October, 4th - 5th 2013 , Russian Federation

INTERNATIONAL CONFERENCE

NUCLEAR AND PERSONALIZED MEDICINE DEVELOPMENT IN THE DIAGNOSIS AND TREATMENT OF CANCER

Tatarstan Cancer Center Dear friends, During past 2 years 7 Positron Emission Tomography Centers were put into operation in the territory of the Russian Federation and 6 PET centers are to be opened within the coming 2 years. The intensity of molecular diagnostics methods development enables us to face the future with confidence and optimism. Nevertheless, We are sure that PET centers opening may not serve a key to building an effective system. In order to integrate the Nuclear medicine methods at a maximum capacity level it is necessary to maintain the following components of success: staff training, adjustment of the logistics, interdisciplinary and integrated approach to proper functioning of PET centers. Besides, current trends in the cancer care medicine make us use a strictly individualized approach to the management of each patient. There is no doubt, that nowadays the personalized medicine highly promotes the development of cancer medicine. It is the demand for personalization of each treatment method that forces the scientific community to advance in achievement of new horizons for state of the art oncology. The forthcoming international conference «Nuclear and Personalized Medicine development in the diagnosis and treatment of cancer», that will take place in Kazan, October 4-5th, is going to provide Russian specialists and their colleagues from countries of the near abroad the benefit of invaluable experience of work in the field of molecular visualization methods, as well as personalized medicine from the world’s leading practitioners. Such conference will be held in the Russian Federation for the first time. We think that subject matter of the conference will be of interest for representatives of different specialties: oncologists, radiologists, chemotherapeutists, cardiologists, public health îfficials and others. Cancer Center is a long-term partner of OECI, which is a network of leading European Cancer Institutes, aimed at improvement of quality of cancer patients centered care, consolidation of joint work in the sphere of diagnostics, treatment and rehabilitation. The conference will be held in close collaboration with the OECI, which means a topmost level of research and organizational parts of the future event. We would like to invite you to take part in the conference «Nuclear and Personalized Medicine development in the diagnosis and treatment of cancer» which will be held on 4-5th of October, 2013 in Kazan. We are sure that experience and knowledge gained at the conference will allow us to make a quantum leap in the improvement of cancer patients care (cancer care or care of cancer patients). The Organizing Committee Organizers: • The Association of Oncologists of • The Organization of European Cancer Institutes (OECI) • Ministry of Health of the Republic of Tatarstan • Tatarstan Cancer Center

The congress will be dedicated to the most controversial subjects in state of the art oncology, which are nuclear medicine, as well as personalized medicine. Development of those areas will allow improving significantly the quality, safety and cost-effectiveness of care of cancer patients. Following issues are to be discussed during the conference: 1. Nuclear medicine development in the world and in the Russian Federation. 2. Practical application of Positron Emission Tomography methods in oncological practice. 3. State support of technologies development in the Russian Federation. Issues of PET centers licensing. Financing of PET researches. 4. Organization of PET centers activities (juridical, legal and financial aspects). 5. Introduction of molecular and genetic researches into routine practice of Russian cancer care facilities. 6. Practical approaches to development and improvement of personalized medicine and its development in the Russian Federation. 2 Plenary session with participation of the world’s leading experts in the areas of personalized and nuclear medicine is planned to be held on 4th of October. On 5th of October two simultaneous sessions are planned (Nuclear medicine and Personalized medicine) The congress will be attended by key specialists of leading cancer institutes and centers of Europe, former CIS countries, as well as leading Russian specialists in the sphere of nuclear medicine and personalized medicine as well. General information

