Profiles

September 3, 2015

BIBLIOGRAPHY

Irwin J. Kopin, M.D. Scientist Emeritus, Clinical Neuroscience Section National Institute of Neurological Disorders and Stroke Bethesda, Maryland 20892

1959

1. Kopin, I.J.: loading and excretion of 5-hydroxy-indole-acetic acid in normal and schizophrenic subjects. Science 129: 835-836, 1959.

2. Axelrod, J., Kopin, I.J. and Mann, J.D.: 3-Methoxy-4-hydroxy-phenylglycol sulfate, a new metabolite of epinephrine and . Biochim Biophys Acta 36: 576-577, 1959.

3. Kopin, I.J.: Discussant of "Tryptophan metabolism in schizophrenics and in controls," by E. A. Zeller. In Gibbs, F.A. (Ed.): Molecules and Mental Health. Philadelphia, J.B. Lippincot Company, 1959 (pp. 65-67).

1960

4. Kopin, I.J. and Axelrod, J.: Presence of 3-methoxy-4-hydroxy-phenylglycol and in phaeochromocytoma tissue. Nature 185: 788, 1960.

5. Kopin, I.J.: Technique for the study of alternate metabolic pathways: Epinephrine metabolism in man. Science 131: 1372-1374, 1960.

6. Kopin, I.J., Pare, C.M.B., Axelrod, J. and Weissbach, H.: 6-Hydroxylation, the major metabolic pathway for . Biochim Biophys Acta 40: 377-378, 1960.

7. Kopin, I.J. and Axelrod, J.: 3,4-dihydroxyphenylglycol, a metabolite of epinephrine. Arch Biochem Biophys 89: 148, 1960.

8. Kopin, I.J. and Rosenberg, I.N.: Idiopathic hypoparathyroidism: Report of a case with autopsy findings. Ann Intern Med 53: 1238- 1249, 1960.

1961

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9. LaBrosse, E.H., Axelrod, J., Kopin, I.J. and Kety, S.S.: Metabolism of 7-H3-epinephrine- D-bitartrate in normal young men. J Clin Invest 40: 253-260, 1961.

10. Hertting, G., Axelrod, J., Kopin, I.J. and Whitby, L.G.: Lack of uptake of after chronic denervation of sympathetic nerves. Nature 189: 66, 1961.

11. Kopin, I.J., Axelrod, J. and Gordon, E.: The metabolic fate of H3-epinephrine and C14- metanephrine in the rat. J Biol Chem 236: 2109-2113, 1961.

12. Axelrod, J., Whitby, L.G., Hertting, G. and Kopin, I.J.: Studies on the metabolism of catecholamines. Circ Res 9: 715-720, 1961.

13. Axelrod, J. and Kopin, I.J.: Estimation of 0-methylated metabolites of catecholamines. In Quastel, J.H. (Ed.): Methods in Medical Research, Volume IX. Chicago: Year Book Publishers, 1961 (pp. 153-158).

14. Kopin, I.J., Pare, C.M.B., Axelrod, J. and Weissbach, H.: The fate of melatonin in animals. J Biol Chem 236: 3072-3075, 1961.

1962

15. Potter, L.T., Axelrod, J. and Kopin, I.J.: Differential binding and release of norepinephrine and tachyphylaxis. Biochem Pharmacol 11: 254-256, 1962.

16. LaBrosse, E.H., Axelrod, J., Kopin, I.J. and Kety, S.S.: The metabolism of tritium- labeled epinephrine in men. In: Tritium in the Physical and Biological Sciences, Volume II. Vienna: International Atomic Energy Agency 1962 (pp.407-412).

17. Axelrod, J., Gordon, E., Hertting, G., Kopin, I.J. and Potter, L.T.: On the mechanism of tachyphylaxis to tyramine in the isolated rat heart. Br J Pharmacol 19: 56-63, 1962.

18. Kopin, I.J., Hertting, G. and Gordon, E.K.: Fate of norepinephrine-H3 in the isolated perfused rat heart. J Pharmacol Exp Ther 138: 34-40, 1962.

19. Kopin, I.J. and Gordon, E.K.: Metabolism of norepinephrine-H3 released by tyramine and reserpine. J Pharmacol Exp Ther 138: 351-359, 1962.

1963

20. Kopin, I.J.: Estimation of relative magnitudes of alternative metabolic pathways. In Glick, D. (Ed): Methods of Biochemical Analysis, Volume XI. New York: John Wiley and Sons, Inc., 1963 (pp. 247-278).

21. Kopin, I.J. and Bridgers, W.: Differences in D- and L-norepinephrine-H3. Life Sci 5: 356-362, 1963.

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22. Kopin, I.J. and Gordon, E.: Metabolism of administered and drug-released norepinephrine-7-H3 in the rat. J Pharmacol Exp Ther 140: 207-216, 1963.

23. Wurtman, R.J., Kopin, I.J. and Axelrod, J.: Thyroid function and the cardiac disposition of catecholamines. Endocrinology 73: 63- 74, 1963.

24. Kopin, I.J. and Axelrod, J.: The role of monoamine oxidase in the release and metabolism of norepinephrine. Ann N.Y. Acad Sci 107: 848-853, 1963.

25. Rosell, S., Kopin, I.J. and Axelrod, J.: Fate of H3-noradrenaline in skeletal muscle before and following sympathetic stimulation. Am J Physiol 205: 317-321, 1963.

26. Kopin, I.J. and Wurtman, R.J.: Flow of uterine blood and the aestrous cycle. Nature 199: 386-387, 1963.

27. Baldessarini, R.J. and Kopin, I.J.: Assay of tissue levels of S-adenosyl-methionine. Anal Biochem 6: 289-292, 1963.

28. Kopin, I.J. and Gordon, E.K.: Origin of norepinephrine in the heart. Nature 199: 1289, 1963.

29. Wurtman, R.J., Axelrod, J. and Kopin, I.J.: Uterine epinephrine and blood flow in pregnant and postparturient rats. Endocrinology 73: 501-503, 1963.

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1964

30. Rosell, S., Axelrod, J. and Kopin, I.J.: Release of tritiated epinephrine following sympathetic nerve stimulation. Nature 201: 301, 1964.

31. Kopin, I.J.: Storage and metabolism of catecholamines: The role of monoamine oxidase. Pharmacol Rev 16: 179-191, 1964.

32. Fischer, J.E., Musacchio, J.M., Kopin, I.J. and Axelrod, J.: Effects of denervation on the uptake and ß-hydroxylation of tyramine in the rat salivary gland. Life Sci 3: 413-419, 1964.

33. Musacchio, J.M., Kopin, I.J. and Snyder, S.: Effects of disulfiram on tissue norepinephrine content and subcellular distribution of , tyramine and their ß- hydroxylated metabolites. Life Sci 3: 769-775, 1964.

34. Kopin, I.J.: Metabolism of the catecholamines. Z Klin Chem 2: 115-123, 1964.

35. Fischer, J.E., Kopin, I.J. and Wurtman, R.J.: Effects of lumbar sympathectomy on the uterine uptake of catecholamines. Nature 203: 938-939, 1964.

36. Kopin, I.J., Fischer, J.E., Musacchio, J. and Horst, W.D.: Evidence for a false neurochemical transmitter as a mechanism for the hypotensive effect of monoamine oxidase inhibitors. Proc Nat Acad Sci USA 52: 716-721, 1964.

37. Glowinski, J., Axelrod, J., Kopin, I.J. and Wurtman, R.J.: Physiological disposition of H3-norepinephrine in the developing rat. J Pharmacol Exp Ther 146: 48-53, 1964.

38. Kopin, I.J.: Disposition and fate of hormones. In Litwack, G. and Kritchevsky, D. (Eds): Actions of Hormones on Molecular Processes. New York: John Wiley and Sons, Inc., 1964 (pp. 257-267).

39. LaBrosse, E.H., Kopin, I.J., Felix, W.R., Jr. and Westlake, R.J.: Urinary tryptamine and indole-3-acetic acid excretion by schizophrenic patients: Use of the tryptamine/indole acetic acid ratio as an index of monoamine oxidase inhibition. J Psychiatr Res 2: 185-197, 1964.

40. Henkin, R.I. and Kopin, I.J.: Abnormalities of taste and smell thresholds in familial dysautonomia: Improvement with methacholine. Life Sci 3: 1319-1325, 1964.

41. Wurtman, R.J., Kopin, I.J., Horst, W.D. and Fischer, J.E.: Epinephrine and organ blood flow: Effect of hyperthyroidism, cocaine and denervation. Am J Physiol 207: 1247-1250, 1964.

1965

42. Fischer, J.E., Kopin, I.J. and Axelrod, J.: Evidence for extraneuronal binding of norepinephrine. J Pharmacol Exp Ther 147: 181-185, 1965.

43. Kopin, I.J., Fischer, J.E., Musacchio, J.M., Horst, W.D. and Weise, V.K.: False neurochemical transmitters and the mechanism of sympathetic blockade by monoamine oxidase inhibitors. J Pharmacol Exp Ther 147: 186-193, 1965. 4

44. Musacchio, J.M., Weise, V.K. and Kopin, I.J.: Mechanism of norepinephrine binding. Nature 205: 606-607, 1965.

45. Bhagat, B., Gordon, E.K. and Kopin, I.J.: Norepinephrine synthesis and the pressor responses to tyramine in the spinal cat. J Pharmacol Exp Ther 147: 319-323, 1965.

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46. Glowinski, J., Kopin, I.J. and Axelrod, J.: Metabolism of 7-3H-norepinephrine in the rat brain. J Neurochem 12: 25-30, 1965.

47. Musacchio, J.M., Kopin, I.J. and Weise, V.K.: Subcellular distribution of some sympathomimetic and their ß-hydroxylated derivatives in the rat heart. J Pharmacol Exp Ther 148: 22-28, 1965.

48. Fischer, J.E., Horst, W.D. and Kopin, I.J.: ß-hydroxylated sympathomimetic amines as false . Br J Pharmacol 24: 477-484, 1965.

49. Kopin, I.J., Godon, E.K. and Horst, W.D.: Studies of uptake of 1-norepinephrine-14C. Biochem Pharmacol 14: 753-759, 1965.

50. Musacchio, J.M., Fischer, J.E. and Kopin, I.J.: Effect of chronic sympathetic denervation on subcellular distribution of some sympathomimetic amines. Biochem Pharmacol 14: 898-900, 1965.

51. Kopin, I.J.: Origin disposition and metabolic fate of catecholamines. In Roth, I.J. (Ed): Isotopes in Experimental Pharmacology. Chicago: University of Chicago Press, 1965 (pp. 307- 313).

52. Fischer, J.E., Horst, W.D. and Kopin, I.J.: Norepinephrine metabolism in hypertrophied rat hearts. Nature 207: 951-953, 1965.

53. Kopin, I.J.: Estimation of alternative metabolic pathways of catecholamines in man. In Rothchild, S. (Ed): Advances in Tracer Methodology, Volume II. New York: Plenum Press, 1965 (pp. 237- 242).

1966

54. Poch, G.R. and Kopin, I.J.: The role of octopamine in tachyphylaxis to tyramine. Biochem Pharmacol 15: 210-212, 1966.

55. Fischer, J.E., Weise, V.K. and Kopin, I.J.: Release of tritiated bretylium by sympathetic nerve stimulation. Nature 209: 778-779, 1966.

56. Kopin, I.J.: Biochemical aspects of release of norepinephrine and other amines from sympathetic nerve endings. Pharmacol Rev 18: 513-523, 1966.

57. Musacchio, J.M., Fischer, J.E. and Kopin, I.J.: Subcellular distribution and release by sympathetic nerve stimulation of dopamine and a-methyl dopamine. J Pharmacol Exp Ther 152: 56-61, 1966.

58. Musacchio, J.M., Goldstein, M., Anagnoste, B., Poch, G. and Kopin, I.J.: Inhibition of dopamine-ß-hydroxylase by disulfiram in vivo. J Pharmacol Exp Ther 152: 51-55, 1966.

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59. Musacchio, J.M., Bhagat, B., Jackson, C.J. and Kopin, I.J.: The effect of disulfiram on the -methyl-dopa in the reserpine- treated cat. J Pharmacol Exp Ther 152: 293-297, 1966.

60. Baldessarini, R.J. and Kopin, I.J.: Tritiated norepinephrine: Release from brain slices by electrical stimulation. Science 152: 1630-1631, 1966.

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61. Kopin, I.J.: Biochemical aspects of storage and release of biogenic amines from sympathetic nerves. In Euler, U.S. von, Rosell, S. and Uvnas, B. (Ed): Mechanism of Release of Biogenic Amines. Oxford: Pergamon Press, 1966 (pp. 229-246).

62. Kopin, I.J.: Metabolism and disposition of catecholamines in the central and peripheral nervous systems. In Levine, R. (Ed): Endocrines and the Central Nervous System, Res. Ner. Men. Dis. Volume XLIII. Baltimore: The Williams and Wilkins Company 1966 (pp. 343-353).

63. Cohen, R.A., Kopin, I.J., Creveling, C.R., Musacchio, J.M., Fischer, J.E., Crout, J.R. and Gill, J.R., Jr.: False neurochemical transmitters. Combined Clinical Staff Conference at the National Institutes of Health. Ann Intern Med 65: 347-362, 1966.

64. Schildkraut, J.J., Scanberg, S.M. and Kopin, I.J.: The effects of lithium ion on H3- norepinephrine metabolism in brain. Life Sci 5: 1479-1483, 1966.

65. Baldessarini, R.J. and Kopin, I.J.: S-adenosylmethionine in brain and other tissues. J Neurochem 13: 769-777, 1966.

66. Fischer, J.E., Weise, V.K. and Kopin, I.J.: Interactions of bretylium and acetylcholine at sympathetic nerve endings. J Pharmacol Exp Ther 153: 523-529, 1966.

67. Westlake, R.J. and Kopin, I.J.: Assessment of dopamine-ß-oxidase activity in the skin of guinea pig in vivo. J Invest Dermatol 47: 169-179, 1966.

68. Masson, D.T., Kopin, I.J. and Braunwald, E.: Abnormalities in reflex control of the circulation in familial dysautonomia. Effects of changes in posture on venous and arterial constriction in normal subjects and patients with dysautonomia. Am J Med 41: 898-909, 1966.

1967

69. Sedvall, G.C. and Kopin, I.J.: Acceleration of norepinephrine synthesis in the rat submaxillary gland in vivo during sympathetic nerve stimulation. Life Sci 6: 45-51, 1967.

70. Sedvall, G.C. and Kopin, I.J.: Influence of sympathetic denervation and nerve impulse activity of hydroxylase in the rat submaxillary gland. Biochem Pharmacol 16: 39-46, 1967.

71. Schanberg, S.M., Schildkraut, J.J. and Kopin, I.J.: The effects of psychoactive drugs on norepinephrine-3H metabolism in brain. Biochem Pharmacol 16: 393-399, 1967.

72. Baldessarini, R.J. and Kopin, I.J.: The effects of drugs on the release of norepinephrine- H3 from central nervous system tissues by electrical stimulation in vitro. J Pharmacol Exp Ther 156: 31-38, 1967.

73. Chase, T.N., Breese, G.R. and Kopin, I.J.: release from brain slices by electrical stimulation: Regional differences and effect of LSD. Science 157: 1461-1463, 1967.

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74. Schildkraut, J.J., Schanberg, S.M., Breese, G.R. and Kopin, I.J.: Norepinephrine metabolism and drugs used in the affective disorders: A possible mechanism of action. Am J Psychiatry 124: 600-608, 1967.

75. Schanberg, S.M., Schildkraut, J.J. and Kopin, I.J.: The effects of pentobarbital on the fate of intracisternally administered norepinephrine-H3. J Pharmacol Exp Ther 157: 311-318, 1967.

76. Nyback, H., Sedvall, G. and Kopin, I.J.: Accelerated synthesis of dopamine-C14 from tyrosine-C14 in rat brain after chlorpromazine. Life Sci 6: 2307-2312, 1967.

77. Kopin, I.J.: Acetylcholine, bretylium and release of norepinephrine from sympathetic nerve endings. Ann NY Acad Sci 144: 588-592, 1967.

78. Kopin, I.J.: Relationship of psychotropic drug action to the metabolism and transport of catecholamines. In Brill, H., Cole, J.O., Deniker, P., Hippius, H. and Bradley, P.B. (Eds.): Neuropsychopharmacology. Amsterdam: Excerpta Medica Foundation, 1967 (pp. 330-334).

79. Kopin, I.J.: The adrenergic synapse. In Quarton, G.C., Melnechuk, T. and Schmitt, F.O., (Eds): The Neurosciences. New York: The Rockefeller University Press, 1967 (pp. 427-432).

1968

80. Sedvall, G.C., Weise, V.K. and Kopin, I.J.: The rate of norepinephrine synthesis measured in vivo during short intervals; influence of adrenergic nerve impulse activity. J Pharmacol Exp Ther 159: 274-282, 1968.

81. Chase, T.N. and Kopin, I.J.: Stimulus-induced release of substances from olfactory bulb using the push-pull cannula. Nature 127: 466-467, 1968.

82. Schanberg, S.M., Schildkraut, J.J., Breese, G.R. and Kopin, I.J.: Metabolism of -H3 in rat brain: Identification of conjugated 3-methoxy-4-hydroxyphenylglycol as the major metabolite. Biochem Pharmacol 17: 247-254, 1968.

83. Fischer, J.E., Weise, V.K. and Kopin, I.J.: False adrenergic transmitter release from the isolated cat heart. Am J Med Sci 255: 158-162, 1968.

84. Kopin, I.J.: False adrenergic transmitters. Annu Rev Pharmacol 8: 377-394, 1968.

85. Kopin, I.J., Breese, G.R., Krauss, K.R. and Weise, V.K.: Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation. J Pharmacol Exp Ther 161: 271-278, 1968.

86. Schildkraut, J.J., Kopin, I.J., Schanberg, S.M. and Durell, J.: Norepinephrine metabolism and psychoactive drugs in the endogenous depressions. Pharmakopsychiatr Neuropsychopharmakol 1: 69-92, 1968.

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87. Chase, T.N., Breese, G.R., Carpenter, D.O., Schanberg, S.M. and Kopin, I.J.: Stimulation-induced release of serotonin. Adv Pharmacol 6: 351-364, 1968.

88. Kopin, I.J.: Monoamine oxidase inhibitors and false neurochemical transmitters. In Cheymol, J. and Boissier, J.R. (Eds.): Monoamine Oxidase Inhibitors: Relationship between Pharmacological and Clinical Effects. Oxford: Pergamon Press, 1968 (pp. 83-89).

89. Kopin, I.J.: Biosynthesis and metabolism of catecholamines. Anesthesiology 29: 654- 660, 1968.

90. Kopin, I.J. and Weise, V.K.: Effect of reserpine and metaraminol on excretion of and 3-methoxy-4-hydroxyphenolglycol in the rat. Biochem Pharmacol 17: 1461-1464, 1968.

91. Schanberg, S.M., Breese, G.R., Schildkraut, J.J., Gordon, E.K. and Kopin, I.J.: 3- methoxy-4-hydroxyphenylglycol sulfate in brain and cerebrospinal fluid. Biochem Pharmacol 17: 2006-2008, 1968.

92. Schanberg, S.M., Schildkraut, J.J., Krivanek, J. and Kopin, I.J.: Effect of cortical spreading depression on norepinephrine-H3 metabolism in brain stem. Experientia 24: 909, 1968.

93. Horst, W.K., Kopin, I.J. and Ramey, E.R.: Influence of sodium and calcium on norepinephrine uptake by isolated perfused rat hearts. Am J Physiol 215: 817-822, 1968.

94. Katz, R.I., Chase, T.N. and Kopin, I.J.: Evoked release of norepinephrine and serotonin from brain slices: Inhibition by lithium. Science 162: 466-467, 1968.

95. Kopin, I.J.: Identification of "True" and "False" transmitters. In Efron, D.H. (Ed): Psychopharmacology, A Review of Progress 1957-1967. U.S. Department of Health, Education and Welfare, Public Health Service Publication No. 1836. Washington: U.S. Government Printing Office, 1968 (pp. 57-60).

96. Kopin, I.J.: The influence of false adrenergic transmitters on adrenergic neurotransmission. In Wolstenholme, G.E.W. and O’Connor, M. (Ed) Adrenergic Neurotransmission. Boston: Little, Brown and Company, 1968 (pp. 95-104).

1969

97. Kopin, I.J.: How does lithium work: (Editorial). New Engl J Med 280: 560-561, 1969.

98. Goodwin, J.S., Katz, R.I. and Kopin I.J.: Effect of bromide on evoked release of monoamines from brain slices and intact atria. Nature 221: 556-557, 1969.

99. Breese, G.R., Chase, T.N. and Kopin, I.J.: Metabolism of some phenylethylamines and their ß-hydroxylated analogs in brain. J Pharmacol Exp Ther 165: 9-13, 1969.

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100. Chase, T.N., Katz, R.I. and Kopin, I.J.: Release of 3H serotonin from brain slices. J Neurochem 16: 607-615, 1969.

101. Kopin, I.J.: Biogenic amines and drugs action. In Black, P. (Ed): Drugs and the Brain. Baltimore: The Johns Hopkins Press, 1969 (pp. 3-15).

102. Axelrod, J. and Kopin, I.J.: The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves. In Akert, K. and Waser, P.G. (Ed): Progress in Brain Research, Volume XXXI. Amsterdam: Elsevier Publishing Company, 1969 (pp. 21-32).

103. Breese, G.R., Chase, T.N. and Kopin, I.J.: Metabolism of tyramine-3H and octopamine- 3H by rat brain. Biochem Pharmacol 18: 863-869, 1969.

104. Katz, R.I., Goodwin, J.S. and Kopin, I.J.: Disposition of neurotransmitters in experimental mouse glioma. Life Sci 8: 561-569, 1969.

105. Katz, R.I. and Kopin, I.J.: Release of norepinephrine-3H and serotonin-3H evoked from brain slices by electrical-field stimulation - calcium dependency and the effects of lithium, ouabain and tetrodotoxin. Biochem Pharmacol 18: 1935-1939, 1969.

106. Katz, R.I. and Kopin, I.J.: Electrical field-stimulated release of norepinephrine-H3 from rat atrium: Effects of ions and drugs. J Pharmacol Exp Ther 169: 229-236, 1969.

107. Katz, R.I., Chase, T.N. and Kopin, I.J.: Effect of ions on stimulus-induced release of amino acids from mammalian brain slices. J Neurochem 16: 961-967, 1969.

108. Katz, R.I. and Kopin, I.J.: Effect of D-LDS and related compounds on release of norepinephrine-H3 and serotonin-H3 evoked from brain slices by electrical stimulation. Pharmacol Res Commun 1: 54-62, 1969.

