DOCSLIB.ORG

Otoacoustic Emissions: an 323), 923 Robie Street, Halifax, Nova Scotia, B3H 3C3, Canada, Tel: 902-420-5846, Fax: 902-496-8287; Email

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Otoacoustic Emissions: an 323), 923 Robie Street, Halifax, Nova Scotia, B3H 3C3, Canada, Tel: 902-420-5846, Fax: 902-496-8287; Email Central Annals of Otolaryngology and Rhinology Short Communication *Corresponding author Andrea L.O. Hebb, Department of Psychology, Saint Mary’s University, McNally Building South Wing (MS Otoacoustic Emissions: An 323), 923 Robie Street, Halifax, Nova Scotia, B3H 3C3, Canada, Tel: 902-420-5846, Fax: 902-496-8287; Email: Invaluable Screen of Neonatal Submitted: 13 November 2018 Accepted: 04 December 2018 Hearing Published: 05 December 2018 ISSN: 2379-948X 1 1,2 Scott A. Davenport , and Andrea L.O. Hebb * Copyright 1Department of Psychology, Saint Mary’s University, Canada © 2018 Hebb et al. 2Divisions of Neurosurgery, Otolaryngology─Head & Neck Surgery and Department of Radiation Oncology, Dalhousie University, Canada OPEN ACCESS Keywords Abstract • Otoacoustic emissions Otoacoustic emissions (OAEs) including evoked otoacoustic emissions test (EOAE), • Hearing automated auditory brainstem response (a-ABR), transitory evoked otoacoustic • Hearing loss emissions (TEOAEs) and brainstem auditory evoked potential (BAEP) are invaluable in assessing hearing in the newborn and non-verbal children and young adults. The following article briefly outlines the implementation of OAEs in clinical settings and highlights future research potential. INTRODUCTION delay, cognitive motor or visual disabilities brainstem auditory evoked potential (BAEP) may be recommended [6]. Comparing Otoacoustic emissions (OAEs) are low-level signals emitted the BAEP, a-ABR, and auditory transitory evoked otoacoustic inside the cochlea and recorded in the auditory canal. OAEs were emissions (a-TEOAE); measuring the variables of sensitivity, theorized over 60 years ago by the biophysicist Thomas Gold [1]; although his proposal of an active cochlear process was not ratio demonstrated that overall the BAEP was the better test. specificity, positive and negative predictive value and odds recorded and - tentatively - explained by Kemp who used a low- widely accepted until the 1970s. The first human OAEs were to be predictions, and a much lower false positive rate than the EOAE level click as the stimulus and recorded the cochlear echoes [2, 3]. andThe a-ABRBAEP had[6]. higher sensitivity and specificity, accuracy in its Since Kemp’s observation and subsequent experiment(s) OAEs have been studied extensively and implemented as a routine OAE use neonatal screening test for hearing loss. In addition, neonatal hyperbilirubinemia, familial auditory neuropathy, end-stage loss occurring in 1-3 infants per 1000 in Canada [9]. Otoacoustic emissionsHearing (OAEs) loss is are a common often used deficit, in combination with severe with to profound detailed the conditions which may precipitate hearing loss in children medical histories to reveal the etiology of hearing loss in infants andrenal in disease, which OAEsand neurofibromatosis have been utilized type[3-7]. II The(NF2) purpose are some of the of ensuing discussion is to demonstrate the effectiveness of OAEs typically normal in familial auditory neuropathy with absence (and the various tests inspired by the mechanism) as a versatile of[7, auditory10]. For brainstemexample, responsesotoacoustic [7]. emission The OAE recordings is a normal are component of screening and experimentation. physiologic response generated by the outer hair cells of the Comparison of tests cochlea. A hearing sensitivity of 30 dB HL is indicated by a pass on an OAE test [11]. Hospital based universal neonatal hearing screening programs are at present widely used; the most effective ones Hyperbilirubinemia are evoked otoacoustic emissions