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Ergosterol Purified from Medicinal Mushroom Amauroderma Rude Inhibits Cancer Growth in Vitro and in Vivo by Up-Regulating Multiple Tumor Suppressors
www.impactjournals.com/oncotarget/ Oncotarget, Vol. 6, No. 19 Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors Xiangmin Li1,2,3,4,*, Qingping Wu2,*, Yizhen Xie2, Yinrun Ding2, William W. Du3,4, Mouna Sdiri3,4, Burton B. Yang3,4 1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, PR China 2State Key Laboratory of Applied Microbiology Southern China (The Ministry-Province Joint Development), Guangdong Institute of Microbiology, Guangzhou, 510070, PR China 3Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, M4N3M5, Canada 4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M4N3M5, Canada *These authors have contributed equally to this work Correspondence to: Yizhen Xie, e-mail: [email protected] Burton B. Yang, e-mail: [email protected] Keywords: herbal medicine, medicinal mushroom, Foxo3a, Bim, Fas Received: April 08, 2015 Accepted: May 13, 2015 Published: May 27, 2015 ABSTRACT We have previously screened thirteen medicinal mushrooms for their potential anti-cancer activities in eleven different cell lines and found that the extract of Amauroderma rude exerted the highest capacity in inducing cancer cell death. The current study aimed to purify molecules mediating the anti-cancer cell activity. The extract of Amauroderma rude was subject to fractionation, silica gel chromatography, and HPLC. We purified a compound and identified it as ergosterol by EI-MS and NMR, which was expressed at the highest level in Amauroderma rude compared with other medicinal mushrooms tested. We found that ergosterol induced cancer cell death, which was time and concentration dependent. -
A New Pericarbonyl Lignan from Amauroderma Rude
ORIGINAL ARTICLE Rec. Nat. Prod. 13:4 (2019) 296-300 A New Pericarbonyl Lignan from Amauroderma rude Miao Dong 1, Zuhong Ma 2, Qiaofen Yang 2, Qiuyue Hu 2, Yanqing Ye 2,* and Min Zhou 1,* 1Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China 2 School of Chemistry and Environment, Yunnan Minzu University, Kunming 650031, P.R. China (Received October 24, 2018; Revised November 29, 2018; Accepted November 30, 2018) Abstract: A new pericarbonyl lignan (1), named amaurolignan A was isolated from an ethanol extract of the fruiting bodies in Amauroderma rude of family Ganodermataceae, together with two known lignans, 4-methoxymatairesinol 4′-β-D-glucoside (2) and lappaol F (3). The structures of compounds (1-3) were elucidated using NMR and MS spectroscopic methods. Keywords: Pericarbonyl lignan; amaurolignan A; Amauroderma rude. © 2019 ACG Publications. All rights reserved. 1. Introduction “Lingzhi” is a mushroom that has been renowned in China for more than 2000 years because of its claimed medicinal properties and symbolic fortune, which translates as ‘Ganodermataceae’ in a broad sense, and in a narrow sense it represents the highly prized medicinal Ganoderma species distributed in East Asia [1]. Its medicinal properties include anti-aging, lowering blood pressure, improving immunity, and preventing and treating various cancers, chronic bronchitis, gastric ulcers, hepatitis, neurasthenia and thrombosis [2-4]. The medicinal effects of many mushrooms such as Ganoderma lucidum, Lentinula edodes, Agaricus blazei, Antrodia camphorate and Grifola frondosaI come from their metabolites including polysaccharides, triterpenes, lucidenic acids, adenosine, ergosterol, glucosamine and cerebrosides [5-8]. -
Cultural Characterization and Chlamydospore Function of the Ganodermataceae Present in the Eastern United States
Mycologia ISSN: 0027-5514 (Print) 1557-2536 (Online) Journal homepage: https://www.tandfonline.com/loi/umyc20 Cultural characterization and chlamydospore function of the Ganodermataceae present in the eastern United States Andrew L. Loyd, Eric R. Linder, Matthew E. Smith, Robert A. Blanchette & Jason A. Smith To cite this article: Andrew L. Loyd, Eric R. Linder, Matthew E. Smith, Robert A. Blanchette & Jason A. Smith (2019): Cultural characterization and chlamydospore function of the Ganodermataceae present in the eastern United States, Mycologia To link to this article: https://doi.org/10.1080/00275514.2018.1543509 View supplementary material Published online: 24 Jan 2019. Submit your article to this journal View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=umyc20 