109. Schildkraut, J.J., Schanberg, S.M., Kopin, I.J. and Durell, J.: Affective disorders and norepinephrine pharmacology. Int Psychiatr Clin 6: 83-141, 1969.

110. Schildkraut, J.J., Schanberg, S.M., Breese, G.R. and Kopin, I.J.: Effects of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain. Biochem Pharmacol 18: 1971- 1978, 1969.

111. Kopin, I.J., Weise, V. and Sedvall, G.C. Effect of false transmitters on norepinephrine synthesis. J Pharmacol Exp Ther 170: 246-252, 1969.

112. Chase, T.N., Katz, R.I. and Kopin, I.J.: Effect of anticonvulsants on brain serotonin. Trans Am Neurol Assoc 94: 236-238, 1969.

1970

113. Chase, T.N., Katz, R.I. and Kopin, I.J.: Effect of diazepam on fate of intracisternally injected serotonin-C14. Neuropharmacology 9: 103-108, 1970.

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114. Krauss, K.R., Kopin, I.J. and Weise, V.K.: The effect of bretylium on retention in rat heart. J Pharmacol Exp Ther 172: 282- 288, 1970.

115. Krauss, K.R., Carpenter, D.O. and Kopin, I.J.: Acetylcholine-induced release of norepinephrine in the presence of tetrodotoxin. J Pharmacol Exp Ther 173: 416-421, 1970.

116. Breese, G.R., Chase, T.N. and Kopin, I.J.: Effect of monoamine oxidase inhibitors on the disposition of intracisternally administered metaraminol-3H. Biochem Pharmacol 19: 525-532, 1970.

117. Breese, G.R., Kopin, I.J. and Weise, V.K.: Effects of amphetamine derivatives on brain dopamine and noradrenaline. Br J Pharmacol 38: 537-545, 1970.

118. Gewirtz, G.P. and Kopin, I.J.: Release of dopamine-ß-hydroxylase with norepinephrine during cat splenic nerve stimulation. Nature 227: 406-407, 1970.

119. Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Elevation of adrenal tyrosine hydroxylase and phenylethanolamine-N-methyl transferase by repeated immobilization of rats. Endocrinology 87: 744-749, 1970.

120. Lemberger, L., Witt, E.D., Davis, J.M. and Kopin, I.J.: The effects of haloperidol and chlorpromazine on amphetamine metabolism and amphetamine stereotype behavior in the rat. J Pharmacol Exp Ther 174: 428-433, 1970.

121. Louis, W.J., Krauss, K.R., Kopin, I.J. and Sjoerdsma, A.: Catecholamine metabolism in hypertensive rats. Circ Res 27: 589- 594, 1970.

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122. Ng, K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: L-dopa-induced release of cerebral monoamines. Science 170: 76-77, 1970.

123. Ng, K.Y., Chase, T.N. and Kopin, I.J.: Drug-induced release of 3H- norepinephrine and 3H-serotonin from brain slices. Nature 228: 468-469, 1970.

124. Parks, L.C., Watanabe, A.M. and Kopin, I.J.: Prevention or reversal of levodopa-induced cardiac arrhythmias by decarboxylase inhibitors. Lancet II: 1014-1015, 1970.

125. Gewirtz, G.P. and Kopin, I.J.: Effect of intermittent nerve stimulation on norepinephrine synthesis and mobilization in the perfused cat spleen. J Pharmacol Exp Ther 175: 514-520, 1970.

126. Lemberger, L., Silberstein, S.D., Axelrod, J. and Kopin, I.J.: Marihuana: Studies on the disposition and metabolism of delta-9-tetra-hydrocannabinol in man. Science 170: 1320-1322, 1970.

127. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Effect of hypo-physectomy on immobilization-induced elevation of tyrosine hydroxylase and phenylethanolamine-N-methyl transferase in the rat adrenal. Endocrinology 87: 1323-1329, 1970.

128. Kopin, I.J. and Baldessarini, R.J.: Assay of tissue levels of S- adrenosylmethionine. In Tabor, C.W. and Tabor, H. (Ed): Amino Acids and Amines. New York: Academic Press, Inc., 1970 (pp. 397- 400).

129. Kopin, I.J.: Catecholamines in blood pressure regulation. In Barbeau, A. and McDowell, F.H. (Ed): L-Dopa and Parkinsonism. Philadelphia: F.A. Davis Company, 1970 (pp. 277-280).

1971

130. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Enhanced synthesis of adrenal dopamine-ß-hydroxylase induced by repeated immobilization in rats. Mol Pharmacol 7: 81-86, 1971.131. Paul, M.I., Kvetnansky, R., Cramer, H., Silbergeld, S. and Kopin, I.J.: Immobilization stress-induced changes in adrenocortical and medullary cyclic-AMP content in the rat. Endocrinology 88: 338- 344, 1971.

132. Wender, P.H., Epstein, R.S., Kopin, I.J. and Gordon, E.K.: Urinary monoamine metabolites in children with minimal brain dysfunction. Am J Psychiatry 127: 1411-1415, 1971.

133. Chase, T.N., Breese, G.R., Gordon, E.K. and Kopin, I.J.: Catecholamine metabolism in the dog: Comparison of intravenously and intraventricularly administered 14C-dopamine and 3H-norepinephrine. J Neurochem 18: 135-140, 1971.

134. Silbergeld, S., Kvetnansky, R., Sigalso, G.L., Weise, V.K. and Kopin, I.J.: Levels of adrenal catecholamine-synthesizing enzymes after postmortem treatment in rats and after necropsy in human beings. J Lab Clin Med 77: 290-297, 1971.

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135. Gewirtz, G.P., Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Effect of hypophysectomy on adrenal dopamine-ß-hydroxylase activity in the rat. Mol Pharmacol 7: 163-168, 1971.

136. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Catechol-amine-synthesizing enzymes in the rat adrenal gland during exposure to cold. Am J Phychiatry 220: 928-931, 1971.

137. Kopin, I.J.: Unnatural amino acids as precursors of false transmitters. Fed Proc 30: 904- 907, 1971.

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138. Johnson, D.G., Thoa, N.B. and Kopin, I.J.: Inhibition of norepinephrine biosynthesis by chlorpromazine in the guinea pig vas deferens. J Pharmacol Exp Ther 177: 146-154, 1971.

139. Lemberger, L., Axelrod, J. and Kopin, I.J.: The disposition and metabolism of tryptamine and the in vivo formation of 6-hydroxy-tryptamine in the rabbit. J Pharmacol Exp Ther 177: 169-176, 1971.

140. Silberstein, S.D., Johnson, D.G., Jacobowitz, D.M. and Kopin, I.J.: Sympathetic reinnervation of the rat iris in organ culture. Proc Natl Acad Sci USA 68: 1121-1124, 1971.

141. Kvetnansky, R., Silbergeld, S., Weise, V.K. and Kopin, I.J.: Effects of restraint on rat adrenomedullary response to 2-deoxyglucose. Psycho-pharmacologia 20: 22-31, 1971.

142. Ng, K.Y., Colburn, R.W. and Kopin, I.J.: Effects of L-dopa on efflux of cerebral monoamines from synaptosomes. Nature 230: 331- 332, 1971.

143. Thoa, N.B., Johnson, D.G., Kopin, I.J. and Weiner, N.: Acceleration of catecholamine formation in the guinea pig vas deferens after hypogastric nerve stimulation: Roles of tyrosine hydroxylase and new protein synthesis. J Pharmacol Exp Ther 178: 442-449, 1971.

144. Silbergeld, S., Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Effect of repeated administration of 2-deoxy-D-glucose or insulin on catecholamine-synthesizing enzymes in rat adrenals. Biochem Pharmacol 20: 1763-1769, 1971.

145. Weinshilboum, R.M., Kvetnansky, R., Axelrod, J. and Kopin, I.J.: Elevation of serum dopamine-ß-hydroxylase activity with forced immobilization. Nat New Biol 230: 287-288, 1971.

146. Carpenter, D., Breese, G., Schanberg, S., and Kopin, I.J.: Serotonin and dopamine: Distribution and accumulation in aplysia nervous and non-nervous tissue. Int J Neurosci 2: 49- 56, 1971.

147. Kopin, I.J.: Discussion of panel on amine metabolism. In Williams, T.A., Katz, M.M. and Shield, J.A., Jr. (Ed): Recent Advances in the Psychobiology of the Depressive Illnesses. Washington: U.S. Government Printing Office, 1971 (pp. 43-47).

148. Thoa, N.B., Johnson, D.G. and Kopin, I.J.: Selective release of newly synthesized norepinephrine in the guinea pig vas deferens during hypogastric nerve stimulation. Eur J Pharmacol 15: 29-35, 1971.

149. Gewirtz, G.P., Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Effect of ACTH and dibutyryl cyclic AMP on catecholamine synthesizing enzymes in the adrenals of hypophysectomized rats. Nature 230: 462-463, 1971.

150. Ng, K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: Dopamine: Stimulation-induced release from central neurons. Science 172: 487-489, 1971.

151. Watanabe, A.M., Parks, L.C. and Kopin, I.J.: Modification of the cardiovascular effects of L-dopa by decarboxylase inhibitors. J Clin Invest 50: 1322-1328, 1971.

15

152. Lemberger, L., Tamarkin, N.R., Axelrod, J. and Kopin, I.J.: Delta-9- tetrahydrocannabinol: Metabolism and disposition in long-term mari-huana smokers. Science 173: 72-74, 1971.

153. Kvetnansky, R., Weise, V.K., Gewirtz, G.P. and Kopin, I.J.: Synthesis of adrenal catecholamines in rats during and after immobilization stress. Endocrinology 89: 46-49, 1971.

154. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Effect of dibutyryl cyclic- AMP on adrenal catecholamine-synthesizing enzymes in repeatedly immobilized hypophysectomized rats. Endo-crinology 89: 50-55, 1971.

155. Dubois, A., Watanabe, A. and Kopin, I.J.: Postoperative gastric ileus. Experimental study and treatment. Rendic R. Gastroenterology 3: 116-117, 1971.

156. Kopin, I.J.: Accumulation of drugs at sympathetic nerve endings. In Brodie, B.B. and Gillette, R.J. (Ed): Handbook of Experimental Pharmacology, Volume XXVIII/I (Concepts in Biochemical Pharmacology). New York: Springer/Verlag, 1971 (pp. 317-327).

157. Johnson, D.G., Thoa, N.B., Weinshilboum, R., Axelrod, J. and Kopin, I.J.: Enhanced release of dopamine-ß-hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins. Proc Natl Acad Sci USA 68: 2227-2230, 1971.

158. Davis, J.M., Kopin, I.J., Lemberger, L. and Axelrod, J.: Effects of urinary pH on amphetamine metabolism. Ann N.Y. Acad Sci 179: 493-501, 1971. 159. Johnson, D.G., Gorden, P. and Kopin, I.J.: A sensitive radioimmuno-assay for 7S nerve growth factor antigens in serum and tissues. J Neurochem 18: 2355-2362, 1971.

160. Kopin, I.J.: The chemical nature, biosynthesis and metabolism of the catecholamines. In Sunderman, F.W. and Sunderman, F.W., Jr. (Ed): Laboratory Diagnosis of Endocrine Disease. St. Louis: Warren H. Green, Inc. 1971 (pp. 423-427).

161. Lemberger, L., Axelrod, J. and Kopin, I.J.: Metabolism and disposi-tion of D-9- tetrahydrocannabinol in man. Pharmacol Rev 23: 371-380, 1971.

162. Kopin, I.J.: Effects of drugs on catecholamine synthesis. In Ho, B.T. and McIsaac, W.M. (Ed): Advances in Behavioral Biology, Volume I (Brain Chemistry and Mental Disease). New York: Plenum Press, 1971 (pp. 73-82).

163. Kopin, I.J.: False neurotransmitters in the mechanism of action of central nervous system and cardiovascular drugs. In Biel, J.H. and Abood, L.G. (Ed): Medicinal Research Series, Volume 5/B (Biogenic Amines and Physiological Membranes in Drug Therapy). New York: Marcel Dekker, Inc., 1971 (pp. 329-353).

164. Weinshilboum, R.M., Thoa, N.B., Johnson, D.G., Kopin, I.J. and Axelrod, J.: Proportional release of norepinephrine and dopamine-ß-hydroxylase from sympathetic nerves. Science 174: 1349-1351, 1971.

16

165. Lemberger, L., Axelrod, J. and Kopin, I.J.: Metabolism and dispo-sition of tetrahydrocannabinols in naive subjects and chronic marihuana users. Ann N.Y. Acad Sci 191: 142-154, 1971.

1972

166. Thoa, N.B., Johnson, D.G. and Kopin, I.J.: Inhibition of norepinephrine bio-synthesis by a-methyl amino acids in the guinea pig vas diferens. J Pharmacol Exp Ther 180: 71-77, 1972.

167. Kopin, I.J.: Introduction. In Rall, J.E. and Kopin, I.J. (Ed): Methods in Investigative and Diagnostic Endocrinology, Volume II (Thyroid and Biogenic Amines). Amsterdam: North- Holland Publishing Company, 1972 (pp. 309-317).

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168. Kopin, I.J.: Separation and estimation of radioactively labelled catecholamines and their metabolites. In Rall, J.E. and Kopin, I.J. (Ed): Methods in Investigative and Diagnostic Endo- crinology, Volume II (Thyroid and Biogenic Amines). Amsterdam: North-Holland Publishing Company 1972 (pp. 489-496).

169. Thoa, N.B., Wooten, G.F., Axelrod, J. and Kopin, I.J.: Inhibition of release of dopamine- ß-hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B. Proc Natl Acad Sci USA 69: 520-522, 1972.

170. Kopin, I.J. and Silberstein, S.D.: Axons of sympathetic neurons: Transport of enzymes in vivo and properties of axonal sprouts in vitro. Pharmacol Rev 24: 245-254, 1972.

171. Colburn, R.W. and Kopin, I.J.: Effects of reserpine and tyramine on release of norepinephrine from synaptosomes. Biochem Pharmacol 21: 733-736, 1972.

172. Kopin, I.J.: False transmitters. In Snyder, S.H. (Ed): Perspectives in Neuropharmacology. Cambridge: Oxford University Press, Inc., 1972 (pp. 339-348).

173. Kopin, I.J.: Metabolic degradation of catecholamines. The relative importance of different pathways under physiological conditions and after administration of drugs. In Blaschko, H. and Muscholl, E. (Eds): Handbook of Experimental Pharmacology, Volume XXXIII (Catecholamines). New York: Springer/Verlag, 1972 (pp. 270-282).

174. Silberstein, S.D., Johnson, D.G., Hanbauer, I., Bloom, F.E. and Kopin, I.J.: Axonal sprouts and 3H norepinephrine uptake by superior cervical ganglia in organ culture. Proc Natl Acad Sci USA 69: 1450-1454, 1972.

175. Ng, L.K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: L-dopa in parkinsonism. Neurology 22: 688-696, 1972.

176. Johnson, D.G., Silberstein, S.D., Hanbauer, I. and Kopin, I.J.: The role of nerve growth factor in the ramification of sympathetic nerve fibres into the rat iris in organ culture. J Neurochem 19: 2025-2029, 1972.

177. Lamprecht, F., Eichelman, B., Thoa, N.B., Williams, R.B. and Kopin, I.J.: Rat fighting behavior: Serum dopamine-ß-hydroxylase and hypothalamic tyrosine hydroxylase. Science 177: 1214-1215, 1972.

178. Thoa, N.B., Weise, V.K. and Kopin, I.J.: Effect of L-dihydroxy- phenylalamine on methylation of 3H-norepinephrine and 3H-histamine. Biochem Pharmacol 21: 2345-2350, 1972.

179. Ng, L.K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: Release of [3H]-dopamine by L- 5-hydroxytryptophan. Brain Res 45: 499-505, 1972.

180. Kopin, I.J.: Aminergic neurons and substitute transmitters in brain. In Kopin, I.J. (Ed): Research Publications: Association for Research in Nervous and Mental Disease, Volume 50 (Neurotransmitters). Baltimore: Williams and Wilkins Company, 1972 (pp. 207-215).

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181. Kopin, I.J., Silberstein, S.D., Johnson, D.G., Hanbauer, I. and Jacobowitz, D.M.: Sympathetic reinnervation of the rat iris in vitro. In Costa, E., Iversen, L.L. and Paoletti, R. (Eds): Advances in Biochemical Psychopharmacology, Volume 6 (Studies of Neurotransmitters at the Synaptic Level). New York: Raven Press, 1972 (pp. 89-92).

182. Silberstein, S.D., Lemberger, L., Klein, D.C., Axelrod, J. and Kopin, I.J.: Induction of adrenal tyrosine hydroxylase in organ culture. Neuro-pharmacology 11: 721-726, 1972.

19

183. Ng, L.K.Y., Colburn, R.W. and Kopin, I.J.: Effects of L-dopa on accumulation and efflux of monoamines in particles of rat brain homogenates. J Pharmacol Exp Ther 168: 316- 325, 1972.

184. Hanbauer, I., Johnson, D.G., Silberstein, S.D. and Kopin, I.J.: Pharmacological and kinetic properties of uptake of [3H]-norepine-phrine by superior cervical ganglia of rats in organ culture. Neuropharmacology 11: 857-862, 1972.

185. Murphy, D.L. and Kopin, I.J.: The transport of biogenic amines. In Hokin, L.E. (Ed): Metabolic Pathways, Volume VI (Metabolic Transport). New York: Academic Press, Inc., 1972 (pp 503-542).

186. Vogel, S.A., Silberstein, S.D., Berv, K.R. and Kopin, I.J.: Stimu-lation-induced release of norepinephrine from rat superior cervical ganglia in vitro. Eur J Pharmacol 20: 308-311, 1972.

1973

187. Dubois, A., Watanabe, A.M. and Kopin, I.J.: Postoperative gastric ileus. Am J Dig Dis 18: 39-42, 1973.

188. Lamprecht, F., Kvetnansky, R., Ng, L.K.Y., Williams, R.B. and Kopin, I.J.: Effect of -9- tetrahydrocannabinol on immobilization-induced changes in rat adrenal medullary enzymes. Eur J Pharmacol 21: 249-251, 1973.

189. Williams, R. B., Ng, L.K.Y., Lamprecht, F., Roth, K. and Kopin, I.J.: -9- tetrahydrocannabinol: A hypotensive effect in rats. Psychopharmacologia 28: 269-274, 1973.

190. Kvetnansky, R. and Kopin, I.J.: Activity of adrenal catecholamine- producing enzymes and their regulation after stress. In Kovach, A.G.B. (Ed): Advances in Experimental Medicine and Biology Volume 33 (Neurohumoral and Metabolic Aspects of Injury). New York: Plenum Publishing Corporation, 1973 (pp. 517-533).

191. Lamprecht, F., Williams, R.B. and Kopin, I.J.: Serum dopamine-beta-hydroxylase during development of immobilization-induced hypertension. Endocrinology 92: 953-956, 1973.

192. Maengwyn-Davies, G.D., Johnson, D.G., Thoa, N.B., Weise, V.K. and Kopin, I.J.: Influence of isolation and fighting on adrenal tyrosine hydroxylase and phenylethanolamine-N- methyltransferase activities in three strains of mice. Psychopharmacologia 28: 339- 350, 1973.

193. Kopin, I.J.: Modification by inhibition of decarboxylase of the cardio-vascular effects of L-dopa in animals. In Yahr, M.P. (Ed): Advances in Neurology, Volume 2 (Treatment of Parkinsonism the Role of Dopa Decarboxylase Inhibitors). New York: Raven Press, 1973 (pp. 137-148).

194. Weir, R.L., Chase, T.N., Ng, L.K.Y. and Kopin, I.J.: 5-hydroxy-indoleacetic acid in spinal fluid: Relative contribution from brain and spinal cord. Brain Res 52: 409-412, 1973.

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195. Moss, J., Kazic, T., Henry, D.P. and Kopin, I.J.: Scorpion venom-induced discharge of catecholamines accompanied by hypertension. Brain Res 54: 381-385, 1973.

196. Johnson, D.G., Weise, V.K., Hanbauer, I., Silberstein, S.D. and Kopin, I.J.: Dopamine-ß- hydroxylase activity during sympathetic reinnervation of rat iris in organ culture. Neurobiology 3: 88- 90, 1973.

197. Wooten, G.F., Thoa, N.B., Kopin, I.J. and Axelrod, J.: Enhanced release of dopamine-ß- hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3’,5’- monophosphate and theophylline. Mol Pharmacol 9: 178-183, 1973.

198. Cramer, H., Johnson, D.G., Hanbauer, I., Silberstein, S.D. and Kopin, I.J.: Accumulation of adenosine 3’,5’-monophosphate induced by catechol-amines in the rat superior cervical ganglion in vitro. Brain Res 53: 97-104, 1973.

199. Kopin, I.J.: Control of synthesis, transport and release of dopamine-beta-hydroxylase and tyrosine hydroxylase. In Mandell, A.J. (Ed): New Concepts on Regulation. New York: Plenum Publishing Cor-poration, 1973 (pp. 21-31).

200. Hanbauer, I., Kopin, I.J., Maengwyn-Davies, G.D., Thoa, N.B. and Weise, V.K.: Effects of vinblastine on catecholamine-biosynthetic enzymes in heart, sympathetic ganglion and adrenal glands of rats. Br. J Pharmacol 48: 106-112, 1973.

201. Ng, L.K.Y., Lamprecht, F., Williams, R.B. and Kopin, I.J: D9-tetrahydro-cannabinol and ethanol: Differential effects on sympathetic activity in differing environmental setting. Science 180: 1368-1369, 1973.

202. Hanbauer, I. and Kopin, I.J.: Mechanism involved in the trans-synaptic increase of tyrosine hydroxylase and dopamine-ß-hydroxy-lase activity in sympathetic ganglia. Naunyn- Schmiedeberg’s Arch Pharmacol 280: 39-48, 1973.

203. Dubois, A., Weise, V.K. and Kopin, I.J.: Postoperative ileus in the rat: Physiopathology, etiology and treatment. Ann Surg 178: No. 6, 1973.

204. Thomas, J.A., Van Orden, L.S., III, Redick, J.A. and Kopin, I.J.: Immunological localization of dopaminie-ß-hydroxylase on the chromaffin granule membrane. Frontiers in Catecholamines Research. New York and Oxford: Pergamon Press, 1973 (pp. 79-81), also in J. Psychiatr Res 11: 317-319, 1974.

205. Kopin, I.J., Berv, K.R. and Webb, J.G.: Sympathetic ganglia in culture. Frontiers in Catecholamine Research. New York and Oxford: Pergamon Press, 1973 (pp. 239-244).