Tatarstan Cancer Center For over 66 years the Tatarstan Regional Clinical Cancer Center has given hope and life to thousands of cancer patients. Our center used to be one of the key institutions of Soviet Union and nowadays it is keeping leading positions not only on the territory of Russian Federation, but also on the territory of Former Soviet Union countries. Tatarstan Regional Clinical Cancer Center is in charge of cancer care situation in the Republic of Tatarstan. It means that our Cancer Center provide specialized treatment for more than 4 million people that live in the territory of 67 836 square meters. Every 54th inhabitant of Tatarstan is now being followed-up in Tatarstan Regional Clinical Cancer Center with diagnosis of cancer (overall amount – 70 057 patients). Tatarstan Regional Clinical Cancer Center has its branches in Kazan, Almetyevsk and Naberezhnye Chelny and has 1153 beds for patients, which means that the Center is designed for the treatment of 1153 cancer patients simultaneously. More than 25000 patients receive inpatient treatment in our Cancer Center. More than 15000 wide range surgeries are provided here each year. The modern, up-to-date equipped and completely reconstructed Center of Nuclear Technologies was re-opened in 2011 and is able to provide patients with following diagnostic and treatment options: distant radiotherapy, brachitherapy, specialized computer tomography, SPECT-scanning, CT scanning, PET/CT etc. Preventive care and patient education campaigns are regularly organized in our Cancer Center, such as School for Cancer Patients, School for Cancer Patient Caregivers, Newspaper “Vestnik Zdorovya” (Health Bulletin) is released monthly, and different types of screening progr ams are carried out. Tatarstan Regional Clinical Cancer Center is the leading cancer center on the Volga district of Russian Federation. Chief physician of TRCCC Professor Rustem Khasanov is the head of the Volga District Cancer Institutes and Centers Association. Association involves 15 cancer centers and institutes that together provide treatment for more than 31 million people. The Organisation of European Cancer Institutes Established in 1977 to promote greater cooperation among European cancer centres and institutes in the field of cancer collaborative research, the “Organisation of European Cancer Institutes” in 2005 the Organisation was remodelled into OECI-EEIG “Organisation of European Cancer Institutes – European Economic Interest Grouping”, so to keep with the on-going European developments.

3 The OECI Central Office is located in Brussels while the Coordinating Secretariat and Liaison Office is located in Genoa. The OECI is a network presently regrouping 70 cancer centres and institutions across Europe, dynamically working in crosscut expertise projects organised by involving the OECI Working Groups, Activities and Members. Currently, there are 6 main Working Groups and 2 Activities. A coordination among cancer institutes at a European level can contribute to the production and dissemination of knowledge in order to reduce fragmentation, increase competitiveness with the ultimate goal to find new and better treatments, provide more comprehensive care and improve patients' quality of life through an evidence-based medicine with a holistic approach. In order to have a significant impact on the quality of care, the OECI has the objective to include 50% of the membership of the OECI in its Accreditation/Designation programme within 2015. Up to September 2013, 10 OECI Members received the OECI Accreditation and Designation certificate and 18 Members are into the process. The certified Members represent the so called “OECI QUALITY PROGRAMME AND NETWORK”. As a European Organisation of Cancer Centres, the OECI works on organisational expertise and improvement, in order to strengthen the operational structure that facilitates translational research and integrated care. In addition to the Accreditation/Designation programme, a detailed and focused benchmarking on services among members is under development in order to transfer best practices to the cancer community.Educational activities aim to strengthen the translational capabilities and to disseminate innovation in cancer care. A special programme on educational activities in Central and Eastern European Countries is under development. In view of the crucial role of the pathology departments, of the expected “flood” of new markers and diagnostics in a scope of “OMICS”, the OECI already acts in close cooperation with the European Association for Cancer Research, the IMPACTS network, the European Society of Pathology, the EORTC.

