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Download Formulary ADHD/ANTI-NARCOLEPSY/ANTI-OBESITY/ANOREXIANTS ............................................................................................... 19 ADHD AGENT - SELECTIVE ALPHA ADRENERGIC AGONISTS .......................................................................................................... 19 ADHD AGENT - SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITOR ............................................................................................. 19 AMPHETAMINE MIXTURES ................................................................................................................................................................... 19 AMPHETAMINES................................................................................................................................................................................... 19 ANALEPTICS ........................................................................................................................................................................................ 19 ANOREXIANTS NON-AMPHETAMINE ................................................................................................................................................... 19 STIMULANTS - MISC. ........................................................................................................................................................................... 19 ALS AGENTS - MISCELLANEOUS ........................................................................................................................................... 19 ALS AGENTS - MISCELLANEOUS ....................................................................................................................................................... 19 AMINOGLYCOSIDES .................................................................................................................................................................. 19 AMINOGLYCOSIDES ............................................................................................................................................................................. 19 ANALGESICS - ANTI-INFLAMMATORY ................................................................................................................................... 19 ANTIRHEUMATIC - JANUS KINASE (JAK) INHIBITORS ....................................................................................................................... 19 ANTIRHEUMATIC ANTIMETABOLITES .................................................................................................................................................. 19 ANTI-TNF-ALPHA - MONOCLONAL ANTIBODIES ................................................................................................................................ 20 CYCLOOXYGENASE 2 (COX-2) INHIBITORS ....................................................................................................................................... 20 GOLD COMPOUNDS ............................................................................................................................................................................. 20 INTERLEUKIN-1 BLOCKERS ................................................................................................................................................................ 20 INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL-1RA) .......................................................................................................................... 20 INTERLEUKIN-1BETA BLOCKERS ........................................................................................................................................................ 20 INTERLEUKIN-6 RECEPTOR INHIBITORS ............................................................................................................................................. 20 NONSTEROIDAL ANTI-INFLAMMATORY AGENT COMBINATIONS ........................................................................................................ 20 NONSTEROIDAL ANTI-INFLAMMATORY AGENTS (NSAIDS) .............................................................................................................. 20 PHOSPHODIESTERASE 4 (PDE4) INHIBITORS .................................................................................................................................... 20 PYRIMIDINE SYNTHESIS INHIBITORS ................................................................................................................................................... 20 SELECTIVE COSTIMULATION MODULATORS ...................................................................................................................................... 20 SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR AGENTS .............................................................................................................. 20 ANALGESICS - NONNARCOTIC ............................................................................................................................................... 20 ANALGESICS OTHER ........................................................................................................................................................................... 20 ANALGESICS-SEDATIVES .................................................................................................................................................................... 20 SALICYLATE COMBINATIONS .............................................................................................................................................................. 20 SALICYLATES ...................................................................................................................................................................................... 20 SELECTIVE N-TYPE NEURONAL CALCIUM CHANNEL BLOCKERS ..................................................................................................... 21 ANALGESICS - OPIOID .............................................................................................................................................................. 21 CODEINE COMBINATIONS ................................................................................................................................................................... 21 DIHYDROCODEINE COMBINATIONS ..................................................................................................................................................... 21 HYDROCODONE COMBINATIONS......................................................................................................................................................... 21 OPIOID AGONISTS ............................................................................................................................................................................... 21 OPIOID COMBINATIONS ....................................................................................................................................................................... 21 OPIOID PARTIAL AGONISTS ................................................................................................................................................................ 21 TRAMADOL COMBINATIONS ................................................................................................................................................................ 21 ANDROGENS-ANABOLIC .......................................................................................................................................................... 21 ANDROGENS ........................................................................................................................................................................................ 