test (EOAE), followed by an Hyperbilirubinemia has devastating effects on the auditory automated auditory brainstem response (a-ABR) for all infants system. Even short term increases in bilirubin levels can induce temporary or permanent changes in evoked potentials [4]. for detecting hearing loss in high-risk neonates has not been fully Baradaranfar et al. conducted a study on newborn babies with elucidated.failing the EOAE Examinations [3, 6, 8]. Thehave accuracy often been and hampered efficacy of by these excessive tests environmental electrical “noise”, electro-myogenic interference ABR, 9 with abnormal ABRs, 5 had no ABR waves at all and 4 (from behavioural distress), and cochlear immaturity [6, hadjaundice increased [4]. I-IIIThirty-five and III-V infants intervals were and tested, latency 26 inhad all normalwaves. 8]. Subsequently, visual reinforcement audiometry (VRA) is Twenty-six infants had normal hearing, 4 mild to moderate typically recommended, however, in the case of developmental Cite this article: Davenport SA, Hebb ALO (2018) Otoacoustic Emissions: An Invaluable Screen of Neonatal Hearing. Ann Otolaryngol Rhinol 5(5): 1222. Hebb et al. (2018) Email: [email protected] Central hearing loss, and 5 suffered from severe to profound hearing loss. screening and experimentalresearch on mechanisms underlying OAE could be recorded in 1 infant with mild to moderate hearing hearing loss. loss and 4 with severe to profound hearing loss. Overall, 26 had normal tests and in 5 infants, abnormal results were localized to REFERENCES the retro-cochlear region indicative of auditory neuropathy [4]. 1. Gold T, Pumphrey RJ. Hearing. I. The cochlea as a frequency analyzer. Proc R Soc Lond B Biol Sci. 1948; 135: 462–491. Kidney Disease 2. Kemp DT. Stimulated acoustic emissions from within the human Abnormalities in auditory systems are frequent in children auditory system. JASA. 1978; 64:1386–91. with end-stage renal disease (ESRD); there is not yet any 3. Pigasse G. Deriving cochlear delays in humans using otoacoustic consensus for the effect of renal failure and hemodialysis on emissions and auditory evoked potentials. Technical University of auditory complications [5]. In a study conducted by Naderpour Denmark. 2008; 1-177. et al.children were tested in three groups: 25 ESRD patients 4. Braadaranfar, M.H., Atighechi, S., Dadgarnia, M.H., Jafari, R., Karimi, G., undergoing hemodialysis, 25 non-dialytic patients with chronic Mollasadeghi, A., Eslami, Z., & Baradarnfar A. (2009). Hearing status in renal failure, and 25 age and sex-matched control subjects [5]. neonatal hyperbilirubinemia by auditory brain stem evoked response ABR testing was abnormal in 11 dialysis patients with normal and transient evoked otoacoustic emission. Acta Medica Iranica. 2009; results in all 25 non-dialytic patients with chronic renal failure 49: 109-112. cases and controls. OAE testing was abnormal in all dialytic 5. patients with abnormal ABR testing. Sensorineural hearing Movaghar, M.H. Auditory brain stem response and otoacoustic loss was rare among non-dialytic patients with chronic renal emissionNaderpour, results M., inMortazavi, children with F., end-stageJabbari-Moghaddam, renal disease. Y., International & Sharifi- failure but very common in ESRD children undergoing long-term Journal of Pediatric Otorhinolaryngology. 2011; 75, 704-707. dialysis [5]. 6. Suppiej A, Rizzardi E, Zanardo V, Franzoi M, Ermani M, Orzan E. Reliability of hearing screening in high-risk neonates: Comparative Neurofibromatosis type II (NF2) study of otoacoustic emission, automated and conventional auditory Children with NF2 have an increased risk for hearing loss. brainstem response. Clinical Neurophysiology. 2007; 118, 869-876. Otoacoustic emissions are forms of energy (sound) generated 7. Wang, Q., Gu, R., Han, D., & Yang, W. Familial auditory neuropathy. The by the outer hair cells of the cochlea and can be used to assess Laryngoscope. 