MYCOLOGIA https://doi.org/10.1080/00275514.2018.1543509 Cultural characterization and chlamydospore function of the Ganodermataceae present in the eastern United States Andrew L. Loyd a, Eric R. Lindera, Matthew E. Smith b, Robert A. Blanchettec, and Jason A. Smitha aSchool of Forest Resources and Conservation, University of Florida, Gainesville, Florida 32611; bDepartment of Plant Pathology, University of Florida, Gainesville, Florida 32611; cDepartment of Plant Pathology, University of Minnesota, St. Paul, Minnesota 55108 ABSTRACT ARTICLE HISTORY The cultural characteristics of fungi can provide useful information for studying the biology and Received 7 Feburary 2018 ecology of a group of closely related species, but these features are often overlooked in the order Accepted 30 October 2018 Polyporales. Optimal temperature and growth rate data can also be of utility for strain selection of KEYWORDS cultivated fungi such as reishi (i.e., laccate Ganoderma species) and potential novel management Chlamydospores; tactics (e.g., solarization) for butt rot diseases caused by Ganoderma species. -
A New Record of Ganoderma Tropicum (Basidiomycota, Polyporales) for Thailand and First Assessment of Optimum Conditions for Mycelia Production
A peer-reviewed open-access journal MycoKeys 51:A new65–83 record (2019) of Ganoderma tropicum (Basidiomycota, Polyporales) for Thailand... 65 doi: 10.3897/mycokeys.51.33513 RESEARCH ARTICLE MycoKeys http://mycokeys.pensoft.net Launched to accelerate biodiversity research A new record of Ganoderma tropicum (Basidiomycota, Polyporales) for Thailand and first assessment of optimum conditions for mycelia production Thatsanee Luangharn1,2,3,4, Samantha C. Karunarathna1,3,4, Peter E. Mortimer1,4, Kevin D. Hyde3,5, Naritsada Thongklang5, Jianchu Xu1,3,4 1 Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China 2 University of Chinese Academy of Sciences, Bei- jing 100049, China 3 East and Central Asia Regional Office, World Agroforestry Centre (ICRAF), Kunming 650201, Yunnan, China 4 Centre for Mountain Ecosystem Studies (CMES), Kunming Institute of Botany, Kunming 650201, Yunnan, China 5 Center of Excellence in Fungal Research, Mae Fah Luang University, Chiang Rai 57100, Thailand Corresponding author: Jianchu Xu ([email protected]); Peter E. Mortimer ([email protected]) Academic editor: María P. Martín | Received 30 January 2019 | Accepted 12 March 2019 | Published 7 May 2019 Citation: Luangharn T, Karunarathna SC, Mortimer PE, Hyde KD, Thongklang N, Xu J (2019) A new record of Ganoderma tropicum (Basidiomycota, Polyporales) for Thailand and first assessment of optimum conditions for mycelia production. MycoKeys 51: 65–83. https://doi.org/10.3897/mycokeys.51.33513 Abstract In this study a new record of Ganoderma tropicum is described as from Chiang Rai Province, Thailand. The fruiting body was collected on the base of a livingDipterocarpus tree. -
Ganoderma: Progresos En Investigación, Manejo Y Retos a Futuro* Ganoderma: Research Advances, Management and Future Challenges
sesión 1. plagas y enfermedades Ganoderma: progresos en investigación, manejo y retos a futuro* Ganoderma: Research Advances, Management and Future Challenges autores: Shamala Sundram, Idris Abu Seman, Nur Diyana Roslan, Lee Pei Lee Angel, Intan Nur Ainni Mohamed Azni, Salwa Abdullah Sirajuddin. citación: Sundram, S., Seman, I. A., Roslan, N. D., Angel, L. P. L., Mohamed- Azni, I. N. A., & Sirajuddin, S. A. (2019). Ganoderma: progresos en investigación, manejo y retos a futuro. Palmas, 40 (Especial Tomo I), 57-69. palabras clave: palma de aceite, Ganoderma, Pudrición basal del estípite, manejo, retos. keywords: Oil palm, Ganoderma, basal stem rot, control, challenges. *Artículo original recibido en inglés y traducido por Carlos Arenas París. Shamala Sundram Junta de Aceite de Palma de Malasia Malaysian Palm Oil Board (MPOB) Resumen La palma de aceite, el cultivo que se extiende por la región del cinturón ecuatorial, no está exenta de pestes y enfermedades. Este cultivo es altamente susceptible a una serie de enfermedades limitadas a la región donde se planta. La Pudrición basal del estípite es causada por Ganoderma spp., la amenaza número uno en la región del Sudeste Asiático. Históricamente, era percibida como una enfermedad senescente, pero pronto se descubrió que su prevalencia no tiene correlación con la edad de la palma. Además de los factores predisponentes que incluyen parámetros bióticos y abióticos, se planteó la hipótesis de que los materiales de siembra anteriores, el tipo de suelo, el estado de los nutrientes y las técnicas de replantación contribuían a su propagación. De todos estos factores, la técnica de replantación juega un papel fundamental para controlarla, pero no es suficiente. -
