Profiles September 3, 2015 BIBLIOGRAPHY Irwin J. Kopin, M.D. Scientist Emeritus, Clinical Neuroscience Section National Institute of Neurological Disorders and Stroke Bethesda, Maryland 20892 1959 1. Kopin, I.J.: Tryptophan loading and excretion of 5-hydroxy-indole-acetic acid in normal and schizophrenic subjects. Science 129: 835-836, 1959. 2. Axelrod, J., Kopin, I.J. and Mann, J.D.: 3-Methoxy-4-hydroxy-phenylglycol sulfate, a new metabolite of epinephrine and norepinephrine. Biochim Biophys Acta 36: 576-577, 1959. 3. Kopin, I.J.: Discussant of "Tryptophan metabolism in schizophrenics and in controls," by E. A. Zeller. In Gibbs, F.A. (Ed.): Molecules and Mental Health. Philadelphia, J.B. Lippincot Company, 1959 (pp. 65-67). 1960 4. Kopin, I.J. and Axelrod, J.: Presence of 3-methoxy-4-hydroxy-phenylglycol and metanephrine in phaeochromocytoma tissue. Nature 185: 788, 1960. 5. Kopin, I.J.: Technique for the study of alternate metabolic pathways: Epinephrine metabolism in man. Science 131: 1372-1374, 1960. 6. Kopin, I.J., Pare, C.M.B., Axelrod, J. and Weissbach, H.: 6-Hydroxylation, the major metabolic pathway for melatonin. Biochim Biophys Acta 40: 377-378, 1960. 7. Kopin, I.J. and Axelrod, J.: 3,4-dihydroxyphenylglycol, a metabolite of epinephrine. Arch Biochem Biophys 89: 148, 1960. 8. Kopin, I.J. and Rosenberg, I.N.: Idiopathic hypoparathyroidism: Report of a case with autopsy findings. Ann Intern Med 53: 1238- 1249, 1960. 1961 1 9. LaBrosse, E.H., Axelrod, J., Kopin, I.J. and Kety, S.S.: Metabolism of 7-H3-epinephrine- D-bitartrate in normal young men. J Clin Invest 40: 253-260, 1961. 10. Hertting, G., Axelrod, J., Kopin, I.J. and Whitby, L.G.: Lack of uptake of catecholamines after chronic denervation of sympathetic nerves. Nature 189: 66, 1961. 11. Kopin, I.J., Axelrod, J. and Gordon, E.: The metabolic fate of H3-epinephrine and C14- metanephrine in the rat. J Biol Chem 236: 2109-2113, 1961. 12. Axelrod, J., Whitby, L.G., Hertting, G. and Kopin, I.J.: Studies on the metabolism of catecholamines. Circ Res 9: 715-720, 1961. 13. Axelrod, J. and Kopin, I.J.: Estimation of 0-methylated metabolites of catecholamines. In Quastel, J.H. (Ed.): Methods in Medical Research, Volume IX. Chicago: Year Book Publishers, 1961 (pp. 153-158). 14. Kopin, I.J., Pare, C.M.B., Axelrod, J. and Weissbach, H.: The fate of melatonin in animals. J Biol Chem 236: 3072-3075, 1961. 1962 15. Potter, L.T., Axelrod, J. and Kopin, I.J.: Differential binding and release of norepinephrine and tachyphylaxis. Biochem Pharmacol 11: 254-256, 1962. 16. LaBrosse, E.H., Axelrod, J., Kopin, I.J. and Kety, S.S.: The metabolism of tritium- labeled epinephrine in men. In: Tritium in the Physical and Biological Sciences, Volume II. Vienna: International Atomic Energy Agency 1962 (pp.407-412). 17. Axelrod, J., Gordon, E., Hertting, G., Kopin, I.J. and Potter, L.T.: On the mechanism of tachyphylaxis to tyramine in the isolated rat heart. Br J Pharmacol 19: 56-63, 1962. 18. Kopin, I.J., Hertting, G. and Gordon, E.K.: Fate of norepinephrine-H3 in the isolated perfused rat heart. J Pharmacol Exp Ther 138: 34-40, 1962. 