Kazan Kazan is one of the major Russian cities, significant economical, political, scientific and cultural center. It lies on the Volga River in European Russia, 800 km east of . Population of Kazan city is over 1 million people; it is the sixth largest city in Russia. Kazan is the capital city of the Republic of Tatarstan, one of the

highly developed republics of the Russian Federation from the economic point of view. Kazan has a 1000 year history, rich with cultural and historical monuments, and the Kazan Kremlin is a UNESCO World Heritage Site. Kazan is an attractive city to Russians and foreign tourists, who like to come more and more every year. The city is famous for its Opera and Ballet theaters, Art museums, International festivals, libraries, the newest technologies and strong scientific potentials. Archeological excavations on the territory of Kazan Kremlin provided evidence that the first fortress of Kazan was founded at the turn of Xth–XIth centuries by Volga Bulgars. In 1438 Kazan became the capital of Khanate of Kazan, in 1552 the city was conquered by Ivan IV and became a significant and integral part of the Russian state. The famous Kazan Kremlin was built after the siege of Kazan on the ruins of the former castle. The wall and towers of Kazan Kremlin, including the remarkable Spasskaya Tower over the main entrance, were mostly built by master builders from Pskov, a city on the north-west of Russia, and thus it shares common features with the Pskov Kremlin. 4 Later, in 17th-18th century, the most familiar landmark and architectural symbol of Kazan, the leaning Soyembika Tower, was built. There are both ancient and modern buildings among numerous Kazan Kremlin sights. The oldest one is the Annunciation Cathedral built in 1554-1562, and the newest one is the Qolþarif mosque built in 1996-2005 in place of the mosque destroyed in 1552. Lots of landmarks are located outside the Kazan Kremlin in downtown. Impressive churches and mosques of XVI–XIXth centuries are displaying various architectural styles and cobine features of both the Russian and Tartar traditions, resulting in unique historical monuments. The most popular among tourists are the central Kremlyovskaya and Baumana streets, which feature XIXth century buildings, though the majority of Kazan historical environment was comprised of wooden two-storey buildings that were destroyed during «The liquidation of ramshackle apartments» program, which improved the citizens’ living conditions and modernized the city’s appearance. Kazan has one of the oldest Russian universities, a branch of the Russian Academy of Sciences and a number of academical institutes. Kazan State University was founded in 1804 and is the second oldest university in Russia. Many distinguished scientists worked at KSU: the famous Russian mathematician Nikolai Lobachevsky, who was the founder of non-Euclidian geometry, was its rector; Aleksandr Butlerov, Vladimir Markovnikov, Aleksandr Arbuzov, who were the fathers of organic chemistry; the Polish linguist Jan Baudouin de Courtenay. The KSU is known as the birthplace of Electron Spin Resonance due to the work of Evgeny Zavoisky. The university is still named after its most famous alumnus Vladimir Ulianov-Lenin. Kazan Scientific Center was founded in 1945 as a branch of the Russian Academy of Sciences. It includes 5 research institutes including the Kazan Institute of Biochemistry and Biophysics and the A.E. Arbuzov Institute of Organic and Physical Chemistry.

Hotel accomodation Korston hotel provides variety of services and facilities, combined with a spectacular view over the thousand-year-old city of Kazan from your comfortable modern room equipped to the latest technological standards.

The hotel is located in a beautiful greenarea of a city park within 10 minutes walk to the Kazan city center and 20 minutes walk to Kazan Kremlin. The Hotel offers 400 rooms. 6 restaurants and bars. Entertainment centre featuring bowling, billiard, cinema, children park and fitness centre. 14 fully equipped conference halls.

Transport Kazan International Airport The Kazan International Airport is the only airport in the capital of Tatarstan. It is located 26 kilometers away to the south-east of the city. At present the airport handles around 1 million passengers a year and operates flights to cities in Russia and abroad.

