Appendix Receptor-Ligand Reference Guide 338 G Protein-CoupledReceptors Receptor-Ligand Reference Guide Use these tables to help you select cloned receptors and complementary NEN for your research. Our wide range of range wide Our research. your for Radioligands NEN complementary and receptors cloned select you help to tables these Use Key: Receptor-Ligand ReferenceGuide Non-recombinant * receptor membrane preparations includes G protein-coupled receptors (pp. 338–346), ion channel receptors (p. 347), transporters transporters 347), (p. receptors channel ion 338–346), (pp. receptors protein-coupled G includes preparations membrane receptor ** For sales in the United States: These products can ONLY be sold to customers who hold a license from the University of Michiga of University the from license a hold who customers to sold be ONLY can products These States: United the in sales For ** (p. 350) and tyrosine kinase receptors (p. 351). Radioligands for other classes of receptors are also listed. If you do not see not do you If listed. also are receptors of classes other for Radioligands 351). (p. receptors kinase tyrosine and 350) (p. deoeulnCRLR+Human Adrenomedullin A Adenosine β α receptor you need, please inquire. please need, you receptor eetrTp utp pce otPoutN.Ligand No. Product Host Species G Protein-CoupledReceptors Subtype Receptor Type For detailed information about our cloned receptor membrane preparations, please see pp. 190–192. For a complete listing of NEN of listing complete a For 190–192. pp. see please preparations, membrane receptor cloned our about information detailed For Adrenergic Radioligands, please see the radiochemicals product listing beginning on p. 46. p. on beginning listing product radiochemicals the see please Radioligands, Adrenergic For sales outside of the United States: These products can ONLY be sold to Licensed Customers or to customers who are incorporat are who customers to or Customers Licensed to sold be ONLY can products These States: United the of outside sales For United States AND whose principal place of business is in such territory of incorporation. of territory such in is business of place principal whose AND States United Order Online: For country-specific orderinginformation,visit www.perkinelmer.com/lasoffices orseepage4 Order byPhone: lndRcpo ebaePeaain NENRadioligands Cloned ReceptorMembranePreparations β A β A A RAMP2 β A A β α α α 3 2A 2A 1 1 1 3 2 2 1 2A 2A ua KNM BB340ADihydroalprenolol NET720 Antagonist SK-N-MCRBHBE3M400UA Human hydrochloride, * ua T2 RH2M0U Clonidine RBHL2AM400UA hydrochloride, * Human HT-29 ua f 10001T()Caoidll [ (-)-, [5,7- (-)-CGP-12177, 6110106001KT 6110110001KT [ (±)-Cyanopindolol, RBHBE2M400UA Human HEK293 Sf9 EBNA Human Sf9 Human [benzene ring- 6110114001KT p-[ Iodoclonidine, 5'-N-[adenine-2,8- 6110113001KT [ AB-MECA, 6110536001KT A Human Sf9 RBRA3M400UA [carboxyethyl- A CGS21680, Human Sf9 HEK293EBNA Ethylcarboxamidoadenosine, 8-[dipropyl-2,3- RBHA2AM100UA CHO Cyclopentyl-1,3-dipropylxanthine, 6110542001KT Rat 6110511001KT 6110120001KT Rat HEK293 Human CHO CHO Human Sf9 Rat Rat www.perkinelmer.com/online Sf9(G 1-800-762-4000 or203-925-4600 α s β 1 γ 2 ) 10301TArnmdli Tr,[ Adrenomedullin(Tyr), 6110136001KT BAA40AEhlabxmdaeoie A Ethylcarboxamidoadenosine, RBHA2AM400UA --idll [ (-)-, K1,0,[imidazolyl-4,5- UK-14,304, ET [ HEAT, 5'-N-[adenine-2,8- rpaoo,L-[4- , [ Prazosin analog, levo-[ring-2,5,6- Norepinephrine, (4-amino-3-[ eo[ig propyl- levo-[ring, rzsn [7-methoxy- Prazosin, levo-[N-methyl- Epinephrine, [methyl- , [methyl- , [methyl- MK-912, 125 I]- 125 125 125 ],A I]-, 3 H]- I]iodobenzyl-5'-N-) I]iodo- Antagonist NEX211 3 H(N)]- 125 3 3 125 3 H]- Antagonist NET515 H(N)]- H]- 125 3 3 125 3 I]-, H]- H]- I]iodoazido- H]- 3 ]oo naoit NEX189 I]iodo- Antagonist 3 3 ] AntagonistNET1061 H]- ]oo naoit NEX174 I]iodo- Antagonist 125 H]- H]- ],(35)AdrenomedullinNEX385 (13–52) I]-, 3 ()-A H(N)]- 3 3 H]- ] noeos NET623 H]- Endogenous 3 ] noeos NET678 H]- Endogenous α receptor agonist α α α α α α α α Pharmacological Action 2 1 1 3 1 1 1 1 2 2 2 2 2 2 ,A ,A agonist NET1021 antagonist NET974 gns NEX312 agonist antagonist NEX219 antagonist NET823 antagonist NEX182 antagonist NET659 antagonist NET722 antagonist NET1059 agonist NET853 agonist NET613 agonist NEX253 2 2 n (“Licensed Customers”). (“Licensed n gns NET811 agonist NET811 agonist ed outside of the the of outside ed a cloned a Product No. Receptor-Ligand Reference Guide Appendix 339 Product No. agonist , NEX295 1 2 antagonistantagonist NEX248 NEX324 antagonist NET1096 agonist NET1064 2 2 1 1 receptor agonist CCR5, endogenous endogenous Non-AT CCR5, endogenous Pharmacological Action Pharmacological I]- CGRP, endogenous NEX354 125 I]- APJ agonist NEX393 I]- AT 125 H(N)]- Agonist NET1051 125 H]- Agonist NET1058 3 3 ), [ H(N)]- Endogenous NET706 ), [ 3 8 77 I]- CCR5, endogenous NEX299 I]- Adrenomedullin NEX385 I]- , agonist BRS3 NEX377 I]- Non-AT ), B 6 I]- Endogenous NEX105 , Ile 9 I]- Endogenous NEX101 125 H]- 4 125 ,Tyr 125 I]- CXCR2, endogenous NEX321 125 3 125 125 G Protein-Coupled Receptors G Protein-Coupled 75 I]-I]- Agonist Agonist NEX258 NEX258 ), [ ), [ 125 ), [ ,Tyr ), [ 47 2 , Leu ), B 1 ), [ I]- AT 14 4 125 125 I]- CXCR1, CXCR2, NEX277 4 10 10 H(N)]- H(N)]- ,Nle 3 3 125 ), [ ), [ 125 65 4 4 ,Gly ,Nle 3 I]- CCR1, CCR3, CCR4, NEX292 I]- CXCR6, endogenous NEX398 I]-, (human, recombinant) CCR6, endogenous NEX371 I]- CCR1, CCR4, NEX298 I]-, Bolton-Hunter labeled CCR7, endogenous NEX387 I]- CCR7, endogenous NEX370 I]- CCR3, endogenous NEX314 I]-, CCR2, endogenous NEX332 13 I]- CCR10, endogenous NEX391 125 125 I]- CCR4, endogenous NEX369 125 125 125 125 I]-, Bolton-Hunter labeled CCR8, endogenous NEX364 125 125 125 ,[ ,[ ,[ , (Leu 125 I]-, Bolton-Hunter labeled, CCR2 agonist NEX313 125 , Phe β α α β 11 125 Ala MIP-3 β I309, [ CTACK, [ Angiotensin II (Tyr [3,4-prolyl-3,4- (murine, recombinant MCP-1) Eotaxin, [ Bombesin (Tyr Kallidin (Des-Arg TARC, [ Angiotensin II (Sar CGP 42112A, [ Angiotensin IV (Tyr MIP-3 [3,4-prolyl-3,4- RANTES, [ Bolton-Hunter labeled JE, [ 6-Ckine, [ Kallidin (Des-Arg MIP-1 Receptor-Ligand Reference Guide Reference Receptor-Ligand RBHCB1M400UA WIN 55212-2, [5,7-naphthyl- RBXCB2M400UA 6110132001KT GRO alpha/MGSA, [ 6110129001KT Anandamide, [arachidonyl-6110130001KT CB, endogenous NET1073 6110135001KT Adrenomedullin (Tyr), [ ) ) ) ) 2 2 2 2 γ γ γ γ 1 1 1 1 β β β β s i3 i3 i3 α α α α [email protected] (G Sf9(G Sf9(G Sf9(G www.perkinelmer.com/reagents Human Human HEK293 EBNAHuman RBXCB2M100UA 5,6,8,9,11,12,14,15- Human CHO RBHB2M400UA Bradykinin, [2,3-prolyl-3,4- Human HEK293 EBNA RBHCB1M100UA CP 55940, [side chain-2,3,4- Human Sf9Human CHO 6110121001KT 6110533001KT Angiotensin I (Tyr 2 1 1 2 1 1 2 CB CXCR2 Human CXCR6 HumanPlease inquire for HEK293 receptor availability. RBHCX6M400UA CXCL16, [ CB CCR2b Human HEK293 6110550001KT MCP-1, [ RAMP1 Please inquire for receptor availability. BRS2BRS3 Human HEK293 Human3T3 Balb RBHBS2M400UA RBHBS3M400UA Bombesin (6–14) (D-Tyr AT CXCR2 Human CHO 6110524001KT Interleukin-8, [ CB Cloned Receptor Membrane PreparationsCloned Receptor NEN Radioligands Related Peptide CRLR+ Human Sf9 Chemokine CCR1 Human HEK293 RBHCC1M400UA MIP-1 Bradykinin B Apelin APJ Human CHO 6110561001KT Apelin 13 (Glp Angiotensin AT Cannabinoid CB Calcitonin Gene CGRP* Human SK-N-MC RBHGRPM400UA Peptide, Calcitonin Gene-Related [ Bombesin BRS1 Human CHO(Tyr RBHBS1M400UA Bombesin G Protein-Coupled Receptors G Protein-Coupled Receptor Type Subtype Species Host Product No. Ligand Customer Support e-mail: [email protected] Support e-mail: [email protected], Technical Visit our website at Receptor-Ligand Reference Guide G Protein-Coupled Receptors