1974

206. Dubois, A., Kopin, I.J., Pettigrew, K.D. and Jacobowitz, D.M.: Chemical and histochemical studies of postoperative sympathetic activity in the digestive tract in rats. Gastroenterology 66: 403-407, 1974.

21

207. Moss, J., Colburn, R.W. and Kopin, I.J.: Scorpion toxin-induced catechol-amine release from synaptosomes. J Neurochem 22: 217-221, 1974.

208. Hanbauer, I., Jacobowitz, D.M. and Kopin, I.J.: Effects of vinblastine on noradrenergic axons. Br J Pharmacol 50: 219-225, 1974.

209. Thoa, N.B., Costa, J.L., Moss, J. and Kopin, I.J.: Mechanism of release of norepinephrine from peripheral adrenergic neurones by the calcium ionophores X 537A and A 23187. Life Sci 14: 1705- 1719, 1974.

210. Colburn, R.W., Ng, L.K.Y., Lemberger, L. and Kopin, I.J.: Subcellular distribution of D9-tetrahydrocannabinol in rat brain. Biochem Pharmacol 23: 873-877, 1974.

211. Kobayashi, R.M. and Kopin, I.J.: The effects of stress and environ-mental lighting on histamine in the rat brain. Brain Res 74: 356-359, 1974.

212. Hanbauer, I., Kopin, I.J. and Jacobowitz, D.M.: Effects of vinblastine on peripheral autonomic nerves: Degeneration and formation of new nerve fibers. In Fuxe, K., Olson, L. and Zotterman, Y. (Eds): Dynamics of Degeneration and Growth in Neurons. Oxford and New York: Pergamon Press, 1974 (pp. 485-497).

213. Moss, J., Thoa, N.B. and Kopin, I.J.: On the mechanism of scorpion toxin-induced release of norepinephrine from peripheral adrenergic neurons. J Pharmacol Exp Ther 190: 39- 48, 1974.

214. Kobayashi, R.M., Palkovits, M., Kopin, I.J. and Jacobowitz, D.M.: Bio-chemical mapping of noradrenergic nerves arising from the rat locus coeruleus. Brain Res 77: 269-279, 1974.

215. Kizer, J.S., Palkovits, M., Zivin, J., Brownstein, M., Saavedra, J.M. and Kopin, I.J.: The effect of endocrinological manipulations on tyrosine hydroxylase and dopamine-ß-hydroxylase activities in individual hypothalmic nuclei of the adult male rat. Endocrinology 95: 799-812, 1974.

216. Gordon, E.K., Oliver, J., Black, K. and Kopin, I.J.: Simultaneous assay by mass fragmentography of vanillyl mandelic acid homovanillic acid and 3-methoxy-4-hydroxy- phenethylene glycol in cerebrospinal fluid and urine. Biochem Med 11: 32-40, 1974.

217. Kopin, I.J., Palkovits, M., Kobayashi, R.M. and Jacobowitz,D.M.: Quantitative relationship of catecholamine content and histofluorescence in brain of rats. Brain Res 80: 229- 235, 1974.

218. Redick, J.A., Thomas, J.A., Van Orden, L.S., III, Van Orden, D.E. and Kopin, I.J.: Immunocytochemical localization of dopamine-ß-hydroxylase in adrenal chromaffin granules. Neuropharmacology 13: 1005-1014, 1974.

219. Roizen, M.F., Moss, J., Henry, D.P. and Kopin, I.J.: Effects of halothane on plasma catecholamines. Anesthesiology 41: 432-439, 1974.

22

220. Reid, J.L. and Kopin, I.J.: Significance of plasma dopamine-ß-hydroxylase activity as an index of sympathetic neuronal function. Proc Natl Acad Sci USA 71: 4392-4394, 1974.

221. Hawks, R.L., Kopin, I.J., Colburn, R.W. and Thoa, N.B.: Norcocaine: A pharmacologically active metabolite of cocaine found in brain. Life Sci 15: 2189-2195, 1974.

222. Kopin, I.J.: Regulation of catecholamine-synthesizing enzymes. J Psychiatr Res 11: 335-338, 1974.

223. Lamprecht, F., Ebert, M.H., Turek, I. and Kopin, I.J.: Serum dopamine-beta-hydroxylase in depressed patients and the effect of electroconvulsive shock treatment. Psychopharmacologia 40: 241- 248, 1974.

224. Lamprecht, F., Eichelman, B.S., Williams, R.B., Wooten, G.F. and Kopin, I.J.: Serum dopamine-beta-hydroxylase (DBH) activity and blood pressure response of rat strains to shock- induced fighting. Psychosom Med 36: 298-303, 1974.

225. Kopin, I.J.: Drugs that act at sympathetic nerve endings. Intra-Science Chem Rept 8: 13- 22, 1974.

226. Kopin, I.J.: Neurotransmitters: Basic concepts, development and role in neurological disorders. In: Biologic and Clinical Aspects of Brain Devel-opment, Volume 6. Mead Johnson Symposium on Perinatal Developmental Medicine, 1974.

226a. Thomas, J.A., Van Orden, L.S., III, Redick, J.A. and Kopin, I.J.: Immunological localisation of dopamine---hydroxylase on the--chromaffin granule membrane. J Psychiatr Res 11: 317-319, 1974.

1975

227. Reid, J.L., Zivin, J.A., Foppen, F.H. and Kopin, I.J.: Catecholamine neuro-transmitters and synthetic enzymes in the spinal cord of the rat. Life Sci 16: 975-984, 1975.

228. Thoa, N.B., Wooten, G.F., Axelrod, J. and Kopin, I.J.: On the mechanism of release of norepinephrine from sympathetic nerves induced by depolarizing agents and sympathomimetic drugs. Mol Pharmacol 11: 10-18, 1975.

229. Kobayashi, R.M., Palkovits, M., Jacobowitz, D.M. and Kopin, I.J.: Biochemical mapping of the noradrenergic projection from the locus coeruleus. Neurology 25: 223-233, 1975.

230. Roizen, M.F., Weise, V., Moss, J. and Kopin, I.J.: Plasma catechol-amines: Arterial venous differences and the influence of body temperature. Life Sci 16: 1133-1144, 1975.

231. Dubois, A., Henry, D.P. and Kopin, I.J.: Plasma catecholamines and postoperative gastric emptying and small intestinal propulsion in the rat. Gastroenterology 68: 466-469, 1975.

232. Kizer, J.S., Zivin, J.A., Jacobowitz, D.M. and Kopin, I.J.: The nyctohemeral rhythm of plasma prolactin: Effects of ganglionectomy, pinealectomy, constant light, constant darkness or 6-OH-dopamine administration. Endocrinology 96: 1230-1240, 1975.

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233. Roizen, M.F., Thoa, N.B., Moss, J. and Kopin, I.J.: Inhibition by halothane of release of norepinephrine, but not of dopamine---hydroxylase from guinea-pig vas deferens. Eur J Pharmacol 31: 313-318, 1975.

234. Hanbauer, I., Kopin, I.J., Guidotti, A. and Costa, E.: Induction of tyrosine hydroxylase elicited by beta adrenergic receptor agonists in normal and decentralized sympathetic ganglia: Role of cyclic 3’5-adenosine monophosphate. J Pharmacol Exp Ther 193: 95-104, 1975.

235. Gordon, E.K., Oliver, J. and Kopin, I.J.: The effect of probenecid on catecholamine metabolites in human cerebrospinal fluid analyzed by mass fragmentography. Life Sci 16: 1527-1532, 1975.

236. Webb, J.G., Moss, J., Kopin, I.J. and Jacobowitz, D.M.: Biochemical and histofluorescence studies of catecholamines in superior cervical ganglia in organ culture. J Pharmacol Exp Ther 193, 489-505, 1975.

237. Reid, J.L. and Kopin, I.J.: The effects of ganglionic blockade, reserpine and vinblastine on plasma catecholamines and dopamine---hydroxylase in the rat. J Pharmacol Exp Ther 193: 748-756, 1975.

238. Roizen, M.F., Weise, V., Grobecker, H. and Kopin, I.J.: Plasma catecholamines and dopamine-ß-hydroxylase activity in spontaneously hypertensive rats. Life Sci 17: 283-288, 1975.

239. Gordon, E., Perlow, M., Oliver, J., Ebert M. and Kopin, I.J.: Origins of catecholamine metabolites in monkey cerebrospinal fluid. J Neurochem 25: 347-349, 1975.

240. Wooten, G.F., Kopin, I.J. and Axelrod, J.: Effects of colchicine and vinblastine on axonal transport and transmitter release in sympathetic nerves. Ann N.Y. Acad Sci 253: 528- 534, 1975.

241. Kizer, J.S., Kopin, I.J. and Zivin, J.A.: Estimates of catecholamine turnover rates in individual hypothalamic nuclei of the rat by use of alpha-methyl-para-tyrosine. Br J Pharmacol 54: 243, 1975.

242. Palkovits, M., Kobayashi, R.M., Kizer, J.S., Jacobowitz, D.M. and Kopin, I.J.: Effects of stress on catecholamines and tyrosine hydroxylase activity of individual hypothalamic nuclei. Neuroendo-crinology 18: 144-153, 1975.

243. Webb, J.G., Berv, K.R. and Kopin, I.J.: Induction of dopamine-ß-hydroxylase in superior cervical ganglia in organ culture. Neuro-pharmacology 14: 643-648, 1975.

244. Lamprecht, F., Andres, R. and Kopin, I.J.: Plasma dopamine-ß-hydroxylase: Constance of levels in normotensive adults and decreases with development of blood pressure elevation. Life Sci 17: 749-754, 1975.

24

245. Grobecker, H., Roizen, M.F., Weise, V., Saavedra, J.M. and Kopin, I.J.: Sympathoadrenal medullary activity in young, spontaneously hypertensive rats. Nature 258: 267, 1975.

246. Reid, J.L., Zivin, J.A. and Kopin, I.J.: Central and peripheral adrenergic mechanisms in the development of deoxycorticosterone saline hypertension in rats. Circ Res 37: 569-579, 1975.

247. Zivin, J.A., Reid, J.L., Saavedra, J.M. and Kopin, I.J.: Quanti-tative localization of biogenic amines in the spinal cord. Brain Res 99: 293-301, 1975.

248. Lamprecht, F., Jacobowitz, D.M., Richardson, J.S. and Kopin, I.J.: Central adrenergic neurons in DOCA-salt hypertension. J Neurosci Res 1: 227-234, 1975.

249. Colburn, R.W., Thoa, N.B. and Kopin, I.J.: Influence of ionophores which bind calcium on the release of norepinephrine from synaptosomes. Life Sci 17: 1395-1400, 1975.

250. Roizen, M.F., Kopin, I.J., Palkovits, M., Brownstein, M., Kizer, J.S. and Jacobowitz, D.M.: The effect of two diverse inhalation anesthetic agents on serotonin in discrete regions of the rat brain. Exp Brain Res 24: 203-207, 1975.

251. Ng, L.K.Y. and Kopin, I.J.: Striatal monoamines and false trans-mitters. In Hornykiewicz, O. (Ed.): International Encyclopedia of Pharmacology and Therapeutics. Oxford, England, Pergamon Press Ltd., 1975 (pp. 685-694).

252. Ebert, M.H. and Kopin, I.J.: Differential labelling of origins of urinary catecholamine metabolites by dopamine-C14. Trans Assoc of Am Physicians 1: (xxxviii) 1975 (pp. 256-264).

1976

253. Roizen, M.F., Thoa, N.B., Moss, J. and Kopin, I.J.: Inhibition by cyclopropane of release of norepinephrine, but not dopamine-ß-hydroxylase, from the guinea-pig vas deferens. Anesthesiology 44: 54-56, 1976.

254. Zivin, J.A., Doppman, J.L., Reid, J.L., Tappaz, M.L., Saavedra, J.M., Kopin, I.J. and Jacobowitz, D.M.: Biochemical and histo-chemical studies of biogenic amines in spinal cord trauma. Neurology 26: 99-107, 1976.

255. Ziegler, M., Lake, C.R. and Kopin, I.J.: Deficient sympathetic nervous responses in familial dysautonomia. N Engl J Med 294: 630-633, 1976.

256. Kopin, I.J.: Catecholamines, adrenal hormones and stress. Hosp Pract 11: 49-55, 1976.

25

257. Reid, J.L., Zivin, J.A. and Kopin, I.J.: The effects of spinal cord transection and intracisternal 6-hydroxydopamine on phenyle-thanolamine-N-methyl transferase (PNMT) activity in rat brain cord. J Neurochem 26: 629-631, 1976.

258. Kizer, J.S., Palkovits, M., Kopin, I.J., Saavedra, J.M. and Brownstein, M.J.: Lack of effect of various endocrine manipulations on trytophan hydroxylase activity of individual nuclei of the hypothalamus, limbic system and midbrain of the rat. Endocrinology 98: 743-747, 1976.

259. Zivin, J.A., Reid, J.L., Tappaz, M.L. and Kopin, I.J.: Quantitative localization of tyrosine hydroxylase, dopamine-ß-hydroxylase, phenolethanolamine-N-methyl transferase, and glutamic acid decarboxylase in spinal cord. Brain Res 105: 151-156, 1976.

260. Ziegler, M.G., Lake, C.R. and Kopin, I.J.: Plasma noradrenaline increases with age. Nature 261: 333-334, 1976.

261. Kessler, J.A., Gordon, E.K., Reid, J.L. and Kopin, I.J.: Homovanillic acid and 3- methoxy-4-hydroxyphenylethyleneglycol production by the monkey spinal cord. J Neurochem 26: 1057-1061, 1976.

262. Ziegler, M.G., Lake, C.R. Fappen, F.H., Shoulson, I. and Kopin, I.J.: Norepinephrine in cerebrospinal fluid. Brain Res 108: 436-440, 1976.

263. Lake, C.R., Ziegler, M.G. and Kopin, I.J.: Use of plasma norepine-phrine for evaluation of sympathetic neuronal function in man. Life Sci 18: 1315-1326, 1976.

264. Gordon, E.K., Markey, S.P., Sherman, R.L. and Kopin, I.J.: Con-jugated 3,4- dihydroxyphenylacetic acid (DOPAC) in human and monkey cerebrospinal fluid and rat brain and the effects of pro-benecid treatment. Life Sci 18: 1285-1292, 1976.

265. Roizen, M.F., Kopin, I.J., Thoa, N.B., Zivin, J., Muth, E.A. and Jacobowitz, D.M.: The effect of two anesthetic agents on norepine-phrine and dop-amine in discrete brain nuclei, fiber tracts, and terminal regions of the rat. Brain Res 110: 515-522, 1976.

266. Ziegler, M.G., Lake, C.R., Eldridge, R. and Kopin, I.J.: Plasma norepinephrine and dopamine-ß-hydroxylase in dystonia. In Eldridge, R. and Fahn, S. (Eds.): Advances in Neurology, Vol. 14. New York, Raven Press, 1976 (pp. 307-318).

267. Tappaz, M.L., Zivin, J.A. and Kopin, I.J.: Intraspinal glutamic decarboxylase distribution after transection of the cord at the thoracic level. Brain Res 111: 220-223, 1976.

268. Kopin, I.J., Kaufman, S., Viveros, H., Jacobowitz, D.M., Lake, C.R., Ziegler, M., Lovenberg, W.M. and Goodwin, F.K.: Dopamine-ß-hydroxylase: Basic and Clinical Studies. Ann Intern Med 85: 211- 223, 1976.

269. Weise, V.K. and Kopin, I.J.: Assay of catecholamines in human plasma: Studies of a single isotope radioenzymatic procedure. Life Sci 19: 1673-1686, 1976.

26

270. Thoa, N.B., Tizabi, Y., Kopin, I.J. and Maengwyn-Davies, G.D.: Alterations of mouse adrenal medullary catecholamines and enzymes in response to attack: Effect of pre- and post- treatment with phenobarbital. Psycho-pharmacology 51: 53-57, 1976.

271. Tizabi, Y., Kopin, I.J., Maengwyn-Davies, G.D. and Thoa, N.B.: Attack-induced changes in response to decapitation of plasma catecholamines of victim mice. Psychopharmacol Commun 2: 391-402, 1976.

272. Kopin, I.J.: Catecholamines and stress. In Usdin, E., Kvetnansky, R. and Kopin, I.J. (Eds): Catecholamines and Stress. Pergamon Press, Ltd., Oxford, England 1976 (pp. 1-5).

27

273. Kobayashi, R.M., Palkovits, M., Kizer, J.S., Jacobowitz, D.M. and Kopin, I.J.: Selective alterations of catecholamines and tyrosine hydroxylase activity in the hypothalamus following acute and chronic stress. In Usdin, E., Kvetnansky, R. and Kopin, I.J. (Eds.): Catecholamines and Stress. Pergamon Press Ltd., Oxford, England, 1976 (pp. 29-38).

274. Palkovits, M., Brownstein, M.J., Kizer, J.S., Saavedra, J.M. and Kopin, I.J.: Effect of stress on serotonin and tryptophan hydroxy-lase activity of brain nuclei. In Usdin, E., Kvetnansky, R. and Kopin, I.J. (Eds.): Catecholamines and Stress. Pergamon Press Ltd., Oxford, England 1976 (pp. 51-59).

275. Palkovits, M., Brownstein, M.J., Kizer, J.S., Saavedra, J.M. and Kopin, I.J.: Effect of stress on serotonin concentration and tryptophan hydroxylase activity of brain nuclei. Neuroendro-crinology 22: 298-304, 1976.

276. Markey, S.P., Colburn, R.W. and Kopin, I.J.: Synthesis and puri-fication of 2-Bromo-a- ergocryptine-Br82 Br J Labelled Compd Radiopharm 12: 627-630, 1976.

277. Grobecker, H., Saavedra, J.M., Roizen, M.F., Weise, V., Kopin, I.J. and Axelrod, J.: Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Clin Sci Mol Med 51: 377s-380s, 1976.

1977

278. Lake, C.R., Ziegler, M.G., Coleman, M.D. and Kopin, I.J.: Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects. N Engl J Med 296: 208-209, 1977.

279. Ziegler, M.G., Lake, C.R. and Kopin, I.J.: The sympathetic nervous system defect in primary orthostatic hypotension. N Engl J Med 296: 293-297, 1977.

280. Grobecker, H., Roizen, M.F. and Kopin, I.J.: Effect of tyramine and guan-ethidine on dopamine-ß-hydroxylase activity and norepine-phrine concen-trations in vesicular fraction of the heart and plasma of rats. Life Sci 20: 1009-1016, 1977.

281. Tappaz, M.L., Brownstein, M.J. and Kopin, I.J.: Glutamate decar-boxylase (GAD) and Y-aminobutyric acid (GABA) in discrete nuclei of gypothalamus and substantia nigra. Brain Res 125: 108-121, 1977.

282. Ziegler, M.G., Wood, J.H., Lake, C.R. and Kopin, I.J.: Norepine-phrine and 3-methoxy- 4-hydroxyphenylglycol gradients in human cerebrospinal fluid. Am J Psychiatry 134: 565-568, 1977.

283 Liuzzi, A., Foppen, F.H., Saavedra, J.M., Jacobowitz, D. and Kopin, I.J.: Effect of NGF and dexamethasone on phenylethanolamine-N-methyl transferase (PNMT) activity in neonatal rat superior cervical ganglia. J Neurochem 28: 1215-1220, 1977.

284. Foppen, F.H., Liuzzi, A. and Kopin, I.J.: Gas chromatographic-mass spectrometric identification of epinephrine in rat superior cervical ganglia and formation in vivo. Experientia 33: 596-598, l977. 28

285. Lamprecht, F., Richardson, J.S., Williams, R.B. and Kopin, I.J.: 6-Hydroxy-dopamine destruction of central adrenergic neurones prevents or reverses developing DOCA-salt hypertension in rats. J Neural Transm 40: 149-158, 1977.

29

286. Popper, C.W., Chiueh, C.C. and Kopin, I.J.: Plasma catecholamine concen-trations in unanesthetized rats during sleep, wakefulness, immobilization and after decapitation. J Pharmacol Exp Ther 202: 144-148, 1977.

287. Liuzzi, A., Foppen F.H., Saavedra, J.M., Levi-Montalcini, R. and Kopin, I.J.: Gas Chromatographic-mass spectrometric assay of serotonin in rat superior cervical ganglia. Effects of nerve growth factor and 6-hydroxydopamine. Brain Res 133: 354-357, 1977.

288. Wooten, G.F., Weise, V.K. and Kopin, I.J.: Norepinephrine synthesis con-tributes to the accumulation of catecholamines after ligation of rat sciatic nerves. Brain Res 136: 174-177, 1977.

289. Kopin, I.J.: Catecholamine metabolism (and the biochemical assessment of sympathetic activity). Clin Endocrinol Metab 6: 525-549, 1977.

290. Kopin, I.J.: Methods for measuring brain amine metabolism from blood and urinary amine metabolites. In Usdin, E., Weiner, N. and Youdim, M. (Eds): Structure and Function of monoamine Enzymes. Marcel Dekker, Inc., New York 1977 (pp. 467-476).

291. Grobecker, H., McCarty, R., Saavedra, J.M., Chuieh, C.C. and Kopin,-I.J.: Dopamine--- hydroxylase activity and catecholamine-concentrations in plasma: experimental and essential hypertension. -Postgraduate Med J 53(3): 43-48, 1977.

292. Grobecker, H., Roizen, M.F., Jacobowitz, D.M. and Kopin, I.J.: Effect of prolonged treatment with adrenergic neuron blocking drugs on sympatho-adrenal reactivity in rats. Eur J Pharmacol 46: 125- 133, 1977.

293. Lake, C.R., Major, L.F., Ziegler, M.G. and Kopin, I.J.: Increased sympathetic nervous system activity in alcoholic patients treated with disulfiram. Am J Psychiatry 134: 1411-1414, 1977.

294. Chase, T.N. and Kopin, I.J.: Drug-induced disorders of movement. In Goldensohn, S. and Apel, S.H. (Eds.): Scientific Approaches to Clinical Neurology. Lea and Febiger, Philadelphia, Pa., Chapter 72, 1977 (pp. 1190-1211).

295. Liuzzi, A., Foppen, F.H. and Kopin, I.J.: Stimulation and maintenance by nerve growth factor of phenylethanolamine-N-methyl-transferase in superior cervical ganglia of adult rats. Brain Res 138: 309-315, 1977.

296. Lake, C.R., Ziegler, M.G., Coleman, M. and Kopin, I.J.: Lack of correlation of plasma norepinephrine and dopamine-ß-hydroxylase in hypertensive and normotensive subjects. Cir Res 41: 865-869, 1977.

1978

297. Kopin, I.J.: Noradrenergic neurotransmission. In Lipton, M.A., DiMascio, A. and Killam, K.F. (Eds.): Psychopharmacology: A Generation of Progress. Raven Press, New York, 1978 (pp. 217-219).