19. Kopin, I.J. and Gordon, E.K.: Metabolism of norepinephrine-H3 released by tyramine and reserpine. J Pharmacol Exp Ther 138: 351-359, 1962. 1963 20. Kopin, I.J.: Estimation of relative magnitudes of alternative metabolic pathways. In Glick, D. (Ed): Methods of Biochemical Analysis, Volume XI. New York: John Wiley and Sons, Inc., 1963 (pp. 247-278). 21. Kopin, I.J. and Bridgers, W.: Differences in D- and L-norepinephrine-H3. Life Sci 5: 356-362, 1963. 2 22. Kopin, I.J. and Gordon, E.: Metabolism of administered and drug-released norepinephrine-7-H3 in the rat. J Pharmacol Exp Ther 140: 207-216, 1963. 23. Wurtman, R.J., Kopin, I.J. and Axelrod, J.: Thyroid function and the cardiac disposition of catecholamines. Endocrinology 73: 63- 74, 1963. 24. Kopin, I.J. and Axelrod, J.: The role of monoamine oxidase in the release and metabolism of norepinephrine. Ann N.Y. Acad Sci 107: 848-853, 1963. 25. Rosell, S., Kopin, I.J. and Axelrod, J.: Fate of H3-noradrenaline in skeletal muscle before and following sympathetic stimulation. Am J Physiol 205: 317-321, 1963. 26. Kopin, I.J. and Wurtman, R.J.: Flow of uterine blood and the aestrous cycle. Nature 199: 386-387, 1963. 27. Baldessarini, R.J. and Kopin, I.J.: Assay of tissue levels of S-adenosyl-methionine. Anal Biochem 6: 289-292, 1963. 28. Kopin, I.J. and Gordon, E.K.: Origin of norepinephrine in the heart. Nature 199: 1289, 1963. 29. Wurtman, R.J., Axelrod, J. and Kopin, I.J.: Uterine epinephrine and blood flow in pregnant and postparturient rats. Endocrinology 73: 501-503, 1963. 3 1964 30. Rosell, S., Axelrod, J. and Kopin, I.J.: Release of tritiated epinephrine following sympathetic nerve stimulation. Nature 201: 301, 1964. 31. Kopin, I.J.: Storage and metabolism of catecholamines: The role of monoamine oxidase. Pharmacol Rev 16: 179-191, 1964. 32. Fischer, J.E., Musacchio, J.M., Kopin, I.J. and Axelrod, J.: Effects of denervation on the uptake and ß-hydroxylation of tyramine in the rat salivary gland. Life Sci 3: 413-419, 1964. 33. Musacchio, J.M., Kopin, I.J. and Snyder, S.: Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their ß- hydroxylated metabolites. Life Sci 3: 769-775, 1964. 34. Kopin, I.J.: Metabolism of the catecholamines. Z Klin Chem 2: 115-123, 1964. 35. Fischer, J.E., Kopin, I.J. and Wurtman, R.J.: Effects of lumbar sympathectomy on the uterine uptake of catecholamines. Nature 203: 938-939, 1964. 36. Kopin, I.J., Fischer, J.E., Musacchio, J. and Horst, W.D.: Evidence for a false neurochemical transmitter as a mechanism for the hypotensive effect of monoamine oxidase inhibitors. Proc Nat Acad Sci USA 52: 716-721, 1964. 37. Glowinski, J., Axelrod, J., Kopin, I.J. and Wurtman, R.J.: Physiological disposition of H3-norepinephrine in the developing rat. J Pharmacol Exp Ther 146: 48-53, 1964. 38. Kopin, I.J.: Disposition and fate of catecholamine hormones. In Litwack, G. and Kritchevsky, D. (Eds): Actions of Hormones on Molecular Processes. New York: John Wiley and Sons, Inc., 1964 (pp. 257-267). 