Cloned Receptor Membrane Preparations NEN Radioligands Receptor Type Subtype Species Host Product No. Ligand Pharmacological Action Product No. G Protein-Coupled Receptors

Chemokine (cont) Please inquire for receptor availability. Fractalkine, [125I]- CX3CR1, endogenous NEX368 I-TAC, [125I]- CXCR3, endogenous NEX376 IP-10, [125I]-, Bolton-Hunter labeled CXCR3, endogenous NEX348 SDF-1α,[125I]- CXCR4, endogenous NEX346

Cholecystokinin CCKA Human Sf9 6110125001KT Cholecystokinin octapeptide, CNS peripheral NEX203 125 & Gastrin CCKA Human NIH-3T3 6110508001KT [ I]-, Bolton-Hunter labeled

CCKA Human NIH-3T3 RBHCKAM400UA

CCKB Human HEK293 RBHCKBM400UA Cholecystokinin octapeptide, CNS peripheral NEX203 [125I]-, Bolton-Hunter labeled Gastrin I (Tyr12), [125I]-, (human) Endogenous NEX176 Cholinergic Please inquire for receptor availability. Choline chloride, [methyl-3H]- Endogenous NET109 (Acetylcholine) 3 Cholinergic M1 Human CHO RBHM1M100UA Pirenzepine, [N-methyl- H]- M1 antagonist NET780 3 (Acetylcholine) RBHM1M400UA 4-DAMP, [N-methyl- H]- M1,M3 antagonist NET1040 3 Muscarinic Oxotremorine-M acetate,[methyl- H]- M1–M5 agonist NET671 Receptor-Ligand Reference Guide Reference Receptor-Ligand Quinuclidinyl benzilate, M1–M5 antagonist NET656 L-[benzilic-4,4'-3H]-

Scopolamine methyl chloride, M1–M5 antagonist NET636 [N-methyl-3H]- 3 Acetylcholine iodide, [acetyl- H]- M1–M5 agonist, endogenous NET113 3 M2 Human CHO RBHM2M100UA AF-DX 384, [2,3-dipropylamino- H]- M2 antagonist NET1041 3 RBHM2M400UA Oxotremorine-M acetate, [methyl- H]- M1–M5 agonist NET671

Quinuclidinyl benzilate, M1–M5 antagonist NET656 L-[benzilic-4,4'-3H]-

Scopolamine methyl chloride, M1–M5 antagonist NET636 [N-methyl-3H]- 3 Acetylcholine iodide, [acetyl- H]- M1–M5 agonist, endogenous NET113 3 M3 Human CHO RBHM3M100UA 4-DAMP, [N-methyl- H]- M1,M3 antagonist NET1040 3 RBHM3M400UA Oxotremorine-M acetate, [methyl- H]- M1–M5 agonist NET671

Quinuclidinyl benzilate, M1–M5 antagonist NET656 L-[benzilic-4,4'-3H]-

Scopolamine methyl chloride, M1–M5 antagonist NET636 [N-methyl-3H]- 3 Acetylcholine iodide, [acetyl- H]- M1–M5 agonist, endogenous NET113 3 M4 Human CHO RBHM4M100UA Oxotremorine-M acetate, [methyl- H]- M1–M5 agonist NET671

RBHM4M400UA Quinuclidinyl benzilate, M1–M5 antagonist NET656 L-[benzilic-4,4'-3H]-

Scopolamine methyl chloride, M1–M5 antagonist NET636 [N-methyl-3H]- 3 Acetylcholine iodide, [acetyl- H]- M1–M5 agonist, endogenous NET113 3 M5 Human CHO RBHM5M100UA Oxotremorine-M acetate, [methyl- H]- M1–M5 agonist NET671

RBHM5M400UA Quinuclidinyl benzilate, M1–M5 antagonist NET656 L-[benzilic-4,4'-3H]-

