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Possible Interference by Common Odoriferous Foodstuffs in the Determination of Breath-Alcohol Content Using the Intoxilyzer 4011AS
University of the Pacific Scholarly Commons University of the Pacific Theses and Dissertations Graduate School 1988 Possible interference by common odoriferous foodstuffs in the determination of breath-alcohol content using the Intoxilyzer 4011AS Gail Eileen Jones University of the Pacific Follow this and additional works at: https://scholarlycommons.pacific.edu/uop_etds Part of the Medicine and Health Sciences Commons Recommended Citation Jones, Gail Eileen. (1988). Possible interference by common odoriferous foodstuffs in the determination of breath-alcohol content using the Intoxilyzer 4011AS. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/2152 This Thesis is brought to you for free and open access by the Graduate School at Scholarly Commons. It has been accepted for inclusion in University of the Pacific Theses and Dissertations by an authorized administrator of Scholarly Commons. For more information, please contact [email protected]. POSSIBLE INI'ERFERENCE BY CXM-m OOORIFERCUS FOODS'IUFFS IN 'lliE DEI'ERMINATICN OF' BREATH-ALCOHOL CCNl'ENl' USIN:; THE INIDXILyzER 40llAS Gail Eileen Jones, B. s. Cameron University, Lawton, Oklahana, 1982 A 'lhesis sutmi.tted in Partial F\llfillmant of the RequirE!!"!Vants for the Degree of M:tster of Science in Toxicology at the University of the Pacific December 2, 1988 This thesis, written and submitted by Gail Eileen Jones is approved for recommendation to the Committee on Graduate Studies, University of the Pacific Dean of the School or Department Chairman: Co-Chairman Co-Chairman Dated__ ()_~__;~~~-+----'/ 9-=(......:.( __ _ TABLE OF CCNI'ENI'S Page LIST OF TABLES •• ii LIST OF FIGURES. • . i ii INI'RODUcriCN • • • • 1 Historical and Theoretical Backgroun::i • 1 Drinking, Driving and the I.aw • • 1 Ethanol : Chemical and Pharrca.cological Properties 10 Physiological Principles and the Detennination of Bl ood ~1. -
Approach to Acute Ataxia in Childhood: Diagnosis and Evaluation Lalitha Sivaswamy, MD
FEATURE Approach to Acute Ataxia in Childhood: Diagnosis and Evaluation Lalitha Sivaswamy, MD opsoclonus myoclonus ataxia syndrome, must receive special mention because the underlying disease process may be ame- nable to surgical intervention. In the tod- dler- and school-age groups, certain condi- tions (such as stroke and acute cerebellitis) require immediate recognition and imag- ing, whereas others (such as post-infec- tious ataxia and concussion) require close follow-up. Finally, mention must be made of diseases outside of the central nervous system that can present with ataxia, such as Guillain-Barré syndrome. he word ataxia is derived from the Greek word ataktos, which T means “lack of order.” Ataxia is characterized by disturbances in the voluntary coordination of posture and movement. In children, it is most prominent during walking (the sine qua non being a staggering gait with impaired tandem), but it can also be present during sitting or standing, or © Shutterstock when the child is performing move- Abstract Lalitha Sivaswamy, MD, is Associate Profes- ments of the arms, legs, or eyes. sor of Pediatrics and Neurology, Department Ataxia refers to motor incoordination that is This review focuses on the etiol- of Neurology, Wayne State University School of usually most prominent during movement ogy and diagnostic considerations for Medicine; and Medical Director, Headache Clinic, or when a child is attempting to maintain a acute ataxia, which for the purposes of Children’s Hospital of Michigan. sitting posture. The first part of the review this discussion refers to ataxia with a Address correspondence to: Lalitha Sivas- focuses on the anatomic localization of symptom evolution time of less than wamy, MD, Department of Neurology, Wayne ataxia — both within the nervous system 72 hours.1 State University School of Medicine, Children’s and without — using a combination of his- Motor coordination requires sensory Hospital of Michigan, 3901 Beaubien, Detroit, MI torical features and physical findings. -
Scientific Opinion