30

298. Kopin, I.J.: Measuring turnover of neurotransmitter in human brain. In: Lipton, M.A., DiMascio, A. and Killam, K.F. (Eds.): Psychopharmacology: A generation of Progress. Raven Press, New York, 1978 (pp. 933-942).

299. Roizen, M.F., Moss, J., Henry, D.P., Weise, V. and Kopin, I.J.: Effect of general anesthetics on handling- and decapitation-induced increases in sympathoadrenal discharge. J Pharmacol Exp Ther 204: 11-18, 1978.

31

300. Lake, C.R., Wood, J.H., Ziegler, M.G., Ebert, M.H. and Kopin, I.J.: Probenecid-induced norepinephrine elevations in plasma and cerebrospinal fluid. Arc Gen Psychiatry 35: 237-240, 1978.

301. Weinstock, M., Thoa, N.B. and Kopin, I.J.: a-Adrenoceptors modulate noradrenaline release from axonal sprouts in cultured rat superior cervical ganglia. Eur J Pharmacol 47: 297- 302, 1978.

302. McCarty, R., Chiueh, C.C. and Kopin, I.J.: Behavioral and cardio-vascular responses of spontaneously hypertensive and normotensive rats to inescapable footshock. Behav Biol 22: 405-410, 1978.

303. McCarty, R. and Kopin, I.J.: Alterations in plasma catecholamines and behavior during acute stress in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Life Sci 22: 997-1006, 1978.

304. Chiueh, C.C. and Kopin, I.J.: Centrally mediated release by cocaine of endogenous epinephrine and norepinephrine from the sympathoadrenal medullary system of unanesthetized rats. J Pharmacol Exp Ther 205: 148-154, 1978.

305. Chiueh, C.C., Sun, C.L., Kopin, I.J., Fredericks, W.R. and Rapoport, S.I.: Entry of [3H] norepinephrine, [125] albumin and Evans blue from blood into brain following unilateral osmotic opening of the blood-brain-barrier. Brain Res 145: 291-301, 1978.

306. Blitzer, B.L., Waggoner, J.G., Jones, E.A., Gralnick, H.R., Towne, D., Butler, J., Weise, V., Kopin, I.J., Walters, I., Teychenne, P.F., Goodman, D.G. and Berk, P.D.: A model of fulminant hepatic failure in the rabbit. Gastro-enterology 74: 664-671, 1978.

307. Kopin, I.J., Lake, C.R. and Ziegler, M.G.: Plasma levels of norepinephrine. Ann Intern Med 88: 671-680, 1978.

308. McCarty, R., Chiueh, C.C. and Kopin, I.J.: Spontaneously hyper-tensive rats: Adrenergic hyperresponsivity to anticipation of electric shock. Behav Biol 23: 180-188, 1978.

309. Chiueh, C.C. and Kopin, I.J.: Hyper-responsivity of spontaneously hyper-tensive rat to indirect measurement of blood pressure. Am J Physiol 234: H690-H695, 1978.

310. McCarty, R. and Kopin, I.J.: Pregnancy: Its effects on blood pressure, heart rate and sympatho-adrenal activity in spontaneously hypertensive rats. Proc Soc Exp Biol Med 158: 242-244, 1978.

311. Weinstock, M., Zavadil, A.P., Rosin, A.J., Chiueh, C.C. and Kopin, I.J.: The role of peripheral catecholamines in oxotremorine tremor in the rat and its antagonism by beta adrenoceptor blocking agents. J Pharmacol Exp Ther 206: 91-96, 1978.

312. Kopin, I.J.: Section I Summary - Birth Defects: Original article series. In Bergsma, D. and Goldstein, A. (Eds.): Neurochemical and Immunologic Components in Schizophrenia, Vol. XIV. Alan R. Liss, Inc., New York, 1978 (pp 75-77).

32

313. Chiueh, C.C. and Kopin, I.J.: Radioenzymatic paper-chromatographic assay for dopamine and norepinephrine in cerebroventricular cisternal perfusate of cat following administration of cocaine or d-amphetamine. J Neurochem 31: 561-564, 1978.

33

314. Gottesfeld, Z., Kvetnansky, R., Kopin, I.J. and Jacobowitz, D.M.: Effects of repeated immobilization stress on glutamate decarboxylase and Choline acetyltransferase in discrete brain regions. Brain Res 152: 374-378, 1978.

315. Kopin, I.J.: The role of calcium in neurosecretion. In Deniker, P., Radouco-Thomas, C., Villeneuve, A., Baronet-Lacroix, D. and Garcin, F. (Eds.): Neuropsychopharmacology, Vol 1. Pergamon Press, New York 1978 (pp. 357-361).

316. Kvetnansky, R., Kopin, I.J. and Saavedra, J.M.: Changes in epinephrine in individual hypothalamic nuclei after immobilization stress. Brain Res. 155: 387-390, 1978.

317. McCarty, R. and Kopin, I.J.: Sympatho-adrenal medullary activity and behavior during exposure to footshock stress: A comparison of seven rat strains. Physiol Behav 21: 567-572, 1978.

318. Kvetnansky, R., Sun, C.L., Lake, C.R., Thoa, N., Torda, T. and Kopin, I.J.: Effect of handling and forced immobilization on rat plasma levels of epinephrine, norepinephrine, and dopamine-ß-hydroxylase. Endocrinology 103: 1868-1874, 1978.

319. Rapoport, J.L., Mikkelsen, E.J., Ebert, M.H., Brown, G.L., Weise, V.K. and Kopin, I.J.: Urinary catecholamines and amphetamine excretion in hyper-active and normal boys. J Nerv Ment Dis 166: 731-737, 1978.

320. Elchisak, M.A., Polinsky, R.J., Ebert, M.H., Powers, K.J. and Kopin, I.J.: Contribution of plasma homovanillic acid (HVA) to urine and cerebrospinal fluid HVA in the monkey and its pharmacokinetic disposition. Life Sci 23: 2339-2348, 1978.

321. McCarty, R., Kvetnansky, R., Lake, C.R., Thoa, N.B. and Kopin, I.J.: Sympatho-adrenal activity of SHR and WKY rats during recovery from forced immobilization. Physiol Behav 21: 951-955, 1978.

322. McCarty, R. and Kopin, I.J.: Changes in plasma catecholamines and behavior of rats during the anticipation of footshock. Horm Behav 11: 248-257, 1978.

1979

323. Kopin, I.J.: Plasma catecholamines in human and experimental hyper-tension. In Meyer, P. and Schmitt, H. (Eds.): Nervous System and Hyper-tension. John Wiley & Sons, New York, 1979 (pp. 267- 276).

324. Saavedra, J.M., Kvetnansky, R. and Kopin, I.J.: , noradrenaline and dopamine levels in specific brain stem areas of acutely immobilized rats. Brain Res 160: 271-280, 1979.

325. Weinstock, M., Zavadil, III, A.P., Chiueh, C.C. and Kopin, I.J.: The effect of oxotremorine on blood pressure and plasma catecholamines in conscious and anesthetized rats. Life Sci 24: 301-310, 1979.

34

326. Kopin, I.J.: Biochemical assessment of peripheral adrenergic activity. In Paton, D.M. (Ed.): The Release of Catecholamines from Adrenergic Neurons. Pergamon Press, New York, 1979 (pp. 355- 372).

327. Tizabi, Y., Thoa, N.B., Maengwyn-Davies, G.M., Kopin, I.J. and Jacobowitz, D.M.: Behavioral correlation of catecholamine concentration and turnover in discrete brain areas of three strains of mice. Brain Res 166: 199-205, 1979.

328. Lake, C.R., Davis, P.B., Zeigler, M. and Kopin, I.J.: Electrolytes and norepinephrine levels in blood of patients with cycstic fibrosis. Clin Chim Acta 92: 141-146, 1979.

329. Kvetnansky, R., McCarty, R., Thoa, N.B., Lake, C.R., and Kopin, I.J.: Sympatho-adrenal responses of spontaneously hypertensive rats to immobilization stress. Am J Physiol 236: H457-H462, 1979.

330. Elchisak, M.A., Polinsky, R.J., Ebert, M.H., Modlin, L.T. and Kopin, I.J.: Kinetics of homovanillic acid and determination of its production rate in the rhesus monkey. Life Sci 24: 1493-1501, 1979.

331. Brown, G.L., Hunt, R.D., Ebert, M.H., Bunney, Jr., W.E. and Kopin, I.J.: Plasma levels of d-amphetamine in hyperactive children. Serial behavior and motor responses. Psychopharmacology 62: 133- 140, 1979.

332. McCarty, R. and Kopin, I.J.: Patterns of behavioral development in spontaneously hypertensive rats and Wistar-Kyoto normotensive controls. Dev Psychobiol 12: 239-243, 1979.

333. Kvetnansky, R., Weise, V.K., Thoa, N.B. and Kopin, I.J.: Effects of chronic guanethidine treatment and adrenal medullectomy on plasma levels of catecholamines and corticosterone in forcibly immobilized rats. J Pharmacol Exp Ther 209: 287-291, 1979.

334. Lake, C.R., Ziegler, M.G., Coleman, M. and Kopin, I.J.: Evaluation of the sympathetic nervous system in trisomy-21 (Down’s Syndrome). J Psychiatr Res 15: 1-6, 1979.

335. Sun, C.L., Thoa, N.B. and Kopin, I.J.: Comparison of the effects of 2-deoxyglucose and immobilization on plasma levels of catecholamines and corticosterone in awake rats. Endocrinology 105: 306-311, 1979.

336. McCarty, R., Giland, G.M., Weise, V.K. and Kopin, I.J.: Strain differences in rat adrenal biosynthetic enzymes and stress-induced increases in plasma catecholamines. Life Sci 25: 747- 754, 1979.

337. Kvetnansky, R., Kopin, I.J. and Klein, D.C.: Stress increases pineal epinephrine. Psychopharmacol Commun 3: 69-72, 1979.

338. Gilad, G.M., Gilad, V.H. and Kopin, I.J.: Reaction of the mutant mouse nude to axonal injuries of the central nervous system. Exp Neurol 65: 87-98, 1979.

35

339. Kopin, I.J.: Plasma catecholamines: A brief overview. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol 1. Pergamon Press, New York, 1979 (pp. 897-902).

340. Sun, C.L. and Kopin, I.J.: Plasma catecholamines and direct stimulation of rat hypothalamus. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol 2. Pergamon Press, New York, 1979. (pp. 1422- 1424).

341. Sisak, M.E., Markey, S.P., Colburn, R.W., Zavadil, A.P. and Kopin, I.J.: Identification of 6-hydroxymelatonin in normal human urine by gas chromatography-mass spectrometry. Life Sci 25: 803-806, 1979.

342. Yamaguchi, I. and Kopin, I.: Plasma catecholamine and blood pressure responses to sympathetic stimulation in pithed rats. Am J Physiol 237(3): H305-H310, 1979.

343. Gilad, G.M., McCarty, R., Weise, V.K. and Kopin, I.J.: Strain differences in the regulation of the sympatho-adrenal system. Brain Res 176: 380-384, 1979.

344. Kim, Y.D., Lake, C.R., Lees, D.E., Schuette, W.H., Bull, J.M., Weise, V.K., and Kopin, I.J.: Hemodynamic and plasma catecholamine responses to hyperthermic cancer therapy in humans. Am J Physiol 237(5): H570-H574, 1979.

345. Lake, C.R., Ziegler, M., Coleman, M.D. and Kopin, I.J.: Plasma levels of norepinephrine and dopamine-ß-hydroxylase in CRF patients treated with dialysis. Cardiovasc Med 4(10): 1099-1111, 1979.

346. McCarty, R. and Kopin, I.J.: Stress-induced alterations in plasma catechol-amines and behavior of rats: Effects of chlorisondamine and bretylium. Behav Neural Biol 27: 249-265, 1979.

347. Kvetnansky, R., Weise, V.K. and Kopin, I.J.: The origins of plasma epinephrine, norepinephrine and dopamine levels in stressed rats. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catechol-amines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New York, 1979 (pp. 684-686).

348. Ebert, M., Elchisak, M., Zavadil, A., Polinsky, R. and Kopin, I.J.: Use of deuterium- labelled methionine and HVA to study dopamine metabolism in vivo. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New York, 1979 (pp. 889-891).

349. Grobecker, H., Saavedra, J.M., McCarty, R., Weise, V.K. and Kopin, I.J.: Role of noradrenergic nerves and adrenal medulla during the development of genetic and experimental hypertension in rats. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New York, 1979 (pp. 906-908).

350. Yamaguchi, I., and Kopin, I.J.: Direct stimulation of sympathetic outflow and plasma levels of norepinephrine and epinephrine of pithed rats. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New York, 1979 (pp. 924-926).

36

351. Jimerson, D.C., Sun, C.L., Yamaguchi, I. and Kopin, I.J.: Plasma levels of glycol metabolites and presynaptic metabolism of nore-pinephrine (NE). In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New York, 1979 (pp. 927-929).

352. McCarty, R. and Kopin, I.J.: Plasma catecholamines and behavior of rats during stress. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 2. Pergamon Press, New York, 1979 (pp. 1789-1791).

353. Blombery, P., Kopin, I.J., Gordon, E.K. and Ebert, M.H.: Metabolism and turnover of MHPG in the monkey. In Usdin, E., Kopin, I.J., and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 2. Pergamon Press, New York, 1979 (pp. 1875-1877).

354. Markey, S.P., Powers, K. Dubinsky, D. and Kopin, I.J.: General methods for the synthesis of methyl isotope labelled catecholamine metabolites. Preparation of 4-hydroxy-3- methoxy-d3-mandelic acid, phenylacetic acid, and phenylethylene glycol. Journal Labelled Compounds Radiopharma-ceuticals 17(1): 103-113, 1979.

355. Weinstock, M., Zavadil, III, A.P. and Kopin, I.J.: Differential effects of d-and 1- propranolol on dopamine turnover stimulated by oxotremorine in striatal and mesolimbic areas of rat brain. Eur J Pharmacol 59(3-4): 187-193, 1979.

356. McCarty, R., Chiueh, C.C., and Kopin, I.J.: Differential behavioral responses of spontaneously hypertensive (SHR) and normotensive (WKY) rats to d-amphetamine. Pharmacol Biochem Behav 12: 53-59, 1979.

357. Gilad, G.M. and Kopin, I.J.: Neurochemical aspects of neuronal ontogenesis in the developing rat cerebellum: Changes in neuro-transmitter and polyamine synthesizing enzymes. J Neurochem 33: 1195-1204, 1979.

358. Gross, H.A., Lake, C.R., Ebert, M.H., Ziegler, M.G., and Kopin, I.J.: Catecholamine metabolism in primary anorexia nervosa. J Clin Endocrinol Metab 49(6): 805-809, 1979.

359. Markey, S.P., Colburn, R.W., Kopin, I.J., and Aamodt, R.L.: Distribution and excretion in the rat and monkey of 82Br Bromocriptine. J Pharmacol Exp Ther 211: 31-35, l979.

360. Lake, C.R., Ziegler, M.G., Coleman, M.D. and Kopin, I.J.: Hydro-chlorothiozide-induced sympathetic hyperactivity in hypertensive patients. Clin Pharmacol Ther 26:4: 428-432, 1979.

361. Davis, G.C., Williams, A.C., Markey, S.P., Ebert, M.H., Caine,-E.D., Reichert, C.M. and Kopin, I.J.: Chronic parkinsonism-secondary to intravenous injection in meperidine analogues.-- Psychiatry Res 1: 249-254, 1979.

1980

37

362. Kopin, I.J., McCarty, R., Torda, T. and Yamaguchi, I.: Catechol-amines in plasma and responses to stress. In Usdin, E., Kvetnansky, R. and Kopin, I.J. (Eds.): Catecholamines and Stress: Recent Advances, Vol 8. New York, Elsevier/North Holland, 1980, pp. 197-204.

363. Lake, C.R., Sternberg, D.E., VanKammen, D.P., Ballenger, J.C., Ziegler, M.G., Post, R.M., Kopin, I.J. and Bunney, W.E.: Schizo-phrenia: Elevated cerebrospinal fluid norepinephrine. Science 207: 331-333, 1980.

364. Gilad, G.M., Gagnon, C., and Kopin, I.J.: Protein carboxymethylase activity in the rat superior cervical ganglion during development and after axonal injury. Brain Res 183: 393- 402, 1980.

365. Yamaguchi, I. and Kopin, I.J.: Blood pressure, plasma catechol-amines and sympathetic outflow in pithed SHR and WKY rats. Am Physiol Soc 238: (Heart Circ Physiol 7): H365- H372, 1980.

366. Tetsuo, M., Markey, S.P., and Kopin, I.J.: Measurement of 6-hydroxy-melatonin in human urine and its diurnal variations. Life Sci 27: 105-109, 1980.

367. Yamaguchi, I. and Kopin, I.J.: Differential inhibition of Alpha-1 and Alpha-2 adrenoceptor-mediated pressor responses in pithed rats. J Pharmacol Exp Ther 214: 275-281, 1980.

368. Lake, C.R., Ziegler, M.G., Coleman, M.D., and Kopin, I.J.: Fen-fluramine potentiation of anti-hypertensive effects of thiazides. Clin Pharmacol Ther 28: 22-27, 1980.

369. Oertel, W.H., Tappaz, M.L., Kopin, I.J., Ransom, D.H., and Schmechel, D.E.: Production of an antiserum to rat brain glutamate (GAD)/cysteine sulfinate (CSD) decarboxylase. Brain Res Bull 5(2): 713-719, 1980.

370. Kopin, I.J., McCarty, R., and Yamaguchi, I.: Plasma catecholamines in human and experimental hypertension. Clin Exp Hypertens 2(3&4): 379-394, 1980.

371. Blombery, P.A., Kopin, I.J., Gordon, E.K., Markey, S.P. and Ebert, M.H.: Conversion of MHPG to . Arch Gen Psychiatry 37: 1095-1098, 1980.

372. Oertel, W.H., Schmechel, D.E., Daly, J.W., Tappaz, M.L. and Kopin, I.J.: Localization of glutamate decarboxylase on line-immunoelectro-phoresis and two-dimensional electrophoresis by use of the radioactive suicide substrate [2-3H]-y-acetylenic GABA. Life Sci 27: 2133-2141, l980.

373. Fuerstein, G., Torda, T. and Kopin I.J.: Effect of indomethacin on cardiac --adrenergic receptors. Eur J Pharmacol 67: 469-472, 1980.

374. Polinsky, R.J., Kopin, I.J., Ebert, M.H. and Weise, V.: Pharmacologic distinction of different orthostatic hypotension syndromes. Neurology 31: 1-7, 1980.

38

375. Lake, C.R., Polinsky, R.J., Gullner, H.G., Ebert, M.H., Ziegler, M.G., Barter, F.C. and Kopin, I.J.: Dissociation between central and peripheral noradrenergic activity in essential hypertension. Clin Sci 59: 229-233, 1980.

376. Weinstock, M., Zavadil, A.P., Muth, E.A., Crowley, W.R., O’Donohue, T.L., Jacobowitz, D.M. and Kopin, I.J.: Evidence that noradrenaline modulates the increase in striatal dopamine metabolism induced by muscarinic receptor stimulation. Eur J Pharmacol 68: 427-435, 1980.

377. Polinsky, R.J., Kopin, I.J., Ebert, M.H. and Weise, V.: The adrenal medullary response to hypoglycemia in patients with orthostatic hypotension. J Clin Endocrinol Metab 51(6): 1401- 1406, l980.

1981

378. Eisler, T., Teravainen, H., Nelson, R., Krebs, H., Weise, V., Lake, C.R., Ebert, M.H., Whetzel, N., Murphy, D.L., Kopin, I.J. and Calne, D.B.: Deprenyl in Parkinson Disease. Neurology 31: 19-23, 1981.

379. Tetsuo, M., Markey, S.P., Colburn, R.W. and Kopin, I.J.: Quantitative analysis of 6- hydroxymelatonin in human urine by gas chromatography-negative chemical ionization mass spectrometry. Anal Biochem 110: 208-215, 1981.

380. Torda, T., Yamaguchi, I., Hirata, F., Kopin, I.J. and Axelrod, J.: Mepacrine treatment prevents immobilization-induced desensi-tization of beta-adrenergic receptors in rat hypothalmus and brain stem. Brain Res 205: 441-444, 1981.

381. Elkins, R.N., Rapoport, J.L., Zahn, T.P., Buchsbaum, M.S., Weingartner, H., Kopin, I.J., Langer, D. and Johnson, C.: Acute effects of caffeine in normal prepubertal boys. Am J Psychiatry 138(2): 178-183, 1981.

382. Goldstein, D.S., Feuerstein, G., Izzo, J.L., Kopin, I.J. and Keiser, H.,R.: Validity and reliability of liquid chromatography with electro-chemical detection for measuring plasma levels of norepinephrine and epinephrine in man. Life Sci 28: 467-475, 1981.

383. McCarty, R., Kvetnansky, R. and Kopin, I.J.: Plasma catecholamines in rats: Daily variations in basal levels and increments in response to stress. Physiol Behav 26: 27-31, 1981.

384. Torda, T., Yamaguchi, I., Hirata, F., Kopin, I.J. and Axelrod, J.: Quinacrine-blocked desensitization of adrenoceptors after immobilization stress or repeated injection of isoproterenol in rats. J Pharmacol Exp Ther 216(2): 334-338, 1981.

39

385. Feuerstein, G. and Kopin, I.J.: Effect of PGD2, PGE2, PGF2-, and PGI2 on blood pressure, heart rate and plasma catecholamine responses to spinal cord stimulation in the rat. Prostaglandins 21(2): 189-206, 1981.

386. Feuerstein, G., Jimerson, D.C. and Kopin, I.J.: Prostaglandins, catecholamines, and cardiovascular responses to hemorrhage. Am J Physiol 240: R166-R174, 1981.

387. Feuerstein, G., Adelberg, S.A., Kopin, I.J. and Jacobowitz, D.M.: Cardio-vascular and sympathetic responses to PGF2- injection into hypothalamus nuclei. Brain Res Bull 6: 203-207, 1981.

388. Feuerstein, G., Yamaguchi, I., and Kopin, I.J.: Effect of GABA agonist and antagonists on cardiovascular and sympathetic responses in SHR and WKY rats. Clin Exp Hypertens 3(2): 207-218, 1981.

389. Kopin, I.J.: Catecholamines and blood pressure regulation. In Soffer, R.N. (Ed.): Biochemical Regulation of Blood Pressure. John Wiley & Sons, 1981 (pp. 266-279).

390. Tappaz, M.L., Aguera, M., Belin, M.F., Oertel, W.H., Schmechel, D.E., Kopin, I.J., and Pujol, J.F.: GABA markers in the hypo-thalamic median eminence. In Costa, E., DiChiara, G., and Gessa, G.L. (Eds.): GABA and Benzodiazepine Receptors. New York, Raven Press, 1981 (pp. 229-236).

