Interactions Between Anti-Retroviral Drugs and Commonly Used Drugs in Anaesthesia and Other Procedures

Interactions between anti-retroviral drugs and commonly

used drugs in anaesthesia and other procedures

My anti-retroviral drugs may interact with some of the anaesthetics, sedatives or painkillers prescribed to me during, and following my admission for surgery or an endoscopy. Please see the table below for the drugs I am taking and any potential interactions. For information on any drugs not listed in the table and/or more data on the predicted impact of potential interactions, please refer to the Liverpool antiretroviral drug interactions checker via the following link: https://www.hiv-druginteractions.org/checker I am happy for you to contact my specialist, Dr.______for any further information on my condition and treatment or contact the out of hours HIV consultant via switchboard.

Key: ʘ do not co-administer (ʘ) potential weak interaction ʘ potential interaction ʘ no interaction

There are no known interactions between the anti-retroviral drugs listed and any of the following:

 Thiopental  Neostigmine  Isoflurane  Glycopyrrolate  Desflurane  Atropine  Cyclizine  Adrenaline  Vecuronium  Lorazepam

Propofol Ketamine Sevoflurane Midazolam Diazepam Abacavir ʘ ʘ ʘ ʘ ʘ Abacavir/lamivudine ʘ ʘ ʘ ʘ ʘ Atazanavir ʘ ʘ ʘ ʘ ʘ Atazanavir + ritonavir ʘ ʘ ʘ ʘ ʘ Biktarvy ʘ ʘ ʘ ʘ ʘ Darunavir + ritonavir ʘ ʘ ʘ ʘ ʘ Delstrigo ʘ ʘ ʘ ʘ ʘ Descovy ʘ ʘ ʘ ʘ ʘ Dolutegravir ʘ ʘ ʘ ʘ ʘ Doravirine ʘ ʘ ʘ ʘ ʘ Dovato ʘ ʘ ʘ ʘ ʘ Efavirenz ʘ ʘ ʘ ʘ ʘ Efavirenz/emtricitabine/tenofovir ʘ ʘ ʘ ʘ ʘ Emtricitabine ʘ ʘ ʘ ʘ ʘ Emtricitabine/tenofovir ʘ ʘ ʘ ʘ ʘ Etravirine ʘ ʘ ʘ ʘ ʘ Eviplera ʘ ʘ ʘ ʘ ʘ Evotaz ʘ ʘ ʘ ʘ ʘ Genvoya ʘ ʘ ʘ ʘ ʘ Juluca ʘ ʘ ʘ ʘ ʘ Lamivudine ʘ ʘ ʘ ʘ ʘ Nevirapine ʘ ʘ ʘ ʘ ʘ Odefsey ʘ ʘ ʘ ʘ ʘ Raltegravir ʘ ʘ ʘ ʘ ʘ Rezolsta ʘ ʘ ʘ ʘ ʘ Rilpivirine ʘ ʘ ʘ ʘ ʘ Stribild ʘ ʘ ʘ ʘ ʘ Symtuza ʘ ʘ ʘ ʘ ʘ Tenofovir ʘ ʘ ʘ ʘ ʘ Triumeq ʘ ʘ ʘ ʘ ʘ Zidovudine ʘ ʘ ʘ ʘ ʘ Zidovudine/lamivudine ʘ ʘ ʘ ʘ ʘ

www.westsussexsexualhealth.nhs.uk Department: Sexual Health Issue date: May 2020 Review date: May 2022 Author: Dr William Spice Version: V2

