Ganoderma Lucidum Improves Physical Fitness in Women with Fibromyalgia Daniel Collado Mateo1, Francesco Pazzi1, Francisco J

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Ganoderma Lucidum Improves Physical Fitness in Women with Fibromyalgia Daniel Collado Mateo1, Francesco Pazzi1, Francisco J Nutr Hosp. 2015;32(5):2126-2135 ISSN 0212-1611 • CODEN NUHOEQ S.V.R. 318 Original / Alimentos funcionales Ganoderma lucidum improves physical fitness in women with fibromyalgia Daniel Collado Mateo1, Francesco Pazzi1, Francisco J. Domínguez Muñoz1, Juan Pedro Martín Martínez1, Pedro R. Olivares2, Narcis Gusi1 and José C. Adsuar1 1Faculty of Sport Science, University of Extremadura, Cáceres, Spain. 2Instituto de Actividad Física y Salud, Universidad Autónoma de Chile, Chile. Abstract GANODERMA LUCIDUM MEJORA LA CONDICIÓN FÍSICA EN MUJERES CON Introduction: fibromyalgia is a chronic disease charac- FIBROMIALGIA terized by generalized pain, stiffness, poor physical con- ditioning, non-restorative sleep and poor health-related quality of life. Ganoderma lucidum a type of mushroom Resumen that has demonstrated several benefits in different po- Introducción: la fibromialgia es una enfermedad cróni- pulations. Ceratonia siliqua is a natural therapy rich in ca caracterizada por dolor crónico general, rigidez, con- antioxidants with potential benefits on health. dición física pobre, sueño no reparador y mala calidad Objective: to evaluate the effects of 6-week treatment de vida relacionada con la salud. Ganoderma lucidum es of Ganoderma lucidum and Ceratonia siliqua on physical un tipo de hongo que ha demostrado tener diferentes be- fitness in patients suffering from fibromyalgia. neficios en diversas poblaciones. La harina de algarrobo Methods: sixty-four women with fibromyalgia partici- (Ceratonia siliqua) es una fuente natural de antioxidantes pated in the study. They took 6 g of Ganoderma lucidum con potenciales beneficios para la salud. or Ceratonia siliqua per day for 6 weeks. Different fitness Objetivo: evaluar los efectos sobre la condición física tests were selected in order to evaluate functional capa- en mujeres con fibromialgia de un tratamiento de seis se- city. manas con Ganoderma lucidum y compararlos con los de Results: after the 6-week treatment period, Ganoder- un tratamiento con Ceratonia siliqua. ma lucidum significantly improved aerobic endurance, Métodos: sesenta y cuatro mujeres con fibromialgia lower body flexibility, and velocity (p < .05). No signifi- participaron en el estudio. Se hicieron dos grupos, el cant improvement in any physical test was observed in primer grupo tomó 6 g diarios de Ganoderma lucidum, the Ceratonia siliqua group. mientras que el segundo tomó 6 g diarios de Ceratonia Discussion and conclusion: Ganoderma lucidum may siliqua. Se evaluó la condición física mediante diferentes improve physical fitness in women with fibromyalgia, test físicos validados. whereas, Ceratonia siliqua seemed to be ineffective at in- Resultados: después de seis semanas de tratamiento, creasing physical fitness. These results may indicate that Ganoderma lucidum mejoró significativamente la resis- Ganoderma lucidum might be a useful dietary supple- tencia aeróbica, la flexibilidad del miembro inferior y la ment to enhance physical performance of the patients velocidad (p < 0,05). Por otro lado, Ceratonia siliqua no suffering from fibromyalgia. mejoró la condición física. (Nutr Hosp. 2015;32:2126-2135) Discusión y conclusiones: Ganoderma lucidum puede mejorar la condición física en mujeres con fibromialgia, DOI:10.3305/nh.2015.32.5.9601 mientras que Ceratonia siliqua parece no ser efectivo Key words: Chronic pain. Reishi. Ceratonia siliqua. Ga- para este propósito. Estos resultados pueden indicar que noderma lucidum. Nutrition. Endurance. Velocity. 6 g diarios de Ganoderma lucidum podrían ser un suple- mento útil para mejorar la condición física en esta po- blación. (Nutr Hosp. 2015;32:2126-2135) DOI:10.3305/nh.2015.32.5.9601 Palabras clave: Dolor crónico. Reishi. Ceratonia siliqua. Ganoderma lucidum. Nutrición. Resistencia. Velocidad. Correspondence: Pedro R. Olivares. Instituto de Actividad Física y Salud, Universidad Autónoma de Chile, Chile. E-mail: [email protected] Recibido: 7-VII-2015. Aceptado: 7-VIII-2015. 