Scopolamine methyl chloride, M1–M5 antagonist NET636 [N-methyl-3H]- 3 Acetylcholine iodide, [acetyl- H]- M1–M5 agonist, endogenous NET113 Appendix

Order by Phone: 1-800-762-4000 or 203-925-4600 For country-specific ordering information, visit www.perkinelmer.com/lasoffices or see page 4 340 Order Online: www.perkinelmer.com/online Receptor-Ligand Reference Guide Appendix 341 Product No. agonistagonistantagonist NET1085 NEX307 NET856 agonistagonistantagonist NET1085 NEX307 NET856 antagonist NET930 antagonist NET930 3 3 3 3 3 3 5 5 antagonistantagonistantagonist NET565 antagonist NEX284 NET775 NET1004 antagonist NET975 ,D ,D ,D ,D ,D ,D ,D ,D 2 2 2 2 2 2 2 2 2 2 1 1 2 Pharmacological Action Pharmacological H]- Endogenous NET131 3 I]- D I]- D 125 125 H]- D H]- D 3 3 H]- D H]- D 3 3 H]- D H]- D 3 3 H]- D H]- D H]- D H]- D 3 I]-,I]-, C3a, endogenous C5a, NEX356 endogenous NEX250 3 3 3 G Protein-Coupled Receptors G Protein-Coupled ]- CRF agonist NEX306 125 125 0 I]iodo- D H]-, () H]-, (Dopamine) H]-, (Dopamine) H]-, (Dopamine) 3 3 3 3 125 I-Tyr H]-, (Dopamine) 125 3 I]-, (ovine) I]-, (human, rat) H]- H]-, H]- H]- 3 3 3 3 125 125 ), [ ), [ 0 0 Dihydroxyphenylethylamine, Endogenous NET673 (-)Sulpiride, [methoxy- YM-09151-2, [N-methyl- Quinpirole, [N-propyl- Dihydroxyphenylethylamine,3,4-[7- Endogenous NET131 Dihydroxyphenylethylamine, Endogenous NET673 R (+) trans-7-hydroxy-PIPAT, [ Methylspiperone, [N-methyl- Dihydroxyphenylethylamine, 3,4-[7- R (+) trans-7-hydroxy-PIPAT, [ Methylspiperone, [N-methyl- Dihydroxyphenylethylamine,3,4-[7- Dihydroxyphenylethylamine, Endogenous Endogenous NET131 NET673 Dihydroxyphenylethylamine,3,4-[7- Endogenous NET131 Dihydroxyphenylethylamine, 3,4- Endogenous NET673 Corticotropin Releasing Factor Corticotropin Releasing Factor Endogenous NEX216 3,4-[ring-2,5,6- 3,4-[ring-2,5,6- 3,4-[ring-2,5,6- Bolton-Hunter labeled Bolton-Hunter labeled (Tyr [ring-2,5,6- Receptor-Ligand Reference Guide Reference Receptor-Ligand RBHD2CM400UA 2'-, -[ RBHD42M400UA Dihydroxyphenylethylamine, Endogenous NET673 [email protected] www.perkinelmer.com/reagents Human Sf9Human CHOHuman CHOHuman Sf9Human CHOHuman 6110122001KT HEK293 6110520001KT 3,4-[ring-2,5,6- RBHD44M400UA 23390,[N-methyl- 6110123001KT RBHD47M400UA RBHD5M400UA SCH Rat Sf9 6110139001KTHuman Quinpirole, [N-propyl- Sf9Human CHO 6110112001KT RBHD42M100UA Dihydroxyphenylethylamine, 3,4-[7- Endogenous NET131 Human L Cells 6110513001KTHuman SCH 23390, Sf9Human [N-methyl- CHO 6110137001KT RBHD2CM100UA Raclopride, [methoxy- Spiperone, [benzene ring- 4.7 4.7 5 4.2 4.2 4.4 4.4 4.4 3 2L 2s 1 D D D D D D C5a Human CHO 6110526001KTC5a,[ Complement D D D D D Cloned Receptor Membrane PreparationsCloned Receptor NEN Radioligands Dopamine D Corticotropin CRF1 Human HEK293 RBHCRF1M400UA Sauvagine, [ Complement Complement C3a, [ ReleasingFactor Corticotropin Releasing Factor (Tyr CRF agonist NEX217 Receptor Type Subtype Species Host Product No. Ligand G Protein-Coupled Receptors G Protein-Coupled Customer Support e-mail: [email protected] Support e-mail: [email protected], Technical Visit our website at Receptor-Ligand Reference Guide G Protein-Coupled Receptors

Cloned Receptor Membrane Preparations NEN Radioligands Receptor Type Subtype Species Host Product No. Ligand Pharmacological Action Product No. G Protein-Coupled Receptors

Endothelin ETA Human CHO 6110547001KT Endothelin-1 (Tyr13), [125I]-, Endogenous NEX259 (human, porcine) Formyl-Methionyl FPR1 Human CHO 6110527001KT WKYMVm, [125I]-, FPR1, FPRL1 agonist NEX386 Peptides FPRL1 Human CHO 6110563001KT Bolton-Hunter labeled GABA B1a Human CHO 6110545001KT Baclofen, (-)-[butyl-4-3H(N)]- GABA-B agonist NET867 B1b Human CHO 6110546001KT Aminobutyric acid, γ-[2,3-3H(N)]- Endogenous NET191 B1a Human HEK293 6110560001KT Aminobutyric acid, γ-[2,3-3H(N)]- Endogenous NET191X B1b Human HEK293 6110557001KT Butyl bicyclophosphorothionate, Cl-channel non- NEG049 B1a + R2 Human HEK293 6110559001KT tertiary-[35S]- competitive antagonist B1b + R2 Human HEK293 6110556001KT Galanin GalR1 Human HEK293 EBNA6110537001KT Galanin (Tyr26), [125I]-, (porcine) Galanin agonist NEX243 GalR1 Human HEK293 EBNA RBXGL1M400UA Galanin, [125I]-, (human) Galanin, endogenous NEX333 GalR2 Human CHO RBHGL2M400UA Galanin (Tyr26), [125I]-, (porcine) Galanin agonist NEX243 Galanin, [125I]-, (2–11) GalR2, GalR3 agonist NEX416 Galanin, [125I]-, (human) Galanin, endogenous NEX333 Receptor-Ligand Reference Guide Reference Receptor-Ligand Gastric Inhibitory GIP Human HEK293 RBHGIPM400UA Gastric Inhibitory Polypeptide, [125I]- Endogenous NEX402 Peptide Ghrelin GHS-R Human HEK293 RBHGHSM400UA Ghrelin (His), [125I]-, (human) GHS-R, endogenous NEX388 Ghrelin (Tyr4), [125I]- GHS-R agonistNEX417 Glucagon Please inquire for receptor availability. Glucagon, [125I]- Endogenous NEX207 Glucagon-Like Please inquire for receptor availability. Exendin, [125I]-, (9–39) GLP-1 antagonist NEX335 Peptide GLP-1, [125I]-, (7–36) GLP-1 agonist NEX308 GLP-2, [125I]- GLP-2 agonist NEX390 GPR8 GPR8 Human HEK293 RBHGP8M400UA Neuropeptide W23, [125I]-, (human) GPR8, endogenous NEX403 Neuropeptide B23 (Des-Br), [125I]- GPR8, endogenous NEX405 GPR103 GPR103 Human HEK293 RBH103M400UA QRFP-43, [125I]-, (human) GPR103, endogenous NEX408 3 Histamine H1 Human CHO 6110564001KT Pyrilamine, [pyridinyl 5- H]- H1 antagonist NET594 Histamine dihydrochloride, Endogenous NET732 [ring, methylenes-3H(N)]- 3 H2 Human HEK293 6110565001KT Tiotidine, [methyl- H]-, (ICI 125,211) H2 antagonist NET688 Histamine dihydrochloride, Endogenous NET732 [ring, methylenes-3H(N)]-