5 Railway Station With over 8 million passengers a year, Kazan’s railway station is Tatarstan’s busiest railway station in terms of passenger throughput. The trains from Siberia, Far East, Volga Region, Central Russia pass through the Kazan Railway Station. Buses Kazan’s bus depot is composed of comfortable buses made in Russia (NefAz, MAZ) and China (Higer, Golden Dragon). Since 2007 more than 2,500 outdated buses were taken out of service and are being gradually replaced by high-capacity buses that meet Euro 3 requirements. This enables to reach a higher level of security, significantly lessen volume of city traffic and thus improve the city’s environment. Trolley buses The majority of trolley buses functioning in Kazan were made in Russia. Almost all vehicles are of a high capacity, have 3 stages of illumination and an improved ventilation system. Right now a trolley bus is an environmentally friendly means of transport with a convenient schedule (every 8-10 minutes) and almost 24/7 service. Underground This is the youngest mode of transport in Kazan. The first underground line was opened in 2005. It is composed of 7 stations. The most recent one is the Kozya Sloboda (‘Goat Settlement’) station opened in 2010 that connected two banks of the Kazanka River. Taxi There are more than 20 taxi services in Kazan. Taxi can be ordered to any place 24/7. Moreover, you can catch a running free taxi by lifting your hand. LIST OF TAXI Climate In the beginning of October, you can expect an average low of 5,65 C and an average high of 12,55 C. Monthly mean temperature 9,15 C. Currency and credit cards Monetary unit: Russian ruble. Shops, restaurants and banks of Kazan accept for payment all kind of credit cards.

Conference-specific information The official language is Russian with simultaneous translation in English during the sessions. Lunches and breaks will be organized in the congress venue. No registration fee on the conference.

Online registration via www.oncort.ru

Contact information: Tatarstan Cancer Center 29, Sibirskiy tract, Kazan, Russia, 420029 www.oncort.ru

Zhavoronkov Vladimir Head of International Services Division phone +7(843) 5257397 mobile +7 9033070870 E-mail: [email protected] 6 ÏÓÒÈ ÐÀÇÂÈÒÈß ÌÅÒÎÄΠßÄÅÐÍÎÉ ÌÅÄÈÖÈÍÛ È ÏÅÐÑÎÍÀËÈÇÈÐÎÂÀÍÍÛÕ ÏÎÄÕÎÄΠ ÄÈÀÃÍÎÑÒÈÊÅ È ËÅ×ÅÍÈÈ ÇËÎÊÀ×ÅÑÒÂÅÍÍÛÕ ÍÎÂÎÎÁÐÀÇÎÂÀÍÈÉ

PROGRAM NUCLEAR AND PERSONALIZED MEDICINE DEVELOPMENT IN THE DIAGNOSIS AND TREATMENT OF CANCER

October, 4th -5 th 2013

Friday, October 4th 2013

PLENARY SESSION 1:

National Cancer Plans in the Russian Federation and Western Europe

Chairs: Adel Vafin, Marco Pierotti, Rustem Hasanov Adel Vafin, Introductory Notes from Ministry of Health of 9.00-9.10 Minister of Health of the Tatarstan Republic of Tatarstan, Russia

Marco Pierotti , 9.10-9.20 Welcome note OECI, Past President; National Cancer Institute Milan, Italy Rustem Hasanov, 9.20-9.35 Cancer Care in Tatarstan Director of Tatarstan Cancer Center, Kazan, Russia

Prof. Valeriy Starinskiy, Enhancement of the Cancer Care System in the Deputy Director P.A. Gertsen 9.35-9.55 Russian Federation Moscow Research Institute of Oncology, Russia Francesco Cicone, Member of the Young EANM Bioimaging and Nuclear Medicine development: 9.55-10.15 Committee, Sant'Andrea highlights and innovative approaches Hospital, "Sapienza" University of Rome, Italy

Marco Pierotti, Accreditation of Comprehensive Cancer Centres in 10.15-10.35 OECI, Past President; National Europe Cancer Institute Milan, Italy 10.35-11.00 Discussion/Concluding Remarks

BREAK

7 PLENARY SESSION 2: Bioimaging - Needs & Challenges

Chairs: Benedikt Engels, Svyatoslav Medvedev, Refat Kurtasanov

European Radiotherapy Oncopolicy in the coming Philip Poortmans, 11.30-11.50 years ESTRO President Elect