Traditional Uses, Chemical Components and Pharmacological Activities of the Genus Ganoderma Cite This: RSC Adv., 2020, 10,42084 P
RSC Advances View Article Online REVIEW View Journal | View Issue Traditional uses, chemical components and pharmacological activities of the genus Ganoderma Cite this: RSC Adv., 2020, 10,42084 P. Karst.: a review† Li Wang,a Jie-qing Li,a Ji Zhang,b Zhi-min Li,b Hong-gao Liu*a and Yuan-zhong Wang *b In recent years, some natural products isolated from the fungi of the genus Ganoderma have been found to have anti-tumor, liver protection, anti-inflammatory, immune regulation, anti-oxidation, anti-viral, anti- hyperglycemic and anti-hyperlipidemic effects. This review summarizes the research progress of some promising natural products and their pharmacological activities. The triterpenoids, meroterpenoids, sesquiterpenoids, steroids, alkaloids and polysaccharides isolated from Ganoderma lucidum and other species of Ganoderma were reviewed, including their corresponding chemical structures and biological activities. In particular, the triterpenes, polysaccharides and meroterpenoids of Ganoderma show a wide Creative Commons Attribution-NonCommercial 3.0 Unported Licence. range of biological activities. Among them, the hydroxyl groups on the C-3, C-24 and C-25 positions of the lanostane triterpenes compound were the necessary active groups for the anti-HIV-1 virus. Previous study showed that lanostane triterpenes can inhibit human immunodeficiency virus-1 protease with an IC50 value of 20–40 mM, which has potential anti-HIV-1 activity. Polysaccharides can promote the Received 24th August 2020 production of TNF a and IFN-g by macrophages and spleen cells in mice, and further inhibit or kill tumor Accepted 10th November 2020 cells. Some meroterpenoids contain oxygen-containing heterocycles, and they have significant DOI: 10.1039/d0ra07219b antioxidant activity. -
0026432-27012017164624.Pdf
Cronfa - Swansea University Open Access Repository _____________________________________________________________ This is an author produced version of a paper published in : Bioresources and Bioprocessing Cronfa URL for this paper: http://cronfa.swan.ac.uk/Record/cronfa26432 _____________________________________________________________ Paper: Plácido, J., Chanagá, X., Ortiz-Monsalve, S., Yepes, M. & Mora, A. (2016). Degradation and detoxification of synthetic dyes and textile industry effluents by newly isolated Leptosphaerulina sp. from Colombia. Bioresources and Bioprocessing, 3(1) http://dx.doi.org/10.1186/s40643-016-0084-x _____________________________________________________________ This article is brought to you by Swansea University. Any person downloading material is agreeing to abide by the terms of the repository licence. Authors are personally responsible for adhering to publisher restrictions or conditions. When uploading content they are required to comply with their publisher agreement and the SHERPA RoMEO database to judge whether or not it is copyright safe to add this version of the paper to this repository. http://www.swansea.ac.uk/iss/researchsupport/cronfa-support/ Plácido et al. Bioresour. Bioprocess. (2016) 3:6 DOI 10.1186/s40643-016-0084-x RESEARCH Open Access Degradation and detoxification of synthetic dyes and textile industry effluents by newly isolated Leptosphaerulina sp. from Colombia Jersson Plácido*, Xiomara Chanagá, Santiago Ortiz‑Monsalve, María Yepes and Amanda Mora Abstract Background: Wastewaters from the textile industry are an environmental problem for the well-known Colombian textile industry. Ligninolytic fungi and their enzymes are an option for the treatment of these wastewaters; how‑ ever, the Colombian biodiversity has not been deeply evaluated for fungal strains with ligninolytic activities. In this research, 92 Colombian fungal isolates were collected from four locations around the Aburrá valley, Antioquia, Colom‑ bia. -
Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance
