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Sir James Black, the Hoxsey Film Published by the AMERICAN BOTANICAL COUNCIL and the HERB RESEARCH FOUNDATION No. 18/19 Faii1988/Winter 1989 FEATURE ARTICLE: ST. JOHN'S WORT Used for centuries in European folk medicine, this herb is being studied for its potential anti-retroviral activity. Page 24. SPECIAL REPORT: HUPERZIA: HYPE OR HOPE? Compounds from this traditional Chi­ nese herb are being researched for possible treatment of Alzheimer's disease. Page 21. MEDIA WATCH: Sir James Black, recipient of the Nobel Prize for his work on drug development supports Evening Primrose Oil research. Page 8. The Hoxsey Film A new documentary asks: "Did the Hoxsey cancer cure really work?" Plus, Dr. Jim Duke's review of this herbal formula. Page 11 . St. John's Wort Hypericum perforatum, from The Natural History MARKET REPORT, MEDIA of Plants, WATCH, BOOK REVIEWS, H ~ Baillon,1880 HERB BLURBS, POTPOURRI, CONFERENCE REPORTS, AND MORE ... FROM THE EDITOR ABOUT THIS ISSUE Regular readers of HerbaJGram will A Quick Look at This Issue a brief essay on the antitumor potential immediately note that with this issue Once again we are publishing a of some of the compounds found in the we have significantly changed our for­ major literature review by Christopher Hoxsey herbs. mat Not only are we adding color to Hobbs, a third generation botanist and We briefly profile Sir James Black, the cover and inside pages, but our en­ herbal author who lives in Santa Cruz, one of the three recent winners of the tire layout has been improved, with Cal. This time it is StJohn's Wort. Nobel Prize for medicine, who has had more botanical illustrations and other which we consider an important botani­ a remarkable career in pharmaceutical graphic changes, increasing the overall cal. Hobbs wrote the excellent review drug development. Of interest to our readability, and, hopefully, interest. of Sarsaparilla in our last issue. This readers is the fact that Sir James is one The format changes are a result of has been reprinted in an eight-page of the leading researchers and propo­ the efforts of our new art director, Ira monograph form by ABC as part of its nents of the therapeutic values of Kennedy, who brings over 25 years ex­ reprint project. (There will be more in­ Evening Primrose Oil. perience in art, photography, illustra­ formation on reprints at a later date.) Finally, Professor Ara Der tion, layout. and editorial experience We chose St John's Wort because Marderosian gives us a summary of the with him. The addition of Kennedy to of the recent flurry of interest that fol­ 5th International Ginseng Symposium the Herba/Gram staff is a result of a lowed a report by the National Acad­ held concurrently with the Olympic deeper more significant change, the for­ emy of Sciences indicating possible games in Seoul last fall. The research mation of a new organization, the anq-retroviral activity for some of the on this fabled herb continues in Asia American Botanical Council (ABC). chemical components of this plant As and Europe, but not in the United (See story on page 4.) Hobbs points out, St John's Wort has States and Canada. Ironically, the only Due to organizational requirements been used extensively in European remaining segments of the world's wild inherent in setting up a new non-profit herbal medicine. It is considered a population are still commercially viable corporation, and because of the holi­ boon by many herbalists, a noxious for harvest. days, we are printing a double issue of weed by others, a potential toxin to We hope you will find much bene­ Herba/Gram. This issue represents livestock, and formerly an (incorrectly fit in this expanded issue of Herbal­ both Fall 88 and Winter 89 editions classed) unsafe herb to the FDA. Gram and invite you to let us know (numbers 18 and 19). Subscribers Our Technical Editor, Rob Mc­ your opinions on our content and our please note that. with respect to sub­ Caleb, gives additional information on new format. scriptions, we consider this one issue. the recent St John's Wort study in his In effect, with this double issue, our "Research Reviews" on page 18. subscribers and HRF members are re­ Readers are cautioned not to con­ ceiving an extra bonus issue. fuse Hobbs's article on St. John's Wort (Hypericum) with Steven Foster's essay Addition to the on Huperzia, a Chinese medicinal plant HRF Advisory Board whose alkaloids have recently been We would like to offer a hearty shown to have some potential benefit welcome to Andrew Weil, M.D., a new for Alzheimer's patients. We include a member of the HRF Advisory Board. brief note from Dr. Alan Kozikowski, Dr. Weil is a noted author and lecturer the primary U.S. researcher on the NEW ADDRESS in the areas of medicinal plants and bo­ chemistry of Huperzia alkaloids. tanical drugs. He