2013; 113, 1623-1629. cochlear hearing loss. Evoked otoacoustic emissions (EOAEs) 8. Kanji A, Khoza-Shangase K, Moroe N. Newborn hearing screening pro- have been used to assess outer hair cell and cochlear hearing tocols and their outcomes: A systematic review. Int J Pediatr Otorhi- nolaryngol. 2018; 115:104-109. 15]. Although typically used in infants, EOAEs have been used loss function in non-verbal neurofibromatosis NF2 patients [12- 9. Eskander A, Papsin BC. Screening infants for hearing impairment in to assess cochlear function in adult non-verbal NF2 patients Canada. CMAJ. 2014; 186: 1048-1049. [unpublished observation, 13]. 10. Chen MM, Oghalai JS. Diagnosis and Management of Congenital Canadian Research Sensorineural Hearing Loss. Curr Treat Options Pediatr. 2016; 2: 256- 265. Robert V. Harrison (2018) has repeatedly demonstrated OAE measurement as an important clinical and research tool. In 11. Jerry J, Oghalai JS. Towards an etiologic diagnosis: assessing the patient with hearing loss. Adv Otorhinolaryngol. 2011; 70: 28-36. terms of newborn hearing screening, OAEs testing is used even more than the standard behavioural audiogram [16]. OAEs can 12. Telischi FF, Roth J, Stagner BB, Lonsbury-Martin BL, Balkany TJ. be used to test outer hair cell integrity [17]. While ipsilateral and Patterns of evoked otoacoustic emissions associated with acoustic contralateral OAE suppression can be used to test some aspects neuromas. Laryngoscope.1995; 105: 675-682. of auditory brainstem functioning; the full potential of OAE in 13. Maritime Lateral Skullbase Clinic (2018). Halifax, NS. Canada. clinical testing has not yet been reached [16]. 14. Gouveris HT, Victor A, Mann WJ. Cochlear origin of early hearing loss CONCLUSION in vestibular schwannoma. Laryngoscope. 2007; 117: 680–683. 15. Prasher DK, Tun T, Brookes GB, Luxon LM. Mechanisms of hearing OAEs and other objective tests (BAEP, aABR)are invaluable loss in acoustic neuroma: an otoacoustic emission study. Acta non-invasive screening tests that are applicable to many
Load more

Recommended publications
  • A Guide to Otoacoustic Emissions Contents
    Science made smarter A Guide to Otoacoustic Emissions Contents What are OAEs? ................................................................................ 4 Stimulus tolerance............................................................................................................................................................22 Filtering (TEOAE) ................................................................................................................................................................22 What are Otoacoustic Emissions (OAEs)? ........................................................... 4 Noise rejection level ......................................................................................................................................................23 Types of OAEs ................................................................................................................ 5 Measuring at ambient or tympanic peak pressure (pressurized OAE) ...........................................23 DPOAEs ............................................................................................................................. 6 OAE detection/stopping criteria ............................................................................................................................25 TEOAEs .............................................................................................................................. 7 Screening vs diagnostic OAE ........................................................8 Before and
    [Show full text]
  • A Rare Case of Hearing Impairment Due to Cerebello-Pontine Angle Lesion: Trigeminal Schwannoma