molecules Review Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance Katarzyna Wi ´nska* , Wanda M ˛aczka*, Klaudia Gabryelska and Małgorzata Grabarczyk * Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland; [email protected] * Correspondence: [email protected] (K.W.); [email protected] (W.M.); [email protected] (M.G.); Tel.: +48-71-320-5213 (K.W. & W.M.) Academic Editor: Isabel C.F.R. Ferreira Received: 30 September 2019; Accepted: 8 November 2019; Published: 11 November 2019 Abstract: Pharmacotherapy using natural substances can be currently regarded as a very promising future alternative to conventional therapy of diabetes mellitus, especially in the case of chronic disease when the body is no longer able to produce adequate insulin or when it cannot use the produced insulin effectively. This minireview summarizes the perspectives, recent advances, and major challenges of medicinal mushrooms from Ganoderma genus with reference to their antidiabetic activity. The most active ingredients of those mushrooms are polysaccharides and triterpenoids. We hope this review can offer some theoretical basis and inspiration for the mechanism study of the bioactivity of those compounds. Keywords: Ganoderma; antidiabetic; polysaccharides; triterpenoids; meroterpenoids 1. Introduction Diabetes is a metabolic disorder caused by a lack of insulin and insulin dysfunction characterized by hyperglycemia. Nowadays, diabetes has become a serious problem. This disease is no longer considered congenital and rare. It affects more and more people and is the subject of many discussions. The International Diabetes Federation in the eighth edition of Global Diabetes Map published data according to which in 2017 the number of adults of diabetes worldwide patients (20–79 years) reached 415 million. -
Ganodermataceae
GANODERMATACEAE Medium sized to very large; on wood (living or dead); primarily saprophytic 5 Genera; 81 Species Basidioma perennial or annual; bracket-like or sometimes stipitate, frequently thickened. Pileus knob-, shelf-, or bracket-like; upper surface hard, crusty, wavy, sometimes varnished, sometimes dusted with spores, zoned, ridged, or grooved, coriaceous; context thick, punky, corky, unreactive with KOH. Hymenium tubulate; pores minute to small, sometimes barely visible; tubes often stratified. Stipe absent or present, rudimentary or well developed, often as an extension of the pileus; veil absent; volva absent. Spore print brown to reddish brown, frequently difficult to obtain; spores broadly elliptical, ornamented, thick or double-walled. GANODERMATACEAE is a widespread family of wood decay organisms most abundant in the tropics. As a lignicolous organism, members of the family produce a “white rot” in the substrate upon which it is growing. Only Ganoderama has a confirmed presence in northern Utah. GANODERMA Medium sized to very large; on wood Basidioma perennial or annual, solitary or in small groups. Pileus knob-, shelf-, or bracket-like, sometimes thick, tough, hard, or woody when dry; upper surface hard, crusty, waxy sometimes appearing varnished or dusted with spores, color variable; context brown to cinnamon-, ochraceous-brown or dark brown. Hymenium tubulate; tube layers stratified when perennial, rarely with more than two layers if annual; pores minute to barely visible, whitish to yellowish-white, bruising brown when fresh. Stipe absent or rudimentary as an extension of the pileus; veil and volva absent. Spore print brown, when obtainable, often found as a deposit on the upper surface of the basidioma; spores elliptical, ornamented often minutely so, thick or double-walled. -
II. the Genus Amauroderma Murrill
ZOBODAT - www.zobodat.at Zoologisch-Botanische Datenbank/Zoological-Botanical Database Digitale Literatur/Digital Literature Zeitschrift/Journal: Sydowia Jahr/Year: 1968/1969 Band/Volume: 22 Autor(en)/Author(s): Otieno Nickson E. Artikel/Article: Polyporaceae of Eastern Africa: II. The genus Amauroderma Murrill. 