LSD Modulates Music-Induced Imagery Via Changes in Parahippocampal Connectivity
European Neuropsychopharmacology (2016) 26, 1099–1109 www.elsevier.com/locate/euroneuro LSD modulates music-induced imagery via changes in parahippocampal connectivity Mendel Kaelena,n, Leor Rosemana,b, Joshua Kahanc, Andre Santos-Ribeiroa, Csaba Orbana, Romy Lorenzb, Frederick S. Barrettd, Mark Bolstridgea, Tim Williamse, Luke Williamsa, Matthew B. Walla,f,g, Amanda Feildingh, Suresh Muthukumaraswamyi, David J. Nutta, Robin Carhart-Harrisa aCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London W12, UK bThe Computational, Cognitive and Clinical Neuroimaging Laboratory, The Centre for Neuroscience, Division of Brain Sciences, Imperial College London, London W12, UK cSobell Department of Motor Neuroscience & Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK dBehavioral Pharmacology Research Unit, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA eAcademic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, UK fImanova Centre for Imaging Sciences, Hammersmith Hospital, London W12, UK gClinical Psychopharmacology Unit, University College London, London UK hThe Beckley Foundation, Beckley Park, Oxford OX3 9SY, UK iSchools of Pharmacy and Psychology, University of Auckland, Auckland 1142, New Zealand Received 10 November 2015; received in revised form 15 February 2016; accepted 24 March 2016 KEYWORDS Abstract Effective connectiv- Psychedelic drugs such as lysergic acid diethylamide (LSD) were used extensively in psychiatry ity; in the past and their therapeutic potential is beginning to be re-examined today. Psychedelic LSD; psychotherapy typically involves a patient lying with their eyes-closed during peak drug effects, Mental imagery; while listening to music and being supervised by trained psychotherapists. In this context, music Music; is considered to be a key element in the therapeutic model; working in synergy with the drug to Parahippocampus; evoke therapeutically meaningful thoughts, emotions and imagery.
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