Methylhistamine dihydrochloride, H3 agonist NET1027 N-α-[methyl-3H]-

Leukotrienes Please inquire for receptor availability. Leukotriene B4, Endogenous NET852 [5,6,8,9,11,12,14,15-3H(N)]-

Leukotriene C4, Endogenous NET1018 [14,15,19,20-3H(N)]-

Leukotriene D4, Endogenous NET1019 [14,15,19,20-3H(N)]- Luteinizing Please inquire for receptor availability. Luteinizing Hormone Releasing LHRH receptor agonist NEX365 Hormone Hormone (D-Trp6), [125I]- Releasing Luteinizing Hormone Releasing LHRH receptor agonist NEX163 Hormone Hormone (Tyr5), [125I]- Appendix

Order by Phone: 1-800-762-4000 or 203-925-4600 For country-specific ordering information, visit www.perkinelmer.com/lasoffices or see page 4 342 Order Online: www.perkinelmer.com/online Receptor-Ligand Reference Guide Appendix 343 Product No. antagonist NEX362 antagonist NEX362 agonist NEX218 agonist NEX218 4 4 3 3 agonist NEX334 agonistagonist NEX372 NEX374 agonistagonist NEX414 agonistagonist NEX190 agonist NEX152 agonist NET1025 antagonist NET1115 NEX252 NET1077 agonistagonist NEX285 NET997 ,MC ,MC 1 ,NK ,NK 3 3 4 4 1 1 1 1 1 2 2 2 3 3 2 MCH receptor agonist NEX373 endogenous Pharmacological Action Pharmacological )), NK H]- NK 2 3 I]- NMU1, NMU2 agonist NEX383 I]- NPY H(N)]- NK I]- NK I]- EndogenousI]- Endogenous NEX315 NEX315 H]- NK 3 I]-, Neuropeptide S NEX411 125 125 3 I]-, (human) 125 125 125 I]- MC agonistI]-I]- NEX352 MC agonist MC agonist NEX352 NEX352 125 ormone, , NPFF1/NPFF2 agonist NEX381 ), [ ), [ I]- MC I]- NK 1 I]- NK 18 34 125 ), [ 125 125 125 ), [ I]- NMU1, NMU2 agonist NEX392 7 125 125 125 G Protein-Coupled Receptors G Protein-Coupled 10 I]-,I]-, NK NK ), [ ), [ ), [ 125 7 7 7 ), [ ), [ I]- MCH receptor agonist NEX396 I]-, NK , Pro I]-, NK 3 125 125 8 I]- Agonist NEX236 I]-, (human, mouse, rat) 31 I]- 125 I]-, (porcine)I]-, (human)I]-, (porcine) NPY agonistI]-, (human) Endogenous NPY agonist NEX240 Endogenous NEX341 NEX240 NEX341 125 I]- MC 125 H]- I]-I]- MC MC ), [ ), [ 125 125 3 4 4 I]-, (45–54) Mestastin agonist NEX395 , Phe , Phe , Phe 125 125 125 125 125 4 4 4 125 125 125 ), [ I]- Motilin receptor, NEX378 125 ), [ 19 3 125 ,Tyr 13 I]-, (human) I]-Substance K) -MSH (Nle -MSH (Nle -MSH (Nle 125 125 [ Melanin Concentrating H α Melanin Concentrating Hormone, receptor agonist MCH NEX375 Bolton-Hunter labeled Substance P (Lys Bolton-Hunter labeled Substance P (Tyr Substance P (9-Sar, 11-Met(O [2-prolyl-3,4- ([ Eledoisin (Lys Senktide, [phenylalanyl-3,4,5- Eledoisin (Lys Pancreatic polypeptide, [ Pancreatic polypeptide, [ Substance P, [leucyl-3,4,5- Bolton-Hunter labeled Bolton-Hunter labeled (human) agonist, endogenous (Phe S36057 (Tyr), [ α α Melatonin, 2-[ Peptide YY, [ Peptide YY, [ SR 48968, [benzamide-4- MT II (His), [ Receptor-Ligand Reference Guide Reference Receptor-Ligand RBHMC4M400UA AGRP (Ac-87-132),[ RBHMC4M400UA AGRP [email protected] www.perkinelmer.com/reagents Human Sf9 6110133001KT Peptide YY, [ Human CHOHuman 6110510001KT CHO Neurokinin A, [ 6110534001KT Neurokinin B (MePhe Human HEK293 EBNA RBXMC5M400UA * Human KAN-TS RBHNP2M400UA Peptide YY, [ * Human SK-N-MC RBHNP1M400UA YY Peptide (Leu ** Human** HEK293 Human HEK293 RBXMC3M400UA SHU9119, [ RBHMC4M100UA SHU9119, [ 2 1 1 * Human UC11 6110551001KT Hemokinin-1, [ 5 3 4 3 2 1 NK NK NPFF2 Human CHO RBHNF2M400UA N-MePhe NMU2 Human HEK293 RBHNU2M400UA Neuromedin U-8, [ MC Please inquire for receptor availability. NPY NPY MC Cloned Receptor Membrane PreparationsCloned Receptor NEN Radioligands Hormone Motilin MOT1 Human HEK293 RBHMOTM400UA Motilin, [ Neuromedin U NMU1 Human HEK293Neuropeptide Y RBHNU1M400UA NPY Neuromedin U-25 (Tyr Neuropeptide FF NPFF1 Human CHO-DHFR(-) RBHNF1M400UA Neuropeptide FF (D-Tyr Melatonin Metastin Metastin Human CHO RBHMTSM400UA Metastin, [ Melanin Concentrating MCH-1 Human CHO RBHMCH1M400UA Hormone-1 Melanin Concentrating MCH-1 antagonist NEX406 Receptor Antagonist, [ Neurokinin NK Melanocortin MC Neuropeptide S Neuropeptide S (Tyr G Protein-Coupled Receptors G Protein-Coupled Receptor Type Subtype Species Host Product No. Ligand Customer Support e-mail: [email protected] Support e-mail: [email protected], Technical Visit our website at Receptor-Ligand Reference Guide G Protein-Coupled Receptors

Cloned Receptor Membrane Preparations NEN Radioligands Receptor Type Subtype Species Host Product No. Ligand Pharmacological Action Product No. G Protein-Coupled Receptors