    J Int Adv Otol 2015; 11(2): 170-2 • DOI: 10.5152/iao.2015.252 Case Report A Rare Case of Hearing Impairment due to Cerebello-Pontine Angle Lesion: Trigeminal Schwannoma Purushothaman Ganesan, Priya Sankaran, Purushothaman Pavanjur Kothandaraman SRM Medical College Hospital and Research Centre, Otorhinolaryngology, Audiology and Speech Language Pathology, Chennai, Tamilnadu, India Schwannoma of the trigeminal nerve is a rare condition. Even rarer is hearing loss occurring as a result of this lesion. The aim of this study is to highlight this rare cause of hearing impairment. Here we report the clinical features and findings of the imaging and audiological investigations of a case of trigeminal schwannoma diagnosed at our institution. Our patient presented with headache, giddiness, tinnitus, left-sided facial weakness, left-sided hearing loss, right-sided hemiplegia, and unintelligible speech. Radiological studies revealed a large well-defined mass lesion in the left cerebellopontine angle with a significant mass effect on posterior fossa structures, suggestive of trigeminal nerve tumor. Audio-vestibular assess- ment was done with pure tone audiometry, impedance audiometry, otoacoustic emission, brainstem-evoked response audiometry, and electronys- tagmography, which pointed toward a retrocochlear pathology for hearing loss and imbalance. KEYWORDS: Cerebellopontine angle tumor, vestibulocochlear nerve bundle, trigeminal schwannoma, electronystagmography INTRODUCTION Schwannomas, which usually exhibit benign behavior, are tumors arising from Schwann cells in the axon myelin sheaths [1]. Schwan- noma of the trigeminal nerve comprises only 0.2% to 0.4% of all intracranial tumors and primarily arises in the Gasserian ganglion [2]. They are relatively rare and less common than vestibular schwannoma [3]. They account for 0.07%–0.36% of all intracranial tumors and 0.8%–8% of intracranial schwannomas [4, 5].
    [Show full text]
  • Benzodiazepines Alter Cochleo-Cochlear Loop in Humans
    Hearing Research 121 (1998) 71^76 Benzodiazepines alter cochleo-cochlear loop in humans N. Morand a, E. Veuillet a;*, M.C. Gagnieu b, P. Lemoine c, L. Collet a a Laboratoire `Neurosciences et Systeémes Sensoriels', 3 place d'Arsonval, Pavillon U, Hoêpital Edouard Herriot, 69003 Lyon, France b Laboratoire de Pharmacologie, Hoêpital Edouard Herriot, Lyon, France c Uniteè Clinique de Psychiatrie Biologique, Le Vinatier, Bron, France Received 26 November 1997; revised 26 March 1998; accepted 7 April 1998 Abstract By using otoacoustic emission, we looked for change in outer hair cell (OHC) motile activity and medial olivocochlear (MOC) system inhibition due to benzodiazepine administration, a drug that is known to produce a pharmacological effect by interacting with GABAergic inhibitory neurotransmission. No effect was observed on OHC motile activity, in contrast benzodiazepines decreased MOC system effectiveness suggesting the existence of GABAergic fibers projecting onto the MOC system. z 1998 Elsevier Science B.V. All rights reserved. Key words: Gamma-aminobutyric acid; Outer hair cell; Olivocochlear e¡erent system; Otoacoustic emission 1. Introduction OHCs, principally acetylcholine (Ach) and the inhibi- tory neurotransmitter Q-aminobutyric acid (GABA) (for The organ of Corti is innervated by the olivocochlear review see Eybalin, 1993). Concerning GABA, several e¡erent system (Rasmussen, 1946), in which two sub- studies seem to prove the presence of GABAergic syn- components have been clearly distinguished (Warr, apses in the cochlea. The presence of GABA and glu- 1992; Warr and Guinan, 1979). The lateral olivo- tamic acid decarboxylase in ¢bers and e¡erent endings cochlear (LOC) system originates from lateral superior synapsing onto OHC bodies has been revealed by im- olivary neurons making synaptic contact with the a¡er- munocytochemistry data (Fex and Altschuler, 1984; ent inner radial ¢bers of the inner hair cell system.
