate stem cell antigen (PSCA) gene encodes a ovarian mucinous tumor, where PSCA is thought to abet glycosylphosphatidylinositol (GPI)-anchored membrane tumor progression [1].
[Show full text]
NIH Public Access Author Manuscript Gastroenterology
NIH Public Access Author Manuscript Gastroenterology. Author manuscript; available in PMC 2012 February 1. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Gastroenterology. 2011 February ; 140(2): 435±441. doi:10.1053/j.gastro.2010.11.001. An association between a variation in the PSCA gene and upper gastrointestinal cancer in Caucasians Paul Lochhead*,1, Bernd Frank‡,1, Georgina L. Hold*, Charles S. Rabkin§, Michael T. H. Ng*, Thomas L. Vaughan∥, Harvey A. Risch¶, Marilie D. Gammon#, Jolanta Lissowska**, Melanie N. Weck‡, Elke Raum‡, Heiko Müller‡, Thomas Illig‡‡, Norman Klopp‡‡, Alan Dawson*, Kenneth E. McColl§§, Hermann Brenner‡, Wong-Ho Chow§, and Emad M. El- Omar* *Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Scotland ‡Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany §Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland ∥Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington ¶Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut #Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina **Division of Cancer Epidemiology and Prevention, M. Sklodowska- Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland ‡‡Institute of Epidemiology, Research Centre for Environment and Health, Neuherberg, Germany §§Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland Abstract Background & Aims—An association between gastric cancer and the rs2294008 (C>T) polymorphism in the prostate stem cell antigen (PSCA) gene has been reported for several Asian populations.
[Show full text]
High Mrna Expression of LY6 Gene Family Is Associated with Overall Survival Outcome in Pancreatic Ductal Adenocarcinoma
www.oncotarget.com Oncotarget, 2021, Vol. 12, (No. 3), pp: 145-159 Research Paper High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Eric Russ1, Krithika Bhuvaneshwar2, Guisong Wang3,4, Benjamin Jin1,4, Michele M. Gage3,5, Subha Madhavan2, Yuriy Gusev2 and Geeta Upadhyay1,3 1Department of Pathology, Uniformed Services University, Bethesda, MD, USA 2Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington DC, USA 3Murtha Cancer Center/Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 4The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, MD, USA 5Walter Reed Navy Military Medical Center, Department of Surgery, Uniformed Services University, Bethesda, MD, USA Correspondence to: Geeta Upadhyay, email: [email protected] Keywords: LY6 genes; pancreatic cancer; immune cells; survival outcome Received: November 21, 2020 Accepted: January 19, 2021 Published: February 02, 2021 Copyright: © 2021 Russ et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Pancreatic cancer ranks one of the worst in overall survival outcome with a 5 year survival rate being less than 10%. Pancreatic cancer faces unique challenges in its diagnosis and treatment, such as the lack of clinically validated biomarkers and the immensely immunosuppressive tumor microenvironment. Recently, the LY6 gene family has received increasing attention for its multi-faceted roles in cancer development, stem cell maintenance, immunomodulation, and association with more aggressive and hard-to-treat cancers.
[Show full text]
393LN V 393P 344SQ V 393P Probe Set Entrez Gene
393LN v 393P 344SQ v 393P Entrez fold fold probe set Gene Gene Symbol Gene cluster Gene Title p-value change p-value change chemokine (C-C motif) ligand 21b /// chemokine (C-C motif) ligand 21a /// chemokine (C-C motif) ligand 21c 1419426_s_at 18829 /// Ccl21b /// Ccl2 1 - up 393 LN only (leucine) 0.0047 9.199837 0.45212 6.847887 nuclear factor of activated T-cells, cytoplasmic, calcineurin- 1447085_s_at 18018 Nfatc1 1 - up 393 LN only dependent 1 0.009048 12.065 0.13718 4.81 RIKEN cDNA 1453647_at 78668 9530059J11Rik1 - up 393 LN only 9530059J11 gene 0.002208 5.482897 0.27642 3.45171 transient receptor potential cation channel, subfamily 1457164_at 277328 Trpa1 1 - up 393 LN only A, member 1 0.000111 9.180344 0.01771 3.048114 regulating synaptic membrane 1422809_at 116838 Rims2 1 - up 393 LN only exocytosis 2 0.001891 8.560424 0.13159 2.980501 glial cell line derived neurotrophic factor family receptor alpha 1433716_x_at 14586 Gfra2 1 - up 393 LN only 2 0.006868 30.88736 0.01066 2.811211 1446936_at --- --- 1 - up 393 LN only --- 0.007695 6.373955 0.11733 2.480287 zinc finger protein 1438742_at 320683 Zfp629 1 - up 393 LN only 629 0.002644 5.231855 0.38124 2.377016 phospholipase A2, 1426019_at 18786 Plaa 1 - up 393 LN only activating protein 0.008657 6.2364 0.12336 2.262117 1445314_at 14009 Etv1 1 - up 393 LN only ets variant gene 1 0.007224 3.643646 0.36434 2.01989 ciliary rootlet coiled- 1427338_at 230872 Crocc 1 - up 393 LN only coil, rootletin 0.002482 7.783242 0.49977 1.794171 expressed sequence 1436585_at 99463 BB182297 1 - up 393
[Show full text]
PSCA Expression Is Associated with Favorable Tumor Features And