Neurotensin NTS1 Human CHO 6110518001KT Neurotensin (Tyr3), [125I]- Endogenous NEX198 NTS1 Human HEK293 RBXNT1M400UA Neurotensin, [3,11-tyrosyl-3,5-3H(N)]- Endogenous NET605 NT2 Human HEK293 6110566001KT Obestatin Please inquire for receptor availability. Obestatin, [125I]- Endogenous NEX415 Opioid δ-opioid Mouse Sf9 6110115001KT Naltrindole, [5',7'-3H]- Delta antagonist NET1065 (OP1) Enkephalin (2-D-alanine-5-D- Delta agonist NET648 δ-opioid Human CHO RBHODM400UA leucine), [tyrosyl-3,5-3H(N)]- (OP1) Enkephalin, (2-D-penicillamine, Delta agonist NET922 δ-opioid Human HEK293 6110549001KT 5-D-penicillamine), [tyrosyl-2,6- (OP1) 3H(N)]-, (DPDPE) Deltorphin II (2-D-Ala), [tyrosyl-3,5-3H]- Delta agonist NET1087 Diprenorphine, [15,16-3H]- Antagonist NET1121 κ-opioid Human HEK293 6110558001KT U-69,593, [phenyl-3,4-3H]- Kappa agonist NET952 (OP2) Diprenorphine, [15,16-3H]- Antagonist NET1121 µ-opioid Human CHO RBHOMM100UA Naloxone, [N-allyl-2,3-3H]- Mu antagonist NET719 Receptor-Ligand Reference Guide Reference Receptor-Ligand (OP3) RBHOMM400UA DAMGO, [tyrosyl-3,5-3H(N)]- Mu agonist NET902 Diprenorphine, [15,16-3H]- Antagonist NET1121 ORL-1 Human CHO 6110540001KT Nociceptin (Tyr14), [125I]- ORL-1 agonist NEX338 (OP4) Nociceptin, [leucyl-3,4,5-3H]- ORL-1 agonist NET1130 ORL-1 Human HEK293 RBHORLM100UA (OP4) RBHORLM400UA Orexin Please inquire for receptor availability. Orexin A, [125I]- ORX1, ORX2 agonist NEX367 Oxytocin Please inquire for receptor availability. Ornithine Vasotocin Analog, [125I]- Oxytocin antagonist NEX254 Oxytocin (Tyr2), [125I]- Endogenous NEX187 Oxytocin, [Tyr2,6-3H]- Endogenous NET858

Parathyroid Please inquire for receptor availability. Parathyroid Hormone amide PTH1, PTH2 agonist NEX353 Hormone (Nle8,21,Tyr34), [125I]-, (rat, 1–34) Parathyroid Hormone (Nle8,18,Tyr34), Endogenous NEX397 [125I]-, (human, 1–34) Platelet Please inquire for receptor availability. Hexadecyl-2-acetyl-sn-glyceryl- Endogenous NET910 Activating 3-phosphorylcholine, 1-O- Factor [acetyl-3H(N)]- Prokineticin PK1 Human HEK293 RBHPK1M400UA MIT-1, [125I]-, Bolton-Hunter labeled PK1, PK2 antagonist NEX410 Prolactin Please inquire for receptor availability. Prolactin, [125I]- Endogenous NEX108

Prostanoid CRTH2 Human HEK293 RBHTH2M400UA Prostaglandin D2, Endogenous NET616 [5,6,8,9,12,14,15-3H(N)]-

Prostaglandin E2, Endogenous NET428 [5,6,8,11,12,14,15-3H(N)]- TP Human HEK293 EBNA RBHTPM400UA SQ 29548, [5,6-3H(N)]- TP receptor antagonist NET936

Prostaglandin F2α, FP receptor agonist NET433 [5,6,8,9,11,12,14,15-3H(N)]- Purinergic Please inquire for receptor availability. α,β-Methylene-ATP, P2x-purinergic agonist NET1068 tetrasodium salt, [2,8-3H]- Relaxin Please inquire for receptor availability. H2 Relaxin, [125I]-, Bolton-Hunter labeled RXFP1(LGR7) agonist NEX409 H3 Relaxin, [125I]- RXFP1(LGR7) agonist NEX418 INSL-3, [125I]- RXFP2 (LGR8), RXFP3 NEX419 (GPCR135) agonist Appendix

