Rotational Thromboelastometry and Standard Coagulation Tests for Live Liver Donors
© 2013 John Wiley & Sons A/S. Clin Transplant 2013 DOI: 10.1111/ctr.12067 Rotational thromboelastometry and standard coagulation tests for live liver donors Mohammed M, Fayed N, Hassanen A, Ahmed F, Mourad W, El Maged Mohammeda, Nirmeen Sheikh M, Abofetouh F, Yassen K, Khalil M, Marwan I, Tanaka K. Fayedb, Ashraf Hassanenb, Fatma Rotational thromboelastometry and standard coagulation tests for Ahmedb, Wessam Mouradc, Maha live liver donors. El Sheikhb, Fawzia Abofetouha, Khaled Yassenb, Magdy Khalilb, Abstract: Purpose: To study coagulation of live liver donors with Ibrahim Marwand and Koichio standard coagulation tests (SCT) and rotational thromboelastometry Tanakad (ROTEM) and investigate their relationship. a Methods: A descriptive prospective study involving 50 right hepatotomy Department of Anaesthesia, Cairo University, b donors with epidural catheters. ROTEM (EXTEM, INTEM, and Cairo, Department of Anaesthesia, Liver FIBTEM represent extrinsic and intrinsic pathways of coagulation and Institute, Menoufiya University, Shebeen El c fibrinogen activity, respectively) was measured perioperatively and on Kom, Department of Community Medicine days 1, 3, 5, 10, and 30. SCTs include prothrombin time (PT), and Statistics, Liver Institute, Menoufiya d international normalized ratio (INR) of PT, activated partial University and Department of Surgery, Liver thromboplastin time (aPPT), fibrinogen, and platelets. Institute, Menoufiya University, Shebeen El Results: PT and INR reflect hypocoagulability reaching maximum on Kom, Egypt day one (16.9 Æ 2.5 s, 1.4 Æ 0.2, p < 0.05 compared with baseline). ROTEM was in normal ranges till day 30 with no hypercoagulability. Key words: coagulation – live donors – liver Fibrinogen showed no correlation with maximum clot firmness (MCF) of resection – rotational thromboelastometry FIBTEM (r = 0.35, p > 0.05).
[Show full text]