JOURNAL OF Volume 61 April 1987 No. 4

ANIMAL A Bicistronic Epstein-Barr mRNA Encodes Two Nuclear in Latently Infected, Growth-Transformed Lymphocytes. Fred Wang, Lisa Petti, Daniel Braun, Steven Seung, and Elliott Kieff ...... 945-954 Site-Specific Antibodies Define a Cleavage Site Conserved among Arenavirus GP-C Glycoproteins. M. J. Buchmeier, P. J. Southern, B. S. Parekh, M. K. Wooddell, and M. B. A. Oldstone ...... 982-985 Characterization and Nucleotide Sequence of Two Virus 1 Genes Whose Products Modulate a-trans-Inducing Factor-Dependent Activation of at Genes. Jennifer L. C. McKnight, Phillip E. Pellett, Frank J. Jenkins, and Bernard Roizman ...... 992-1001 Molecular Epizootiology and Evolution of Vesicular Stomatitis Virus New Jersey. Stuart T. Nichol ...... 1029-1036 Transformation of Human Fibroblasts and Keratinocytes with Human Papilloma- virus Type 16 DNA. Lucia Pirisi, Shigeru Yasumoto, Martha Feller, Jay Doniger, and Joseph A. DiPaolo ...... 1061-1066 Mutants Defective in Type 2 ICP4: Isolation and Prelimi- nary Characterization. Colton A. Smith and Priscilla A. Schaffer ...... 1092-1097 Effects of a Temperature-Sensitive Mutation in the Immediate-Early Gene of Pseudorabies Virus on Class II and Class III Gene . Suzanne E. Ahlers and Lawrence T. Feldman ...... 1103-1107 Murine Cells Carrying Integrated Tandem of DNA Transcribe RNAs from Endogenous Promoters on Both Viral Strands and Express Middle and Major Proteins. Arthur Z. Zelent, Mary Ann Sells, Peter M. Price, Adel Mohamad, George Acs, and Judith K. Christman ...... 1108-1115 Chemical and Immunological Characterization of Equine Infectious Anemia Virus gag-Encoded Proteins. L. E. Henderson, R. C. Sowder, G. W. Smythers, and S. Oroszlan ...... 1116-1124 Expression of Herpes Simplex Virus Type 1 Major DNA-Binding , ICP8, in Transformed Cell Lines: Complementation of Deletion Mutants and Inhibi- tion of Wild-Type Virus. Paulo K. Orberg and Priscilla A. Schaffer ...... 1136-1146 Phosphorylation of Polyomavirus Large T Antigen: Effects of Viral Mutations and Cell Growth State. Beverly J. Bockus and Brian Schaffhausen ...... 1147-1154 Localization of the Phosphorylations of Polyomavirus Large T Antigen. Beverly J. Bockus and Brian Schaffhausen ...... 1155-1163 Characterization of Sequences Essential for Viral Gene Expression. Pamela A. Norton and John M. Coffin ...... 1171-1179 Transition from a Heterozygous to a Homozygous State of a Pair of Loci in the Inverted Repeat Sequences of the L Component of the Herpes Simplex Virus Type 1 . Kenichi Umene ...... 1187-1192 Abundant Expression of Polyomavirus Middle T Antigen and Dihydrofolate Reductase in an Adenovirus Recombinant. Kathleen L. Berkner, Brian S. Schaffhausen, Thomas M. Roberts, and Phillip A. Sharp ...... 1213-1220 Continued on following page Characterization of Middle T Antigen Expressed by Using an Adenovirus Expres- sion System. Brian S. Schaffhausen, Beverly J. Bockus, Kathleen L. Berkner, David Kaplan, and Thomas M. Roberts ...... 1221-1225 Overproduction of Polyomavirus Middle T Antigen in Mammalian Cells through the Use of an Adenovirus Vector. Dominique Davidson and John A. Hassell ...... 