Anti-PSCA (Extracellular Domain) Polyclonal Antibody (DPAB1998RH) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-PSCA (extracellular domain) polyclonal antibody (DPAB1998RH) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit anti-human prostate stem cell antigen polyclonal antibody is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of st

Antigen Description Prostate stem cell antigen is a protein that in humans is encoded by the PSCA gene. This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon.

Specificity This antibody reacts with a ~14 kD protein. Prostate Stem Cell Antigen (PSCA) is a cell surface antigen which is overexpressed in ~ 40% of primary prostate cancers and in nearly 100% of metastatic cancers. PSCA is also overexpressed in the majority of tra

Immunogen A synthetic peptide derived from extracellular region of human PSCA protein.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Conjugate Unconjugated

Applications IHC

Cellular Localization Cell membrane, cytoplasmic

Positive Control Bladder carcinoma, prostate carcinoma

Format Purified immunoglobulin fraction of rabbit antiserum against PSCA containing sodium azide as a preservative.

Preservative See individual product datasheet

Storage Store at 2-8℃. Do not use beyond the expiration date stated on the label.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name PSCA prostate stem cell antigen [ Homo sapiens ]

Synonyms PSCA; PRO232; prostate stem cell antigen; prostate stem cell antigen; OTTHUMP00000221185

Entrez Gene ID 8000

Protein Refseq NP_005663

UniProt ID D3DWI6

Chromosome Location 8q24.2

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]