Morphine Fentanyl Tramadol Oxycodone Ondansetron Abacavir ʘ ʘ ʘ ʘ ʘ Abacavir/lamivudine ʘ ʘ ʘ ʘ ʘ Atazanavir ʘ ʘ (ʘ) ʘ ʘ Atazanavir + ritonavir ʘ ʘ (ʘ) ʘ ʘ Biktarvy ʘ ʘ ʘ ʘ ʘ Darunavir + ritonavir ʘ ʘ (ʘ) ʘ (ʘ) Delstrigo ʘ ʘ ʘ ʘ ʘ Descovy ʘ ʘ ʘ ʘ ʘ Dolutegravir ʘ ʘ ʘ ʘ ʘ Doravirine ʘ ʘ ʘ ʘ ʘ Dovato ʘ ʘ ʘ ʘ ʘ Efavirenz ʘ ʘ (ʘ) ʘ ʘ Efavirenz/emtricitabine/ ʘ ʘ (ʘ) ʘ ʘ tenofovir Emtricitabine ʘ ʘ ʘ ʘ ʘ Emtricitabine/tenofovir ʘ ʘ ʘ ʘ ʘ Etravirine (ʘ) ʘ ʘ ʘ ʘ Eviplera ʘ ʘ ʘ ʘ ʘ Evotaz ʘ ʘ (ʘ) ʘ ʘ Genvoya ʘ ʘ (ʘ) ʘ (ʘ) Juluca ʘ ʘ ʘ ʘ ʘ Lamivudine ʘ ʘ ʘ ʘ ʘ Nevirapine ʘ ʘ (ʘ) ʘ ʘ Odefsey ʘ ʘ ʘ ʘ ʘ Raltegravir ʘ ʘ ʘ ʘ ʘ Rezolsta ʘ ʘ (ʘ) ʘ (ʘ) Rilpivirine ʘ ʘ ʘ ʘ ʘ Stribild ʘ ʘ (ʘ) ʘ (ʘ) Symtuza ʘ ʘ (ʘ) ʘ (ʘ) Tenofovir ʘ ʘ ʘ ʘ ʘ Triumeq ʘ ʘ ʘ ʘ ʘ Zidovudine ʘ ʘ ʘ ʘ ʘ Zidovudine/lamivudine ʘ ʘ ʘ ʘ ʘ

Prochlorperazine Lidocaine Rocuronium Ephedrine Magnesium Abacavir ʘ ʘ ʘ ʘ ʘ Abacavir/lamivudine ʘ ʘ ʘ (ʘ) ʘ Atazanavir ʘ ʘ ʘ ʘ ʘ Atazanavir + ritonavir ʘ ʘ ʘ ʘ ʘ Biktarvy ʘ ʘ ʘ ʘ ʘ Darunavir + ritonavir (ʘ) ʘ ʘ ʘ ʘ Delstrigo ʘ ʘ ʘ (ʘ) ʘ Descovy ʘ ʘ ʘ ʘ ʘ Dolutegravir ʘ ʘ ʘ ʘ ʘ Doravirine ʘ ʘ ʘ ʘ ʘ Dovato ʘ ʘ ʘ ʘ ʘ Efavirenz ʘ (ʘ) ʘ ʘ ʘ Efavirenz/emtricitabine/ ʘ ʘ ʘ ʘ ʘ tenofovir Emtricitabine ʘ ʘ ʘ ʘ ʘ Emtricitabine/tenofovir ʘ ʘ ʘ ʘ ʘ Etravirine ʘ ʘ ʘ ʘ ʘ Eviplera (ʘ) ʘ ʘ ʘ ʘ Evotaz ʘ ʘ ʘ ʘ ʘ Genvoya (ʘ) ʘ ʘ ʘ ʘ Juluca (ʘ) ʘ ʘ ʘ ʘ Lamivudine ʘ ʘ ʘ (ʘ) ʘ Nevirapine ʘ ʘ ʘ ʘ ʘ Odefsey (ʘ) ʘ ʘ ʘ ʘ Raltegravir ʘ ʘ ʘ ʘ ʘ Rezolsta (ʘ) ʘ ʘ ʘ ʘ Rilpivirine (ʘ) ʘ ʘ ʘ ʘ Stribild (ʘ) ʘ ʘ ʘ ʘ Symtuza (ʘ) ʘ ʘ ʘ ʘ Tenofovir ʘ ʘ ʘ ʘ ʘ Triumeq ʘ ʘ ʘ ʘ ʘ Zidovudine ʘ ʘ ʘ ʘ ʘ Zidovudine/ lamivudine ʘ ʘ ʘ (ʘ) ʘ

www.westsussexsexualhealth.nhs.uk Department: Sexual Health Issue date: May 2020 Review date: May 2022 Author: Dr William Spice Version: V2