1226-1239 Mutational Analysis of Open Reading Frame E4 of Bovine Papillomavirus Type 1. Kathryn Neary, Bruce H. Horwitz, and Daniel DiMaio ...... 1248-1252 Methylation as a Modulator of Expression of Human Immunodeficiency Virus. Daniel P. Bednarik, Joseph D. Mosca, and N. B. K. Raj ...... 1253-1257 Immediate- of Pseudorabies Virus Is Not Continuously Required To Reinitiate Transcription of Induced Genes. Suzanne E. Ahlers and Lawrence T. Feldman...... 1258-1260 The 3' Long Terminal Repeat of a Transcribed yet Defective Endogenous Retroviral Sequence Is a Competent Promoter of Transcription. David E. Levy, Randall D. McKinnon, Mark N. Brolaski, James W. Gautsch, and Michael C. Wilson...... 1261-1265 Expression of the Rous Sarcoma Virus Gene from a Simian Virus 40 Late-Region Replacement Vector: Effects of Upstream Initiation Codons. Lautaro Perez, John W. Wills, and Eric Hunter...... 1276-1281 Isolation and Characterization of Phosphonoacetic Acid-Resistant Mutants of Human Cytomegalovirus. Richard T. D'Aquila and William C. Summers 1291-1295 VIRUS-CELL INTERACTIONS Structural and Transcriptional Analysis of Human Papillomavirus Type 16 Sequences in Cervical Carcinoma Cell Lines. Carl C. Baker, William C. Phelps, Valerie Lindgren, Michael J. Braun, Matthew A. Gonda, and Peter M. Howley ...... 962-971 Replication of Adeno-Associated Virus in Synchronized Cells without the Addition of a Helper Virus. Bracha Yakobson, Tamar Koch, and Ernest Winocour 972-981 Proteolysis of the p220 Component of the Cap-Binding Protein Complex Is Not Sufficient for Complete Inhibition of Host Cell Protein Synthesis after Poliovirus Infection. Anne-Marie Bonneau and Nahum Sonenberg ...... 986-991 Modification of RNA Polymerase 110 Subspecies after Poliovirus Infection. Luz Maria Rangel, Carlos Fernandez-Tomas, Michael E. Dahmus, and Patricio Gariglio ...... 1002-1006 Alterations in Nuclear Matrix Structure after Adenovirus Infection. Zhai Zhonghe, Jeffrey A. Nickerson, Gabriela Krochmalnic, and Sheldon Penman ...... 1007-1018 Myristylation Is Required for Intracellular Transport but Not for Assembly of D-Type . Sung S. Rhee and Eric Hunter ...... 1045-1053 Correlation of Leukemogenic Potential of Murine with Transcrip- tional Tissue Preference of the Viral Long Terminal Repeats. Mary K. Short, Sharon A. Okenquist, and Jack Lenz...... 1067-1072 Activation of int-I and int-2 Mammary Oncogenes in Hormone-Dependent and -Independent Mammary Tumors of GR Mice. J. Mester, E. Wagenaar, M. Sluyser, and R. Nusse ...... 1073-1078 Analysis of Polyomavirus Middle-T-Antigen-Transformed Rat Cell Variants Expressing Different Levels of pp6Oc-src. Joseph B. Bolen, Shohreh Amini, Virginia DeSeau, Sita Reddy, and David Shalloway ...... 1079-1085