SCIENTIFIC OPINION ADOPTED: DD Month YEAR doi:10.2903/j.efsa.20YY.NNNN 1 Evaluation of the health risks related to the 2 presence of cyanogenic glycosides in foods other than raw 3 apricot kernels 4 5 EFSA Panel on Contaminants in the Food Chain (CONTAM), 6 Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl- 7 Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean-Charles Leblanc, Carlo 8 Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Dieter 9 Schrenk, Christiane Vleminckx, Heather Wallace, Diane Benford, Leon Brimer, Francesca 10 Romana Mancini, Manfred Metzler, Barbara Viviani, Andrea Altieri, Davide Arcella, Hans 11 Steinkellner and Tanja Schwerdtle 12 Abstract 13 In 2016, the EFSA CONTAM Panel published a scientific opinion on the acute health risks related to 14 the presence of cyanogenic glycosides (CNGs) in raw apricot kernels in which an acute reference dose 15 (ARfD) of 20 µg/kg bw was established for cyanide (CN). In the present opinion, the CONTAM Panel 16 concluded that this ARfD is applicable for acute effects of CN regardless the dietary source. Estimated 17 mean acute dietary exposures to cyanide from foods containing CNGs did not exceed the ARfD in any 18 age group. At the 95th percentile, the ARfD was exceeded up to about 2.5-fold in some surveys for 19 children and adolescent age groups. The main contributors to exposures were biscuits, juice or nectar 20 and pastries and cakes that could potentially contain CNGs. Taking into account the conservatism in 21 the exposure assessment and in derivation of the ARfD, it is unlikely that this estimated exceedance 22 would result in adverse effects. -
Police Powers, Trespass and Expressive Rights Under the Canadian Constitution
The Peter A. Allard School of Law Allard Research Commons Faculty Publications Allard Faculty Publications 2007 Police Powers, Trespass and Expressive Rights Under the Canadian Constitution W. Wesley Pue Allard School of Law at the University of British Columbia, [email protected] Follow this and additional works at: https://commons.allard.ubc.ca/fac_pubs Part of the Constitutional Law Commons, and the Indigenous, Indian, and Aboriginal Law Commons Citation Details W Wesley Pue, "Police Powers, Trespass and Expressive Rights Under the Canadian Constitution" (2007) [unpublished]. This Working Paper is brought to you for free and open access by the Allard Faculty Publications at Allard Research Commons. It has been accepted for inclusion in Faculty Publications by an authorized administrator of Allard Research Commons. Pue, Trespass & Rights, paper prepared for the Ipperwash Inquiry, 2005-02-04 1 of 96 Trespass and Expressive Rights By. W. Wesley Pue … the rights guaranteed in the Charter erect around each individual, metaphorically speaking, an invisible fence over which the state will not be allowed to trespass. The role of the courts is to map out, piece by piece, the parameters of the fence. • R. v. Morgentaler, [1988] 1 S.C.R. 30, at p. 164, per Wilson J. Paper prepared for The Ipperwash Inquiry, The Honourable Sidney B. Linden, Commissioner, established by the Government of Ontario on November 12, 2003, under the Public Inquiries Act to inquire and report on events surrounding the death of Dudley George, shot during a protest by First Nations representatives at Ipperwash Provincial Park in 1995. Pue, Trespass & Rights, paper prepared for the Ipperwash Inquiry, 2005-02-04 2 of 96 Table of Contents Introduction The Summit of the Americas, 2001 Legal Issues “Authorized by Law” R. -
Alcohol Sensitivity As an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility Between Rodents and Humans
brain sciences Review Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans Clarissa C. Parker 1,*, Ryan Lusk 2 and Laura M. Saba 2,* 1 Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, VT 05753, USA 2 Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; [email protected] * Correspondence: [email protected] (C.C.P.); [email protected] (L.M.S.) Received: 3 September 2020; Accepted: 9 October 2020; Published: 13 October 2020 Abstract: Alcohol use disorder (AUD) is a complex, chronic, relapsing disorder with multiple interacting genetic and environmental influences. Numerous studies have verified the influence of genetics on AUD, yet the underlying biological pathways remain unknown. One strategy to interrogate complex diseases is the use of endophenotypes, which deconstruct current diagnostic categories into component traits that may be more amenable to genetic research. In this review, we explore how an endophenotype such as