BMC Genomics BioMed Central Research article Open Access Two-transcript gene expression classifiers in the diagnosis and prognosis of human diseases LucasBEdelman1,2,6, Giuseppe Toia1,2, Donald Geman4, Wei Zhang5 and Nathan D Price*1,2,3 Address: 1Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA, 2Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA, 3Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA, 4Department of Applied Mathematics and Statistics & Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland 21218, USA, 5Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA and 6Babraham Institute, Cambridge, CB22 3AT, UK Email: Lucas B Edelman -
[email protected]; Giuseppe Toia -
[email protected]; Donald Geman -
[email protected]; Wei Zhang -
[email protected]; Nathan D Price* -
[email protected] * Corresponding author Published: 5 December 2009 Received: 13 May 2009 Accepted: 5 December 2009 BMC Genomics 2009, 10:583 doi:10.1186/1471-2164-10-583 This article is available from: http://www.biomedcentral.com/1471-2164/10/583 © 2009 Edelman et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Identification of molecular classifiers from genome-wide gene expression analysis is an important practice for the investigation of biological systems in the post-genomic era - and one with great potential for near-term clinical impact.