2126 031_9601 El Ganoderma lucidum mejora.indd 2126 8/10/15 2:41 Introduction Ceratonia siliqua (CS) is a natural therapy that has been consumed in many Mediterranean countries in Fibromyalgia (FM) is a chronic rheumatic disease culinary preparations of beverages and confectionery. of unknown etiology. It is characterized by generalized It is also called carob tree and it is obtained from the pain, stiffness, and tenderness in at least 11 of 18 spe- fruit of the CS tree. CS flour is rich in polyphenols cific points1. In addition, FM is associated with a range and it acts as an antioxidant in the body25,26. Given its of symptoms, such as muscular stiffness, depression, low prize, CS can be considered a “low cost” source non-refreshing sleep, and cognitive impairments2,3. In of antioxidants. In mice, antidepressant effects were European population, the estimated prevalence of FM also reported in previous studies27. However, to our is around 3% to 5% of the general population4. knowledge, those results have not been studied in hu- Differences in physical fitness between FM and man samples. healthy women were compared in previous studies. Recent studies hypothesized that oxidative stress FM patients showed worse results in upper and lower may have a relevant role in the pathophysiology of limb strength, balance, flexibility, and aerobic endu- FM28. This, along with the effects of oxidative stress in rance5,6. FM is also associated with high prevalence physical condition22, suggests that antioxidant sources of overweight and obesity. In this regard, a recent could improve physical fitness in FM patients. study reported that approximately 72% of women Given the potential effects of GL and CS, not only with fibromyalgia are overweight or obese7. This an- as antioxidant sources (especially the GL, which may thropometric difference could be given because FM have other benefits cited above), the aim of the pre- patients are more prone to physical inactivity than sent study was to evaluate the effects of GL and CS healthy people8. This sedentary tendency may be in- on physical fitness in patients suffering from FM. A creased by FM symptoms like pain, fatigue, stiffness secondary objective was to evaluate the safety of GL or depression, while at the same time some of these and CS treatments. symptoms could be worsened by physical inactivity, i.e. poor physical conditioning or depression9. All of this can lead a reduction in health-related quality of Methods life (HRQoL)10. Recommended therapies in FM include pharmaco- Participants logical and non-pharmacological therapies. Among non-pharmacological treatments, physical therapies All participants were recruited from three FM as- were reported to be effective at increasing well-being sociations. The following inclusion criteria were set: and physical function11. Natural and nutritional the- 1) be diagnosed with FM by a rheumatologist; 2) be rapies are currently being studied in this syndrome able to communicate effectively with study staff; 3) because these could be helpful at improving different be older than 18 years old; 4) Give written-informed symptoms12. consent. On the other hand, exclusion criteria were Among those alternative therapies, Ganoderma lu- the following: 1) be pregnant; 2) change their daily cidum (GL), also known as reishi or linghzi, has been activity during the 6 weeks of treatment; 3) be taking widely used and studied in different populations. It is immunosuppressive; 4) be suffering from diabetes; 5) a type of mushroom that has demonstrated his efficacy be participating in other investigations; 6) be taking C at increasing vital energy, stimulating the immune sys- vitamin supplementation; 7) be taking anticoagulants, tem, and promoting health13. Previous research investi- and 8) have taken GL and/or CS as a treatment be- gated its effect as a treatment of different diseases, like fore. Additionally, an algometer (PainTest™ FPX 25 cancer14, diabetes15, Human Immuno Virus16, or hepa- Algometer. Wagner Instruments, Greenwich, USA) titis17. Different properties and effects were also repor- was used in order to check FM diagnosis. Participants ted, such as anti-inflammatory18, anti-oxidant15, antivi- without acute painful response in at least 11 of 18 spe- ral19, neuroprotective20, and hypotensive21. Effects of cified tender points stimulated with a pressure of 4 kg/ GL on physical conditioning still remain unknown in cm2 were excluded. humans. To our knowledge, only one investigation22 Figure 1 shows the flow diagram of participants. A assessed the effects of GL on physical fitness, and total of 70 subjects were initially recruited. Sixty-se- they concluded that the antioxidant effect of GL could ven of them were women and 3 were men. Five par- protect endurance athletes from overtraining. Effec- ticipants were excluded because they did not meet the tiveness in increasing antioxidant enzymes activities inclusion criteria and 1 declined to participate. A total was also investigated in mice23. This study shown the of 64 women took part in the study. All of them signed evidence that GL possessed protective effects against the informed consent in accordance with the updated a strenuous exercise that could induce oxidative stress. Declaration of Helsinki. Furthermore, relevant effects on physical condition This study was approved by the Biomedical Ethics and fatigue were reported in breast cancer patients24. Committee of the University. The trial was registered However, the mechanism under these improvements in the Australian New Zealand
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