391. Yamaguchi, I., Torda, T., Hirata, F. and Kopin, I.J.: Adrenoceptor desensitization after immobilization stress or repeated injection of isoproterenol. Am J Physiol 240: (Heart Circ. Physiol. 9:) H691-H696, 1981.

392. Kopin, I.J., Goldstein, D.S. and Feuerstein, G.Z.: Position Paper: The Sympathetic Nervous System and Hypertension. In Laragh, J.J., Buhler, F.R. and Seldin, D.W. (Eds.): Frontiers in Hypertension Research. New York, Springer-Verlag, 1981 (pp. 283- 289).

393. Jimerson, D.C., Markey, S.P., Oliver, J.A. and Kopin, I.J.: Simultaneous measurement of plasma 4-hydroxy-3-methoxyphenyl-ethylene glycol and 3,4-dihydroxyphenylethylene glycol by gas chromatography mass spec-trometry. Biomed Mass Spectrom 8(6): 256-259, 1981.

394. Kopin, I.J.: Mode of action of antidepressants and central stimulants. In van Praag, H.M., Lader, M.H., Rafaelsen, O.J., and Sachar, E.J. (Eds.): Handbook of Biological Psychiatry - Part IV Brain Mechanisms and Abnormal Behavior. New York, Marcel Dekker 1981 (pp. 741-766).

395. Oertel, W.H., Schmechel, D.E., Brownstein, M.J., Tappaz, M.L., Ransom, D.H. and Kopin, I.J.: Decrease of glutamate decarboxylase (GAD)-immuno-reactive nerve terminals in the substantia nigra after kainic acid lesion of the striatum. J Histochem Cytochem 29(8): 977-980, 1981.

396. Zerbe, R.L., Feuerstein, G. and Kopin, I.J.: Effect of captopril on cardio-vascular, sympathetic and vasopressin responses to hemorrhage. Eur J Pharmacol 72: 391-395, 1981.

40

397. Tetsuo, M., Polinsky, R.J., Markey, S.P. and Kopin, I.J.: Urinary 6-hydroxymelatonin excretion in patients with orthostatic hypotension. J Clin Endocrinol Metab. 53: 607, 1981.

398. Polinsky, R.J., Kopin, I.J., Ebert, M.H., Weise, V. and Recant, L.: Hormonal responses to hypoglycemia in orthostatic hypotension patients with adre-nergic insufficiency. Life Sci 29: 417-425, 1981.

399. Kopin, I.J.: Assessing norepinephrine metabolism in human brain: Past, present, and future. In Matthysse, S. (Eds.): Psychiatry and the Biology of the Human Brain. New York, Elsevier North Holland, 1981 (pp. 89-101)

400. Saller, C.F. and Kopin, I.J.: Glucose potentiates haloperidol induced catalepsy. Life Sci 29(22): 2337-2342, 1981.

401. Feuerstein, G., DiMicco, J.A., Ramu, A. and Kopin, I.J.: Effect of indomethacin on the blood pressure and plasma CA responses to acute endotoxaemia. J Pharm Pharmacol 33: 576- 579, 1981.

402. Helke, C.J., DiMicco, J.A., Jacobowitz, D.M. and Kopin, I.J.: Effect of capsaicin administration to neonatal rats on the Substance P content of discrete CNS regions. Brain Res 222: 428-431, 1981.

403. Feuerstein, G., Chiueh, C.C. and Kopin, I.J.: Effect of naloxone on the cardiovascular and sympathetic response to hypovolemic hypotension in the rat. Eur J Pharmacol 75: 65-69, 1981.

404. Feuerstein, G., Adelberg, S., Kopin, I.J. and Jacobowitz, D.M.: Central cardiovascular effects of prostacyclin. Neuropharmacology, 20: 1085-1090, 1981.

405. Lozovsky, D., Saller, C. and Kopin, I.J.: Dopamine receptor binding is increased in diabetic rats. Science 214: 1031-1032, 1981.

406. Feuerstein, G., Zukowska-Grojec, Z. and Kopin, I.J.: Cardiovascular effects of leukotriene D4 in SHR and WKY rats. Eur J Pharmacol 76: 107-110, 1981.

407. Kopin, I.J.: Neurotransmitters and the Lesch Nyhan Syndrome. N Engl J Med 305: 1148- 1150, 1981.

408. Jimerson, D.C., Nurnberger, J.I., Post, R.M., Gershon, E.S. and Kopin, I.J.: Plasma MHPG in rapid cyclers and healthy twins. Arch Gen Psychiatry 38: 1287-1290, 1981.

409. Oertel, W.H., Schmechel, D.E., Weise, V.K., Ransom, D.H., Tappaz, M.L., Krutzsch, H.C. and Kopin, I.J.: Comparison of cycteine sulphinic acid decarboxylase isoenzymes and glutamic acid decar-boxylase in rat liver and brain. Neuroscience 6(12): 2701-2714, 1981.

410. Oertel, W.H., Schmechel, D.E., Mugnaini, E., Tappaz, M.L. and Kopin, I.J.: Immunocytochemical localization of glutamate decar-boxylase in rat cerebellum with a new antiserum. Neuroscience 6(12): 2715-2735, 1981.

41

411. Oertel, W.H., Schmechel, D.E., Tappaz, M.L. and Kopin, I.J.: Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex. Neuro-science 6(12): 2689-2700, 1981.

412. Feuerstein, G., Zerbe, R.L., Ben-Ishay, D., Kopin, I.J. and Jacobowitz, D.M.: Catecholamines and vasopressin in forebrain nuclei of hypertension prone and resistant rats. Brain Res Bull 7: 671-676, 1981.

413. Kopin, I.J.: False transmitters revisited: Their role in the hypotensive action of MAO inhibitors. In Kamijo, K., Usdin, E. and Nagatsu, T. (Eds.): Monamine Oxidase. Basic and Clinical Frontiers. Amsterdam-Oxford-Princeton, Excerpta Medica 1981 (pp. 321-327).

42

413a Kim, Y.D., Jones, M., Hanowell, S.T., Koch, J.P., Lees, D.E., Weise, V. and Kopin, I.J.: Changes in peripheral vascular and cardiac sympathetic activity before and after coronary artery bypass surgery: Interrelationships with hemodynamic alterations. Am Heart J 102(6): 972-979, 1981.

1982

414. Feuerstein, G., Adelberg, S.A., Kopin, I.J. and Jacobowitz, D.M.: Hypothalamic sites for cardiovascular and sympathetic modulation by prostaglandin E2. Brain Res 231: 335-342, 1982. 415. Elchisak, M.A., Polinsky, R.J., Ebert, M.H. and Kopin, I.J.: Kinetics of homovanillic acid and determination of its production rate in humans. J Neurochem 38: 380-385, 1982.

416. Feuerstein, G., Zerbe, R.L., Meyer, D.K. and Kopin, I.J.: Alteration of cardiovascular, neurogenic and humoral responses to acute hypovolemic hypotension by administered prostacyclin. J Cardiovasc Pharmacol 4: 246-253, 1982.

417. Oertel, W.H., Mugnaini, E., Tappaz, M.L., Weise, V.K., Dahl, A.L., Schmechel, D.E. and Kopin, I.J.: Central GABAergic innervation of neurointermediate pituitary lobe: Biochemical and Immunocytochemical study in the rat. Neurobiology 79: 675-679, 1982.

418. Polinsky, R.J., Taylor, I.L., Weise, V., and Kopin, I.J.: Pancreatic polypeptide responses to hypoglycemia in chronic autonomic failure: J Clin Endocrinol Metab 54: 48-52, 1982.

419. Feuerstein, G., Helke, C.J., Zerbe, R.L., Jacobowitz, D.M. and Kopin, I.J.: Mechanisms involved in central cardiovascular effects of prostaglandin F2. Am J Physiol 242: (Regulatory Integrative Comp Physiol 11): R545-R551, 1982.

420. Cohen, R.M., Campbell, I.C., Yamaguchi, I., Pickar, D. and Kopin, I.J.: Cardiovascular changes in response to selective monoamine oxidase inhibition in the rat. Eur J Pharmacol 80: 155-160, 1982.

421. Oertel, W.H., Mugnaini, E., Schmechel, D.E., Tappaz, M.L. and Kopin, I.J.: The immunocytochemical demonstration of Gamma-aminobutyric acid-ergic neurons -- Methods and Application. Chan-Palay,V. and Palay, S.L. (Eds.): Cytochemical Methods in Neuroanatomy. New York, Liss, Inc. 1982 (pp. 297-329).

422. Feuerstein, G., Zukowska-Grojec, Z., Krausz, M.M., Blank, M.L., Snyder, F. and Kopin, I.J.: Cardiovascular and sympathetic effects of 1-0-hexadecyl-2-acetyl-sn-glycero-3- phosphocholine in conscious SHR and WKY rats. Clin Exper Hypertens--A- 4(8): 1335-1350, 1982.

423. Bybee, D.E., Wiesen, M., Aronin, N., Krieger, D.T., Frohman, L.A. and Kopin, I.J.: Failure of bromocriptine to lower plasma catecholamines in normal men and women. J Clinl Endocrinol Metab 53(3): 648-650, 1982.

424. Poddubiuk, Z.M., Blumberg, J.B. and Kopin, I.J.: Brain prosta-glandin content in rats sacrificed by decapitation vs focused microwave irradiation. Experientia 15(38): 987-988, 1982.

43

425. Zerbe, R.L., Feuerstein, G., Meyer, D.K. and Kopin, I.J.: Cardio-vascular, sympathetic, and renin-angiotensin system responses to hemorrhage in vasopressin-decifient rats. Endocrinology III(2): 608-613, 1982.

426. Feuerstein, G., Zerbe, R., Ben-ishay, D., Kopin, I.J. and Jacobowitz, D.M.: Catecholamines and vasopressin hindbrain nuclei of hyper-tension prone and resistant rats. Brain Res 251: 169-173, 1982.

427. Saller, C., Zerbe, R., Bayorh, M., Lozovsky, D. and Kopin, I.J.: Phencyclidine suppresses plasma prolactin levels. Eur J Pharmacol 83: 309-311, 1982.

428. Zukowska-Grojec, Z., Bayorh, M., Kopin, I.J. and Feuerstein, G.: Leukotriene D4: Cardiovascular and sympathetic effects in spon-taneously hypertensive rats (SHR) and Wistar- Kyoto (WKY) rats. J Pharmacol Exp Ther 223: 183-189, 1982.

429. Bayorh, M. and Kopin, I.J.: Effect of phencyclidine (PCP) on adrenergic responses to spinal cord stimulation in pithed rats. Eur J Pharmacol 85: 15-21, 1982.

430. Kopin, I.J.: Evolving views of the metabolic fate of norepine-phrine. Endocrinol Exp 16: 291-300, 1982.

431. Linnoila, M., Karoum, F., Calib, H.M., Kopin, I.J. and Potter, W.Z.: Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients. Arch Gen Psychiatry 39: 1025-1028, 1982.

432. Pfeiffer, A., Feuerstein, G., Faden, A.I. and Kopin, I.J.: Evidence for an involvement of - but not delta or kappa opiate receptors in sympa-thetically and parasympathetically mediated cardiovascular responses to opiate upon intra-hypothalamic microinjection. Life Sci 31: 1279- 1282, 1982. 1983

433. Kopin, I.J., Gordon, E.K., Jimerson, D.C. and Polinsky, R.J.: Relation between plasma and cerebrospinal fluid levels of 3-methoxy-4-hydroxy-phenyl-glycol. Science 219: 73-75, 1983.

434. Jimerson, D.C., Insel, T.R., Reus, V.I. and Kopin, I.J.: Increased plasma MHPG in dexamethasone-resistant depressed patients. Arch Gen Psychiatry 40: 173-176, 1983.

435. Bayorh, M.A., Zukowska-Grojec, Z. and Kopin, I.J.: Effect of Desipramine and cocaine on plasma norepinephrine and pressor responses to adrenergic stimulation in pithed rats. J Clin Pharmacol 23: 24-31, 1983.

436. Zerbe, R.L., Bayorh, M.A., Quirion, R. and Kopin, I.J.: The role of vasopressin suppression in phencyclidine-induced diuresis. Pharmacology 26: 73-78, 1983.

44

437. Zukowska-Grojec, Z., Bayorh, M.A., Yaar, I., Kopin, I.J. and Feuerstein, G.: Lukotriene D4: Divergent cardiovascular and sympathetic effects in spon-taneously hypertensive and normotensive Wistar-Kyoto rats. Adv Prostaglandin Thromboxane Res 11: 407-412, 1983.

438. Martin, P.R., Ebert, M.H., Gordon, E.K. and Kopin, I.J.: Urinary catecholamine metabolites and effects of clonidine in patients with alcohol amnestic disorder. Clin Pharmacol Ther 33(1): 19-27, 1983.

439. Bayorh, M.A., Zukowska-Grojec, Z., Ezra, D., Feuerstein, G.Z. and Kopin, I.J.: Cardiovascular and sympathetic responses to chronic arachidonate in SHR and WKY rats. Hypertension 5: 172-179, 1983.

440. Zukowska-Grojec, Z., Bayorh, M.A. and Kopin, I.J.: Effect of desipramine on the effects of --adrenoceptor inhibitors on pressor responses and release of norepinephrine into plasma of pithed rats. J Cardiovasc Pharmacol 5: 297-301, 1983.

441. Lozovsky, D., Saller, C.F., Bayorh, M.A., Chiueh, C.C., Rice, K.C., Burke, T.R., Jr. and Kopin, I.J.: Effects of phencyclidine on rat prolactin, dopamine receptor and locomotor activity. Life Sci 32: 2725-2731, 1983.

442. Lozovsky, D., Saller, C.F. and Kopin, I.J.: Lithium and the prevention of dopamine receptor supersensitivity in diabetic rats. Am J Psychiatry 140(5): 613-614, 1983.

443. Goldstein, D.S., Lake, C.R., Chernow, B., Ziegler, M.G., Coleman, M.D., Taylor, A.A., Mitchell, J.R., Kopin, I.J. and Keiser, H.R.: Age-dependence of hypertensive-normotensive differences in plasma norepinephrine. Hypertension 5: 100-104, 1983.

444. Chiueh, C.C., Zukowska-Grojec, Z., Kirk, K.L. and Kopin, I.J.:6-Fluorocatecholamines as false adrenergic neurotransmitters. J Pharmacol Exp Ther 225: 529-533, 1983.

445. Burns, R.S., Chiueh, C.C., Markey ,S.P., Ebert, M.H., Jacobowitz, D.M. and Kopin, I.J.: A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 80: 4546-4550, 1983.

446. Polinsky, R.J., Samaras, G.M., and Kopin, I.J.: A sympathetic neural prosthesis for managing orthostatic hypotension. Lancet 1: 901-904, 1983.

447. Goldstein, D.S., McCarty, R., Polinsky, R.J. and Kopin, I.J.: Relationship between plasma norepinephrine and sympathetic neural activity. Hyper-tension 5: 552-558, 1983.

448. Oertel, W.H., Graybiel, A.M., Mugnaini, E., Elde, R.P., Schmechel, D.E. and Kopin, I.J.: Coexistence of glutamic acid decarboxylase- and somatostatin-like immunoreactivity in neurons of the feline nucleus retricularis thalami. J Neurosci 3(6): 1322-1332, 1983.

449. Kopin, I.J., Polinsky, R.J., Oliver, J.A., Oddershede, I.R. and Ebert, M.H.: Urinary catecholamine metabolites distinguish different types of sympathetic neuronal dysfunction in patients with orthostatic hypotension. J Clin Endocrinol Metab 57(3): 632- 637, 1983.

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450. Williford, D.J., Zavadil, A.P., Walsh, R.A., Weise, V., Kopin, I.J. and Gillis, R.A.: Influence of vagotomy on changes in feline plasma catecholamine levels induced by occlusion of either the left or right coronary vessel. Cardiovas Res 17: 568-576, 1983.

451. Zukowska-Grojec, Z., Bayorh, M.A., Zerbe, R.L., Palkovits, M. and Kopin, I.J.: Role of catecholamines and vasopressin in cardio-vascular responses to bilateral dorsolateral transection of the medulla oblongata in the rat. Hypertension 5(6): 908-915, 1983.

452. Jimerson, D.C., Rubinow, D.R., Ballenger, J.C., Post, R.M. and Kopin, I.J.: Peripheral contribution to cerebrospinal fluid MHPG: Studies in depressed patients. Psychopharmacol Bull 19(4): 665-668, 1983.

453. Pfeiffer, A., Feuerstein, G., Kopin, I.J. and Faden, A.I.: Cardio-vascular and respiratory effects of Mu-, Delta- and Kappa-opiate agonists micro-injected into the anterior hypothalamic brain area of awake rats. J Pharmacol Exper Ther 225(3): 735-741, 1983.

454. Pfeiffer, A., Feuerstein, G., Zerbe, R.L., Faden, A.I. and Kopin, I.J.: m-Receptors mediate opioid cardiovascular effects at anterior hypothalamic sites through sympatho-adrenomedullary and parasympathetic pathways. Endocrinology 113(3): 929-938, 1983.

455. Zukowska-Grojec, Z., Bayorh, M., Faden, A.I., Kopin, I.J. and Feuerstein, G.: Pharmacological intervention in the cardiovascular effects of leukotriene D4 in pithed spontaneous hypertensive rats. In Piper, P.J. (Ed.): Leukotrienes and Other Lipoxygenase Products. Chichester, England, John Wiley and Sons, 1983 (pp. 113-120).

456. Feuerstein, G., Zukowska-Grojec, Z., Bayorh, M., Kopin, I.J. and Faden, A.I.: Leukotriene D4-induced hypotension is reversed by thyrotropin-releasing hormone. Prostaglandins 26(5): 711-724, 1983.

457. Goldstein, D.S., Horwitz, D., Keiser, H.R., Polinsky, R.J. and Kopin, I.J.: Plasma --[3H]- norepinephrine, d-[14C]-norepinephrine, and d,-,-[3H]-isoproterenol - kinetics in essential hypertension. J Clin Invest 72: 1748-1758, 1983.

458. Bayorh, M.A., Lozovsky, D., Rice, K.C., Burke, T.R. Jr. and Kopin, I.J.: Cardio-vascular and plasma prolactin responses to stereoisomers of phencyclidine. Pharmacol Biochem Behav 19: 365-367, 1983.

459. Ezra, D., Bayorh, M.A., Zukowska-Grojec, Z., Lazar, J.D. and Kopin, I.J.: Effects of chronic arachidonate on blood pressure of spon-taneously hypertensive rats. Clin Exp Hypertens 5: 1485-1499, 1983.

460. Ross, R.J., Zavadil, A.P., Calil, H.M., Linnoila, M., Kitanaka, I., Blombery, P. and Kopin, I.J.: Effects of desmethylimipramine on plasma norepinephrine, pulse, and blood pressure. Clin Pharmacol Ther 33(4):-429-437, 1983.

1984

46

461. Angus, J.A., Bobik, A., Jackman, G.P., Kopin, I.J. and Korner, P.I.: Role of auto- inhibitory feed-back in cardiac sympathetic transmission assessed by simultaneous measurements of changes in [3H]-efflux and atrial rate in guinea-pig atrium. Br J Pharmacol 81: 201-214, 1984.

462. Kopin, I.J.: Plasma catecholamines as an index of a neuroendocrine response. In Shah, N.S. and Donald, A.G. (Eds.): Psychoneuro-endocrine Dysfunction. New York, Plenum Publishing Corporation, (pp. 157-171), 1984.

463. Martin, P.R., Weingartner, H., Gordon, E.K., Burns, R.S., Linnoila, M., Kopin, I.J. and Ebert, M.H.: Central nervous system catechol-amine metabolism in Korsakoff’s psychosis. Ann Neurol 15: 184-187, 1984.

464. Kopin, I.J.: Avenues of investigation for the role of catecholamines in anxiety. Psychopathology 17(1): 83-97, 1984.

465. Solomon, S.L., Wallace, E.M., Ford-Jones, E.L., Baker, M., Martone, W. J., Kopin, I.J., Critz, A.D. and Allen, J.R.: Medication errors with inhalant epinephrine mimicking an epidemic of neonatal sepsis. New Engl J Med 310: 166-170, 1984.

466. Kopin, I.J., Jimerson, D.C., Markey, S.P., Ebert, M.H. and Polinsky, R.J.: Disposition and metabolism of MHPG in humans: Application to studies in depression. Pharmacopsychiatry 17: 3-8, 1984.

467. Feuerstein, G., Bayorh, M.A., Zerbe, R.L. and Kopin, I.J.: Peripheral pressor effects of sympathetic stimulation, noradrenaline, angiotensin II and vasopressin in Brattleboro rats. Naunyn Schmiedebergs Arch Pharmacol 325: 247-250, 1984.

468. Martin, P.R., Ebert, M.H., Gordon, E.K. Linnoila, M. and Kopin, I.J.: Effects of clonidine on central and peripheral catecholamine metabolism. Clin Pharmacol Ther 35: 322-327, 1984.

469. Brown, R.T., Oliver, J., Kirk, K.L. and Kopin, I.J.: Determination of urinary 4-hydroxy- 3-methoxyphenylethylene glycol in man by high performance liquid chromatography with electrochemical detection. Life Sci 34: 2313-2318, 1984.

470. Ward, C.D., Trombley, I.K., Calne, D.B. and Kopin, I.J.: L-Dopa decarboxy-lation in chronically treated patients - Brief Communi-cations. Neurology 34: 198-201, 1984.

471. Kopin, I.J., Zukowska-Grojec, Z., Bayorh, M.A. and Goldstein, D.S.: Estimation of intrasynaptic norepinephrine concentrations at vascular neuroeffector junctions in vivo. Naunyn- Schmiedebergs Arch Pharmacol 325: 298-305, 1984.

472. Pfeiffer, A., Pfeiffer, D.G., Feuerstein, G., Faden, A.I. and Kopin, I.J.: An increase in opiate receptor-sites is associated with enhanced cardiovascular depressant, but not respiratory depressant action of morphine. Brain Res 296: 305-3ll, 1984.

473. Chiueh, C.C., Markey, S.P., Burns, R.S., Johannessen, J.N., Pert, A. and Kopin, I.J.: Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4- phenyl-1,2,3,6-tetrahydro-pyridine in the rat. Eur J Pharmacol 100: 189-194, 1984. 47

474. Kopin, I.J.: Catecholamines and the cardiovascular system: Recent advances in biochemical evaluation of adrenergic activity. In Usdin, E., Carlsson, A. Dahlstrom, A. and Engel, J. (Eds.): Catecholamines Part A: Basic and Peripheral Mechanisms. New York, Alan R. Liss, Inc. 1984, pp. 347-355.

