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(R)-Methanandamide (R)-Methanandamide sc-200792 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME (R)-Methanandamide STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH0 HAZARD INSTABILITY0 SUPPLIER Company: Santa Cruz Biotechnology, Inc. Address: 2145 Delaware Ave Santa Cruz, CA 95060 Telephone: 800.457.3801 or 831.457.3800 Emergency Tel: CHEMWATCH: From within the US and Canada: 877-715-9305 Emergency Tel: From outside the US and Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 PRODUCT USE Stable anandamide analog that is a selective agonist for the CB1 (cannabinoid) receptor (Ki values are 20 and 815 nM for CB1 and CB2 receptors respectively). Also displays agonist activity at vanilloid receptors. The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. They are found mainly in the terminals of central and peripheral neurons where they usually mediate inhibition of neurotransmitter release. They can also be present on some non-neuronal cells, including immune cells. SYNONYMS C23-H39-N-O2, C23-H39-N-O2, "(R)-N-(2-hydroxy-1-methylethyl)-5Z, 8Z, 11Z, 14Z-eicosatetraenamide", "(R)-N-(2- hydroxy-1-methylethyl)-5Z, 8Z, 11Z, 14Z-eicosatetraenamide", "N-((1R)-2-hydroxy-isopropyl)(5Z, 8Z, 11Z, 14Z)eicosa-5, 8, 11, 14-", tetraenamide, "N-((1R)-2-hydroxy-isopropyl)(5Z, 8Z, 11Z, 14Z)eicosa-5, 8, 11, 14-", tetraenamide, "(R)-(+)- arachidonyl-1' -hydroxy-2' -propylamide", "(R)-(+)-arachidonyl-1' -hydroxy-2' -propylamide", "cannabinoid receptor agonist", "vanilloid receptor agonist", "anandamide analogue" Section 2 - HAZARDS IDENTIFICATION CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Harmful: danger of serious damage to health by prolonged exposure through inhalation. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ■ The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the individual, following ingestion, especially where pre- existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, unintentional ingestion is not thought to be cause for concern. EYE ■ Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals. SKIN ■ The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. ■ Open cuts, abraded or irritated skin should not be exposed to this material. ■ Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ■ The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. ■ Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. CHRONIC HEALTH EFFECTS ■ Harmful: danger of serious damage to health by prolonged exposure through inhalation. This material can cause serious damage if one is exposed to it for long periods. It can be assumed that it contains a substance which can produce severe defects. This has been demonstrated via both short- and long-term experimentation. Exposure to the material may cause concerns for human fertility, on the basis that similar materials provide some evidence of impaired fertility in the absence of toxic effects, or evidence of impaired fertility occurring at around the same dose levels as other toxic effects, but which are not a secondary non-specific consequence of other toxic effects. Chronic oral doses of cannabinoids induce testicular atrophy in rats. Rats administered marijuana, via inhalation through a smoking machine, had significantly lower sperm counts and an increased number of abnormal sperm. Cannabinoids are embryotoxic. Treatment with cannabinoids during the first two-thirds of gestation is associated with increased frequency of foetal resorption and decreased birth weights in mice, rats, rabbits and hamsters. The weight of accumulated evidence suggests that the cannabinoids are immunotoxic; they regulate the immune system and may produce adverse pharmacological effects. Immune system receptors appear to be the targets of cannabinoids. At least two receptors are involved in binding of cannabinoids: one, CB1 is located within the brain, while CB2 is predominantly expressed in the periphery, especially in cells of the immune system. Cannabinoid receptors have been found in human spleen, tonsils, and peripheral lymphocytes. Observations of an increased incidence of viral infections and also of allergic reactions, in marijuana users, have been supported by the results of animal studies. Several studies demonstrate the suppression of resistance against a variety of organisms. Results indicate that cannabinoids affect T cells, B cells, NK (natural killer) cells, and macrophages. This may explain the reduced host resistance to viruses, parasites, and certain intracellular bacteria. The cannabinoids are implicated in the suppression of antibody response to specific antigens. They appear to alter both humoral and cell-mediated responses. Although specific tetrahydrocannabinoid (THC) receptors occur naturally in the cerebellum, basal nuclei, and hippocampus of the human brain, not all THC derivatives are pharmacologically active. Those that are produce a morphine-like effect. Psychoactive cannabinoids cause euphoria in humans and have addictive liability in vulnerable individuals. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS HAZARD RATINGS Min Max Flammability: 1 Toxicity: 0 Body Contact: 0 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 2 Extreme=4 NAME CAS RN % (R)-(+)-methanandamide 157182-49-5 >98 Section 4 - FIRST AID MEASURES SWALLOWED ■ Immediately give a glass of water. First aid is not generally required. If in doubt, contact a Poisons Information Center or a doctor. EYE ■ If this product comes in contact with eyes: Wash out immediately with water. If irritation continues, seek medical attention. Removal of contact lenses after an eye injury should only be undertaken by skilled personnel. SKIN ■ If skin or hair contact occurs: Flush skin and hair with running water (and soap if available). Seek medical attention in event of irritation. INHALED ■ If fumes or combustion products are inhaled remove from contaminated area. Other measures are usually unnecessary. NOTES TO PHYSICIAN ■ Treat symptomatically. Section 5 - FIRE FIGHTING MEASURES Vapour Pressure (mmHG): Negligible Upper Explosive Limit (%): Not Available Specific Gravity (water=1): Not Available Lower Explosive Limit (%): Not Available EXTINGUISHING MEDIA ■ Foam. Dry chemical powder. BCF (where regulations permit). Carbon dioxide. Water spray or fog - Large fires only. FIRE FIGHTING ■ Alert Emergency Responders and tell them location and nature of hazard. Wear breathing apparatus plus protective gloves. Prevent, by any means available, spillage from entering drains or water course. Use water delivered as a fine spray to control fire and cool adjacent area. DO NOT approach containers suspected to be hot. Cool fire exposed containers with water spray from a protected location. If safe to do so, remove containers from path of fire. Equipment should be thoroughly decontaminated after use. GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS ■ Combustible solid which burns but propagates flame with difficulty. Avoid generating dust, particularly clouds of dust in a confined or unventilated space as dusts may form an explosive mixture with air, and any source of ignition, i.e. flame or spark, will cause fire or explosion. Dust clouds generated by the fine grinding of the solid are a particular hazard; accumulations of fine dust may burn rapidly and fiercely if ignited. Dry dust can be charged electrostatically by turbulence, pneumatic transport, pouring, in exhaust ducts and during transport. Build-up of electrostatic charge may be prevented by bonding and grounding. Powder handling equipment such as dust collectors, dryers and mills may require additional protection measures such as explosion venting. Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), nitrogen oxides (NOx), other pyrolysis products typical of burning organic material. May emit poisonous fumes. FIRE INCOMPATIBILITY ■ Avoid contamination with oxidizing
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