    [Show full text]
  • Evolution of Mammalian Sound Localization Circuits: a Developmental Perspective
    Progress in Neurobiology 141 (2016) 1–24 Contents lists available at ScienceDirect Progress in Neurobiology journal homepage: www.elsevier.com/locate/pneurobio Review article Evolution of mammalian sound localization circuits: A developmental perspective a,b, Hans Gerd Nothwang * a Neurogenetics group, Center of Excellence Hearing4All, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26111 Oldenburg, Germany b Research Center for Neurosensory Science, Carl von Ossietzky University Oldenburg, 26111 Oldenburg, Germany A R T I C L E I N F O A B S T R A C T Article history: Localization of sound sources is a central aspect of auditory processing. A unique feature of mammals is Received 29 May 2015 the smooth, tonotopically organized extension of the hearing range to high frequencies (HF) above Received in revised form 27 February 2016 10 kHz, which likely induced positive selection for novel mechanisms of sound localization. How this Accepted 27 February 2016 change in the auditory periphery is accompanied by changes in the central auditory system is unresolved. Available online 28 March 2016 + I will argue that the major VGlut2 excitatory projection neurons of sound localization circuits (dorsal cochlear nucleus (DCN), lateral and medial superior olive (LSO and MSO)) represent serial homologs with Keywords: modifications, thus being paramorphs. This assumption is based on common embryonic origin from an Brainstem + + Atoh1 /Wnt1 cell lineage in the rhombic lip of r5, same cell birth, a fusiform cell morphology, shared Evolution Homology genetic components such as Lhx2 and Lhx9 transcription factors, and similar projection patterns. Such a Innovation parsimonious evolutionary mechanism likely accelerated the emergence of neurons for sound Rhombomere localization in all three dimensions.
    [Show full text]
  • Characteristic of Stimulus Frequency Otoacoustic Emissions: Detection Rate, Musical Training Influence, and Gain Function
    brain sciences Article Characteristic of Stimulus Frequency Otoacoustic Emissions: Detection Rate, Musical Training Influence, and Gain Function Yao Wang, Zhihang Qi, Mengmeng Yu, Jinhai Wang and Ruijuan Chen * Department of Biomedical Engineering, School of Life Sciences, Tianjin Polytechnic University, Tianjin 300387, China; [email protected] (Y.W.); [email protected] (Z.Q.); [email protected] (M.Y.); [email protected] (J.W.) * Correspondence: [email protected]; Tel.: +86-022-83956678 Received: 14 August 2019; Accepted: 25 September 2019; Published: 26 September 2019 Abstract: Stimulus frequency otoacoustic emission (SFOAE) is an active acoustic signal emitted by the inner ear providing salient information about cochlear function and dysfunction. To provide a basis for laboratory investigation and clinical use, we investigated the characteristics of SFOAEs, including detection rate, musical training influence, and gain function. Sixty-five normal hearing subjects (15 musicians and 50 non-musicians, aged 16–45 years) were tested and analyzed at the probe level of 30 and 50 dB sound pressure levels (SPL) in the center frequency of 1 and 4 kHz in the study. The results indicate that (1) the detection rates of SFOAE are sensitive to the gender, (2) musicians reveal enhanced hearing capacity and SFOAE amplitudes compared with non-musicians, and (3) probe frequency has a significant effect on the compression threshold of SFOAE. Our findings highlight the importance of SFOAE in the clinical hearing screening and diagnosis and emphasize the use of musical training for the rehabilitation enhancement of the auditory periphery and hearing threshold. Keywords: auditory plasticity; detection rate; gain function; musical training; stimulus frequency otoacoustic emissions 1.