Order by Phone: 1-800-762-4000 or 203-925-4600 For country-specific ordering information, visit www.perkinelmer.com/lasoffices or see page 4 344 Order Online: www.perkinelmer.com/online Receptor-Ligand Reference Guide Appendix 345 NEX389 Product No. 5 agonist NET1071 antagonist NEX174 agonistantagonist NET929 NET1109 agonistantagonistantagonist NEX255 NET565 NET791 1B 1D 1A 1A 2 2 2 –SST 1 Pharmacological Action Pharmacological H]-5- 5-HT 3 H]- 5-HT 3 I]- SST H(N)]- I]iodo- 5-HT 3 125 G Protein-Coupled Receptors G Protein-Coupled 125 ), [L-histidyl- ), [ 2 11 I]-LSD) I]-LSD) I]-LSD) I]-LSD) I]-LSD) H(N)]- H(N)]- H(N)]- H(N)]- H(N)]- H]- 5-HT 3 3 3 3 3 3 125 125 125 125 125 I]- 5-HT H]- H]- H]- H]- H]- H]- 3 H]-, (R41 468) 3 3 3 3 3 3 I]- 125 125 I]iodo-, ([ I]iodo-, ([ I]iodo-, ([ I]iodo-, ([ I]iodo-, ([ ), [ 2 H(N), L-propyl-3,4- 125 125 125 125 125 3 (+)-Lysergic acid diethylamide,(+)-Lysergic 2-[ Agonist NEX199 acid diethylamide,(+)-Lysergic 2-[ Agonist NEX199 (+)-Lysergic acid diethylamide, acid (+)-Lysergic 2-[ Agonist NEX199 acid diethylamide,(+)-Lysergic 2-[ Agonist NEX199 (±)-Cyanopindolol, [ Lysergic acid diethylamide,Lysergic [N-methyl- Agonist NET638 2-[ Thyrotropin Releasing Hormone TRH1, TRH2 receptors NET705 Thyrotropin Releasing Hormone (His TRH1, TRH2 receptors NEX153 sulfate, 5-[1,2- sulfate, 5-[1,2- sulfate, 5-[1,2- sulfate, 5-[1,2- Carboxamidotryptamine, [1,2- sulfate, 5-[1,2- Hydroxytryptamine creatinine Endogenous NET498 Hydroxytryptamine creatinine Endogenous NET498 Hydroxytryptamine creatinine Endogenous NET498 Hydroxytryptamine creatinine Endogenous NET498 ring-1,2,3- acid diethylamide, Lysergic [N-methyl- AgonistHydroxytryptamine creatinine Endogenous NET638 NET498 Spiperone, [benzene ring- hydrochloride,[ethylene- 5-HT Receptor-Ligand Reference Guide Reference Receptor-Ligand RBHST5M400UA RBHS6M400UA [N-methyl- RBHS5AM400UA [N-methyl- [email protected] www.perkinelmer.com/reagents HumanEBNA RBHST5M100UA HEK293 EBNA Human HEK293 RBHST4M400UA Somatostatin (Tyr Human HEK293Rat HEK293 RBHS6M100UA acid diethylamide, Lysergic RatHuman RBRS6M400UA HEK293 CHO diethylamide, acid (+)-Lysergic Agonist Agonist RBRS7M400UA 6110512001KT acid diethylamide, Lysergic NET638 [N-methyl- NEX199 Agonist NET638 Human HEK293 6110548001KT (±)-DOI, [ Human CHO RBHS5AM100UA acid diethylamide, Lysergic Agonist NET638 Human HEK293 EBNA Human RBHS1AM400UA CHO 8-hydroxy-DPAT, [propyl-2,3- 5-HT 6110501001KT MPPF, [methyl- 7 6 6 7 5A 2C 1A 1A 4 5 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Please inquire for receptor availability. SST 5-HT Cloned Receptor Membrane PreparationsCloned Receptor NEN Radioligands Hormone 4- Thyrotropin Releasing (3-methyl-histidine Somatostatin SST 5-HT G Protein-Coupled Receptors G Protein-Coupled Receptor Type Subtype Species Host Product No. Ligand Customer Support e-mail: [email protected] Support e-mail: [email protected], Technical Visit our website at Appendix Receptor-Ligand Reference Guide 346 G Protein-Coupled Receptors/Cytokines/Excitatory G Protein-CoupledReceptors/Cytokines/Excitatory Amino Acids Receptor-Ligand Reference Guide Interleukin rtni IUR Urotensin II Glycine Leptin netnl V Intestinal Aspartate Vasopressin V Polypeptide (VIP) Glutamate aocieVP ua T2 RBHVIPM400UA VasoactivePACAP VIP* Human HT-29 [ 27, eetrTp utp pce otPoutN.Ligand No. Product Host Species AminoAcids Excitatory Subtype Receptor Type Ligand No. Product Host Species Cytokines Subtype Receptor Type Ligand No. Product Host Species G Protein-CoupledReceptors Subtype Receptor Type Order Online: For country-specific orderinginformation,visit www.perkinelmer.com/lasoffices orseepage4 Order byPhone: lndRcpo ebaePeaain NENRadioligands NENRadioligands Cloned ReceptorMembranePreparations Cloned ReceptorMembranePreparations NENRadioligands Cloned ReceptorMembranePreparations V V V Please inquire for receptor availability. receptor for availability. inquire Please receptor for inquire Please Please inquire for receptor availability. receptor for inquire Please Please inquire for receptor availability. receptor for inquire Please availability. receptor for inquire Please 2 1B 1B 1A 2 ua H 10401TVspesn -riie noeosNET800 NET800 Endogenous Endogenous [phenylalanyl-3,4,5- 8-arginine, 6110541001KT Vasopressin, 6110543001KT 8-arginine, Vasopressin, RBHV1BM400UA CHO Human CHO Human HEK293 Human Vasopressin RBHV1AM400UA (linear) UrotensinII(Tyr V RBMUR2M100UA Human HEK293 CHO Mouse www.perkinelmer.com/online 1-800-762-4000 or203-925-4600 RBMUR2M400UA Tyr aorsi,8agnn,Edgnu NET800 Endogenous 8-arginine, Vasopressin, antagonist (phenylacetyl [phenylalanyl-3,4,5- [phenylalanyl-3,4,5- mn--yrx--ehlsxzl-AP gns NET833 [vinylidene- Kainic acid, DL- 4-propionic acid, AMPA agonist Amino-3-hydroxy-5-methylisoxazole- tyhie [benzene-ring- Strychnine, D-[ Serine, L-[3,4- Glutamic acid, [propyl-2,3, CGP 39653, D-[2,3- Aspartic acid, [ Leptin, [ Leptin, [ Interleukin-6, Interleukin-1 C,N(-2tinlccoey)3 o-opttv NET886 Non-competitive [piperidyl-3,4- 4-piperidine, N-(1-(2 thienyl)cyclohexyl)-3, TCP, nelui-,[ Interleukin-2, AG [glutamate-3,4- NAAG, (+)-[3- MK-801, fnrdl [phenyl- Ifenprodil, satv netnlPlppie [ asoactive IntestinalPolypeptide, 2 Arg , 125 125 6,8 ,Tyr 3 ],(uie eobnn)ORaoit NEX340 recombinant)ObR (murine, I]-, agonist endogenous I]- ObR, NEX347 ()-Gyie noeosNET1092 endogenous Glycine, H(G)]- 125 β ,[ 125 125 9 ] AA,endogenous I]- PACAP, NEX294 9 ,[ ), 125 ,[ ), 3 ] EndogenousNEX269 EndogenousNEX229 I]- I]- H]- Non-competitive NET972 125 3 I]- Endogenous NEX232 125 ] MA polyamine H]- NMDA, NET1089 site 3 3 3 I]- H(N)]- H(N)]- H(N)]- α 1A ],(ua)Edgnu NEX379 Endogenous (human) I]-, 3 3 ] saaaeaoitNET581 Asparatateagonist H]- H]- Endogenous NET490 -[5-methyl- 3 3 H]- 1 H]- Kainate agonist NET875 3 ,-O-Me-D- H]- NMDA antagonist NET1050 3 ] lcn naoit NET773 Glycineantagonist H]- 3 H(N)]- Glutamate antagonist 125 3 H]- ] VIPNEX192 I]- ltmt,endogenous Glutamate, V