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Astrazeneca Deals – Key Highlights

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Astrazeneca Deals – Key Highlights COMPANY OVERVIEW NOVEMBER 2020 NASDAQ: IPHA EURONEXT PARIS: IPH Forward Looking Statements This document has been prepared by Innate Pharma S.A. (the “Company”) solely for This presentation discusses product candidates that are under clinical development the purposes of a presentation to investors concerning the Company. This document and which have not yet been approved for marketing by the U.S. Food and Drug is not to be reproduced by any person, nor to be distributed. Administration or the European Medicines Agency. No representation is made as to the safety or effectiveness of these product candidates for the use for which such This document contains forward-looking statements. The use of certain words, product candidates are being studied. including “believe,” “potential,” “expect” and “will” and similar expressions, is intended to identify forward-looking statements. Although the Company believes its The information contained herein has not been independently verified. No expectations are based on reasonable assumptions, these forward-looking representation, warranty or undertaking, express or implied, is made as to, and no statements are subject to various risks and uncertainties, which could cause the reliance should be placed on, the fairness, accuracy, completeness or correctness of Company’s actual results or financial condition to differ materially from those the information or opinions contained herein. The Company is under no obligation to anticipated. These risks and uncertainties include, among other things, the keep current the information contained in this presentation and any opinion uncertainties inherent in research and development, including related to safety, expressed is subject to change without notice. progression of and results from its ongoing and planned clinical trials and preclinical The Company shall not bear any liability whatsoever for any loss arising from any use studies, review and approvals by regulatory authorities of its product candidates, the of this document or its contents or otherwise arising in connection therewith. Company’s commercialization efforts and the Company’s continued ability to raise capital to fund its development. For an additional discussion of risks and This document and the information contained herein do not constitute an offer to sell uncertainties which could cause the Company's actual results, financial condition, or a solicitation of an offer to buy or subscribe to shares of the Company in any performance or achievements to differ from those contained in the forward-looking country. statements, please refer to the Risk Factors (“Facteurs de Risque”) section of the Universal Registration Document filed with the Autorité des Marchés Financiers (“AMF”), available on the AMF website (www.amf-france.org) or on the Company’s website (www.innate-pharma.com), and public filings and reports filed with the U.S. Securities and Exchange Commission (“SEC”), including the Company’s Annual Report on Form 20-F for the year ended December 31, 2019, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public, by the Company. Such documents may not be necessarily up to date. This document contains data pertaining to the Company's potential markets and the industry and environment in which it operates. Some of this data comes from external sources that are recognized in the field or from Company’s estimates based on such sources. 2 Investment Highlights Lacutamab: EMA PRIME and FDA Fast Track designations in R/R Sézary syndrome; Phase 2 Broad and ongoing in SS and mycosis fungoides; potential to serve as pivotal study in SS Diversified Monalizumab: First patient dosed in Phase 3 R/M SCCHN trial, triggering $50 million milestone* Portfolio at Avdoralimab: novel approach by targeting C5aR; potential in inflammatory diseases Various Stages of Development Broad, early stage pipeline of innovative immunotherapies targeting innate immunity pathways Key clinical milestones across multiple programs over the next 12 to 18 months Transitioning to a • Lumoxiti: EU regulatory decision on track Commercial Stage Biotech • Lacutamab: could synergize with Innate’s commercial organization; potential for broader expansion Validating collaborations, including AstraZeneca and Sanofi Strong Financial Proven track record of execution across R&D, strategic partnering, and licensing agreements Base and Strategic Flexibility Cash, cash equivalents and financial assets of €163.6 million as of Sept 30, 2020 expected to cover financing needs through 2022 *not included in Q3 cash number 3 Our Strategy We strive to achieve scientific leadership in immunotherapy by leveraging our expertise in innate immunity and transition