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Dsi-1, a Region with Frequent Proviral Insertions in Moloney -Induced Rat Thymomas. S. Vijaya, D. L. Steffen, C. Kozak, and H. L. Robinson ...... 1164-1170 Integration of Hepatitis B Virus: Analysis of Unoccupied Sites. Itzhak Berger and Yosef Shaul...... 1180-1186 Complete Interaction of Cellular 56,000- and 32,000-Mr Proteins with Simian Virus 40 Small-t Antigen in Productively Infected Cells. Kathleen Rundell 1240-1243 Deletion Mutations in the Small t Antigen Gene Alter the Tissue Specificity of Tumors Induced by Simian Virus 40. Betty-Jean Matthews, Arthur S. Levine, and Kathleen Dixon...... 1282-1285 trans-Activation of Cellular and Viral Promoters by a Transforming Nonkaryo- philic Simian Virus 40 Large T Antigen. Antonio Pannuti, Anna Pascucci, Girolama La Mantia, Lia Fisher-Fantuzzi, Cesare Vesco, and Luigi Lania 1296-1299 VIRAL PATHOGENESIS AND IMMUNITY In Vivo Phosphorylation and Protein Analysis of Hepatitis B Virus Core Antigen. Marilyn J. Roossinck and Aleem Siddiqui ...... 955-961 Topographical Rearrangements of Visna Virus Envelope Glycoprotein during Antigenic Drift. Jeff Stanley, Leena M. Bhaduri, Opendra Narayan, and Janice E. Clements ...... 1019-1028 Horizontal Transmission of Murine Retroviruses. John L. Portis, Frank J. McAtee, and Stanley F. Hayes...... 1037-1044 Virus Recombinants Expressing the SA1l VP7 Glycoprotein Gene Induce Serotype-Specific Neutralizing Antibodies. Marion E. Andrew, David B. Boyle, Barbara E. H. Coupar, Peter L. Whitfeld, Gerald W. Both, and A. Richard Bellamy ...... 1054-1060 Analysis of Mixed Infection of Sheep with Bluetongue Virus Serotypes 10 and 17: Evidence for Genetic Reassortment in the Vertebrate Host. Siba K. Samal, Charles W. Livingston, Jr., Stewart McConnell, and Robert F. Ramig .... 1086-1091 Anti- Virus Cytotoxic T Lymphocytes Recognize the Three Viral Poly- merases and a Nonstructural Protein: Responsiveness to Individual Viral Antigens Is Major Histocompatibility Complex Controlled. Jack R. Bennink, Jonathan W. Yewdell, G. L. Smith, and B. Moss ...... 1098-1102 Antigenic Cross-Reactions among Herpes Simplex Virus Types 1 and 2, Epstein-Barr Virus, and Cytomegalovirus. N. Balachandran, Douglas E. Oba, and Lindsey M. Hutt-Fletcher ...... 1125-1135 Nucleic Acid Sequence and Oncogenic Properties of the HZ2 Feline Sarcoma Virus v-abl Insert. P. J. Bergold, J. A. Blumenthal, E. D'Andrea, H. W. Snyder, L. Lederman, A. Silverstone, H. Nguyen, and P. Besmer...... 1193-1202 Genetic Determinants of Neoplastic Diseases Induced by a Subgroup F Avian Leukosis Virus. M. Celeste Simon, Wendi S. Neckameyer, William S. Hayward, and Ralph E. Smith ...... 1203-1212 Infection of Brain-Derived Cells with the Human Immunodeficiency Virus. F. Chiodi, S. Fuerstenberg, M. Gidlund, B. Asjo, and E. M. Fenyo ...... 1244-1247 Course and Extent of Variation of Equine Infectious Anemia Virus during Parallel Persistent Infections. Susan L. Payne, Olivia Salinovich, Ronald C. Montelaro, Charles J. Issel, and Suzanne M. Nauman ...... 1266-1270 Mapping and Sequencing of a Gene from Myxoma Virus That Is Related to Those Encoding Epidermal Growth Factor and Transforming Growth Factor Alpha. Chris Upton, Joanne L. Macen, and Grant McFadden...... 1271-1275 Selective Synthesis and Secretion of Particles Composed of the Hepatitis B Virus Middle Surface Protein Directed by a Recombinant Vaccinia Virus: Induction of Antibodies to Pre-S and S Epitopes. Kuo-Chi Cheng and Bernard Moss 1286-1290

Date of Issue: 10 March 1987