173-178 ©Verlag Ferdinand Berger & Söhne Ges.m.b.H., Horn, Austria, download unter www.biologiezentrum.at Polyporaceae of Eastern Africa: II. The genus Amauroderma Murrill By N. C. O tie no, Bot. Dept. University College, Nairobi, Kenya. With plates VII—X. Introduction: This is the third paper to report results of work which has been carried out in the Department of Botany, University College Nairobi, on Polyporaceae of Eastern Africa. The first paper (Otieno: 1966) was concerned with the genus Favolus Fr., while the second paper (In Press) has produced a check-list of Polyporaceae which have been col- lected from our area. The genus Amauroderma appears to be fairly widespread in Eastern Africa as the present paper shows. It is inter- esting, however, to note that, of the eleven species herein described, seven are from Uganda, three from Kenya and one from Rhodesia. The twelfth species from Zambia has not been seen by the writer and it is only mentioned in passing. Recently, one species has been collected by the writer from Tanzania near Dar-es-Salaam, another from the coast of Kenya near Mombasa. These will be reported separately in a sub- sequent paper. It is evident, therefore, that the discontinuity in the distribution of Amauroderma in eastern Africa could be attributed to scanty col- lecting that has been done; and it is our hope that this preliminary paper will stimulate further work on Amauroderma so that our knowl- edge of the genus becomes more thorough than it is at present. -
National Botanic Garden of Wales Ecology Report, 2016
Regency Landscape Restoration Project ECOLOGICAL SURVEYS and ASSESSMENT VOLUME 1: REPORT Revision of 18th April 2016 Rob Colley Jacqueline Hartley Bruce Langridge Alan Orange Barry Stewart Kathleen Pryce Richard Pryce Pryce Consultant Ecologists Trevethin, School Road, Pwll, LLANELLI, Carmarthenshire, SA15 4AL, UK. Voicemail: 01554 775847 Mobile: 07900 241371 Email: [email protected] National Botanic Garden of Wales REVISION of 18th April 2016 Regency Landscape Restoration Project: Ecological Assessment REVISION RECORD DATE Phase 1 field survey completed 11/10/15 RDP Phase 1 TNs completed & checked 30/10/15 RDP First Working Draft issued to client 9/11/15 RDP Second Working Draft issued to client (interim bat section added) 19/11/15 RDP Third Working Draft issued to client (draft texts for dormouse, badger 19/1/16 RDP and updated bat sections added) Revised and augmented badger section added. 11/2/16 JLH & RDP Revised section only, issued to client. Fungi section added from Bruce Langridge 31/3/16 RDP Otter & bat updates added 11/4/16 RDP Bryophyte, winter birds & invertebrate updates added 15/4/16 RDP All figures finalized 15/4/16 SR Text of report proof read 16-17/4/16 KAP & RDP Add revised bird section & invertebrate appendices 17/4/16 RDP Final Report, appendices and figures issued to client 18/4/16 RDP ________________________________________________________________________________________________ Pryce Consultant Ecologists Trevethin, School Road, Pwll, Llanelli, Carmarthenshire, SA15 4AL. Voicemail: 01554 775847 Mobile: 07900 241371 Email: [email protected] PAGE 2 National Botanic Garden of Wales REVISION of 18th April 2016 Regency Landscape Restoration Project: Ecological Assessment SUMMARY OF SIGNIFICANT ECOLOGICAL ISSUES 1. -
Molecular Phylogeny of Polyporales from Bafut Forest, Cameroon and Their Importance to Rural Communities
Journal of Biology and Life Science ISSN 2157-6076 2019, Vol. 10, No. 2 Molecular Phylogeny of Polyporales from Bafut Forest, Cameroon and Their Importance to Rural Communities Tonjock Rosemary Kinge (Corresponding author) Department of Biological Sciences, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, North West Region, Cameroon Email: [email protected] Azinue Clementine Lem Department of Biological Sciences, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, North West Region, Cameroon Email: [email protected] Seino Richard Akwanjoh Department of Biological Sciences, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, North West Region, Cameroon Email: [email protected] Received: January 9, 2019 Accepted: January 26, 2019 doi:10.5296/jbls.v10i2.14339 URL: https://doi.org/10.5296/jbls.v10i2.14339 Abstract The polyporales are a large order of pore fungi within the Basidiomycota (Kingdom Fungi). They are mostly found on decay wood with some edible and medicinal species and others causing diseases of trees. In Cameroon, the knowledge on the phylogeny of polyporales is limited, their historical uses as food, medicine, source of income and the sociological impacts are apparently threatened due to slow ethnomycology research drive. The aim of this study was to identify and determine the phylogenetic relationship of polyporales in the Bafut forest and document its uses to the local communities. DNA was extracted using CTAB method and amplified using primers ITS 1 and ITS4. Their identities were determined in GeneBank using BLAST and a phylogenetic analysis was done using MEGA version 7.