NMDA antagonist Pharmacological Action Pharmacological Action Pharmacological Action 1A antagonist NEX310 NET1082 Product No. Product No. Product No. Receptor-Ligand Reference Guide Appendix 347 NET925 NEX413 Product No. 2 β 4 α Ion Channels agonist antagonistantagonist NET1030 NET1011 3 3 antagonist and autonomic ganglion Photoaffinity antagonist and autonomic ganglion agonist agonist Pharmacological Action Pharmacological H]- CNS, skeletal muscle NET1102 3 H]- antagonist L-Type NET847 I]- N-Type antagonistNEX239 I]- N-Type H]- L-Type antagonistNET863 H]- L-Type 3 3 I]- Neuromuscular NEX126 125 H]- CNS agonist NET827 agonist H]- CNS H]- Central antagonist NET757 antagonist H]- Central 3 H]- GABA-A antagonist NET946 antagonist H]- GABA-A 3 H]- L-Type antagonist NET741 antagonist H]- L-Type H]- 5-HT 125 H]- GABA-A agonist NET567 agonist H]- GABA-A H]- Peripheral agonist NET704 agonist H]- Peripheral ), [ 3 I]- Antagonist NEX242 I]- Antagonist I]- Non-L-Type antagonist NEX323 antagonist I]- Non-L-Type 3 H]- ERG antagonist NET1140 antagonist H]- ERG 3 -benzoate, Activator NET876 3 3 H]- 5-HT H]- Peripheral antagonist NET885 antagonist H]- Peripheral I]-IPH) CNS, skeletal muscleNEX358 I]-IPH) CNS, skeletal 3 22 3 3 ), [ α 125 125 125 H]- GABA-A agonist NET564 agonist H]- GABA-A 54 H]- I]- ERG antagonist NEX412 antagonist I]- ERG 3 H(N)]- CNS agonist NET1054 agonist H(N)]- CNS 3 H(N)]- Ryanodine NET950 H(N)]- Ryanodine ), [ 3 3 2 H]- agonist Vanilloid NET1132 H(N)]- antagonist 125 3 3 I]-, ([ H(N)]- 3 H]- ), [ -NH I]- Neuronal CNS I]- Neuronal 3 125 H(N)]- 11 -ol-20-one, GABA-A, modulator NET1047 18 3 H]- 125 3 α - [9,11,12- -Conotoxin MVIIC, [ -Conotoxin GVIA (Tyr -Bungarotoxin (Tyr α 5 Cytisine HCl, [3,5- [cyclohexyl-2,3- Diltiazem, cis-(+)-[N-methyl- Nitrendipine, [5-methyl- Ryanodine, [9,21- SR 95531, [butyryl-2,3- Pregnan-3 PK 11195, [N-methyl- ω PN 200-110, (+)-[5-methyl- (+/-)-Epibatidine, [5,6-bicycloheptyl- RO 15-1788, [N-methyl- Sodium-22 radionuclideResiniferatoxin, [ Sodium flux NEZ081 [N-methyl- A-85380, [ α Nicotine, L-(-)-[N-methyl- Apamin (His Rubidium-86 radionuclideAstemizole, [O-methyl- Potassium fluxBatrachotoxinin A 20- NEZ072 Diazepam, [methyl- RO 5-4864, [N-methyl- RO 15-4513, [7,9- Calcium-45 ω n/a NEZ013 Muscimol, 3-hydroxy-5- GABA-A agonist NET574 agonist Muscimol, GABA-A 3-hydroxy-5- aminomethylisoxazole, [methylene- Verapamil hydrochloride,Verapamil antagonist L-Type NET810 Receptor-Ligand Reference Guide Reference Receptor-Ligand RBHS3M400UA GR 65630, [N-methyl- [email protected] www.perkinelmer.com/reagents Human HEK293Human HEK293 RBHERGM400UA BeKm-1 (Tyr RBHS3M100UA BRL-43694, [9-methyl- 3 Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. K+ channel Please inquire for receptor availability. Please inquire for receptor availability. Cloned Receptor Membrane PreparationsCloned Receptor NEN Radioligands Cholinergic Nicotinic* Human IMR32 RBHNICM400UA Epibatidine, [ Channel Glibenclamide, glyburide, NET1024 ATP-dependent Calcium (GABA-A) Flunitrazepam,(GABA-A) [methyl- Vanilloid Serotonin 5-HT Nicotinic Sodium hERG Channel [benzoyl-2,5- Channel (Acetylcholine) Potassium Receptor Type Subtype Species Host Product No. Ligand Ion Channels Benzodiazepine Customer Support e-mail: [email protected] Support e-mail: [email protected], Technical Visit our website at Appendix Receptor-Ligand Reference Guide 348 Sigma/Signal Transduction Receptor-Ligand Reference Guide Phospholipase Nitric Oxide Inositol rpopaeD-[inositol-1- triphosphate Fatty acid Sphingomyelenase Nnoit)DG(,-iotllundn,Sga NET986 Sigma DTG(1,3-di-o-tolylguanidine, (Non-opiate) eetrTp utp pce otPoutN.Ligand No. Product Host Species Signal Transduction Subtype Receptor Type Ligand No. Product Host Species Sigma Sigma Subtype Receptor Type Order Online: For country-specific orderinginformation,visit www.perkinelmer.com/lasoffices orseepage4 Order byPhone: lndRcpo ebaePeaain NENRadioligands NENRadioligands Cloned ReceptorMembranePreparations Cloned ReceptorMembranePreparations Please inquire for receptor availability. receptor for inquire Please Please inquire for receptor availability. receptor for inquire Please availability. receptor for inquire Please availability. receptor for inquire Please availability. receptor for inquire Please availability. receptor for inquire Please www.perkinelmer.com/online 1-800-762-4000 or203-925-4600 hshtdlnstl45bshsht,PC noeos NET895 endogenous PLC, Phosphatidylinositol 4,5-bisphosphate, riiemnhdohoie O usrt NET1123 NOSsubstrate EndogenousNET911 L-[2,3,4- NET941 Arginine monohydrochloride, D-[inositol-1- Inositol-1,4,5-trisphosphate, Endogenous Inositol-1,3,4,5-tetrakisphosphate, yitcai,[9,10- Myristic acid, Sphingomyelin [cholinemethyl- [inositol-2- [1- endogenousNET1135 PLC, Phosphatidylinositol-4,5-bisphosphate, [p-ring- fnrdl [phenyl- Ifenprodil, [ring-1,3- (+)-Pentazocine, 3 ],(inositol-1- H]-, 3 ]) [5- H]-), 3 H]- 3 ()- (PIP2) H(N)]-, 3 3 H(N)]- H(N)]- 3 H(N)]- 3 3 ] im,NMDA H]- Sigma, NET1089 H) 3 H(N)]- Endogenous NET830 substrate 3 ] im NET1056 H]- Sigma 3 ],SphingomyelenaseNET1134 H]-, Pharmacological Action Pharmacological Action substrate Product No. Product No. Receptor-Ligand Reference Guide Appendix 349 Product No. NLP004 NET590 Steroids PR Photoaffinity agonist AR photoaffinity agonist Pharmacological Action Pharmacological H]- VDR,NET626 endogenous 3 H]- H]- Endogenous NET349 3 H(N)]- Ecdysteroid agonist NET1070 H(N)]- Ecdysteroid 3 H(N)]- AR, endogenous NET553 I]- THR, endogenous NEX109 3 H]- Photoaffinity agonist NET555 agonist H]- Photoaffinity 3 I]-I]-I]- THR, endogenous NEX110 THR, endogenous THR, endogenous NEX110H NEX110X 3 125 H]- AR agonist NET919 H]- AR 125 125 125 H(N)]- ER, endogenous NET517 H(N)]-, GR, endogenous NET396 3 I]iodo- ER, endogenous NEX144L I]iodo- ER, endogenous NEX144 H(N)]- GR, endogenous NET399 H(N)]- GR, endogenous 3 H(N)]- MR, endogenous NET419 H(N)]- MR, endogenous 3 3 3 