    [Show full text]
  • TAYADE, AMITKUMAR GULABRAO, Ph.D. Role of Medial Olivocochlear Neural Efferent Pathway in Perception of Tinnitus in Presence of Silence
    TAYADE, AMITKUMAR GULABRAO, Ph.D. Role of Medial Olivocochlear Neural Efferent Pathway in Perception of Tinnitus in Presence of Silence. (2018) Directed by Dr. Denise Tucker. 116 pp. Over 20 million Americans struggle with troublesome effects of tinnitus. Tinnitus has a negative impact on a patient’s overall health and social well-being. Tinnitus can be a disabling condition. People with tinnitus regularly experience distress, depression, anxiety, sleep disturbances, frustration, poor concentration and in some cases pain. Currently, there are no scientifically validated cures available for most types of tinnitus. In fact, there is a deficiency in neurophysiological knowledge related to tinnitus. There is an informational gap between silence, which exacerbate or trigger tinnitus and Medial Oliovocochlear (MOC) efferent neural pathway connection. The primary aim of this study is to investigate the MOC efferent neural pathway and neural connections responsible for tinnitus generation in silence/sensory deprivation. The primary hypothesis of this study is that silence/sensory deprivation makes MOC efferent neural pathway hyperactive which participate in tinnitus perception. Method: fifty-eight normal hearing individuals between age 18-35 years were recruited as participants in this study. By placing normal hearing participants in a sound booth for 10 minutes, silence/sensory deprivation was created. This offered assessment of MOC neural pathway in normal hearing participants in silence. Hyperactivity of MOC neural pathway was assessed by its more suppressive effect on stimulated otoacoustic emissions (TEOAEs) in silence. The required auditory measurements were recorded in the sound booth using recommended diagnostic protocols to ensure the effect of “only silence” on auditory structures.
    [Show full text]
  • From Otoacoustic Emission to Late Auditory Potentials P300: the Inhibitory Effect
    Research Paper Acta Neurobiol Exp 2012, 72: 296–308 From otoacoustic emission to late auditory potentials P300: the inhibitory effect Eliane Schochat*, Carla Gentile Matas, Alessandra Giannella Samelli, and Renata Mota Mamede Carvallo School of Medicine, Sao Paulo University, Sao Paulo, Brazil, *Email: [email protected] This study verifies the effects of contralateral noise on otoacoustic emissions and auditory evoked potentials. Short, middle and late auditory evoked potentials as well as otoacoustic emissions with and without white noise were assessed. Twenty-five subjects, normal-hearing, both genders, aged 18 to 30 years, were tested . In general, latencies of the various auditory potentials were increased at noise conditions, whereas amplitudes were diminished at noise conditions for short, middle and late latency responses combined in the same subject. The amplitude of otoacoustic emission decreased significantly in the condition with contralateral noise in comparison to the condition without noise. Our results indicate that most subjects presented different responses between conditions (with and without noise) in all tests, thereby suggesting that the efferent system was acting at both caudal and rostral portions of the auditory system. Key words: efferent pathways, contralateral suppression, otoacoustic emissions, auditory evoked potentials Abbreviations INTRODUCTION (EOAE) Evoked Otoacoustic Emission; The auditory system consists of ascending and (MOC) medial olivocochlear; descending (corticofugal) systems. The functional role (AC) auditory cortex; of the efferent auditory system in humans has not yet (MGB) medial geniculate body; been completely established and is difficult to demon- (IC) inferior colliculus; strate. Some methods employed in animals to study (CAPD) Central Auditory Processing Disorder; descending auditory pathways are often invasive and (ABR) Auditory Brainstem Response; damaging to the auditory pathways, and consequently, (MLR) -Middle Latency Response; they are not applicable in humans (Khalfa et al.