Svyatoslav Medvedev, Chief of PET center of the 11.50-12.10 PET Centre Management in the Russian Federation Institute of the Human Brain, Russian Academy of Sciences, Moscow, Russia Galina Kodina, State of the Art of Registration and Medical Use of 12.10-12.30 A.I. Burna zyan Federal Medical Radiotracers & Biophysical Center, Moscow, Russia Impact of PET-CT scan in cancer treatment: stand- Benedikt Engels, 12.30-12.50 Oncologic Center UZBrussel, point of the radiation oncologist Brussels, Belgium 12.50-13.10 Discussion/Concluding Remarks

LUNCH

PLENARY SESSION 3: Personalised Medicine: New Horizons in Oncology

Chairs: Angelo Paradiso (OECI), Elena Artamonova, Ildar Gilyazutdinov Elena Artamonova, Dept of New Anticancer Drug 15.00-15.20 Personalised Medicine in the Russian Federation Investigation, N.N.Blokhin Rus- sian Cancer Research Centre, Moscow, Russia Marco Pierotti, 15.20-15.30 Personalised Medicine in European countries OECI, National Cancer Institute Milan, Italy Angelo Paradiso, 15.30-15.50 Analytical/Clinical Validation of New Biomarkers OECI, NCRC Bari, Italy Irina Demidov a, 15.50-16.10 Personalised Medicine: the view of a Geneticist Moscow city Cancer Hospital ¹62, Russia Gabriella Pravettoni, 16.10-16.30 Management and Patient Involvement/Information University of Milan/IEO Lev Demidov, 16.30-16.50 Personalised approach in melanoma N.N.Blokhin Russian Cancer Research Centre, Moscow, Russia

16.50-17.00 Discussion/Concluding Remarks

KAZAN CITY TOUR CONFERENCE DINNER

8

Saturday, October 5th 2013

SCIENTIFIC CONFERENCE

SESSION A: Nuclear/Bioimaging: Practical Problems

Chairs: Stefano Canitano, Galina Kodina, Mikhail Burmistrov, Eugeniy Puzakin Perspectives of PET technologies and theranos- Galina Kodina, 9.00-9.30 tics development on the base of homeland ge- A.I. Burnazyan Federal Medical & nerator Ga-68 Biophysical Center, Moscow, Russia Re fat Kurtasanov, How to organise a PET department 9.30-10.00 Tatarstan Cancer Center, Kazan, Russia What the clinician must know about PET: Stefano Canitano, 10.00-10.20 Pro and cons. European specialists point of view NCI Regina Elena, Rome, Italy Elena Dizendorf, What the clinician must know about PET: 10.20-10.40 Medical director of Philips in Russian Pro and cons. Russian specialists point of view Federation 10.40-11.00 Discussion/Concluding Remarks

BREAK Andrey Stanzhevskiy, Russian Research Centre for Radiology 11.30-11.50 PET in diagnosis and staging and Surgical Technologies, Moscow, Russia Onelio Geatti, 11.50-12.20 PET in follow-up President Italian Association of Nuc- lear Medicine; University Hospital Udine, Italy Mikhail Dubrovin, Genetic Markers for risk, diagnosis and therapy 12.20-12.40 Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 12.40-13.00 Discussion/Concluding Remarks LUNCH Sergei Shiryaev, PET in the diagnosis of neuroendocrine tu- Departme nt of radionuclide diagnostics 14.00-14.20 mors and therapy. N.N.Blokhin Russian Can- cer Research Center, Moscow, Russia Tatyana Skvorcova, Neurovisualisa- 14.20-14.40 PET in Neurooncology tion Laboratory, Institute of the Hu- man Brain, Moscow, Russia Onelio Geatti, FDG-PET-CT in the differential diagnosis of President Italian Association of Nuclear 14.40-15.00 pulmonary nodules Medicine; University Hospital Udine, Italy 15.00-15.30 Discussion/Concluding Remarks