to a commercial stage biotech Science Commercial Finance • Deliver the current • Further shape commercial • Continue to pipeline & prepare competencies for Lumoxiti strengthen financial Innate’s future science and future commercial position to invest in products our portfolio 4 Innovative Approach to Immuno-Oncology Three-prong approach to harness the potential of the innate immune system Immune Checkpoint Tumor Antigen Tumor Micro Inhibitor Targeting Environment Unleash Target Relieve Endogenous Immune Killing Tumor cells Immune Suppression 5 Three Key Strategic Pillars to Harness the Potential of the Immune System Phase of Development Program Target Indication PC Ph 1 Ph 2 Ph 3 Commercial Partner SCCHN Monalizumab NKG2A Advanced Solid Tumors, Phase 1/2 including CRC Anti-Siglec-9 Siglec-9 Cancer Inhibitors (ICI) Inhibitors IPH25 Undisclosed Cancer Immune Checkpoint Checkpoint Immune Lumoxiti CD22 Hairy Cell Leukemia FDA Approved – Lacutamab Sézary Syndrome – KIR3DL2 (IPH4102) MF – IPH61 Undisclosed Cancer (TAG) (NKp46 NKCE) IPH43 MICA/B Cancer IPH62 Tumor Antigen Targeting Antigen Tumor Undisclosed Cancer (NKp46 NKCE) ) Avdoralimab CSU, BP – - C5aR (IPH5401) COVID-19 – IPH5201 CD39 Cancer Tumor Micro Tumor IPH5301 CD73 Cancer – environment (TME environment 6 Note: “SCCHN” Squamous Cell Carcinoma of the Head and Neck; “CRC” Colorectal Cancer; “MF” Mycosis Fungoides; “PTCL” Peripheral T-cell Lymphomas; “NSCLC” Non-Small Cell Lung Cancer; and “HCC” Hepatocellular Carcinoma. MONALIZUMAB FIRST-IN-CLASS ANTI-NKG2A MAB Monalizumab First-in-Class Anti-NKG2A mAb Promotes anti-tumor immunity by unleashing both T & NK cells Source: André, Vivier et al., Cell 2018 8 Monalizumab Lead Partnered Asset in Phase 3 Phase 3 study in patients with IO pre-treated SCCHN • First patient dosed in Phase 3 study in October 2020 o Monalizumab + cetuximab in IO-pretreated R/M Phase 2 Expansion Cohort 2 squamous cell carcinoma of the head and neck (SCCHN), Monalizumab + cetuximab, IO Pretreated R/M SCCHN** INTERLINK-1 o Study represents first Phase 3 study examining IO • ASCO20 data confirm prior observations of safety and approach in R/M SCCHN patients who have been treated ORR with a platinum-based therapy and PD-(L)1 inhibitor • Updated data will be presented at ESMO Immuno- • $50m milestone triggered* Oncology Virtual Congress in December o $400m from AstraZeneca for monalizumab since signing of the agreement Phase 2 Expansion Cohort 3 o Additional $50m milestone payment after the interim Mona + cetuximab + durvalumab, IO-Naïve R/M SCCHN*** analysis demonstrates the combination meets a pre- defined threshold of clinical activity • Expanded from 20 to 40 patients in 1H 20 • R/M SCCHN is an indication of high unmet need • Enrollment completed o Monalizumab + cetixumab has potential to improve over cetuxiumab alone (SOC) • Data expected in 2021 *Amended from the initially agreed $100M milestone due upon dosing of the first patient, following longer patient follow-up and maturing survival data from Cohort 2 and following discussions with AstraZeneca **< 2 lines of prior therapy must include prior PD-(L)1 inhibitors; ***No prior systemic regimens in the R/M setting or prior PD-(L)1 inhibitors SCCHN” Squamous Cell Carcinoma of the Head and Neck; “SOC” Standard of Care; “ORR” Objective Response Rate 9 Monalizumab Key Results of Cetuximab Combination: Data from Cohort 1, ESMO 2019 Acceptable safety profile, ORR of 27.5% and favorable trends in OS in post IO R/M SCCHN patients Mona + Cetuximab – Best Overall Response & ORR OS in All Patients All Patients IO-naïve IO-pretreated (n=40) (n=22) (n=18) Best overall response: n (%) Complete Response 1 (2.5%) 1 (4.5%) 0 (0.0%) Partial response 10 (25.0%) 7 (31.8%) 3 (16.7%) Stable disease 22 (55.0%) 10 (45.5%) 12 (66.7%) Progressive disease 7 (17.5%) 4 (18.2%) 3 (16.7%) Months Overall Response Rate: % 27.5% 36.4% 16.7% [95%CI] [16-43] [20-57] [6-39] OS According to Prior IO Median overall survival (OS) 8.5 months 7.8 months 14.1 months [95%CI] [7.5-16.4] [6.9-15.8] [8.0-NR] ORR and OS for Currently Approved Treatment Options for R/M SCCHN After Platinum Based Chemotherapy Cetuximab Pembrolizumab Nivolumab (Erbitux) (Keytruda) (Opdivo) ORR 12.6% 16.0% 13.3% Median OS 5.8 months 8.4 months 7.5 months Months Source: Cohen et al., ESMO 2019 10 Monalizumab Cohort 2: Preliminary Efficacy Results, Presented at ASCO20 Expansion cohort 2 confirmed prospectively the ORR reported in Cohort 1 in IO-pretreated patients Expansion Cohort 2 ASCO20 Virtual Scientific Program: Monalizumab + cetuximab • “Combination of Monalizumab and IO Pretreated R/M SCCHN Cetuximab in Patients with Recurrent or Metastatic Head and Neck ORR % [95% CI] 20% [11-35] Squamous Cell Cancer Previously PR n (%) 8 (20%) Treated with Platinum-based Chemotherapy and PD-(L)1 Inhibitors”
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