    [Show full text]
  • Otoacoustic Emissions Testing
    UnitedHealthcare of California (HMO) UnitedHealthcare Benefits Plan of California (EPO/POS) UnitedHealthcare of Oklahoma, Inc. UnitedHealthcare of Oregon, Inc. UnitedHealthcare Benefits of Texas, Inc. UnitedHealthcare of Washington, Inc. UnitedHealthcare® West Medical Management Guideline Otoacoustic Emissions Testing Guideline Number: MMG098.M Effective Date: July 1, 2021 Instructions for Use Table of Contents Page Related Medical Management Guideline Coverage Rationale ....................................................................... 1 • Preventive Care Services Definitions ...................................................................................... 2 Applicable Codes .......................................................................... 2 Description of Services ............................................................... 14 Clinical Evidence ......................................................................... 14 U.S. Food and Drug Administration ........................................... 24 References ................................................................................... 24 Guideline History/Revision Information ..................................... 27 Instructions for Use ..................................................................... 28 Coverage Rationale Neonatal hearing screening as a preventive service using otoacoustic emissions (OAEs) is proven and medically necessary for infants who are 90 days or younger. For hearing screening as a preventive service using OAEs for individuals
    [Show full text]
  • The Effects of Auditory Selective Attention on Contralateral
    Audiol. 2011;20(2):63-71. Research Article The effects of auditory selective attention on contralateral suppression of stimulus-frequency otoacoustic emissions Soheila Rostami1, Akram Pourbakht1, Mohammad Kamali2, Bahram Jalaee1 1- Department of Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Iran 2- Department of Rehabilitaion Management, Faculty of Rehabilitation, Tehran University of Medical Sciences, Iran on Tuesday, April 10, 2012 Received: 25 November 2010, accepted: 4 March 2011 Abstract Background and Aim: To date, the function of auditory efferent system remains unclear. There is evidence that medial olivocochlear bundle receives descending input from the cortex. In this study, the effect of auditory selective attention on stimulus-frequency otoacoustic emissions (SFOAE) was analyzed to investigate the modification of peripheral auditory system by auditory cortex activity in http://journals.tums.ac.ir/ frequency specific mode. Methods: Thirty-six normal hearing adult subjects with their age ranging from 18 to 30 years (mean age: 21.9 years) participated in this cross-sectional study. Contralateral suppression of stimulus- frequency otoacoustic emissions was recorded in the right ear at 2 KHz. In order to eliminate the auditory attention, subjects were instructed to read a text. Besides, in order to evaluate the effect of auditory attention on contralateral suppression, subjects were instructed to detect target tones in Downloaded from background noise at 1000, 2000, and 4000 KHz. Results: A significant increase at contralateral suppression of stimulus-frequency otoacoustic emissions was observed in auditory selective attention conditions (p>0.001). The largest magnitude of stimulus-frequency otoacoustic emissions suppression was seen at 2 KHz. Conclusion: The results of this study indicated that the activities of medial olivocochlear bundle enhanced by contralateral auditory selective attention increase the magnitude of stimulus-frequency otoacoustic emissions suppression.
    [Show full text]
  • Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation
    ORIGINAL RESEARCH published: 31 August 2016 doi: 10.3389/fncir.2016.00072 Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation Anna R. Chambers 1†‡, Juan J. Salazar 1,2†‡ and Daniel B. Polley 1,3* 1 Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, USA, 2 Department of Biology, École Normale Supérieure, PSL Research University, Paris, France, 3 Department of Otolaryngology, Harvard Medical School, Boston, MA, USA Neurons at higher stages of sensory processing can partially compensate for a sudden drop in peripheral input through a homeostatic plasticity process that increases the gain on weak afferent inputs. Even after a profound unilateral auditory neuropathy where >95% of afferent synapses between auditory nerve fibers and inner hair cells have been eliminated with ouabain, central gain can restore cortical processing and perceptual detection of basic sounds delivered to the denervated ear. In this model of profound auditory neuropathy, auditory cortex (ACtx) processing and perception Edited by: recover despite the absence of an auditory brainstem response (ABR) or brainstem David J. Margolis, Rutgers–New Brunswick, USA acoustic reflexes, and only a partial recovery of sound processing at the level of Reviewed by: the inferior colliculus (IC), an auditory midbrain nucleus. In this study, we induced a Robert C. Froemke, profound cochlear neuropathy with ouabain and asked whether central gain enabled New York University, USA Shaowen Bao, a compensatory plasticity in the auditory thalamus comparable to the full recovery University of Arizona, USA of function previously observed in the ACtx, the partial recovery observed in the IC, *Correspondence: or something different entirely.