sensitivity to alcohol can be used in conjunction with rodent models to provide mechanistic insights into AUD. We evaluate three alcohol sensitivity endophenotypes (stimulation, intoxication, and aversion) for their translatability across human and rodent research by examining the underlying neurobiology and its relationship to consumption and AUD. We show examples in which results gleaned from rodents are successfully integrated with information from human studies to gain insight in the genetic underpinnings of AUD and AUD-related endophenotypes. Finally, we identify areas for future translational research that could greatly expand our knowledge of the biological and molecular aspects of the transition to AUD with the broad hope of finding better ways to treat this devastating disorder. -
Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum
International Journal of Environmental Research and Public Health Review Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum Hiroshi Mitoma 1,* , Mario Manto 2,3 and Aasef G. Shaikh 4 1 Medical Education Promotion Center, Tokyo Medical University, Tokyo 160-0023, Japan 2 Unité des Ataxies Cérébelleuses, Service de Neurologie, CHU-Charleroi, 6000 Charleroi, Belgium; [email protected] 3 Service des Neurosciences, University of Mons, 7000 Mons, Belgium 4 Louis Stokes Cleveland VA Medical Center, University Hospitals Cleveland Medical Center, Cleveland, OH 44022, USA; [email protected] * Correspondence: [email protected] Abstract: Ethanol consumption remains a major concern at a world scale in terms of transient or irreversible neurological consequences, with motor, cognitive, or social consequences. Cerebellum is particularly vulnerable to ethanol, both during development and at the adult stage. In adults, chronic alcoholism elicits, in particular, cerebellar vermis atrophy, the anterior lobe of the cerebellum being highly vulnerable. Alcohol-dependent patients develop gait ataxia and lower limb postural tremor. Prenatal exposure to ethanol causes fetal alcohol spectrum disorder (FASD), characterized by permanent congenital disabilities in both motor and cognitive domains, including deficits in general intelligence, attention, executive function, language, memory, visual perception, and commu- nication/social skills. Children with FASD show volume deficits in the anterior lobules related to sensorimotor functions (Lobules I, II, IV, V, and VI), and lobules related to cognitive functions (Crus II and Lobule VIIB). Various mechanisms underlie ethanol-induced cell death, with oxidative stress and Citation: Mitoma, H.; Manto, M.; Shaikh, A.G. Mechanisms of endoplasmic reticulum (ER) stress being the main pro-apoptotic mechanisms in alcohol abuse and Ethanol-Induced Cerebellar Ataxia: FASD. -
Successfully Defending an OUI Case
CHAPTER 10 Successfully Defending an OUI Case David P. Sorrenti, Esq. Sorrenti & Delano, Brockton § 10.1 Introduction ............................................................................... 10–1 § 10.2 The Offense ................................................................................ 10–2 § 10.3 Operation ................................................................................... 10–2 § 10.3.1 Definition .................................................................... 10–2 § 10.3.2 Defense ....................................................................... 10–3 § 10.4 Public Way .................................................................................. 10–4 § 10.4.1 Definition .................................................................... 10–4 § 10.4.2 Stipulation of Proof .................................................... 10–5 § 10.4.3 Defense ....................................................................... 10–5 § 10.5 Under the Influence ................................................................... 10–6 § 10.5.1 Diminished Capacity .................................................. 10–6 (a) General Principles ............................................. 10–6 (b) Opinion Evidence .............................................. 10–7 (c) Erratic Operation ............................................... 10–7 (d) Odor of Alcohol ................................................. 10–7 (e) Red or Glassy Eyes ............................................ 10–8 (f) Slurred Speech .................................................. -
