Mouse Model of Endemic Burkitt Translocations Reveals the Long-Range Boundaries of Ig-Mediated Oncogene Deregulation
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation Alexander L. Kovalchuka,1, Camilo Ansarah-Sobrinhob,1,Ofir Hakimc,1, Wolfgang Reschb, Helena Tolarováb, Wendy Duboisd, Arito Yamaneb, Makiko Takizawab, Isaac Kleinf, Gordon L. Hagerc, Herbert C. Morse IIIa, Michael Potterd,1, Michel C. Nussenzweige,f,2, and Rafael Casellasb,g,2 aLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; bGenomics and Immunity, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; cLaboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; dLaboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; eLaboratory of Molecular Immunology, and fHoward Hughes Medical Institute, The Rockefeller University, New York, NY 10065; and gCenter of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Edited by Klaus Rajewsky, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, and approved May 22, 2012 (received for review January 5, 2012) Human Burkitt lymphomas are divided into two main clinical human Burkitt lymphomas (BLs), mouse plasmacytomas (PCTs), variants: the endemic form, affecting African children infected with and rat immunocytomas (15, 16). malaria and the Epstein-Barr virus, and the sporadic form, distrib- Human BLs are divided into two main clinical variants: the uted across the rest of the world. However, whereas sporadic endemic form, affecting African children infected with malaria translocations decapitate Myc from 5′ proximal regulatory ele- and the Epstein-Barr virus, and the sporadic form, distributed ments, most endemic events occur hundreds of kilobases away across the rest of the world (17).
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