BREAK

9 Vladimir Chernov, 16.00-16.20 Scintigraphic diagnostics of breast cancer Nuclear Medicine Dept, Tomsk Cancer Research Institute, Russia Aleksey Rizhkov, 16.20-16.40 SPECT-CT in bone cancer diagnostics Radionuclide Diagnostics & Therapy Dept, N.N. Blokhin Russian Cancer Re- search Centre, Moscow, Russia Ivan Sinilkin, Scintigraphic visualisation of sentinel lymph 16.40-17.00 Nuclear Medicine, Dept, Tomsk Cancer nodes of different localisations Research Institute, Russia Radionuclide therapy of bone metastases with Maksim Smolyarchuk, Department of radionuclide diagnos- 17.00-17.20 russian 188Re-labeled bone-seeking radio- pharmaceuticals. tics, Medial Radiological Scientific Centre, Obninsk, Russian Federation 17.20-17.30 Discussion/Concluding Remarks

SESSION B: Personalised Medicine

Chairs: Giorgio Stanta, Sergei Moshkovskiy, Semen Petrov, Foat Ahmetzyanov Vitaliy Prutski, Head of Center Personalised Medicine in Russia. View of a on bioinformatics 9.00-9.20 and prognostic medicine, Researcher Moscow, Russia Aleksander Rudin, Personalised Medicine in Russia. View of a 9.20-9.40 Head of marketing division of the Russian pharmaceutical producer hospital products department, Veropharm company, Moscow, Russia Aleksey Nikitin, Molecular-genetic methods of diagnostic in Federal scientific-clinical center of 9.40-10.00 practical medicine: approaches comparison Federal Medico-Biological Agency, Moscow, Russia 10.00-10.20 Discussion/Concluding Remarks BREAK The role of biobanks in the development of Giorgio Stanta, 11.00-11.20 personalised cancer medicine OECI, University of Trieste, Italy Semen Petrov, Molecular Pathology biomarkers in the 11.20-11.40 Tatarstan Cancer Center, personalised treatment of cancer patients Kazan, Russia Ludmila Lubchenko, The experience of molecular-genetic diagnostics Laboratory of Clinical Genetics, 11.40-12.00 introduction in cancer of the female reproductive N.N. Blokhin Russian Cancer Re - system search Centre, Moscow, Russia Evgeniy Imyanitov, Molecular diagnostics of colorectal cancer. Molecular Genetic s Laboratory, 12.00-12.20 Practical approaches N.N.Petrov Oncology Research In- stitute, Saint-Petersburg, Russia 12.20-12.50 Discussion

LUNCH

10

Sergei Moshkovskiy, Orekhovich Institute of Biomedical 14.00-14.20 Proteomics in Personalised medicine Chemistry of the Russian Academy of Medical Sciences, Moscow, Russia

Sergio Roman-Roman, Reverse Phase Protein Array: adressing signaling Translational Research 14.20-14.40 disregulation in cancer Department, Institut Curie, Paris, France

Vasyl F. Chekhun, R.E. Kavetsky Institute of Systematic biology as a base of a paradigm of Experimental Pathology, Oncology 14.40-15.00 diagnostic and treatment of cancer patients and Radiobiology, National chan ge Academy of Sciences, Kiev, Ukraine 15.00-15.20 Discussion BREAK Evgeniy Imyanitov, EGFR gene mutation diagnostic for the choosing Molecular Genetics Laboratory, 15.50-16.10 NSCLC method of therapy N.N. Petrov Oncology Research Institute, , Russia

Rashida Orlova, Recent methods of diagnostics and treatment of 16.10-16.30 Saint-Petersburg clinical cancer metastatic CRC centre, Russia

Valerii Breder, Personalized medicine in the treatment of NSCLC 16.30-16.50 N.N.Blokhin Russian Cancer Re- development search Centre, Moscow, Russia Konstantin Borisov, Personalized medicine in the treatment of NSCLC 16.50-17.10 Hospital products department, development Veropharm company, Moscow, Russia

17.10-17.30 Discussion

END OF CONFERENCE

11 For notes

12 For notes

13