H(N)]- PR, endogenous NET381 H(N)]- PR, endogenous H(N)]- AR, endogenous NET370 H(N)]- AR, endogenous 3 H(N)]- GR agonist NET467 H(N)]- GR , 25-[26,27- 125 125 3 -methyl- 3 H(N)]- Ecdysteroid agonist NET621 agonist H(N)]- Ecdysteroid -[ -[ α 3 α -methyl- H(N)]- ER, endogenous NET317 H(N)]- ER, endogenous α α -OL-3-one), H(N)]-) α ,1 3 3 , 25-[26,27- 3 β I]-I]-I]- THR, endogenous NEX111 THR, endogenous NEX111H THR, endogenous NEX111X -methyl- 3 α H(N)]- 125 125 125 3 H(N)]- -D-glucuronide, ER, endogenous NET1106 3 -[23,24- β α -Estradiol, 16 -Estradiol, 16 β β androstan-17 α Promegestone, [17 Testosterone, [1,2,6,7- Thyroxine, L-, [ Triiodothyronine, L-3,3',5', [ Hydrocortisone, [1,2,6,7- Triiodothyronine, L-3,5,3'-[ 3,17 Dexamethasone, [6,7- (Cortisol, [1,2,6,7- Progesterone, [1,2,6,7- Promegestone, (R5020) Thyroxine, L-, [ Triiodothyronine, L-3,5,3'-[ Dihydroxyvitamin D Hydroxyvitamin D Mibolerone AR agonist NLP024 NET453 Aldosterone, D-[1,2,6,7- agonist AR,Dihydrotestosterone endogenous (5 [1,2,4,5,6,7- AR Mibolerone Mibolerone, [17 Ecdysone, Ponasterone A, [24,25,26,27- Estradiol, [2,4,6,7,16,17- 3,17 Corticosterone, [1,2,6,7- Triiodothyronine, L-3,5,3'-[ Estradiol, [2,4,6,7- Estradiol 17 [Estradiol-6,7- Testosterone, [1,2,6,7,16,17- Methyltrienolone (R1881) Methyltrienolone, [17 AR agonist NLP005 Receptor-Ligand Reference Guide Reference Receptor-Ligand [email protected] www.perkinelmer.com/reagents Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptorPlease inquireavailability. for receptor availability. Cloned Receptor Membrane PreparationsCloned Receptor NEN Radioligands 3 Steroids Receptor Type Subtype Species Host Product No. Ligand Ecdesteroid Androgen Hormones Thyroxine, L-, [ Thyroid Glucocorticoid Progestin Aldosterone Vitamin D Estrogen Customer Support e-mail: [email protected] Support e-mail: [email protected], Technical Visit our website at Appendix Receptor-Ligand Reference Guide 350 Transporters Receptor-Ligand Reference Guide eetrTp utp pce otPoutN.Ligand No. Product Host Species Transporters Subtype Receptor Type Norepinephrine Acetylcholine Transferrin Dopamine eooi eooi ua HK9 RHT10A iaorm [N-methyl- Citalopram, RBHSTM100UA HEK293 SerotoninHuman Serotonin Order Online: For country-specific orderinginformation,visit www.perkinelmer.com/lasoffices orseepage4 Order byPhone: lndRcpo ebaePeaain NENRadioligands Cloned ReceptorMembranePreparations Please inquire for receptor availability. receptor for inquire Please Norepinephrine Dopamine availability. receptor for inquire Please ua DKRHEM0U Dsehlmpaiehdohoie paeihbtr NET593 Uptake Desmethylimipramine RBHNETM100UA inhibitor hydrochloride, Human MDCK RBHDATM100UA [ RTI-121, Human CHO www.perkinelmer.com/online 1-800-762-4000 or203-925-4600 BNT40A[ezn ig 10,11- [benzenering, RBHNETM400UA BDT40ARI5,[ RBHDATM400UA RTI-55, BSM0U mpaiehdohoie paeihbtr NET576 Uptakeinhibitor Imipraminehydrochloride, RBHSTM400UA ehl4peyprdnu ctt,Utk niio NET914 Uptakeinhibitor [N-methyl- Methyl-4-phenylpyridinium acetate, ioeiehdohoie paeihbtr NET1084 Uptakeinhibitor [N-methyl- Nisoxetine hydrochloride, levo-[benzoyl-3,4- Cocaine, NET884 Uptakeinhibitor [methyl- diacetatesalt, Hemicholinium-3, rnfri,[ Transferrin, [phenyl-6'- Paroxetine, [benzene ring- I 52,[N-methyl- WIN 35428, B 23,[propylene-2,3- GBR 12935, aidl [4'- Mazindol, 3 125 H]- 125 3 3 I]- Uptake inhibitor NEX272 H]- (MPP(+)) H]-, 125 I]- Uptake inhibitor NEX318 3 3 H]- Uptake inhibitor NET816 ],dfri,(ua)EndogenousNEX212 (human) diferric, I]-, H(N)]- 3 3 H]- 3 3 H]- Uptake inhibitor NET1039 H]- Uptake NET869 inhibitor H]- Uptake inhibitor NET1033 3 H(N)]- Uptake NET510 inhibitor 3 ] paeihbtrNET918 Uptakeinhibitor H]- Pharmacological Action Product No. Receptor-Ligand Reference Guide Appendix 351 Product No. ed outside of the n (“Licensed Customers”). Pharmacological Action Pharmacological I]- Endogenous NEX268 125 I]- Endogenous NEX241 1, Endogenous NEX267 I]- Endogenous NEX257 I]-, Endogenous NEX160 125 β 125 Tyrosine Kinase Receptors Kinase Tyrosine 125 ,[ α I]- I]-, (human) Endogenous NEX100 125 125 I]-, Endogenous NEX196 125 ), [ I]-, (porcine) Endogenous NEX104 I]-, (porcine) Endogenous A14 125 I]-EGF), (murine) I]- I]- 125 125 125 Insulin (Tyr Insulin, [ receptor grade, (porcine) Fibroblast Growth Factor Basic, [ Granulocyte Macrophage-ColonyStimulating Factor, [ EndogenousGrowth Hormone, [ Insulin-like Growth Factor-I, [ NEX249 Growth Factor Transforming Necrosis Factor- Tumor Endothelial Growth Factor,Vascular Endogenous NEX328 Receptor-Ligand Reference Guide Reference Receptor-Ligand [email protected] www.perkinelmer.com/reagents Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptorPlease inquireavailability. for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. Please inquire for receptor availability. Cloned Receptor Membrane PreparationsCloned Receptor NEN Radioligands United States AND whose principal place of business is in such territory of incorporation. For sales outside of the United States: These products can ONLY be sold to Licensed Customers or to customers who are incorporat Fibroblast Insulin-like Growth Factor Insulin Growth Factor Necrosis Tumor Factor Vascular [ Growth Hormone Growth Factor Transforming Macrophage-Colony Stimulating Factor Growth FactorGrowth Factor Granulocyte ([ Endothelial [ Endothelial Epidermal EGF* Human A-431 RBHEGFM400UA Epidermal Growth Factor, [ Tyrosine Kinase Receptors Kinase Tyrosine Receptor Type Subtype Species Host Product No. Ligand ** For sales in the United States: These products can ONLY be sold to customers who hold a license from the University of Michiga * Non-recombinant Customer Support e-mail: [email protected] Support e-mail: [email protected], Technical Visit our website at Key: Notes 352 Notes Order Online: For country-specific orderinginformation,visit www.perkinelmer.com/lasoffices orseepage4 Order byPhone: www.perkinelmer.com/online 1-800-762-4000 or203-925-4600