475. Polinsky, R.J., Jimerson, D.C. and Kopin, I.J.: Chronic autonomic failure: CSF and plasma 3-methoxy-4-hydroxypenylglycol. Neurology 34: 979-983, 1984.

476. Kopin, I.J., Blombery, P., Ebert, M.H., Gordon, E.K., Jimerson, D.C., Markey, S.P. and Polinsky, R.J.: Disposition and metabolism of MHPG-CD3 in humans: Plasma MHPG as the principal pathway of norepinephrine metabolism and as an important determinant of CSF levels of MHPG. In Usdin, E., Sjoqvist, F. and Bertilsson, L. (Eds.): Frontiers in Biochemical and pharmacological Research in Depression. New York, Raven Press, 1984, 57-68.

477. Jimerson, D.C., Rubinow, D.R., Ballenger, J.C., Post, R.M. and Kopin, I.J.: Cerebrospinal fluid norepinephrine metabolites in depressed patients: New methodologies. In Usdin, E., Carlsson, A., Dahlstrom, A. and Engel, J. (Eds.): Catecholamines: Neuro- pharmacology and Central Nervous System -Therapeutic Aspects. New York, Alan R. Liss, Inc. 1984, pp. 123-129.

478. Kafka, M.S., Polinsky, R.J., Williams. A., Kopin, I.J., Lake, C.R., Ebert, M.H. and Tokola, N.S.: Alpha-adrenergic receptors in ortho-static hypotension syndromes. Neurology 34: 1121-1125, 1984.

479. Zamir, N., Bannon, M.J., Helke, C.J., Kopin, I.J. and Jacobowitz, D.M.: Primate Model of Parkinson’s Disease: alterations in multiple opioid systems in the basal ganglia. Brain Res 322:356-360, 1984.

480. Kopin, I.J.: Neurotransmitters and neuropsychopharmacology in Stetten, Jr., D., (Ed.) and Carrigan, W. T., (Assoc. Ed.), NIH: An Account of Research in its Laboratories and Clinics. New York, Academic Press, 1984, 34-45.

481. Angus, J.A., Korner, P.I., Jackman, G.P., Bobik, A. and Kopin, I.J.: Role of autoinhibitory feedback in cardiac sympathetic transmission. Clin Exp Hypertens (A) 6(1-2): 371-385, 1984.

482. DeQuattro, V., Sullivan, P., Minagawa R., Kopin, I., Bornheimer, J., Foti, A., and Barndt, R.: Central and peripheral noradrenergic tone in primary hypertension. Fed Proc 43(1): 47-51, 1984.

483. Chiueh, C.C., Burns, R.S., Markey, S.P., Jacobowitz, D.M. and Kopin, I.J.: Primate model of parkinsonism: Selective lesion of nigro-striatal neurons by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys: Life Sci 36: 213- 218, 1984.

484. Bayorh, M.A., Zukowska-Grojec, Z., Palkovits, M. and Kopin, I.J.: Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei. Brain Res 321: 315-318, 1984 48

485. Chiueh, C.C., Markey, S.P., Burns, R.S., Johannessen, J.N., Jacobowitz, D.M. and Kopin, I.J.: Selective neurotoxic effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in subhuman primates and man: A new animal model of parkinson’s disease. Psychopharmacol Bull 20: 548-553, 1984.

486. Zavadil, A.P., Ross, R.J., Calil, H.M., Linnoila, M., Blombery, P., Jimerson, D.C., Kopin, I.J. and Potter, W.Z.: The effect of desmethylimipramine on the metabolism of norepinephrine. Life Sci 35(10): 1061-1068, 1984.

487. Bayorh, M.H., Zukowska-Grojec, Z., Kopin, I.J. and Feuerstein, G: Leukotriene D4 inhibits cardiovascular responses to sympathetic stimu-lation, angiotensin and vasopressin in the pithed spontaneously hypertensive rat. J Pharmacol Exp Ther 231(1): 85-90, 1984.

488. Jacobowitz, D.M., Burns, R.S., Chiueh, C.C. and Kopin, I.J.: N-methyl-4- phenyl- 1,2,3,6-tetra-hydropyridine (MPTP) causes destruction of the nigrostriatal but not the mesolimbic dopamine system in the monkey. Psychopharmacol Bull, 20:(3):416-422, 1984.

489. Feuerstein, G., Lozovsky, D., Cohen, L.A., Labroo, V.M., Kirk, K.L., Kopin, I.J. and Faden, A.I.: Differential effect of fluorinated analogs of TRH on the cardiovascular system and prolactin release. Neuropeptides 4(4): 303-310, 1984.

1985

490. Zukowska-Grojec, Z., Zerbe, R.L., Jimerson, D.C., Bayorh, M.A., Palkovits, M. and Kopin, I.J.: Catecholaminergic activity of the baroreceptor areas of the brain in response to bilateral dorsolateral transection of medulla oblongata in rats. Brain Res 325: 231-240, 1985.

491. Kopin, I.J.: Biochemical evaluation of sympatho-adrenal medullary activity - An overview. In Ben-Jonathan, N., Bahr, J.M. and Weiner, R.I. (Eds): Catecholamines as hormone regulators, Vol. 18. Serono Symposia. New York, Raven Press, 1985, 175-188.

492. Torda, T. and Kopin, I.J.: Lack of preventive effect of 6-hydroxy-dopamine on a decrease of beta-adrenergic receptors induced by repeated stress in the heart of rats. Endocrinol Exp (Bratisl) 19(1): 47-51, 1985.

493. Bayorh, M.A. and Kopin, I.J.: Effect of phencyclidine (PCP) on adrenergic responses to spinal cord stimulation in pithed rats. Eur J Pharmacol 85: 15-21, 1985.

494. Burns, R.S., LeWitt, P.A., Ebert, M.H., Pakkenberg, H. and Kopin, I.J.: The clinical syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP). N Engl J Med 312(22): 1418-1421, 1985.

495. Goldstein, D.S., Zimlichman, R., Stull, R., Folio, J., Levinson, P.D., Keiser, H.R. and Kopin, I.J.: Measurement of regional neuronal removal of norepinephrine in man. J Clin Invest 76: 15-21, 1985.

49

496. Zukowska-Grojec, Z., Bayorh, M.A., Kopin, I.J. and Feuerstein, G.: Overall and regional hemodynamic effects of leukotriene D4 in spontaneously hypertensive rats. Hypertension 7(4): 507-513, 1985.

497. Polinsky, R.J., Goldstein, D.S., Brown, R.T., Keiser, H.R. and Kopin, I.J.: Decreased sympathetic neuronal uptake in idiopathic orthostatic hypotension. Annals of Neurology: 18(1): 48-53, 1985.

498. Lozovsky, D., Kopin, I.J. and Saller, C.F.: Modulation of dopamine receptor supersensitivity by chronic insulin: implication in schizophrenia. Brain Res 343(1): 190-193, 1985.

499. Haass, M., Kopin, I.J., Goldstein, D.S. and Zukowska-Grojec, Z.: Differential inhibition of alpha adrenoceptor-mediated pressor responses by rat atrial natriuretic peptide in the pithed rat. J Pharmacol Exp Ther 235(1): 122-127, 1985.

500. Weise, V.K., Palkovits, M. and Kopin, I.J.: Effect of ventral noradrenergic bundle transection and locus coeruleus lesions on urinary 3-methoxy-4-hydroxyphenylethylenglycol (MHPG) excretion in the rat. Brain Res 359(1-2): 239-245, 1985.

501. Kopin, I.J.: Catecholamine metabolism: Basic aspects and clinical significance. Pharmacol Rev 37: 333-364, 1985.

502. Corsini, G.U., Pintus, S., Chiueh, C.C., Weiss J.F. and Kopin, I.J.: 1-Methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocaramate. Eur J Pharmacol 119(1-2): 127-128 1985.

503. Bayorh, M.A., Zukowska-Grojec, Z., Ezra, D., Kopin, I.J. and Feuerstein, G: Leukotriene D4 reduces pressor responses to sympathetic stimulation, angiotensin, and vasopressin. Adv Prostaglandin Thromboxamane Leukotriene Res 13:51-54, 1985.

1986

504. Fournier, R.D., Chiueh, C.C., Kopin, I.J., Knapka, J.J., DiPette, D. and Preuss, H.G.: Refined carbohydrate increases blood pressure and catecholamine excretion in SHR and WKY. Am J Physiol 250: E381-E385, 1986.

505. Goldstein, D.S., Zimlichman, R., Stull, R., Keiser, H.R. and Kopin, I.J.: Estimation of intrasynaptic norepinephrine concentrations in humans. Hypertension 8(6): 471-475, 1986.

506. Finberg, J.P.M. and Kopin, I.J.: Chronic clorgyline treatment enhances release of norepinephrine following sympathetic stimulation in the rat. Naunyn-Schmiedeberg’s Arch Pharmacol 332: 236-242, 1986.

507. Bankiewicz, K.S., Oldfield, E.H., Chiueh, C.C., Doppman, J.L., Jacobowitz, D.M. and Kopin, I.J.: Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci 39: 7-16, 1986.

50

508. Joyce, J.N., Marshall, J.F., Bankiewicz, K.S., Kopin, I.J. and Jacobowitz, D.M.: Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) is asso-ciated with regional ipsilateral changes in striatal dopamine D2 receptor density. Brain Res 382(2): 360-364, 1986.

509. Preuss, H.G., Fournier, R.D., Chiueh, C.C., Kopin, I.J., Knapka, J.J., DiPette, D., More, N.W. and Rao, N.A.: Refined carbohydrates affect blood pressure and retinal vasculature in spontaneously hypertensive and Wistar Kyoto rats. J. Hypertens [Suppl] 4: S459-S462, 1986.

51

510. Kopin, I.J., Burns, S.R., Chiueh, C.C. and Markey, S.: MPTP-induced parkinsonian syndromes in humans and animals. In: Fisher, A., Hanin I. and Lachman, C. (Eds.) Alzheimer’s and Parkinson’s Diseases New York, Plenum Publishing Corporation, 519-530, 1986.

511. Zukowska-Grojec, Z., Haass, M., Kopin, I.J. and Zamir, N.: Interactions of artial natriuretic peptide with the sympathetic and endocrine systems in the pithed rat. J Pharmacol Exp Ther 239(2): 480-487, 1986.

512. Eisenhofer, G., Goldstein, D.S., Stull R., Keiser, H.R., Sunderland T., Murphy, D.L. and Kopin, I.J.: Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxypheyl-alanine in plasma, and their responses to inhibition of monoamine oxidase. Clin Chem 32(11): 2030-2033, 1986.

513. Siever, L.J., Uhde, T.W., Jimerson, D.C., Lake, C.R., Kopin, I.J. and Murphy D.L.: Indices of noreadrenergic output in depression. Psychiatry Res 19(1): 59-73, 1986.

514. Kopin, I.J.: Toxins and Parkinson’s Disease: MPTP Parkinsonism in Humans and Animals. In: Yahr, M.D., Bergmann, K.J. (Eds.) Advances in Neurology, New York, Raven Press, 137-144, 1986.

515. Chiueh, C.C., Firnau, G., Burns, R.S., Nahmias, C., Chirakal, R., Kopin, I.J. and Garnett, E.S.: Determination and visualization of damage to striatal dopaminergic terminals in 1-Methyl- 4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism by [18F]-labeled 6-fluoro-L-dopa and positron emission tomography. Adv. Neurol. 45:167-169, 1986.

516. Chiueh, C.C., Burns, R.S., Kopin, I.J. and Kirk, K.L.;6-18F-DOPA/Position emission tomography visualized degree of damage to brain dopamine in basal ganglia of monkeys with MPTP-induced parkinsonism. In: Markey, S.P., Castagnoli, N., Jr., Trevor, A.J. and Kopin, I.J. (Eds.) MPTP: A Neurotoxin Producing a Parkinsonian Syndrome, Orlando, Florida, Academic Press, 327-338, 1986. 1987

517. Corsini, G.U., Zuddas, A., Bonuccelli, U. Schnelli, S. and Kopin, I.J.: 1-Methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhan-ced by ethanol or acetaldehyde. Life Sci. 40: 827-832, 1987.

518. Polinsky, R.J., Brown, R.T., Lee, G.K., Timmers, K., Culman, J., Foldes, O., Kopin, I.J. and Recant, L.: Endorphin, ACTH, and catecholamine responses in chronic autonomic failure. Ann. Neur. 22:573-577, 1987.

519. Kopin, I.J.: Toxins and Parkinson’s disease: MPTP parkinsonism in humans and animals. Adv. Neurol. 45:137-144, 1987.

520. Pohl, R., Ettedgui, E., Bridges, M., Lycaki, H., Jimerson, D., Kopin, I., and Rainey, J.M.: Plasma MHPG levels in lactate and isoproterenol anxiety states. Biol. Psychiatry 22:1127-1136, 1987.

52

521. Porrino, L.J., Burns, R.S., Crane, A.M., Palombo, E., Kopin, I.J., and Sokoloff, L.: Changes in local cerebral glucose utilization associated with Parkinson’s syndrome indiced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the primate. Life Sci. 40:1657-1664, 1987.

522. Kopin, I.J.: MPTP-induced neurotoxicity. In: Peter Jenner, (Ed): Neurotoxins and Their Pharmacological Implications, New York, Raven Press, 163-178, 1987.

523. Chiueh, C.C., Firnau, G., Burns, R.S., Nahmias, C., Chirakal, R., Kopin, I.J., and Garnett, E.S.: Determination and visualization of damage of striatal dopaminergic terminals in 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine-induced parkin-sonism by [18F]-labelled 6-fluoro-L-dopa and positron emission tomo-graphy. Adv. Neurol. 45:167-169, 1987.

524. Goldstein, D.S., Udelsman, R., Eisenhofer, G., Stull, R., Keiser, H.R., and Kopin, I.J.: Neuronal source of plasma dihydroxyphenylalanine. J. Clin. Endocrinol. Metab. 64:856-861, 1987.

525. Eisenhofer, G., Ropchak, T.G., Stull, R.W., Goldstein, D.S., Keiser, H.R., and Kopin, I.J.: Dihydroxyphenylglycol and intraneuronal metabolism of endogenous and exogenous norepinephrine in the rat vas deferens. J. Pharmacol. Exp. Ther. 241:547-553, 1987.

526. Goldstein, D.S., Eisenhofer, G., Sax, F.L., Keiser, H.R., and Kopin, I.J.: Plasma norepinephrine pharmacokinetics during mental challenge, Psychosomatic Medicine: 49:591- 605, 1987.

527. Eisenhofer, G., Goldstein, D.S., Stull, R.W., Gold, P.W., Keiser, H.R., and Kopin, I.J.: Short Communication. Dissociation between corticotrophin and catecholamine responses to isoprenaline in humans, Clin. and Exp. Pharmacol. & Physiol. 14:337-341, 1987.

528. Brown, R.T., Polinsky, R.J., and Kopin, I.J.: Interconversion of O-methylated norepinephrine metabolites in humans. J. Lab. Clin. Med. 110:119-124, 1987.

529. Haass, M., Zukowska-Grojec, Z, Kopin, I.J., and Zamir, N.: Role of autonomic nervous system and vasoactive hormones in the release of atrial natriuretic peptides in conscious rats. J. Cardiovasc. Pharmacol. 10:424-432, 1987.

530. Barone, P., Bankiewicz, K.S., Corsini, G.U., Kopin, I.J., and Chase, T.N.: Dopaminergic mechanisms in hemiparkinsonian monkeys. Neurology 37:1592-1595, 1987.

531. Finberg, J.P., and Kopin, I.J.: Chronic clonidine treatment produces desensitisation of post- but not presynaptic alpha 2-adrenoceptors. Eur. J. Pharmacol. 138:95-100, 1987.

532. Porrino, L.J., Burns, R.S., Carne, A.M., Palombo, E., Kopin, I.J., Sokoloff, L.: Local cerebral metabolic effects of L-dopa therapy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- induced parkinsonism in monkeys. Proc. Natl. Acad. Sci. 84:5995-5999, 1987.

533. Eisenhofer, G., Goldstein, D.S., Stull, R., Ropchak, T.G., Keiser, H.R., Kopin, I.J.: Dihydroxyphenylglycol and dihydroxymandelic acid during intravenous infusions of noradrenaline. Clin. Sci. 73:123-127, 1987. 53

534. Kopin, I.J.: MPTP: An industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson’s Disease. Environ.Health Perspect. 75:45-51, 1987.

534a. Schuette, W.H., Bankiewicz, K.S., Markowitz, A., Plowman, F.A., Kopin, I.J.: A system for measuring the angular response of hemiparkinsonian monkeys to a food stimulus. Med. Instrum. 21: 314-316, 1987.

1988

535. Kopin, I.J. and Schoenberg, D.G.: MPTP in animal models of Parkinson’s disease: Mt. Sinai J. Med. 55:43-49, 1988.

536. Kopin, I.J. and Markey, S.P.: MPTP Toxicity: Implications for research in Parkinson’s disease. Am. Rev. Neurosci. 11:81-96.

54

537. Kopin, I.J.: New opportunities for Parkinson’s disease research: The MPTP-induced parkinsonian syndrome in humans and animals. In: Jack D. Barchas, William E. Bunney, Jr., (Eds.), Perspectives in Psychopharmacology; A Collection of Papers in Honor of Earl Usdin. Neurology and Neurobiology, Vol. 40. New York, Alan R. Liss, Inc., 249-262, 1988.

538. Polinsky, R.J., Taylor, I.L., Weise, V., Kopin, I.J.: Gastrin responses in patients with adrenergic insufficiency. J. Neurol. Neurosurg. Psychiatry. 51:67-71, 1988.

539. Kopin, I.J., Bankiewicz, K., Harvey-White, J: Assessment of brain dopamine metabolism from plasma HVA and MHPG during debrisoquin treatment: Validation in monkeys treated with MPTP. Neuropsychopharmacology 1(2):119-125, 1988.

540. Brücke, T., Bankiewicz, K., Harvey-White, J., Kopin, I.J.: The partial dopamine receptor agonist terguride in the MPTP-induced hemiparkinsonian monkey model. Eur. J. Pharmacol. 148:445-448, 1988.

541. Eisenhofer, G., Ropchak, T.G., Kopin. I.J., Goldstein, D.S.: Release, metabolism, and intraneuronal disposition of newly synthesized norepinephrine in rat vas deferens. J. Pharmacol. Exp. Ther. 245:81-88, 1988.

542. Goldstein, D.S., Eisenhofer, G., Stull, R., Folio, C.J., Keiser, H.R., Kopin, I.J.: Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J. Clin. Invest. 81:213-220, 1988.

543. Schinelli, S., Zuddas, A., Kopin, I.J., Barker, J.L., di Porzio, U.: 1-Methyl-4-phenyl- 1,2,3,6-tetrahydropyridine metabolism and 1-methyl-4-phenylpyridinium uptake in dissociated cell cultures from the embryonic mesencephalon. J. Neurochem. 50:1900-1907, 1988.

544. Kopin, I.J., Oliver J.A., Polinsky, R.J.: Relationship between urinary excretion of homovanillic acid and norepinephrine metabolites in normal subjects and patients with orthostatic hypotension. Life Sci. 43:125-131, 1988.

545. Kopin, I.J., Bankiewicz, K., Harvey-White, J.: Effect of MPTP-induced parkinsonism in monkeys on the urinary excretion of HVA and MHPG during debrisoquin administration. Life Sci. 43:133-141, 1988.

546. Szemeredi, K., Zukowska-Grojec, Z., Bagdy, G., Hill, J., Kopin, I.J.: Evidence for a direct peripheral effect of clonidine on the norepinephrine release in vivo in pithed rats. Eur. J. Pharmacol. 145(3):251-255, 1988.

547. Ho, V.W., Porrino, L.J., Crane, A.M., Burns, R.S., Kopin, I.J., Sokoloff, L.: Metabolic mapping of the oculomotor system in MPTP-induced parkinsonian monkeys. Ann. Neurol. 23:86-89, 1988.

548. Kopin, I.J., Harvey-White, J, Bankiewicz, K.: A new approach to biochemical evaluation of brain dopamine metabolism. Cell Mol. Neurobiol. 8(2):171-179, 1988.

55

549. Polinsky, R.J., Brown, R.T., Burns, R.S., Harvey-White, J., Kopin, I.J.: Low lumbar CSF levels of homovanillic acid and 5-hydroxyindoleacetic acid in multiple system atrophy with autonomic failure. J. Neurol. Neurosurg. Psychiatry. 51:914-919, 1988.

550. Szemeredi, K., Bagdy, G., Stull, R., Keiser, H.R., Kopin, I.J., Goldstein, D.S.: Sympathoadrenomedullary hyper-responsiveness to yohimbine in juvenile spontaneoulsy hypertensive rats. Life Sci. 43:1063-1068, 1988.

551. Duncan, M.W., Kopin, I.J., Garruto, R.M., Lavine L., Markey, S.P.: 2-Amino- 3(methylamino)-propionic acid in cycad-derived foods is an unlikely cuase of amyotrophic lateral sclerosis/parkinsonism. Lancet, September 10, 1988, p 631, 1988.

552. Eisenhofer, G., Goldstein, D.S., Ropchak, T.G., Nguyen, H.Q., Keiser, H.R., Kopin, I.J.: Source and physiological significance of plasma 3,4-dihydroxyphenylglycol and 3-methoxy-4- hydroxyphenylglycol. J. Auton. nerv. Syst., 24:1-14, 1988.

553. Szemeredi, K., Bagdy, G., Stull, R., Calogero, A.E., Kopin, I.J., Goldstein, D.S.: Sympathoadrenomedullary inhibition by chronic glucocorticoid treat-ment in conscious rats. Endocrinology 123:2585-2590, 1988.

554. Hovevey-Sion, D., Harvey-White, Kopin, I.J.: Measurement of homovanillic acid in small volumes of plasma using liquid chromatography with electrochemical detection. J. Chromatog. 426:141-147.

555. Palombo, E., Porrino, L.J., Bankiewicz, K.S., Crane, A.M., Kopin, I.J., Sokoloff, L.: Administration of MPTP acutely increases glucose utilization in the substantia nigra of primates. Brain Res. 453:227-234, 1988.

556. Eisenhofer, G., Kirk, K.L., Kopin, I.J., Goldstein, D.S.: Simultaneous determination of endogenous catechols and exogenous 2- and 6-fluorinated catechols in tissue and plasma using liquid chromatography with electrochemical detection. J. Chromatog. 431:156-162, 1988.

557. Eisenhofer, G., Ropchak, T., Nguyen H., Keiser, H.R., Kopin, I.J., Goldstein, D.S.: Source and physiological significance of plasma 3,4-dihydroxyphenylalanine in the rat. J. Neurochem. 51:1204-1213, 1988.