39. LaBrosse, E.H., Kopin, I.J., Felix, W.R., Jr. and Westlake, R.J.: Urinary tryptamine and indole-3-acetic acid excretion by schizophrenic patients: Use of the tryptamine/indole acetic acid ratio as an index of monoamine oxidase inhibition. J Psychiatr Res 2: 185-197, 1964. 40. Henkin, R.I. and Kopin, I.J.: Abnormalities of taste and smell thresholds in familial dysautonomia: Improvement with methacholine. Life Sci 3: 1319-1325, 1964. 41. Wurtman, R.J., Kopin, I.J., Horst, W.D. and Fischer, J.E.: Epinephrine and organ blood flow: Effect of hyperthyroidism, cocaine and denervation. Am J Physiol 207: 1247-1250, 1964. 1965 42. Fischer, J.E., Kopin, I.J. and Axelrod, J.: Evidence for extraneuronal binding of norepinephrine. J Pharmacol Exp Ther 147: 181-185, 1965. 43. Kopin, I.J., Fischer, J.E., Musacchio, J.M., Horst, W.D. and Weise, V.K.: False neurochemical transmitters and the mechanism of sympathetic blockade by monoamine oxidase inhibitors. J Pharmacol Exp Ther 147: 186-193, 1965. 4 44. Musacchio, J.M., Weise, V.K. and Kopin, I.J.: Mechanism of norepinephrine binding. Nature 205: 606-607, 1965. 45. Bhagat, B., Gordon, E.K. and Kopin, I.J.: Norepinephrine synthesis and the pressor responses to tyramine in the spinal cat. J Pharmacol Exp Ther 147: 319-323, 1965. 5 46. Glowinski, J., Kopin, I.J. and Axelrod, J.: Metabolism of 7-3H-norepinephrine in the rat brain. J Neurochem 12: 25-30, 1965. 47. Musacchio, J.M., Kopin, I.J. and Weise, V.K.: Subcellular distribution of some sympathomimetic amines and their ß-hydroxylated derivatives in the rat heart. J Pharmacol Exp Ther 148: 22-28, 1965. 48. Fischer, J.E., Horst, W.D. and Kopin, I.J.: ß-hydroxylated sympathomimetic amines as false neurotransmitters. Br J Pharmacol 24: 477-484, 1965. 49. Kopin, I.J., Godon, E.K. and Horst, W.D.: Studies of uptake of 1-norepinephrine-14C. Biochem Pharmacol 14: 753-759, 1965. 50. Musacchio, J.M., Fischer, J.E. and Kopin, I.J.: Effect of chronic sympathetic denervation on subcellular distribution of some sympathomimetic amines. Biochem Pharmacol 14: 898-900, 1965. 51. Kopin, I.J.: Origin disposition and metabolic fate of catecholamines. In Roth, I.J. (Ed): Isotopes in Experimental Pharmacology. Chicago: University of Chicago Press, 1965 (pp. 307- 313). 52. Fischer, J.E., Horst, W.D. and Kopin, I.J.: Norepinephrine metabolism in hypertrophied rat hearts. Nature 207: 951-953, 1965. 53. Kopin, I.J.: Estimation of alternative metabolic pathways of catecholamines in man. In Rothchild, S. (Ed): Advances in Tracer Methodology, Volume II. New York: Plenum Press, 1965 (pp. 237- 242). 1966 54. Poch, G.R. and Kopin, I.J.: The role of octopamine in tachyphylaxis to tyramine. Biochem Pharmacol 15: 210-212, 1966. 55. Fischer, J.E., Weise, V.K. and Kopin, I.J.: Release of tritiated bretylium by sympathetic nerve stimulation. Nature 209: 778-779, 1966. 56. Kopin, I.J.: Biochemical aspects of release of norepinephrine and other amines from sympathetic nerve endings. Pharmacol Rev 18: 513-523, 1966. 57. Musacchio, J.M., Fischer, J.E. and Kopin, I.J.: Subcellular distribution and release by sympathetic nerve stimulation of dopamine and a-methyl dopamine. J Pharmacol Exp Ther 152: 56-61, 1966. 58. Musacchio, J.M., Goldstein, M., Anagnoste, B., Poch, G.