The Impact of Systematically Varying the Duration of Breath Samples During Infrared-Based Alcohol Breath Testing
Western Michigan University ScholarWorks at WMU Dissertations Graduate College 6-2002 The Impact of Systematically Varying the Duration of Breath Samples during Infrared-Based Alcohol Breath Testing Chris C. Clatterbuck Western Michigan University Follow this and additional works at: https://scholarworks.wmich.edu/dissertations Part of the Equipment and Supplies Commons, Investigative Techniques Commons, and the Other Psychiatry and Psychology Commons Recommended Citation Clatterbuck, Chris C., "The Impact of Systematically Varying the Duration of Breath Samples during Infrared-Based Alcohol Breath Testing" (2002). Dissertations. 1188. https://scholarworks.wmich.edu/dissertations/1188 This Dissertation-Open Access is brought to you for free and open access by the Graduate College at ScholarWorks at WMU. It has been accepted for inclusion in Dissertations by an authorized administrator of ScholarWorks at WMU. For more information, please contact [email protected]. THE IMPACT OF SYSTEMATICALLY VARYING THE DURATION OF BREATH SAMPLES DURING INFRARED-BASED ALCOHOL BREATH TESTING by Chris C. Clatterbuck A Dissertation Submitted to the Faculty of The Graduate College m partial fulfillment of the requirements for the Degree of Doctor of Philosophy Department of Counselor Education and Counseling Psychology Western Michigan University Kalamazoo. Michigan June 2002 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. THE IMPACT OF SYSTEMATICALLY VARYING THE DURATION OF BREATH SAMPLES DURING -
Management of Alcohol Use Disorders: a Pocket Reference for Primary Care Providers
Management of alcohol use disorders: A pocket reference for primary care providers Meldon Kahan, MD Edited by Kate Hardy, MSW and Sarah Clarke, PhD Acknowledgments Mentoring, Education, and Clinical Tools for Addiction: Primary Care–Hospital Integration (META:PHI) is an ongoing initiative to improve the experience of addiction care for both patients and providers. The purpose of this initiative is to set up and implement care pathways for addiction, foster mentoring relationships between addiction physicians and other health care providers, and create and disseminate educational materials for addiction care. This pocket guide is excerpted from Safe prescribing practices for addictive medications and management of substance use disorders in primary care: A pocket reference for primary care providers, a quick-reference tool for primary care providers to assist them in implementing best practices for prescribing potentially addictive medications and managing substance use disorders in primary care, endorsed by the College of Family Physicians of Canada. This excerpt is a guide to talking to patients about their alcohol use and managing at-risk drinking and alcohol use disorders. We thank those who have given feedback on this document: Dr. Mark Ben-Aron, Dr. Peter Butt, Dr. Delmar Donald, Dr. Mike Franklyn, Dr. Melissa Holowaty, Dr. Anita Srivastava, and three anonymous CFPC reviewers. We gratefully acknowledge funding and support from the following organizations: Adopting Research to Improve Care (Health Quality Ontario & Council of Academic Hospitals of Ontario) The College of Family Physicians of Canada Toronto Central Local Health Integration Network Women’s College Hospital Version date: December 19, 2017 © 2017 Women’s College Hospital All rights reserved. -
Herbert H. Leckie, Jd
HERBERT H. LECKIE, JD 349 Mountain Road, Lebanon, NJ 08833 (908) 534-8300 [email protected] dwi-dreconsulting.com Skills Summary Over 33 years of experience in “Driving While Under the Influence” investigations. Expertise includes evaluation of both alcohol and drug-related DWI matters. Extensive experience in a number of breath test instruments including the Alcotest 7110 MK 111-C instrument. A former instructor in the Standardized Field Sobriety Tests (SFST’s) wherein there is the ability to evaluate the proper administration and scoring of the tests administered in DWI investigations. Evaluation of “Refusal” cases including procedural issues related to the Subjective Refusal charge. As a former Drug Recognition Expert Instructor and Course Manager, ability to evaluate cases in which an individual has been charged with operating a motor vehicle while under the influence of drugs (both illicit and prescription). Accepted as an expert witness in the United States Federal District Court, numerous Superior Courts as well as numerous municipal courts throughout the State of New Jersey. Also accepted as an expert witness in Supreme Court, New York County as well as New York County Criminal Court. Education Juris Doctorate, Seton Hall University School of Law (2000) • Student Bar Association President (1999-2000) Bachelor of Science, Rutgers University (1995) • Administration of Justice – with Honors Associate of Science, Middlesex County College (1982) • Criminal Justice Career Experience/Training DWI-DRE Consulting Services, Inc. (2018-Present) President Providing instruction, expert review, analysis and testimony in the following areas: Breathalyzer 900/900A, Alcotest 7110 MK III-C, Standardized Field Sobriety Test Procedures and Drug Recognition Expert Evaluation Case Review. -
Ataxia Digest
Ataxia Digest 2015 Vol. 2 News from the Johns Hopkins Ataxia Center 2016 What is Ataxia? Ataxia is typically defined as the presence of Regardless of the type of ataxia a person may have, it abnormal, uncoordinated movements. This term is is important for all individuals with ataxia to seek proper most often, but not always, used to describe a medical attention. For the vast majority of ataxias, a neurological symptom caused by dysfunction of the treatment or cure for the disease is not yet available, so cerebellum. The cerebellum is responsible for many the focus is on identifying symptoms related to or motor functions, including the coordination of caused by the ataxia. By identifying the symptoms of voluntary movements and the maintenance of balance ataxia it becomes possible to treat those symptoms and posture. through medication, physical therapy, exercise, other therapies and sometimes medications. Those with cerebellar ataxia often have an “ataxic” gait, which is walking The Johns Hopkins Ataxia Center has a that appears unsteady, uncoordinated multidisciplinary clinical team that is dedicated to and staggered. Other activities that helping those affected by ataxia. The center has trained require fine motor control like writing, specialist ranging from neurologists, nurses, reading, picking up objects, speaking rehabilitation specialists, genetic counselors, and many clearly and swallowing may be others. This edition of the Ataxia Digest will provide abnormal. Symptoms vary depending you with information on living with ataxia and the on the cause of the ataxia and are multidisciplinary center at Johns Hopkins. specific to each person. Letter from the Director Welcome to the second edition of the Ataxia Digest. -
Medication Use and Driving Risks by Tammie Lee Demler, BS Pharm, Pharmd
CONTINUING EDUCATION Medication Use and Driving Risks by Tammie Lee Demler, BS Pharm, PharmD pon successful completion of this ar- the influence of alcohol has Useful Websites ticle, pharmacists should be able to: long been accepted as one 1. Identify the key functional ele- of the most important causes ■ www.dot.gov/ or http://www.dot.gov/ ments that are required to ensure of traffic accidents and driv- odapc/ competent, safe driving. ing fatalities. Driving under Website of the U.S. Department of 2. Identify the side effects associated with pre- the influence of alcohol has Transportation, which contains trends Uscription, over-the-counter and herbal medi- been studied not only in ex- and law updates. It also contains an cations that can pose risks to drivers. perimental research, but also excellent search engine. 3. Describe the potential impact of certain medi- in epidemiological road side ■ www.mayoclinic.com/health/herbal- cation classes on driving competence. studies. The effort that society supplements/SA00044 4. Describe the pharmacist’s duty to warn re- has made to take serious le- Website for the Mayo Clinic, with garding medications that have the potential to gal action against those who information about herbal supplements. impair a patient’s driving competence. choose to drink and drive It offers an expert blog for further exploration about specific therapies and 5. Provide counseling points to support safe driv- has resulted in the significant to receive/share insight about personal ing in all patients who are receiving medication. deterrents of negative social driving impairment with herbal drugs. stigma and incarceration.