21 ANORECTAL AGENTS ............................................................................................................................................................... 21 INTRARECTAL STEROIDS .................................................................................................................................................................... 21 Updated June 01, 2021 Page 1 NITRATE VASODILATING AGENTS ...................................................................................................................................................... 21 RECTAL ANESTHETIC/STEROIDS ........................................................................................................................................................ 22 ANTHELMINTICS ......................................................................................................................................................................... 22 ANTHELMINTICS .................................................................................................................................................................................. 22 ANTIANGINAL AGENTS ............................................................................................................................................................. 22 ANTIANGINALS-OTHER ....................................................................................................................................................................... 22 NITRATES ............................................................................................................................................................................................ 22 ANTIANXIETY
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  • Pitolisant (Wakix) Reference Number: CP.PMN.221 Effective Date: 03.01.20 Last Review Date: 02.21 Line of Business: Commercial, HIM, Medicaid Revision Log
    Clinical Policy: Pitolisant (Wakix) Reference Number: CP.PMN.221 Effective Date: 03.01.20 Last Review Date: 02.21 Line of Business: Commercial, HIM, Medicaid Revision Log See Important Reminder at the end of this policy for important regulatory and legal information. Description ® Wakix (pitolisant) is a selective histamine 3 (H3) receptor antagonist/inverse agonist. FDA Approved Indication(s) Wakix is indicated for the treatment of excessive daytime sleepiness (EDS) or cataplexy in adult patients with narcolepsy. Policy/Criteria Provider must submit documentation (such as office chart notes, lab results or other clinical information) supporting that member has met all approval criteria. It is the policy of health plans affiliated with Centene Corporation® that Wakix is medically necessary when the following criteria are met: I. Initial Approval Criteria A. Narcolepsy with Cataplexy (must meet all): 1. Diagnosis of narcolepsy with cataplexy; 2. Prescribed by or in consultation with a neurologist or sleep medicine specialist; 3. Age ≥ 18 years; 4. Failure of 2 of the following antidepressants, each used for ≥ 1 month, unless member’s age is ≥ 65, clinically significant adverse effects are experienced, or all are contraindicated: venlafaxine, fluoxetine, atomoxetine, clomipramine, protriptyline; 5. Dose does not exceed 35.6 mg (two 17.8 mg tablets) per day. Approval duration: Medicaid/HIM – 12 months Commercial – Length of Benefit B. Narcolepsy with Excessive Daytime Sleepiness (must meet all): 1. Diagnosis of narcolepsy with EDS; 2. Prescribed by or in consultation with a neurologist or sleep medicine specialist; 3. Age ≥ 18 years; 4. Failure of a 1-month trial of one of the following central nervous system (CNS) stimulants at up to maximally indicated doses, unless clinically significant adverse effects are experienced or all are contraindicated: amphetamine immediate-release (IR), amphetamine, dextroamphetamine IR, dextroamphetamine, methylphenidate IR; *Prior authorization may be required for CNS stimulants Page 1 of 6 CLINICAL POLICY Pitolisant 5.
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  • International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
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    medicines Review Pitolisant and Other Histamine-3 Receptor Antagonists—An Update on Therapeutic Potentials and Clinical Prospects Victoria Harwell and Pius S. Fasinu * Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27501, USA; [email protected] * Correspondence: [email protected] Received: 28 July 2020; Accepted: 27 August 2020; Published: 1 September 2020 Abstract: Background: Besides its well-known role as a peripheral chemical mediator of immune, vascular, and cellular responses, histamine plays major roles in the central nervous system, particularly in the mediation of arousal and cognition-enhancement. These central effects are mediated by the histamine-3 auto receptors, the modulation of which is thought to be beneficial for the treatment of disorders that impair cognition or manifest with excessive daytime sleepiness. Methods: A database search of PubMed, Google Scholar, and clinicaltrials.gov was performed in June 2020. Full-text articles were screened and reviewed to provide an update on pitolisant and other histamine-3 receptor antagonists. Results: A new class of drugs—histamine-3 receptor antagonists—has emerged with the approval of pitolisant for the treatment of narcolepsy with or without cataplexy. At the recommended dose, pitolisant is well tolerated and effective. It has also been evaluated for potential therapeutic benefit in Parkinson disease, epilepsy, attention deficit hyperactivity disorder, Alzheimer’s disease, and dementia. Limited
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    Neuropsychopharmacology (2004) 29, 705–717 & 2004 Nature Publishing Group All rights reserved 0893-133X/04 $25.00 www.neuropsychopharmacology.org Histamine H3 Receptor Antagonists Potentiate Methamphetamine Self-Administration and Methamphetamine-Induced Accumbal Dopamine Release 1,3,4 2,4 1,4 ,1 Patrik Munzar , Gianluigi Tanda , Zuzana Justinova and Steven R Goldberg* 1Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, Department of Health 2 and Human Services, Baltimore, MD, USA; Psychobiology Section, Medications Discovery Research Branch, Intramural Research Program, NIDA, NIH, Department of Health and Human Services, Baltimore, MD, USA Methamphetamine administration increases brain levels of histamine and neuronal histamine attenuates several of methamphetamine’s behavioral effects. The role of different subtypes of histamine receptors in this negative feedback, however, remains unclear. There is some evidence on possible involvement of histamine H3 receptors in these actions of methamphetamine. The aim of the present study was to evaluate the effects of two histamine H3 receptor antagonists, clobenpropit and thioperamide, on rewarding and neurochemical effects of methamphetamine utilizing three in vivo methodologies, drug self-administration, drug discrimination, and microdialysis in Sprague–Dawley rats. In rats self-administering methamphetamine intravenously under a fixed-ratio schedule, presession treatment with thioperamide (1.0–3.0 mg/kg, subcutaneous, s.c.) or clobenpropit (1.0–3.0 mg/kg, s.c.) potentiated the reinforcing effects of methamphetamine, as indicated by a dose-dependent increase in responding for a low 0.03 mg/kg dose of methamphetamine, that by itself failed to maintain responding above saline substitution levels, and a decrease in responding for a higher 0.06 mg/kg training dose of methamphetamine.
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  • Drug Monograph
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  • WAKIX Is Contraindicated in Patients with Severe Hepatic Impairment (4) WAKIX® Safely and Effectively
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