    [Show full text]
  • Identification and Management of Infants and Young Children with Consensus
    Guidelines for Identification and Management of Infants and Young Children with Auditory Neuropathy Spectrum Disorder Guidelines Development Conference at NHS 2008, Como, Italy More Hearing. Slim Design. WaterResistant. Now available: Naída, designed for moderately-severe to profound hearing loss. Restoration of high frequency audibility and uncompromised performance. Get the power to change life, now for all degrees of significant hearing loss. www.naida.phonak.com Guidelines for Identification and Management of Infants and Young Children with Auditory Neuropathy Spectrum Disorder Co-Chairs Deborah Hayes, PhD Co-Chair, Bill Daniels Center for Children’s Hearing Kelley Family/Schlessman Family Scottish Rite Masons Chair in Childhood Language Disorders The Children’s Hospital – Colorado Yvonne S. Sininger, PhD Professor, Head and Neck Surgery David Geffen School of Medicine University of California, Los Angeles Los Angeles, California Editor Jerry Northern, PhD Professor Emeritus University of Colorado School of Medicine Colorado Hearing Foundation Denver, Colorado Conference and Editorial Assistant Valerie Hernandez Program Assistant Bill Daniels Center for Children’s Hearing The Children’s Hospital – Colorado This monograph is sponsored in part by a generous grant from the Kelley Family/Schlessman Family Scottish Rite Masons Chair in Childhood Language Disorders The Children’s Hospital – Colorado ©2008 The Children’s Hospital – Colorado, Aurora, Colorado USA. All Rights Reserved. The ONLYONLY handheld OAE-Tympanometry combination system... Audiologists Physicians Birth-to-3 Programs School Health TM BENEFITS • Sequenced protocols permit a full test battery with the press of only one button. • OAE and tympanometry are completed in as little as 20 seconds. • Easy operation for every level of tester.
    [Show full text]
  • Assessment of the Ear and Otoacoustic Emission Findings in Fibromyalgia Syndrome
    Clinical and Experimental Rheumatology 2005; 23: 701-703. BRIEFPAPER Assessment of the ear ABSTRACT nostic purposes (3-5). and otoacoustic emission O b j e c t i v e . We aimed to assess oto - The OAE findings of the patients with findings in fibromyalgia acoustic emission (OAE) findings in FM syndrome have remained unclear fibromyalgia (FM) syndrome. to date. The objective of this study was syndrome Methods. Thirty-two ears of 16 female to address this issue and assess OAE patients with FM syndrome and 30 ears findings in FM syndrome. 1 1 M. Yilmaz , E. Baysal , of 15 healthy female controls were also B. Gunduz2, A. Aksu3, included in the study. Pure tone audio - Materials and methods N. Ensari1, J. Meray3, m e t ry, speech discrimination testing, Thirty-two ears of 16 female patients Y.A. Bayazit1 t y m p a n o m e t ry and otoacoustic emis - who were diagnosed as having FM sion testing (both transiently evoked syndrome were included in the study 1Department of Otolaryngology, 2Depart- and distortion product) were perform - after informed consent was obtained. ment of Audiology, and 3Department of ed. The ages of patients ranged from 22 to Physical Medicine, Faculty of Medicine, Results. There was no significant dif - 45 years (31.5 years). Thirty ears of 15 Gazi University, Besevler, Ankara, Turkey. ference between the pure tone hearing healthy females were also included in Metin Yilmaz, MD, Assistant Professor; results of the patients and controls (p > the study and comprised of the control Elif Baysal, MD, Resident; Bulent Gunduz, PhD, Speech Language Pathologist; At i l l a 0.05).
    [Show full text]