The Functional and Structural Neural Basis of Individual Differences in Loss Aversion
The Journal of Neuroscience, September 4, 2013 • 33(36):14307–14317 • 14307 Behavioral/Cognitive The Functional and Structural Neural Basis of Individual Differences in Loss Aversion Nicola Canessa,1,2,3,4,5 Chiara Crespi,1,2 Matteo Motterlini,1,2,5 Gabriel Baud-Bovy,1,6 Gabriele Chierchia,1,2 Giuseppe Pantaleo,1 Marco Tettamanti,2,7 and Stefano F. Cappa1,2,3,4,5 1Vita-Salute San Raffaele University, 20132 Milan, Italy, 2Center for Cognitive Neuroscience, Vita-Salute San Raffaele University, 20132 Milan, Italy, 3Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy, 4CERMAC, San Raffaele Scientific Institute, 20132 Milan, Italy, 5CRESA, Vita- Salute San Raffaele University, 20132 Milan, Italy, 6Robotics, Brain, and Cognitive Sciences Department, Istituto Italiano di Tecnologia, 16163 Genoa, Italy, and 7Nuclear Medicine Department, San Raffaele Scientific Institute, 20132 Milan, Italy Decision making under risk entails the anticipation of prospective outcomes, typically leading to the greater sensitivity to losses than gains known as loss aversion. Previous studies on the neural bases of choice-outcome anticipation and loss aversion provided inconsistent results, showing either bidirectional mesolimbic responses of activation for gains and deactivation for losses, or a specific amygdala involvement in processing losses. Here we focused on loss aversion with the aim to address interindividual differences in the neural bases of choice-outcome anticipation. Fifty-six healthy human participants accepted or rejected 104 mixed gambles offering equal (50%) chances of gaining or losing different amounts of money while their brain activity was measured with functional magnetic resonance imaging (fMRI). We report both bidirectional and gain/loss-specific responses while evaluating risky gambles, with amygdala and posterior insula specifically tracking the magnitude of potential losses.
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