Heinrich et al. BMC Cancer (2018) 18:612 https://doi.org/10.1186/s12885-018-4547-7 RESEARCHARTICLE Open Access PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer Marie-Christine Heinrich1†, Cosima Göbel1†, Martina Kluth1, Christian Bernreuther2, Charlotte Sauer1, Cornelia Schroeder3, Christina Möller-Koop1, Claudia Hube-Magg1, Patrick Lebok1, Eike Burandt1, Guido Sauter1, Ronald Simon1* , Hartwig Huland4, Markus Graefen4, Hans Heinzer4, Thorsten Schlomm4,5 and Asmus Heumann3 Abstract Background: Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear. Methods: To clarify contradictory findings on the prognostic role of PSCA expression, a tissue microarray containing 13,665 prostate cancers was analyzed by immunohistochemistry. Results: PSCA staining was absent in normal epithelial and stromal cells of the prostate. Membranous and cytoplasmic PSCA staining was seen in 53.7% of 9642 interpretable tumors. Staining was weak in 22.4%, moderate in 24.5% and strong in 6.8% of tumors. PSCA expression was associated with favorable pathological and clinical tumor features: Early pathological tumor stage (p < 0.0001), low Gleason grade (p < 0.0001), absence of lymph node metastasis (p < 0.0001), low pre-operative PSA level (p = 0.0118), negative surgical margin (p < 0.0001) and reduced PSA recurrence (p < 0.0001). PSCA expression was an independent predictor of prognosis in multivariate analysis (hazard ratio 0.84, p < 0.0001). Conclusions: The absence of statistical relationship to TMPRSS2:ERG fusion status, chromosomal deletion or high tumor cell proliferation argues against a major role of PSCA for regulation of cell cycle or genomic integrity.
[Show full text]
Mouse Psca Conditional Knockout Project (CRISPR/Cas9)
https://www.alphaknockout.com Mouse Psca Conditional Knockout Project (CRISPR/Cas9) Objective: To create a Psca conditional knockout Mouse model (C57BL/6J) by CRISPR/Cas-mediated genome engineering. Strategy summary: The Psca gene (NCBI Reference Sequence: NM_028216 ; Ensembl: ENSMUSG00000022598 ) is located on Mouse chromosome 15. 3 exons are identified, with the ATG start codon in exon 1 and the TAG stop codon in exon 3 (Transcript: ENSMUST00000023265). Exon 2~3 will be selected as conditional knockout region (cKO region). Deletion of this region should result in the loss of function of the Mouse Psca gene. To engineer the targeting vector, homologous arms and cKO region will be generated by PCR using BAC clone RP23-429N15 as template. Cas9, gRNA and targeting vector will be co-injected into fertilized eggs for cKO Mouse production. The pups will be genotyped by PCR followed by sequencing analysis. Note: Homozygous null mice are viable and fertile and show no significant differences in spontaneous or radiation- induced primary epithelial tumor formation relative to wild-type littermates. Exon 2~3 covers 85.91% of the coding region. Start codon is in exon 1, and stop codon is in exon 3. The size of intron 1 for 5'-loxP site insertion: 1114 bp. The size of effective cKO region: ~1799 bp. The cKO region does not have any other known gene. Page 1 of 7 https://www.alphaknockout.com Overview of the Targeting Strategy Wildtype allele 5' gRNA region gRNA region 3' 1 2 3 Targeting vector Targeted allele Constitutive KO allele (After Cre recombination) Legends Homology arm Exon of mouse Psca cKO region loxP site Page 2 of 7 https://www.alphaknockout.com Overview of the Dot Plot Window size: 10 bp Forward Reverse Complement Sequence 12 Note: The sequence of homologous arms and cKO region is aligned with itself to determine if there are tandem repeats.
[Show full text]
Common Genetic Variants in the PSCA Gene in Fluence Gene Expression
Common genetic variants in the PSCA gene inﬂuence gene expression and bladder cancer risk Yi-Ping Fua, Indu Kohaara, Nathaniel Rothmanb, Julie Earlc, Jonine D. Figueroab, Yuanqing Yed, Núria Malatse, Wei Tanga, Luyang Liua, Montserrat Garcia-Closasb,f, Brian Muchmorea, Nilanjan Chatterjeeb, McAnthony Tarwaya, Manolis Kogevinasg,h,i,j, Patricia Porter-Gilla, Dalsu Barisb, Adam Mumya, Demetrius Albanesb, Mark P. Purdueb, Amy Hutchinsonk, Alfredo Carratol, Adonina Tardónh,m, Consol Serran, Reina García-Closaso, Josep Lloretap, Alison Johnsonq, Molly Schwennr, Margaret R. Karagass, Alan Schneds, W. Ryan Divert, Susan M. Gapsturt, Michael J. Thunt, Jarmo Virtamou, Stephen J. Chanocka, Joseph F. Fraumeni, Jr.b,1, Debra T. Silvermanb, Xifeng Wud, Francisco X. Realc,n, and Ludmila Prokunina-Olssona,1 aLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, and bDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; cEpithelial Carcinogenesis Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid 28029, Spain; dDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030; eGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Center, Madrid 28029, Spain; fDivision of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, United Kingdom; gCentre for Research in Environmental Epidemiology, Barcelona 08003, Spain; hMunicipal Institute of Medical
[Show full text]