558. Goldstein, D.S., Kopin, I.J.: Plasma norepinephrine as an index of sympathetic neuronal function in health and disease. In Saito E. (Ed.), Progress in Hypertension. (Vol. I). Neurotransmitters as Modulators of Blood Pressure. Utrecht, Holland; VNU Science Press, 1988, pp. 65-87.

559. Bankiewicz, K.S., Plunkett, R.J., Kopin, I.J., Jacobowitz, D.M., London, W.T., Oldfield, E.H.: Transient behavioral recovery in hemiparkinsonian primates after adrenal medullary allografts. Progress in Brain Research 78:543-549. In: D.M. Gash and J.R. Sladek, Jr., (Eds.) Transplantation into the Mamalian CNA: Preclinical and Postclinical Studies. Elsevier, Amsterdam, 1988.

560. Kopin, I.J.: MPTP effects on dopamine neurons. In: The Mesocorticolimbic Dopamine System. Vol. 537, Annals of the New York Academy of Sciences, 1988.

56

561. Kopin, I.J., Eisenhofer, G., Goldstein, D.S.: Adrenergic response following recognition of stress. in G.P. Chrousos, D. L. Loriaux, P.W. Gold (Eds.), Mechanisms of Physical and Emotional Stress. Plenum Press, New York, 1988.

562. Kopin, I.J., Bankiewicz, K.S., Plunkett, R.J., Porrino, L., Jacobowitz, D.M., London, W.T., Oldfield, E.H.: Recent Advances in dopaminergic implants. In Hefti, F., and Weiner, W.J. (Eds.), Progress in Parkinson Research. Plenum Publishing Corporation, 1988, pp. 205-210.

563. Kopin, I.J., Bankiewicz, K.S., Palombo, E., Porrino, L.: Nonmotor aspects of chronic 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in primates. In Sandler, M., Dahlstrom, A., Belmaker, R.H. (Eds.), Progress i Catecholamine Research, Part B: Central Aspects. Alan R. Liss, New York, NY, 1988, pp. 109-112.

57

1989

564. Kopin, I.J., Eisenhofer, G., Goldstein, D.: Adrenergic response following recognition of stress. In S. Breznitz and O Zinder (Eds.), Molecular Biology of Stress. Alan R. Liss, Inc., New York, 1989, pp. 123-132.

565. Kopin, I.J.: Plasma levels of catecholamines and dopamine---hydroxylase. In: U. Trendelenburg and N. Weiner (Eds.) Handbook of Experimental Pharmacology, Vol. 90/III. Springer-Verlag, Heidelberg, Germany, 1989.

566. Szemeredi, K., Zukowska-Grojec, Z., Bagdy, G., Feketes, M.I., Kopin, I.J.: Opposite effects of chronic cortisol treatment on pre- and postsynaptic actions of clonidine in pithed rats. J. Auton. Pharmac. 9:35-43, 1989.

567. Eisenhofer, E., Hovevey-Sion, D., Kopin, I.J., Miletich, R., Kirk, K.L., Finn, R., Goldstein, D.S.: Neuronal uptake and metabolism of 2- and 6-fluorodopamine: False neurotransmitters for positron emission tomographic imaging of sympathetically innervated tissues. J. Pharmacol. Exp. Ther. 248:419-427, 1989.

568. Eisenhofer, E., Brush, J.E., Cannon, R.O., Stull, R., Kopin, I.J., Goldstein, D.S.: Plasma dihydroxyphenylalanine and total body and regional noradrenergic activity in humans. J. Clin. Endocrin. Metab., 68:247-255, 1989.

569. Eisenhofer, E., Goldstein, D.S., Kopin, I.J.: Plasma dihydroxyphenylglycol for estimation of noradrenaline neuronal re-uptake in the sympathetic nervous system in vivo. Clinical Sci., 76:171-182, 1989.

570. Duncan, M.W., Kopin, I.J., Crowley, J.S., Jones, S.M., Markey, S.P.: Quantification of the putative neurotoxin 2-amino-3-(methylamino) propanoic acid (BMAA) in cycadales: Analysis of the seeds of some members of the family Cycadaceae. J. Anal. Toxicol., 13:169- 175, 1989.

57l. Deka-Starosta, A., Garty, M., Zukowska-Grojec, Z., Keiser, H.R., Kopin, I.J., Goldstein, D.S.: Renal sympathetic nerve activity and norepinephrine release in rats. Am. J. Physiol. 257:R229-R236, 1989.

572. Johannessen, JN, Chiueh, CC, Bacon, JP, Garrick, NA, Burns, RS, Weise, VK, Kopin, IJ, Parisi, JE, Markey, SP. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the Dog: Effect of Pargyline Pretreatment. J Neurochem 1989 582-589.

573. Zuddas, A., Corsini, G.U., Schinelli, S., Barker, J.L., Kopin, I.J., diPorsio, U.: Acetaldehyde directly enhances MPP+ neurotoxicity and delays its elimination from the striatum. Brain Res, 501:11-22, 1989.

574. Zuddas, A., Corsini, G.U., Schinelli, S., Johannessen, J.N., diPorzio, U., Kopin, I.J.; MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra. Brain Res, 501:1-10, 1989.

58

575. Goldstein, D.S., Polinsky, R.J, Garty, M., Robertson, D., Brown, R.T., Biaggioni, I., Stull, R., Kopin, I.J.: Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. Ann. Neurol. 26:558-563, 1989.

576. Goldstein, D.S., Eisenhofer, G., Garty, M, Sax, F.L., Keiser, H.R., Kopin, I.J.: Pharmacologic and tracer methods to study sympathetic function in primary hypertension. Clin. Exp. Hypertens. 11:173-189, 1989.

577. Garty, M., Deka-Starosta, A., Stull, R., Kopin, I.J., Goldstein, D.S. Plasma levels of catechols after fasting in intact or adrenal-demedullated rats. J. Auton. Nerv. Syst., 26:181-184.

578. Goldstein, D.S., Eisenhofer, G., Garty, M., Folio, C.J., Stull, R., Brush, J.E., Sax, F.L., Keiser, H.R., Kopin, I.J. Implications of plasma levels of catechols in the evaluation of sympathoadrenomedullary function. Am. J. Hypertens., 2:133S-139S, 1989.

579. Garty, M., Stull, R., Kopin, I.J., Goldstein, D.S., Skin color, aging, and plasma L-dopa levels. J. Auton. Nerv. Syst., 26:261-263, 1989.

580. Garty, M., Deka-Starosta, A., Chang, P.C., Eisenhofer, G., Zukowska-Grojec, Z., Stull, R., Kopin, I.J., Goldstein, D.S. Plasma levels of catechols during reflexive changes in sympathetic nerve activity. Neurochem. Res., 14:523-531, 1989.

581. Hovevey-Sion, D., Kopin, I.J., Stull, R.W., Goldstein, D.S., Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma. Neuropharmacology 28:791-797, 1989.

582. Szemeredi, K., Stull, R., Kopin, I.J., Goldstein, Effects of a peripherally acting -2- adrenoceptor antagonist (L-659, 066) on hemodynamics and plasma levels of catechols in conscious rats. E. J. Pharmacol. 170:53-59, 1989.

583. Marini, A.M., Schwartz, J.P., Kopin, I.J., The neurotoxicity of 1-methyl-4- phenylpyridinium in cultured cerebellar granule cells, J. Neurosci., 9:3665-3672, 1989.

584. Kopin, I.J. Reflections of the role of Adrenergic mechanisms in ventricular arrhythmias, In: J. Brachmann, A. Schomig (Eds.) Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction, Springer-Verlag, New York, pp. 123-1133, 1989.

585. Goldstein, D.S., Kopin, I.J., The autonomic nervous system and catecholamines in normal blood pressure control and in hypertension, in: J.H.Laragh, B.M. Brenner, (Eds.), Hypertension: Pathophysiology, Diagnosis, and Management. Raven Press, New York, p. 711, 1989.

586. Szemeredi, K., Bagdy, G., Kopin, I.J., Goldstein, D.S., Neurocirculatory regulation in cortisol-induced hypertension, Clin. Exper. Hyper., A11:1425-1439, 1989.

587. Culman, J., Chiueh, C.C., Foldes, O., Kopin, I.J.: Circulating catecholamines are not involved in immobilization stress-induced plasma ACTH rise in rats with transection of the pituitary stalk. In: G.R. Van Loon, R. Kvetnansky, R. McCarty and J. Axelrod. (Eds.) Stress:

59

Neurochemical and Humoral Mechanisms. Gordon and Breach Science Publishers, S.A., New York, 425-436, 1989.

1990

588. Bankiewicz, K.S., Plunkett, R.J., Jacobowitz, D.M., Porrino, L., di Porzio, U., London, W.T., Kopin, I.J., and Oldfield, E.H., The effect of fetal mesencephalon implants on primate MPTP-induced parkinsonism: Histochemical and behavioral studies, J. Neurosurg., 231-144, 1990.

589. Kopin, I.J.: False Adrenergic transmitters and positron emission tomographic imaging of myocardial sympathetic innervation. Circulation, 82:646-648, 1990.

590. Szemeredi, K., Komoly, S., Kopin, I.J., Bagdy, G., Keiser, H.R., Goldstein, D.S.: Simultaneous measurement of plasma and brain extracellular fluid concentrations of catechols after yohimbine administration in rats. Brain Research, 542:8-14, 1990.

591. Kopin, I.J.: In-vivo quantitative imaging of catecholaminergic nerve terminals in brain and peripheral organs using positron emission tomography (PET). J. Neural Transm. 32:19-27, 1990.

592. Garty, M., Deka-Starosta, Chang, P., Kopin, I.J., Goldstein, D.S.: Effects of clonidine on renal sympathetic nerve activity and norepinephrine spillover, J. Pharmacol. Exp. Therap. 254:1068-1075, 1990.

593. Bankiewicz, K.S., Plunkett, R.I., Mefford, I., Kopin, I.J., Oldfield, E.H., Behavioral recovery from MPTP-induced parkinsonism in monkeys after intracerebral tissue implants is not related to CSF concentrations of dopamine metabolites. Prog. Brain Res. 82:561-5671, 1990.

594. Garty, M., Deka-starosta, A., Stull, R., Kopin, I.J., Goldstein, D.S., Effects of general anesthetics on plasma levels of catechols in intact and in adrenal-demedulated rats. Biogenic Amines, 5:435-443, 1990.

595. Szemeredi, K., Bagdy, G., Stull, R., Kopin, I.J., Goldstein, D.S., Cortisol and alpha-2 adrenergic regulation of sympathoneural activity, Biogenic Amines, 5:445-454, 1990.

596. Hovevey-Sion, D., Eisenhofer, G., Kopin, I.J., Kirk, K.I., Szemeredi, K., Goldstein, D.S. Metabolic fate of injected radiolabelled dopamine and 2-fluorodopamine in rats, Neuropharmacol. 29:881-887, 1990.

597. Goldstein, D., Chang, P.C., Eisenhofer, G., Miletich, R., Finn, R., Bacher, J., Kirk, K.L., Bacharach, S., Kopin, I.J. Positron emission tomographic imaging of cardiac sympathetic innervation and function. Circulation 81(5):1606-1621, 1990.

598. Duncan, M.W., Steele, J.C., Kopin, I.J., Markey, S.P. 2-Amino-3-(methylamino)- propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Neurology 40:767-772, 1990.

60

599. Chang, P.C., Szemeredi, K., Grossman, E., Kopin, I.J., Goldstein, D.S. Fate of tritiated 6- fluorodopamine in rats: a false neurotransmitter for positron emission tomographic imaging of sympathetic innervation and function. J. Pharmacol. Exp. Ther. 255:809-817, 1990.

600. Palombo, E., Porrino, L.J., Bankiewicz, K.S., Crane, A.M., Sokoloff, L., Kopin, I.J. Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP. J. Neurosci. 10:860-869, 1990.

1991

601. Bankiewicz, K.S., Plunkett, R.J., Jacobowitz, D.M., Kopin, I.J., Oldfield, E.H. Fetal nondopaminergic neural implants in parkinsonian primates. J. Neurosurgery 74:97-104, 1991.

602. Goldstein, D.S., Chang, P.C., Smith, B., Herscovitch, P., Austin, S.M., Eisenhofer, Kopin, I.J. Dosimetric estimates for clinical positron emission tomographic scanning after injection of [18F]-6-fluorodopamine. J. Nuclear Med. 32:102-110, 1991.

603. Bankiewicz, K.S., Oldfield, E.H., Plunkett, R.J., Schuette, W.H., Cogan, D.G., Hogan, N., Zuddas, A., Kopin, I.J. Apparent unilateral visual neglect in MPTP-hemiparkinsonian monkeys is due to delayed initiation of motion. Brain Res. 541:98-102, 1991.

604. Goldstein, D.S., Grossman, E., Tamrat, M., Chang, P.C., Eisenhofer, G., Bacher, J., Kirk, K.L., Bacharach, S., Kopin, I.J. Positron emission imaging of cardiac sympathetic innervation and function using 18F-6-fluorodopamine: Effects of chemical sympathectomy by 6- hydroxydopamine. J. Hypertens. 9:417-423, 1991.

605. Zudas, A., Corsini, G.U., Barker, J.L., Kopin, I.J., di Porzio, U. Specific reinnervation of lesioned mouse striatum by grafted mesencephalic dopaminergic neurons. Eur. J. Neurosci. 3:72- 85, 1991.

606. Grossman, E., Chang, P.C., Hoffman, A., Tamrat, M., Kopin, I.J., Goldstein, D.S. Tracer norepinephrine kinetics: dependence on regional blood flow and the site of infusion. Am. J. Physiol. 260:R946-R952, 1991.

607. Szemeredi, K., Pacak, K., Kopin, I.J., Goldstein, D.S., Sympathoneural and skeletal muscle contributions to plasma DOPA responses in pithed rats. J. Autonom. Nerv. Sys. 35:169- 174, 1991.

608. Duncan M.W., Villacresses N.E., Pearson P.G., Waytt L., Rapoport S.I., Kopin I.J., Markey S.P., Smith O.R. 2-Amino-3-(methylamino)-propanoic acid (BMAA) pharmacokinetics and blood-brain barrier permeability in the rat. J Pharmacol Exp Ther, 258:27-35, 1991.

609. Palombo E., Porrino L.J., Crane A.M., Bankiewicz K.S., Kopin I.J., Sokoloff L. Cerebral metabolic effects of monoamine oxidase inhibition in normal and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine acutely treated monkeys. J Neurochem, 56(5):1639-1646, 1991.

610. Szemeredi K., Komoly S., Kopin I.J., Bagdy G., Keiser H.R., Goldstein D.S. Simultaneous measurement of plasma and brain extracellular fluid concentrations of catechols after yohimbine administration in rats. Brain Research, 542:8-14, 1991. 61

611. Eisenhofer G., Esler M.D., Goldstein D.S., Kopin I.J. Neuronal uptake, metabolism, and release of tritium-labeled norepinephrine during assessment of its plasma kinetics. Am J Physiol, 269:E505-E515, 1991.

612. Culman, J., Kopin, I.J., Saavedra, J.M. Regulation of corticotropin-releasing hormone in pituitary-adrenocortical response during acute and repeated stress in the rat. Endocrine Regulations, 25:151-158, 1991.

612a Zuddas A, Corsini GU, Barker JL, Kopin IJ, Di Porzio U. Specific Reinnervation of Lesioned Mouse Striatum by Grafted Mesencephalic Dopaminergic Neurons. Eur J Neurosci. 3:72-85,1991 1992

613. Duncan M.W., Markey S.P., Weick B.G., Pearson P.G., Ziffer H., Hu Y., Kopin I.J. 2- Amino-3-(methylamino)propanoic acid (BMAA) bioavailability in the primate. Neurobiol Aging, 13:333-337, 1992.

614. Pacak K., Armando I., Komoly S., Fukuhara K., Weise V.K., Holmes C., Kopin I.J., Goldstein D.S. Hypercortisolemia inhibits yohimbine-induced release of norepinephrine in the posterolateral hypothalamus of conscious rats. Endocrinology, 131:1369-1376, 1992.

615. Kvetnansky R., Goldstein D.S., Weise V.K., Holmes C., Szemeredi K., Bagdy G., Kopin I.J. Effects of handling or immobilization on plasma levels of dopa, catecholamines, and metabolites in rats. J Neurochem 58:2296-2302, 1992.

616. McMahon A., Kvetnansky R., Fukuhara K., Weise V.K., Kopin I.J., Sabban E.L. Regulation of tyrosine hydroxylase and dopamineß-ß-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress. J Neurochem, 58:2124-2130, 1992.

617. Kopin I.J. Origins and significance of dopa and catecholamine metabolites in body fluids. Pharmacopsychiat, 24:33-36, 1992.

618. Marini A.M., Lipsky R.H., Schwartz J.P., Kopin I.J. Accumulation of 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine in cultured cerebellar astro-cytes. J Neurochem, 58:1250-1258, 1992.

619. Pacak K., Armando I., Fukuhara K., Kvetnansky R., Kopin I.J., Goldstein D. Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization stress in rats. Brain Research, 589:91-96, 1992.

620. Kopin I.J. Mechanisms of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced destruction of dopaminergic neurons: in Selective Neurotoxicity H. Herken, F. Hucho, Eds., Springer-Verlag, Heidelberg Germany, 1992, pp. 333-356.

621. Kopin I.J. Features of the Dopaminergic Neurotoxin MPTP: in: Neurotoxins and Neurodegenerative Disease, J.W. Langston, Anne Young, eds. Ann NY Acad Sci, 648:96-104, 1992.

62

622. Grossman E., Hoffman A., Armando I., Abassi Z., Kopin I.J., Goldstein D.S. Sympathoadrenal contribution to plasma dopa (3,4-dihydroxyphenylalanine) in rats. Clin Sci, 83:65,74, 1992.

1993

623. Kopin I.J., Bankiewicz K.S., Plunkett R.F., Jacobowitz D.M., Oldfield E.H. Tissue implants in treatment of parkinsonian syndromes in animals and implications for use of tissue implants in humans. Advances in Neurology, 60:707-714, 1993.

624. Lenders J.W., Eisenhofer G., Aramando I., Keiser H. R., Goldstein D.S., Kopin I.J. Determination of in plasma by liquid chromotography with electrochemical detection. Clin Chem, Jan;39(1):97-103, 1993.

625. Kopin I.J. The pharmacology of Parkinson’s disease therapy: an update. Annu Rev Pharmacol Toxicol 33:467-497, 1993.

626. Wolfovitz E., Grossman E., Folio C.J., Keiser H.R., Kopin I.J., Goldstein D.S. Derivation of urinary dopamine from plasma dihydroxyphenylalanine in humans. Clin Sci, May;84(5):549-557, 1993.

627. Finberg J.P., Pacak K., Kopin I.J., Goldstein D.S. Chronic inhibition of monoamine oxidase type A increases noradrenaline release in rat frontal cortex. Naunyn Schmiedergs Arch Pharmacol, May;347(5):500-505, 1993.

628. Lenders J.W., Kvetnansky R., Pacak K., Goldstein D.S., Kopin I.J., Eisenhofer G. Extraneuronal metabolism of endogenous and exogenous norepinehprine and epinehprine in rats. J Pharmacol Exp Ther, Jul;266(1):288-293, 1993.

629. Nankova B., Devlin D., Kvetnansky R., Kopin I.J., Sabban E.L. Repeated immobilization stress increases the binding of c-Fos-like proteins to a rat dopamine beta- hydroxylase promoter enhancer sequence. J Neurochem Aug;61(2):776-779, 1993.

630. Kopin I.J. Clinical Evaluation of Tyrosine Hydroxylase Activity in Brain and Peripheral Organs. Tyrosine Hydroxylase Activity in Brain and Peripheral Organs. In: Naoi M, ed. Tyrosine Hydroxylase, 1993, 195-216.

631. Miletich RS, Comi G, Bankiewicz K, Plunkett R, Adams R, Di Chiro G, Kopin IJ. 6- [18F]Fluoro-L-dihydroxyphenylalanine Metabolism and Positron Emission Tomography after Catechol-O-methyltransferase Inhibition in Normal and Hemiparkinsonian Monkeys. Brain Research, 626:1-13, 1993.

632. Goldstein DS, Eisenhofer G, Dunn BB, Armando I, Lenders J, Grossman E, Holmes C, Kirk KL, Bacharach S, Adams R, Herscovitch P, Kopin IJ. Positron emission tomographic imaging of cardiac sympathetic innervation using 6-[18F]fluorodopamine: initial findings in humans. J Am Coll Cardiol 22:1961-71, 1993.

63

633. Goldstein DS, Garty M, Bagdy G, Szemeredi K, Sternberg EM, Listwak S, Deka- Starosta A, Hoffman A, Chang PC, Stull R, Gold PW, Kopin IJ. Role of CRH in glucopenia- induced adrenomedullary activation in rats. J Neuroendocrinology 5:475-86, 1993.

634. Kvetnansky R, Fukuhara K, Pacak K, Cizza G, Goldstein DS, Kopin IJ. Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats. Endocrinology 133:1411-9, 1993.

635. Pacak K, Kvetnansky R, Palkovits M, Fukuhara K, Yadid G, Kopin IJ, Goldstein DS. Adrenalectomy augments in vivo release of norepinephrine in the paraventricular nucleus during immobilization stress. Endocrinology 133:1404-10, 1993.

636. Pacak K, Yadid G. Jakab G, Lenders JW, Kopin IJ, Goldstein DS. In vivo hypothalamic release and synthesis of catecholamines in spontaneously hypertensive rats. Hypertension 22:467-78, 1993.

637. Pacak K, Palkovits M, Kvetnansky R, Fukuhara K, Armando I, Kopin IJ, Goldstein DS. Effects of single or repeated immobilization on release of norepinephrine and its metabolites in the central nucleus of the amygdala in conscious rats. Neuroendocrinology 57:626-33, 1993.

638. Pacak K, Palkovits M, Kvetnansky R, Kopin IJ, Goldstein DS. Effects of brainstem hemisections on in vivo synthesis and release of catecholamines in the paraventricular nucleus of the hypothalamus. Neuroendocrinology 58:196-201, 1993.

639. Pacak K, Yadid G, Jakab J, Lenders JW, Kopin IJ, Goldstein DS. In vivo hypothalamic release and synthesis of catecholamines in spontaneously hypertensive rats. Hypertension 22:467-78, 1993.

640. Yadid G, Pacak K, Golomb E, Harvey-White JD, Lieberman DM, Kopin IJ, Goldstein DS. Glycine stimulates striatal dopamine release in conscious rats. Br J Pharmacol 110:50-3, 1993.