is a graduate of Har­ On the more controversial side, we We ask our readers to note that vard University where he studied under have devoted some space to report on ABC and HerbalGram now share the eminent Professor Richard E. the recently released documentary film a new address and phone number: Schultes, aclcnowledgedly one of the on Harry Hoxsey,whose herbal formula P.O. Box 201660, Austin, Texas, leading experts on the subject of me­ received wide notoriety as a reputed USA 78720. Phone 512/331- dicinal plants in the world. Dr. Wei! is cancer cure. Hoxsey was continually at 8868. FAX 512/331-1924. author of numerous books and currently odds with both the AMA and the FDA teaches at the University of Arizona and was eventually forced to close his Our mail permit does not allow School of Medicine. He lives in 17 cancer clinics. Without making a HerbaJGram to be forwarded. If Tucson where he also has a clinical case for or against Hoxsey, we offer a you move or change your mailing practice. You will find a review of his report on Santa Fe filmmaker Ken address, please notify us immedi­ recent book Health and Healing on Ausubel's compelling documentary. ately so you will not miss any cop­ page 37. Contributing Editor Jim Duke presents ies. Page 2- HerbalGram No. 18/19- Faii19881Winter 1989 ~f1'HERBAfGRAM CONTENTS HerbaiGram Nos. 18/19. Fall 1988/Winter 1989 The Amerk:an Botanical Couacll From the Editor ................................._ ...................................... 2 Board of Trustees Mark Blumenthal, Executive Director Acceaa and Letters ................................................................... 4 James A. Duke, Ph.D. Norman R. Farnsworth, PhD. Herb Blurbs ............. - •••••• -··········-·······•••••••••••••••••••••••• .. ••••• ...... 5 * How Did Van Gogh? * Can Wintergreen Light Up Your Smile? The Herb Researcll Foundatloo * Flax Facts * Tobacco Headed Down Primrose Path In Canada *Chaparral: One of Oldest Plants on Earth?* Did You Read Your President • Rob McCaleb Morning Kenaf? * Epazote: Herbal Cure for Greenhouse Effect? Wintergreen your smile, * Pepped-Up Potency In Herbs p. 5 Each issue of HerbaiGram is reviewed by the Herb Research Foundation Media Watch ······························--············................................ & * Nobel Laureate Supports Natural Products Research * Mate Professional Advisory Board prior to publi· Production Rises in Argentina * Marijuana, Cranberries: Gaining cation. Respect * Herbs Ate Becoming a Big Business in China * Notable Northwest Herbalists* Japanese Researchers on Northwest Herb HRF Professional Advkory Board Walk * African Herbal Medicine * The Hoxsey Rim: Can Healing Be a Crime? * The Synthetic Silver Bullet vs. The Herbal Shotgun Dr. Glenn Appelt Shell Professor of Pharmacology Dr. John A. Beutler Market Report .......................................................................... 14 Na111ral Products Chemist * Pent-up Demand Surfaces for Herbs/Spices Dr. Robert A. Bye, Jr. * Ephedrine Supplies Become Tighter Professor of Etlmobotany Dr. Subhuti Dhannananda Conference Reports ................................................................ 16 Evening Primrose and Director, Institute for * 36th Annual Congress of the Society for Medicinal Plant Research the Nobel Laureate. p. 8 Traditional Medicine *5th International Ginseng Symposium, Seoul, Korea Dr. James A. Duke Plant Taxonomist Research Reviews .................................................................. 18 Dr. Norman R. Farnsworth *Garlic Review* New Clinical Trial on Garlic* AIDS News: St. John's Wort Inhibits Retrovirus * Souped-up Polysaccharide Research Professor of Pharmacognosy Against HIV * New Feverfew Headache Research * Guar Gum Dr. Richard L Ford for the Heart * Spirulina Returns to the News * Cranberry Juice Professor of Erlrnobotany for Urinary Tract Infections Dr. Harriet Kuhnlein Professor of Nutrition Special Report- Huperzla: Hype or Hope? ........................ 21 Dr. Walter Lewis * Steven Foster writes on research that indicates possible new Professor of Biology drug for Alzheimer's patients from a traditional Chinese herb. Huperzia: Hype 0( Dr. Albert Leung Hope, p. 21 Pharmacognosist Calendar ................................................................................... 23 Dr. Ara Dec Marderosian Professor of Pharmacognosy Cover Feature .......................................................................... 24 Dr. C. Dwayne Ogzewalla *St. John's Wort (Hypericum perloratum)- A Uterature Review by Professor of Pharmacognosy Christopher Hobbs Dr. James Ruth Professor of Medical Chemistry Potpourrl ....................................... - ......................................... 34 Dr. E. John Staba * Native American Medicinal Plant Stamps * Flora of China
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