641. Yadid G, Pacak K, Kopin IJ, Goldstein DS. Modified microdialysis probe for sampling extracellular fluid and administering drugs in vivo. Am J Physiol 265:R1205-11, 1993.

642. Kopin IJ. Monoamine oxidase (MAO): Relationships to foods, poisons and medicines. Biogenic Amines 9:355-65, 1993.

643. Sheng JG, McShane LM, Plunkett RJ, Cummins AC, Oldfield EH, Kopin IJ, Palmatier MA. Dopaminergic neuronal sprouting and behavioral recovery in hemi-parkinsonian rats after implantation of amnion cells. Exp Neurol, 123(2):192-203, Oct, 1993.

1994

644. Goldstein DS, Coronado L, Kopin IJ. 6-[Fluorine-18] Fluorodopamine Pharmacokinetics and Dosimety in Humans. J Nucl Med 35:964-73, 1994.

64

645. Miletich R, Bankiewicz KS, Quarantelli M, Plunkett RJ, Frank J, Kopin IJ, Di Chiro G. MRI detects acute degeneration of the nigrostriatal dopamine system after MPTP exposure in hemiparkinsonian monkeys. Ann Neurol 35:689-97, 1994.

646. Nankova B, Kvetnansky R, McMahon A, Viskupic E, Hiremagalur B, Frankle G, Fukuhara K, Kopin IJ, Sabban EL. Induction of tyrosine hydroxylase gene expression by a nonneuronal nonpituitary-mediated mechanism in immobilization stress. Proc Nat Acad Sci USA 91:5937-41, 1994.

647. Kopin IJ: Monoamine oxidase and catecholamine metabolism. J Neural Transm 41:57- 67, 1994.

648. Viskupic E, Kvetnansky R, Sabban EL, Fukuhara K, Weise VK, Kopin IJ, Schwartz JP: Increase in rat adrenal phenylethanolamine N-methyltransferase mRNA level caused by immobilization stress depends on intact pituitary-adrenocortical axis. J Neurochem 63:808-14, 1994.

649. Yadid G, Pacak K, Kopin IJ, Goldstein DS. Modified microdialysis probe for sampling extracellular fluid and administering drugs in vivo. Am J Physiol 265(5 Pt 2):R1205-11, November, 1993.

650. Kopin IJ: Tips from Toxins: the MPTP Model of Parkinson’s Disease. Neurodegnerative Diseases. Academic Press. Ltd., 1994.

651. Finberg JP, Pacak K, Goldstein DS, Kopin IJ. Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A. J Neural Transm Supply 41:123-5, 1994.

652. Yadid G, Pacak K, Kopin IJ, Goldstein DS. Endogenous serotonin stimulates striatal dopamine release in conscious rats. J pharmacol Exp Ther 270(3):1158-65, Sept, 1994.

653. Kopin IJ: Neurotransmitters and Disorders of the Basil Ganglia. Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 5th Edition, ed. GJ Siegel, Raven Press, Ltd., New York, 1994.

654. Chang PC, Grossman E, Kopin IJ, Goldstein DS. On the existence of functional beta- adrenoceptors on vascular sympathetic nerve endings in the human forearm. J Hypertens;12(6):681-90, June,1994.

655. Eisenhofer G, Pecorella W, Pacak K, Hooper D, Kopin IJ, Goldstein DS. The neuronal and extraneuronal origins of plasma 3-methoxy-4-hydroxyphenylglycol in rats. J Auton Nerv Syst, 1;50(1):93-107, Dec, 1994.

1995

656. Cizza G, Pacak K, Kvetnansky R, Palkovits M, Goldstein DS, Brady LS, Fukuhara K, Bergamini E, Kopin IJ, Blackman MR, Chrousos GP, Gold PW: Decreased stress responsivity of central and peripheral catecholaminergic systems in aged 344/N fischer rats. J Clin Invest 95:1217-24, 1995.

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657. Pacak K, Palkovits M, Kopin IJ, Goldstein DS: Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies. Frontiers in Neuroendocrinology 16:89-150, 1995.

658. Pacak K, McCarty R, Palkovits M, Cizza G, Kopin, IJ, Goldstein, DS, Chrousos GP: Decreased Central and Peripheral Catecholaminergic Activation in Obese Zucker Rats. Endocrinology 136 (10):4360-7, 1995.

659. Yadid G, Goldstein, DS, Pacak K, Kopin IJ, Golomb E. Functional alpha 3-glycine receptors in rat adrenal. Eur J Pharmacol 15;288(3):399-401, Feb, 1995.

660. Finberg JP, Wang J, Goldstein DS, Kopin IJ, Bankiewicz KS. Influence of selective inhibition of monoamine oxidase A or B on striatal metabolism of L-DOPA in hemiparkinsonian rats. J Neurochem; (3):1213-20, Sept, 1995.

661. Higgins JJ, Harvey-White JD, Kopin IJ. Low lumbar CSF concentrations of homovanillic acid in the autosomal dominant ataxias [letter]. J Neurol Neurosurg Psychiatry; 58(6):760, June,1995.

662. Eisenhofer G, Rundquist B, Aneman A, Friberg P, Dakak N, Kopin IJ, Jacobs MC, Lenders JW. Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines. J Clin Endocrinol Metab, 80(10):3009-17, Oct, 1995.

663. Pacak K, Palkovits M, Kventnansky R, Matern P, Hart C, Kopin IJ, Goldstein DS. Catecholaminergic inhibition by hypercortisolemia in the paraventricular nucleus of conscious rats. Endocrinology 136(11):4814-9, NOV, 1995.

664. Wolfovitz E, Pacak K, Abassi Z, Kopin IJ, Goldstein DS. Effects of Hypercortisolemia or hyperinsulinemia on neurochemical indices of catecholamine release and synthesis in conscious rats. J Auton Nerv Syst 4;54(2):104-12, Aug, 1995.

665. Pacak K, McCarty R, Palkovits M, Kopin IJ, Goldstein DS. Effects of immobilization on in vivo release of norepinephrine in the bed nucleus of the stria terminalis in conscious rats. Brain Res, 688(1-2):242-6, Aug,1995.

666. Kopin, IJ. Definitions of Stress and Sympathetic Neuronal Responses, In: B. Boland, Ed. Ann N Acad Sci, New York, NY, Vol 771, pp 19-30, 1995.

667. Kvetnansky R, Pacak K, Fukuhara K, Viskupic E, Hiremagalur B, Nankova B, Goldstein D S, Sabban L, Kopin I J, Sympathoadrenal System in Stress, In: B. Boland, Ed. Ann N Acad Sci, New York, NY, Vol 771, pp 131-158, 1995.

668. Pacak K, Palkovits M, Kvetnansky R, Yadid G, Kopin I J, Goldstein D S, Effects of Various Stressors on In Vivo Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and on the Pituitary-Adrenocortical Axis, In: B. Boland, Ed. Ann N Acad Sci, New York, NY, Vol 771, pp 115-139, 1995.

1996

66

669. Al-Damluji S, Kopin IJ. Functional properties of the uptake of amines in immortalised peptidergic neurones (transport-P). Brit J Pharm 117:111-8, 1996.

670. Kvetnansky R, Nankova B, Viskupic E, Vietor I, Rusnak M, McMahon A, Kopin IJ, Sabban EL. Induction of adrenal tyrosine hydroxylase mRNA by single immobilization stress occurs even after splanchnic transection and in the presence of cholinergic antagonists. J Neurochem, 66(1):138-46, Jan, 1996.

671. Lenders WM, Eisenhofer G, Abeling NGGM, Berger W, Murphy DL, Konings CH,Wagemakers LMB, Kopin IJ, Karoum F, Van Gennip AH, Brunner HG. Specific Genetic Deficiencies of the A and B Isoenzymes of Monoamine Oxidase are Characterized by Distinct Neurochemical and Clinical Phenotypes. J of Clin Inv, 97:1010-19, 1996.

672. Al-Damluji S, Kopin IJ. Binding and competitive inhibition of amine uptake at postsynaptic neurones (transport-P) by tricyclic antidepressants. British J of Pharm,117:811- 816, 1996.

673. Fukuhara K, Kvetnansky R, Weise VK, Ohara H, Yoneda R, Goldstein DS, Kopin IJ. Effects of Continuous and Intermittent Cold (SART) Stress on Sympathoadrenal System Activity in Rats. J Neuroendocrinology,8:65-72,1996.

674. Kopin, IJ. Dopaminergic Neurotransmission, In: D Robertson (Ed) Primer on the Autonomic Nervous System, Academic Press, New York, pp. 87-90,1996.

675. Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ, Goldstein DS, Murray DE. Cardiac Sympathetic Nerve Function in Congestive Heart Failure. Circulation, 93:1667-1676,1996.

676. Eisenhofer G, Lenders JWM, Harvey-White J, Ernst M, Zametkin A, Murphy DL, Kopin IJ. Differential Inhibition of Neuronal and Extraneuronal Monoamine Oxidase. Neuropsychopharm 15:296-301,1996.

677. Fukuhara K, Kvetnansky R, Cizza G, Pacak K, Ohara H, Goldstein DS, Kopin IJ. Interrelations between sympathoadrenal system and hypothalamo-pituitary- adorenocortical/thyroid systems in rats exposed to cold stress. Neuroendocrinology, 8:533-541(1996).

678. Pacak K, Palkovits M, Makino S, Kopin IJ, Goldstein D. Brainstem hemisection decrease corticotropin-releasing hormone mRNA in the paraventricular nucleus but not in the central amygdaloid nucleus. J of Neuroendocrinology, 8:543-551 (1996)

679 Yamamoto T, Polinsky RJ, Goldstein DS, Baucom CE, Kopin IJ. Plasma sulfoconjugated dopamine levels are normal in patients with autonomic failure. J Lab Clin Med. 128; 488- 491,1996.

680. Higgins JJ; Harvey-White JD; Nee LE; Colli MJ; Grossi TA; Kopin IJ Brain MRI, lumbar CSF monoamine concentrations, and clinical descriptors of patients with spinocerebellar ataxia mutations. J Neurol Neurosurg Psychiatry 61:591-5, 1996

681. Axelrod FB; Goldstein DS; Holmes C; Berlin D; Kopin IJ Pattern of plasma levels of catecholamines in familial dysautonomia. Clin Auton Res 6(4):205-9, 1996

67

682. Goldstein DS, Pacak K, Kopin IJ Nonspecificity versus Prmitive Specificity of Stress Responses. in Stress: Molecular Genetic and Neurobiological Advances Ed by McCarty R, Aguuilers, G. Sabban, E. Kvetnansky R. Gordon and Breach (1996) pp 3-19

683. Pacak K, Makino S, Palkovits M, Kvetnansky R , Kopin IJ, Goldstein DS. Immobilizatiop- induced Norepinephrine Release in the Paraventricular Nucleus and the Central Nucleus of the Amygdala; Associaton with Corticotropin-Releasing Hormone Gene-Expression in Stress: Molecular Genetic and Neurobiological Advances Ed by McCarty R, Aguuilers, G. Sabban, E. Kvetnansky R. Gordon and Breach (1996) pp 49- 66.

684. Kvetnansky R , Pacak K,Nankova B, Fukuhara K, Goldstein DS, Saban EL, Kopin IJ Peripheral Catecholamine Synthesis, ReleAse, and Metabolism during Stress: Acute versus Chronic effects of Hepercortisolemia in Stress: Molecular Genetic and Neurobiological Advances Ed by McCarty R, Aguuilers, G. Sabban, E. Kvetnansky R. Gordon and Breach (1996) pp 243-265.

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1997

685. Goldstein DS, Holmes C, Cannon RO,III, Eisenhofer G, Kopin IJ. Sympathetic cardioneuropathy in dysautonomias. N Engl J Med 1997;336:696-702.

686. Herzberg U, Elilav E, Bennett GJ, Kopin IJ. The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain. Neurosci Lett 1997;221:157-160.

687. Al-Damluji S, Porter D, Krsmanovic LZ, Knutson JR, Kopin IJ. Visual detection of transport-P in peptidergic neurones. Br J Pharmacol 120:876-882.1997.

688. Goldstein DS, Holmes C, Stuhlmuller JE, Lenders JWM, Kopin IJ. 6- [18F]Fluorodopamine positron emission tomographic scanning in the assessment of cardiac sympathoneural function--studies in normal humans. Clin Auton Res 1997;7:17- 29.

689. Herzberg U, Eliav E, Dorsey JM, Gracely RH, Kopin IJ. NGF involvement in pain induced by chronic constriction injury of the rat sciatic nerve. Neuroreport 1997; 8:1613- 8.

690. Hooper D. Kawamura M. Hoffman B, Kopin IJ, Hunyady, Mezey E, Eisenhofer G Tyrosine hydroxylase assay for detection of low levels of enzyme activity in peripheral tissues. J Chromatogr B Biomed Sci Appl 694:317-24, 1997

691. Kawamura M, Kopin IJ, Kador PF, Sato S; Tjurmina O,; Eisenhofer G. Effects of aldehyde/aldose reductase inhibition on neuronal metabolism of norepinephrine. J Auton Nerv Syst 66:145-8, 1997 1998

692. Kvetnansky R, Pacak K,; Sabban EL, Kopin IJ, Goldstein DS Stressor specificity of peripheral catecholaminergic activation. Adv Pharmacol 42:556-60, 1998

693. Goldstein DS, Holmes C, Cannon RO III, Eisenhofer G, Kopin IJ Sympathetic cardioneuropathy in dysautonomias. Adv Pharmacol 42:615-9, 1998

694. Axelrod FB, Goldstein DS, Holmes C, Kopin IJ Genotype and phenotype in familial dysautonomia.Adv Pharmacol 42:925-8, 1998

695. Kvetnansky R, Pacak K, Sabban EL, Kopin IJ, Goldstein DS. Stressor specificity of peripheral catecholaminergic activation. Adv Pharmacol. 42: 556-560, 1998

696. Kopin IJ, Rundqvist B, Friberg P, Lenders J, Goldstein DS, Eisenhofer G Different relationships among norepinephrine release, uptake and spillover in Human heart, kidneys and forearm. Am J Physiol 275: R165-R173, 1998

697. Al-Damluji S, Kopin IJ. structural properties of phenylethylamine derivatives which inhibit transport-P in peptidergic neurones. Br J Pharmacol 124: 693-702, 1998

698. Pacak K, Palkovits M, Yadid G, Kvetnansky R, Kopin IJ, Goldstein DS Heterogeneous Neurochemical Responses to Different Stressors: A Test of Selye’s Doctrine of Nonspecificity. Am J Physiol 275: R1247-R1255,1998

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699. Finberg JP; Wang J; Bankiewicz K; Harvey-White J; Kopin IJ; Goldstein DS. Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey. J Neural Transm Suppl 52:279-85, 1998

700. Castillo SO; Baffi JS; Palkovits M; Goldstein DS; Kopin IJ; Witta J; Magnuson MA; Nikodem VM. Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene. Mol Cell Neurosci 11:36-46, 1998

1999

701. Lamensdorf I, Meiri N, Harvey-White J, Jacobowitz DM, Kopin IJ Oligoantisense for Kir6.2 diminished contralateral turning induced by apomorphine in the 6-hydroxy- dopamine hemiparkinsonian rat model. Brain Research 818:,275-284, 1999

702. Kawamura M, Eisenhofer G, Kopin IJ, Kador P, Lee YS, Tsai J-Y, Fujisawa S, Lizak MJ, Sato,S. Aldose Reductase: a key enzyme in norepinephrine metabolism in rats. Biochem Pharm 58:517-524,1999

703. Duan Y-F, Kopin IJ, Goldstein DS. Stimulation of the hypothalamic paraventricular nucleus modulates firing of barosensitive neurons in the nucleus of the solitary tract in rabbits. Am J Physiol. 277:R404-R411,1999.

701. Tjurmina OA , Goldstein DS, Palkovits M, Kopin 2-Adrenoceptor-Mediated Restraintof Norepinephrine Synthesis, Release, and Turnover during Immobilization in Rats Brain Res 826:243-252,1999

702. Kawamura M, Schwartz JP, Nomura T, Kopin IJ, Goldstein DS, Huynh TT, Hooper DR, Harvey-White J, Eisenhofer G. .Differential effects of chemical sympathectomy on expression and activity oftyrosine hydroxylase and levels of catecholamines and DOPA in peripheral tissues of rats. Neurochem Res. 24:25-32, 1999.

2000

703. Sato S, Kawamura M, Eisenhofer G, Kopin IJ, Fujisawa S, Kador PF. Aldo-keto reductases in norepinephrine metabolism. Adv Exp Med Biol.463:459-63, 1999.

704. Lamensdorf I, He L, Nechushtan A, Harvey-White J, Eisenhofer G, Milan R, Rojas E, Kopin IJ. Effect of glipizide on dopamine synthesis, release and metabolism in PC12 cells.Eur J Pharmacol 388:147-54, 2000.

705. Lamensdorf I, Eisenhofer G, Harvey-White J, Hayakawa Y, Kirk K, Kopin IJ. Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, +3,4-dihydroxyphenylacetaldehydeJ Neurosci Res. 60:552-8, 2000.

706. Lamensdorf I, Eisenhofer G, Harvey-White J, Nechustan A, Kirk K, Kopin IJ. 3,4- Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells. Brain 868:191-20,2000.

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707. Lamensdorf I, Hrycyna C, He LP, Nechushtan A, Tjurmina O, Harvey-White J, Eisenhofer G, Rojas E, Kopin IJ. Acidic dopamine metabolites are actively extruded from PC12 cells by a novel sulfonylurea-sensitive transporter. Naunyn Schmiedebergs Arch Pharmacol. 2000 Jun;361(6):654-64.

708. Yadid G, Harvey-White JD, Kopin IJ, Goldstein DS. Estimation of striatal dopamine spillover and metabolism in vivo. Neuroreport. 11:3367-73, 2000

2001

709. Goldstein DS, Li ST, Kopin IJ Sympathetic neurocirculatory failure in Parkinson disease: Evidence for an etiologic role of alpha-synuclein. Ann Intern Med. 135:1010-1, 2001

2002

710. Goldstein DS, Katzper M, Linares O, Kopin IJ. Kinetic model for the fate of 6- [18F]fluorodopamine in the human heart: a novel means to examine cardiac sympathetic neuronal function. Naunyn Schmiedebergs Arch Pharmacol. 365:38-49, 2002.

711. Kawamura M, Eisenhofer G, Kopin IJ, Kador PF, Lee YS, Fujisawa S, Sato S.Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia. Auton Neurosci. 96:131-9,2002.

2003

712. Goldstein DS, Holmes C, Patronas N, Kopin IJ. Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension. Clin Sci (Lond). 2003;104:649-54.

713. Goldstein DS, Eisenhofer G, Kopin IJ. Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003 ;305:800-11.

714. Eisenhofer G, Goldstein DS, Kopin IJ, Crout JR. : rediscovery as a catecholamine-metabolizing tumor. Endocr Pathol. 2003;14:193-212.

715. Li ST, Holmes C, Kopin IJ, Goldstein DS. Aging-related changes in cardiac sympathetic function in humans, assessed by 6-18F-fluorodopamine PET scanning. J Nucl Med. 2003;44:1599-603.

2004

716. Eldadah BA, Pacak K, Eisenhofer G, Holmes C, Kopin IJ, Goldstein DS. Cardiac uptake-1 inhibition by high circulating norepinephrine levels in patients with pheochromocytoma. Hypertension. 2004 ;43:1227-32

717. Eisenhofer G, Kopin IJ, Goldstein DS. Leaky catecholamine stores: undue waste or a stress response coping mechanism? Ann N Y Acad Sci. 2004;1018:224-30.

718. Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view with implications for physiology and medicine.

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Pharmacol Rev. 2004 ;56:331-49.

719. Kopin IJ. Psychpharmacology Research in the 1950’s in Mind, Body and Behavior. Foundations of Neuroscience and Behavioral Research at the National Institutes of Health. Ed Farreras, IG, Hannaway C, and Harden VA IOS Press Washington, D.C. (2004) pp 267-280 2006

720. Goldstein DS, Eisenhofer G, Kopin IJ. Clinical catecholamine neurochemistry: a legacy of Julius Axelrod. Cell Mol Neurobiol. (2006) 26:693-700.

721. Kopin IJ. The relationship of early studies of monoamine oxidase to present concepts. J Neural Trans (2006) [Suppl} 71:79-86.

2007

722. Goldstein DS, Kopin IJ. Evolution of concepts of stress Stress. (2007)10:109-20

2008

723. Goldstein DS, Kopin IJ. Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: a meta-analysis. Endocr Regul. 2008 (4):111-9.

724. Goldstein DS, Holmes C, Sewell L, Kopin IJ. Hypertension increases cerebral 6-18F- fluorodopa-derived radioactivity J Nucl Med. 2009 (9):1479-82.

725. Goldstein DS, Holmes C, Sewell L, Pechnik S, Kopin IJ. Effects of Carbidopa and Entacapone on the Metabolic Fate of the Norepinephrine Prodrug L-DOPS J Clin Pharmacol. 2010;51:66-74

726. Goldstein DS, Sullivan P, Holmes C, Kopin IJ, Basile MJ, Mash DC. Catechols in post- mortem brain of patients with Parkinson disease. Eur J Neurol. 2010: 10.1468-1331

727. Goldstein DS, Holmes C, Kopin IJ, Sharabi Y. Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases. J Clin Invest. 2011: 121:3320-30

728. Goldstein DS, Sullivan P, Cooney A, Jinsmaa Y, Sullivan R, Gross DJ, Holmes C, Kopin IJ, Sharabi Y. Vesicular uptake blockade generates the toxic dopamine metabolite 3,4- dihydroxyplenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson’s disease. J Neurochem. 2012;123(6):932-43.

729. Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong R, Mash DC, Kopin IJ, Sharabi Y. Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease.. J Neurochem. 2013;126(5):591-603.

730. Goldstein DS, Sullivan P, Holmes C, Miller GW, Sharabi Y, Kopin IJ. A vesicular sequestration to oxidative deamination shift in myocardial sympathetic nerves in Parkinson's disease. J Neurochem. 2014:

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731. Goldstein DS, Kopin IJ, Sharabi Y. Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders. Pharmacol Ther. 2014 Dec;144(3):268-82

732. Goldstein DS, Kopin IJ, Sharabi Y, Holmes C Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy. Clin Auton Res. 2015;26:61-67

733. Goldstein DS, Sullivan P, Cooney A, Jinsmaa Y, Kopin IJ, Sharabi Y. Rotenone Decreases Intracellular Aldehyde Dehydrogenase Activity: Implications for the Pathogenesis of Parkinson Disease. J Neurochem. 2015;133:14-25

734. Goldstein DS, Sullivan P, Holmes C, Kopin IJ, Sharabi Y, Mash DC. Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy. Parkinsonism Relat Disord. 2015;21:567-72.

Irwin J. Kopin September 3, 2015

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